Proceedings: Human Leukocyte Antigen Haplo-Homozygous Induced Pluripotent Stem Cell Haplobank Modeled After the California Population: Evaluating Matching in a Multiethnic and Admixed Population
Identifieur interne : 002963 ( Main/Merge ); précédent : 002962; suivant : 002964Proceedings: Human Leukocyte Antigen Haplo-Homozygous Induced Pluripotent Stem Cell Haplobank Modeled After the California Population: Evaluating Matching in a Multiethnic and Admixed Population
Auteurs : Derek James Pappas [France, États-Unis] ; Pierre-Antoine Gourraud [France, États-Unis] ; Caroline Le Gall [France] ; Julie Laurent [France] ; Alan Trounson [États-Unis, Australie] ; Natalie Dewitt [États-Unis, Australie] ; Sohel Talib [États-Unis]Source :
- Stem Cells Translational Medicine [ 2157-6564 ] ; 2015.
Descripteurs français
- KwdFr :
- Antigènes HLA (génétique), Californie, Cellules souches pluripotentes induites (cytologie), Donneurs de tissus, Groupes ethniques (génétique), Génotype, Génétique des populations, Haplotypes (génétique), Homozygote, Humains, Lignée cellulaire, Recherche sur les cellules souches, Test d'histocompatibilité.
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : HLA Antigens.
- geographic : California.
- cytology : Induced Pluripotent Stem Cells.
- genetics : Ethnic Groups, Haplotypes.
- Cell Line, Genetics, Population, Genotype, Histocompatibility Testing, Homozygote, Humans, Stem Cell Research, Tissue Donors.
Abstract
This study developed a new model for evaluating an induced pluripotent stem cell (iPSC) haplobank based on demographic and immunogenetic characteristics reflecting California. Creation of a haplobank of iPSC lines homozygous for a variety of human leukocyte antigen (HLA) types, representative of different geographic populations and ethnic groups, could simplify HLA matching and provide matches for reasonable percentages of target populations and extend iPSC-derived therapies beyond the autologous setting.
Url:
DOI: 10.5966/sctm.2015-0052
PubMed: 25926330
PubMed Central: 4414226
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first="Caroline" last="Le Gall">Caroline Le Gall</name><affiliation wicri:level="1"><nlm:aff id="aff1">Methodomics, Mortagne-sur-Sevre, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Methodomics, Mortagne-sur-Sevre</wicri:regionArea><wicri:noRegion>Mortagne-sur-Sevre</wicri:noRegion><wicri:noRegion>Mortagne-sur-Sevre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Institut Sup’Biotech, Villejuif, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Sup’Biotech, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Laurent, Julie" sort="Laurent, Julie" uniqKey="Laurent J" first="Julie" last="Laurent">Julie Laurent</name><affiliation wicri:level="1"><nlm:aff id="aff1">Methodomics, Mortagne-sur-Sevre, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Methodomics, 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Research (Hudson Institute), Monash Medical Centre, Melbourne, Victoria, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Prince Henry’s Institute for Medical Research (Hudson Institute), Monash Medical Centre, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff7">Baxter Laboratory for Stem Cell Research, Stanford University, Stanford, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory for Stem Cell Research, Stanford University, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Talib, Sohel" sort="Talib, Sohel" uniqKey="Talib S" first="Sohel" last="Talib">Sohel Talib</name><affiliation wicri:level="2"><nlm:aff id="aff5">California Institute for Regenerative Medicine, San Francisco, California, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>California Institute for Regenerative Medicine, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Stem Cells Translational Medicine</title><idno type="ISSN">2157-6564</idno><idno type="eISSN">2157-6580</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>California</term><term>Cell Line</term><term>Ethnic Groups (genetics)</term><term>Genetics, Population</term><term>Genotype</term><term>HLA Antigens (genetics)</term><term>Haplotypes (genetics)</term><term>Histocompatibility Testing</term><term>Homozygote</term><term>Humans</term><term>Induced Pluripotent Stem Cells (cytology)</term><term>Stem Cell Research</term><term>Tissue Donors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes HLA (génétique)</term><term>Californie</term><term>Cellules souches pluripotentes induites (cytologie)</term><term>Donneurs de tissus</term><term>Groupes ethniques (génétique)</term><term>Génotype</term><term>Génétique des populations</term><term>Haplotypes (génétique)</term><term>Homozygote</term><term>Humains</term><term>Lignée cellulaire</term><term>Recherche sur les cellules souches</term><term>Test d'histocompatibilité</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA Antigens</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>California</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches pluripotentes induites</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Induced Pluripotent Stem Cells</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Ethnic Groups</term><term>Haplotypes</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA</term><term>Groupes ethniques</term><term>Haplotypes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Genetics, Population</term><term>Genotype</term><term>Histocompatibility Testing</term><term>Homozygote</term><term>Humans</term><term>Stem Cell Research</term><term>Tissue Donors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Californie</term><term>Donneurs de tissus</term><term>Génotype</term><term>Génétique des populations</term><term>Homozygote</term><term>Humains</term><term>Lignée cellulaire</term><term>Recherche sur les cellules souches</term><term>Test d'histocompatibilité</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study developed a new model for evaluating an induced pluripotent stem cell (iPSC) haplobank based on demographic and immunogenetic characteristics reflecting California. Creation of a haplobank of iPSC lines homozygous for a variety of human leukocyte antigen (HLA) types, representative of different geographic populations and ethnic groups, could simplify HLA matching and provide matches for reasonable percentages of target populations and extend iPSC-derived therapies beyond the autologous setting.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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