CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche
Identifieur interne : 007C47 ( Main/Curation ); précédent : 007C46; suivant : 007C48CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche
Auteurs : Stéphane Chevrier [Suisse] ; Céline Genton [Suisse] ; Axel Kallies [Australie] ; Alexander Karnowski [Australie] ; Luc A. Otten [Suisse] ; Bernard Malissen [France] ; Marie Malissen [France] ; Marina Botto [Royaume-Uni] ; Lynn M. Corcoran [Australie] ; Stephen L. Nutt [Australie] ; Hans Acha-Orbea [Suisse]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2009.
Abstract
Plasma cells represent the end stage of B-cell development and play a key role in providing an efficient antibody response, but they are also involved in numerous pathologies. Here we show that CD93, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. T-independent and T-dependent stimuli led to re-expression of CD93 via 2 pathways, either before or after CD138 or Blimp-1 expression. Strikingly, while humoral immune responses initially proceeded normally, CD93-deficient mice were unable to maintain antibody secretion and bone-marrow plasma-cell numbers, demonstrating that CD93 is important for the maintenance of plasma cells in bone marrow niches.
Url:
DOI: 10.1073/pnas.0809736106
PubMed: 19228948
PubMed Central: 2656176
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PMC:2656176Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Plasma cells represent the end stage of B-cell development and play a key role in providing an efficient antibody response, but they are also involved in numerous pathologies. Here we show that CD93, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. T-independent and T-dependent stimuli led to re-expression of CD93 via 2 pathways, either before or after CD138 or Blimp-1 expression. Strikingly, while humoral immune responses initially proceeded normally, CD93-deficient mice were unable to maintain antibody secretion and bone-marrow plasma-cell numbers, demonstrating that CD93 is important for the maintenance of plasma cells in bone marrow niches.</p>
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