Advances in antibiotic therapy in the critically ill
Identifieur interne : 002402 ( Main/Merge ); précédent : 002401; suivant : 002403Advances in antibiotic therapy in the critically ill
Auteurs : Jean-Louis Vincent [Belgique] ; Matteo Bassetti [Italie] ; Bruno François [France] ; George Karam [États-Unis] ; Jean Chastre [France] ; Antoni Torres [Espagne] ; Jason A. Roberts [Australie] ; Fabio S. Taccone [Belgique] ; Jordi Rello [Espagne] ; Thierry Calandra [Suisse] ; Daniel De Backer [Belgique] ; Tobias Welte [Allemagne] ; Massimo Antonelli [Italie]Source :
- Critical Care [ 1364-8535 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antibactériens.
- usage thérapeutique : Antibactériens.
- Humains, Maladie grave.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Anti-Bacterial Agents.
- chemical , therapeutic use : Anti-Bacterial Agents.
- Critical Illness, Humans.
Abstract
Infections occur frequently in critically ill patients and their management can be challenging for various reasons, including delayed diagnosis, difficulties identifying causative microorganisms, and the high prevalence of antibiotic-resistant strains. In this review, we briefly discuss the importance of early infection diagnosis, before considering in more detail some of the key issues related to antibiotic management in these patients, including controversies surrounding use of combination or monotherapy, duration of therapy, and de-escalation. Antibiotic pharmacodynamics and pharmacokinetics, notably volumes of distribution and clearance, can be altered by critical illness and can influence dosing regimens. Dosing decisions in different subgroups of patients, e.g., the obese, are also covered. We also briefly consider ventilator-associated pneumonia and the role of inhaled antibiotics. Finally, we mention antibiotics that are currently being developed and show promise for the future.
Url:
DOI: 10.1186/s13054-016-1285-6
PubMed: 27184564
PubMed Central: 4869332
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PMC:4869332Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Infections occur frequently in critically ill patients and their management can be challenging for various reasons, including delayed diagnosis, difficulties identifying causative microorganisms, and the high prevalence of antibiotic-resistant strains. In this review, we briefly discuss the importance of early infection diagnosis, before considering in more detail some of the key issues related to antibiotic management in these patients, including controversies surrounding use of combination or monotherapy, duration of therapy, and de-escalation. Antibiotic pharmacodynamics and pharmacokinetics, notably volumes of distribution and clearance, can be altered by critical illness and can influence dosing regimens. Dosing decisions in different subgroups of patients, e.g., the obese, are also covered. We also briefly consider ventilator-associated pneumonia and the role of inhaled antibiotics. Finally, we mention antibiotics that are currently being developed and show promise for the future.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferrer, R" uniqKey="Ferrer R">R Ferrer</name>
</author>
<author><name sortKey="Martin Loeches, I" uniqKey="Martin Loeches I">I Martin-Loeches</name>
</author>
<author><name sortKey="Phillips, G" uniqKey="Phillips G">G Phillips</name>
</author>
<author><name sortKey="Osborn, Tm" uniqKey="Osborn T">TM Osborn</name>
</author>
<author><name sortKey="Townsend, S" uniqKey="Townsend S">S Townsend</name>
</author>
<author><name sortKey="Dellinger, Rp" uniqKey="Dellinger R">RP Dellinger</name>
</author>
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