2R or not 2R?
Identifieur interne : 000182 ( Main/Corpus ); précédent : 000181; suivant : 0001832R or not 2R?
Auteurs : John S. Taylor ; Henner BrinkmannSource :
- Trends in Genetics [ 0168-9525 ] ; 2001.
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DOI: 10.1016/S0168-9525(01)02411-8
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Taylor</name><affiliation><mods:affiliation>Dept of Biology, University of Konstanz, 78457 Konstanz, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: john.taylor@uni-konstanz.de</mods:affiliation></affiliation></author><author><name sortKey="Brinkmann, Henner" sort="Brinkmann, Henner" uniqKey="Brinkmann H" first="Henner" last="Brinkmann">Henner Brinkmann</name><affiliation><mods:affiliation>Dept of Biology, University of Konstanz, 78457 Konstanz, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3B69CE4D2E3D64A576925370C573B8F26337C624</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1016/S0168-9525(01)02411-8</idno><idno type="url">https://api.istex.fr/document/3B69CE4D2E3D64A576925370C573B8F26337C624/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000182</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="ISTEX">000182</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">2R or not 2R?</title><author><name sortKey="Taylor, John S" sort="Taylor, John S" uniqKey="Taylor J" first="John S" last="Taylor">John S. Taylor</name><affiliation><mods:affiliation>Dept of Biology, University of Konstanz, 78457 Konstanz, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: john.taylor@uni-konstanz.de</mods:affiliation></affiliation></author><author><name sortKey="Brinkmann, Henner" sort="Brinkmann, Henner" uniqKey="Brinkmann H" first="Henner" last="Brinkmann">Henner Brinkmann</name><affiliation><mods:affiliation>Dept of Biology, University of Konstanz, 78457 Konstanz, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Trends in Genetics</title><title level="j" type="abbrev">TIGS</title><idno type="ISSN">0168-9525</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="488">488</biblScope><biblScope unit="page" to="489">489</biblScope></imprint><idno 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2R?</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>2001</date></publicationStmt><notesStmt><note type="content">Section title: Research update</note><note type="content">Fig. 1: Two possible phylogenies of gene families with four members (A–D) in vertebrates. (a) The symmetrical (AB)(CD) topology predicted by the 2R hypothesis (see text). T1 is the time of the first genome duplication event and T2 is the time of the second genome duplication. (b) Short internal branches and/or evolutionary rate variation among paralogues can lead to the erroneous reconstruction of an asymmetrical A(B(CD)) tree.</note><note type="content">Fig. 2: An 11.5-day-old embryonic transgenic mouse carrying a small heat shock protein/alphaB-crystallin enhancer driving the lacZ reporter gene (adapted, with permission, from Ref. 13). An ancestral small heat shock protein/alpha-crystallin duplicated at least 500 million years ago producing alphaA-crystallin and alphaB-crystallin. The figure shows that the alphaB-crystallin promoter is active in many developing tissues including the somites, heart and eye. In adults, alphaB-crystallin is expressed constitutively, especially in the lens, heart and skeletal muscles, and is stress inducible. By contrast, alphaA-crystallin is almost lens-specific and is not stress inducible. In Aussois, Joram Piatigorsky (NIH, Bethesda, MD, USA) reported that for these, and other porteins 14, the evolution of novel gene functions (e.g. lens proteins) precedes gene duplication. Selection could favour the retention of duplicates if one copy specilizes on a subset of the ancestral roles as appears to have occurred with alphaA-crystallin in mouse.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">2R or not 2R?</title><author><persName><forename type="first">John S</forename><surname>Taylor</surname></persName><email>john.taylor@uni-konstanz.de</email><affiliation>Dept of Biology, University of Konstanz, 78457 Konstanz, Germany</affiliation></author><author><persName><forename type="first">Henner</forename><surname>Brinkmann</surname></persName><affiliation>Dept of Biology, University of Konstanz, 78457 Konstanz, Germany</affiliation></author></analytic><monogr><title level="j">Trends in Genetics</title><title level="j" type="abbrev">TIGS</title><idno type="pISSN">0168-9525</idno><idno type="PII">S0168-9525(00)X0079-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001"></date><biblScope unit="volume">17</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="488">488</biblScope><biblScope unit="page" to="489">489</biblScope></imprint></monogr><idno type="istex">3B69CE4D2E3D64A576925370C573B8F26337C624</idno><idno type="DOI">10.1016/S0168-9525(01)02411-8</idno><idno type="PII">S0168-9525(01)02411-8</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><textClass><keywords scheme="keyword"><list><head>Article category</head><item><term>Meeting report</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>genome duplication</term></item><item><term>2R hypothesis</term></item><item><term>gene copy number</term></item><item><term>Ho gen cluster</term></item><item><term>tandem duplication</term></item><item><term>phyligenetic tree</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Evolution</term></item><item><term>Genetics</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3B69CE4D2E3D64A576925370C573B8F26337C624/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; 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(a) The symmetrical (AB)(CD) topology predicted by the 2R hypothesis (see text). T1 is the time of the first genome duplication event and T2 is the time of the second genome duplication. (b) Short internal branches and/or evolutionary rate variation among paralogues can lead to the erroneous reconstruction of an asymmetrical A(B(CD)) tree.</note><note type="content">Fig. 2: An 11.5-day-old embryonic transgenic mouse carrying a small heat shock protein/alphaB-crystallin enhancer driving the lacZ reporter gene (adapted, with permission, from Ref. 13). An ancestral small heat shock protein/alpha-crystallin duplicated at least 500 million years ago producing alphaA-crystallin and alphaB-crystallin. The figure shows that the alphaB-crystallin promoter is active in many developing tissues including the somites, heart and eye. In adults, alphaB-crystallin is expressed constitutively, especially in the lens, heart and skeletal muscles, and is stress inducible. By contrast, alphaA-crystallin is almost lens-specific and is not stress inducible. In Aussois, Joram Piatigorsky (NIH, Bethesda, MD, USA) reported that for these, and other porteins 14, the evolution of novel gene functions (e.g. lens proteins) precedes gene duplication. Selection could favour the retention of duplicates if one copy specilizes on a subset of the ancestral roles as appears to have occurred with alphaA-crystallin in mouse.</note><subject><genre>article-category</genre><topic>Meeting report</topic></subject><subject lang="en"><genre>Keywords</genre><topic>genome duplication</topic><topic>2R hypothesis</topic><topic>gene copy number</topic><topic>Ho gen cluster</topic><topic>tandem duplication</topic><topic>phyligenetic tree</topic></subject><subject lang="en"><genre>Keywords</genre><topic>Evolution</topic><topic>Genetics</topic></subject><relatedItem type="host"><titleInfo><title>Trends in Genetics</title></titleInfo><titleInfo type="abbreviated"><title>TIGS</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">20010901</dateIssued></originInfo><identifier type="ISSN">0168-9525</identifier><identifier type="PII">S0168-9525(00)X0079-0</identifier><part><date>20010901</date><detail type="volume"><number>17</number><caption>vol.</caption></detail><detail type="issue"><number>9</number><caption>no.</caption></detail><extent unit="issue pages"><start>481</start><end>547</end></extent><extent unit="pages"><start>488</start><end>489</end></extent></part></relatedItem><identifier type="istex">3B69CE4D2E3D64A576925370C573B8F26337C624</identifier><identifier type="DOI">10.1016/S0168-9525(01)02411-8</identifier><identifier type="PII">S0168-9525(01)02411-8</identifier><accessCondition type="use and reproduction" contentType="">© 2001Elsevier Science Ltd</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science Ltd, ©2001</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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