Recent progress in translational research on neurovascular and neurodegenerative disorders
Identifieur interne : 004130 ( Ncbi/Checkpoint ); précédent : 004129; suivant : 004131Recent progress in translational research on neurovascular and neurodegenerative disorders
Auteurs : Hans-Ulrich Demuth [Allemagne] ; Rick M. Dijkhuizen [Pays-Bas] ; Tracy D. Farr [Royaume-Uni] ; Mathias Gelderblom [Allemagne] ; Karen Horsburgh [Royaume-Uni] ; Costantino Iadecola [États-Unis] ; Damian D. Mcleod [Australie] ; Dominik Michalski [Allemagne] ; Tim H. Murphy [Canada] ; Josune Orbe [Espagne] ; Willem M. Otte [Pays-Bas] ; Gabor C. Petzold [Allemagne] ; Nikolaus Plesnila [Allemagne] ; Georg Reiser [Allemagne] ; Klaus G. Reymann [Allemagne] ; Maria A. Rueger [Allemagne] ; Dorothee Saur [Allemagne] ; Sean I. Savitz [États-Unis] ; Stephan Schilling [Allemagne] ; Neil J. Spratt [Australie] ; Renée J. Turner [Australie] ; Raghu Vemuganti [États-Unis] ; Denis Vivien [France] ; Manuel Yepes [États-Unis] ; Marietta Zille [États-Unis] ; Johannes Boltze [Allemagne]Source :
- Restorative Neurology and Neuroscience [ 0922-6028 ] ; ????.
Abstract
The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient’s outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms.
This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurode- and -regeneration to late stage translational or early stage clinical investigations.
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DOI: 10.3233/RNN-160690
PubMed: 28059802
PubMed Central: 5302043
Affiliations:
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Murphy</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Psychiatry,<institution>University of British Columbia</institution>, Vancouver,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Orbe, Josune" sort="Orbe, Josune" uniqKey="Orbe J" first="Josune" last="Orbe">Josune Orbe</name><affiliation wicri:level="1"><nlm:aff id="aff10">Atherothrombosis Laboratory, Centre for Applied Medical Research,<institution>University of Navarra</institution>, Pamplona,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Otte, Willem M" sort="Otte, Willem M" uniqKey="Otte W" first="Willem M." last="Otte">Willem M. Otte</name><affiliation wicri:level="1"><nlm:aff id="aff2">Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences,<institution>University Medical Center Utrecht</institution>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Pediatric Neurology, Brain Center Rudolf Magnus,<institution>University Medical Center Utrecht</institution>, Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Petzold, Gabor C" sort="Petzold, Gabor C" uniqKey="Petzold G" first="Gabor C." last="Petzold">Gabor C. Petzold</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>German Center for Neurodegenerative Diseases</institution>, Bonn,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Plesnila, Nikolaus" sort="Plesnila, Nikolaus" uniqKey="Plesnila N" first="Nikolaus" last="Plesnila">Nikolaus Plesnila</name><affiliation wicri:level="1"><nlm:aff id="aff13">Institute for Stroke and Dementia Research (ISD),<institution>University of Munich Medical Center</institution>; Munich Cluster of Systems Neurology (Synergy), LMU Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reiser, Georg" sort="Reiser, Georg" uniqKey="Reiser G" first="Georg" last="Reiser">Georg Reiser</name><affiliation wicri:level="1"><nlm:aff id="aff14">Institute for Neurobiochemistry,<institution>University of Magdeburg</institution>, Magdeburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reymann, Klaus G" sort="Reymann, Klaus G" uniqKey="Reymann K" first="Klaus G." last="Reymann">Klaus G. Reymann</name><affiliation wicri:level="1"><nlm:aff id="aff15">Neuropharmacology Lab,<institution>Leibniz Institute for Neurobiology</institution>, Magdeburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rueger, Maria A" sort="Rueger, Maria A" uniqKey="Rueger M" first="Maria A." last="Rueger">Maria A. Rueger</name><affiliation wicri:level="1"><nlm:aff id="aff16">Department of Neurology,<institution>University Hospital of Cologne</institution>, Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saur, Dorothee" sort="Saur, Dorothee" uniqKey="Saur D" first="Dorothee" last="Saur">Dorothee Saur</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Neurology,<institution>University of Leipzig</institution>, Leipzig,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Savitz, Sean I" sort="Savitz, Sean I" uniqKey="Savitz S" first="Sean I." last="Savitz">Sean I. Savitz</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Neurology,<institution>UTHealth Medical School</institution>, Houston, TX,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schilling, Stephan" sort="Schilling, Stephan" uniqKey="Schilling S" first="Stephan" last="Schilling">Stephan Schilling</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Drug Design and Target Validation,<institution>Fraunhofer Institute for Cell Therapy and Immunology (IZI-MWT)</institution>, Halle/Saale,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spratt, Neil J" sort="Spratt, Neil J" uniqKey="Spratt N" first="Neil J." last="Spratt">Neil J. Spratt</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>University of Newcastle</institution>, Hunter Medical Research Institute and Hunter New England Local Health District, Newcastle,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Turner, Renee J" sort="Turner, Renee J" uniqKey="Turner R" first="Renée J." last="Turner">Renée J. Turner</name><affiliation wicri:level="1"><nlm:aff id="aff18">Adelaide Medical School and Adelaide Centre for Neuroscience Research,<institution>The University of Adelaide</institution>, Adelaide,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vemuganti, Raghu" sort="Vemuganti, Raghu" uniqKey="Vemuganti R" first="Raghu" last="Vemuganti">Raghu Vemuganti</name><affiliation wicri:level="1"><nlm:aff id="aff19">Deptartment of Neurological Surgery,<institution>University of Wisconsin and William S. Middleton VA Hospital</institution>, Madison, WI,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vivien, Denis" sort="Vivien, Denis" uniqKey="Vivien D" first="Denis" last="Vivien">Denis Vivien</name><affiliation wicri:level="1"><nlm:aff id="aff20">Cell Biology and Clinical Research Department, Medical Center,<institution>Université Caen-Normandie</institution>, GIP Cyceron; Inserm, Inserm UMR-S U919, Serine Proteases and Pathophysiology of the neurovascular Unit, Caen,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yepes, Manuel" sort="Yepes, Manuel" uniqKey="Yepes M" first="Manuel" last="Yepes">Manuel Yepes</name><affiliation wicri:level="1"><nlm:aff id="aff21">Department of Neurology,<institution>Emory University</institution>, Atlanta, GA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zille, Marietta" sort="Zille, Marietta" uniqKey="Zille M" first="Marietta" last="Zille">Marietta Zille</name><affiliation wicri:level="1"><nlm:aff id="aff22">Department of Neurology and Neuroscience, The Burke Medical Research Institute,<institution>Weill Medical College of Cornell University</institution>, White Plains, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boltze, Johannes" sort="Boltze, Johannes" uniqKey="Boltze J" first="Johannes" last="Boltze">Johannes Boltze</name><affiliation wicri:level="1"><nlm:aff id="aff23">Department of Medical Cell Technology, Fraunhofer Research Institution for Marine Biotechnology; Institute for Medical and Marine Biotechnology,<institution>University of Lübeck</institution>, Lübeck,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28059802</idno><idno type="pmc">5302043</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302043</idno><idno type="RBID">PMC:5302043</idno><idno type="doi">10.3233/RNN-160690</idno><date when="????">????</date><idno type="wicri:Area/Pmc/Corpus">002D07</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002D07</idno><idno type="wicri:Area/Pmc/Curation">002B57</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002B57</idno><idno type="wicri:Area/Pmc/Checkpoint">002E03</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002E03</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001232</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001232</idno><idno type="wicri:Area/PubMed/Curation">001221</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001221</idno><idno type="wicri:Area/PubMed/Checkpoint">001221</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001221</idno><idno type="wicri:Area/Ncbi/Merge">004130</idno><idno type="wicri:Area/Ncbi/Curation">004130</idno><idno type="wicri:Area/Ncbi/Checkpoint">004130</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recent progress in translational research on neurovascular and neurodegenerative disorders</title><author><name sortKey="Demuth, Hans Ulrich" sort="Demuth, Hans Ulrich" uniqKey="Demuth H" first="Hans-Ulrich" last="Demuth">Hans-Ulrich Demuth</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Drug Design and Target Validation,<institution>Fraunhofer Institute for Cell Therapy and Immunology (IZI-MWT)</institution>, Halle/Saale,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dijkhuizen, Rick M" sort="Dijkhuizen, Rick M" uniqKey="Dijkhuizen R" first="Rick M." last="Dijkhuizen">Rick M. Dijkhuizen</name><affiliation wicri:level="1"><nlm:aff id="aff2">Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences,<institution>University Medical Center Utrecht</institution>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Farr, Tracy D" sort="Farr, Tracy D" uniqKey="Farr T" first="Tracy D." last="Farr">Tracy D. Farr</name><affiliation wicri:level="1"><nlm:aff id="aff3">School of Life Sciences,<institution>University of Nottingham</institution>, Nottingham,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gelderblom, Mathias" sort="Gelderblom, Mathias" uniqKey="Gelderblom M" first="Mathias" last="Gelderblom">Mathias Gelderblom</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Neurology,<institution>University Medical Center Hamburg-Eppendorf</institution>, Hamburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Horsburgh, Karen" sort="Horsburgh, Karen" uniqKey="Horsburgh K" first="Karen" last="Horsburgh">Karen Horsburgh</name><affiliation wicri:level="1"><nlm:aff id="aff5">Centre for Neuroregeneration,<institution>University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Iadecola, Costantino" sort="Iadecola, Costantino" uniqKey="Iadecola C" first="Costantino" last="Iadecola">Costantino Iadecola</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Brain and Mind Research Institute</institution>, Weill Cornell Medicine, New York, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcleod, Damian D" sort="Mcleod, Damian D" uniqKey="Mcleod D" first="Damian D." last="Mcleod">Damian D. Mcleod</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>University of Newcastle</institution>, Hunter Medical Research Institute and Hunter New England Local Health District, Newcastle,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Michalski, Dominik" sort="Michalski, Dominik" uniqKey="Michalski D" first="Dominik" last="Michalski">Dominik Michalski</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Neurology,<institution>University of Leipzig</institution>, Leipzig,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Murphy, Tim H" sort="Murphy, Tim H" uniqKey="Murphy T" first="Tim H." last="Murphy">Tim H. Murphy</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Psychiatry,<institution>University of British Columbia</institution>, Vancouver,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Orbe, Josune" sort="Orbe, Josune" uniqKey="Orbe J" first="Josune" last="Orbe">Josune Orbe</name><affiliation wicri:level="1"><nlm:aff id="aff10">Atherothrombosis Laboratory, Centre for Applied Medical Research,<institution>University of Navarra</institution>, Pamplona,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Otte, Willem M" sort="Otte, Willem M" uniqKey="Otte W" first="Willem M." last="Otte">Willem M. Otte</name><affiliation wicri:level="1"><nlm:aff id="aff2">Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences,<institution>University Medical Center Utrecht</institution>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Pediatric Neurology, Brain Center Rudolf Magnus,<institution>University Medical Center Utrecht</institution>, Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Petzold, Gabor C" sort="Petzold, Gabor C" uniqKey="Petzold G" first="Gabor C." last="Petzold">Gabor C. Petzold</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>German Center for Neurodegenerative Diseases</institution>, Bonn,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Plesnila, Nikolaus" sort="Plesnila, Nikolaus" uniqKey="Plesnila N" first="Nikolaus" last="Plesnila">Nikolaus Plesnila</name><affiliation wicri:level="1"><nlm:aff id="aff13">Institute for Stroke and Dementia Research (ISD),<institution>University of Munich Medical Center</institution>; Munich Cluster of Systems Neurology (Synergy), LMU Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reiser, Georg" sort="Reiser, Georg" uniqKey="Reiser G" first="Georg" last="Reiser">Georg Reiser</name><affiliation wicri:level="1"><nlm:aff id="aff14">Institute for Neurobiochemistry,<institution>University of Magdeburg</institution>, Magdeburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reymann, Klaus G" sort="Reymann, Klaus G" uniqKey="Reymann K" first="Klaus G." last="Reymann">Klaus G. Reymann</name><affiliation wicri:level="1"><nlm:aff id="aff15">Neuropharmacology Lab,<institution>Leibniz Institute for Neurobiology</institution>, Magdeburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rueger, Maria A" sort="Rueger, Maria A" uniqKey="Rueger M" first="Maria A." last="Rueger">Maria A. Rueger</name><affiliation wicri:level="1"><nlm:aff id="aff16">Department of Neurology,<institution>University Hospital of Cologne</institution>, Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saur, Dorothee" sort="Saur, Dorothee" uniqKey="Saur D" first="Dorothee" last="Saur">Dorothee Saur</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Neurology,<institution>University of Leipzig</institution>, Leipzig,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Savitz, Sean I" sort="Savitz, Sean I" uniqKey="Savitz S" first="Sean I." last="Savitz">Sean I. Savitz</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Neurology,<institution>UTHealth Medical School</institution>, Houston, TX,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schilling, Stephan" sort="Schilling, Stephan" uniqKey="Schilling S" first="Stephan" last="Schilling">Stephan Schilling</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Drug Design and Target Validation,<institution>Fraunhofer Institute for Cell Therapy and Immunology (IZI-MWT)</institution>, Halle/Saale,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spratt, Neil J" sort="Spratt, Neil J" uniqKey="Spratt N" first="Neil J." last="Spratt">Neil J. Spratt</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>University of Newcastle</institution>, Hunter Medical Research Institute and Hunter New England Local Health District, Newcastle,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Turner, Renee J" sort="Turner, Renee J" uniqKey="Turner R" first="Renée J." last="Turner">Renée J. Turner</name><affiliation wicri:level="1"><nlm:aff id="aff18">Adelaide Medical School and Adelaide Centre for Neuroscience Research,<institution>The University of Adelaide</institution>, Adelaide,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vemuganti, Raghu" sort="Vemuganti, Raghu" uniqKey="Vemuganti R" first="Raghu" last="Vemuganti">Raghu Vemuganti</name><affiliation wicri:level="1"><nlm:aff id="aff19">Deptartment of Neurological Surgery,<institution>University of Wisconsin and William S. Middleton VA Hospital</institution>, Madison, WI,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vivien, Denis" sort="Vivien, Denis" uniqKey="Vivien D" first="Denis" last="Vivien">Denis Vivien</name><affiliation wicri:level="1"><nlm:aff id="aff20">Cell Biology and Clinical Research Department, Medical Center,<institution>Université Caen-Normandie</institution>, GIP Cyceron; Inserm, Inserm UMR-S U919, Serine Proteases and Pathophysiology of the neurovascular Unit, Caen,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yepes, Manuel" sort="Yepes, Manuel" uniqKey="Yepes M" first="Manuel" last="Yepes">Manuel Yepes</name><affiliation wicri:level="1"><nlm:aff id="aff21">Department of Neurology,<institution>Emory University</institution>, Atlanta, GA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zille, Marietta" sort="Zille, Marietta" uniqKey="Zille M" first="Marietta" last="Zille">Marietta Zille</name><affiliation wicri:level="1"><nlm:aff id="aff22">Department of Neurology and Neuroscience, The Burke Medical Research Institute,<institution>Weill Medical College of Cornell University</institution>, White Plains, NY,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boltze, Johannes" sort="Boltze, Johannes" uniqKey="Boltze J" first="Johannes" last="Boltze">Johannes Boltze</name><affiliation wicri:level="1"><nlm:aff id="aff23">Department of Medical Cell Technology, Fraunhofer Research Institution for Marine Biotechnology; Institute for Medical and Marine Biotechnology,<institution>University of Lübeck</institution>, Lübeck,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Restorative Neurology and Neuroscience</title><idno type="ISSN">0922-6028</idno><idno type="eISSN">1878-3627</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient’s outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms.</p><p>This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurode- and -regeneration to late stage translational or early stage clinical investigations.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Demuth, Hans Ulrich" sort="Demuth, Hans Ulrich" uniqKey="Demuth H" first="Hans-Ulrich" last="Demuth">Hans-Ulrich Demuth</name></noRegion><name sortKey="Boltze, Johannes" sort="Boltze, Johannes" uniqKey="Boltze J" first="Johannes" last="Boltze">Johannes Boltze</name><name sortKey="Gelderblom, Mathias" sort="Gelderblom, Mathias" uniqKey="Gelderblom M" first="Mathias" last="Gelderblom">Mathias Gelderblom</name><name sortKey="Michalski, Dominik" sort="Michalski, Dominik" uniqKey="Michalski D" first="Dominik" last="Michalski">Dominik Michalski</name><name sortKey="Petzold, Gabor C" sort="Petzold, Gabor C" uniqKey="Petzold G" first="Gabor C." last="Petzold">Gabor C. Petzold</name><name sortKey="Plesnila, Nikolaus" sort="Plesnila, Nikolaus" uniqKey="Plesnila N" first="Nikolaus" last="Plesnila">Nikolaus Plesnila</name><name sortKey="Reiser, Georg" sort="Reiser, Georg" uniqKey="Reiser G" first="Georg" last="Reiser">Georg Reiser</name><name sortKey="Reymann, Klaus G" sort="Reymann, Klaus G" uniqKey="Reymann K" first="Klaus G." last="Reymann">Klaus G. Reymann</name><name sortKey="Rueger, Maria A" sort="Rueger, Maria A" uniqKey="Rueger M" first="Maria A." last="Rueger">Maria A. Rueger</name><name sortKey="Saur, Dorothee" sort="Saur, Dorothee" uniqKey="Saur D" first="Dorothee" last="Saur">Dorothee Saur</name><name sortKey="Schilling, Stephan" sort="Schilling, Stephan" uniqKey="Schilling S" first="Stephan" last="Schilling">Stephan Schilling</name></country><country name="Pays-Bas"><noRegion><name sortKey="Dijkhuizen, Rick M" sort="Dijkhuizen, Rick M" uniqKey="Dijkhuizen R" first="Rick M." last="Dijkhuizen">Rick M. Dijkhuizen</name></noRegion><name sortKey="Otte, Willem M" sort="Otte, Willem M" uniqKey="Otte W" first="Willem M." last="Otte">Willem M. Otte</name><name sortKey="Otte, Willem M" sort="Otte, Willem M" uniqKey="Otte W" first="Willem M." last="Otte">Willem M. Otte</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Farr, Tracy D" sort="Farr, Tracy D" uniqKey="Farr T" first="Tracy D." last="Farr">Tracy D. Farr</name></noRegion><name sortKey="Horsburgh, Karen" sort="Horsburgh, Karen" uniqKey="Horsburgh K" first="Karen" last="Horsburgh">Karen Horsburgh</name></country><country name="États-Unis"><noRegion><name sortKey="Iadecola, Costantino" sort="Iadecola, Costantino" uniqKey="Iadecola C" first="Costantino" last="Iadecola">Costantino Iadecola</name></noRegion><name sortKey="Savitz, Sean I" sort="Savitz, Sean I" uniqKey="Savitz S" first="Sean I." last="Savitz">Sean I. Savitz</name><name sortKey="Vemuganti, Raghu" sort="Vemuganti, Raghu" uniqKey="Vemuganti R" first="Raghu" last="Vemuganti">Raghu Vemuganti</name><name sortKey="Yepes, Manuel" sort="Yepes, Manuel" uniqKey="Yepes M" first="Manuel" last="Yepes">Manuel Yepes</name><name sortKey="Zille, Marietta" sort="Zille, Marietta" uniqKey="Zille M" first="Marietta" last="Zille">Marietta Zille</name></country><country name="Australie"><noRegion><name sortKey="Mcleod, Damian D" sort="Mcleod, Damian D" uniqKey="Mcleod D" first="Damian D." last="Mcleod">Damian D. Mcleod</name></noRegion><name sortKey="Spratt, Neil J" sort="Spratt, Neil J" uniqKey="Spratt N" first="Neil J." last="Spratt">Neil J. Spratt</name><name sortKey="Turner, Renee J" sort="Turner, Renee J" uniqKey="Turner R" first="Renée J." last="Turner">Renée J. Turner</name></country><country name="Canada"><noRegion><name sortKey="Murphy, Tim H" sort="Murphy, Tim H" uniqKey="Murphy T" first="Tim H." last="Murphy">Tim H. Murphy</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Orbe, Josune" sort="Orbe, Josune" uniqKey="Orbe J" first="Josune" last="Orbe">Josune Orbe</name></noRegion></country><country name="France"><noRegion><name sortKey="Vivien, Denis" sort="Vivien, Denis" uniqKey="Vivien D" first="Denis" last="Vivien">Denis Vivien</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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