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Implications of modifying the duration requirement of generalized anxiety disorder in developed and developing countries

Identifieur interne : 009062 ( Main/Merge ); précédent : 009061; suivant : 009063

Implications of modifying the duration requirement of generalized anxiety disorder in developed and developing countries

Auteurs : S. Lee [États-Unis, Hong Kong] ; A. Tsang [États-Unis] ; A. M. Ruscio [États-Unis] ; J. M. Haro [Espagne] ; D. J. Stein [Afrique du Sud] ; J. Alonso [Espagne] ; M. C. Angermeyer [Autriche] ; E. J. Bromet [États-Unis] ; K. Demyttenaere [Belgique] ; G. De Girolamo [Italie] ; R. De Graaf [Pays-Bas] ; O. Gureje [Nigeria] ; N. Iwata [Japon] ; E. G. Karam [Liban] ; J.-P. Lepine [France] ; D. Levinson [Israël] ; M. E. Medina-Mora [Mexique] ; M. A. Oakley Browne [Australie] ; J. Posada-Villa [Colombie] ; R. C. Kessler [États-Unis]

Source :

RBID : ISTEX:4F93AABE18860B0848DA4773EBA87E3BB997AF89

Abstract

Background A number of western studies have suggested that the 6-month duration requirement of generalized anxiety disorder (GAD) does not represent a critical threshold in terms of onset, course, or risk factors of the disorder. No study has examined the consequences of modifying the duration requirement across a wide range of correlates in both developed and developing countries. Method Population surveys were carried out in seven developing and 10 developed countries using the WHO Composite International Diagnostic Interview (total sample=85 052). Prevalence and correlates of GAD were compared across mutually exclusive GAD subgroups defined by different minimum duration criteria. Results Lifetime prevalence estimates for GAD lasting 1 month, 3 months, 6 months and 12 months were 7.5%, 5.2%, 4.1% and 3.0% for developed countries and 2.7%, 1.8%, 1.5% and 1.2% for developing countries, respectively. There was little difference between GAD of 6 months' duration and GAD of shorter durations (1–2 months, 3–5 months) in age of onset, symptom severity or persistence, co-morbidity or impairment. GAD lasting ⩾12 months was the most severe, persistently symptomatic and impaired subgroup. Conclusions In both developed and developing countries, the clinical profile of GAD is similar regardless of duration. The DSM-IV 6-month duration criterion excludes a large number of individuals who present with shorter generalized anxiety episodes which may be recurrent, impairing and contributory to treatment-seeking. Future iterations of the DSM and ICD should consider modifying the 6-month duration criterion so as to better capture the diversity of clinically salient anxiety presentations.

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DOI: 10.1017/S0033291708004807

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<div type="abstract">Background A number of western studies have suggested that the 6-month duration requirement of generalized anxiety disorder (GAD) does not represent a critical threshold in terms of onset, course, or risk factors of the disorder. No study has examined the consequences of modifying the duration requirement across a wide range of correlates in both developed and developing countries. Method Population surveys were carried out in seven developing and 10 developed countries using the WHO Composite International Diagnostic Interview (total sample=85 052). Prevalence and correlates of GAD were compared across mutually exclusive GAD subgroups defined by different minimum duration criteria. Results Lifetime prevalence estimates for GAD lasting 1 month, 3 months, 6 months and 12 months were 7.5%, 5.2%, 4.1% and 3.0% for developed countries and 2.7%, 1.8%, 1.5% and 1.2% for developing countries, respectively. There was little difference between GAD of 6 months' duration and GAD of shorter durations (1–2 months, 3–5 months) in age of onset, symptom severity or persistence, co-morbidity or impairment. GAD lasting ⩾12 months was the most severe, persistently symptomatic and impaired subgroup. Conclusions In both developed and developing countries, the clinical profile of GAD is similar regardless of duration. The DSM-IV 6-month duration criterion excludes a large number of individuals who present with shorter generalized anxiety episodes which may be recurrent, impairing and contributory to treatment-seeking. Future iterations of the DSM and ICD should consider modifying the 6-month duration criterion so as to better capture the diversity of clinically salient anxiety presentations.</div>
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<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Psychiatry, University College Hospital, Ibadan</wicri:regionArea>
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<wicri:regionArea>Hiroshima International University, Higashi-Hiroshima</wicri:regionArea>
<wicri:noRegion>Higashi-Hiroshima</wicri:noRegion>
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<wicri:regionArea>Institute for Development, Research, Advocacy, and Applied Care (IDRAAC), St. George Hospital University Medical Center, Beirut</wicri:regionArea>
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<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<wicri:regionArea>Colegio Mayor de Cundinamarca University, Bogotá</wicri:regionArea>
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<name sortKey="Kessler, R C" sort="Kessler, R C" uniqKey="Kessler R" first="R. C." last="Kessler">R. C. Kessler</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Care Policy, Harvard Medical School, Boston</wicri:regionArea>
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<div type="abstract">Background A number of western studies have suggested that the 6-month duration requirement of generalized anxiety disorder (GAD) does not represent a critical threshold in terms of onset, course, or risk factors of the disorder. No study has examined the consequences of modifying the duration requirement across a wide range of correlates in both developed and developing countries. Method Population surveys were carried out in seven developing and 10 developed countries using the WHO Composite International Diagnostic Interview (total sample=85 052). Prevalence and correlates of GAD were compared across mutually exclusive GAD subgroups defined by different minimum duration criteria. Results Lifetime prevalence estimates for GAD lasting 1 month, 3 months, 6 months and 12 months were 7.5%, 5.2%, 4.1% and 3.0% for developed countries and 2.7%, 1.8%, 1.5% and 1.2% for developing countries, respectively. There was little difference between GAD of 6 months' duration and GAD of shorter durations (1–2 months, 3–5 months) in age of onset, symptom severity or persistence, co-morbidity or impairment. GAD lasting ⩾12 months was the most severe, persistently symptomatic and impaired subgroup. Conclusions In both developed and developing countries, the clinical profile of GAD is similar regardless of duration. The DSM-IV 6-month duration criterion excludes a large number of individuals who present with shorter generalized anxiety episodes which may be recurrent, impairing and contributory to treatment-seeking. Future iterations of the DSM and ICD should consider modifying the 6-month duration criterion so as to better capture the diversity of clinically salient anxiety presentations.</div>
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<name sortKey="Tsang, Adley" sort="Tsang, Adley" uniqKey="Tsang A" first="Adley" last="Tsang">Adley Tsang</name>
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<name sortKey="Demyttenaere, Koen" sort="Demyttenaere, Koen" uniqKey="Demyttenaere K" first="Koen" last="Demyttenaere">Koen Demyttenaere</name>
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<name sortKey="Levinson, Daphna" sort="Levinson, Daphna" uniqKey="Levinson D" first="Daphna" last="Levinson">Daphna Levinson</name>
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<name sortKey="Medina Mora, Maria Elena" sort="Medina Mora, Maria Elena" uniqKey="Medina Mora M" first="Maria Elena" last="Medina-Mora">Maria Elena Medina-Mora</name>
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<div type="abstract" xml:lang="en">
<sec id="S16">
<title>Background</title>
<p id="P1">A number of western studies have suggested that the 6-month duration requirement of generalized anxiety disorder (GAD) does not represent a critical threshold in terms of onset, course, or risk factors of the disorder. No study has examined the consequences of modifying the duration requirement across a wide range of correlates in both developed and developing countries.</p>
</sec>
<sec sec-type="methods" id="S17">
<title>Methods</title>
<p id="P2">Population surveys were carried out in 7 developing and 10 developed countries using the WHO Composite International Diagnostic Interview (total sample size = 85,052). Prevalence of GAD was estimated using different minimum duration criteria. Age of onset, symptom persistence, subsequent mental disorders, impairment, and recovery were compared across GAD subgroups defined by different duration criteria.</p>
</sec>
<sec id="S18">
<title>Results</title>
<p id="P3">Lifetime prevalence estimates for GAD lasting 1 month, 3 months, 6 months, and 12 months were 7.5%, 5.24%, 4.11%, and 2.95% for developed countries and 2.65%, 1.78%, 1.47%, and 1.17% for developing countries, respectively. There was little difference between GAD of 6 months duration and GAD of shorter durations (1–2 months, 3–5 months) in symptom severity, age of onset, persistence, impairment, or comorbidity. Those with GAD lasting 12 months or more were the most severe, chronic, and impaired of the four duration subgroups.</p>
</sec>
<sec id="S19">
<title>Conclusion</title>
<p id="P4">In both developed and developing countries, the clinical profile of GAD is similar regardless of duration. The DSM-IV 6-month duration criterion is not an optimal marker of severity, impairment, or need for early treatment. Future iterations of the DSM and ICD should consider shortening the duration requirement of GAD.</p>
</sec>
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