AustralieFrV1, Ncbi, Merge, bibRecord, 003161

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials.

Identifieur interne : 003161 ( Ncbi/Merge ); précédent : 003160; suivant : 003162

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials.

Auteurs : Mayank Goyal [Canada] ; Bijoy K. Menon [Canada] ; Wim H. Van Zwam [Pays-Bas] ; Diederik W J. Dippel [Pays-Bas] ; Peter J. Mitchell [Australie] ; Andrew M. Demchuk [Canada] ; Antoni Dávalos [Espagne] ; Charles B L M. Majoie [Pays-Bas] ; Aad Van Der Lugt [Pays-Bas] ; Maria A. De Miquel [Espagne] ; Geoffrey A. Donnan [Australie] ; Yvo B W E M. Roos [Pays-Bas] ; Alain Bonafe [France] ; Reza Jahan [États-Unis] ; Hans-Christoph Diener [Allemagne] ; Lucie A. Van Den Berg [Pays-Bas] ; Elad I. Levy [États-Unis] ; Olvert A. Berkhemer [Pays-Bas] ; Vitor M. Pereira [Canada] ; Jeremy Rempel [Canada] ; M Nica Millán [Espagne] ; Stephen M. Davis [Australie] ; Daniel Roy [Canada] ; John Thornton [Irlande (pays)] ; Luis San Román [Espagne] ; Marc Rib [Espagne] ; Debbie Beumer [Pays-Bas] ; Bruce Stouch [États-Unis] ; Scott Brown [États-Unis] ; Bruce C V. Campbell [Australie] ; Robert J. Van Oostenbrugge [Pays-Bas] ; Jeffrey L. Saver [États-Unis] ; Michael D. Hill [Canada] ; Tudor G. Jovin [États-Unis]

Source :

Lancet (London, England) [ 1474-547X ] ; 2016.

RBID : pubmed:26898852

Descripteurs français

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Brain Ischemia (complications), Brain Ischemia (therapy), Endovascular Procedures (methods), Female, Fibrinolytic Agents (therapeutic use), Humans, Intracranial Hemorrhages (chemically induced), Male, Middle Aged, Odds Ratio, Randomized Controlled Trials as Topic, Stroke (etiology), Stroke (therapy), Thrombectomy (methods), Tissue Plasminogen Activator (therapeutic use), Treatment Outcome.
MESH :
- chemical , therapeutic use : Fibrinolytic Agents, Tissue Plasminogen Activator.
- chemically induced : Intracranial Hemorrhages.
- complications : Brain Ischemia.
- etiology : Stroke.
- methods : Endovascular Procedures, Thrombectomy.
- therapy : Brain Ischemia, Stroke.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Odds Ratio, Randomized Controlled Trials as Topic, Treatment Outcome.

Abstract

In 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. In this meta-analysis we, the trial investigators, aimed to pool individual patient data from these trials to address remaining questions about whether the therapy is efficacious across the diverse populations included.

DOI: 10.1016/S0140-6736(16)00163-X
PubMed: 26898852

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Le document en format XML

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<author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name>
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<author><name sortKey="Roos, Yvo B W E M" sort="Roos, Yvo B W E M" uniqKey="Roos Y" first="Yvo B W E M" last="Roos">Yvo B W E M. Roos</name>
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<author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name>
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<author><name sortKey="Millan, M Nica" sort="Millan, M Nica" uniqKey="Millan M" first="M Nica" last="Millán">M Nica Millán</name>
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<author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. Davis</name>
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<author><name sortKey="Roy, Daniel" sort="Roy, Daniel" uniqKey="Roy D" first="Daniel" last="Roy">Daniel Roy</name>
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<author><name sortKey="Thornton, John" sort="Thornton, John" uniqKey="Thornton J" first="John" last="Thornton">John Thornton</name>
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<author><name sortKey="Roman, Luis San" sort="Roman, Luis San" uniqKey="Roman L" first="Luis San" last="Román">Luis San Román</name>
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<author><name sortKey="Rib, Marc" sort="Rib, Marc" uniqKey="Rib M" first="Marc" last="Rib">Marc Rib</name>
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<wicri:regionArea>Hospital Vall d'Hebron, Barcelona</wicri:regionArea>
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<author><name sortKey="Beumer, Debbie" sort="Beumer, Debbie" uniqKey="Beumer D" first="Debbie" last="Beumer">Debbie Beumer</name>
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<author><name sortKey="Stouch, Bruce" sort="Stouch, Bruce" uniqKey="Stouch B" first="Bruce" last="Stouch">Bruce Stouch</name>
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<placeName><region type="state">Pennsylvanie</region>
</placeName>
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<author><name sortKey="Brown, Scott" sort="Brown, Scott" uniqKey="Brown S" first="Scott" last="Brown">Scott Brown</name>
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<placeName><region type="state">Minnesota</region>
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<author><name sortKey="Campbell, Bruce C V" sort="Campbell, Bruce C V" uniqKey="Campbell B" first="Bruce C V" last="Campbell">Bruce C V. Campbell</name>
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<wicri:regionArea>Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
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<author><name sortKey="Van Oostenbrugge, Robert J" sort="Van Oostenbrugge, Robert J" uniqKey="Van Oostenbrugge R" first="Robert J" last="Van Oostenbrugge">Robert J. Van Oostenbrugge</name>
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<author><name sortKey="Saver, Jeffrey L" sort="Saver, Jeffrey L" uniqKey="Saver J" first="Jeffrey L" last="Saver">Jeffrey L. Saver</name>
<affiliation wicri:level="2"><nlm:affiliation>David Geffen School of Medicine, University of Los Angeles, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>David Geffen School of Medicine, University of Los Angeles, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D" last="Hill">Michael D. Hill</name>
<affiliation wicri:level="4"><nlm:affiliation>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
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<author><name sortKey="Jovin, Tudor G" sort="Jovin, Tudor G" uniqKey="Jovin T" first="Tudor G" last="Jovin">Tudor G. Jovin</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Medical Center Stroke Institute, Presbyterian University Hospital, Pittsburgh, PA, USA. Electronic address: jovintg@upmc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Medical Center Stroke Institute, Presbyterian University Hospital, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials.</title>
<author><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name>
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<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Menon, Bijoy K" sort="Menon, Bijoy K" uniqKey="Menon B" first="Bijoy K" last="Menon">Bijoy K. Menon</name>
<affiliation wicri:level="4"><nlm:affiliation>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Zwam, Wim H" sort="Van Zwam, Wim H" uniqKey="Van Zwam W" first="Wim H" last="Van Zwam">Wim H. Van Zwam</name>
<affiliation wicri:level="1"><nlm:affiliation>Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dippel, Diederik W J" sort="Dippel, Diederik W J" uniqKey="Dippel D" first="Diederik W J" last="Dippel">Diederik W J. Dippel</name>
<affiliation wicri:level="3"><nlm:affiliation>Erasmus MC University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitchell, Peter J" sort="Mitchell, Peter J" uniqKey="Mitchell P" first="Peter J" last="Mitchell">Peter J. Mitchell</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M" last="Demchuk">Andrew M. Demchuk</name>
<affiliation wicri:level="4"><nlm:affiliation>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davalos, Antoni" sort="Davalos, Antoni" uniqKey="Davalos A" first="Antoni" last="Dávalos">Antoni Dávalos</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital Germans Trias y Pujol, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Germans Trias y Pujol, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Majoie, Charles B L M" sort="Majoie, Charles B L M" uniqKey="Majoie C" first="Charles B L M" last="Majoie">Charles B L M. Majoie</name>
<affiliation wicri:level="3"><nlm:affiliation>Academic Medical Center, Amsterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name>
<affiliation wicri:level="3"><nlm:affiliation>Erasmus MC University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Miquel, Maria A" sort="De Miquel, Maria A" uniqKey="De Miquel M" first="Maria A" last="De Miquel">Maria A. De Miquel</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital de Bellvitge, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital de Bellvitge, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A" last="Donnan">Geoffrey A. Donnan</name>
<affiliation wicri:level="4"><nlm:affiliation>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roos, Yvo B W E M" sort="Roos, Yvo B W E M" uniqKey="Roos Y" first="Yvo B W E M" last="Roos">Yvo B W E M. Roos</name>
<affiliation wicri:level="3"><nlm:affiliation>Academic Medical Center, Amsterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonafe, Alain" sort="Bonafe, Alain" uniqKey="Bonafe A" first="Alain" last="Bonafe">Alain Bonafe</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital Guy de Chaulliac, Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hospital Guy de Chaulliac, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jahan, Reza" sort="Jahan, Reza" uniqKey="Jahan R" first="Reza" last="Jahan">Reza Jahan</name>
<affiliation wicri:level="2"><nlm:affiliation>UCLA Medical Center, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UCLA Medical Center, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital Essen, Essen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Den Berg, Lucie A" sort="Van Den Berg, Lucie A" uniqKey="Van Den Berg L" first="Lucie A" last="Van Den Berg">Lucie A. Van Den Berg</name>
<affiliation wicri:level="3"><nlm:affiliation>Academic Medical Center, Amsterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Levy, Elad I" sort="Levy, Elad I" uniqKey="Levy E" first="Elad I" last="Levy">Elad I. Levy</name>
<affiliation wicri:level="2"><nlm:affiliation>State University of New York, Buffalo, Buffalo, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>State University of New York, Buffalo, Buffalo, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berkhemer, Olvert A" sort="Berkhemer, Olvert A" uniqKey="Berkhemer O" first="Olvert A" last="Berkhemer">Olvert A. Berkhemer</name>
<affiliation wicri:level="3"><nlm:affiliation>Academic Medical Center, Amsterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pereira, Vitor M" sort="Pereira, Vitor M" uniqKey="Pereira V" first="Vitor M" last="Pereira">Vitor M. Pereira</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rempel, Jeremy" sort="Rempel, Jeremy" uniqKey="Rempel J" first="Jeremy" last="Rempel">Jeremy Rempel</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Edmonton, Edmonton, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Edmonton, Edmonton, AB</wicri:regionArea>
<wicri:noRegion>AB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Millan, M Nica" sort="Millan, M Nica" uniqKey="Millan M" first="M Nica" last="Millán">M Nica Millán</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital Germans Trials y Pujol, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Germans Trials y Pujol, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. Davis</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roy, Daniel" sort="Roy, Daniel" uniqKey="Roy D" first="Daniel" last="Roy">Daniel Roy</name>
<affiliation wicri:level="1"><nlm:affiliation>CHUM Notre-Dame Hospital, Montreal, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>CHUM Notre-Dame Hospital, Montreal, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thornton, John" sort="Thornton, John" uniqKey="Thornton J" first="John" last="Thornton">John Thornton</name>
<affiliation wicri:level="1"><nlm:affiliation>Beaumont Hospital, Dublin, Ireland.</nlm:affiliation>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Beaumont Hospital, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roman, Luis San" sort="Roman, Luis San" uniqKey="Roman L" first="Luis San" last="Román">Luis San Román</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital Clinic, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Clinic, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rib, Marc" sort="Rib, Marc" uniqKey="Rib M" first="Marc" last="Rib">Marc Rib</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital Vall d'Hebron, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Vall d'Hebron, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beumer, Debbie" sort="Beumer, Debbie" uniqKey="Beumer D" first="Debbie" last="Beumer">Debbie Beumer</name>
<affiliation wicri:level="1"><nlm:affiliation>Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stouch, Bruce" sort="Stouch, Bruce" uniqKey="Stouch B" first="Bruce" last="Stouch">Bruce Stouch</name>
<affiliation wicri:level="2"><nlm:affiliation>Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Philadelphia College of Osteopathic Medicine, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brown, Scott" sort="Brown, Scott" uniqKey="Brown S" first="Scott" last="Brown">Scott Brown</name>
<affiliation wicri:level="2"><nlm:affiliation>Altair Biostatistics, St Louis Park, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Altair Biostatistics, St Louis Park, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campbell, Bruce C V" sort="Campbell, Bruce C V" uniqKey="Campbell B" first="Bruce C V" last="Campbell">Bruce C V. Campbell</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Oostenbrugge, Robert J" sort="Van Oostenbrugge, Robert J" uniqKey="Van Oostenbrugge R" first="Robert J" last="Van Oostenbrugge">Robert J. Van Oostenbrugge</name>
<affiliation wicri:level="1"><nlm:affiliation>Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saver, Jeffrey L" sort="Saver, Jeffrey L" uniqKey="Saver J" first="Jeffrey L" last="Saver">Jeffrey L. Saver</name>
<affiliation wicri:level="2"><nlm:affiliation>David Geffen School of Medicine, University of Los Angeles, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>David Geffen School of Medicine, University of Los Angeles, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D" last="Hill">Michael D. Hill</name>
<affiliation wicri:level="4"><nlm:affiliation>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jovin, Tudor G" sort="Jovin, Tudor G" uniqKey="Jovin T" first="Tudor G" last="Jovin">Tudor G. Jovin</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Medical Center Stroke Institute, Presbyterian University Hospital, Pittsburgh, PA, USA. Electronic address: jovintg@upmc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Medical Center Stroke Institute, Presbyterian University Hospital, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Lancet (London, England)</title>
<idno type="eISSN">1474-547X</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Brain Ischemia (complications)</term>
<term>Brain Ischemia (therapy)</term>
<term>Endovascular Procedures (methods)</term>
<term>Female</term>
<term>Fibrinolytic Agents (therapeutic use)</term>
<term>Humans</term>
<term>Intracranial Hemorrhages (chemically induced)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Stroke (etiology)</term>
<term>Stroke (therapy)</term>
<term>Thrombectomy (methods)</term>
<term>Tissue Plasminogen Activator (therapeutic use)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral ()</term>
<term>Accident vasculaire cérébral (étiologie)</term>
<term>Activateur tissulaire du plasminogène (usage thérapeutique)</term>
<term>Adulte d'âge moyen</term>
<term>Encéphalopathie ischémique ()</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Femelle</term>
<term>Fibrinolytiques (usage thérapeutique)</term>
<term>Humains</term>
<term>Hémorragies intracrâniennes ()</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Procédures endovasculaires ()</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Thrombectomie ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Fibrinolytic Agents</term>
<term>Tissue Plasminogen Activator</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Intracranial Hemorrhages</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Brain Ischemia</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Stroke</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Endovascular Procedures</term>
<term>Thrombectomy</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Brain Ischemia</term>
<term>Stroke</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Activateur tissulaire du plasminogène</term>
<term>Fibrinolytiques</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Accident vasculaire cérébral</term>
<term>Adulte d'âge moyen</term>
<term>Encéphalopathie ischémique</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémorragies intracrâniennes</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Procédures endovasculaires</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Thrombectomie</term>
</keywords>
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<front><div type="abstract" xml:lang="en">In 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. In this meta-analysis we, the trial investigators, aimed to pool individual patient data from these trials to address remaining questions about whether the therapy is efficacious across the diverse populations included.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26898852</PMID>
<DateCreated><Year>2016</Year>
<Month>04</Month>
<Day>27</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>05</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>09</Month>
<Day>12</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-547X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>387</Volume>
<Issue>10029</Issue>
<PubDate><Year>2016</Year>
<Month>Apr</Month>
<Day>23</Day>
</PubDate>
</JournalIssue>
<Title>Lancet (London, England)</Title>
<ISOAbbreviation>Lancet</ISOAbbreviation>
</Journal>
<ArticleTitle>Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials.</ArticleTitle>
<Pagination><MedlinePgn>1723-31</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/S0140-6736(16)00163-X</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0140-6736(16)00163-X</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. In this meta-analysis we, the trial investigators, aimed to pool individual patient data from these trials to address remaining questions about whether the therapy is efficacious across the diverse populations included.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We formed the HERMES collaboration to pool patient-level data from five trials (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND IA) done between December, 2010, and December, 2014. In these trials, patients with acute ischaemic stroke caused by occlusion of the proximal anterior artery circulation were randomly assigned to receive either endovascular thrombectomy within 12 h of symptom onset or standard care (control), with a primary outcome of reduced disability on the modified Rankin Scale (mRS) at 90 days. By direct access to the study databases, we extracted individual patient data that we used to assess the primary outcome of reduced disability on mRS at 90 days in the pooled population and examine heterogeneity of this treatment effect across prespecified subgroups. To account for between-trial variance we used mixed-effects modelling with random effects for parameters of interest. We then used mixed-effects ordinal logistic regression models to calculate common odds ratios (cOR) for the primary outcome in the whole population (shift analysis) and in subgroups after adjustment for age, sex, baseline stroke severity (National Institutes of Health Stroke Scale score), site of occlusion (internal carotid artery vs M1 segment of middle cerebral artery vs M2 segment of middle cerebral artery), intravenous alteplase (yes vs no), baseline Alberta Stroke Program Early CT score, and time from stroke onset to randomisation.</AbstractText>
<AbstractText Label="FINDINGS" NlmCategory="RESULTS">We analysed individual data for 1287 patients (634 assigned to endovascular thrombectomy, 653 assigned to control). Endovascular thrombectomy led to significantly reduced disability at 90 days compared with control (adjusted cOR 2.49, 95% CI 1.76-3.53; p<0.0001). The number needed to treat with endovascular thrombectomy to reduce disability by at least one level on mRS for one patient was 2.6. Subgroup analysis of the primary endpoint showed no heterogeneity of treatment effect across prespecified subgroups for reduced disability (pinteraction=0.43). Effect sizes favouring endovascular thrombectomy over control were present in several strata of special interest, including in patients aged 80 years or older (cOR 3.68, 95% CI 1.95-6.92), those randomised more than 300 min after symptom onset (1.76, 1.05-2.97), and those not eligible for intravenous alteplase (2.43, 1.30-4.55). Mortality at 90 days and risk of parenchymal haematoma and symptomatic intracranial haemorrhage did not differ between populations.</AbstractText>
<AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Endovascular thrombectomy is of benefit to most patients with acute ischaemic stroke caused by occlusion of the proximal anterior circulation, irrespective of patient characteristics or geographical location. These findings will have global implications on structuring systems of care to provide timely treatment to patients with acute ischaemic stroke due to large vessel occlusion.</AbstractText>
<AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Medtronic.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Goyal</LastName>
<ForeName>Mayank</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Menon</LastName>
<ForeName>Bijoy K</ForeName>
<Initials>BK</Initials>
<AffiliationInfo><Affiliation>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Zwam</LastName>
<ForeName>Wim H</ForeName>
<Initials>WH</Initials>
<AffiliationInfo><Affiliation>Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dippel</LastName>
<ForeName>Diederik W J</ForeName>
<Initials>DW</Initials>
<AffiliationInfo><Affiliation>Erasmus MC University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mitchell</LastName>
<ForeName>Peter J</ForeName>
<Initials>PJ</Initials>
<AffiliationInfo><Affiliation>Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Demchuk</LastName>
<ForeName>Andrew M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dávalos</LastName>
<ForeName>Antoni</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Hospital Germans Trias y Pujol, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Majoie</LastName>
<ForeName>Charles B L M</ForeName>
<Initials>CB</Initials>
<AffiliationInfo><Affiliation>Academic Medical Center, Amsterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van der Lugt</LastName>
<ForeName>Aad</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Erasmus MC University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Miquel</LastName>
<ForeName>Maria A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Hospital de Bellvitge, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Donnan</LastName>
<ForeName>Geoffrey A</ForeName>
<Initials>GA</Initials>
<AffiliationInfo><Affiliation>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roos</LastName>
<ForeName>Yvo B W E M</ForeName>
<Initials>YB</Initials>
<AffiliationInfo><Affiliation>Academic Medical Center, Amsterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bonafe</LastName>
<ForeName>Alain</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Hospital Guy de Chaulliac, Montpellier, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jahan</LastName>
<ForeName>Reza</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>UCLA Medical Center, Los Angeles, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Diener</LastName>
<ForeName>Hans-Christoph</ForeName>
<Initials>HC</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, University Hospital Essen, Essen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van den Berg</LastName>
<ForeName>Lucie A</ForeName>
<Initials>LA</Initials>
<AffiliationInfo><Affiliation>Academic Medical Center, Amsterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Levy</LastName>
<ForeName>Elad I</ForeName>
<Initials>EI</Initials>
<AffiliationInfo><Affiliation>State University of New York, Buffalo, Buffalo, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Berkhemer</LastName>
<ForeName>Olvert A</ForeName>
<Initials>OA</Initials>
<AffiliationInfo><Affiliation>Academic Medical Center, Amsterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pereira</LastName>
<ForeName>Vitor M</ForeName>
<Initials>VM</Initials>
<AffiliationInfo><Affiliation>University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rempel</LastName>
<ForeName>Jeremy</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>University of Edmonton, Edmonton, AB, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Millán</LastName>
<ForeName>Mònica</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Hospital Germans Trials y Pujol, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Davis</LastName>
<ForeName>Stephen M</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roy</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>CHUM Notre-Dame Hospital, Montreal, QC, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thornton</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Beaumont Hospital, Dublin, Ireland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Román</LastName>
<ForeName>Luis San</ForeName>
<Initials>LS</Initials>
<AffiliationInfo><Affiliation>Hospital Clinic, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ribó</LastName>
<ForeName>Marc</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Hospital Vall d'Hebron, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Beumer</LastName>
<ForeName>Debbie</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stouch</LastName>
<ForeName>Bruce</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brown</LastName>
<ForeName>Scott</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Altair Biostatistics, St Louis Park, MN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Campbell</LastName>
<ForeName>Bruce C V</ForeName>
<Initials>BC</Initials>
<AffiliationInfo><Affiliation>Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Oostenbrugge</LastName>
<ForeName>Robert J</ForeName>
<Initials>RJ</Initials>
<AffiliationInfo><Affiliation>Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saver</LastName>
<ForeName>Jeffrey L</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>David Geffen School of Medicine, University of Los Angeles, Los Angeles, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hill</LastName>
<ForeName>Michael D</ForeName>
<Initials>MD</Initials>
<AffiliationInfo><Affiliation>Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jovin</LastName>
<ForeName>Tudor G</ForeName>
<Initials>TG</Initials>
<AffiliationInfo><Affiliation>University of Pittsburgh Medical Center Stroke Institute, Presbyterian University Hospital, Pittsburgh, PA, USA. Electronic address: jovintg@upmc.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>HERMES collaborators</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D017418">Meta-Analysis</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>02</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Lancet</MedlineTA>
<NlmUniqueID>2985213R</NlmUniqueID>
<ISSNLinking>0140-6736</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005343">Fibrinolytic Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.21.68</RegistryNumber>
<NameOfSubstance UI="D010959">Tissue Plasminogen Activator</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Lancet. 2016 Apr 23;387(10029):1695-7</RefSource>
<PMID Version="1">26898854</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Lancet. 2016 Aug 20;388(10046):757-8</RefSource>
<PMID Version="1">27560271</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002545" MajorTopicYN="N">Brain Ischemia</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057510" MajorTopicYN="N">Endovascular Procedures</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005343" MajorTopicYN="N">Fibrinolytic Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020300" MajorTopicYN="N">Intracranial Hemorrhages</DescriptorName>
<QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017131" MajorTopicYN="N">Thrombectomy</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010959" MajorTopicYN="N">Tissue Plasminogen Activator</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>2</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>2</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>5</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26898852</ArticleId>
<ArticleId IdType="pii">S0140-6736(16)00163-X</ArticleId>
<ArticleId IdType="doi">10.1016/S0140-6736(16)00163-X</ArticleId>
</ArticleIdList>
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<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Irlande (pays)</li>
<li>Pays-Bas</li>
<li>États-Unis</li>
</country>
<region><li>Alberta</li>
<li>Californie</li>
<li>Catalogne</li>
<li>Hollande-Méridionale</li>
<li>Hollande-Septentrionale</li>
<li>Languedoc-Roussillon</li>
<li>Minnesota</li>
<li>Occitanie (région administrative)</li>
<li>Ontario</li>
<li>Pennsylvanie</li>
<li>Victoria (État)</li>
<li>État de New York</li>
</region>
<settlement><li>Amsterdam</li>
<li>Barcelone</li>
<li>Calgary</li>
<li>Melbourne</li>
<li>Montpellier</li>
<li>Rotterdam</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université de Calgary</li>
<li>Université de Melbourne</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Alberta"><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name>
</region>
<name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M" last="Demchuk">Andrew M. Demchuk</name>
<name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D" last="Hill">Michael D. Hill</name>
<name sortKey="Menon, Bijoy K" sort="Menon, Bijoy K" uniqKey="Menon B" first="Bijoy K" last="Menon">Bijoy K. Menon</name>
<name sortKey="Pereira, Vitor M" sort="Pereira, Vitor M" uniqKey="Pereira V" first="Vitor M" last="Pereira">Vitor M. Pereira</name>
<name sortKey="Rempel, Jeremy" sort="Rempel, Jeremy" uniqKey="Rempel J" first="Jeremy" last="Rempel">Jeremy Rempel</name>
<name sortKey="Roy, Daniel" sort="Roy, Daniel" uniqKey="Roy D" first="Daniel" last="Roy">Daniel Roy</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Van Zwam, Wim H" sort="Van Zwam, Wim H" uniqKey="Van Zwam W" first="Wim H" last="Van Zwam">Wim H. Van Zwam</name>
</noRegion>
<name sortKey="Berkhemer, Olvert A" sort="Berkhemer, Olvert A" uniqKey="Berkhemer O" first="Olvert A" last="Berkhemer">Olvert A. Berkhemer</name>
<name sortKey="Beumer, Debbie" sort="Beumer, Debbie" uniqKey="Beumer D" first="Debbie" last="Beumer">Debbie Beumer</name>
<name sortKey="Dippel, Diederik W J" sort="Dippel, Diederik W J" uniqKey="Dippel D" first="Diederik W J" last="Dippel">Diederik W J. Dippel</name>
<name sortKey="Majoie, Charles B L M" sort="Majoie, Charles B L M" uniqKey="Majoie C" first="Charles B L M" last="Majoie">Charles B L M. Majoie</name>
<name sortKey="Roos, Yvo B W E M" sort="Roos, Yvo B W E M" uniqKey="Roos Y" first="Yvo B W E M" last="Roos">Yvo B W E M. Roos</name>
<name sortKey="Van Den Berg, Lucie A" sort="Van Den Berg, Lucie A" uniqKey="Van Den Berg L" first="Lucie A" last="Van Den Berg">Lucie A. Van Den Berg</name>
<name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name>
<name sortKey="Van Oostenbrugge, Robert J" sort="Van Oostenbrugge, Robert J" uniqKey="Van Oostenbrugge R" first="Robert J" last="Van Oostenbrugge">Robert J. Van Oostenbrugge</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Mitchell, Peter J" sort="Mitchell, Peter J" uniqKey="Mitchell P" first="Peter J" last="Mitchell">Peter J. Mitchell</name>
</region>
<name sortKey="Campbell, Bruce C V" sort="Campbell, Bruce C V" uniqKey="Campbell B" first="Bruce C V" last="Campbell">Bruce C V. Campbell</name>
<name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. Davis</name>
<name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A" last="Donnan">Geoffrey A. Donnan</name>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Davalos, Antoni" sort="Davalos, Antoni" uniqKey="Davalos A" first="Antoni" last="Dávalos">Antoni Dávalos</name>
</region>
<name sortKey="De Miquel, Maria A" sort="De Miquel, Maria A" uniqKey="De Miquel M" first="Maria A" last="De Miquel">Maria A. De Miquel</name>
<name sortKey="Millan, M Nica" sort="Millan, M Nica" uniqKey="Millan M" first="M Nica" last="Millán">M Nica Millán</name>
<name sortKey="Rib, Marc" sort="Rib, Marc" uniqKey="Rib M" first="Marc" last="Rib">Marc Rib</name>
<name sortKey="Roman, Luis San" sort="Roman, Luis San" uniqKey="Roman L" first="Luis San" last="Román">Luis San Román</name>
</country>
<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Bonafe, Alain" sort="Bonafe, Alain" uniqKey="Bonafe A" first="Alain" last="Bonafe">Alain Bonafe</name>
</region>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Jahan, Reza" sort="Jahan, Reza" uniqKey="Jahan R" first="Reza" last="Jahan">Reza Jahan</name>
</region>
<name sortKey="Brown, Scott" sort="Brown, Scott" uniqKey="Brown S" first="Scott" last="Brown">Scott Brown</name>
<name sortKey="Jovin, Tudor G" sort="Jovin, Tudor G" uniqKey="Jovin T" first="Tudor G" last="Jovin">Tudor G. Jovin</name>
<name sortKey="Levy, Elad I" sort="Levy, Elad I" uniqKey="Levy E" first="Elad I" last="Levy">Elad I. Levy</name>
<name sortKey="Saver, Jeffrey L" sort="Saver, Jeffrey L" uniqKey="Saver J" first="Jeffrey L" last="Saver">Jeffrey L. Saver</name>
<name sortKey="Stouch, Bruce" sort="Stouch, Bruce" uniqKey="Stouch B" first="Bruce" last="Stouch">Bruce Stouch</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name>
</noRegion>
</country>
<country name="Irlande (pays)"><noRegion><name sortKey="Thornton, John" sort="Thornton, John" uniqKey="Thornton J" first="John" last="Thornton">John Thornton</name>
</noRegion>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials.

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials.

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