Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study12345
Identifieur interne : 004701 ( Main/Merge ); précédent : 004700; suivant : 004702Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study12345
Auteurs : Ho-Sun Lee ; Albino Barraza-Villarreal ; Hector Hernandez-Vargas ; Peter D. Sly ; Carine Biessy ; Usha Ramakrishnan ; Isabelle Romieu ; Zdenko HercegSource :
- The American Journal of Clinical Nutrition [ 0002-9165 ] ; 2013.
Abstract
Url:
DOI: 10.3945/ajcn.112.052241
PubMed: 23761484
PubMed Central: 3712555
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<author><name sortKey="Lee, Ho Sun" sort="Lee, Ho Sun" uniqKey="Lee H" first="Ho-Sun" last="Lee">Ho-Sun Lee</name>
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<author><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name>
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<author><name sortKey="Hernandez Vargas, Hector" sort="Hernandez Vargas, Hector" uniqKey="Hernandez Vargas H" first="Hector" last="Hernandez-Vargas">Hector Hernandez-Vargas</name>
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<author><name sortKey="Sly, Peter D" sort="Sly, Peter D" uniqKey="Sly P" first="Peter D" last="Sly">Peter D. Sly</name>
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<author><name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name>
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<author><name sortKey="Ramakrishnan, Usha" sort="Ramakrishnan, Usha" uniqKey="Ramakrishnan U" first="Usha" last="Ramakrishnan">Usha Ramakrishnan</name>
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<author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name>
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<author><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study<xref ref-type="aff" rid="aff1"><sup>1</sup>
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<author><name sortKey="Lee, Ho Sun" sort="Lee, Ho Sun" uniqKey="Lee H" first="Ho-Sun" last="Lee">Ho-Sun Lee</name>
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<author><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name>
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<author><name sortKey="Hernandez Vargas, Hector" sort="Hernandez Vargas, Hector" uniqKey="Hernandez Vargas H" first="Hector" last="Hernandez-Vargas">Hector Hernandez-Vargas</name>
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<author><name sortKey="Sly, Peter D" sort="Sly, Peter D" uniqKey="Sly P" first="Peter D" last="Sly">Peter D. Sly</name>
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<author><name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name>
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<author><name sortKey="Ramakrishnan, Usha" sort="Ramakrishnan, Usha" uniqKey="Ramakrishnan U" first="Usha" last="Ramakrishnan">Usha Ramakrishnan</name>
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<author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name>
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<author><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name>
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<series><title level="j">The American Journal of Clinical Nutrition</title>
<idno type="ISSN">0002-9165</idno>
<idno type="eISSN">1938-3207</idno>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
Early-life exposures to tobacco smoke and some dietary factors have been identified to induce epigenetic changes in genes involved in allergy and asthma development. Omega-3 (n−3) polyunsaturated fatty acid (PUFA) intake during pregnancy could modulate key cytokines and T helper (Th) cell maturation; however, little is known about the mechanism by which ω-3 PUFA could have a beneficial effect in preventing inflammatory disorders.</p>
<p><bold>Objective:</bold>
We sought to test whether prenatal dietary supplementation with ω-3 PUFA during pregnancy may modulate epigenetic states in the infant immune system.</p>
<p><bold>Design:</bold>
This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg docosahexaenoic acid (DHA) or a placebo from 18 to 22 wk of gestation to parturition. We applied quantitative profiling of DNA methylation states in Th1, Th2, Th17, and regulatory T–relevant genes as well as <italic>LINE1</italic>
repetitive elements of cord blood mononuclear cells (<italic>n</italic>
= 261).</p>
<p><bold>Results:</bold>
No significant difference in promoter methylation levels was shown between ω-3 PUFA–supplemented and control groups for the genes analyzed; however, ω-3 PUFA supplementation was associated with changes in methylation levels in <italic>LINE1</italic>
repetitive elements (<italic>P</italic>
= 0.03) in infants of mothers who smoked during pregnancy. Furthermore, an association between the promoter methylation levels of <italic>IFNγ</italic>
and <italic>IL13</italic>
was modulated by ω-3 PUFA supplementation (<italic>P</italic>
= 0.06).</p>
<p><bold>Conclusions:</bold>
Our results indicate that maternal supplementation with ω-3 PUFA during pregnancy may modulate global methylation levels and the Th1/Th2 balance in infants. Therefore, the epigenetic mechanisms could provide attractive targets for prenatal modulation and prevention of inflammatory disorders and potentially other related diseases in childhood and adulthood.</p>
</div>
</front>
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