CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche
Identifieur interne : 007C47 ( Main/Curation ); précédent : 007C46; suivant : 007C48CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche
Auteurs : Stéphane Chevrier [Suisse] ; Céline Genton [Suisse] ; Axel Kallies [Australie] ; Alexander Karnowski [Australie] ; Luc A. Otten [Suisse] ; Bernard Malissen [France] ; Marie Malissen [France] ; Marina Botto [Royaume-Uni] ; Lynn M. Corcoran [Australie] ; Stephen L. Nutt [Australie] ; Hans Acha-Orbea [Suisse]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2009.
Abstract
Plasma cells represent the end stage of B-cell development and play a key role in providing an efficient antibody response, but they are also involved in numerous pathologies. Here we show that CD93, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. T-independent and T-dependent stimuli led to re-expression of CD93 via 2 pathways, either before or after CD138 or Blimp-1 expression. Strikingly, while humoral immune responses initially proceeded normally, CD93-deficient mice were unable to maintain antibody secretion and bone-marrow plasma-cell numbers, demonstrating that CD93 is important for the maintenance of plasma cells in bone marrow niches.
Url:
DOI: 10.1073/pnas.0809736106
PubMed: 19228948
PubMed Central: 2656176
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Otten</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges</wicri:regionArea><wicri:noRegion>1066 Epalinges</wicri:noRegion></affiliation></author><author><name sortKey="Malissen, Bernard" sort="Malissen, Bernard" uniqKey="Malissen B" first="Bernard" last="Malissen">Bernard Malissen</name><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale/Centre National de la Recherche Scientifique, Université de la Méditerranée, 13284 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale/Centre National de la Recherche Scientifique, Université de la Méditerranée, 13284 Marseille</wicri:regionArea><wicri:noRegion>13284 Marseille</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université de la Méditerranée</orgName></affiliation></author><author><name sortKey="Malissen, Marie" sort="Malissen, Marie" uniqKey="Malissen M" first="Marie" last="Malissen">Marie Malissen</name><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale/Centre National de la Recherche Scientifique, Université de la Méditerranée, 13284 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale/Centre National de la Recherche Scientifique, Université de la Méditerranée, 13284 Marseille</wicri:regionArea><wicri:noRegion>13284 Marseille</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université de la Méditerranée</orgName></affiliation></author><author><name sortKey="Botto, Marina" sort="Botto, Marina" uniqKey="Botto M" first="Marina" last="Botto">Marina Botto</name><affiliation wicri:level="1"><nlm:aff id="aff4">Molecular Genetics and Rheumatology Section, Division of Medicine, Faculty of Medicine, Imperial College, Hammersmith Campus, London W12 0NN, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular Genetics and Rheumatology Section, Division of Medicine, Faculty of Medicine, Imperial College, Hammersmith Campus, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation></author><author><name sortKey="Corcoran, Lynn M" sort="Corcoran, Lynn M" uniqKey="Corcoran L" first="Lynn M." last="Corcoran">Lynn M. Corcoran</name><affiliation wicri:level="1"><nlm:aff id="aff2">The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050</wicri:regionArea><wicri:noRegion>Victoria 3050</wicri:noRegion></affiliation></author><author><name sortKey="Nutt, Stephen L" sort="Nutt, Stephen L" uniqKey="Nutt S" first="Stephen L." last="Nutt">Stephen L. Nutt</name><affiliation wicri:level="1"><nlm:aff id="aff2">The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050</wicri:regionArea><wicri:noRegion>Victoria 3050</wicri:noRegion></affiliation></author><author><name sortKey="Acha Orbea, Hans" sort="Acha Orbea, Hans" uniqKey="Acha Orbea H" first="Hans" last="Acha-Orbea">Hans Acha-Orbea</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges</wicri:regionArea><wicri:noRegion>1066 Epalinges</wicri:noRegion></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Plasma cells represent the end stage of B-cell development and play a key role in providing an efficient antibody response, but they are also involved in numerous pathologies. Here we show that CD93, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. T-independent and T-dependent stimuli led to re-expression of CD93 via 2 pathways, either before or after CD138 or Blimp-1 expression. Strikingly, while humoral immune responses initially proceeded normally, CD93-deficient mice were unable to maintain antibody secretion and bone-marrow plasma-cell numbers, demonstrating that CD93 is important for the maintenance of plasma cells in bone marrow niches.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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