Inclusion of Digestible Surfactants in Solid SMEDDS Formulation Removes Lag Time and Influences the Formation of Structured Particles During Digestion.
Identifieur interne : 000993 ( Main/Merge ); précédent : 000992; suivant : 000994Inclusion of Digestible Surfactants in Solid SMEDDS Formulation Removes Lag Time and Influences the Formation of Structured Particles During Digestion.
Auteurs : Kapilkumar Vithani [Australie] ; Adrian Hawley [Australie] ; Vincent Jannin [France] ; Colin Pouton [Australie] ; Ben J. Boyd [Australie]Source :
- The AAPS journal [ 1550-7416 ] ; 2017.
Abstract
Solid self-microemulsifying drug delivery systems (SMEDDS) have received considerable attention in recent times attempting to overcome the drawbacks of liquid SMEDDS. Earlier literature reports on solid SMEDDS have focussed on formulation development; however, the digestibility and propensity for self-assembly of the digested components with endogenous bile salts and phospholipids are unknown. Therefore, as a starting point, previously reported solid SMEDDS containing Gelucire® 44/14 (GEL) and the non-digestible surfactants, Vitamin E TPGS (TPGS) and Lutrol® F 127 (F 127), were prepared, and their dispersion and digestion behaviours were studied using an in vitro lipolysis model, coupled with small-angle X-ray scattering (SAXS) to determine the formed colloidal structures during digestion in real time. GEL alone was digested (89%) and formed a lamellar phase (Lα). When surfactants were added at a 40:60% w/w lipid to surfactants ratio, digestion was inhibited with a significant lag time being evident. However, increasing the fraction of GEL to 50% w/w enabled digestion with reduced lag time. The substitution of the non-digestible surfactants with digestible surfactants, sucrose esters S-1670 (S-1670) and Span® 60 (S-60), eliminated the digestion lag time, and the formation of colloidal structures was more similar to that of GEL alone.
DOI: 10.1208/s12248-016-0036-6
PubMed: 28116678
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000D29
- to stream PubMed, to step Curation: 000D26
- to stream PubMed, to step Checkpoint: 000D26
- to stream Ncbi, to step Merge: 004210
- to stream Ncbi, to step Curation: 004210
- to stream Ncbi, to step Checkpoint: 004210
Links to Exploration step
pubmed:28116678Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inclusion of Digestible Surfactants in Solid SMEDDS Formulation Removes Lag Time and Influences the Formation of Structured Particles During Digestion.</title><author><name sortKey="Vithani, Kapilkumar" sort="Vithani, Kapilkumar" uniqKey="Vithani K" first="Kapilkumar" last="Vithani">Kapilkumar Vithani</name><affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Hawley, Adrian" sort="Hawley, Adrian" uniqKey="Hawley A" first="Adrian" last="Hawley">Adrian Hawley</name><affiliation wicri:level="1"><nlm:affiliation>SAXS/WAXS Beamtime, Australian Synchrotron, Clayton, Victoria, 3168, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>SAXS/WAXS Beamtime, Australian Synchrotron, Clayton, Victoria, 3168</wicri:regionArea><wicri:noRegion>3168</wicri:noRegion></affiliation></author><author><name sortKey="Jannin, Vincent" sort="Jannin, Vincent" uniqKey="Jannin V" first="Vincent" last="Jannin">Vincent Jannin</name><affiliation wicri:level="1"><nlm:affiliation>Gattefossé SAS, 36 Chemin de Genas, 69804, Saint-Priest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gattefossé SAS, 36 Chemin de Genas, 69804, Saint-Priest</wicri:regionArea><wicri:noRegion>69804, Saint-Priest</wicri:noRegion><wicri:noRegion>69804, Saint-Priest</wicri:noRegion></affiliation></author><author><name sortKey="Pouton, Colin" sort="Pouton, Colin" uniqKey="Pouton C" first="Colin" last="Pouton">Colin Pouton</name><affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Boyd, Ben J" sort="Boyd, Ben J" uniqKey="Boyd B" first="Ben J" last="Boyd">Ben J. Boyd</name><affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052, Australia. ben.boyd@monash.edu.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28116678</idno><idno type="pmid">28116678</idno><idno type="doi">10.1208/s12248-016-0036-6</idno><idno type="wicri:Area/PubMed/Corpus">000D29</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D29</idno><idno type="wicri:Area/PubMed/Curation">000D26</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D26</idno><idno type="wicri:Area/PubMed/Checkpoint">000D26</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D26</idno><idno type="wicri:Area/Ncbi/Merge">004210</idno><idno type="wicri:Area/Ncbi/Curation">004210</idno><idno type="wicri:Area/Ncbi/Checkpoint">004210</idno><idno type="wicri:Area/Main/Merge">000993</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inclusion of Digestible Surfactants in Solid SMEDDS Formulation Removes Lag Time and Influences the Formation of Structured Particles During Digestion.</title><author><name sortKey="Vithani, Kapilkumar" sort="Vithani, Kapilkumar" uniqKey="Vithani K" first="Kapilkumar" last="Vithani">Kapilkumar Vithani</name><affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Hawley, Adrian" sort="Hawley, Adrian" uniqKey="Hawley A" first="Adrian" last="Hawley">Adrian Hawley</name><affiliation wicri:level="1"><nlm:affiliation>SAXS/WAXS Beamtime, Australian Synchrotron, Clayton, Victoria, 3168, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>SAXS/WAXS Beamtime, Australian Synchrotron, Clayton, Victoria, 3168</wicri:regionArea><wicri:noRegion>3168</wicri:noRegion></affiliation></author><author><name sortKey="Jannin, Vincent" sort="Jannin, Vincent" uniqKey="Jannin V" first="Vincent" last="Jannin">Vincent Jannin</name><affiliation wicri:level="1"><nlm:affiliation>Gattefossé SAS, 36 Chemin de Genas, 69804, Saint-Priest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gattefossé SAS, 36 Chemin de Genas, 69804, Saint-Priest</wicri:regionArea><wicri:noRegion>69804, Saint-Priest</wicri:noRegion><wicri:noRegion>69804, Saint-Priest</wicri:noRegion></affiliation></author><author><name sortKey="Pouton, Colin" sort="Pouton, Colin" uniqKey="Pouton C" first="Colin" last="Pouton">Colin Pouton</name><affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Boyd, Ben J" sort="Boyd, Ben J" uniqKey="Boyd B" first="Ben J" last="Boyd">Ben J. Boyd</name><affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052, Australia. ben.boyd@monash.edu.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author></analytic><series><title level="j">The AAPS journal</title><idno type="eISSN">1550-7416</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Solid self-microemulsifying drug delivery systems (SMEDDS) have received considerable attention in recent times attempting to overcome the drawbacks of liquid SMEDDS. Earlier literature reports on solid SMEDDS have focussed on formulation development; however, the digestibility and propensity for self-assembly of the digested components with endogenous bile salts and phospholipids are unknown. Therefore, as a starting point, previously reported solid SMEDDS containing Gelucire® 44/14 (GEL) and the non-digestible surfactants, Vitamin E TPGS (TPGS) and Lutrol® F 127 (F 127), were prepared, and their dispersion and digestion behaviours were studied using an in vitro lipolysis model, coupled with small-angle X-ray scattering (SAXS) to determine the formed colloidal structures during digestion in real time. GEL alone was digested (89%) and formed a lamellar phase (Lα). When surfactants were added at a 40:60% w/w lipid to surfactants ratio, digestion was inhibited with a significant lag time being evident. However, increasing the fraction of GEL to 50% w/w enabled digestion with reduced lag time. The substitution of the non-digestible surfactants with digestible surfactants, sucrose esters S-1670 (S-1670) and Span® 60 (S-60), eliminated the digestion lag time, and the formation of colloidal structures was more similar to that of GEL alone.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000993 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000993 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Merge
|type= RBID
|clé= pubmed:28116678
|texte= Inclusion of Digestible Surfactants in Solid SMEDDS Formulation Removes Lag Time and Influences the Formation of Structured Particles During Digestion.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:28116678" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |