Caveolin-1-dependent and -independent membrane domains[S]
Identifieur interne : 007C46 ( Main/Exploration ); précédent : 007C45; suivant : 007C47Caveolin-1-dependent and -independent membrane domains[S]
Auteurs : Soazig Le Lay [France] ; Qiong Li [Australie] ; Nicholas Proschogo [Australie] ; Macarena Rodriguez [Australie] ; Krishanthi Gunaratnam [Australie] ; Siân Cartland [Australie] ; Carles Rentero [Australie] ; Wendy Jessup [Australie] ; Todd Mitchell [Australie] ; Katharina Gaus [Australie]Source :
- Journal of Lipid Research [ 0022-2275 ] ; 2009.
Abstract
Lipid rafts defined as cholesterol- and sphingomyelin-rich domains have been isolated from different cell types that vary greatly in their lipid profiles. Here, we investigated the contribution of the structural protein caveolin-1 (Cav1) to the overall lipid composition and domain abundance in mouse embryonic fibroblasts (MEFs) from wild-type (WT) or Cav1-deficient (Cav1−/−) animals. Our findings show that Cav1 expression had no effect on free (membrane-associated) cholesterol levels. However, Cav1−/−-deficient cells did have a higher proportion of sphingomyelin, decreased abundance of unsaturated phospholipids, and a trend toward shorter fatty acid chains in phosphatidylcholine. We isolated detergent-resistant membranes (DRMs), nondetergent raft domains (NDR), and cholesterol oxidase (CO)-sensitive domains and assessed the abundance of ordered domains in intact cells using the fluorescent dye Laurdan. Despite differences in phospholipid composition, we found that cholesterol levels in DRMs, NDR, and CO-sensitive domains were similar in both cell types. The data suggest that Cav1 is not required to target cholesterol to lipid rafts and that CO does not specifically oxidize caveolar cholesterol. In contrast, the abundance of ordered domains in adherent cells is reduced in Cav1−/− compared with WT MEFs, suggesting that cell architecture is critical in maintaining Cav1-induced lipid rafts.
Url:
DOI: 10.1194/jlr.M800601-JLR200
PubMed: 19074371
PubMed Central: 2724060
Affiliations:
- Australie, France
- Nouvelle-Galles du Sud, Île-de-France
- Paris, Sydney
- Université Paris-Descartes, Université Pierre-et-Marie-Curie
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Lipid rafts defined as cholesterol- and sphingomyelin-rich domains have been isolated from different cell types that vary greatly in their lipid profiles. Here, we investigated the contribution of the structural protein caveolin-1 (Cav1) to the overall lipid composition and domain abundance in mouse embryonic fibroblasts (MEFs) from wild-type (WT) or Cav1-deficient (Cav1<sup>−/−</sup>
) animals. Our findings show that Cav1 expression had no effect on free (membrane-associated) cholesterol levels. However, Cav1<sup>−/−</sup>
-deficient cells did have a higher proportion of sphingomyelin, decreased abundance of unsaturated phospholipids, and a trend toward shorter fatty acid chains in phosphatidylcholine. We isolated detergent-resistant membranes (DRMs), nondetergent raft domains (NDR), and cholesterol oxidase (CO)-sensitive domains and assessed the abundance of ordered domains in intact cells using the fluorescent dye Laurdan. Despite differences in phospholipid composition, we found that cholesterol levels in DRMs, NDR, and CO-sensitive domains were similar in both cell types. The data suggest that Cav1 is not required to target cholesterol to lipid rafts and that CO does not specifically oxidize caveolar cholesterol. In contrast, the abundance of ordered domains in adherent cells is reduced in Cav1<sup>−/−</sup>
compared with WT MEFs, suggesting that cell architecture is critical in maintaining Cav1-induced lipid rafts.</p>
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<author><name sortKey="Schmitz, G" uniqKey="Schmitz G">G. Schmitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Masserini, M" uniqKey="Masserini M">M. Masserini</name>
</author>
<author><name sortKey="Ravasi, D" uniqKey="Ravasi D">D. Ravasi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rouquette Jazdanian, A K" uniqKey="Rouquette Jazdanian A">A. K. Rouquette-Jazdanian</name>
</author>
<author><name sortKey="Pelassy, C" uniqKey="Pelassy C">C. Pelassy</name>
</author>
<author><name sortKey="Breittmayer, J P" uniqKey="Breittmayer J">J. P. Breittmayer</name>
</author>
<author><name sortKey="Aussel, C" uniqKey="Aussel C">C. Aussel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Slotte, J P" uniqKey="Slotte J">J. P. Slotte</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ahn, K W" uniqKey="Ahn K">K. W. Ahn</name>
</author>
<author><name sortKey="Sampson, N S" uniqKey="Sampson N">N. S. Sampson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cahuzac, N" uniqKey="Cahuzac N">N. Cahuzac</name>
</author>
<author><name sortKey="Baum, W" uniqKey="Baum W">W. Baum</name>
</author>
<author><name sortKey="Kirkin, V" uniqKey="Kirkin V">V. Kirkin</name>
</author>
<author><name sortKey="Conchonaud, F" uniqKey="Conchonaud F">F. Conchonaud</name>
</author>
<author><name sortKey="Wawrezinieck, L" uniqKey="Wawrezinieck L">L. Wawrezinieck</name>
</author>
<author><name sortKey="Marguet, D" uniqKey="Marguet D">D. Marguet</name>
</author>
<author><name sortKey="Janssen, O" uniqKey="Janssen O">O. Janssen</name>
</author>
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</author>
<author><name sortKey="Hueber, A O" uniqKey="Hueber A">A. O. Hueber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okamoto, Y" uniqKey="Okamoto Y">Y. Okamoto</name>
</author>
<author><name sortKey="Ninomiya, H" uniqKey="Ninomiya H">H. Ninomiya</name>
</author>
<author><name sortKey="Miwa, S" uniqKey="Miwa S">S. Miwa</name>
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<author><name sortKey="Masaki, T" uniqKey="Masaki T">T. Masaki</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Maclachlan, J" uniqKey="Maclachlan J">J. MacLachlan</name>
</author>
<author><name sortKey="Wotherspoon, A T" uniqKey="Wotherspoon A">A. T. Wotherspoon</name>
</author>
<author><name sortKey="Ansell, R O" uniqKey="Ansell R">R. O. Ansell</name>
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<author><name sortKey="Brooks, C J" uniqKey="Brooks C">C. J. Brooks</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
<li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université Paris-Descartes</li>
<li>Université Pierre-et-Marie-Curie</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Le Lay, Soazig" sort="Le Lay, Soazig" uniqKey="Le Lay S" first="Soazig" last="Le Lay">Soazig Le Lay</name>
</region>
<name sortKey="Le Lay, Soazig" sort="Le Lay, Soazig" uniqKey="Le Lay S" first="Soazig" last="Le Lay">Soazig Le Lay</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Li, Qiong" sort="Li, Qiong" uniqKey="Li Q" first="Qiong" last="Li">Qiong Li</name>
</region>
<name sortKey="Cartland, Sian" sort="Cartland, Sian" uniqKey="Cartland S" first="Siân" last="Cartland">Siân Cartland</name>
<name sortKey="Gaus, Katharina" sort="Gaus, Katharina" uniqKey="Gaus K" first="Katharina" last="Gaus">Katharina Gaus</name>
<name sortKey="Gunaratnam, Krishanthi" sort="Gunaratnam, Krishanthi" uniqKey="Gunaratnam K" first="Krishanthi" last="Gunaratnam">Krishanthi Gunaratnam</name>
<name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name>
<name sortKey="Mitchell, Todd" sort="Mitchell, Todd" uniqKey="Mitchell T" first="Todd" last="Mitchell">Todd Mitchell</name>
<name sortKey="Mitchell, Todd" sort="Mitchell, Todd" uniqKey="Mitchell T" first="Todd" last="Mitchell">Todd Mitchell</name>
<name sortKey="Proschogo, Nicholas" sort="Proschogo, Nicholas" uniqKey="Proschogo N" first="Nicholas" last="Proschogo">Nicholas Proschogo</name>
<name sortKey="Rentero, Carles" sort="Rentero, Carles" uniqKey="Rentero C" first="Carles" last="Rentero">Carles Rentero</name>
<name sortKey="Rodriguez, Macarena" sort="Rodriguez, Macarena" uniqKey="Rodriguez M" first="Macarena" last="Rodriguez">Macarena Rodriguez</name>
</country>
</tree>
</affiliations>
</record>
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