Electrically evoked compound action potentials are different depending on the site of cochlear stimulation.
Identifieur interne : 003F55 ( Ncbi/Merge ); précédent : 003F54; suivant : 003F56Electrically evoked compound action potentials are different depending on the site of cochlear stimulation.
Auteurs : Paul Van De Heyning [Belgique] ; Santiago L. Arauz [Argentine] ; Marcus Atlas [Australie] ; Wolf-Dieter Baumgartner [Autriche] ; Marco Caversaccio [Suisse] ; Ronel Chester-Browne [Australie] ; Patricia Estienne [Argentine] ; Javier Gavilan [Espagne] ; Benoit Godey [France] ; Wolfgang Gstöttner [Autriche] ; Demin Han [République populaire de Chine] ; Rudolph Hagen [Allemagne] ; Martin Kompis [Suisse] ; Vlad Kuzovkov [Russie] ; Luis Lassaletta [Espagne] ; Franc Lefevre [France] ; Yongxin Li [République populaire de Chine] ; Joachim Müller [Allemagne] ; Lorne Parnes [Canada] ; Andrea Kleine Punte [Belgique] ; Christopher Raine [Royaume-Uni] ; Gunesh Rajan [Australie] ; Adriana Rivas [Colombie] ; José Antonio Rivas [Colombie] ; Nicola Royle [Royaume-Uni] ; Georg Sprinzl [Autriche] ; Kurt Stephan [Autriche] ; Adam Walkowiak [Pologne] ; Yuri Yanov [Russie] ; Kim Zimmermann [Canada] ; Patrick Zorowka [Autriche] ; Henryk Skarzynski [Pologne]Source :
- Cochlear implants international [ 1754-7628 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Cochlée (physiopathologie), Femelle, Humains, Implantation cochléaire (), Implants cochléaires, Mâle, Potentiels d'action, Potentiels évoqués auditifs, Résultat thérapeutique, Stimulation électrique (), Surdité neurosensorielle (), Surdité neurosensorielle (physiopathologie), Études prospectives.
- MESH :
English descriptors
- KwdEn :
- Action Potentials, Adult, Cochlea (physiopathology), Cochlear Implantation (methods), Cochlear Implants, Electric Stimulation (methods), Evoked Potentials, Auditory, Female, Hearing Loss, Sensorineural (physiopathology), Hearing Loss, Sensorineural (surgery), Humans, Male, Prospective Studies, Treatment Outcome.
- MESH :
- methods : Cochlear Implantation, Electric Stimulation.
- physiopathology : Cochlea, Hearing Loss, Sensorineural.
- surgery : Hearing Loss, Sensorineural.
- Action Potentials, Adult, Cochlear Implants, Evoked Potentials, Auditory, Female, Humans, Male, Prospective Studies, Treatment Outcome.
Abstract
One of the many parameters that can affect cochlear implant (CI) users' performance is the site of presentation of electrical stimulation, from the CI, to the auditory nerve. Evoked compound action potential (ECAP) measurements are commonly used to verify nerve function by stimulating one electrode contact in the cochlea and recording the resulting action potentials on the other contacts of the electrode array. The present study aimed to determine if the ECAP amplitude differs between the apical, middle, and basal region of the cochlea, if double peak potentials were more likely in the apex than the basal region of the cochlea, and if there were differences in the ECAP threshold and recovery function across the cochlea. ECAP measurements were performed in the apical, middle, and basal region of the cochlea at fixed sites of stimulation with varying recording electrodes. One hundred and forty one adult subjects with severe to profound sensorineural hearing loss fitted with a Standard or FLEX(SOFT) electrode were included in this study. ECAP responses were captured using MAESTRO System Software (MED-EL). The ECAP amplitude, threshold, and slope were determined using amplitude growth sequences. The 50% recovery rate was assessed using independent single sequences that have two stimulation pulses (a masker and a probe pulse) separated by a variable inter-pulse interval. For all recordings, ECAP peaks were annotated semi-automatically. ECAP amplitudes were greater upon stimulation of the apical region compared to the basal region of the cochlea. ECAP slopes were steeper in the apical region compared to the basal region of the cochlea and ECAP thresholds were lower in the middle region compared to the basal region of the cochlea. The incidence of double peaks was greater upon stimulation of the apical region compared to the basal region of the cochlea. This data indicates that the site and intensity of cochlear stimulation affect ECAP properties.
DOI: 10.1080/14670100.2016.1240427
PubMed: 27900916
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Javier" sort="Gavilan, Javier" uniqKey="Gavilan J" first="Javier" last="Gavilan">Javier Gavilan</name><affiliation wicri:level="1"><nlm:affiliation>g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation></author><author><name sortKey="Godey, Benoit" sort="Godey, Benoit" uniqKey="Godey B" first="Benoit" last="Godey">Benoit Godey</name><affiliation wicri:level="1"><nlm:affiliation>h Centre Hospitalier Universitaire de Rennes , Rennes , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>h Centre Hospitalier Universitaire de Rennes , Rennes </wicri:regionArea><wicri:noRegion>Rennes </wicri:noRegion><wicri:noRegion>Rennes </wicri:noRegion></affiliation></author><author><name sortKey="Gstottner, Wolfgang" sort="Gstottner, Wolfgang" uniqKey="Gstottner W" first="Wolfgang" last="Gstöttner">Wolfgang Gstöttner</name><affiliation wicri:level="1"><nlm:affiliation>e Medizinische Universität Wien, Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten , Vienna , Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>e Medizinische Universität Wien, Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten , Vienna </wicri:regionArea><wicri:noRegion>Vienna </wicri:noRegion></affiliation></author><author><name sortKey="Han, Demin" sort="Han, Demin" uniqKey="Han D" first="Demin" last="Han">Demin Han</name><affiliation wicri:level="1"><nlm:affiliation>i Capital Medical University, Beijing Tongren Hospital , Beijing , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>i Capital Medical University, Beijing Tongren Hospital , Beijing </wicri:regionArea><wicri:noRegion>Beijing </wicri:noRegion></affiliation></author><author><name sortKey="Hagen, Rudolph" sort="Hagen, Rudolph" uniqKey="Hagen R" first="Rudolph" last="Hagen">Rudolph Hagen</name><affiliation wicri:level="1"><nlm:affiliation>j Klinik und Poliklinik für Hals-, Nasen und Ohren- Krankheiten , Universität Würzburg , Würzburg , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>j Klinik und Poliklinik für Hals-, Nasen und Ohren- Krankheiten , Universität Würzburg , Würzburg </wicri:regionArea><wicri:noRegion>Würzburg </wicri:noRegion><wicri:noRegion>Würzburg </wicri:noRegion><wicri:noRegion>Würzburg </wicri:noRegion></affiliation></author><author><name sortKey="Kompis, Martin" sort="Kompis, Martin" uniqKey="Kompis M" first="Martin" last="Kompis">Martin Kompis</name><affiliation wicri:level="1"><nlm:affiliation>f Universitätsklinik für HNO, Kopf- und Halschirurgie, Inselspital Bern , Bern , Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>f Universitätsklinik für HNO, Kopf- und Halschirurgie, Inselspital Bern , Bern </wicri:regionArea><wicri:noRegion>Bern </wicri:noRegion></affiliation></author><author><name sortKey="Kuzovkov, Vlad" sort="Kuzovkov, Vlad" uniqKey="Kuzovkov V" first="Vlad" last="Kuzovkov">Vlad Kuzovkov</name><affiliation wicri:level="1"><nlm:affiliation>k St. Petersburg ENT and Speech Research Institute , St. Petersburg , Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>k St. Petersburg ENT and Speech Research Institute , St. Petersburg </wicri:regionArea><wicri:noRegion>St. Petersburg </wicri:noRegion></affiliation></author><author><name sortKey="Lassaletta, Luis" sort="Lassaletta, Luis" uniqKey="Lassaletta L" first="Luis" last="Lassaletta">Luis Lassaletta</name><affiliation wicri:level="1"><nlm:affiliation>g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation></author><author><name sortKey="Lefevre, Franc" sort="Lefevre, Franc" uniqKey="Lefevre F" first="Franc" last="Lefevre">Franc Lefevre</name><affiliation wicri:level="1"><nlm:affiliation>h Centre Hospitalier Universitaire de Rennes , Rennes , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>h Centre Hospitalier Universitaire de Rennes , Rennes </wicri:regionArea><wicri:noRegion>Rennes </wicri:noRegion><wicri:noRegion>Rennes </wicri:noRegion></affiliation></author><author><name sortKey="Li, Yongxin" sort="Li, Yongxin" uniqKey="Li Y" first="Yongxin" last="Li">Yongxin Li</name><affiliation wicri:level="1"><nlm:affiliation>i Capital Medical University, Beijing Tongren Hospital , Beijing , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>i Capital Medical University, Beijing Tongren Hospital , Beijing </wicri:regionArea><wicri:noRegion>Beijing </wicri:noRegion></affiliation></author><author><name sortKey="Muller, Joachim" sort="Muller, Joachim" uniqKey="Muller J" first="Joachim" last="Müller">Joachim Müller</name><affiliation wicri:level="1"><nlm:affiliation>l Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde , Klinikum der Universität München , München , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>l Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde , Klinikum der Universität München , München </wicri:regionArea><wicri:noRegion>München </wicri:noRegion><wicri:noRegion>München </wicri:noRegion><wicri:noRegion>München </wicri:noRegion></affiliation></author><author><name sortKey="Parnes, Lorne" sort="Parnes, Lorne" uniqKey="Parnes L" first="Lorne" last="Parnes">Lorne Parnes</name><affiliation wicri:level="1"><nlm:affiliation>m London Health Sciences Centre , London , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>m London Health Sciences Centre , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="Kleine Punte, Andrea" sort="Kleine Punte, Andrea" uniqKey="Kleine Punte A" first="Andrea" last="Kleine Punte">Andrea Kleine Punte</name><affiliation wicri:level="1"><nlm:affiliation>a Antwerp University Hospital , Antwerp , Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>a Antwerp University Hospital , Antwerp </wicri:regionArea><wicri:noRegion>Antwerp </wicri:noRegion></affiliation></author><author><name sortKey="Raine, Christopher" sort="Raine, Christopher" uniqKey="Raine C" first="Christopher" last="Raine">Christopher Raine</name><affiliation wicri:level="1"><nlm:affiliation>n Bradford Royal Infirmary , Bradford , United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>n Bradford Royal Infirmary , Bradford </wicri:regionArea><wicri:noRegion>Bradford </wicri:noRegion></affiliation></author><author><name sortKey="Rajan, Gunesh" sort="Rajan, Gunesh" uniqKey="Rajan G" first="Gunesh" last="Rajan">Gunesh Rajan</name><affiliation wicri:level="1"><nlm:affiliation>o Otolaryngology, Head & Neck Surgery Unit, School of Surgery , University of Western Australia, Fremantle Hospital , Fremantle , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>o Otolaryngology, Head & Neck Surgery Unit, School of Surgery , University of Western Australia, Fremantle Hospital , Fremantle </wicri:regionArea><wicri:noRegion>Fremantle </wicri:noRegion></affiliation></author><author><name sortKey="Rivas, Adriana" sort="Rivas, Adriana" uniqKey="Rivas A" first="Adriana" last="Rivas">Adriana Rivas</name><affiliation wicri:level="1"><nlm:affiliation>p Clinica Rivas, Centro Medico Otologico , Bogota , Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>p Clinica Rivas, Centro Medico Otologico , Bogota </wicri:regionArea><wicri:noRegion>Bogota </wicri:noRegion></affiliation></author><author><name sortKey="Rivas, Jose Antonio" sort="Rivas, Jose Antonio" uniqKey="Rivas J" first="José Antonio" last="Rivas">José Antonio Rivas</name><affiliation wicri:level="1"><nlm:affiliation>p Clinica Rivas, Centro Medico Otologico , Bogota , Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>p Clinica Rivas, Centro Medico Otologico , Bogota </wicri:regionArea><wicri:noRegion>Bogota </wicri:noRegion></affiliation></author><author><name sortKey="Royle, Nicola" sort="Royle, Nicola" uniqKey="Royle N" first="Nicola" last="Royle">Nicola Royle</name><affiliation wicri:level="1"><nlm:affiliation>n Bradford Royal Infirmary , Bradford , United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>n Bradford Royal Infirmary , Bradford </wicri:regionArea><wicri:noRegion>Bradford </wicri:noRegion></affiliation></author><author><name sortKey="Sprinzl, Georg" sort="Sprinzl, Georg" uniqKey="Sprinzl G" first="Georg" last="Sprinzl">Georg Sprinzl</name><affiliation wicri:level="1"><nlm:affiliation>q Universitätsklinik für Hals- Nasen- Ohrenheilkunde Innsbruck , Innsbruck , Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>q Universitätsklinik für Hals- Nasen- Ohrenheilkunde Innsbruck , Innsbruck </wicri:regionArea><wicri:noRegion>Innsbruck </wicri:noRegion></affiliation></author><author><name sortKey="Stephan, Kurt" sort="Stephan, Kurt" uniqKey="Stephan K" first="Kurt" last="Stephan">Kurt Stephan</name><affiliation wicri:level="1"><nlm:affiliation>r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck , Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck </wicri:regionArea><wicri:noRegion>Innsbruck </wicri:noRegion></affiliation></author><author><name sortKey="Walkowiak, Adam" sort="Walkowiak, Adam" uniqKey="Walkowiak A" first="Adam" last="Walkowiak">Adam Walkowiak</name><affiliation wicri:level="1"><nlm:affiliation>s Institute of Physiology and Pathology of Hearing , Warsaw , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>s Institute of Physiology and Pathology of Hearing , Warsaw </wicri:regionArea><wicri:noRegion>Warsaw </wicri:noRegion></affiliation></author><author><name sortKey="Yanov, Yuri" sort="Yanov, Yuri" uniqKey="Yanov Y" first="Yuri" last="Yanov">Yuri Yanov</name><affiliation wicri:level="1"><nlm:affiliation>k St. Petersburg ENT and Speech Research Institute , St. Petersburg , Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>k St. Petersburg ENT and Speech Research Institute , St. Petersburg </wicri:regionArea><wicri:noRegion>St. Petersburg </wicri:noRegion></affiliation></author><author><name sortKey="Zimmermann, Kim" sort="Zimmermann, Kim" uniqKey="Zimmermann K" first="Kim" last="Zimmermann">Kim Zimmermann</name><affiliation wicri:level="1"><nlm:affiliation>m London Health Sciences Centre , London , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>m London Health Sciences Centre , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="Zorowka, Patrick" sort="Zorowka, Patrick" uniqKey="Zorowka P" first="Patrick" last="Zorowka">Patrick Zorowka</name><affiliation wicri:level="1"><nlm:affiliation>r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck , Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck </wicri:regionArea><wicri:noRegion>Innsbruck </wicri:noRegion></affiliation></author><author><name sortKey="Skarzynski, Henryk" sort="Skarzynski, Henryk" uniqKey="Skarzynski H" first="Henryk" last="Skarzynski">Henryk Skarzynski</name><affiliation wicri:level="1"><nlm:affiliation>s Institute of Physiology and Pathology of Hearing , Warsaw , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>s Institute of Physiology and Pathology of Hearing , Warsaw </wicri:regionArea><wicri:noRegion>Warsaw </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27900916</idno><idno type="pmid">27900916</idno><idno type="doi">10.1080/14670100.2016.1240427</idno><idno type="wicri:Area/PubMed/Corpus">001634</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001634</idno><idno type="wicri:Area/PubMed/Curation">001612</idno><idno type="wicri:explorRef" 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last="Arauz">Santiago L. Arauz</name><affiliation wicri:level="1"><nlm:affiliation>b Instituto de ORL , Buenos Aires , Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>b Instituto de ORL , Buenos Aires </wicri:regionArea><wicri:noRegion>Buenos Aires </wicri:noRegion></affiliation></author><author><name sortKey="Atlas, Marcus" sort="Atlas, Marcus" uniqKey="Atlas M" first="Marcus" last="Atlas">Marcus Atlas</name><affiliation wicri:level="1"><nlm:affiliation>c Ear Science Centre, School of Surgery , The University of Western Australia , Nedlands , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>c Ear Science Centre, School of Surgery , The University of Western Australia , Nedlands </wicri:regionArea><wicri:noRegion>Nedlands </wicri:noRegion></affiliation></author><author><name sortKey="Baumgartner, Wolf Dieter" sort="Baumgartner, Wolf Dieter" uniqKey="Baumgartner W" first="Wolf-Dieter" last="Baumgartner">Wolf-Dieter Baumgartner</name><affiliation wicri:level="1"><nlm:affiliation>e Medizinische Universität Wien, Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten , Vienna , Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>e Medizinische Universität Wien, Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten , Vienna </wicri:regionArea><wicri:noRegion>Vienna </wicri:noRegion></affiliation></author><author><name sortKey="Caversaccio, Marco" sort="Caversaccio, Marco" uniqKey="Caversaccio M" first="Marco" last="Caversaccio">Marco Caversaccio</name><affiliation wicri:level="1"><nlm:affiliation>f Universitätsklinik für HNO, Kopf- und Halschirurgie, Inselspital Bern , Bern , Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>f Universitätsklinik für HNO, Kopf- und Halschirurgie, Inselspital Bern , Bern </wicri:regionArea><wicri:noRegion>Bern </wicri:noRegion></affiliation></author><author><name sortKey="Chester Browne, Ronel" sort="Chester Browne, Ronel" uniqKey="Chester Browne R" first="Ronel" last="Chester-Browne">Ronel Chester-Browne</name><affiliation wicri:level="1"><nlm:affiliation>c Ear Science Centre, School of Surgery , The University of Western Australia , Nedlands , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>c Ear Science Centre, School of Surgery , The University of Western Australia , Nedlands </wicri:regionArea><wicri:noRegion>Nedlands </wicri:noRegion></affiliation></author><author><name sortKey="Estienne, Patricia" sort="Estienne, Patricia" uniqKey="Estienne P" first="Patricia" last="Estienne">Patricia Estienne</name><affiliation wicri:level="1"><nlm:affiliation>b Instituto de ORL , Buenos Aires , Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>b Instituto de ORL , Buenos Aires </wicri:regionArea><wicri:noRegion>Buenos Aires </wicri:noRegion></affiliation></author><author><name sortKey="Gavilan, Javier" sort="Gavilan, Javier" uniqKey="Gavilan J" first="Javier" last="Gavilan">Javier Gavilan</name><affiliation wicri:level="1"><nlm:affiliation>g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation></author><author><name sortKey="Godey, Benoit" sort="Godey, Benoit" uniqKey="Godey B" first="Benoit" last="Godey">Benoit Godey</name><affiliation wicri:level="1"><nlm:affiliation>h Centre Hospitalier Universitaire de Rennes , Rennes , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>h Centre Hospitalier Universitaire de Rennes , Rennes </wicri:regionArea><wicri:noRegion>Rennes </wicri:noRegion><wicri:noRegion>Rennes </wicri:noRegion></affiliation></author><author><name sortKey="Gstottner, Wolfgang" sort="Gstottner, Wolfgang" uniqKey="Gstottner W" first="Wolfgang" last="Gstöttner">Wolfgang Gstöttner</name><affiliation wicri:level="1"><nlm:affiliation>e Medizinische Universität Wien, Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten , Vienna , Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>e Medizinische Universität Wien, Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten , Vienna </wicri:regionArea><wicri:noRegion>Vienna </wicri:noRegion></affiliation></author><author><name sortKey="Han, Demin" sort="Han, Demin" uniqKey="Han D" first="Demin" last="Han">Demin Han</name><affiliation wicri:level="1"><nlm:affiliation>i Capital Medical University, Beijing Tongren Hospital , Beijing , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>i Capital Medical University, Beijing Tongren Hospital , Beijing </wicri:regionArea><wicri:noRegion>Beijing </wicri:noRegion></affiliation></author><author><name sortKey="Hagen, Rudolph" sort="Hagen, Rudolph" uniqKey="Hagen R" first="Rudolph" last="Hagen">Rudolph Hagen</name><affiliation wicri:level="1"><nlm:affiliation>j Klinik und Poliklinik für Hals-, Nasen und Ohren- Krankheiten , Universität Würzburg , Würzburg , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>j Klinik und Poliklinik für Hals-, Nasen und Ohren- Krankheiten , Universität Würzburg , Würzburg </wicri:regionArea><wicri:noRegion>Würzburg </wicri:noRegion><wicri:noRegion>Würzburg </wicri:noRegion><wicri:noRegion>Würzburg </wicri:noRegion></affiliation></author><author><name sortKey="Kompis, Martin" sort="Kompis, Martin" uniqKey="Kompis M" first="Martin" last="Kompis">Martin Kompis</name><affiliation wicri:level="1"><nlm:affiliation>f Universitätsklinik für HNO, Kopf- und Halschirurgie, Inselspital Bern , Bern , Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>f Universitätsklinik für HNO, Kopf- und Halschirurgie, Inselspital Bern , Bern </wicri:regionArea><wicri:noRegion>Bern </wicri:noRegion></affiliation></author><author><name sortKey="Kuzovkov, Vlad" sort="Kuzovkov, Vlad" uniqKey="Kuzovkov V" first="Vlad" last="Kuzovkov">Vlad Kuzovkov</name><affiliation wicri:level="1"><nlm:affiliation>k St. Petersburg ENT and Speech Research Institute , St. Petersburg , Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>k St. Petersburg ENT and Speech Research Institute , St. Petersburg </wicri:regionArea><wicri:noRegion>St. Petersburg </wicri:noRegion></affiliation></author><author><name sortKey="Lassaletta, Luis" sort="Lassaletta, Luis" uniqKey="Lassaletta L" first="Luis" last="Lassaletta">Luis Lassaletta</name><affiliation wicri:level="1"><nlm:affiliation>g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation></author><author><name sortKey="Lefevre, Franc" sort="Lefevre, Franc" uniqKey="Lefevre F" first="Franc" last="Lefevre">Franc Lefevre</name><affiliation wicri:level="1"><nlm:affiliation>h Centre Hospitalier Universitaire de Rennes , Rennes , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>h Centre Hospitalier Universitaire de Rennes , Rennes </wicri:regionArea><wicri:noRegion>Rennes </wicri:noRegion><wicri:noRegion>Rennes </wicri:noRegion></affiliation></author><author><name sortKey="Li, Yongxin" sort="Li, Yongxin" uniqKey="Li Y" first="Yongxin" last="Li">Yongxin Li</name><affiliation wicri:level="1"><nlm:affiliation>i Capital Medical University, Beijing Tongren Hospital , Beijing , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>i Capital Medical University, Beijing Tongren Hospital , Beijing </wicri:regionArea><wicri:noRegion>Beijing </wicri:noRegion></affiliation></author><author><name sortKey="Muller, Joachim" sort="Muller, Joachim" uniqKey="Muller J" first="Joachim" last="Müller">Joachim Müller</name><affiliation wicri:level="1"><nlm:affiliation>l Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde , Klinikum der Universität München , München , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>l Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde , Klinikum der Universität München , München </wicri:regionArea><wicri:noRegion>München </wicri:noRegion><wicri:noRegion>München </wicri:noRegion><wicri:noRegion>München </wicri:noRegion></affiliation></author><author><name sortKey="Parnes, Lorne" sort="Parnes, Lorne" uniqKey="Parnes L" first="Lorne" last="Parnes">Lorne Parnes</name><affiliation wicri:level="1"><nlm:affiliation>m London Health Sciences Centre , London , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>m London Health Sciences Centre , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="Kleine Punte, Andrea" sort="Kleine Punte, Andrea" uniqKey="Kleine Punte A" first="Andrea" last="Kleine Punte">Andrea Kleine Punte</name><affiliation wicri:level="1"><nlm:affiliation>a Antwerp University Hospital , Antwerp , Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>a Antwerp University Hospital , Antwerp </wicri:regionArea><wicri:noRegion>Antwerp </wicri:noRegion></affiliation></author><author><name sortKey="Raine, Christopher" sort="Raine, Christopher" uniqKey="Raine C" first="Christopher" last="Raine">Christopher Raine</name><affiliation wicri:level="1"><nlm:affiliation>n Bradford Royal Infirmary , Bradford , United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>n Bradford Royal Infirmary , Bradford </wicri:regionArea><wicri:noRegion>Bradford </wicri:noRegion></affiliation></author><author><name sortKey="Rajan, Gunesh" sort="Rajan, Gunesh" uniqKey="Rajan G" first="Gunesh" last="Rajan">Gunesh Rajan</name><affiliation wicri:level="1"><nlm:affiliation>o Otolaryngology, Head & Neck Surgery Unit, School of Surgery , University of Western Australia, Fremantle Hospital , Fremantle , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>o Otolaryngology, Head & Neck Surgery Unit, School of Surgery , University of Western Australia, Fremantle Hospital , Fremantle </wicri:regionArea><wicri:noRegion>Fremantle </wicri:noRegion></affiliation></author><author><name sortKey="Rivas, Adriana" sort="Rivas, Adriana" uniqKey="Rivas A" first="Adriana" last="Rivas">Adriana Rivas</name><affiliation wicri:level="1"><nlm:affiliation>p Clinica Rivas, Centro Medico Otologico , Bogota , Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>p Clinica Rivas, Centro Medico Otologico , Bogota </wicri:regionArea><wicri:noRegion>Bogota </wicri:noRegion></affiliation></author><author><name sortKey="Rivas, Jose Antonio" sort="Rivas, Jose Antonio" uniqKey="Rivas J" first="José Antonio" last="Rivas">José Antonio Rivas</name><affiliation wicri:level="1"><nlm:affiliation>p Clinica Rivas, Centro Medico Otologico , Bogota , Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>p Clinica Rivas, Centro Medico Otologico , Bogota </wicri:regionArea><wicri:noRegion>Bogota </wicri:noRegion></affiliation></author><author><name sortKey="Royle, Nicola" sort="Royle, Nicola" uniqKey="Royle N" first="Nicola" last="Royle">Nicola Royle</name><affiliation wicri:level="1"><nlm:affiliation>n Bradford Royal Infirmary , Bradford , United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>n Bradford Royal Infirmary , Bradford </wicri:regionArea><wicri:noRegion>Bradford </wicri:noRegion></affiliation></author><author><name sortKey="Sprinzl, Georg" sort="Sprinzl, Georg" uniqKey="Sprinzl G" first="Georg" last="Sprinzl">Georg Sprinzl</name><affiliation wicri:level="1"><nlm:affiliation>q Universitätsklinik für Hals- Nasen- Ohrenheilkunde Innsbruck , Innsbruck , Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>q Universitätsklinik für Hals- Nasen- Ohrenheilkunde Innsbruck , Innsbruck </wicri:regionArea><wicri:noRegion>Innsbruck </wicri:noRegion></affiliation></author><author><name sortKey="Stephan, Kurt" sort="Stephan, Kurt" uniqKey="Stephan K" first="Kurt" last="Stephan">Kurt Stephan</name><affiliation wicri:level="1"><nlm:affiliation>r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck , Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck </wicri:regionArea><wicri:noRegion>Innsbruck </wicri:noRegion></affiliation></author><author><name sortKey="Walkowiak, Adam" sort="Walkowiak, Adam" uniqKey="Walkowiak A" first="Adam" last="Walkowiak">Adam Walkowiak</name><affiliation wicri:level="1"><nlm:affiliation>s Institute of Physiology and Pathology of Hearing , Warsaw , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>s Institute of Physiology and Pathology of Hearing , Warsaw </wicri:regionArea><wicri:noRegion>Warsaw </wicri:noRegion></affiliation></author><author><name sortKey="Yanov, Yuri" sort="Yanov, Yuri" uniqKey="Yanov Y" first="Yuri" last="Yanov">Yuri Yanov</name><affiliation wicri:level="1"><nlm:affiliation>k St. Petersburg ENT and Speech Research Institute , St. Petersburg , Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>k St. Petersburg ENT and Speech Research Institute , St. Petersburg </wicri:regionArea><wicri:noRegion>St. Petersburg </wicri:noRegion></affiliation></author><author><name sortKey="Zimmermann, Kim" sort="Zimmermann, Kim" uniqKey="Zimmermann K" first="Kim" last="Zimmermann">Kim Zimmermann</name><affiliation wicri:level="1"><nlm:affiliation>m London Health Sciences Centre , London , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>m London Health Sciences Centre , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="Zorowka, Patrick" sort="Zorowka, Patrick" uniqKey="Zorowka P" first="Patrick" last="Zorowka">Patrick Zorowka</name><affiliation wicri:level="1"><nlm:affiliation>r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck , Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck </wicri:regionArea><wicri:noRegion>Innsbruck </wicri:noRegion></affiliation></author><author><name sortKey="Skarzynski, Henryk" sort="Skarzynski, Henryk" uniqKey="Skarzynski H" first="Henryk" last="Skarzynski">Henryk Skarzynski</name><affiliation wicri:level="1"><nlm:affiliation>s Institute of Physiology and Pathology of Hearing , Warsaw , Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>s Institute of Physiology and Pathology of Hearing , Warsaw </wicri:regionArea><wicri:noRegion>Warsaw </wicri:noRegion></affiliation></author></analytic><series><title level="j">Cochlear implants international</title><idno type="eISSN">1754-7628</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials</term><term>Adult</term><term>Cochlea (physiopathology)</term><term>Cochlear Implantation (methods)</term><term>Cochlear Implants</term><term>Electric Stimulation (methods)</term><term>Evoked Potentials, Auditory</term><term>Female</term><term>Hearing Loss, Sensorineural (physiopathology)</term><term>Hearing Loss, Sensorineural (surgery)</term><term>Humans</term><term>Male</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Cochlée (physiopathologie)</term><term>Femelle</term><term>Humains</term><term>Implantation cochléaire ()</term><term>Implants cochléaires</term><term>Mâle</term><term>Potentiels d'action</term><term>Potentiels évoqués auditifs</term><term>Résultat thérapeutique</term><term>Stimulation électrique ()</term><term>Surdité neurosensorielle ()</term><term>Surdité neurosensorielle (physiopathologie)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cochlear Implantation</term><term>Electric Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Cochlée</term><term>Surdité neurosensorielle</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cochlea</term><term>Hearing Loss, Sensorineural</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Hearing Loss, Sensorineural</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Action Potentials</term><term>Adult</term><term>Cochlear Implants</term><term>Evoked Potentials, Auditory</term><term>Female</term><term>Humans</term><term>Male</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Humains</term><term>Implantation cochléaire</term><term>Implants cochléaires</term><term>Mâle</term><term>Potentiels d'action</term><term>Potentiels évoqués auditifs</term><term>Résultat thérapeutique</term><term>Stimulation électrique</term><term>Surdité neurosensorielle</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One of the many parameters that can affect cochlear implant (CI) users' performance is the site of presentation of electrical stimulation, from the CI, to the auditory nerve. Evoked compound action potential (ECAP) measurements are commonly used to verify nerve function by stimulating one electrode contact in the cochlea and recording the resulting action potentials on the other contacts of the electrode array. The present study aimed to determine if the ECAP amplitude differs between the apical, middle, and basal region of the cochlea, if double peak potentials were more likely in the apex than the basal region of the cochlea, and if there were differences in the ECAP threshold and recovery function across the cochlea. ECAP measurements were performed in the apical, middle, and basal region of the cochlea at fixed sites of stimulation with varying recording electrodes. One hundred and forty one adult subjects with severe to profound sensorineural hearing loss fitted with a Standard or FLEX(SOFT) electrode were included in this study. ECAP responses were captured using MAESTRO System Software (MED-EL). The ECAP amplitude, threshold, and slope were determined using amplitude growth sequences. The 50% recovery rate was assessed using independent single sequences that have two stimulation pulses (a masker and a probe pulse) separated by a variable inter-pulse interval. For all recordings, ECAP peaks were annotated semi-automatically. ECAP amplitudes were greater upon stimulation of the apical region compared to the basal region of the cochlea. ECAP slopes were steeper in the apical region compared to the basal region of the cochlea and ECAP thresholds were lower in the middle region compared to the basal region of the cochlea. The incidence of double peaks was greater upon stimulation of the apical region compared to the basal region of the cochlea. This data indicates that the site and intensity of cochlear stimulation affect ECAP properties.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27900916</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>30</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>05</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1754-7628</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>11</Month></PubDate></JournalIssue><Title>Cochlear implants international</Title><ISOAbbreviation>Cochlear Implants Int</ISOAbbreviation></Journal><ArticleTitle>Electrically evoked compound action potentials are different depending on the site of cochlear stimulation.</ArticleTitle><Pagination><MedlinePgn>251-262</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/14670100.2016.1240427</ELocationID><Abstract><AbstractText>One of the many parameters that can affect cochlear implant (CI) users' performance is the site of presentation of electrical stimulation, from the CI, to the auditory nerve. Evoked compound action potential (ECAP) measurements are commonly used to verify nerve function by stimulating one electrode contact in the cochlea and recording the resulting action potentials on the other contacts of the electrode array. The present study aimed to determine if the ECAP amplitude differs between the apical, middle, and basal region of the cochlea, if double peak potentials were more likely in the apex than the basal region of the cochlea, and if there were differences in the ECAP threshold and recovery function across the cochlea. ECAP measurements were performed in the apical, middle, and basal region of the cochlea at fixed sites of stimulation with varying recording electrodes. One hundred and forty one adult subjects with severe to profound sensorineural hearing loss fitted with a Standard or FLEX(SOFT) electrode were included in this study. ECAP responses were captured using MAESTRO System Software (MED-EL). The ECAP amplitude, threshold, and slope were determined using amplitude growth sequences. The 50% recovery rate was assessed using independent single sequences that have two stimulation pulses (a masker and a probe pulse) separated by a variable inter-pulse interval. For all recordings, ECAP peaks were annotated semi-automatically. ECAP amplitudes were greater upon stimulation of the apical region compared to the basal region of the cochlea. ECAP slopes were steeper in the apical region compared to the basal region of the cochlea and ECAP thresholds were lower in the middle region compared to the basal region of the cochlea. The incidence of double peaks was greater upon stimulation of the apical region compared to the basal region of the cochlea. This data indicates that the site and intensity of cochlear stimulation affect ECAP properties.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van de Heyning</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>a Antwerp University Hospital , Antwerp , Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arauz</LastName><ForeName>Santiago L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>b Instituto de ORL , Buenos Aires , Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Atlas</LastName><ForeName>Marcus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>c Ear Science Centre, School of Surgery , The University of Western Australia , Nedlands , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>d Ear Science Institute Australia Implant Centre , Subiaco , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baumgartner</LastName><ForeName>Wolf-Dieter</ForeName><Initials>WD</Initials><AffiliationInfo><Affiliation>e Medizinische Universität Wien, Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten , Vienna , Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caversaccio</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>f Universitätsklinik für HNO, Kopf- und Halschirurgie, Inselspital Bern , Bern , Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chester-Browne</LastName><ForeName>Ronel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>c Ear Science Centre, School of Surgery , The University of Western Australia , Nedlands , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>d Ear Science Institute Australia Implant Centre , Subiaco , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Estienne</LastName><ForeName>Patricia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>b Instituto de ORL , Buenos Aires , Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gavilan</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Godey</LastName><ForeName>Benoit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>h Centre Hospitalier Universitaire de Rennes , Rennes , France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gstöttner</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>e Medizinische Universität Wien, Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten , Vienna , Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Demin</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>i Capital Medical University, Beijing Tongren Hospital , Beijing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hagen</LastName><ForeName>Rudolph</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>j Klinik und Poliklinik für Hals-, Nasen und Ohren- Krankheiten , Universität Würzburg , Würzburg , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kompis</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>f Universitätsklinik für HNO, Kopf- und Halschirurgie, Inselspital Bern , Bern , Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuzovkov</LastName><ForeName>Vlad</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>k St. Petersburg ENT and Speech Research Institute , St. Petersburg , Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lassaletta</LastName><ForeName>Luis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lefevre</LastName><ForeName>Franc</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>h Centre Hospitalier Universitaire de Rennes , Rennes , France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yongxin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>i Capital Medical University, Beijing Tongren Hospital , Beijing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Joachim</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>l Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde , Klinikum der Universität München , München , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parnes</LastName><ForeName>Lorne</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>m London Health Sciences Centre , London , Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kleine Punte</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>a Antwerp University Hospital , Antwerp , Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raine</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>n Bradford Royal Infirmary , Bradford , United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajan</LastName><ForeName>Gunesh</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>o Otolaryngology, Head & Neck Surgery Unit, School of Surgery , University of Western Australia, Fremantle Hospital , Fremantle , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rivas</LastName><ForeName>Adriana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>p Clinica Rivas, Centro Medico Otologico , Bogota , Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rivas</LastName><ForeName>José Antonio</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>p Clinica Rivas, Centro Medico Otologico , Bogota , Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Royle</LastName><ForeName>Nicola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>n Bradford Royal Infirmary , Bradford , United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sprinzl</LastName><ForeName>Georg</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>q Universitätsklinik für Hals- Nasen- Ohrenheilkunde Innsbruck , Innsbruck , Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stephan</LastName><ForeName>Kurt</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck , Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walkowiak</LastName><ForeName>Adam</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>s Institute of Physiology and Pathology of Hearing , Warsaw , Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>t World Hearing Center , Nadarzyn , Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>u Institute of Sensory Organs , Nadarzyn , Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yanov</LastName><ForeName>Yuri</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>k St. Petersburg ENT and Speech Research Institute , St. Petersburg , Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zimmermann</LastName><ForeName>Kim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>m London Health Sciences Centre , London , Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zorowka</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck , Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Skarzynski</LastName><ForeName>Henryk</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>s Institute of Physiology and Pathology of Hearing , Warsaw , Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>t World Hearing Center , Nadarzyn , Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>u Institute of Sensory Organs , Nadarzyn , Poland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cochlear Implants Int</MedlineTA><NlmUniqueID>101121166</NlmUniqueID><ISSNLinking>1467-0100</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000200" MajorTopicYN="Y">Action Potentials</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003051" MajorTopicYN="N">Cochlea</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019929" MajorTopicYN="N">Cochlear Implantation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003054" MajorTopicYN="Y">Cochlear Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004558" MajorTopicYN="N">Electric Stimulation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005072" MajorTopicYN="Y">Evoked Potentials, Auditory</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006319" MajorTopicYN="N">Hearing Loss, Sensorineural</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">ART</Keyword><Keyword MajorTopicYN="Y">Amplitude</Keyword><Keyword MajorTopicYN="Y">Apical</Keyword><Keyword MajorTopicYN="Y">Basal</Keyword><Keyword MajorTopicYN="Y">Cochlea</Keyword><Keyword MajorTopicYN="Y">Cochlear implant</Keyword><Keyword MajorTopicYN="Y">Double peak</Keyword><Keyword MajorTopicYN="Y">ECAP</Keyword><Keyword MajorTopicYN="Y">Electrode</Keyword><Keyword MajorTopicYN="Y">Middle</Keyword><Keyword MajorTopicYN="Y">Recovery sequence</Keyword><Keyword MajorTopicYN="Y">Threshold</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>12</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27900916</ArticleId><ArticleId IdType="doi">10.1080/14670100.2016.1240427</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>Colombie</li><li>Espagne</li><li>France</li><li>Pologne</li><li>Royaume-Uni</li><li>Russie</li><li>République populaire de Chine</li><li>Suisse</li></country></list><tree><country name="Belgique"><noRegion><name sortKey="Van De Heyning, Paul" sort="Van De Heyning, Paul" 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