Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin
Identifieur interne : 001322 ( Main/Merge ); précédent : 001321; suivant : 001323Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin
Auteurs : Mary Speir [Australie] ; Adam Vogrin [Australie] ; Azadeh Seidi [Australie] ; Gilu Abraham [Australie] ; Stéphane Hunot [États-Unis, France] ; Qingqing Han [États-Unis] ; Gerald W. Dorn [États-Unis] ; Seth L. Masters [Australie] ; Richard A. Flavell [États-Unis] ; James E. Vince [Australie] ; Thomas Naderer [Australie]Source :
- Frontiers in Cellular and Infection Microbiology [ 2235-2988 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Apoptose, Délétion de gène, Facteurs de virulence (génétique), Femelle, Flagelline (génétique), Flagelline (métabolisme), Interactions hôte-pathogène, Legionella pneumophila (physiologie), Macrophages (microbiologie), Macrophages (métabolisme), Maladie des légionnaires (microbiologie), Maladie des légionnaires (métabolisme), Mitochondries (génétique), Mitochondries (métabolisme), Mort cellulaire, Protéines bactériennes (génétique), Protéines bactériennes (métabolisme), Protéines membranaires (métabolisme), Protéines mitochondriales (métabolisme), Protéines régulatrices de l'apoptose (métabolisme), Souris, Survie cellulaire.
- MESH :
- génétique : Facteurs de virulence, Flagelline, Mitochondries, Protéines bactériennes.
- microbiologie : Macrophages, Maladie des légionnaires.
- métabolisme : Flagelline, Macrophages, Maladie des légionnaires, Mitochondries, Protéines bactériennes, Protéines membranaires, Protéines mitochondriales, Protéines régulatrices de l'apoptose.
- physiologie : Legionella pneumophila.
- Animaux, Apoptose, Délétion de gène, Femelle, Interactions hôte-pathogène, Mort cellulaire, Souris, Survie cellulaire.
English descriptors
- KwdEn :
- Animals, Apoptosis, Apoptosis Regulatory Proteins (metabolism), Bacterial Proteins (genetics), Bacterial Proteins (metabolism), Cell Death, Cell Survival, Female, Flagellin (genetics), Flagellin (metabolism), Gene Deletion, Host-Pathogen Interactions, Legionella pneumophila (physiology), Legionnaires' Disease (metabolism), Legionnaires' Disease (microbiology), Macrophages (metabolism), Macrophages (microbiology), Membrane Proteins (metabolism), Mice, Mitochondria (genetics), Mitochondria (metabolism), Mitochondrial Proteins (metabolism), Virulence Factors (genetics).
- MESH :
- chemical , genetics : Bacterial Proteins, Flagellin, Virulence Factors.
- chemical , metabolism : Apoptosis Regulatory Proteins, Bacterial Proteins, Flagellin, Membrane Proteins, Mitochondrial Proteins.
- genetics : Mitochondria.
- metabolism : Legionnaires' Disease, Macrophages, Mitochondria.
- microbiology : Legionnaires' Disease, Macrophages.
- physiology : Legionella pneumophila.
- Animals, Apoptosis, Cell Death, Cell Survival, Female, Gene Deletion, Host-Pathogen Interactions, Mice.
Abstract
The human pathogen
Url:
DOI: 10.3389/fcimb.2017.00035
PubMed: 28261564
PubMed Central: 5311068
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last="Vogrin">Adam Vogrin</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University</institution><country>Clayton, VIC, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Seidi, Azadeh" sort="Seidi, Azadeh" uniqKey="Seidi A" first="Azadeh" last="Seidi">Azadeh Seidi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University</institution><country>Clayton, VIC, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Abraham, Gilu" sort="Abraham, Gilu" uniqKey="Abraham G" first="Gilu" last="Abraham">Gilu Abraham</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University</institution><country>Clayton, VIC, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stéphane" last="Hunot">Stéphane Hunot</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine</institution><country>New Haven, CT, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Institut du Cerveau et la Moelle - Hôpital Pitié-Salpêtrière, Boulevard de l'hôpital, Sorbonne Universités, UPMC Univ Paris 06</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Han, Qingqing" sort="Han, Qingqing" uniqKey="Han Q" first="Qingqing" last="Han">Qingqing Han</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine</institution><country>New Haven, CT, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Dorn, Gerald W" sort="Dorn, Gerald W" uniqKey="Dorn G" first="Gerald W." last="Dorn">Gerald W. Dorn</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Medicine, Center for Pharmacogenomics, Washington University School of Medicine</institution><country>St. Louis, MO, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Masters, Seth L" sort="Masters, Seth L" uniqKey="Masters S" first="Seth L." last="Masters">Seth L. Masters</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Walter and Eliza Hall Institute of Medical Research</institution><country>Parkville, VIC, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Medical Biology, University of Melbourne</institution><country>Parkville, VIC, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Flavell, Richard A" sort="Flavell, Richard A" uniqKey="Flavell R" first="Richard A." last="Flavell">Richard A. Flavell</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine</institution><country>New Haven, CT, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Vince, James E" sort="Vince, James E" uniqKey="Vince J" first="James E." last="Vince">James E. Vince</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Walter and Eliza Hall Institute of Medical Research</institution><country>Parkville, VIC, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Medical Biology, University of Melbourne</institution><country>Parkville, VIC, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Naderer, Thomas" sort="Naderer, Thomas" 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(genetics)</term><term>Bacterial Proteins (metabolism)</term><term>Cell Death</term><term>Cell Survival</term><term>Female</term><term>Flagellin (genetics)</term><term>Flagellin (metabolism)</term><term>Gene Deletion</term><term>Host-Pathogen Interactions</term><term>Legionella pneumophila (physiology)</term><term>Legionnaires' Disease (metabolism)</term><term>Legionnaires' Disease (microbiology)</term><term>Macrophages (metabolism)</term><term>Macrophages (microbiology)</term><term>Membrane Proteins (metabolism)</term><term>Mice</term><term>Mitochondria (genetics)</term><term>Mitochondria (metabolism)</term><term>Mitochondrial Proteins (metabolism)</term><term>Virulence Factors (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Délétion de gène</term><term>Facteurs de virulence (génétique)</term><term>Femelle</term><term>Flagelline (génétique)</term><term>Flagelline (métabolisme)</term><term>Interactions hôte-pathogène</term><term>Legionella pneumophila (physiologie)</term><term>Macrophages (microbiologie)</term><term>Macrophages (métabolisme)</term><term>Maladie des légionnaires (microbiologie)</term><term>Maladie des légionnaires (métabolisme)</term><term>Mitochondries (génétique)</term><term>Mitochondries (métabolisme)</term><term>Mort cellulaire</term><term>Protéines bactériennes (génétique)</term><term>Protéines bactériennes (métabolisme)</term><term>Protéines membranaires (métabolisme)</term><term>Protéines mitochondriales (métabolisme)</term><term>Protéines régulatrices de l'apoptose (métabolisme)</term><term>Souris</term><term>Survie cellulaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term><term>Flagellin</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Apoptosis Regulatory Proteins</term><term>Bacterial Proteins</term><term>Flagellin</term><term>Membrane Proteins</term><term>Mitochondrial Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de virulence</term><term>Flagelline</term><term>Mitochondries</term><term>Protéines bactériennes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Legionnaires' Disease</term><term>Macrophages</term><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Macrophages</term><term>Maladie des légionnaires</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Legionnaires' Disease</term><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Flagelline</term><term>Macrophages</term><term>Maladie des légionnaires</term><term>Mitochondries</term><term>Protéines bactériennes</term><term>Protéines membranaires</term><term>Protéines mitochondriales</term><term>Protéines régulatrices de l'apoptose</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Legionella pneumophila</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Legionella pneumophila</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Cell Death</term><term>Cell Survival</term><term>Female</term><term>Gene Deletion</term><term>Host-Pathogen Interactions</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Délétion de gène</term><term>Femelle</term><term>Interactions hôte-pathogène</term><term>Mort cellulaire</term><term>Souris</term><term>Survie cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The human pathogen <italic>Legionella pneumophila</italic> must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, <italic>L. pneumophila</italic> is thought to induce apoptosis during egress from macrophages. The bacterial effector protein, SidF, has been shown to control host cell survival and death by inhibiting pro-apoptotic BNIP3 and BCL-RAMBO signaling. Using live-cell imaging to follow the <italic>L. pneumophila</italic>-macrophage interaction, we now demonstrate that <italic>L. pneumophila</italic> evades host cell apoptosis independent of SidF. In the absence of SidF, <italic>L. pneumophila</italic> was able to replicate, cause loss of mitochondria membrane potential, kill macrophages, and establish infections in lungs of mice. Consistent with this, deletion of BNIP3 and BCL-RAMBO did not affect intracellular <italic>L. pneumophila</italic> replication, macrophage death rates, and <italic>in vivo</italic> bacterial virulence. Abrogating mitochondrial cell death by genetic deletion of the effectors of intrinsic apoptosis, BAX, and BAK, or the regulator of mitochondrial permeability transition pore formation, cyclophilin-D, did not affect bacterial growth or the initial killing of macrophages. Loss of BAX and BAK only marginally limited the ability of <italic>L. pneumophila</italic> to efficiently kill all macrophages over extended periods. <italic>L. pneumophila</italic> induced killing of macrophages was delayed in the absence of capsase-11 mediated pyroptosis. Together, our data demonstrate that <italic>L. pneumophila</italic> evades host cell death responses independently of SidF during replication and can induce pyroptosis to kill macrophages in a timely manner.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abu Zant, A" uniqKey="Abu Zant A">A. Abu-Zant</name></author><author><name sortKey="Jones, S" uniqKey="Jones S">S. 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