AustralieFrV1, Main, Merge, bibRecord, 00AB96

Can aquatic distribution of human pharmaceuticals be related to pharmacological data?

Identifieur interne : 00AB96 ( Main/Merge ); précédent : 00AB95; suivant : 00AB97

Can aquatic distribution of human pharmaceuticals be related to pharmacological data?

Auteurs : Michael Williams [Australie] ; Carine L. A. Saison [France] ; Desmond B. Williams [Australie] ; Rai S. Kookana [Australie]

Source :

Chemosphere : (Oxford) [ 0045-6535 ] ; 2006.

RBID : Pascal:07-0057848

Descripteurs français

Pascal (Inist)
- Médicament, Médecine, Pollution eau, Devenir polluant, Impact environnement, Evaluation risque, Ecotoxicologie, Partage phase, Coefficient partage, Sorption, Pharmacocinétique.
Wicri :
- topic : Médicament, Médecine.

English descriptors

KwdEn :
- Drug, Ecotoxicology, Environment impact, Medicine, Partition coefficient, Pharmacokinetics, Phase partition, Pollutant behavior, Risk assessment, Sorption, Water pollution.

Abstract

The recognition of pharmaceuticals as significant environmental contaminants has only been a recent phenomenon. Therefore there is a paucity of data relating to the fate and effects of pharmaceuticals once they enter an aquatic receiving system. The amount of work that needs to be done in terms of risk assessment for pharmaceuticals required by regulatory agencies is substantial. This paper has determined the environmental partitioning coefficient (K_d) of 13 diverse human pharmaceuticals in three model systems of differing combinations of solid phases and solutions. The K_d values were then compared with distribution values of the pharmaceuticals in the human body determined from pharmacological studies. This was done to assess the functional relationship between K_d and distribution values in the human body (V_D). K_d values ranged from 3 to 2450 L kg^-1. Regression coefficients ranged from r² = 0.62-0.72, indicating that V_D values are a useful indicator for the K_d values of the tested pharmaceuticals within the batch sorption systems. The relationship between K_d and V_D should therefore be further explored to determine whether this relationship can be applied to a broader range of pharmaceuticals in more diverse environmental systems. Exploiting available human pharmacological data in such a way would be of great benefit in prioritising human pharmaceuticals as environmental contaminants in the risk assessment process.

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Pascal:07-0057848

Le document en format XML

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<author><name sortKey="Saison, Carine L A" sort="Saison, Carine L A" uniqKey="Saison C" first="Carine L. A." last="Saison">Carine L. A. Saison</name>
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<author><name sortKey="Williams, Desmond B" sort="Williams, Desmond B" uniqKey="Williams D" first="Desmond B." last="Williams">Desmond B. Williams</name>
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<term>Partition coefficient</term>
<term>Pharmacokinetics</term>
<term>Phase partition</term>
<term>Pollutant behavior</term>
<term>Risk assessment</term>
<term>Sorption</term>
<term>Water pollution</term>
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<term>Impact environnement</term>
<term>Evaluation risque</term>
<term>Ecotoxicologie</term>
<term>Partage phase</term>
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<front><div type="abstract" xml:lang="en">The recognition of pharmaceuticals as significant environmental contaminants has only been a recent phenomenon. Therefore there is a paucity of data relating to the fate and effects of pharmaceuticals once they enter an aquatic receiving system. The amount of work that needs to be done in terms of risk assessment for pharmaceuticals required by regulatory agencies is substantial. This paper has determined the environmental partitioning coefficient (K<sub>d</sub>
) of 13 diverse human pharmaceuticals in three model systems of differing combinations of solid phases and solutions. The K<sub>d</sub>
 values were then compared with distribution values of the pharmaceuticals in the human body determined from pharmacological studies. This was done to assess the functional relationship between K<sub>d</sub>
 and distribution values in the human body (V<sub>D</sub>
). K<sub>d</sub>
 values ranged from 3 to 2450 L kg<sup>-1</sup>
. Regression coefficients ranged from r<sup>2</sup>
 = 0.62-0.72, indicating that V<sub>D</sub>
 values are a useful indicator for the K<sub>d</sub>
 values of the tested pharmaceuticals within the batch sorption systems. The relationship between K<sub>d</sub>
 and V<sub>D</sub>
 should therefore be further explored to determine whether this relationship can be applied to a broader range of pharmaceuticals in more diverse environmental systems. Exploiting available human pharmacological data in such a way would be of great benefit in prioritising human pharmaceuticals as environmental contaminants in the risk assessment process.</div>
</front>
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<name sortKey="Kookana, Rai S" sort="Kookana, Rai S" uniqKey="Kookana R" first="Rai S." last="Kookana">Rai S. Kookana</name>
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<name sortKey="Williams, Desmond B" sort="Williams, Desmond B" uniqKey="Williams D" first="Desmond B." last="Williams">Desmond B. Williams</name>
<name sortKey="Williams, Michael" sort="Williams, Michael" uniqKey="Williams M" first="Michael" last="Williams">Michael Williams</name>
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<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Saison, Carine L A" sort="Saison, Carine L A" uniqKey="Saison C" first="Carine L. A." last="Saison">Carine L. A. Saison</name>
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Can aquatic distribution of human pharmaceuticals be related to pharmacological data?

Can aquatic distribution of human pharmaceuticals be related to pharmacological data?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri