Development of vaccines for Plasmodium vivax malaria.
Identifieur interne : 002B62 ( Ncbi/Curation ); précédent : 002B61; suivant : 002B63Development of vaccines for Plasmodium vivax malaria.
Auteurs : Ivo Mueller [Espagne] ; Ahmad Rushdi Shakri [Inde] ; Chetan E. Chitnis [France]Source :
- Vaccine [ 1873-2518 ] ; 2015.
Descripteurs français
- KwdFr :
- Afrique, Amérique du Sud, Humains, Iles du Pacifique, Paludisme à Plasmodium vivax (), Paludisme à Plasmodium vivax (immunologie), Paludisme à Plasmodium vivax (transmission), Plasmodium vivax (immunologie), Plasmodium vivax (physiologie), Recherche biomédicale, Vaccins contre le paludisme (immunologie), Étapes du cycle de vie (immunologie).
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Malaria Vaccines.
- geographic : Africa, Pacific Islands, South America.
- immunology : Life Cycle Stages, Malaria, Vivax, Plasmodium vivax.
- physiology : Plasmodium vivax.
- prevention & control : Malaria, Vivax.
- transmission : Malaria, Vivax.
- Biomedical Research, Humans.
Abstract
Plasmodium vivax continues to cause significant morbidity outside Africa with more than 50% of malaria cases in many parts of South and South-east Asia, Pacific islands, Central and South America being attributed to P. vivax infections. The unique biology of P. vivax, including its ability to form latent hypnozoites that emerge months to years later to cause blood stage infections, early appearance of gametocytes before clinical symptoms are apparent and a shorter development cycle in the vector makes elimination of P. vivax using standard control tools difficult. The availability of an effective vaccine that provides protection and prevents transmission would be a valuable tool in efforts to eliminate P. vivax. Here, we review the latest developments related to P. vivax malaria vaccines and discuss the challenges as well as directions toward the goal of developing highly efficacious vaccines against P. vivax malaria.
DOI: 10.1016/j.vaccine.2015.09.060
PubMed: 26428453
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Chitnis</name><affiliation wicri:level="3"><nlm:affiliation>International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India; Institut Pasteur, Paris, France. 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The unique biology of P. vivax, including its ability to form latent hypnozoites that emerge months to years later to cause blood stage infections, early appearance of gametocytes before clinical symptoms are apparent and a shorter development cycle in the vector makes elimination of P. vivax using standard control tools difficult. The availability of an effective vaccine that provides protection and prevents transmission would be a valuable tool in efforts to eliminate P. vivax. Here, we review the latest developments related to P. vivax malaria vaccines and discuss the challenges as well as directions toward the goal of developing highly efficacious vaccines against P. vivax malaria.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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