Mammary Stem Cells: Premise, Properties, and Perspectives.
Identifieur interne : 004790 ( Ncbi/Curation ); précédent : 004789; suivant : 004791Mammary Stem Cells: Premise, Properties, and Perspectives.
Auteurs : Bethan Lloyd-Lewis [France] ; Olivia B. Harris [Royaume-Uni] ; Christine J. Watson [Royaume-Uni] ; Felicity M. Davis [Australie]Source :
- Trends in cell biology [ 1879-3088 ] ; 2017.
Abstract
Adult mammary stem cells (MaSCs) drive postnatal organogenesis and remodeling in the mammary gland, and their longevity and potential have important implications for breast cancer. However, despite intense investigation the identity, location, and differentiation potential of MaSCs remain subject to deliberation. The application of genetic lineage-tracing models, combined with quantitative 3D imaging and biophysical methods, has provided new insights into the mammary epithelial hierarchy that challenge classical definitions of MaSC potency and behaviors. We review here recent advances - discussing fundamental unresolved properties of MaSC potency, dynamics, and plasticity - and point to evolving technologies that promise to shed new light on this intractable debate. Elucidation of the physiological mammary differentiation hierarchy is paramount to understanding the complex heterogeneous breast cancer landscape.
DOI: 10.1016/j.tcb.2017.04.001
PubMed: 28487183
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000836
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000833
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000833
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :004790
Links to Exploration step
pubmed:28487183Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mammary Stem Cells: Premise, Properties, and Perspectives.</title>
<author><name sortKey="Lloyd Lewis, Bethan" sort="Lloyd Lewis, Bethan" uniqKey="Lloyd Lewis B" first="Bethan" last="Lloyd-Lewis">Bethan Lloyd-Lewis</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Current address: Department of Genetics and Developmental Biology, Institut Curie, Paris, France. Electronic address: bethan.lloyd-lewis@curie.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Current address: Department of Genetics and Developmental Biology, Institut Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Cambridge</settlement>
</placeName>
<orgName type="university">Université de Cambridge</orgName>
</affiliation>
</author>
<author><name sortKey="Harris, Olivia B" sort="Harris, Olivia B" uniqKey="Harris O" first="Olivia B" last="Harris">Olivia B. Harris</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Watson, Christine J" sort="Watson, Christine J" uniqKey="Watson C" first="Christine J" last="Watson">Christine J. Watson</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davis, Felicity M" sort="Davis, Felicity M" uniqKey="Davis F" first="Felicity M" last="Davis">Felicity M. Davis</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, University of Queensland, Brisbane 4102, Australia; Mater Research Institute, University of Queensland, Brisbane 4102, Australia. Electronic address: f.davis@uq.edu.au.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Pharmacy, University of Queensland, Brisbane 4102, Australia; Mater Research Institute, University of Queensland, Brisbane 4102</wicri:regionArea>
<wicri:noRegion>Brisbane 4102</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28487183</idno>
<idno type="pmid">28487183</idno>
<idno type="doi">10.1016/j.tcb.2017.04.001</idno>
<idno type="wicri:Area/PubMed/Corpus">000836</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000836</idno>
<idno type="wicri:Area/PubMed/Curation">000833</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000833</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000833</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000833</idno>
<idno type="wicri:Area/Ncbi/Merge">004790</idno>
<idno type="wicri:Area/Ncbi/Curation">004790</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Mammary Stem Cells: Premise, Properties, and Perspectives.</title>
<author><name sortKey="Lloyd Lewis, Bethan" sort="Lloyd Lewis, Bethan" uniqKey="Lloyd Lewis B" first="Bethan" last="Lloyd-Lewis">Bethan Lloyd-Lewis</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Current address: Department of Genetics and Developmental Biology, Institut Curie, Paris, France. Electronic address: bethan.lloyd-lewis@curie.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Current address: Department of Genetics and Developmental Biology, Institut Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Cambridge</settlement>
</placeName>
<orgName type="university">Université de Cambridge</orgName>
</affiliation>
</author>
<author><name sortKey="Harris, Olivia B" sort="Harris, Olivia B" uniqKey="Harris O" first="Olivia B" last="Harris">Olivia B. Harris</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Watson, Christine J" sort="Watson, Christine J" uniqKey="Watson C" first="Christine J" last="Watson">Christine J. Watson</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davis, Felicity M" sort="Davis, Felicity M" uniqKey="Davis F" first="Felicity M" last="Davis">Felicity M. Davis</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, University of Queensland, Brisbane 4102, Australia; Mater Research Institute, University of Queensland, Brisbane 4102, Australia. Electronic address: f.davis@uq.edu.au.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Pharmacy, University of Queensland, Brisbane 4102, Australia; Mater Research Institute, University of Queensland, Brisbane 4102</wicri:regionArea>
<wicri:noRegion>Brisbane 4102</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Trends in cell biology</title>
<idno type="eISSN">1879-3088</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Adult mammary stem cells (MaSCs) drive postnatal organogenesis and remodeling in the mammary gland, and their longevity and potential have important implications for breast cancer. However, despite intense investigation the identity, location, and differentiation potential of MaSCs remain subject to deliberation. The application of genetic lineage-tracing models, combined with quantitative 3D imaging and biophysical methods, has provided new insights into the mammary epithelial hierarchy that challenge classical definitions of MaSC potency and behaviors. We review here recent advances - discussing fundamental unresolved properties of MaSC potency, dynamics, and plasticity - and point to evolving technologies that promise to shed new light on this intractable debate. Elucidation of the physiological mammary differentiation hierarchy is paramount to understanding the complex heterogeneous breast cancer landscape.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004790 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 004790 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:28487183 |texte= Mammary Stem Cells: Premise, Properties, and Perspectives. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:28487183" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |