A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants
Identifieur interne : 007559 ( Main/Merge ); précédent : 007558; suivant : 007560A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants
Auteurs : E. Theodoratou [Royaume-Uni] ; H. Campbell [Royaume-Uni] ; A. Tenesa [Royaume-Uni] ; R. Houlston [Royaume-Uni] ; E. Webb [Royaume-Uni] ; S. Lubbe [Royaume-Uni] ; P. Broderick [Royaume-Uni] ; S. Gallinger [Canada] ; E M Croitoru [Canada] ; M A Jenkins [Australie] ; A K Win [Australie] ; S P Cleary [Canada] ; T. Koessler [Royaume-Uni] ; P D Pharoah [Royaume-Uni] ; S. Küry [France] ; S. Bézieau [France] ; B. Buecher [France] ; N A Ellis [États-Unis] ; P. Peterlongo [Italie] ; K. Offit [États-Unis] ; L A Aaltonen [Finlande] ; S. Enholm [Finlande] ; A. Lindblom [Suède] ; X-L Zhou [Suède] ; I P Tomlinson [Royaume-Uni] ; V. Moreno [Espagne] ; I. Blanco [Espagne] ; G. Capellà [Espagne] ; R. Barnetson [Royaume-Uni] ; M E Porteous [Royaume-Uni] ; M G Dunlop [Royaume-Uni] ; S M Farrington [Royaume-Uni]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2010.
Abstract
Defective DNA repair has a causal role in hereditary colorectal cancer (CRC). Defects in the base excision repair gene
All three models produced very similar results.
Overall, this large study refines estimates of disease risk associated with mono-allelic and bi-allelic
Url:
DOI: 10.1038/sj.bjc.6605966
PubMed: 21063410
PubMed Central: 3008602
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Koessler</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Strangeways Research Laboratory, Department of Oncology and Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, P D" sort="Pharoah, P D" uniqKey="Pharoah P" first="P D" last="Pharoah">P D Pharoah</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Strangeways Research Laboratory, Department of Oncology and Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kury, S" sort="Kury, S" uniqKey="Kury S" first="S" last="Küry">S. Küry</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>CHU de Nantes, pôle de Biologie, service de Génétique Médicale</institution>, 9 quai Moncousu, Nantes, 44093 cedex 1,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bezieau, S" sort="Bezieau, S" uniqKey="Bezieau S" first="S" last="Bézieau">S. Bézieau</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>CHU de Nantes, pôle de Biologie, service de Génétique Médicale</institution>, 9 quai Moncousu, Nantes, 44093 cedex 1,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buecher, B" sort="Buecher, B" uniqKey="Buecher B" first="B" last="Buecher">B. Buecher</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>unité de Génétique Constitutionnelle, Institut Curie, service de Génétique Oncologique</institution>, 26 rue d'Ulm, Paris, 75248 cedex 05,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ellis, N A" sort="Ellis, N A" uniqKey="Ellis N" first="N A" last="Ellis">N A Ellis</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>University of Chicago</institution>, 900 East 57th Street, Chicago, IL 60637,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, and Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Offit, K" sort="Offit, K" uniqKey="Offit K" first="K" last="Offit">K. Offit</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Clinical Cancer Genetics, Memorial Sloan-Kettering Cancer Centre</institution>, New York,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aaltonen, L A" sort="Aaltonen, L A" uniqKey="Aaltonen L" first="L A" last="Aaltonen">L A Aaltonen</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki</institution>, PO Box 63 (Haartmaninkatu 8), FIN-00014,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Enholm, S" sort="Enholm, S" uniqKey="Enholm S" first="S" last="Enholm">S. Enholm</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki</institution>, PO Box 63 (Haartmaninkatu 8), FIN-00014,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, A" sort="Lindblom, A" uniqKey="Lindblom A" first="A" last="Lindblom">A. Lindblom</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Molecular Medicine and Surgery Karolinska Institute and Department of Clinical Genetics Karolinska University Hospital</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, X L" sort="Zhou, X L" uniqKey="Zhou X" first="X-L" last="Zhou">X-L Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Molecular Medicine and Surgery Karolinska Institute and Department of Clinical Genetics Karolinska University Hospital</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, I P" sort="Tomlinson, I P" uniqKey="Tomlinson I" first="I P" last="Tomlinson">I P Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moreno, V" sort="Moreno, V" uniqKey="Moreno V" first="V" last="Moreno">V. Moreno</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Catalan Institute of Oncology-ICO, IDIBELL and University of Barcelona</institution>, Av Gran Via 199, L'Hospitalet, Barcelona 08907,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, I" sort="Blanco, I" uniqKey="Blanco I" first="I" last="Blanco">I. Blanco</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Catalan Institute of Oncology-ICO, IDIBELL and University of Barcelona</institution>, Av Gran Via 199, L'Hospitalet, Barcelona 08907,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Capella, G" sort="Capella, G" uniqKey="Capella G" first="G" last="Capellà">G. Capellà</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Catalan Institute of Oncology-ICO, IDIBELL and University of Barcelona</institution>, Av Gran Via 199, L'Hospitalet, Barcelona 08907,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barnetson, R" sort="Barnetson, R" uniqKey="Barnetson R" first="R" last="Barnetson">R. Barnetson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Colon Cancer Genetics Group and Academic Coloproctology, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Porteous, M E" sort="Porteous, M E" uniqKey="Porteous M" first="M E" last="Porteous">M E Porteous</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Colon Cancer Genetics Group and Academic Coloproctology, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Southeast of Scotland Clinical Genetic Services, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dunlop, M G" sort="Dunlop, M G" uniqKey="Dunlop M" first="M G" last="Dunlop">M G Dunlop</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Colon Cancer Genetics Group and Academic Coloproctology, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Farrington, S M" sort="Farrington, S M" uniqKey="Farrington S" first="S M" last="Farrington">S M Farrington</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Colon Cancer Genetics Group and Academic Coloproctology, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21063410</idno><idno type="pmc">3008602</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008602</idno><idno type="RBID">PMC:3008602</idno><idno type="doi">10.1038/sj.bjc.6605966</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000088</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000088</idno><idno type="wicri:Area/Pmc/Curation">000088</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000088</idno><idno type="wicri:Area/Pmc/Checkpoint">002673</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002673</idno><idno type="wicri:Area/Ncbi/Merge">000918</idno><idno type="wicri:Area/Ncbi/Curation">000918</idno><idno type="wicri:Area/Ncbi/Checkpoint">000918</idno><idno type="wicri:doubleKey">0007-0920:2010:Theodoratou E:a:large:scale</idno><idno type="wicri:Area/Main/Merge">007559</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A large-scale meta-analysis to refine colorectal cancer risk estimates associated with <italic>MUTYH</italic> variants</title><author><name sortKey="Theodoratou, E" sort="Theodoratou, E" uniqKey="Theodoratou E" first="E" last="Theodoratou">E. Theodoratou</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Colon Cancer Genetics Group and Academic Coloproctology, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Public Health Sciences, University of Edinburgh, Teviot Place</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, H" sort="Campbell, H" uniqKey="Campbell H" first="H" last="Campbell">H. Campbell</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Colon Cancer Genetics Group and Academic Coloproctology, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Public Health Sciences, University of Edinburgh, Teviot Place</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tenesa, A" sort="Tenesa, A" uniqKey="Tenesa A" first="A" last="Tenesa">A. Tenesa</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Colon Cancer Genetics Group and Academic Coloproctology, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Houlston, R" sort="Houlston, R" uniqKey="Houlston R" first="R" last="Houlston">R. Houlston</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Section of Cancer Genetics, Institute of Cancer Research</institution>, Sutton, Surrey,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Webb, E" sort="Webb, E" uniqKey="Webb E" first="E" last="Webb">E. Webb</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Section of Cancer Genetics, Institute of Cancer Research</institution>, Sutton, Surrey,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lubbe, S" sort="Lubbe, S" uniqKey="Lubbe S" first="S" last="Lubbe">S. Lubbe</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Section of Cancer Genetics, Institute of Cancer Research</institution>, Sutton, Surrey,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broderick, P" sort="Broderick, P" uniqKey="Broderick P" first="P" last="Broderick">P. Broderick</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Section of Cancer Genetics, Institute of Cancer Research</institution>, Sutton, Surrey,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S" last="Gallinger">S. Gallinger</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Ontario Familial Colorectal Cancer Registry</institution>, Toronto, Ontario,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Croitoru, E M" sort="Croitoru, E M" uniqKey="Croitoru E" first="E M" last="Croitoru">E M Croitoru</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jenkins, M A" sort="Jenkins, M A" uniqKey="Jenkins M" first="M A" last="Jenkins">M A Jenkins</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne</institution>, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Win, A K" sort="Win, A K" uniqKey="Win A" first="A K" last="Win">A K Win</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne</institution>, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cleary, S P" sort="Cleary, S P" uniqKey="Cleary S" first="S P" last="Cleary">S P Cleary</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Koessler, T" sort="Koessler, T" uniqKey="Koessler T" first="T" last="Koessler">T. Koessler</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Strangeways Research Laboratory, Department of Oncology and Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, P D" sort="Pharoah, P D" uniqKey="Pharoah P" first="P D" last="Pharoah">P D Pharoah</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Strangeways Research Laboratory, Department of Oncology and Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kury, S" sort="Kury, S" uniqKey="Kury S" first="S" last="Küry">S. Küry</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>CHU de Nantes, pôle de Biologie, service de Génétique Médicale</institution>, 9 quai Moncousu, Nantes, 44093 cedex 1,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bezieau, S" sort="Bezieau, S" uniqKey="Bezieau S" first="S" last="Bézieau">S. Bézieau</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>CHU de Nantes, pôle de Biologie, service de Génétique Médicale</institution>, 9 quai Moncousu, Nantes, 44093 cedex 1,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buecher, B" sort="Buecher, B" uniqKey="Buecher B" first="B" last="Buecher">B. Buecher</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>unité de Génétique Constitutionnelle, Institut Curie, service de Génétique Oncologique</institution>, 26 rue d'Ulm, Paris, 75248 cedex 05,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ellis, N A" sort="Ellis, N A" uniqKey="Ellis N" first="N A" last="Ellis">N A Ellis</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>University of Chicago</institution>, 900 East 57th Street, Chicago, IL 60637,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, and Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Offit, K" sort="Offit, K" uniqKey="Offit K" first="K" last="Offit">K. Offit</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Clinical Cancer Genetics, Memorial Sloan-Kettering Cancer Centre</institution>, New York,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aaltonen, L A" sort="Aaltonen, L A" uniqKey="Aaltonen L" first="L A" last="Aaltonen">L A Aaltonen</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki</institution>, PO Box 63 (Haartmaninkatu 8), FIN-00014,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Enholm, S" sort="Enholm, S" uniqKey="Enholm S" first="S" last="Enholm">S. Enholm</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki</institution>, PO Box 63 (Haartmaninkatu 8), FIN-00014,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, A" sort="Lindblom, A" uniqKey="Lindblom A" first="A" last="Lindblom">A. Lindblom</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Molecular Medicine and Surgery Karolinska Institute and Department of Clinical Genetics Karolinska University Hospital</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, X L" sort="Zhou, X L" uniqKey="Zhou X" first="X-L" last="Zhou">X-L Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Molecular Medicine and Surgery Karolinska Institute and Department of Clinical Genetics Karolinska University Hospital</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, I P" sort="Tomlinson, I P" uniqKey="Tomlinson I" first="I P" last="Tomlinson">I P Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moreno, V" sort="Moreno, V" uniqKey="Moreno V" first="V" last="Moreno">V. Moreno</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Catalan Institute of Oncology-ICO, IDIBELL and University of Barcelona</institution>, Av Gran Via 199, L'Hospitalet, Barcelona 08907,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, I" sort="Blanco, I" uniqKey="Blanco I" first="I" last="Blanco">I. Blanco</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Catalan Institute of Oncology-ICO, IDIBELL and University of Barcelona</institution>, Av Gran Via 199, L'Hospitalet, Barcelona 08907,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Capella, G" sort="Capella, G" uniqKey="Capella G" first="G" last="Capellà">G. Capellà</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Catalan Institute of Oncology-ICO, IDIBELL and University of Barcelona</institution>, Av Gran Via 199, L'Hospitalet, Barcelona 08907,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barnetson, R" sort="Barnetson, R" uniqKey="Barnetson R" first="R" last="Barnetson">R. Barnetson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Colon Cancer Genetics Group and Academic Coloproctology, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Porteous, M E" sort="Porteous, M E" uniqKey="Porteous M" first="M E" last="Porteous">M E Porteous</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Colon Cancer Genetics Group and Academic Coloproctology, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Southeast of Scotland Clinical Genetic Services, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dunlop, M G" sort="Dunlop, M G" uniqKey="Dunlop M" first="M G" last="Dunlop">M G Dunlop</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Colon Cancer Genetics Group and Academic Coloproctology, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Farrington, S M" sort="Farrington, S M" uniqKey="Farrington S" first="S M" last="Farrington">S M Farrington</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Colon Cancer Genetics Group and Academic Coloproctology, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Defective DNA repair has a causal role in hereditary colorectal cancer (CRC). Defects in the base excision repair gene <italic>MUTYH</italic> are responsible for <italic>MUTYH</italic>-associated polyposis and CRC predisposition as an autosomal recessive trait. Numerous reports have suggested <italic>MUTYH</italic> mono-allelic variants to be low penetrance risk alleles. We report a large collaborative meta-analysis to assess and refine CRC risk estimates associated with bi-allelic and mono-allelic <italic>MUTYH</italic> variants and investigate age and sex influence on risk.</p></sec><sec><title>Methods:</title><p><italic>MUTYH</italic> genotype data were included from 20 565 cases and 15 524 controls. Three logistic regression models were tested: a crude model; adjusted for age and sex; adjusted for age, sex and study.</p></sec><sec><title>Results:</title><p>All three models produced very similar results. <italic>MUTYH</italic> bi-allelic carriers demonstrated a 28-fold increase in risk (95% confidence interval (CI): 6.95–115). Significant bi-allelic effects were also observed for G396D and Y179C/G396D compound heterozygotes and a marginal mono-allelic effect for variant Y179C (odds ratio (OR)=1.34; 95% CI: 1.00–1.80). A pooled meta-analysis of all published and unpublished datasets submitted showed bi-allelic effects for <italic>MUTYH</italic>, G396D and Y179C (OR=10.8, 95% CI: 5.02–23.2; OR=6.47, 95% CI: 2.33–18.0; OR=3.35, 95% CI: 1.14–9.89) and marginal mono-allelic effect for variants <italic>MUTYH</italic> (OR=1.16, 95% CI: 1.00–1.34) and Y179C alone (OR=1.34, 95% CI: 1.01–1.77).</p></sec><sec><title>Conclusions:</title><p>Overall, this large study refines estimates of disease risk associated with mono-allelic and bi-allelic <italic>MUTYH</italic> carriers.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Al Tassan, N" uniqKey="Al Tassan N">N Al-Tassan</name></author><author><name sortKey="Chmiel, Nh" uniqKey="Chmiel N">NH Chmiel</name></author><author><name sortKey="Maynard, J" uniqKey="Maynard J">J Maynard</name></author><author><name sortKey="Fleming, N" uniqKey="Fleming N">N Fleming</name></author><author><name 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Houlston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, X L" uniqKey="Zhou X">X-L Zhou</name></author><author><name sortKey="Djureinovic, T" uniqKey="Djureinovic T">T Djureinovic</name></author><author><name sortKey="Werelius, B" uniqKey="Werelius B">B Werelius</name></author><author><name sortKey="Lindmark, G" uniqKey="Lindmark G">G Lindmark</name></author><author><name sortKey="Sun, Xf" uniqKey="Sun X">XF Sun</name></author><author><name sortKey="Lindblom, A" uniqKey="Lindblom A">A Lindblom</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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