Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis.
Identifieur interne : 002B63 ( Ncbi/Merge ); précédent : 002B62; suivant : 002B64Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis.
Auteurs : Claire Roger [France] ; Bastian Nucci [France] ; Benjamin Louart [France] ; Arnaud Friggeri [France] ; Haroun Knani [France] ; Alexandre Evrard [France] ; Jean-Philippe Lavigne [France] ; Bernard Allaouchiche [France] ; Jean-Yves Lefrant [France] ; Jason A. Roberts [Australie] ; Laurent Muller [France]Source :
- The Journal of antimicrobial chemotherapy [ 1460-2091 ] ; 2016.
Descripteurs français
- KwdFr :
- Administration par voie intraveineuse, Adulte, Adulte d'âge moyen, Amikacine (administration et posologie), Amikacine (pharmacocinétique), Antibactériens (administration et posologie), Antibactériens (pharmacocinétique), Femelle, France, Gentamicine (administration et posologie), Gentamicine (pharmacocinétique), Humains, Jeune adulte, Maladie grave, Mâle, Sepsie (traitement médicamenteux), Sujet âgé, Sujet âgé de 80 ans ou plus, Sérum (), Tests de sensibilité microbienne.
- MESH :
- administration et posologie : Amikacine, Antibactériens, Gentamicine.
- pharmacocinétique : Amikacine, Antibactériens, Gentamicine.
- traitement médicamenteux : Sepsie.
- Administration par voie intraveineuse, Adulte, Adulte d'âge moyen, Femelle, France, Humains, Jeune adulte, Maladie grave, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Sérum, Tests de sensibilité microbienne.
English descriptors
- KwdEn :
- Administration, Intravenous, Adult, Aged, Aged, 80 and over, Amikacin (administration & dosage), Amikacin (pharmacokinetics), Anti-Bacterial Agents (administration & dosage), Anti-Bacterial Agents (pharmacokinetics), Critical Illness, Female, France, Gentamicins (administration & dosage), Gentamicins (pharmacokinetics), Humans, Male, Microbial Sensitivity Tests, Middle Aged, Sepsis (drug therapy), Serum (chemistry), Young Adult.
- MESH :
- chemical , administration & dosage : Amikacin, Anti-Bacterial Agents, Gentamicins.
- chemical , pharmacokinetics : Amikacin, Anti-Bacterial Agents, Gentamicins.
- chemistry : Serum.
- drug therapy : Sepsis.
- Administration, Intravenous, Adult, Aged, Aged, 80 and over, Critical Illness, Female, France, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Young Adult.
Abstract
Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU patients with severe sepsis.
DOI: 10.1093/jac/dkv291
PubMed: 26429564
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pubmed:26429564Le document en format XML
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Professeur Robert Debré, 30 029 Nîmes cedex 9, France EA 2992, Université de Montpellier, Faculté de Médecine Montpellier Nîmes, Chemin du Carreau de Lanes, 30 908 Nîmes cedex 02</wicri:regionArea><wicri:noRegion>30 908 Nîmes cedex 02</wicri:noRegion><wicri:noRegion>30 908 Nîmes cedex 02</wicri:noRegion></affiliation></author><author><name sortKey="Nucci, Bastian" sort="Nucci, Bastian" uniqKey="Nucci B" first="Bastian" last="Nucci">Bastian Nucci</name><affiliation wicri:level="1"><nlm:affiliation>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9</wicri:regionArea><wicri:noRegion>30 029 Nîmes cedex 9</wicri:noRegion><wicri:noRegion>30 029 Nîmes cedex 9</wicri:noRegion></affiliation></author><author><name sortKey="Louart, Benjamin" sort="Louart, Benjamin" uniqKey="Louart B" first="Benjamin" last="Louart">Benjamin Louart</name><affiliation wicri:level="1"><nlm:affiliation>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France EA 2992, Université de Montpellier, Faculté de Médecine Montpellier Nîmes, Chemin du Carreau de Lanes, 30 908 Nîmes cedex 02, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France EA 2992, Université de Montpellier, Faculté de Médecine Montpellier Nîmes, Chemin du Carreau de Lanes, 30 908 Nîmes cedex 02</wicri:regionArea><wicri:noRegion>30 908 Nîmes cedex 02</wicri:noRegion><wicri:noRegion>30 908 Nîmes cedex 02</wicri:noRegion></affiliation></author><author><name sortKey="Friggeri, Arnaud" sort="Friggeri, Arnaud" uniqKey="Friggeri A" first="Arnaud" last="Friggeri">Arnaud Friggeri</name><affiliation wicri:level="1"><nlm:affiliation>Service de Réanimation, Centre Hospitalier Lyon Sud, Pierre Bénite, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation, Centre Hospitalier Lyon Sud, Pierre Bénite</wicri:regionArea><wicri:noRegion>Pierre Bénite</wicri:noRegion><wicri:noRegion>Pierre Bénite</wicri:noRegion></affiliation></author><author><name sortKey="Knani, Haroun" sort="Knani, Haroun" uniqKey="Knani H" first="Haroun" last="Knani">Haroun Knani</name><affiliation wicri:level="1"><nlm:affiliation>Service de Pharmacie, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Pharmacie, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9</wicri:regionArea><wicri:noRegion>30 029 Nîmes cedex 9</wicri:noRegion><wicri:noRegion>30 029 Nîmes cedex 9</wicri:noRegion></affiliation></author><author><name sortKey="Evrard, Alexandre" sort="Evrard, Alexandre" uniqKey="Evrard A" first="Alexandre" last="Evrard">Alexandre Evrard</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Biochimie, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Biochimie, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9</wicri:regionArea><wicri:noRegion>30 029 Nîmes cedex 9</wicri:noRegion><wicri:noRegion>30 029 Nîmes cedex 9</wicri:noRegion></affiliation></author><author><name sortKey="Lavigne, Jean Philippe" sort="Lavigne, Jean Philippe" uniqKey="Lavigne J" first="Jean-Philippe" last="Lavigne">Jean-Philippe Lavigne</name><affiliation wicri:level="1"><nlm:affiliation>Service de Microbiologie, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France INSERM, U1047, Université de Montpellier, Chemin du Carreau de Lanes, 30 908 Nîmes Cedex 02, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Microbiologie, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France INSERM, U1047, Université de Montpellier, Chemin du Carreau de Lanes, 30 908 Nîmes Cedex 02</wicri:regionArea><wicri:noRegion>30 908 Nîmes Cedex 02</wicri:noRegion><wicri:noRegion>30 908 Nîmes Cedex 02</wicri:noRegion></affiliation></author><author><name sortKey="Allaouchiche, Bernard" sort="Allaouchiche, Bernard" uniqKey="Allaouchiche B" first="Bernard" last="Allaouchiche">Bernard Allaouchiche</name><affiliation wicri:level="1"><nlm:affiliation>Service de Réanimation, Centre Hospitalier Lyon Sud, Pierre Bénite, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation, Centre Hospitalier Lyon Sud, Pierre Bénite</wicri:regionArea><wicri:noRegion>Pierre Bénite</wicri:noRegion><wicri:noRegion>Pierre Bénite</wicri:noRegion></affiliation></author><author><name sortKey="Lefrant, Jean Yves" sort="Lefrant, Jean Yves" uniqKey="Lefrant J" first="Jean-Yves" last="Lefrant">Jean-Yves Lefrant</name><affiliation wicri:level="1"><nlm:affiliation>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France EA 2992, Université de Montpellier, Faculté de Médecine Montpellier Nîmes, Chemin du Carreau de Lanes, 30 908 Nîmes cedex 02, France jean-yves.lefrant@wanadoo.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France EA 2992, Université de Montpellier, Faculté de Médecine Montpellier Nîmes, Chemin du Carreau de Lanes, 30 908 Nîmes cedex 02</wicri:regionArea><wicri:noRegion>30 908 Nîmes cedex 02</wicri:noRegion><wicri:noRegion>30 908 Nîmes cedex 02</wicri:noRegion></affiliation></author><author><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. Roberts</name><affiliation wicri:level="1"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, The University of Queensland, Royal Brisbane and Women's Hospital, Herston, Brisbane 4029, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Royal Brisbane and Women's Hospital, Herston, Brisbane 4029</wicri:regionArea><wicri:noRegion>Brisbane 4029</wicri:noRegion></affiliation></author><author><name sortKey="Muller, Laurent" sort="Muller, Laurent" uniqKey="Muller L" first="Laurent" last="Muller">Laurent Muller</name><affiliation wicri:level="1"><nlm:affiliation>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France EA 2992, Université de Montpellier, Faculté de Médecine Montpellier Nîmes, Chemin du Carreau de Lanes, 30 908 Nîmes cedex 02, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France EA 2992, Université de Montpellier, Faculté de Médecine Montpellier Nîmes, Chemin du Carreau de Lanes, 30 908 Nîmes cedex 02</wicri:regionArea><wicri:noRegion>30 908 Nîmes cedex 02</wicri:noRegion><wicri:noRegion>30 908 Nîmes cedex 02</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of antimicrobial chemotherapy</title><idno type="eISSN">1460-2091</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intravenous</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Amikacin (administration & dosage)</term><term>Amikacin (pharmacokinetics)</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Anti-Bacterial Agents (pharmacokinetics)</term><term>Critical Illness</term><term>Female</term><term>France</term><term>Gentamicins (administration & dosage)</term><term>Gentamicins (pharmacokinetics)</term><term>Humans</term><term>Male</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term><term>Sepsis (drug therapy)</term><term>Serum (chemistry)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie intraveineuse</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Amikacine (administration et posologie)</term><term>Amikacine (pharmacocinétique)</term><term>Antibactériens (administration et posologie)</term><term>Antibactériens (pharmacocinétique)</term><term>Femelle</term><term>France</term><term>Gentamicine (administration et posologie)</term><term>Gentamicine (pharmacocinétique)</term><term>Humains</term><term>Jeune adulte</term><term>Maladie grave</term><term>Mâle</term><term>Sepsie (traitement médicamenteux)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Sérum ()</term><term>Tests de sensibilité microbienne</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Amikacin</term><term>Anti-Bacterial Agents</term><term>Gentamicins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Amikacin</term><term>Anti-Bacterial Agents</term><term>Gentamicins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Amikacine</term><term>Antibactériens</term><term>Gentamicine</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Serum</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Sepsis</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Amikacine</term><term>Antibactériens</term><term>Gentamicine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Sepsie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intravenous</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Critical Illness</term><term>Female</term><term>France</term><term>Humans</term><term>Male</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie intraveineuse</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>France</term><term>Humains</term><term>Jeune adulte</term><term>Maladie grave</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Sérum</term><term>Tests de sensibilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU patients with severe sepsis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26429564</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>17</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>05</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-2091</ISSN><JournalIssue CitedMedium="Internet"><Volume>71</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Jan</Month></PubDate></JournalIssue><Title>The Journal of antimicrobial chemotherapy</Title><ISOAbbreviation>J. Antimicrob. Chemother.</ISOAbbreviation></Journal><ArticleTitle>Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis.</ArticleTitle><Pagination><MedlinePgn>208-12</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/jac/dkv291</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU patients with severe sepsis.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Sixty-three ICU patients (Simplified Acute Physiology Score II = 43 ± 16) with severe sepsis and an indication for intravenous amikacin (n = 47) or gentamicin (n = 16) were included. The first (30 mg/kg amikacin; 8 mg/kg gentamicin) and subsequent doses and corresponding peak concentrations (30 min after the completion of an infusion) were recorded. French guideline target concentrations were ≥60 and ≥30 mg/L for amikacin and gentamicin, respectively. A target pharmacokinetic/pharmacodynamic ratio of 10 × MIC was also measured.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Pulmonary, abdominal and urinary tract infections were diagnosed in 56 patients. Infection was confirmed in 37 patients (59%). The targeted first-dose peak concentration was achieved in 37/63 patients (59%) [amikacin 36/47 (77%) and gentamicin 1/16 (6%)], and 59/63 patients (94%) achieved the pharmacokinetic/pharmacodynamic ratio using the MIC data that were available from 21 patients. However, the second dose of aminoglycoside was withheld because of high trough concentrations in nearly half of patients who did not have renal dysfunction.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In this study, 30 mg/kg amikacin and 8 mg/kg gentamicin led to target peak serum concentrations in 59% of patients.</AbstractText><CopyrightInformation>© The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Roger</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France EA 2992, Université de Montpellier, Faculté de Médecine Montpellier Nîmes, Chemin du Carreau de Lanes, 30 908 Nîmes cedex 02, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nucci</LastName><ForeName>Bastian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Louart</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France EA 2992, Université de Montpellier, Faculté de Médecine Montpellier Nîmes, Chemin du Carreau de Lanes, 30 908 Nîmes cedex 02, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Friggeri</LastName><ForeName>Arnaud</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Service de Réanimation, Centre Hospitalier Lyon Sud, Pierre Bénite, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Knani</LastName><ForeName>Haroun</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Service de Pharmacie, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evrard</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratoire de Biochimie, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lavigne</LastName><ForeName>Jean-Philippe</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Service de Microbiologie, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France INSERM, U1047, Université de Montpellier, Chemin du Carreau de Lanes, 30 908 Nîmes Cedex 02, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allaouchiche</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Service de Réanimation, Centre Hospitalier Lyon Sud, Pierre Bénite, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lefrant</LastName><ForeName>Jean-Yves</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France EA 2992, Université de Montpellier, Faculté de Médecine Montpellier Nîmes, Chemin du Carreau de Lanes, 30 908 Nîmes cedex 02, France jean-yves.lefrant@wanadoo.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roberts</LastName><ForeName>Jason A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Burns Trauma and Critical Care Research Centre, The University of Queensland, Royal Brisbane and Women's Hospital, Herston, Brisbane 4029, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muller</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France EA 2992, Université de Montpellier, Faculté de Médecine Montpellier Nîmes, Chemin du Carreau de Lanes, 30 908 Nîmes cedex 02, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>10</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Antimicrob Chemother</MedlineTA><NlmUniqueID>7513617</NlmUniqueID><ISSNLinking>0305-7453</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005839">Gentamicins</NameOfSubstance></Chemical><Chemical><RegistryNumber>84319SGC3C</RegistryNumber><NameOfSubstance UI="D000583">Amikacin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D061605" MajorTopicYN="N">Administration, Intravenous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000583" MajorTopicYN="N">Amikacin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N">France</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005839" MajorTopicYN="N">Gentamicins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018805" MajorTopicYN="N">Sepsis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044967" MajorTopicYN="N">Serum</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>04</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>08</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26429564</ArticleId><ArticleId IdType="pii">dkv291</ArticleId><ArticleId IdType="doi">10.1093/jac/dkv291</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Roger, Claire" sort="Roger, Claire" uniqKey="Roger C" first="Claire" last="Roger">Claire Roger</name></noRegion><name sortKey="Allaouchiche, Bernard" sort="Allaouchiche, Bernard" uniqKey="Allaouchiche B" first="Bernard" last="Allaouchiche">Bernard Allaouchiche</name><name sortKey="Evrard, Alexandre" sort="Evrard, Alexandre" uniqKey="Evrard A" first="Alexandre" last="Evrard">Alexandre Evrard</name><name sortKey="Friggeri, Arnaud" sort="Friggeri, Arnaud" uniqKey="Friggeri A" first="Arnaud" last="Friggeri">Arnaud Friggeri</name><name sortKey="Knani, Haroun" sort="Knani, Haroun" uniqKey="Knani H" first="Haroun" last="Knani">Haroun Knani</name><name sortKey="Lavigne, Jean Philippe" sort="Lavigne, Jean Philippe" uniqKey="Lavigne J" first="Jean-Philippe" last="Lavigne">Jean-Philippe Lavigne</name><name sortKey="Lefrant, Jean Yves" sort="Lefrant, Jean Yves" uniqKey="Lefrant J" first="Jean-Yves" last="Lefrant">Jean-Yves Lefrant</name><name sortKey="Louart, Benjamin" sort="Louart, Benjamin" uniqKey="Louart B" first="Benjamin" last="Louart">Benjamin Louart</name><name sortKey="Muller, Laurent" sort="Muller, Laurent" uniqKey="Muller L" first="Laurent" last="Muller">Laurent Muller</name><name sortKey="Nucci, Bastian" sort="Nucci, Bastian" uniqKey="Nucci B" first="Bastian" last="Nucci">Bastian Nucci</name></country><country name="Australie"><noRegion><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. 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