001600 Diversity, role in decomposition, and succession of zoosporic fungi and straminipiles on submerged decaying leaves in a woodland streamA. V. MaranoInstituto de Botánica Spegazzini, Universidad Nacional de La Plata, calle 53 N 477La Plata, Buenos Aires 1900ARG1 aut.4 aut.C. L. A. Pires-ZottarelliInstituto de Botânica, CP 3005São Paulo, SP 01061-970BRA2 aut.M. D. BarreraLaboratorio de Investigación en Sistemas Ecológicos y Ambientales, Universidad Nacional de La Plata, Diagonal 113 N 469La Plata, Buenos AiresARG3 aut.M. M. SteciowInstituto de Botánica Spegazzini, Universidad Nacional de La Plata, calle 53 N 477La Plata, Buenos Aires 1900ARG1 aut.4 aut.F. H. GleasonSchool of Biological Sciences A12, University of SydneySydney, NSW 2006AUS5 aut.11-00837902011PASCAL 11-0083790 INISTPascal:11-00837900012970018-8158Hydrobiologia : (Hague)Hydrobiologia : (The Hague)Aquatic environmentDecompositionDiversityEcosystemFungiHydrobiologyPlant leafStreamWoodlandDiversitéDécompositionFeuille végétalCours eauMilieu aquatiqueEcosystèmeHydrobiologieFungiForêt claire
Leaf litter is a very important primary source of energy in woodland streams. Decomposition of leaf litter is a process mediated by many groups of microorganisms which release extracellular enzymes for the degradation of complex macromolecules. In this process, true fungi and straminipiles are considered to be among the most active groups, more active than the bacteria, at least during the early stages of the process. Colonization increases the quality of the leaves as a food resource for detritivores. In this way, matter and energy enter detritus-based food chains. Previously, aquatic hyphomycetes were considered to be the major fungal group responsible for leaf litter decomposition. Although zoosporic fungi and straminipiles are known to colonize and decompose plant tissues in various environments, there is scant information on their roles in leaf decomposition. This study focuses on the communities of zoosporic fungi and straminipiles in a stream which are involved in the decomposition of leaves of two plant species, Ligustrum lucidum and Pouteria salicifolia, in the presence of other groups of fungi. A characteristic community dominated by Nowakowskiella elegans, Phytophthora sp., and Pythium sp. was found. Changes in the fungal community structure over time (succession) was observed: terrestrial mitosporic fungi appeared during the early stages, zoosporic fungi, straminipiles, and aquatic Hyphomycetes in early-to-intermediate stages, while representatives of the phylum Zygomycota were found at early and latest stages of the decomposition. These observations highlight the importance of zoosporic fungi and straminipiles in aquatic ecosystems.
0018-8158HYDRB8Hydrobiologia : (Hague)659Diversity, role in decomposition, and succession of zoosporic fungi and straminipiles on submerged decaying leaves in a woodland streamDisregarded Microbial Diversity and Ecological Potentials in Aquatic SystemsMARANO (A. V.)PIRES-ZOTTARELLI (C. L. A.)BARRERA (M. D.)STECIOW (M. M.)GLEASON (F. H.)SIME-NGANDO (Télesphore)ed.NIQUIL (Nathalie)ed.Instituto de Botánica Spegazzini, Universidad Nacional de La Plata, calle 53 N 477La Plata, Buenos Aires 1900ARG1 aut.4 aut.Instituto de Botânica, CP 3005São Paulo, SP 01061-970BRA2 aut.Laboratorio de Investigación en Sistemas Ecológicos y Ambientales, Universidad Nacional de La Plata, Diagonal 113 N 469La Plata, Buenos AiresARG3 aut.School of Biological Sciences A12, University of SydneySydney, NSW 2006AUS5 aut.Lab. 'Microorganismes: Génome & Environnement', UMR CNRS 6023, Université Blaise Pascal63177 AubièreFRA1 aut.LIENSs (Littoral Environnement et Sociétés), UMR CNRS 6250, Université de la Rochelle, 2 rue Olympe de Gouge17000 La RochelleFRA2 aut.93-1092011ENGINIST53293540001918486100800000© 2011 INIST-CNRS. All rights reserved.2 p.3/411-0083790PAHydrobiologia : (The Hague)NLDLeaf litter is a very important primary source of energy in woodland streams. Decomposition of leaf litter is a process mediated by many groups of microorganisms which release extracellular enzymes for the degradation of complex macromolecules. In this process, true fungi and straminipiles are considered to be among the most active groups, more active than the bacteria, at least during the early stages of the process. Colonization increases the quality of the leaves as a food resource for detritivores. In this way, matter and energy enter detritus-based food chains. Previously, aquatic hyphomycetes were considered to be the major fungal group responsible for leaf litter decomposition. Although zoosporic fungi and straminipiles are known to colonize and decompose plant tissues in various environments, there is scant information on their roles in leaf decomposition. This study focuses on the communities of zoosporic fungi and straminipiles in a stream which are involved in the decomposition of leaves of two plant species, Ligustrum lucidum and Pouteria salicifolia, in the presence of other groups of fungi. A characteristic community dominated by Nowakowskiella elegans, Phytophthora sp., and Pythium sp. was found. Changes in the fungal community structure over time (succession) was observed: terrestrial mitosporic fungi appeared during the early stages, zoosporic fungi, straminipiles, and aquatic Hyphomycetes in early-to-intermediate stages, while representatives of the phylum Zygomycota were found at early and latest stages of the decomposition. These observations highlight the importance of zoosporic fungi and straminipiles in aquatic ecosystems.002A14B04A002A14B04CDiversité01Diversity01Diversidad01Décomposition02Decomposition02Descomposición02Feuille végétal03Plant leaf03Hoja vegetal03Cours eau04Stream04Curso agua04Milieu aquatique05Aquatic environment05Medio acuático05Ecosystème06Ecosystem06Ecosistema06Hydrobiologie07Hydrobiology07Hidrobiología07FungiNS49FungiNS49FungiNS49Forêt claireCD96WoodlandCD96Formación boscosaCD96052OTOOTOPASCAL 11-0083790 INISTDiversity, role in decomposition, and succession of zoosporic fungi and straminipiles on submerged decaying leaves in a woodland streamMARANO (A. V.); PIRES-ZOTTARELLI (C. L. A.); BARRERA (M. D.); STECIOW (M. M.); GLEASON (F. H.); SIME-NGANDO (Télesphore); NIQUIL (Nathalie)Instituto de Botánica Spegazzini, Universidad Nacional de La Plata, calle 53 N 477/La Plata, Buenos Aires 1900/Argentine (1 aut., 4 aut.); Instituto de Botânica, CP 3005/São Paulo, SP 01061-970/Brésil (2 aut.); Laboratorio de Investigación en Sistemas Ecológicos y Ambientales, Universidad Nacional de La Plata, Diagonal 113 N 469/La Plata, Buenos Aires/Argentine (3 aut.); School of Biological Sciences A12, University of Sydney/Sydney, NSW 2006/Australie (5 aut.); Lab. 'Microorganismes: Génome & Environnement', UMR CNRS 6023, Université Blaise Pascal/63177 Aubière/France (1 aut.); LIENSs (Littoral Environnement et Sociétés), UMR CNRS 6250, Université de la Rochelle, 2 rue Olympe de Gouge/17000 La Rochelle/France (2 aut.)
Publication en série; Niveau analytique
Hydrobiologia : (The Hague); ISSN 0018-8158; Coden HYDRB8; Pays-Bas; Da. 2011; Vol. 659; Pp. 93-109; Bibl. 2 p.3/4AnglaisLeaf litter is a very important primary source of energy in woodland streams. Decomposition of leaf litter is a process mediated by many groups of microorganisms which release extracellular enzymes for the degradation of complex macromolecules. In this process, true fungi and straminipiles are considered to be among the most active groups, more active than the bacteria, at least during the early stages of the process. Colonization increases the quality of the leaves as a food resource for detritivores. In this way, matter and energy enter detritus-based food chains. Previously, aquatic hyphomycetes were considered to be the major fungal group responsible for leaf litter decomposition. Although zoosporic fungi and straminipiles are known to colonize and decompose plant tissues in various environments, there is scant information on their roles in leaf decomposition. This study focuses on the communities of zoosporic fungi and straminipiles in a stream which are involved in the decomposition of leaves of two plant species, Ligustrum lucidum and Pouteria salicifolia, in the presence of other groups of fungi. A characteristic community dominated by Nowakowskiella elegans, Phytophthora sp., and Pythium sp. was found. Changes in the fungal community structure over time (succession) was observed: terrestrial mitosporic fungi appeared during the early stages, zoosporic fungi, straminipiles, and aquatic Hyphomycetes in early-to-intermediate stages, while representatives of the phylum Zygomycota were found at early and latest stages of the decomposition. These observations highlight the importance of zoosporic fungi and straminipiles in aquatic ecosystems.002A14B04A; 002A14B04CDiversité; Décomposition; Feuille végétal; Cours eau; Milieu aquatique; Ecosystème; Hydrobiologie; Fungi; Forêt claireDiversity; Decomposition; Plant leaf; Stream; Aquatic environment; Ecosystem; Hydrobiology; Fungi; WoodlandDiversidad; Descomposición; Hoja vegetal; Curso agua; Medio acuático; Ecosistema; Hidrobiología; Fungi; Formación boscosaINIST-5329.35400019184861008011-0083790 001601 Out of Australia and back again: the world-wide historical biogeography of non-pollinating fig wasps (Hymenoptera: Sycophaginae)Astrid CruaudINRA-UMR Centre de Biologie et de Gestion des Populations, CBGP, (INRA/IRD/CIRAD/ Montpellier SupAgro), Campus International de Baillarguet, CS 3001634988 Montferrier- sur LezFRA1 aut.2 aut.3 aut.12 aut.Roula Jabbour-ZahabINRA-UMR Centre de Biologie et de Gestion des Populations, CBGP, (INRA/IRD/CIRAD/ Montpellier SupAgro), Campus International de Baillarguet, CS 3001634988 Montferrier- sur LezFRA1 aut.2 aut.3 aut.12 aut.Gwenaëlle GensonINRA-UMR Centre de Biologie et de Gestion des Populations, CBGP, (INRA/IRD/CIRAD/ Montpellier SupAgro), Campus International de Baillarguet, CS 3001634988 Montferrier- sur LezFRA1 aut.2 aut.3 aut.12 aut.Arnaud CoulouxGénoscope, Centre National de Séquençage, 2 Rue Gaston Crémieux91057 EvryFRA4 aut.Yan-Qiong PengKey Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, 88 Xuefu Road650223 Kunming, YunnanCHN5 aut.6 aut.YANG DA RONGKey Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, 88 Xuefu Road650223 Kunming, YunnanCHN5 aut.6 aut.Rosichon UbaidillahEntomology Laboratory, Zoology Division (Museum Zoologicum Bogoriense), Center Research for Biology, LIPI, Gedung Widyasatwalaka Jl. Raya Jakarta- Bogor, Km 46Cobinong 16911, BogorIDN7 aut.Rodrigo Augusto Santinelo PereiraDepto de Biologia/FFCLRP-USP, Av. Bandeirantes, 390014040-901 - Ribeirão Preto, SPBRA8 aut.Finn KjellbergCNRS - UMR Centre d'Ecologie Fonctionnelle et Evolutive, CEFE, 1919 Route de Mende34293 MontpellierFRA9 aut.Simon Van NoortNatural History Division, South African Museum, Iziko Museums of Cape Town, PO Box 61Cape Town 8000ZAF10 aut.Department of Zoology, University of Cape Town, Private BagRondebosch, 7701ZAF10 aut.Carole KerdelhueINRA, UMR BioGeCo., 69 Route d'Arcachon33612 CestasFRA11 aut.Jean-Yves RasplusINRA-UMR Centre de Biologie et de Gestion des Populations, CBGP, (INRA/IRD/CIRAD/ Montpellier SupAgro), Campus International de Baillarguet, CS 3001634988 Montferrier- sur LezFRA1 aut.2 aut.3 aut.12 aut.11-00845182011PASCAL 11-0084518 INISTPascal:11-00845180012960305-0270J. biogeogr.Journal of biogeographyAustraliaBiogeographyCase historyCecidiogenDispersionFicusHymenopteraMarine environmentNinetyeast RidgePhylogenyWorldAustralieMondeHistoriqueBiogéographieDispersionCécidiogènePhylogenèseMilieu marinHymenopteraFicusDorsale de Nonante Est
Aim Figs (Ficus, Moraceae) are exploited by rich communities of often host-specific phytophagous wasps. Among them, gall-inducing Sycophaginae (Hymenoptera, Chalcidoidea) may share a common history with Ficus and their mutualistic pollinators (Agaonidae). We investigate here, for the first time, the phylogeny and biogeographical history of Sycophaginae and compare the timing of radiation and dispersion of major clades with available data on Ficus and fig pollinators. Reconstructing the history of their host colonization and association over space and time is central to understanding how fig wasp communities were assembled. Location World-wide. Methods Maximum likelihood and Bayesian analyses were conducted on 4267 bp of mitochondrial and nuclear DNA to produce a phylogeny of all genera of Sycophaginae. Two relaxed clock methods with or without rate autocorrelation were used for date estimation. Analyses of ancestral area were also conducted to investigate the geographical origin of the Sycophaginae. Results The phylogeny is well resolved and supported. Our data suggest a post-Gondwanan origin for the Sycophaginae (50-40 Ma) and two independent out-of-Australia dispersal events to continental Asia. Given palaeoclimatic and palaeogeographic records, the following scenario appears the most likely. The ancestor of Idarnes+Apocryptophagus migrated to Greater India through the Ninetyeast Ridge (40-30 Ma). The ancestor of Anidarnes+Conidarnes dispersed later via Sundaland (25-20 Ma). Idarnes and Anidarnes subsequently reached the New World via the North Atlantic land bridges during the Late Oligocene Warming Event. Apocryptophagus reached Africa c. 20 Ma via the Arabic corridors and returned to Australasia following the expansion of Sundaland tropical forests (20-10 Ma). Main conclusions Sycophaginae probably invaded the fig microcosm in Australia c. 50-40 Ma after the origin of their host plant. Once associated with figs, they dispersed out of Australia and radiated together with their host fig and associated pollinator through the tropics. We recorded a good coincidence of timing between dispersal events of Sycophaginae and continental connections. Furthermore, fruit pigeons that disperse figs probably spread out of Australasia through the Indian Ocean via the Ninetyeast Ridge c. 38 Ma. Therefore, our study highlights the potential for combining molecular phylogenetics with multiple methods of dating of interacting groups to reconstruct the historical biogeography of plant-herbivore associations.
0305-0270JBIODNJ. biogeogr.382Out of Australia and back again: the world-wide historical biogeography of non-pollinating fig wasps (Hymenoptera: Sycophaginae)CRUAUD (Astrid)JABBOUR-ZAHAB (Roula)GENSON (Gwenaëlle)COULOUX (Arnaud)PENG (Yan-Qiong)YANG DA RONGUBAIDILLAH (Rosichon)SANTINELO PEREIRA (Rodrigo Augusto)KJELLBERG (Finn)VAN NOORT (Simon)KERDELHUE (Carole)RASPLUS (Jean-Yves)INRA-UMR Centre de Biologie et de Gestion des Populations, CBGP, (INRA/IRD/CIRAD/ Montpellier SupAgro), Campus International de Baillarguet, CS 3001634988 Montferrier- sur LezFRA1 aut.2 aut.3 aut.12 aut.Génoscope, Centre National de Séquençage, 2 Rue Gaston Crémieux91057 EvryFRA4 aut.Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, 88 Xuefu Road650223 Kunming, YunnanCHN5 aut.6 aut.Entomology Laboratory, Zoology Division (Museum Zoologicum Bogoriense), Center Research for Biology, LIPI, Gedung Widyasatwalaka Jl. Raya Jakarta- Bogor, Km 46Cobinong 16911, BogorIDN7 aut.Depto de Biologia/FFCLRP-USP, Av. Bandeirantes, 390014040-901 - Ribeirão Preto, SPBRA8 aut.CNRS - UMR Centre d'Ecologie Fonctionnelle et Evolutive, CEFE, 1919 Route de Mende34293 MontpellierFRA9 aut.Natural History Division, South African Museum, Iziko Museums of Cape Town, PO Box 61Cape Town 8000ZAF10 aut.Department of Zoology, University of Cape Town, Private BagRondebosch, 7701ZAF10 aut.INRA, UMR BioGeCo., 69 Route d'Arcachon33612 CestasFRA11 aut.209-2252011ENGINIST156983540001935746700100000© 2011 INIST-CNRS. All rights reserved.3 p.11-0084518PAJournal of biogeographyGBRAim Figs (Ficus, Moraceae) are exploited by rich communities of often host-specific phytophagous wasps. Among them, gall-inducing Sycophaginae (Hymenoptera, Chalcidoidea) may share a common history with Ficus and their mutualistic pollinators (Agaonidae). We investigate here, for the first time, the phylogeny and biogeographical history of Sycophaginae and compare the timing of radiation and dispersion of major clades with available data on Ficus and fig pollinators. Reconstructing the history of their host colonization and association over space and time is central to understanding how fig wasp communities were assembled. Location World-wide. Methods Maximum likelihood and Bayesian analyses were conducted on 4267 bp of mitochondrial and nuclear DNA to produce a phylogeny of all genera of Sycophaginae. Two relaxed clock methods with or without rate autocorrelation were used for date estimation. Analyses of ancestral area were also conducted to investigate the geographical origin of the Sycophaginae. Results The phylogeny is well resolved and supported. Our data suggest a post-Gondwanan origin for the Sycophaginae (50-40 Ma) and two independent out-of-Australia dispersal events to continental Asia. Given palaeoclimatic and palaeogeographic records, the following scenario appears the most likely. The ancestor of Idarnes+Apocryptophagus migrated to Greater India through the Ninetyeast Ridge (40-30 Ma). The ancestor of Anidarnes+Conidarnes dispersed later via Sundaland (25-20 Ma). Idarnes and Anidarnes subsequently reached the New World via the North Atlantic land bridges during the Late Oligocene Warming Event. Apocryptophagus reached Africa c. 20 Ma via the Arabic corridors and returned to Australasia following the expansion of Sundaland tropical forests (20-10 Ma). Main conclusions Sycophaginae probably invaded the fig microcosm in Australia c. 50-40 Ma after the origin of their host plant. Once associated with figs, they dispersed out of Australia and radiated together with their host fig and associated pollinator through the tropics. We recorded a good coincidence of timing between dispersal events of Sycophaginae and continental connections. Furthermore, fruit pigeons that disperse figs probably spread out of Australasia through the Indian Ocean via the Ninetyeast Ridge c. 38 Ma. Therefore, our study highlights the potential for combining molecular phylogenetics with multiple methods of dating of interacting groups to reconstruct the historical biogeography of plant-herbivore associations.002A14B04A002A12JAustralieNG01AustraliaNG01AustraliaNG01MondeNG02WorldNG02MundoNG02Historique03Case history03Estudio histórico03Biogéographie04Biogeography04Biogeografía04Dispersion05Dispersion05Dispersión05Cécidiogène06Cecidiogen06Cecidiógeno06Phylogenèse07Phylogeny07Filogénesis07Milieu marin23Marine environment23Medio marino23HymenopteraNS49HymenopteraNS49HymenopteraNS49FicusNS50FicusNS50FicusNS50Dorsale de Nonante EstCD96Ninetyeast RidgeCD96Dorsal de Nonante EsteCD96OcéanieNGOceaniaNGOceaniaNGPlante ligneuse32Woody plant32Planta leñosa32InsectaNSInsectaNSInsectaNSArthropodaNSArthropodaNSArthropodaNSInvertebrataNSInvertebrataNSInvertebrataNSMoraceaeNSMoraceaeNSMoraceaeNSDicotyledonesNSDicotyledonesNSDicotyledonesNSAngiospermaeNSAngiospermaeNSAngiospermaeNSSpermatophytaNSSpermatophytaNSSpermatophytaNS052OTOOTOPASCAL 11-0084518 INISTOut of Australia and back again: the world-wide historical biogeography of non-pollinating fig wasps (Hymenoptera: Sycophaginae)CRUAUD (Astrid); JABBOUR-ZAHAB (Roula); GENSON (Gwenaëlle); COULOUX (Arnaud); PENG (Yan-Qiong); YANG DA RONG; UBAIDILLAH (Rosichon); SANTINELO PEREIRA (Rodrigo Augusto); KJELLBERG (Finn); VAN NOORT (Simon); KERDELHUE (Carole); RASPLUS (Jean-Yves)INRA-UMR Centre de Biologie et de Gestion des Populations, CBGP, (INRA/IRD/CIRAD/ Montpellier SupAgro), Campus International de Baillarguet, CS 30016/34988 Montferrier- sur Lez/France (1 aut., 2 aut., 3 aut., 12 aut.); Génoscope, Centre National de Séquençage, 2 Rue Gaston Crémieux/91057 Evry/France (4 aut.); Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, 88 Xuefu Road/650223 Kunming, Yunnan/Chine (5 aut., 6 aut.); Entomology Laboratory, Zoology Division (Museum Zoologicum Bogoriense), Center Research for Biology, LIPI, Gedung Widyasatwalaka Jl. Raya Jakarta- Bogor, Km 46/Cobinong 16911, Bogor/Indonésie (7 aut.); Depto de Biologia/FFCLRP-USP, Av. Bandeirantes, 3900/14040-901 - Ribeirão Preto, SP/Brésil (8 aut.); CNRS - UMR Centre d'Ecologie Fonctionnelle et Evolutive, CEFE, 1919 Route de Mende/34293 Montpellier/France (9 aut.); Natural History Division, South African Museum, Iziko Museums of Cape Town, PO Box 61/Cape Town 8000/Afrique du Sud (10 aut.); Department of Zoology, University of Cape Town, Private Bag/Rondebosch, 7701/Afrique du Sud (10 aut.); INRA, UMR BioGeCo., 69 Route d'Arcachon/33612 Cestas/France (11 aut.)
Publication en série; Niveau analytique
Journal of biogeography; ISSN 0305-0270; Coden JBIODN; Royaume-Uni; Da. 2011; Vol. 38; No. 2; Pp. 209-225; Bibl. 3 p.AnglaisAim Figs (Ficus, Moraceae) are exploited by rich communities of often host-specific phytophagous wasps. Among them, gall-inducing Sycophaginae (Hymenoptera, Chalcidoidea) may share a common history with Ficus and their mutualistic pollinators (Agaonidae). We investigate here, for the first time, the phylogeny and biogeographical history of Sycophaginae and compare the timing of radiation and dispersion of major clades with available data on Ficus and fig pollinators. Reconstructing the history of their host colonization and association over space and time is central to understanding how fig wasp communities were assembled. Location World-wide. Methods Maximum likelihood and Bayesian analyses were conducted on 4267 bp of mitochondrial and nuclear DNA to produce a phylogeny of all genera of Sycophaginae. Two relaxed clock methods with or without rate autocorrelation were used for date estimation. Analyses of ancestral area were also conducted to investigate the geographical origin of the Sycophaginae. Results The phylogeny is well resolved and supported. Our data suggest a post-Gondwanan origin for the Sycophaginae (50-40 Ma) and two independent out-of-Australia dispersal events to continental Asia. Given palaeoclimatic and palaeogeographic records, the following scenario appears the most likely. The ancestor of Idarnes+Apocryptophagus migrated to Greater India through the Ninetyeast Ridge (40-30 Ma). The ancestor of Anidarnes+Conidarnes dispersed later via Sundaland (25-20 Ma). Idarnes and Anidarnes subsequently reached the New World via the North Atlantic land bridges during the Late Oligocene Warming Event. Apocryptophagus reached Africa c. 20 Ma via the Arabic corridors and returned to Australasia following the expansion of Sundaland tropical forests (20-10 Ma). Main conclusions Sycophaginae probably invaded the fig microcosm in Australia c. 50-40 Ma after the origin of their host plant. Once associated with figs, they dispersed out of Australia and radiated together with their host fig and associated pollinator through the tropics. We recorded a good coincidence of timing between dispersal events of Sycophaginae and continental connections. Furthermore, fruit pigeons that disperse figs probably spread out of Australasia through the Indian Ocean via the Ninetyeast Ridge c. 38 Ma. Therefore, our study highlights the potential for combining molecular phylogenetics with multiple methods of dating of interacting groups to reconstruct the historical biogeography of plant-herbivore associations.002A14B04A; 002A12JAustralie; Monde; Historique; Biogéographie; Dispersion; Cécidiogène; Phylogenèse; Milieu marin; Hymenoptera; Ficus; Dorsale de Nonante EstOcéanie; Plante ligneuse; Insecta; Arthropoda; Invertebrata; Moraceae; Dicotyledones; Angiospermae; SpermatophytaAustralia; World; Case history; Biogeography; Dispersion; Cecidiogen; Phylogeny; Marine environment; Hymenoptera; Ficus; Ninetyeast RidgeOceania; Woody plant; Insecta; Arthropoda; Invertebrata; Moraceae; Dicotyledones; Angiospermae; SpermatophytaAustralia; Mundo; Estudio histórico; Biogeografía; Dispersión; Cecidiógeno; Filogénesis; Medio marino; Hymenoptera; Ficus; Dorsal de Nonante EsteINIST-15698.35400019357467001011-0084518 001602 Effect of sugarcane harvesting systems on soil carbon stocks in Brazil: an examination of existing dataC. C. CerriCentro de Energia Nuclear na Agricultura (CENA/USP), Universidade de Sao Paulo, Av. Centenario 303CEP. 13400-970, PiracicabaBRA1 aut.2 aut.3 aut.5 aut.M. V. GaldosCentro de Energia Nuclear na Agricultura (CENA/USP), Universidade de Sao Paulo, Av. Centenario 303CEP. 13400-970, PiracicabaBRA1 aut.2 aut.3 aut.5 aut.S. M. F. MaiaCentro de Energia Nuclear na Agricultura (CENA/USP), Universidade de Sao Paulo, Av. Centenario 303CEP. 13400-970, PiracicabaBRA1 aut.2 aut.3 aut.5 aut.M. BernouxInstitut de Recherche pour le Développement (IRD), UMR Eco&Sols (Inra, IRD, SupAgro), 2 place Viala - Bat. 1234060 MontpellierFRA4 aut.B. J. FeiglCentro de Energia Nuclear na Agricultura (CENA/USP), Universidade de Sao Paulo, Av. Centenario 303CEP. 13400-970, PiracicabaBRA1 aut.2 aut.3 aut.5 aut.D. PowlsonRothamsted Research, Soil Science DepartmentHarpenden, AL5 2JQGBR6 aut.C. E. P. CerriEscola Superior de Agricultura Luiz de Queiroz (ESALQ/USP), Universidade de Sao Paulo, Av. Padua Dias 11CEP. 13418-900, PiracicabaBRA7 aut.11-00845532011PASCAL 11-0084553 INISTPascal:11-00845530012951351-0754Eur. j. soil sci.European journal of soil scienceBrazilCarbon contentEarth scienceSaccharum officinarumSoil scienceSugar caneSystemTropical cropcollectingdatasoilsRécolteSystèmeTeneur carboneDonnéeScience terreScience du solCulture tropicaleSaccharum officinarumCanne à sucreBrésilSolPlante en C4
Agricultural management practices that promote net carbon (C) accumulation in the soil have been considered as an important potential mitigation option to combat global warming. The change in the sugarcane harvesting system, to one which incorporates C into the soil from crop residues, is the focus of this work. The main objective was to assess and discuss the changes in soil organic C stocks caused by the conversion of burnt to unburnt sugarcane harvesting systems in Brazil, when considering the main soils and climates associated with this crop. For this purpose, a dataset was obtained from a literature review of soils under sugarcane in Brazil. Although not necessarily from experimental studies, only paired comparisons were examined, and for each site the dominant soil type, topography and climate were similar. The results show a mean annual C accumulation rate of 1.5 Mg ha-1 year-1 for the surface to 30-cm depth (0.73 and 2.04 Mg ha-1 year-1 for sandy and clay soils, respectively) caused by the conversion from a burnt to an unburnt sugarcane harvesting system. The findings suggest that soil should be included in future studies related to life cycle assessment and C footprint of Brazilian sugarcane ethanol.
1351-0754Eur. j. soil sci.621Effect of sugarcane harvesting systems on soil carbon stocks in Brazil: an examination of existing dataCERRI (C. C.)GALDOS (M. V.)MAIA (S. M. F.)BERNOUX (M.)FEIGL (B. J.)POWLSON (D.)CERRI (C. E. P.)Centro de Energia Nuclear na Agricultura (CENA/USP), Universidade de Sao Paulo, Av. Centenario 303CEP. 13400-970, PiracicabaBRA1 aut.2 aut.3 aut.5 aut.Institut de Recherche pour le Développement (IRD), UMR Eco&Sols (Inra, IRD, SupAgro), 2 place Viala - Bat. 1234060 MontpellierFRA4 aut.Rothamsted Research, Soil Science DepartmentHarpenden, AL5 2JQGBR6 aut.Escola Superior de Agricultura Luiz de Queiroz (ESALQ/USP), Universidade de Sao Paulo, Av. Padua Dias 11CEP. 13418-900, PiracicabaBRA7 aut.23-282011ENGINIST24023540001935751700300000© 2011 INIST-CNRS. All rights reserved.1 p.1/411-0084553PAEuropean journal of soil scienceGBRAgricultural management practices that promote net carbon (C) accumulation in the soil have been considered as an important potential mitigation option to combat global warming. The change in the sugarcane harvesting system, to one which incorporates C into the soil from crop residues, is the focus of this work. The main objective was to assess and discuss the changes in soil organic C stocks caused by the conversion of burnt to unburnt sugarcane harvesting systems in Brazil, when considering the main soils and climates associated with this crop. For this purpose, a dataset was obtained from a literature review of soils under sugarcane in Brazil. Although not necessarily from experimental studies, only paired comparisons were examined, and for each site the dominant soil type, topography and climate were similar. The results show a mean annual C accumulation rate of 1.5 Mg ha-1 year-1 for the surface to 30-cm depth (0.73 and 2.04 Mg ha-1 year-1 for sandy and clay soils, respectively) caused by the conversion from a burnt to an unburnt sugarcane harvesting system. The findings suggest that soil should be included in future studies related to life cycle assessment and C footprint of Brazilian sugarcane ethanol.001E01P03002A32B226C03Récolte01collecting01Cosecha01Système02System02Sistema02Teneur carbone03Carbon content03Contenido carbono03Donnée04data04Dato04Science terre05Earth science05Ciencia tierra05Science du sol06Soil science06Ciencia del suelo06Culture tropicale07Tropical crop07Cultivo tropical07Saccharum officinarumNS10Saccharum officinarumNS10Saccharum officinarumNS10Canne à sucre15Sugar cane15Caña de azúcar15BrésilNG20BrazilNG20BrasilNG20SolNT24soilsNT24SueloNT24Plante en C4INC68GramineaeNSGramineaeNSGramineaeNSMonocotyledonesNSMonocotyledonesNSMonocotyledonesNSAngiospermaeNSAngiospermaeNSAngiospermaeNSSpermatophytaNSSpermatophytaNSSpermatophytaNSAmérique du Sud564South America564America del sur564Type C431C4-Type31Tipo C431Plante sucrière32Sugar plant32Planta azucarera32Composition chimique33chemical composition33Végétal39Vegetals39Vegetal39052OTOOTOPASCAL 11-0084553 INISTEffect of sugarcane harvesting systems on soil carbon stocks in Brazil: an examination of existing dataCERRI (C. C.); GALDOS (M. V.); MAIA (S. M. F.); BERNOUX (M.); FEIGL (B. J.); POWLSON (D.); CERRI (C. E. P.)Centro de Energia Nuclear na Agricultura (CENA/USP), Universidade de Sao Paulo, Av. Centenario 303/CEP. 13400-970, Piracicaba/Brésil (1 aut., 2 aut., 3 aut., 5 aut.); Institut de Recherche pour le Développement (IRD), UMR Eco&Sols (Inra, IRD, SupAgro), 2 place Viala - Bat. 12/34060 Montpellier/France (4 aut.); Rothamsted Research, Soil Science Department/Harpenden, AL5 2JQ/Royaume-Uni (6 aut.); Escola Superior de Agricultura Luiz de Queiroz (ESALQ/USP), Universidade de Sao Paulo, Av. Padua Dias 11/CEP. 13418-900, Piracicaba/Brésil (7 aut.)
Publication en série; Niveau analytique
European journal of soil science; ISSN 1351-0754; Royaume-Uni; Da. 2011; Vol. 62; No. 1; Pp. 23-28; Bibl. 1 p.1/4AnglaisAgricultural management practices that promote net carbon (C) accumulation in the soil have been considered as an important potential mitigation option to combat global warming. The change in the sugarcane harvesting system, to one which incorporates C into the soil from crop residues, is the focus of this work. The main objective was to assess and discuss the changes in soil organic C stocks caused by the conversion of burnt to unburnt sugarcane harvesting systems in Brazil, when considering the main soils and climates associated with this crop. For this purpose, a dataset was obtained from a literature review of soils under sugarcane in Brazil. Although not necessarily from experimental studies, only paired comparisons were examined, and for each site the dominant soil type, topography and climate were similar. The results show a mean annual C accumulation rate of 1.5 Mg ha-1 year-1 for the surface to 30-cm depth (0.73 and 2.04 Mg ha-1 year-1 for sandy and clay soils, respectively) caused by the conversion from a burnt to an unburnt sugarcane harvesting system. The findings suggest that soil should be included in future studies related to life cycle assessment and C footprint of Brazilian sugarcane ethanol.001E01P03; 002A32B; 226C03Récolte; Système; Teneur carbone; Donnée; Science terre; Science du sol; Culture tropicale; Saccharum officinarum; Canne à sucre; Brésil; Sol; Plante en C4Gramineae; Monocotyledones; Angiospermae; Spermatophyta; Amérique du Sud; Type C4; Plante sucrière; Composition chimique; Végétalcollecting; System; Carbon content; data; Earth science; Soil science; Tropical crop; Saccharum officinarum; Sugar cane; Brazil; soilsGramineae; Monocotyledones; Angiospermae; Spermatophyta; South America; C4-Type; Sugar plant; chemical composition; VegetalsCosecha; Sistema; Contenido carbono; Dato; Ciencia tierra; Ciencia del suelo; Cultivo tropical; Saccharum officinarum; Caña de azúcar; Brasil; SueloINIST-2402.35400019357517003011-0084553 001603 Similar behaviors of sulfide and selenide-based chalcogenide glasses to form glass-ceramicsLaurent CalvezLaboratoire des Verres et Céramiques, UMR-CNRS 6226, Sciences chimiques de Rennes, Université de Rennes 135042 RennesFRA1 aut.3 aut.5 aut.6 aut.8 aut.CHANGGUI LINKey Laboratory of Silicate Materials Science and Engineering (Wuhan University of Technology), Ministry of EducationWuhan, Hubei 430070CHN2 aut.Mathieu RozeLaboratoire des Verres et Céramiques, UMR-CNRS 6226, Sciences chimiques de Rennes, Université de Rennes 135042 RennesFRA1 aut.3 aut.5 aut.6 aut.8 aut.Yannick LedemiLaboratorio dos Materials Fôtonicos, Instituto de QuimicaCampus de AraraquaraBRA4 aut.Erwan GuillevicLaboratoire des Verres et Céramiques, UMR-CNRS 6226, Sciences chimiques de Rennes, Université de Rennes 135042 RennesFRA1 aut.3 aut.5 aut.6 aut.8 aut.Bruno BureauLaboratoire des Verres et Céramiques, UMR-CNRS 6226, Sciences chimiques de Rennes, Université de Rennes 135042 RennesFRA1 aut.3 aut.5 aut.6 aut.8 aut.Mathieu AllixCNRS, UPR3079 CEMHTI, 1D Avenue de la Recherche Scientifique45071 OrléansFRA7 aut.Université d'Orléans, Avenue du Parc Floral, BP 674945067 OrléansFRA7 aut.XIANGHUA ZHANGLaboratoire des Verres et Céramiques, UMR-CNRS 6226, Sciences chimiques de Rennes, Université de Rennes 135042 RennesFRA1 aut.3 aut.5 aut.6 aut.8 aut.11-00855902010PASCAL 11-0085590 INISTPascal:11-00855900012940277-786XProc. SPIE Int. Soc. Opt. Eng.Proceedings of SPIE, the International Society for Optical EngineeringAlkali metal halidesChalcogenide glassesGallium SelenidesGallium SulfidesGermanium SelenidesGermanium SulfidesGlass ceramicsMechanical propertiesNanocrystalNanostructured materialsOptical materialsPhotoluminescenceTransmittanceXRDPhotoluminescenceDiffraction RXFacteur transmissionPropriété mécaniqueNanocristalNanomatériauMatériau optiqueGermanium SéléniureGallium SulfureVerre chalcogénureVitrocéramiqueMétal alcalin halogénureGallium SéléniureGermanium Sulfure4270C0130C
In this paper, the strong influence of alkali halide in chalcogenide glasses is reminded, leading for the first time to highly transparent glasses from the visible range up to 11 μm. The behavior of crystallization has been demonstrated to be similar in sulfide and selenide glasses containing gallium as well. The structural evolution of several glass compositions from the Ge-Ga-S or Ge-Ga-Se systems leading to reproducible glass-ceramics has been studied by XRD, NMR and thermal analysis. Whatever the composition, gallium plays a fundamental role as nanosized domains appear by phase separation between Ge rich regions and Ga rich regions. The determination of the appropriate crystallization time and temperature has permitted to obtain new passive and active glass-ceramics with a broadened transmittance region thanks to the incorporation of various alkali halides. In the first case, the controllable generation of nanocrystals leads to an increase of the main thermo-mechanical properties. In the second case, the incorporation of rare-earth ions inside the glass-ceramics has exacerbated their photoluminescence properties. The possibility to combine the ceramization process with the shaping has also been demonstrated.
0277-786XPSISDGProc. SPIE Int. Soc. Opt. Eng.7598Similar behaviors of sulfide and selenide-based chalcogenide glasses to form glass-ceramicsOptical components and materials VII : 26-28 January 2010, San Francisco, California, United StatesCALVEZ (Laurent)CHANGGUI LINROZE (Mathieu)LEDEMI (Yannick)GUILLEVIC (Erwan)BUREAU (Bruno)ALLIX (Mathieu)XIANGHUA ZHANGJIANG (Shibin)ed.Laboratoire des Verres et Céramiques, UMR-CNRS 6226, Sciences chimiques de Rennes, Université de Rennes 135042 RennesFRA1 aut.3 aut.5 aut.6 aut.8 aut.Key Laboratory of Silicate Materials Science and Engineering (Wuhan University of Technology), Ministry of EducationWuhan, Hubei 430070CHN2 aut.Laboratorio dos Materials Fôtonicos, Instituto de QuimicaCampus de AraraquaraBRA4 aut.CNRS, UPR3079 CEMHTI, 1D Avenue de la Recherche Scientifique45071 OrléansFRA7 aut.Université d'Orléans, Avenue du Parc Floral, BP 674945067 OrléansFRA7 aut.SPIEUSAorg-cong.759802.1-759802.162010ENGSPIEBellingham, Wash.0-8194-7994-2978-0-8194-7994-5INIST217603540001746972800100000© 2011 INIST-CNRS. All rights reserved.35 ref.11-0085590PCAProceedings of SPIE, the International Society for Optical EngineeringUSAIn this paper, the strong influence of alkali halide in chalcogenide glasses is reminded, leading for the first time to highly transparent glasses from the visible range up to 11 μm. The behavior of crystallization has been demonstrated to be similar in sulfide and selenide glasses containing gallium as well. The structural evolution of several glass compositions from the Ge-Ga-S or Ge-Ga-Se systems leading to reproducible glass-ceramics has been studied by XRD, NMR and thermal analysis. Whatever the composition, gallium plays a fundamental role as nanosized domains appear by phase separation between Ge rich regions and Ga rich regions. The determination of the appropriate crystallization time and temperature has permitted to obtain new passive and active glass-ceramics with a broadened transmittance region thanks to the incorporation of various alkali halides. In the first case, the controllable generation of nanocrystals leads to an increase of the main thermo-mechanical properties. In the second case, the incorporation of rare-earth ions inside the glass-ceramics has exacerbated their photoluminescence properties. The possibility to combine the ceramization process with the shaping has also been demonstrated.001B40B70C001B00A30CPhotoluminescence03Photoluminescence03Diffraction RX30XRD30Facteur transmission41Transmittance41Factor transmisión41Propriété mécanique42Mechanical properties42Nanocristal47Nanocrystal47Nanocristal47Nanomatériau50Nanostructured materials50Matériau optique57Optical materials57Germanium SéléniureNCNA61Germanium SelenidesNCNA61Gallium SulfureNCNA62Gallium SulfidesNCNA62Verre chalcogénure63Chalcogenide glasses63Vitrocéramique64Glass ceramics64Métal alcalin halogénure65Alkali metal halides65Gallium SéléniureNCNA67Gallium SelenidesNCNA67Germanium SulfureNCNA68Germanium SulfidesNCNA684270CINC830130CINC84059OTOOTOOptical components and materials07San Francisco CA USA2010PASCAL 11-0085590 INISTSimilar behaviors of sulfide and selenide-based chalcogenide glasses to form glass-ceramicsCALVEZ (Laurent); CHANGGUI LIN; ROZE (Mathieu); LEDEMI (Yannick); GUILLEVIC (Erwan); BUREAU (Bruno); ALLIX (Mathieu); XIANGHUA ZHANG; JIANG (Shibin)Laboratoire des Verres et Céramiques, UMR-CNRS 6226, Sciences chimiques de Rennes, Université de Rennes 1/35042 Rennes/France (1 aut., 3 aut., 5 aut., 6 aut., 8 aut.); Key Laboratory of Silicate Materials Science and Engineering (Wuhan University of Technology), Ministry of Education/Wuhan, Hubei 430070/Chine (2 aut.); Laboratorio dos Materials Fôtonicos, Instituto de Quimica/Campus de Araraquara/Brésil (4 aut.); CNRS, UPR3079 CEMHTI, 1D Avenue de la Recherche Scientifique/45071 Orléans/France (7 aut.); Université d'Orléans, Avenue du Parc Floral, BP 6749/45067 Orléans/France (7 aut.)
Publication en série; Congrès; Niveau analytique
Proceedings of SPIE, the International Society for Optical Engineering; ISSN 0277-786X; Coden PSISDG; Etats-Unis; Da. 2010; Vol. 7598; 759802.1-759802.16; Bibl. 35 ref.AnglaisIn this paper, the strong influence of alkali halide in chalcogenide glasses is reminded, leading for the first time to highly transparent glasses from the visible range up to 11 μm. The behavior of crystallization has been demonstrated to be similar in sulfide and selenide glasses containing gallium as well. The structural evolution of several glass compositions from the Ge-Ga-S or Ge-Ga-Se systems leading to reproducible glass-ceramics has been studied by XRD, NMR and thermal analysis. Whatever the composition, gallium plays a fundamental role as nanosized domains appear by phase separation between Ge rich regions and Ga rich regions. The determination of the appropriate crystallization time and temperature has permitted to obtain new passive and active glass-ceramics with a broadened transmittance region thanks to the incorporation of various alkali halides. In the first case, the controllable generation of nanocrystals leads to an increase of the main thermo-mechanical properties. In the second case, the incorporation of rare-earth ions inside the glass-ceramics has exacerbated their photoluminescence properties. The possibility to combine the ceramization process with the shaping has also been demonstrated.001B40B70C; 001B00A30CPhotoluminescence; Diffraction RX; Facteur transmission; Propriété mécanique; Nanocristal; Nanomatériau; Matériau optique; Germanium Séléniure; Gallium Sulfure; Verre chalcogénure; Vitrocéramique; Métal alcalin halogénure; Gallium Séléniure; Germanium Sulfure; 4270C; 0130CPhotoluminescence; XRD; Transmittance; Mechanical properties; Nanocrystal; Nanostructured materials; Optical materials; Germanium Selenides; Gallium Sulfides; Chalcogenide glasses; Glass ceramics; Alkali metal halides; Gallium Selenides; Germanium SulfidesFactor transmisión; NanocristalINIST-21760.35400017469728001011-0085590 001604 Session 2: Micronutrients and the immune system Nutritional imbalances and infections affect the thymus: consequences on T-cell-mediated immune responsesWilson SavingLaboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz FoundationRio de JaneiroBRA1 aut.Mireille DardenneHôpital Necker, Université Paris Descartes, CNRS UMR-8147ParisFRA2 aut.11-00872762010PASCAL 11-0087276 INISTPascal:11-00872760012930029-6651Proc. Nutr. Soc.Proceedings of the Nutrition SocietyCellular immunityChagas diseaseExtracellular matrixImmune systemInfectionMalnutritionMammaliaMicronutrientNutritionT-LymphocyteThymocyteMicronutrimentSystème immunitaireNutritionInfectionLymphocyte TImmunité cellulaireThymocyteMatrice extracellulaireMalnutritionMammaliaTrypanosomiase américaine
The thymus gland, where T lymphocyte development occurs, is targeted in malnutrition secondary to protein energy deficiency. There is a severe thymic atrophy, resulting from massive thymocyte apoptosis (particularly affecting the immature CD4+CD8+ cell subset) and decrease in cell proliferation. The thymic microenvironment (the non-lymphoid compartment that drives intrathymic T-cell development) is also affected in malnutrition: morphological changes in thymic epithelial cells were found, together with a decrease of thymic hormone production, as well as an increase of intrathymic contents of extracellular proteins. Profound changes in the thymus can also be seen in deficiencies of vitamins and trace elements. Taking Zn deficiency as an example, there is a substantial thymic atrophy. Importantly, marginal Zn deficiency in AIDS subjects, children with diarrhoea and elderly persons, significantly impairs the host's immunity, resulting in an increased risk of opportunistic infections and mortality; effects that are reversed by Zn supplementation. Thymic changes also occur in acute infectious diseases, including a severe thymic atrophy, mainly due to the depletion of CD4+CD8+ thymocytes, decrease in thymocyte proliferation, in parallel to densification of the epithelial network and increase in the extracellular matrix contents, with consequent disturbances in thymocyte migration and export. In conclusion, the thymus is targeted in several conditions of malnutrition as well as in acute infections. These changes are related to the impaired peripheral immune response seen in malnourished and infected individuals. Thus, strategies inducing thymus replenishment should be considered as adjuvant therapeutics to improve immunity in malnutrition and/or acute infectious diseases.
0029-6651PNUSA4Proc. Nutr. Soc.694Session 2: Micronutrients and the immune system Nutritional imbalances and infections affect the thymus: consequences on T-cell-mediated immune responsesSAVING (Wilson)DARDENNE (Mireille)Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz FoundationRio de JaneiroBRA1 aut.Hôpital Necker, Université Paris Descartes, CNRS UMR-8147ParisFRA2 aut.636-6432010ENGINIST10013540001934016602200000© 2011 INIST-CNRS. All rights reserved.66 ref.11-0087276PCAProceedings of the Nutrition SocietyGBRThe thymus gland, where T lymphocyte development occurs, is targeted in malnutrition secondary to protein energy deficiency. There is a severe thymic atrophy, resulting from massive thymocyte apoptosis (particularly affecting the immature CD4+CD8+ cell subset) and decrease in cell proliferation. The thymic microenvironment (the non-lymphoid compartment that drives intrathymic T-cell development) is also affected in malnutrition: morphological changes in thymic epithelial cells were found, together with a decrease of thymic hormone production, as well as an increase of intrathymic contents of extracellular proteins. Profound changes in the thymus can also be seen in deficiencies of vitamins and trace elements. Taking Zn deficiency as an example, there is a substantial thymic atrophy. Importantly, marginal Zn deficiency in AIDS subjects, children with diarrhoea and elderly persons, significantly impairs the host's immunity, resulting in an increased risk of opportunistic infections and mortality; effects that are reversed by Zn supplementation. Thymic changes also occur in acute infectious diseases, including a severe thymic atrophy, mainly due to the depletion of CD4+CD8+ thymocytes, decrease in thymocyte proliferation, in parallel to densification of the epithelial network and increase in the extracellular matrix contents, with consequent disturbances in thymocyte migration and export. In conclusion, the thymus is targeted in several conditions of malnutrition as well as in acute infections. These changes are related to the impaired peripheral immune response seen in malnourished and infected individuals. Thus, strategies inducing thymus replenishment should be considered as adjuvant therapeutics to improve immunity in malnutrition and/or acute infectious diseases.002A16EMicronutriment01Micronutrient01Micronutriente01Système immunitaire02Immune system02Sistema inmunitario02Nutrition03Nutrition03Nutrición03Infection04Infection04Infección04Lymphocyte T05T-Lymphocyte05Linfocito T05Immunité cellulaire06Cellular immunity06Inmunidad celular06Thymocyte07Thymocyte07Timocito07Matrice extracellulaire08Extracellular matrix08Matriz extracelular08Malnutrition09Malnutrition09Malnutrición09MammaliaNS10MammaliaNS10MammaliaNS10Trypanosomiase américaine12Chagas disease12Tripanosomiasis americana12VertebrataNSVertebrataNSVertebrataNSTrypanosomiaseTrypanosomiasisTripanosomiasisProtozooseProtozoal diseaseProtozoosisParasitoseParasitosisParasitosisTrouble de la nutrition20Nutrition disorder20Trastorno nutricíon20059OTOOTOThe 3rd International Immunonutrition Workshop3Girona ESP2009-10-21PASCAL 11-0087276 INISTSession 2: Micronutrients and the immune system Nutritional imbalances and infections affect the thymus: consequences on T-cell-mediated immune responsesSAVING (Wilson); DARDENNE (Mireille)Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation/Rio de Janeiro/Brésil (1 aut.); Hôpital Necker, Université Paris Descartes, CNRS UMR-8147/Paris/France (2 aut.)
Publication en série; Congrès; Niveau analytique
Proceedings of the Nutrition Society; ISSN 0029-6651; Coden PNUSA4; Royaume-Uni; Da. 2010; Vol. 69; No. 4; Pp. 636-643; Bibl. 66 ref.AnglaisThe thymus gland, where T lymphocyte development occurs, is targeted in malnutrition secondary to protein energy deficiency. There is a severe thymic atrophy, resulting from massive thymocyte apoptosis (particularly affecting the immature CD4+CD8+ cell subset) and decrease in cell proliferation. The thymic microenvironment (the non-lymphoid compartment that drives intrathymic T-cell development) is also affected in malnutrition: morphological changes in thymic epithelial cells were found, together with a decrease of thymic hormone production, as well as an increase of intrathymic contents of extracellular proteins. Profound changes in the thymus can also be seen in deficiencies of vitamins and trace elements. Taking Zn deficiency as an example, there is a substantial thymic atrophy. Importantly, marginal Zn deficiency in AIDS subjects, children with diarrhoea and elderly persons, significantly impairs the host's immunity, resulting in an increased risk of opportunistic infections and mortality; effects that are reversed by Zn supplementation. Thymic changes also occur in acute infectious diseases, including a severe thymic atrophy, mainly due to the depletion of CD4+CD8+ thymocytes, decrease in thymocyte proliferation, in parallel to densification of the epithelial network and increase in the extracellular matrix contents, with consequent disturbances in thymocyte migration and export. In conclusion, the thymus is targeted in several conditions of malnutrition as well as in acute infections. These changes are related to the impaired peripheral immune response seen in malnourished and infected individuals. Thus, strategies inducing thymus replenishment should be considered as adjuvant therapeutics to improve immunity in malnutrition and/or acute infectious diseases.002A16EMicronutriment; Système immunitaire; Nutrition; Infection; Lymphocyte T; Immunité cellulaire; Thymocyte; Matrice extracellulaire; Malnutrition; Mammalia; Trypanosomiase américaineVertebrata; Trypanosomiase; Protozoose; Parasitose; Trouble de la nutritionMicronutrient; Immune system; Nutrition; Infection; T-Lymphocyte; Cellular immunity; Thymocyte; Extracellular matrix; Malnutrition; Mammalia; Chagas diseaseVertebrata; Trypanosomiasis; Protozoal disease; Parasitosis; Nutrition disorderMicronutriente; Sistema inmunitario; Nutrición; Infección; Linfocito T; Inmunidad celular; Timocito; Matriz extracelular; Malnutrición; Mammalia; Tripanosomiasis americanaINIST-1001.35400019340166022011-0087276 001605 Genetic diversity of the root-knot nematode Meloidogyne enterolobii and development of a SCAR marker for this guava-damaging speciesM. TiganoEmbrapa Recursos Genéticos e Biotecnologia, CP 0237270770-917 Brasilia, DFBRA1 aut.2 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.K. De SiqueiraEmbrapa Recursos Genéticos e Biotecnologia, CP 0237270770-917 Brasilia, DFBRA1 aut.2 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.P. Castagnone-SerenoINRA-UMR1301, UNSA, CNRS-UMR6243, Interactions Biotiques et Santé Végétale, 400 route des Chappes, BP16706903 Sophia AntipolisFRA3 aut.4 aut.K. MuletINRA-UMR1301, UNSA, CNRS-UMR6243, Interactions Biotiques et Santé Végétale, 400 route des Chappes, BP16706903 Sophia AntipolisFRA3 aut.4 aut.P. QueirozEmbrapa Recursos Genéticos e Biotecnologia, CP 0237270770-917 Brasilia, DFBRA1 aut.2 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.M. Dos SantosEmbrapa Recursos Genéticos e Biotecnologia, CP 0237270770-917 Brasilia, DFBRA1 aut.2 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.C. TeixeiraEmbrapa Recursos Genéticos e Biotecnologia, CP 0237270770-917 Brasilia, DFBRA1 aut.2 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.M. AlmeidaEmbrapa Recursos Genéticos e Biotecnologia, CP 0237270770-917 Brasilia, DFBRA1 aut.2 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.J. SilvaEmbrapa Recursos Genéticos e Biotecnologia, CP 0237270770-917 Brasilia, DFBRA1 aut.2 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.R. CarneiroEmbrapa Recursos Genéticos e Biotecnologia, CP 0237270770-917 Brasilia, DFBRA1 aut.2 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11-00873702010PASCAL 11-0087370 INISTPascal:11-00873700012920032-0862Plant pathol.Plant pathologyAmplified fragment length polymorphism markerDamagingDevelopmentDiagnosisGenetic diversityGuavaISSR markerMeloidogyneMicrosatellite DNAMolecular parameterPestPlant pathologyPsidium guajavaRandom amplified polymorphic DNA markerSequence characterized amplified region markerSpeciesDiversité génétiqueDéprédateurDéveloppementMarqueur SCAREndommagementEspèceMarqueur AFLPDiagnosticParamètre moléculaireMeloidogynePsidium guajavaGoyaveMarqueur RAPDPhytopathologieDNA microsatelliteMarqueur ISSR
The objectives of this work were to evaluate the genetic variability of Meloidogyne enterolobii by molecular markers, and develop species-specific molecular markers for application in detection. Sixteen M. enterolobii isolates from different geographical regions (Brazil and other countries) and hosts were used in this study. The identification and purification of the populations were carried out based on isoenzyme phenotype. The DNA amplification of the intergenic region (IGS) of the rDNA and of the region between the cytochrome oxidase subunit II (COII) and 16S rRNA genes (mtDNA) produced specific fragments of the expected size for this nematode, i.e. 780 and 705 bp, respectively. Intraspecific variability among the isolates was evaluated with three different neutral molecular markers: AFLP, ISSR and RAPD. The results showed a low level of diversity among the isolates tested, indicating that M. enterolobii is a genetically homogeneous root-knot nematode species. The RAPD method allowed the identification of a species-specific RAPD fragment for M. enterolobii. This fragment was cloned and sequenced, and from the sequence obtained, a set of primers was designed and tested. The amplification of a 520-bp-long fragment occurred only for the 16 isolates of M. enterolobii and not for the 10 other Meloidogyne species tested. In addition, positive detection was achieved in a single individual female, egg-mass and second stage juvenile of this nematode. This SCAR species-specific marker for M. enterolobii represents a new molecular tool to be used in the detection of this nematode from field samples and as a routine diagnostic test for quarantine devices.
0032-0862PLPAADPlant pathol.596Genetic diversity of the root-knot nematode Meloidogyne enterolobii and development of a SCAR marker for this guava-damaging speciesTIGANO (M.)DE SIQUEIRA (K.)CASTAGNONE-SERENO (P.)MULET (K.)QUEIROZ (P.)DOS SANTOS (M.)TEIXEIRA (C.)ALMEIDA (M.)SILVA (J.)CARNEIRO (R.)Embrapa Recursos Genéticos e Biotecnologia, CP 0237270770-917 Brasilia, DFBRA1 aut.2 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.INRA-UMR1301, UNSA, CNRS-UMR6243, Interactions Biotiques et Santé Végétale, 400 route des Chappes, BP16706903 Sophia AntipolisFRA3 aut.4 aut.1054-10612010ENGINIST74143540001934082800700000© 2011 INIST-CNRS. All rights reserved.1 p.1/411-0087370PAPlant pathologyGBRThe objectives of this work were to evaluate the genetic variability of Meloidogyne enterolobii by molecular markers, and develop species-specific molecular markers for application in detection. Sixteen M. enterolobii isolates from different geographical regions (Brazil and other countries) and hosts were used in this study. The identification and purification of the populations were carried out based on isoenzyme phenotype. The DNA amplification of the intergenic region (IGS) of the rDNA and of the region between the cytochrome oxidase subunit II (COII) and 16S rRNA genes (mtDNA) produced specific fragments of the expected size for this nematode, i.e. 780 and 705 bp, respectively. Intraspecific variability among the isolates was evaluated with three different neutral molecular markers: AFLP, ISSR and RAPD. The results showed a low level of diversity among the isolates tested, indicating that M. enterolobii is a genetically homogeneous root-knot nematode species. The RAPD method allowed the identification of a species-specific RAPD fragment for M. enterolobii. This fragment was cloned and sequenced, and from the sequence obtained, a set of primers was designed and tested. The amplification of a 520-bp-long fragment occurred only for the 16 isolates of M. enterolobii and not for the 10 other Meloidogyne species tested. In addition, positive detection was achieved in a single individual female, egg-mass and second stage juvenile of this nematode. This SCAR species-specific marker for M. enterolobii represents a new molecular tool to be used in the detection of this nematode from field samples and as a routine diagnostic test for quarantine devices.002A34Diversité génétique01Genetic diversity01Diversidad genética01Déprédateur02Pest02Plaga02Développement03Development03Desarrollo03Marqueur SCAR04Sequence characterized amplified region marker04Marcador SCAR04Endommagement05Damaging05Deterioración05Espèce06Species06Especie06Marqueur AFLP07Amplified fragment length polymorphism marker07Marcador AFLP07Diagnostic08Diagnosis08Diagnóstico08Paramètre moléculaire09Molecular parameter09Parámetro molecular09MeloidogyneNS10MeloidogyneNS10MeloidogyneNS10Psidium guajavaNS11Psidium guajavaNS11Psidium guajavaNS11Goyave15Guava15Guayaba15Marqueur RAPD28Random amplified polymorphic DNA marker28Marcador RAPD28Phytopathologie29Plant pathology29Fitopatología29DNA microsatellite30Microsatellite DNA30DNA microsatélite30Marqueur ISSRCD96ISSR markerCD96Marcador ISSRCD96NematodaNSNematodaNSNematodaNSNemathelminthiaNSNemathelminthiaNSNemathelminthiaNSHelminthaNSHelminthaNSHelminthaNSInvertebrataNSInvertebrataNSInvertebrataNSMyrtaceaeNSMyrtaceaeNSMyrtaceaeNSDicotyledonesNSDicotyledonesNSDicotyledonesNSAngiospermaeNSAngiospermaeNSAngiospermaeNSSpermatophytaNSSpermatophytaNSSpermatophytaNSArbre fruitier31Fruit tree31Arbol frutal31Plante fruitière32Fruit crop32Planta frutal32Diversité biologique33Biodiversity33Diversidad biológica33Marqueur moléculaire34Molecular marker34Marcador molecular34Fruit tropical50Tropical fruit50Fruta tropical50059OTOOTOPASCAL 11-0087370 INISTGenetic diversity of the root-knot nematode Meloidogyne enterolobii and development of a SCAR marker for this guava-damaging speciesTIGANO (M.); DE SIQUEIRA (K.); CASTAGNONE-SERENO (P.); MULET (K.); QUEIROZ (P.); DOS SANTOS (M.); TEIXEIRA (C.); ALMEIDA (M.); SILVA (J.); CARNEIRO (R.)Embrapa Recursos Genéticos e Biotecnologia, CP 02372/70770-917 Brasilia, DF/Brésil (1 aut., 2 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 10 aut.); INRA-UMR1301, UNSA, CNRS-UMR6243, Interactions Biotiques et Santé Végétale, 400 route des Chappes, BP167/06903 Sophia Antipolis/France (3 aut., 4 aut.)
Publication en série; Niveau analytique
Plant pathology; ISSN 0032-0862; Coden PLPAAD; Royaume-Uni; Da. 2010; Vol. 59; No. 6; Pp. 1054-1061; Bibl. 1 p.1/4AnglaisThe objectives of this work were to evaluate the genetic variability of Meloidogyne enterolobii by molecular markers, and develop species-specific molecular markers for application in detection. Sixteen M. enterolobii isolates from different geographical regions (Brazil and other countries) and hosts were used in this study. The identification and purification of the populations were carried out based on isoenzyme phenotype. The DNA amplification of the intergenic region (IGS) of the rDNA and of the region between the cytochrome oxidase subunit II (COII) and 16S rRNA genes (mtDNA) produced specific fragments of the expected size for this nematode, i.e. 780 and 705 bp, respectively. Intraspecific variability among the isolates was evaluated with three different neutral molecular markers: AFLP, ISSR and RAPD. The results showed a low level of diversity among the isolates tested, indicating that M. enterolobii is a genetically homogeneous root-knot nematode species. The RAPD method allowed the identification of a species-specific RAPD fragment for M. enterolobii. This fragment was cloned and sequenced, and from the sequence obtained, a set of primers was designed and tested. The amplification of a 520-bp-long fragment occurred only for the 16 isolates of M. enterolobii and not for the 10 other Meloidogyne species tested. In addition, positive detection was achieved in a single individual female, egg-mass and second stage juvenile of this nematode. This SCAR species-specific marker for M. enterolobii represents a new molecular tool to be used in the detection of this nematode from field samples and as a routine diagnostic test for quarantine devices.002A34Diversité génétique; Déprédateur; Développement; Marqueur SCAR; Endommagement; Espèce; Marqueur AFLP; Diagnostic; Paramètre moléculaire; Meloidogyne; Psidium guajava; Goyave; Marqueur RAPD; Phytopathologie; DNA microsatellite; Marqueur ISSRNematoda; Nemathelminthia; Helmintha; Invertebrata; Myrtaceae; Dicotyledones; Angiospermae; Spermatophyta; Arbre fruitier; Plante fruitière; Diversité biologique; Marqueur moléculaire; Fruit tropicalGenetic diversity; Pest; Development; Sequence characterized amplified region marker; Damaging; Species; Amplified fragment length polymorphism marker; Diagnosis; Molecular parameter; Meloidogyne; Psidium guajava; Guava; Random amplified polymorphic DNA marker; Plant pathology; Microsatellite DNA; ISSR markerNematoda; Nemathelminthia; Helmintha; Invertebrata; Myrtaceae; Dicotyledones; Angiospermae; Spermatophyta; Fruit tree; Fruit crop; Biodiversity; Molecular marker; Tropical fruitDiversidad genética; Plaga; Desarrollo; Marcador SCAR; Deterioración; Especie; Marcador AFLP; Diagnóstico; Parámetro molecular; Meloidogyne; Psidium guajava; Guayaba; Marcador RAPD; Fitopatología; DNA microsatélite; Marcador ISSRINIST-7414.35400019340828007011-0087370 001606 Factors at Admission Associated With Bleeding Risk in Medical Patients Findings From the IMPROVE InvestigatorsHervé DecoususINSERM, CIE3, the University Saint-Etienne, and CHU Saint-Etienne, Hôpital Nord, Service de Médecine Interne et ThérapeutiqueSaint-EtienneFRA1 aut.Victor F. TapsonDuke University Medical CenterDurham, NCGBR2 aut.Jean-François BergmannHôpital Lariboisiere Clinique Thérapeutique , University Paris DiderotParisFRA3 aut.Beng H. ChongSt. George Clinical School, University of New South WalesSydney, NSWAUS4 aut.James B. FroehlichDepartment of Vascular Medicine , University of Michigan Health SystemAnn Arbor, MIUSA5 aut.Ajay K. KakkarCentre for Surgical Sciences, Barts and The London, Queen Mary School of MedicineLondonGBR6 aut.Geno J. MerliJefferson Vascular Diseases Center, the Departments of Surgery and Medicine, Thomas Jefferson University HospitalPhiladelphia, PAUSA7 aut.Manuel MonrealServicio de Medicina Interna, Hospital Germans Trias i PujolBadalonaESP8 aut.Mashio NakamuraDepartment of Cardiology, Mie University Graduate School of MedicineTsu MieJPN9 aut.Ricardo PavanelloHospital do Coracao Clinica Medica São PauloSão PauloBRA10 aut.Mario PiniMedicina Interna II , Fidenza HospitalParmaITA11 aut.Franco PiovellaU.O. Angiologia , Fondazione IRCCS Policlinico San MatteoPaviaITA12 aut.Frederick A. SpencerHamilton Health Sciences General HospitalHamilton, ONCAN13 aut.14 aut.15 aut.Alex C. SpyropoulosHamilton Health Sciences General HospitalHamilton, ONCAN13 aut.14 aut.15 aut.Alexander G. G. TurpieHamilton Health Sciences General HospitalHamilton, ONCAN13 aut.14 aut.15 aut.Rainer B. ZotzHämostase-Institut DüsseldorfDüsseldorfDEU16 aut.Gordon FitzgeraldCenter for Outcomes Research University of Massachusetts Medical SchoolWorcester, MAUSA17 aut.18 aut.Frederick A. AndersonCenter for Outcomes Research University of Massachusetts Medical SchoolWorcester, MAUSA17 aut.18 aut.11-00902192011PASCAL 11-0090219 INISTPascal:11-00902190012910012-3692Chest : (Amer. Coll. Chest Phys.)Chest : (American College of Chest Physicians)AnesthesiaCardiologyCirculatory systemHemorrhageHumanPatientRiskRisk factorHémorragieFacteur risqueRisqueHommeMaladeAnesthésieAppareil circulatoireCardiologie
Background: Acutely ill, hospitalized medical patients are at risk of VTE. Despite guidelines for VTE prevention, prophylaxis use in these patients is still poor, possibly because of fear of bleeding risk. We used data from the International Medical Prevention Registry on Venous Thromboembolism (IMPROVE) to assess in-hospital bleeding incidence and to identify risk factors at admission associated with in-hospital bleeding risk in acutely ill medical patients. Methods: IMPROVE is a multinational, observational study that enrolled 15,156 medical patients. The in-hospital bleeding incidence was estimated by Kaplan-Meier analysis. A multiple regression model analysis was performed to identify risk factors at admission associated with bleeding. Results: The cumulative incidence of major and nonmajor in-hospital bleeding within 14 days of admission was 3.2%. Active gastroduodenal ulcer (OR, 4.15; 95% CI, 2.21-7.77), prior bleeding (OR, 3.64; 95% CI, 2.21-5.99), and low platelet count (OR, 3.37; 95% CI, 1.84-6.18) were the strongest independent risk factors at admission for bleeding. Other bleeding risk factors were increased age, hepatic or renal failure, ICU stay, central venous catheter, rheumatic disease, cancer, and male sex. Using these bleeding risk factors, a risk score was developed to estimate bleeding risk. Conclusions: We assessed the incidence of major and clinically relevant bleeding in a large population of hospitalized medical patients and identified risk factors at admission associated with in-hospital bleeding. This information may assist physicians in deciding whether to use mechanical or pharmacologic VTE prophylaxis.
0012-3692CHETBFChest : (Amer. Coll. Chest Phys.)1391Factors at Admission Associated With Bleeding Risk in Medical Patients Findings From the IMPROVE InvestigatorsDECOUSUS (Hervé)TAPSON (Victor F.)BERGMANN (Jean-François)CHONG (Beng H.)FROEHLICH (James B.)KAKKAR (Ajay K.)MERLI (Geno J.)MONREAL (Manuel)NAKAMURA (Mashio)PAVANELLO (Ricardo)PINI (Mario)PIOVELLA (Franco)SPENCER (Frederick A.)SPYROPOULOS (Alex C.)TURPIE (Alexander G. G.)ZOTZ (Rainer B.)FITZGERALD (Gordon)ANDERSON (Frederick A.)INSERM, CIE3, the University Saint-Etienne, and CHU Saint-Etienne, Hôpital Nord, Service de Médecine Interne et ThérapeutiqueSaint-EtienneFRA1 aut.Hôpital Lariboisiere Clinique Thérapeutique , University Paris DiderotParisFRA3 aut.Duke University Medical CenterDurham, NCGBR2 aut.St. George Clinical School, University of New South WalesSydney, NSWAUS4 aut.Department of Vascular Medicine , University of Michigan Health SystemAnn Arbor, MIUSA5 aut.Centre for Surgical Sciences, Barts and The London, Queen Mary School of MedicineLondonGBR6 aut.Jefferson Vascular Diseases Center, the Departments of Surgery and Medicine, Thomas Jefferson University HospitalPhiladelphia, PAUSA7 aut.Servicio de Medicina Interna, Hospital Germans Trias i PujolBadalonaESP8 aut.Department of Cardiology, Mie University Graduate School of MedicineTsu MieJPN9 aut.Hospital do Coracao Clinica Medica São PauloSão PauloBRA10 aut.Medicina Interna II , Fidenza HospitalParmaITA11 aut.U.O. Angiologia , Fondazione IRCCS Policlinico San MatteoPaviaITA12 aut.Hamilton Health Sciences General HospitalHamilton, ONCAN13 aut.14 aut.15 aut.Hämostase-Institut DüsseldorfDüsseldorfDEU16 aut.Center for Outcomes Research University of Massachusetts Medical SchoolWorcester, MAUSA17 aut.18 aut.IMPROVE InvestigatorsINC69-792011ENGINIST76273540001945972701300000© 2011 INIST-CNRS. All rights reserved.39 ref.11-0090219PAChest : (American College of Chest Physicians)USABackground: Acutely ill, hospitalized medical patients are at risk of VTE. Despite guidelines for VTE prevention, prophylaxis use in these patients is still poor, possibly because of fear of bleeding risk. We used data from the International Medical Prevention Registry on Venous Thromboembolism (IMPROVE) to assess in-hospital bleeding incidence and to identify risk factors at admission associated with in-hospital bleeding risk in acutely ill medical patients. Methods: IMPROVE is a multinational, observational study that enrolled 15,156 medical patients. The in-hospital bleeding incidence was estimated by Kaplan-Meier analysis. A multiple regression model analysis was performed to identify risk factors at admission associated with bleeding. Results: The cumulative incidence of major and nonmajor in-hospital bleeding within 14 days of admission was 3.2%. Active gastroduodenal ulcer (OR, 4.15; 95% CI, 2.21-7.77), prior bleeding (OR, 3.64; 95% CI, 2.21-5.99), and low platelet count (OR, 3.37; 95% CI, 1.84-6.18) were the strongest independent risk factors at admission for bleeding. Other bleeding risk factors were increased age, hepatic or renal failure, ICU stay, central venous catheter, rheumatic disease, cancer, and male sex. Using these bleeding risk factors, a risk score was developed to estimate bleeding risk. Conclusions: We assessed the incidence of major and clinically relevant bleeding in a large population of hospitalized medical patients and identified risk factors at admission associated with in-hospital bleeding. This information may assist physicians in deciding whether to use mechanical or pharmacologic VTE prophylaxis.002B11002B12Hémorragie01Hemorrhage01Hemorragia01Facteur risque09Risk factor09Factor riesgo09Risque10Risk10Riesgo10Homme11Human11Hombre11Malade12Patient12Enfermo12Anesthésie13Anesthesia13Anestesia13Appareil circulatoire14Circulatory system14Aparato circulatorio14Cardiologie15Cardiology15Cardiología15059OTOOTOPASCAL 11-0090219 INISTFactors at Admission Associated With Bleeding Risk in Medical Patients Findings From the IMPROVE InvestigatorsDECOUSUS (Hervé); TAPSON (Victor F.); BERGMANN (Jean-François); CHONG (Beng H.); FROEHLICH (James B.); KAKKAR (Ajay K.); MERLI (Geno J.); MONREAL (Manuel); NAKAMURA (Mashio); PAVANELLO (Ricardo); PINI (Mario); PIOVELLA (Franco); SPENCER (Frederick A.); SPYROPOULOS (Alex C.); TURPIE (Alexander G. G.); ZOTZ (Rainer B.); FITZGERALD (Gordon); ANDERSON (Frederick A.)INSERM, CIE3, the University Saint-Etienne, and CHU Saint-Etienne, Hôpital Nord, Service de Médecine Interne et Thérapeutique/Saint-Etienne/France (1 aut.); Hôpital Lariboisiere Clinique Thérapeutique , University Paris Diderot/Paris/France (3 aut.); Duke University Medical Center/Durham, NC/Royaume-Uni (2 aut.); St. George Clinical School, University of New South Wales/Sydney, NSW/Australie (4 aut.); Department of Vascular Medicine , University of Michigan Health System/Ann Arbor, MI/Etats-Unis (5 aut.); Centre for Surgical Sciences, Barts and The London, Queen Mary School of Medicine/London/Royaume-Uni (6 aut.); Jefferson Vascular Diseases Center, the Departments of Surgery and Medicine, Thomas Jefferson University Hospital/Philadelphia, PA/Etats-Unis (7 aut.); Servicio de Medicina Interna, Hospital Germans Trias i Pujol/Badalona/Espagne (8 aut.); Department of Cardiology, Mie University Graduate School of Medicine/Tsu Mie/Japon (9 aut.); Hospital do Coracao Clinica Medica São Paulo/São Paulo/Brésil (10 aut.); Medicina Interna II , Fidenza Hospital/Parma/Italie (11 aut.); U.O. Angiologia , Fondazione IRCCS Policlinico San Matteo/Pavia/Italie (12 aut.); Hamilton Health Sciences General Hospital/Hamilton, ON/Canada (13 aut., 14 aut., 15 aut.); Hämostase-Institut Düsseldorf/Düsseldorf/Allemagne (16 aut.); Center for Outcomes Research University of Massachusetts Medical School/Worcester, MA/Etats-Unis (17 aut., 18 aut.)
Publication en série; Niveau analytique
Chest : (American College of Chest Physicians); ISSN 0012-3692; Coden CHETBF; Etats-Unis; Da. 2011; Vol. 139; No. 1; Pp. 69-79; Bibl. 39 ref.AnglaisBackground: Acutely ill, hospitalized medical patients are at risk of VTE. Despite guidelines for VTE prevention, prophylaxis use in these patients is still poor, possibly because of fear of bleeding risk. We used data from the International Medical Prevention Registry on Venous Thromboembolism (IMPROVE) to assess in-hospital bleeding incidence and to identify risk factors at admission associated with in-hospital bleeding risk in acutely ill medical patients. Methods: IMPROVE is a multinational, observational study that enrolled 15,156 medical patients. The in-hospital bleeding incidence was estimated by Kaplan-Meier analysis. A multiple regression model analysis was performed to identify risk factors at admission associated with bleeding. Results: The cumulative incidence of major and nonmajor in-hospital bleeding within 14 days of admission was 3.2%. Active gastroduodenal ulcer (OR, 4.15; 95% CI, 2.21-7.77), prior bleeding (OR, 3.64; 95% CI, 2.21-5.99), and low platelet count (OR, 3.37; 95% CI, 1.84-6.18) were the strongest independent risk factors at admission for bleeding. Other bleeding risk factors were increased age, hepatic or renal failure, ICU stay, central venous catheter, rheumatic disease, cancer, and male sex. Using these bleeding risk factors, a risk score was developed to estimate bleeding risk. Conclusions: We assessed the incidence of major and clinically relevant bleeding in a large population of hospitalized medical patients and identified risk factors at admission associated with in-hospital bleeding. This information may assist physicians in deciding whether to use mechanical or pharmacologic VTE prophylaxis.002B11; 002B12Hémorragie; Facteur risque; Risque; Homme; Malade; Anesthésie; Appareil circulatoire; CardiologieHemorrhage; Risk factor; Risk; Human; Patient; Anesthesia; Circulatory system; CardiologyHemorragia; Factor riesgo; Riesgo; Hombre; Enfermo; Anestesia; Aparato circulatorio; CardiologíaINIST-7627.35400019459727013011-0090219 001607 Application of the biorefinery concept to produce <sub>L</sub>-lactic acid from the soybean vinasse at laboratory and pilot scaleSusan G. KarpBioprocess Engineering and Biotechnology Division. Federal University of Paraná, P.O. Box 19 011Zip Code 81531-990 CuritibaBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.10 aut.Adriana H. IgashiyamaBioprocess Engineering and Biotechnology Division. Federal University of Paraná, P.O. Box 19 011Zip Code 81531-990 CuritibaBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.10 aut.Paula F. SiqueiraBioprocess Engineering and Biotechnology Division. Federal University of Paraná, P.O. Box 19 011Zip Code 81531-990 CuritibaBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.10 aut.J Lio C. CarvalhoBioprocess Engineering and Biotechnology Division. Federal University of Paraná, P.O. Box 19 011Zip Code 81531-990 CuritibaBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.10 aut.Luciana P. S. VandenbergheBioprocess Engineering and Biotechnology Division. Federal University of Paraná, P.O. Box 19 011Zip Code 81531-990 CuritibaBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.10 aut.Vanete Thomaz-SoccolBioprocess Engineering and Biotechnology Division. Federal University of Paraná, P.O. Box 19 011Zip Code 81531-990 CuritibaBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.10 aut.Jefferson CoralBioprocess Engineering and Biotechnology Division. Federal University of Paraná, P.O. Box 19 011Zip Code 81531-990 CuritibaBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.10 aut.Jean-Luc TholozanLaboratory of Microbiology, IRD, University of Provence/University of the MediterraneanMarseilleFRA8 aut.Ashok PandeyBiotechnology Division, National Institute for Interdisciplinary Science and Technology, CSIRThiruvananthapuram 695 019, KeralaIND9 aut.Carlos R. SoccolBioprocess Engineering and Biotechnology Division. Federal University of Paraná, P.O. Box 19 011Zip Code 81531-990 CuritibaBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.10 aut.11-00906812011PASCAL 11-0090681 INISTPascal:11-00906810012900960-8524Bioresour. technol.Bioresource technologyBiorefineryGlycine maxLactic acidMolassesPilot plant scaleSoybeanVinasseBioraffinerieVinasseEchelle piloteMélasseGlycine maxAcide lactiqueSoja
Lactic acid is a product that finds several applications in food, cosmetic, pharmaceutical and chemical industries. The main objective of this work was the development of a bioprocess to produce L(+)-lactic acid using soybean vinasse as substrate. Among ten strains, Lactobacillus agilis LPB 56 was selected for fermentation, due to its ability to metabolize the complex oligosaccharides. Fermentation was conducted without need for supplementary inorganic nitrogen sources or yeast extract. Kinetic and yield parameters determined at laboratory scale were 0.864 and 0.0162 for VP/S and YX/S, 0.0145 g/L h (rx), 1.32 g/L h (rs) and 1.13 g/L h (rp). The use of vinasse enriched with soybean molasses provided higher lactic acid concentration (138 g/L), the best proportion of inoculum being 25% (v/v). After scale-up to a pilot plant, kinetic and yield parameters were 0.849 and 0.0353 for YP/S and YX/S, 0.0278 g/L h (rx), 0.915 g/L h (rs) and 0.863 g/L h (rp).
0960-8524Bioresour. technol.1022Application of the biorefinery concept to produce L-lactic acid from the soybean vinasse at laboratory and pilot scaleKARP (Susan G.)IGASHIYAMA (Adriana H.)SIQUEIRA (Paula F.)CARVALHO (Júlio C.)VANDENBERGHE (Luciana P. S.)THOMAZ-SOCCOL (Vanete)CORAL (Jefferson)THOLOZAN (Jean-Luc)PANDEY (Ashok)SOCCOL (Carlos R.)Bioprocess Engineering and Biotechnology Division. Federal University of Paraná, P.O. Box 19 011Zip Code 81531-990 CuritibaBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.10 aut.Laboratory of Microbiology, IRD, University of Provence/University of the MediterraneanMarseilleFRA8 aut.Biotechnology Division, National Institute for Interdisciplinary Science and Technology, CSIRThiruvananthapuram 695 019, KeralaIND9 aut.1765-17722011ENGINIST187693540001935887918600000© 2011 INIST-CNRS. All rights reserved.1/2 p.11-0090681PABioresource technologyGBRLactic acid is a product that finds several applications in food, cosmetic, pharmaceutical and chemical industries. The main objective of this work was the development of a bioprocess to produce L(+)-lactic acid using soybean vinasse as substrate. Among ten strains, Lactobacillus agilis LPB 56 was selected for fermentation, due to its ability to metabolize the complex oligosaccharides. Fermentation was conducted without need for supplementary inorganic nitrogen sources or yeast extract. Kinetic and yield parameters determined at laboratory scale were 0.864 and 0.0162 for VP/S and YX/S, 0.0145 g/L h (rx), 1.32 g/L h (rs) and 1.13 g/L h (rp). The use of vinasse enriched with soybean molasses provided higher lactic acid concentration (138 g/L), the best proportion of inoculum being 25% (v/v). After scale-up to a pilot plant, kinetic and yield parameters were 0.849 and 0.0353 for YP/S and YX/S, 0.0278 g/L h (rx), 0.915 g/L h (rs) and 0.863 g/L h (rp).002A35FBioraffinerie01Biorefinery01Biorefinería01Vinasse02Vinasse02Vinaza02Echelle pilote03Pilot plant scale03Escala piloto03Mélasse04Molasses04Melaza04Glycine maxNS10Glycine maxNS10Glycine maxNS10Acide lactiqueNK15Lactic acidNK15Láctico ácidoNK15Soja16Soybean16Soya16LeguminosaeNSLeguminosaeNSLeguminosaeNSDicotyledonesNSDicotyledonesNSDicotyledonesNSAngiospermaeNSAngiospermaeNSAngiospermaeNSSpermatophytaNSSpermatophytaNSSpermatophytaNSLégumineuse grain31Grain legume31Leguminosa grano31059OTOOTOPASCAL 11-0090681 INISTApplication of the biorefinery concept to produce L-lactic acid from the soybean vinasse at laboratory and pilot scaleKARP (Susan G.); IGASHIYAMA (Adriana H.); SIQUEIRA (Paula F.); CARVALHO (Júlio C.); VANDENBERGHE (Luciana P. S.); THOMAZ-SOCCOL (Vanete); CORAL (Jefferson); THOLOZAN (Jean-Luc); PANDEY (Ashok); SOCCOL (Carlos R.)Bioprocess Engineering and Biotechnology Division. Federal University of Paraná, P.O. Box 19 011/Zip Code 81531-990 Curitiba/Brésil (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 10 aut.); Laboratory of Microbiology, IRD, University of Provence/University of the Mediterranean/Marseille/France (8 aut.); Biotechnology Division, National Institute for Interdisciplinary Science and Technology, CSIR/Thiruvananthapuram 695 019, Kerala/Inde (9 aut.)
Publication en série; Niveau analytique
Bioresource technology; ISSN 0960-8524; Royaume-Uni; Da. 2011; Vol. 102; No. 2; Pp. 1765-1772; Bibl. 1/2 p.AnglaisLactic acid is a product that finds several applications in food, cosmetic, pharmaceutical and chemical industries. The main objective of this work was the development of a bioprocess to produce L(+)-lactic acid using soybean vinasse as substrate. Among ten strains, Lactobacillus agilis LPB 56 was selected for fermentation, due to its ability to metabolize the complex oligosaccharides. Fermentation was conducted without need for supplementary inorganic nitrogen sources or yeast extract. Kinetic and yield parameters determined at laboratory scale were 0.864 and 0.0162 for VP/S and YX/S, 0.0145 g/L h (rx), 1.32 g/L h (rs) and 1.13 g/L h (rp). The use of vinasse enriched with soybean molasses provided higher lactic acid concentration (138 g/L), the best proportion of inoculum being 25% (v/v). After scale-up to a pilot plant, kinetic and yield parameters were 0.849 and 0.0353 for YP/S and YX/S, 0.0278 g/L h (rx), 0.915 g/L h (rs) and 0.863 g/L h (rp).002A35FBioraffinerie; Vinasse; Echelle pilote; Mélasse; Glycine max; Acide lactique; SojaLeguminosae; Dicotyledones; Angiospermae; Spermatophyta; Légumineuse grainBiorefinery; Vinasse; Pilot plant scale; Molasses; Glycine max; Lactic acid; SoybeanLeguminosae; Dicotyledones; Angiospermae; Spermatophyta; Grain legumeBiorefinería; Vinaza; Escala piloto; Melaza; Glycine max; Láctico ácido; SoyaINIST-18769.35400019358879186011-0090681 001608 DISCOVERY OF A NEW AM CVn SYSTEM WITH THE KEPLER SATELLITEG. FontaineDépartement de Physique, Université de Montréal, Succ. Centre-Ville, C.P. 6128Montréal, QC H3C 3J7CAN1 aut.2 aut.5 aut.10 aut.P. BrassardDépartement de Physique, Université de Montréal, Succ. Centre-Ville, C.P. 6128Montréal, QC H3C 3J7CAN1 aut.2 aut.5 aut.10 aut.E. M. GreenSteward Observatory, University of Arizona, 933 North Cherry AvenueTucson, AZ 85721USA3 aut.6 aut.11 aut.12 aut.S. CharpinetLaboratoire d'Astrophysiyue de Toulouse-Tarbes, Université de Toulouse, CNRS, 14 av. E. Belin31400 ToulouseFRA4 aut.13 aut.P. DufourDépartement de Physique, Université de Montréal, Succ. Centre-Ville, C.P. 6128Montréal, QC H3C 3J7CAN1 aut.2 aut.5 aut.10 aut.I. HubenySteward Observatory, University of Arizona, 933 North Cherry AvenueTucson, AZ 85721USA3 aut.6 aut.11 aut.12 aut.D. SteeghsDepartment of Astrophysics, University of WarwickCoventry CV4 7ALGBR7 aut.20 aut.C. AertsInstituut voor Sterrenkunde, Katholieke Universiteit Leuven, Celestijnenlaan 200D3001 LeuvenBEL8 aut.14 aut.15 aut.26 aut.Department of Astrophysics, IMAPP, Radboud University Nijmegen, P.O. Box9010 GL NijmegenNLD8 aut.S. K. RandallEuropean Southern Observatory, Karl-Schwarzschild-Str. 285748 Garching bei MünchenDEU9 aut.P. BergeronDépartement de Physique, Université de Montréal, Succ. Centre-Ville, C.P. 6128Montréal, QC H3C 3J7CAN1 aut.2 aut.5 aut.10 aut.B. GuvenenSteward Observatory, University of Arizona, 933 North Cherry AvenueTucson, AZ 85721USA3 aut.6 aut.11 aut.12 aut.C. J. O MalleySteward Observatory, University of Arizona, 933 North Cherry AvenueTucson, AZ 85721USA3 aut.6 aut.11 aut.12 aut.V. Van GrootelLaboratoire d'Astrophysiyue de Toulouse-Tarbes, Université de Toulouse, CNRS, 14 av. E. Belin31400 ToulouseFRA4 aut.13 aut.R. H. StensenInstituut voor Sterrenkunde, Katholieke Universiteit Leuven, Celestijnenlaan 200D3001 LeuvenBEL8 aut.14 aut.15 aut.26 aut.S. BloemenInstituut voor Sterrenkunde, Katholieke Universiteit Leuven, Celestijnenlaan 200D3001 LeuvenBEL8 aut.14 aut.15 aut.26 aut.R. SilvottiINAF-Osservatorio Astronomico di Torino, Strada dell'Osservatorio 2010025 Pino TorineseITA16 aut.S. B. HowellNational Optical Astronomy ObservatoryTucson, AZ 85719USA17 aut.A. BaranKrakow Pedagogical University, ul. Podchorazych 230-084 KrakowPOL18 aut.S. O. KeplerInstituto de Fisica, Universidade Federal do Rio Grande do SulPorto Alegre, RSBRA19 aut.T. R. MarshDepartment of Astrophysics, University of WarwickCoventry CV4 7ALGBR7 aut.20 aut.M. H. MontgomeryDepartment of Astronomy, University of Texas at AustinAustin, TX 78712USA21 aut.25 aut.R. OreiroInstituto de Astrofisica de Andalucía, Glorieta de la Astronomía s/n18008 GranadaESP22 aut.J. ProvencalDepartment of Physics and Astronomy, University of DelawareNewark, DE 19716USA23 aut.J. TeltingNordic Optical Telescope38700 Santa Cruz de La PalmaESP24 aut.D. E. WingetDepartment of Astronomy, University of Texas at AustinAustin, TX 78712USA21 aut.25 aut.W. ZimaInstituut voor Sterrenkunde, Katholieke Universiteit Leuven, Celestijnenlaan 200D3001 LeuvenBEL8 aut.14 aut.15 aut.26 aut.J. Christensen-DalsgaardDepartment of Physics and Astronomy, Aarhus University8000, AarhusDNK27 aut.28 aut.H. KjeldsenDepartment of Physics and Astronomy, Aarhus University8000, AarhusDNK27 aut.28 aut.11-00920732011PASCAL 11-0092073 INISTPascal:11-00920730012890004-637XAstrophys. j.The Astrophysical journalAccretion disksAm starsClose binary starsFourier analysisInterstellar absorptionKepler satelliteLight curvesLuminosityMass transferOptical spectrometryPeriodicityPhotometryPulse shapeQuasi periodic variationSpectroscopical observationWave frontWhite dwarf starsSatellite KeplerPhotométrieSpectrométrie optiqueEtoile AmDisque accrétionAbsorption interstellaireObservation spectroscopiqueTransfert masseCourbe lumièrePériodicitéLuminositéForme impulsionFront ondeAnalyse FourierVariation quasi périodiqueBinaire serréeNaine blanche
We report the discovery of a new AM CVn system on the basis of broadband photometry obtained with the Kepler satellite supplemented by ground-based optical spectroscopy. Initially retained on Kepler target lists as a potential compact pulsator, the blue object SDSS J190817.07+394036.4 (KIC 004547333) has turned out to be a high-state AM CVn star showing the He-dominated spectrum of its accretion disk significantly reddened by interstellar absorption. We constructed new grids of NLTE synthetic spectra for accretion disks in order to analyze our spectroscopic observations. From this analysis, we infer preliminary estimates of the rate of mass transfer, the inclination angle of the disk, and the distance to the system. The AM CVn nature of the system is also evident in the Kepler light curve, from which we extracted 11 secure periodicities. The luminosity variations are dominated by a basic periodicity of 938.507 s, likely to correspond to a superhump modulation. The light curve folded on the period of 938.507 s exhibits a pulse shape that is very similar to the superhump wavefront seen in AM CVn itself, which is a high-state system and the prototype of the class. Our Fourier analysis also suggests the likely presence of a quasi-periodic oscillation similar to those already observed in some high-state AM CVn systems. Furthermore, some very low-frequency, low-amplitude aperiodic photometric activity is likely present, which is in line with what is expected in accreting binary systems. Inspired by previous work, we further looked for and found some intriguing numerical relationships between the 11 secure detected frequencies, in the sense that we can account for all of them in terms of only three basic clocks. This is further evidence in favor of the AM CVn nature of the system.
0004-637XASJOABAstrophys. j.7262p. 1DISCOVERY OF A NEW AM CVn SYSTEM WITH THE KEPLER SATELLITEFONTAINE (G.)BRASSARD (P.)GREEN (E. M.)CHARPINET (S.)DUFOUR (P.)HUBENY (I.)STEEGHS (D.)AERTS (C.)RANDALL (S. K.)BERGERON (P.)GUVENEN (B.)O'MALLEY (C. J.)VAN GROOTEL (V.)ØSTENSEN (R. H.)BLOEMEN (S.)SILVOTTI (R.)HOWELL (S. B.)BARAN (A.)KEPLER (S. O.)MARSH (T. R.)MONTGOMERY (M. H.)OREIRO (R.)PROVENCAL (J.)TELTING (J.)WINGET (D. E.)ZIMA (W.)CHRISTENSEN-DALSGAARD (J.)KJELDSEN (H.)Département de Physique, Université de Montréal, Succ. Centre-Ville, C.P. 6128Montréal, QC H3C 3J7CAN1 aut.2 aut.5 aut.10 aut.Steward Observatory, University of Arizona, 933 North Cherry AvenueTucson, AZ 85721USA3 aut.6 aut.11 aut.12 aut.Laboratoire d'Astrophysiyue de Toulouse-Tarbes, Université de Toulouse, CNRS, 14 av. E. Belin31400 ToulouseFRA4 aut.13 aut.Department of Astrophysics, University of WarwickCoventry CV4 7ALGBR7 aut.20 aut.Instituut voor Sterrenkunde, Katholieke Universiteit Leuven, Celestijnenlaan 200D3001 LeuvenBEL8 aut.14 aut.15 aut.26 aut.Department of Astrophysics, IMAPP, Radboud University Nijmegen, P.O. Box9010 GL NijmegenNLD8 aut.European Southern Observatory, Karl-Schwarzschild-Str. 285748 Garching bei MünchenDEU9 aut.INAF-Osservatorio Astronomico di Torino, Strada dell'Osservatorio 2010025 Pino TorineseITA16 aut.National Optical Astronomy ObservatoryTucson, AZ 85719USA17 aut.Krakow Pedagogical University, ul. Podchorazych 230-084 KrakowPOL18 aut.Instituto de Fisica, Universidade Federal do Rio Grande do SulPorto Alegre, RSBRA19 aut.Department of Astronomy, University of Texas at AustinAustin, TX 78712USA21 aut.25 aut.Instituto de Astrofisica de Andalucía, Glorieta de la Astronomía s/n18008 GranadaESP22 aut.Department of Physics and Astronomy, University of DelawareNewark, DE 19716USA23 aut.Nordic Optical Telescope38700 Santa Cruz de La PalmaESP24 aut.Department of Physics and Astronomy, Aarhus University8000, AarhusDNK27 aut.28 aut.72692.1-72692.112011ENGINIST5123540001935453003600000© 2011 INIST-CNRS. All rights reserved.1/4 p.11-0092073PAThe Astrophysical journalGBRWe report the discovery of a new AM CVn system on the basis of broadband photometry obtained with the Kepler satellite supplemented by ground-based optical spectroscopy. Initially retained on Kepler target lists as a potential compact pulsator, the blue object SDSS J190817.07+394036.4 (KIC 004547333) has turned out to be a high-state AM CVn star showing the He-dominated spectrum of its accretion disk significantly reddened by interstellar absorption. We constructed new grids of NLTE synthetic spectra for accretion disks in order to analyze our spectroscopic observations. From this analysis, we infer preliminary estimates of the rate of mass transfer, the inclination angle of the disk, and the distance to the system. The AM CVn nature of the system is also evident in the Kepler light curve, from which we extracted 11 secure periodicities. The luminosity variations are dominated by a basic periodicity of 938.507 s, likely to correspond to a superhump modulation. The light curve folded on the period of 938.507 s exhibits a pulse shape that is very similar to the superhump wavefront seen in AM CVn itself, which is a high-state system and the prototype of the class. Our Fourier analysis also suggests the likely presence of a quasi-periodic oscillation similar to those already observed in some high-state AM CVn systems. Furthermore, some very low-frequency, low-amplitude aperiodic photometric activity is likely present, which is in line with what is expected in accreting binary systems. Inspired by previous work, we further looked for and found some intriguing numerical relationships between the 11 secure detected frequencies, in the sense that we can account for all of them in terms of only three basic clocks. This is further evidence in favor of the AM CVn nature of the system.001E03Satellite Kepler26Kepler satellite26Satélite Kepler26Photométrie27Photometry27Spectrométrie optique28Optical spectrometry28Espectrometría óptica28Etoile Am29Am stars29Disque accrétion30Accretion disks30Absorption interstellaire31Interstellar absorption31Absorción interestelar31Observation spectroscopique32Spectroscopical observation32Observación espectroscópica32Transfert masse33Mass transfer33Courbe lumière34Light curves34Périodicité35Periodicity35Periodicidad35Luminosité36Luminosity36Forme impulsion37Pulse shape37Forma impulsión37Front onde38Wave front38Analyse Fourier39Fourier analysis39Variation quasi périodique40Quasi periodic variation40Variación semiperiódica40Binaire serrée41Close binary stars41Naine blanche42White dwarf stars42059OTOOTOPASCAL 11-0092073 INISTDISCOVERY OF A NEW AM CVn SYSTEM WITH THE KEPLER SATELLITEFONTAINE (G.); BRASSARD (P.); GREEN (E. M.); CHARPINET (S.); DUFOUR (P.); HUBENY (I.); STEEGHS (D.); AERTS (C.); RANDALL (S. K.); BERGERON (P.); GUVENEN (B.); O'MALLEY (C. J.); VAN GROOTEL (V.); ØSTENSEN (R. H.); BLOEMEN (S.); SILVOTTI (R.); HOWELL (S. B.); BARAN (A.); KEPLER (S. O.); MARSH (T. R.); MONTGOMERY (M. H.); OREIRO (R.); PROVENCAL (J.); TELTING (J.); WINGET (D. E.); ZIMA (W.); CHRISTENSEN-DALSGAARD (J.); KJELDSEN (H.)Département de Physique, Université de Montréal, Succ. Centre-Ville, C.P. 6128/Montréal, QC H3C 3J7/Canada (1 aut., 2 aut., 5 aut., 10 aut.); Steward Observatory, University of Arizona, 933 North Cherry Avenue/Tucson, AZ 85721/Etats-Unis (3 aut., 6 aut., 11 aut., 12 aut.); Laboratoire d'Astrophysiyue de Toulouse-Tarbes, Université de Toulouse, CNRS, 14 av. E. Belin/31400 Toulouse/France (4 aut., 13 aut.); Department of Astrophysics, University of Warwick/Coventry CV4 7AL/Royaume-Uni (7 aut., 20 aut.); Instituut voor Sterrenkunde, Katholieke Universiteit Leuven, Celestijnenlaan 200D/3001 Leuven/Belgique (8 aut., 14 aut., 15 aut., 26 aut.); Department of Astrophysics, IMAPP, Radboud University Nijmegen, P.O. Box/9010 GL Nijmegen/Pays-Bas (8 aut.); European Southern Observatory, Karl-Schwarzschild-Str. 2/85748 Garching bei München/Allemagne (9 aut.); INAF-Osservatorio Astronomico di Torino, Strada dell'Osservatorio 20/10025 Pino Torinese/Italie (16 aut.); National Optical Astronomy Observatory/Tucson, AZ 85719/Etats-Unis (17 aut.); Krakow Pedagogical University, ul. Podchorazych 2/30-084 Krakow/Pologne (18 aut.); Instituto de Fisica, Universidade Federal do Rio Grande do Sul/Porto Alegre, RS/Brésil (19 aut.); Department of Astronomy, University of Texas at Austin/Austin, TX 78712/Etats-Unis (21 aut., 25 aut.); Instituto de Astrofisica de Andalucía, Glorieta de la Astronomía s/n/18008 Granada/Espagne (22 aut.); Department of Physics and Astronomy, University of Delaware/Newark, DE 19716/Etats-Unis (23 aut.); Nordic Optical Telescope/38700 Santa Cruz de La Palma/Espagne (24 aut.); Department of Physics and Astronomy, Aarhus University/8000, Aarhus/Danemark (27 aut., 28 aut.)
Publication en série; Niveau analytique
The Astrophysical journal; ISSN 0004-637X; Coden ASJOAB; Royaume-Uni; Da. 2011; Vol. 726; No. 2 p. 1; 72692.1-72692.11; Bibl. 1/4 p.AnglaisWe report the discovery of a new AM CVn system on the basis of broadband photometry obtained with the Kepler satellite supplemented by ground-based optical spectroscopy. Initially retained on Kepler target lists as a potential compact pulsator, the blue object SDSS J190817.07+394036.4 (KIC 004547333) has turned out to be a high-state AM CVn star showing the He-dominated spectrum of its accretion disk significantly reddened by interstellar absorption. We constructed new grids of NLTE synthetic spectra for accretion disks in order to analyze our spectroscopic observations. From this analysis, we infer preliminary estimates of the rate of mass transfer, the inclination angle of the disk, and the distance to the system. The AM CVn nature of the system is also evident in the Kepler light curve, from which we extracted 11 secure periodicities. The luminosity variations are dominated by a basic periodicity of 938.507 s, likely to correspond to a superhump modulation. The light curve folded on the period of 938.507 s exhibits a pulse shape that is very similar to the superhump wavefront seen in AM CVn itself, which is a high-state system and the prototype of the class. Our Fourier analysis also suggests the likely presence of a quasi-periodic oscillation similar to those already observed in some high-state AM CVn systems. Furthermore, some very low-frequency, low-amplitude aperiodic photometric activity is likely present, which is in line with what is expected in accreting binary systems. Inspired by previous work, we further looked for and found some intriguing numerical relationships between the 11 secure detected frequencies, in the sense that we can account for all of them in terms of only three basic clocks. This is further evidence in favor of the AM CVn nature of the system.001E03Satellite Kepler; Photométrie; Spectrométrie optique; Etoile Am; Disque accrétion; Absorption interstellaire; Observation spectroscopique; Transfert masse; Courbe lumière; Périodicité; Luminosité; Forme impulsion; Front onde; Analyse Fourier; Variation quasi périodique; Binaire serrée; Naine blancheKepler satellite; Photometry; Optical spectrometry; Am stars; Accretion disks; Interstellar absorption; Spectroscopical observation; Mass transfer; Light curves; Periodicity; Luminosity; Pulse shape; Wave front; Fourier analysis; Quasi periodic variation; Close binary stars; White dwarf starsSatélite Kepler; Espectrometría óptica; Absorción interestelar; Observación espectroscópica; Periodicidad; Forma impulsión; Variación semiperiódicaINIST-512.35400019354530036011-0092073 001609 On the analysis of notched concrete beams: From measurement with digital image correlation to identification with boundary element method of a cohesive modelM. D. C. FerreiraDepartamento de Engenharia de Estruturas, Escola de Engenharia de São Carlos, Universidade de São Paulo, Av. Trabalhador São-Carlense. 400CEP 13566-590, São Carlos, SPBRA1 aut.2 aut.W. S. VenturiniDepartamento de Engenharia de Estruturas, Escola de Engenharia de São Carlos, Universidade de São Paulo, Av. Trabalhador São-Carlense. 400CEP 13566-590, São Carlos, SPBRA1 aut.2 aut.F. HildLMT Cachan, ENS Cachan/CNRS/UPMC/PRES UniverSud Paris, 61 avenue du Président Wilson94235 CachanFRA3 aut.11-00927472011PASCAL 11-0092747 INISTPascal:11-00927470012880013-7944Eng. fract. mech.Engineering fracture mechanicsBending testBoundary element methodCohesive endConcrete constructionConfidenceCorrelationDeformation modulusDigital imageElastic constantImage processingInverse problemModelingNotchParameter estimationRuptureSurface crackSystem identificationTractionUncertain systemYoung modulusCorrélationFissure superficielleConstante élasticitéModule déformationModule YoungRuptureEntailleExtrémité cohésiveConstruction bétonTractionConfianceTraitement imageMéthode élément frontièreModélisationProblème inverseIdentification systèmeEstimation paramètreImage numériqueEssai flexionSystème incertain
A way of coupling digital image correlation (to measure displacement fields) and boundary element method (to compute displacements and tractions along a crack surface) is presented herein. It allows for the identification of Young's modulus and fracture parameters associated with a cohesive model. This procedure is illustrated to analyze the latter for an ordinary concrete in a three-point bend test on a notched beam. In view of measurement uncertainties, the results are deemed trustworthy thanks to the fact that numerous measurement points are accessible and used as entries to the identification procedure.
0013-7944EFMEAHEng. fract. mech.781On the analysis of notched concrete beams: From measurement with digital image correlation to identification with boundary element method of a cohesive modelFERREIRA (M. D. C.)VENTURINI (W. S.)HILD (F.)Departamento de Engenharia de Estruturas, Escola de Engenharia de São Carlos, Universidade de São Paulo, Av. Trabalhador São-Carlense. 400CEP 13566-590, São Carlos, SPBRA1 aut.2 aut.LMT Cachan, ENS Cachan/CNRS/UPMC/PRES UniverSud Paris, 61 avenue du Président Wilson94235 CachanFRA3 aut.71-842011ENGINIST139553540001943217900600000© 2011 INIST-CNRS. All rights reserved.45 ref.11-0092747PAEngineering fracture mechanicsGBRA way of coupling digital image correlation (to measure displacement fields) and boundary element method (to compute displacements and tractions along a crack surface) is presented herein. It allows for the identification of Young's modulus and fracture parameters associated with a cohesive model. This procedure is illustrated to analyze the latter for an ordinary concrete in a three-point bend test on a notched beam. In view of measurement uncertainties, the results are deemed trustworthy thanks to the fact that numerous measurement points are accessible and used as entries to the identification procedure.001D14H02D001B40F30N001D02C03001B40F30C295Corrélation06Correlation06Correlación06Fissure superficielle07Surface crack07Fisura superficial07Constante élasticité08Elastic constant08Constante elasticidad08Module déformation09Deformation modulus09Módulo deformación09Module Young10Young modulus10Módulo Young10Rupture11Rupture11Ruptura11Entaille15Notch15Entalla15Extrémité cohésive16Cohesive end16Extremidad cohesiva16Construction béton17Concrete construction17Construcción de hormigon17Traction18Traction18Tracción18Confiance19Confidence19Confianza19Traitement image23Image processing23Procesamiento imagen23Méthode élément frontière24Boundary element method24Método elemento frontera24Modélisation25Modeling25Modelización25Problème inverse26Inverse problem26Problema inverso26Identification système27System identification27Identificación sistema27Estimation paramètre28Parameter estimation28Estimación parámetro28Image numérique33Digital image33Imagen numérica33Essai flexion34Bending test34Ensayo flexion34Système incertain35Uncertain system35Sistema incierto35059OTOOTOPASCAL 11-0092747 INISTOn the analysis of notched concrete beams: From measurement with digital image correlation to identification with boundary element method of a cohesive modelFERREIRA (M. D. C.); VENTURINI (W. S.); HILD (F.)Departamento de Engenharia de Estruturas, Escola de Engenharia de São Carlos, Universidade de São Paulo, Av. Trabalhador São-Carlense. 400/CEP 13566-590, São Carlos, SP/Brésil (1 aut., 2 aut.); LMT Cachan, ENS Cachan/CNRS/UPMC/PRES UniverSud Paris, 61 avenue du Président Wilson/94235 Cachan/France (3 aut.)
Publication en série; Niveau analytique
Engineering fracture mechanics; ISSN 0013-7944; Coden EFMEAH; Royaume-Uni; Da. 2011; Vol. 78; No. 1; Pp. 71-84; Bibl. 45 ref.AnglaisA way of coupling digital image correlation (to measure displacement fields) and boundary element method (to compute displacements and tractions along a crack surface) is presented herein. It allows for the identification of Young's modulus and fracture parameters associated with a cohesive model. This procedure is illustrated to analyze the latter for an ordinary concrete in a three-point bend test on a notched beam. In view of measurement uncertainties, the results are deemed trustworthy thanks to the fact that numerous measurement points are accessible and used as entries to the identification procedure.001D14H02D; 001B40F30N; 001D02C03; 001B40F30C; 295Corrélation; Fissure superficielle; Constante élasticité; Module déformation; Module Young; Rupture; Entaille; Extrémité cohésive; Construction béton; Traction; Confiance; Traitement image; Méthode élément frontière; Modélisation; Problème inverse; Identification système; Estimation paramètre; Image numérique; Essai flexion; Système incertainCorrelation; Surface crack; Elastic constant; Deformation modulus; Young modulus; Rupture; Notch; Cohesive end; Concrete construction; Traction; Confidence; Image processing; Boundary element method; Modeling; Inverse problem; System identification; Parameter estimation; Digital image; Bending test; Uncertain systemCorrelación; Fisura superficial; Constante elasticidad; Módulo deformación; Módulo Young; Ruptura; Entalla; Extremidad cohesiva; Construcción de hormigon; Tracción; Confianza; Procesamiento imagen; Método elemento frontera; Modelización; Problema inverso; Identificación sistema; Estimación parámetro; Imagen numérica; Ensayo flexion; Sistema inciertoINIST-13955.35400019432179006011-0092747 001610 Advanced Bifurcation Systems' mother-daughter platformMehran KhorsandiCedars-Sinai Medical CenterLos Angeles, CAUSA1 aut.4 aut.6 aut.7 aut.Alex AbizaidInstituto Dante Pazzanese de CardiologiaSao PauloBRA2 aut.5 aut.Sameer DaniLifecare Institute of Life Sciences and ResearchAhmedabadIND3 aut.Henry BourangCedars-Sinai Medical CenterLos Angeles, CAUSA1 aut.4 aut.6 aut.7 aut.Ricardo CostaInstituto Dante Pazzanese de CardiologiaSao PauloBRA2 aut.5 aut.Saibal KarCedars-Sinai Medical CenterLos Angeles, CAUSA1 aut.4 aut.6 aut.7 aut.Raj MakkarCedars-Sinai Medical CenterLos Angeles, CAUSA1 aut.4 aut.6 aut.7 aut.11-00930062010PASCAL 11-0093006 INISTPascal:11-00930060012871774-024XEuroInterventionEuroInterventionBifurcationMotherSystemBifurcationSystèmeMère1774-024XEuroIntervention6SUPJAdvanced Bifurcation Systems' mother-daughter platformCoronary Bifurcation StentingKHORSANDI (Mehran)ABIZAID (Alex)DANI (Sameer)BOURANG (Henry)COSTA (Ricardo)KAR (Saibal)MAKKAR (Raj)LEFEVRE (Thierry)ed.LOUVARD (YVES)ed.VAN GEUNS (Robert-Jan)ed.Cedars-Sinai Medical CenterLos Angeles, CAUSA1 aut.4 aut.6 aut.7 aut.Instituto Dante Pazzanese de CardiologiaSao PauloBRA2 aut.5 aut.Lifecare Institute of Life Sciences and ResearchAhmedabadIND3 aut.ICPS91300 MassyFRA2 aut.Interventional Cardiology, Erasmus MCRotterdamNLD3 aut.Institut Cardiovasculaire Paris Sud91300 MassyFRA1 aut.J165-J1682010ENGINIST276593540001918932402700000© 2011 INIST-CNRS. All rights reserved.11-0093006PAEuroInterventionFRA002B25Bifurcation09Bifurcation09Bifurcación09Système10System10Sistema10Mère11Mother11Madre11059OTOOTOPASCAL 11-0093006 INISTAdvanced Bifurcation Systems' mother-daughter platformKHORSANDI (Mehran); ABIZAID (Alex); DANI (Sameer); BOURANG (Henry); COSTA (Ricardo); KAR (Saibal); MAKKAR (Raj); LEFEVRE (Thierry); LOUVARD (YVES); VAN GEUNS (Robert-Jan)Cedars-Sinai Medical Center/Los Angeles, CA/Etats-Unis (1 aut., 4 aut., 6 aut., 7 aut.); Instituto Dante Pazzanese de Cardiologia/Sao Paulo/Brésil (2 aut., 5 aut.); Lifecare Institute of Life Sciences and Research/Ahmedabad/Inde (3 aut.); ICPS/91300 Massy/France (2 aut.); Interventional Cardiology, Erasmus MC/Rotterdam/Pays-Bas (3 aut.); Institut Cardiovasculaire Paris Sud/91300 Massy/France (1 aut.)
Publication en série; Niveau analytique
EuroIntervention; ISSN 1774-024X; France; Da. 2010; Vol. 6; No. SUPJ; J165-J168Anglais002B25Bifurcation; Système; MèreBifurcation; System; MotherBifurcación; Sistema; MadreINIST-27659.35400019189324027011-0093006 001611 Left main stenting: do we need another study?Pedro A. LemosHeart Institute (Incor), University of São Paulo Medical School (USP)Sao PauloBRA1 aut.3 aut.4 aut.Pieter KappeteinErasmus University Medical CenterRotterdamNLD2 aut.Roberto Kalil-FilhoHeart Institute (Incor), University of São Paulo Medical School (USP)Sao PauloBRA1 aut.3 aut.4 aut.Fabio B. JateneHeart Institute (Incor), University of São Paulo Medical School (USP)Sao PauloBRA1 aut.3 aut.4 aut.11-00930072010PASCAL 11-0093007 INISTPascal:11-00930070012861774-024XEuroInterventionEuroInterventionInstrumental dilatationInstrumentation therapyLeftStentGaucheDilatation instrumentaleStentTraitement instrumental1774-024XEuroIntervention6SUPJLeft main stenting: do we need another study?Coronary Bifurcation StentingLEMOS (Pedro A.)KAPPETEIN (Pieter)KALIL-FILHO (Roberto)JATENE (Fabio B.)LEFEVRE (Thierry)ed.LOUVARD (YVES)ed.VAN GEUNS (Robert-Jan)ed.Heart Institute (Incor), University of São Paulo Medical School (USP)Sao PauloBRA1 aut.3 aut.4 aut.Erasmus University Medical CenterRotterdamNLD2 aut.ICPS91300 MassyFRA2 aut.Interventional Cardiology, Erasmus MCRotterdamNLD3 aut.Institut Cardiovasculaire Paris Sud91300 MassyFRA1 aut.J118-J1222010ENGINIST276593540001918932401700000© 2011 INIST-CNRS. All rights reserved.35 ref.11-0093007PAEuroInterventionFRA002B25002B26EGauche09Left09Izquierdo09Dilatation instrumentale10Instrumental dilatation10Dilatación instrumental10Stent11Stent11Stent11Traitement instrumental78Instrumentation therapy78Tratamiento instrumental78059OTOOTOPASCAL 11-0093007 INISTLeft main stenting: do we need another study?LEMOS (Pedro A.); KAPPETEIN (Pieter); KALIL-FILHO (Roberto); JATENE (Fabio B.); LEFEVRE (Thierry); LOUVARD (YVES); VAN GEUNS (Robert-Jan)Heart Institute (Incor), University of São Paulo Medical School (USP)/Sao Paulo/Brésil (1 aut., 3 aut., 4 aut.); Erasmus University Medical Center/Rotterdam/Pays-Bas (2 aut.); ICPS/91300 Massy/France (2 aut.); Interventional Cardiology, Erasmus MC/Rotterdam/Pays-Bas (3 aut.); Institut Cardiovasculaire Paris Sud/91300 Massy/France (1 aut.)
Publication en série; Niveau analytique
EuroIntervention; ISSN 1774-024X; France; Da. 2010; Vol. 6; No. SUPJ; J118-J122; Bibl. 35 ref.Anglais002B25; 002B26EGauche; Dilatation instrumentale; Stent; Traitement instrumentalLeft; Instrumental dilatation; Stent; Instrumentation therapyIzquierdo; Dilatación instrumental; Stent; Tratamiento instrumentalINIST-27659.35400019189324017011-0093007 001612 FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC<sup>3</sup> programThierry PoynardAPHP-UPMC Liver CenterParisFRA1 aut.2 aut.Mona MunteanuAPHP-UPMC Liver CenterParisFRA1 aut.2 aut.Massimo ColomboRirst Division of Gastroenterology, Fondazione IRCCS Maggiore Hospital, University of MilanMilanITA3 aut.Jordi BruixCentro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas, Liver Unit, Hospital Clinic, University of BarcelonaBarcelonaESP4 aut.Eugene SchiffUniversity of Miami School of MedicineMiami, FLUSA5 aut.Ruben TergHospital Municipal de Gastroenterologia Dr. Bonorino UdaondoCapital FederalARG6 aut.Steven FlammNorthwestern UniversityChicago, ILUSA7 aut.Ricardo Moreno-OteroHospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas (Instituto de Salud Carlos III)MadridESP8 aut.Flair CarrilhoDepartment of Gastroenterology, University of São Paulo School of MedicineSão PauloBRA9 aut.Warren SchmidtUniversity of Iowa Hospitals and ClinicsIowa City, IAUSA10 aut.Thomas BergCharité, Campus Virchow Klinikum, Universitätsmedizin BerlinDEU11 aut.Thomas McgarrityMilton S. Hershey Medical CenterHershey, PAUSA12 aut.E. Jenny HeathcoteUniversity Health NetworkToronto, ONCAN13 aut.Fernando GoncalesDepartment of Medical Clinical, Faculty of Medical Sciences, University of CampinasCampinasBRA14 aut.Moises DiagoHospital General Universitario de ValenciaValenciaESP15 aut.Antonio CraxiGI and Liver Unit, DIBIMIS, University of PalermoPalermoITA16 aut.Marcelo SilvaHospital Universitario AustralPilarARG17 aut.Navdeep BoparaiSchering-Plough Research InstituteKenilworth, NJUSA18 aut.19 aut.20 aut.21 aut.22 aut.Louis GriffelSchering-Plough Research InstituteKenilworth, NJUSA18 aut.19 aut.20 aut.21 aut.22 aut.Margaret BurroughsSchering-Plough Research InstituteKenilworth, NJUSA18 aut.19 aut.20 aut.21 aut.22 aut.Clifford BrassSchering-Plough Research InstituteKenilworth, NJUSA18 aut.19 aut.20 aut.21 aut.22 aut.Janice AlbrechtSchering-Plough Research InstituteKenilworth, NJUSA18 aut.19 aut.20 aut.21 aut.22 aut.11-00957722011PASCAL 11-0095772 INISTPascal:11-00957720012850168-8278J. hepatol.Journal of hepatologyAlpha interferonAntiviralBiological markerCirrhosisFailureFibrosisGastroenterologyHumanInterferon alfaPredictive factorRibavirinTreatmentViral hepatitis CHépatite virale CCirrhoseInterféron alphaFacteur prédictifHommeRibavirineFibroseMarqueur biologiqueTraitementEchecGastroentérologieAntiviralInterféron alfa
Background & Aims: EPIC-3 is a prospective, international study that has demonstrated the efficacy of PEG-IFN alfa-2b plus weight-based ribavirin in patients with chronic hepatitis C and significant fibrosis who previously failed any interferon-alfa/ ribavirin therapy. The aim of the present study was to assess FibroTest (FT), a validated non-invasive marker of fibrosis in treatment-naive patients, as a possible alternative to biopsy as the baseline predictor of subsequent early virologic (EVR) and sustained virologic response (SVR) in previously treated patients. Methods: Of 2312 patients enrolled, 1459 had an available baseline FT, biopsy, and complete data. Uni- (UV) and multi-variable (MV) analyses were performed using FT and biopsy. Results: Baseline characteristics were similar as in the overall population; METAVIR stage: 28% F2, 29% F3, and 43% F4, previous relapsers 29%, previous PEG-IFN regimen 41%, high baseline viral load (BVL) 64%. 506 patients (35%) had undetectable HCV-RNA at TW12 (TW12neg), with 58% achieving SVR. The accuracy of FT was similar to that in naive patients: AUROC curve for the diagnosis of F4 vs F2 = 0.80 (p <0.00001). Five baseline factors were associated (p <0.001) with SVR in UV and MV analyses (odds ratio: UV/ MV): fibrosis stage estimated using FT (4.5/5.9) or biopsy (1.5/ 1.6), genotype 2/3 (4.5/5.1), BVL (1.5/1.3), prior relapse (1.6/1.6), previous treatment with non-PEG-IFN (2.6/2.0). These same factors were associated (p≤0.001) with EVR. Among patients TW12neg, two independent factors remained highly predictive of SVR by MV analysis (p ≤0.001): genotype 2/3 (odds ratio = 2.9), fibrosis estimated with FT (4.3) or by biopsy (1.5). Conclusions: FibroTest at baseline is a possible non-invasive alternative to biopsy for the prediction of EVR at 12 weeks and SVR, in patients with previous failures and advanced fibrosis, retreated with PEG-IFN alfa-2b and ribavirin.
0168-8278JOHEECJ. hepatol.542FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC3 programPOYNARD (Thierry)MUNTEANU (Mona)COLOMBO (Massimo)BRUIX (Jordi)SCHIFF (Eugene)TERG (Ruben)FLAMM (Steven)MORENO-OTERO (Ricardo)CARRILHO (Flair)SCHMIDT (Warren)BERG (Thomas)MCGARRITY (Thomas)HEATHCOTE (E. Jenny)GONCALES (Fernando)DIAGO (Moises)CRAXI (Antonio)SILVA (Marcelo)BOPARAI (Navdeep)GRIFFEL (Louis)BURROUGHS (Margaret)BRASS (Clifford)ALBRECHT (Janice)APHP-UPMC Liver CenterParisFRA1 aut.2 aut.Rirst Division of Gastroenterology, Fondazione IRCCS Maggiore Hospital, University of MilanMilanITA3 aut.Centro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas, Liver Unit, Hospital Clinic, University of BarcelonaBarcelonaESP4 aut.University of Miami School of MedicineMiami, FLUSA5 aut.Hospital Municipal de Gastroenterologia Dr. Bonorino UdaondoCapital FederalARG6 aut.Northwestern UniversityChicago, ILUSA7 aut.Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas (Instituto de Salud Carlos III)MadridESP8 aut.Department of Gastroenterology, University of São Paulo School of MedicineSão PauloBRA9 aut.University of Iowa Hospitals and ClinicsIowa City, IAUSA10 aut.Charité, Campus Virchow Klinikum, Universitätsmedizin BerlinDEU11 aut.Milton S. Hershey Medical CenterHershey, PAUSA12 aut.University Health NetworkToronto, ONCAN13 aut.Department of Medical Clinical, Faculty of Medical Sciences, University of CampinasCampinasBRA14 aut.Hospital General Universitario de ValenciaValenciaESP15 aut.GI and Liver Unit, DIBIMIS, University of PalermoPalermoITA16 aut.Hospital Universitario AustralPilarARG17 aut.Schering-Plough Research InstituteKenilworth, NJUSA18 aut.19 aut.20 aut.21 aut.22 aut.227-2352011ENGINIST207063540001935274000800000© 2011 INIST-CNRS. All rights reserved.36 ref.11-0095772PAJournal of hepatologyGBRBackground & Aims: EPIC-3 is a prospective, international study that has demonstrated the efficacy of PEG-IFN alfa-2b plus weight-based ribavirin in patients with chronic hepatitis C and significant fibrosis who previously failed any interferon-alfa/ ribavirin therapy. The aim of the present study was to assess FibroTest (FT), a validated non-invasive marker of fibrosis in treatment-naive patients, as a possible alternative to biopsy as the baseline predictor of subsequent early virologic (EVR) and sustained virologic response (SVR) in previously treated patients. Methods: Of 2312 patients enrolled, 1459 had an available baseline FT, biopsy, and complete data. Uni- (UV) and multi-variable (MV) analyses were performed using FT and biopsy. Results: Baseline characteristics were similar as in the overall population; METAVIR stage: 28% F2, 29% F3, and 43% F4, previous relapsers 29%, previous PEG-IFN regimen 41%, high baseline viral load (BVL) 64%. 506 patients (35%) had undetectable HCV-RNA at TW12 (TW12neg), with 58% achieving SVR. The accuracy of FT was similar to that in naive patients: AUROC curve for the diagnosis of F4 vs F2 = 0.80 (p <0.00001). Five baseline factors were associated (p <0.001) with SVR in UV and MV analyses (odds ratio: UV/ MV): fibrosis stage estimated using FT (4.5/5.9) or biopsy (1.5/ 1.6), genotype 2/3 (4.5/5.1), BVL (1.5/1.3), prior relapse (1.6/1.6), previous treatment with non-PEG-IFN (2.6/2.0). These same factors were associated (p≤0.001) with EVR. Among patients TW12neg, two independent factors remained highly predictive of SVR by MV analysis (p ≤0.001): genotype 2/3 (odds ratio = 2.9), fibrosis estimated with FT (4.3) or by biopsy (1.5). Conclusions: FibroTest at baseline is a possible non-invasive alternative to biopsy for the prediction of EVR at 12 weeks and SVR, in patients with previous failures and advanced fibrosis, retreated with PEG-IFN alfa-2b and ribavirin.002B13C03002B05C02G002B02S05Hépatite virale C01Viral hepatitis C01Hepatítis virica C01Cirrhose02Cirrhosis02Cirrosis02Interféron alphaFR04Alpha interferonFR04Interferón alfaFR04Facteur prédictif07Predictive factor07Factor predictivo07Homme08Human08Hombre08RibavirineNKFR09RibavirinNKFR09RibavirinaNKFR09Fibrose13Fibrosis13Fibrosis13Marqueur biologique14Biological marker14Marcador biológico14Traitement15Treatment15Tratamiento15Echec16Failure16Fracaso16Gastroentérologie17Gastroenterology17Gastroenterología17Antiviral30Antiviral30Antiviral30Interféron alfaCD96Interferon alfaCD96Interferón alfaCD96ViroseViral diseaseVirosisInfectionInfectionInfecciónPathologie de l'appareil digestif37Digestive diseases37Aparato digestivo patología37Pathologie du foie38Hepatic disease38Hígado patología38Analogue de nucléoside40Nucleoside analog40Análogo nucleósido40059OTOOTOPASCAL 11-0095772 INISTFibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC3 programPOYNARD (Thierry); MUNTEANU (Mona); COLOMBO (Massimo); BRUIX (Jordi); SCHIFF (Eugene); TERG (Ruben); FLAMM (Steven); MORENO-OTERO (Ricardo); CARRILHO (Flair); SCHMIDT (Warren); BERG (Thomas); MCGARRITY (Thomas); HEATHCOTE (E. Jenny); GONCALES (Fernando); DIAGO (Moises); CRAXI (Antonio); SILVA (Marcelo); BOPARAI (Navdeep); GRIFFEL (Louis); BURROUGHS (Margaret); BRASS (Clifford); ALBRECHT (Janice)APHP-UPMC Liver Center/Paris/France (1 aut., 2 aut.); Rirst Division of Gastroenterology, Fondazione IRCCS Maggiore Hospital, University of Milan/Milan/Italie (3 aut.); Centro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas, Liver Unit, Hospital Clinic, University of Barcelona/Barcelona/Espagne (4 aut.); University of Miami School of Medicine/Miami, FL/Etats-Unis (5 aut.); Hospital Municipal de Gastroenterologia Dr. Bonorino Udaondo/Capital Federal/Argentine (6 aut.); Northwestern University/Chicago, IL/Etats-Unis (7 aut.); Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas (Instituto de Salud Carlos III)/Madrid/Espagne (8 aut.); Department of Gastroenterology, University of São Paulo School of Medicine/São Paulo/Brésil (9 aut.); University of Iowa Hospitals and Clinics/Iowa City, IA/Etats-Unis (10 aut.); Charité, Campus Virchow Klinikum, Universitätsmedizin Berlin/Allemagne (11 aut.); Milton S. Hershey Medical Center/Hershey, PA/Etats-Unis (12 aut.); University Health Network/Toronto, ON/Canada (13 aut.); Department of Medical Clinical, Faculty of Medical Sciences, University of Campinas/Campinas/Brésil (14 aut.); Hospital General Universitario de Valencia/Valencia/Espagne (15 aut.); GI and Liver Unit, DIBIMIS, University of Palermo/Palermo/Italie (16 aut.); Hospital Universitario Austral/Pilar/Argentine (17 aut.); Schering-Plough Research Institute/Kenilworth, NJ/Etats-Unis (18 aut., 19 aut., 20 aut., 21 aut., 22 aut.)
Publication en série; Niveau analytique
Journal of hepatology; ISSN 0168-8278; Coden JOHEEC; Royaume-Uni; Da. 2011; Vol. 54; No. 2; Pp. 227-235; Bibl. 36 ref.AnglaisBackground & Aims: EPIC-3 is a prospective, international study that has demonstrated the efficacy of PEG-IFN alfa-2b plus weight-based ribavirin in patients with chronic hepatitis C and significant fibrosis who previously failed any interferon-alfa/ ribavirin therapy. The aim of the present study was to assess FibroTest (FT), a validated non-invasive marker of fibrosis in treatment-naive patients, as a possible alternative to biopsy as the baseline predictor of subsequent early virologic (EVR) and sustained virologic response (SVR) in previously treated patients. Methods: Of 2312 patients enrolled, 1459 had an available baseline FT, biopsy, and complete data. Uni- (UV) and multi-variable (MV) analyses were performed using FT and biopsy. Results: Baseline characteristics were similar as in the overall population; METAVIR stage: 28% F2, 29% F3, and 43% F4, previous relapsers 29%, previous PEG-IFN regimen 41%, high baseline viral load (BVL) 64%. 506 patients (35%) had undetectable HCV-RNA at TW12 (TW12neg), with 58% achieving SVR. The accuracy of FT was similar to that in naive patients: AUROC curve for the diagnosis of F4 vs F2 = 0.80 (p <0.00001). Five baseline factors were associated (p <0.001) with SVR in UV and MV analyses (odds ratio: UV/ MV): fibrosis stage estimated using FT (4.5/5.9) or biopsy (1.5/ 1.6), genotype 2/3 (4.5/5.1), BVL (1.5/1.3), prior relapse (1.6/1.6), previous treatment with non-PEG-IFN (2.6/2.0). These same factors were associated (p≤0.001) with EVR. Among patients TW12neg, two independent factors remained highly predictive of SVR by MV analysis (p ≤0.001): genotype 2/3 (odds ratio = 2.9), fibrosis estimated with FT (4.3) or by biopsy (1.5). Conclusions: FibroTest at baseline is a possible non-invasive alternative to biopsy for the prediction of EVR at 12 weeks and SVR, in patients with previous failures and advanced fibrosis, retreated with PEG-IFN alfa-2b and ribavirin.002B13C03; 002B05C02G; 002B02S05Hépatite virale C; Cirrhose; Interféron alpha; Facteur prédictif; Homme; Ribavirine; Fibrose; Marqueur biologique; Traitement; Echec; Gastroentérologie; Antiviral; Interféron alfaVirose; Infection; Pathologie de l'appareil digestif; Pathologie du foie; Analogue de nucléosideViral hepatitis C; Cirrhosis; Alpha interferon; Predictive factor; Human; Ribavirin; Fibrosis; Biological marker; Treatment; Failure; Gastroenterology; Antiviral; Interferon alfaViral disease; Infection; Digestive diseases; Hepatic disease; Nucleoside analogHepatítis virica C; Cirrosis; Interferón alfa; Factor predictivo; Hombre; Ribavirina; Fibrosis; Marcador biológico; Tratamiento; Fracaso; Gastroenterología; Antiviral; Interferón alfaINIST-20706.35400019352740008011-0095772 001613 DNA-based methods for eriophyoid mite studies: review, critical aspects, prospects and challengesMaria NavajasINRA, UMR CBGP (INRA/IRD/CIRAD/Montpellier SupAgro), Campus International de Baillarguet, CS 3001634988 Montferrier sur LezFRA1 aut.Denise NaviaLaboratory of Plant Quarantine, Embrapa Recursos Genéticos e Biotecnologia, Postal Code 02372, 70770-900 Brasilia, DFBRA2 aut.11-00963472010PASCAL 11-0096347 INISTPascal:11-00963470012840168-8162Exp. appl. acarol.Experimental & applied acarologyAcariCritical studyDNAInvasive speciesMethodMolecular systematicsPest managementPhylogenySpecific identificationDNAMéthodeEtude critiqueSystématique moléculairePhylogenèseIdentification spécifiqueLutte antidéprédateurEspèce envahissanteAcari
Besides their potential for species identification, DNA-based methods are also routinely used for addressing ecological, evolutionary, phylogenetic and genetic questions to study several groups of Acari. However, in contrast to other plant-feeding mites and despite the economical relevance of many species of Eriophyoidea, very few scientists have dared so far to use DNA methods for the study of this group of mites; their very small size certainly has influenced this. In this review we examine the main techniques that have been used to study eriophyoid mites and discuss the results from the literature where DNA methods have provided significant advances to address several essential questions of the eriophyoid biology, e.g., to clarify suspect synonymies, to test hypothesis of cryptic spe- cies, to examine the occurrence of biotypes, especially in relation to virus ability or host- plant associations, to understand colonization patterns of invasive species, and for uses as biological control agents against invasive plants. We discuss these questions which might be related to agricultural issues, together with more fundamental aspects as the revision of the phylogeny of the Eriophyoidea. We discuss on the advantages as well as limitations of the most commonly used genetic markers and emphasize prospects and challenges of new molecular approaches. Much is now expected from molecular techniques in many fields of biology and for virtually all taxa. Eriophyoids should not be the exception.
0168-8162EAACEMExp. appl. acarol.511-3DNA-based methods for eriophyoid mite studies: review, critical aspects, prospects and challengesEriophyoid Mites: Progress and PrognosesNAVAJAS (Maria)NAVIA (Denise)UECKERMANN (Eddie A.)ed.INRA, UMR CBGP (INRA/IRD/CIRAD/Montpellier SupAgro), Campus International de Baillarguet, CS 3001634988 Montferrier sur LezFRA1 aut.Laboratory of Plant Quarantine, Embrapa Recursos Genéticos e Biotecnologia, Postal Code 02372, 70770-900 Brasilia, DFBRA2 aut.ARC Plant Protection Res. Inst., Private Bag X134Pretoria 0001ZAF1 aut.257-2712010ENGINIST208663540001806169801200000© 2011 INIST-CNRS. All rights reserved.2 p.1/411-0096347PAExperimental & applied acarologyDEUBesides their potential for species identification, DNA-based methods are also routinely used for addressing ecological, evolutionary, phylogenetic and genetic questions to study several groups of Acari. However, in contrast to other plant-feeding mites and despite the economical relevance of many species of Eriophyoidea, very few scientists have dared so far to use DNA methods for the study of this group of mites; their very small size certainly has influenced this. In this review we examine the main techniques that have been used to study eriophyoid mites and discuss the results from the literature where DNA methods have provided significant advances to address several essential questions of the eriophyoid biology, e.g., to clarify suspect synonymies, to test hypothesis of cryptic spe- cies, to examine the occurrence of biotypes, especially in relation to virus ability or host- plant associations, to understand colonization patterns of invasive species, and for uses as biological control agents against invasive plants. We discuss these questions which might be related to agricultural issues, together with more fundamental aspects as the revision of the phylogeny of the Eriophyoidea. We discuss on the advantages as well as limitations of the most commonly used genetic markers and emphasize prospects and challenges of new molecular approaches. Much is now expected from molecular techniques in many fields of biology and for virtually all taxa. Eriophyoids should not be the exception.002A34I01DNA01DNA01DNA01Méthode02Method02Método02Etude critique03Critical study03Estudio crítico03Systématique moléculaire04Molecular systematics04Taxonomía molecular04Phylogenèse05Phylogeny05Filogénesis05Identification spécifique06Specific identification06Identificación especifica06Lutte antidéprédateur07Pest management07Manejo de plagas07Espèce envahissante08Invasive species08Especie invasora08AcariNS55AcariNS55AcariNS55ArachnidaNSArachnidaNSArachnidaNSArthropodaNSArthropodaNSArthropodaNSInvertebrataNSInvertebrataNSInvertebrataNS059PASCAL 11-0096347 INISTDNA-based methods for eriophyoid mite studies: review, critical aspects, prospects and challengesNAVAJAS (Maria); NAVIA (Denise); UECKERMANN (Eddie A.)INRA, UMR CBGP (INRA/IRD/CIRAD/Montpellier SupAgro), Campus International de Baillarguet, CS 30016/34988 Montferrier sur Lez/France (1 aut.); Laboratory of Plant Quarantine, Embrapa Recursos Genéticos e Biotecnologia, Postal Code 02372, 70/770-900 Brasilia, DF/Brésil (2 aut.); ARC Plant Protection Res. Inst., Private Bag X134/Pretoria 0001/Afrique du Sud (1 aut.)
Publication en série; Niveau analytique
Experimental & applied acarology; ISSN 0168-8162; Coden EAACEM; Allemagne; Da. 2010; Vol. 51; No. 1-3; Pp. 257-271; Bibl. 2 p.1/4AnglaisBesides their potential for species identification, DNA-based methods are also routinely used for addressing ecological, evolutionary, phylogenetic and genetic questions to study several groups of Acari. However, in contrast to other plant-feeding mites and despite the economical relevance of many species of Eriophyoidea, very few scientists have dared so far to use DNA methods for the study of this group of mites; their very small size certainly has influenced this. In this review we examine the main techniques that have been used to study eriophyoid mites and discuss the results from the literature where DNA methods have provided significant advances to address several essential questions of the eriophyoid biology, e.g., to clarify suspect synonymies, to test hypothesis of cryptic spe- cies, to examine the occurrence of biotypes, especially in relation to virus ability or host- plant associations, to understand colonization patterns of invasive species, and for uses as biological control agents against invasive plants. We discuss these questions which might be related to agricultural issues, together with more fundamental aspects as the revision of the phylogeny of the Eriophyoidea. We discuss on the advantages as well as limitations of the most commonly used genetic markers and emphasize prospects and challenges of new molecular approaches. Much is now expected from molecular techniques in many fields of biology and for virtually all taxa. Eriophyoids should not be the exception.002A34I01DNA; Méthode; Etude critique; Systématique moléculaire; Phylogenèse; Identification spécifique; Lutte antidéprédateur; Espèce envahissante; AcariArachnida; Arthropoda; InvertebrataDNA; Method; Critical study; Molecular systematics; Phylogeny; Specific identification; Pest management; Invasive species; AcariArachnida; Arthropoda; InvertebrataDNA; Método; Estudio crítico; Taxonomía molecular; Filogénesis; Identificación especifica; Manejo de plagas; Especie invasora; AcariINIST-20866.35400018061698012011-0096347 001614 DESIGN OF A PARTICIPATORY DECISION MAKING AGENT ARCHITECTURE BASED ON ARGUMENTATION AND INFLUENCE FUNCTION - APPLICATION TO A SERIOUS GAME ABOUT BIODIVERSITY CONSERVATIONAlessandro SordoniLaboratoire d'Informatique de Paris 6 (LIP6), Université Pierre et Marie Curie - CNRSParisFRA1 aut.2 aut.Jean-Pierre BriotLaboratoire d'Informatique de Paris 6 (LIP6), Université Pierre et Marie Curie - CNRSParisFRA1 aut.2 aut.Computer Science Department, Pontificia Universidade Católica (PUC-Rio)Rio de Janeiro, RJBRA2 aut.4 aut.Isabelle AlvarezLaboratoire d'Ingénierie pour les Systèmes Complexes (LISC), CEMAGREFAubièreFRA3 aut.Eurico VasconcelosComputer Science Department, Pontificia Universidade Católica (PUC-Rio)Rio de Janeiro, RJBRA2 aut.4 aut.Marta De Azevedo IrvingEICOS Program, Universidade Federal do Rio de Janeiro (UFRJ)Rio de Janeiro, RJBRA5 aut.6 aut.Gustavo MeloEICOS Program, Universidade Federal do Rio de Janeiro (UFRJ)Rio de Janeiro, RJBRA5 aut.6 aut.11-00970492010PASCAL 11-0097049 INISTPascal:11-00970490012830399-0559RAIRO, Rech. opér.RAIRO. Recherche opérationnelleArgumentationArtificial intelligenceBargainingCommunity participationDecision makingDecision support systemEconometricsFirm managementFirm strategyInfluence functionMultiagent systemNational parkPreferenceRole playingSoftware agentsSystem architectureTourismPrise de décisionSystème aide décisionSystème multiagentIntelligence artificielleArchitecture systèmeArgumentationFonction influenceParc nationalTourismeGestion entrepriseStratégie entrepriseJeu rôleParticipation communautaireNégociationPréférenceEconométrie.Agent logiciel
This paper addresses an ongoing experience in the design of an artificial agent taking decisions and combining them with the decisions taken by human agents. The context is a serious game research project, aimed at computer-based support for participatory management of protected areas (and more specifically national parks) in order to promote biodiversity conservation and social inclusion. Its objective is to help various stakeholders (e.g., environmentalist, tourism operator) to collectively understand conflict dynamics and explore negotiation strategies for the management of parks. In this paper, after introducing the design of our serious game, named SimParc, we will describe the architecture of the decision making agent playing the role of the park manager. In the game, the park manager makes final decisions based on its own analysis and also on the votes of the stakeholders. It includes two modules: 1) individual decision - based on a model of argumentation, which also provides a basis to justify and explain the decision; 2) participatory decision - to take into account the preferences/votes from the stakeholders.
0399-0559RSROD3RAIRO, Rech. opér.444DESIGN OF A PARTICIPATORY DECISION MAKING AGENT ARCHITECTURE BASED ON ARGUMENTATION AND INFLUENCE FUNCTION - APPLICATION TO A SERIOUS GAME ABOUT BIODIVERSITY CONSERVATIONCOGnitive systems with Interactive SensorsSORDONI (Alessandro)BRIOT (Jean-Pierre)ALVAREZ (Isabelle)VASCONCELOS (Eurico)DE AZEVEDO IRVING (Marta)MELO (Gustavo)BARBARESCO (Frédéric)limin.Laboratoire d'Informatique de Paris 6 (LIP6), Université Pierre et Marie Curie - CNRSParisFRA1 aut.2 aut.Computer Science Department, Pontificia Universidade Católica (PUC-Rio)Rio de Janeiro, RJBRA2 aut.4 aut.Laboratoire d'Ingénierie pour les Systèmes Complexes (LISC), CEMAGREFAubièreFRA3 aut.EICOS Program, Universidade Federal do Rio de Janeiro (UFRJ)Rio de Janeiro, RJBRA5 aut.6 aut.269-2832010ENGfreINIST9323C3540001935564400100000© 2011 INIST-CNRS. All rights reserved.13 ref.11-0097049PARAIRO. Recherche opérationnelleFRAThis paper addresses an ongoing experience in the design of an artificial agent taking decisions and combining them with the decisions taken by human agents. The context is a serious game research project, aimed at computer-based support for participatory management of protected areas (and more specifically national parks) in order to promote biodiversity conservation and social inclusion. Its objective is to help various stakeholders (e.g., environmentalist, tourism operator) to collectively understand conflict dynamics and explore negotiation strategies for the management of parks. In this paper, after introducing the design of our serious game, named SimParc, we will describe the architecture of the decision making agent playing the role of the park manager. In the game, the park manager makes final decisions based on its own analysis and also on the votes of the stakeholders. It includes two modules: 1) individual decision - based on a model of argumentation, which also provides a basis to justify and explain the decision; 2) participatory decision - to take into account the preferences/votes from the stakeholders.001D02B04001D01A08001D02C001D01A14Prise de décision06Decision making06Toma decision06Système aide décision07Decision support system07Sistema ayuda decisíon07Système multiagent08Multiagent system08Sistema multiagente08Intelligence artificielle09Artificial intelligence09Inteligencia artificial09Architecture système10System architecture10Arquitectura sistema10Argumentation11Argumentation11Argumentación11Fonction influence12Influence function12Función influencia12Parc national13National park13Parque nacional13Tourisme14Tourism14Turismo14Gestion entreprise15Firm management15Administración empresa15Stratégie entreprise16Firm strategy16Estrategia empresa16Jeu rôle17Role playing17Juego de funciones17Participation communautaire18Community participation18Participación comunitaria18Négociation19Bargaining19Negociación19Préférence20Preference20Preferencia20Econométrie21Econometrics21Econometría21.INC82Agent logicielCD96Software agentsCD96Agente logicialCD96059OTOOTOPASCAL 11-0097049 INISTDESIGN OF A PARTICIPATORY DECISION MAKING AGENT ARCHITECTURE BASED ON ARGUMENTATION AND INFLUENCE FUNCTION - APPLICATION TO A SERIOUS GAME ABOUT BIODIVERSITY CONSERVATIONSORDONI (Alessandro); BRIOT (Jean-Pierre); ALVAREZ (Isabelle); VASCONCELOS (Eurico); DE AZEVEDO IRVING (Marta); MELO (Gustavo); BARBARESCO (Frédéric)Laboratoire d'Informatique de Paris 6 (LIP6), Université Pierre et Marie Curie - CNRS/Paris/France (1 aut., 2 aut.); Computer Science Department, Pontificia Universidade Católica (PUC-Rio)/Rio de Janeiro, RJ/Brésil (2 aut., 4 aut.); Laboratoire d'Ingénierie pour les Systèmes Complexes (LISC), CEMAGREF/Aubière/France (3 aut.); EICOS Program, Universidade Federal do Rio de Janeiro (UFRJ)/Rio de Janeiro, RJ/Brésil (5 aut., 6 aut.)
Publication en série; Niveau analytique
RAIRO. Recherche opérationnelle; ISSN 0399-0559; Coden RSROD3; France; Da. 2010; Vol. 44; No. 4; Pp. 269-283; Abs. français; Bibl. 13 ref.AnglaisThis paper addresses an ongoing experience in the design of an artificial agent taking decisions and combining them with the decisions taken by human agents. The context is a serious game research project, aimed at computer-based support for participatory management of protected areas (and more specifically national parks) in order to promote biodiversity conservation and social inclusion. Its objective is to help various stakeholders (e.g., environmentalist, tourism operator) to collectively understand conflict dynamics and explore negotiation strategies for the management of parks. In this paper, after introducing the design of our serious game, named SimParc, we will describe the architecture of the decision making agent playing the role of the park manager. In the game, the park manager makes final decisions based on its own analysis and also on the votes of the stakeholders. It includes two modules: 1) individual decision - based on a model of argumentation, which also provides a basis to justify and explain the decision; 2) participatory decision - to take into account the preferences/votes from the stakeholders.001D02B04; 001D01A08; 001D02C; 001D01A14Prise de décision; Système aide décision; Système multiagent; Intelligence artificielle; Architecture système; Argumentation; Fonction influence; Parc national; Tourisme; Gestion entreprise; Stratégie entreprise; Jeu rôle; Participation communautaire; Négociation; Préférence; Econométrie; .; Agent logicielDecision making; Decision support system; Multiagent system; Artificial intelligence; System architecture; Argumentation; Influence function; National park; Tourism; Firm management; Firm strategy; Role playing; Community participation; Bargaining; Preference; Econometrics; Software agentsToma decision; Sistema ayuda decisíon; Sistema multiagente; Inteligencia artificial; Arquitectura sistema; Argumentación; Función influencia; Parque nacional; Turismo; Administración empresa; Estrategia empresa; Juego de funciones; Participación comunitaria; Negociación; Preferencia; Econometría; Agente logicialINIST-9323C.35400019355644001011-0097049 001615 Six-Month Results of the NEVO RES-ELUTION I (NEVO RES-I) Trial: A Randomized, Multicenter Comparison of the NEVO Sirolimus-Eluting Coronary Stent With the TAXUS Liberté Paclitaxel-Eluting Stent in De Novo Native Coronary Artery LesionsJohn A. OrmistonNorth Shore HospitalAucklandNZL1 aut.Alexandre AbizaidInstituto Dante PazzaneseSao PaoloBRA2 aut.John SpertusSt Luke's HospitalKansas City, MoUSA3 aut.Jean FajadetClinique PasteurToulouseFRA4 aut.Laura MauriBrigham and Women's HospitalBoston, MassUSA5 aut.Joachim SchoferHerzkatheterlabor und PraxisklinikHamburgDEU6 aut.Stefan VerheyeMiddelheim HospitalAntwerpBEL7 aut.Joseph DensZiekenhuis Oost-LimburgGenkBEL8 aut.Leif ThuesenSkejby SygehusAarhusDNK9 aut.Christophe DuboisUniversity HospitalLeuvenBEL10 aut.Rainer HoffmannUniversity HospitalAachenDEU11 aut.William WijnsOnze-Lieve-VrouweziekenhuisBEL12 aut.Peter J. FitzgeraldJeffrey J. PopmaNathalie MacoursAna CebrianHans-Peter StollCampbell RogersChristian Spaulding11-00975922010PASCAL 11-0097592 INISTPascal:11-00975920012821941-7640Circ. Cardiovasc. interv.Circulation. Cardiovascular interventionsAngiographyAortocoronaryCarotidCoatingComparative studyComplicationCoronary arteryCoronary heart diseaseDe novoEndoprosthesisHumanInstrumental dilatationMigrationMulticenter studyMyocardial infarctionObstructionPaclitaxelPercutaneous routePolymerPrognosisRelapseRenal arteryRestenosisRevascularizationSirolimusStenosisStentSurvivalThrombosisUltrasoundThromboseCardiopathie coronaireInfarctus du myocardeSténoseEtude multicentriqueEtude comparativeSirolimusStentPaclitaxelDe novoArtère coronaireResténoseComplicationPolymèreEnrobageVoie percutanéeHommeAngiographieRevascularisationUltrasonObstructionDilatation instrumentaleEndoprothèseAortocoronaireArtère rénaleSurviePronosticCarotideMigrationRécidiveAngine poitrine
Background-Drug-eluting stents reduce restenosis and reintervention rates but are complicated by stent thrombosis, which may be related to polymer coating. The NEVO sirolimus-eluting coronary stent (NEVO SES) is designed to improve long-term percutaneous coronary intervention safety by combining sirolimus release from reservoirs with bioabsorbable polymer to reduce spatial and temporal polymer exposure. Methods and Results-NEVO ResElution-I was a prospective randomized study in 394 patients with coronary artery disease comparing the NEVO SES with the TAXUS Liberté paclitaxel-eluting coronary stent (TAXUS Liberté PES) stent. The primary end point was in-stent angiographic late loss at 6 months. Six months after percutaneous coronary intervention (PCI), the primary end point favored NEVO SES (0.13±0.31 mm versus 0.36±0.48 mm, P<0.001 for noninferiority and superiority). The study was not powered for clinical end points and showed no significant difference for NEVO SES versus TAXUS Liberté PES: death: 0.5 versus 1.6%, P=0.36; myocardial infarction: 2.0 versus 2.6%, P=0.75; target lesion revascularization: 1.5 versus 3.2%, P=0.33; major adverse cardiac events: 4.0 versus 7.4%, P=0.19. No stent thrombosis was observed with NEVO SES, whereas 2 cases occurred in TAXUS Liberté PES. Intravascular ultrasound showed lower percent volume obstruction for NEVO SES (5.5±11% versus 11.5±9.7%, P=0.016). Conclusions-This trial proved the superiority of NEVO SES over TAXUS Liberté PES for the primary angiographic end point of in-stent late loss. No stent thrombosis occurred in the NEVO SES group.
1941-7640Circ. Cardiovasc. interv.36Six-Month Results of the NEVO RES-ELUTION I (NEVO RES-I) Trial: A Randomized, Multicenter Comparison of the NEVO Sirolimus-Eluting Coronary Stent With the TAXUS Liberté Paclitaxel-Eluting Stent in De Novo Native Coronary Artery LesionsORMISTON (John A.)ABIZAID (Alexandre)SPERTUS (John)FAJADET (Jean)MAURI (Laura)SCHOFER (Joachim)VERHEYE (Stefan)DENS (Joseph)THUESEN (Leif)DUBOIS (Christophe)HOFFMANN (Rainer)WIJNS (William)FITZGERALD (Peter J.)POPMA (Jeffrey J.)MACOURS (Nathalie)CEBRIAN (Ana)STOLL (Hans-Peter)ROGERS (Campbell)SPAULDING (Christian)North Shore HospitalAucklandNZL1 aut.Instituto Dante PazzaneseSao PaoloBRA2 aut.St Luke's HospitalKansas City, MoUSA3 aut.Clinique PasteurToulouseFRA4 aut.Brigham and Women's HospitalBoston, MassUSA5 aut.Herzkatheterlabor und PraxisklinikHamburgDEU6 aut.Middelheim HospitalAntwerpBEL7 aut.Ziekenhuis Oost-LimburgGenkBEL8 aut.Skejby SygehusAarhusDNK9 aut.University HospitalLeuvenBEL10 aut.University HospitalAachenDEU11 aut.Onze-Lieve-VrouweziekenhuisBEL12 aut.556-5642010ENGINIST280453540001935030600800000© 2011 INIST-CNRS. All rights reserved.29 ref.11-0097592PACirculation. Cardiovascular interventionsUSABackground-Drug-eluting stents reduce restenosis and reintervention rates but are complicated by stent thrombosis, which may be related to polymer coating. The NEVO sirolimus-eluting coronary stent (NEVO SES) is designed to improve long-term percutaneous coronary intervention safety by combining sirolimus release from reservoirs with bioabsorbable polymer to reduce spatial and temporal polymer exposure. Methods and Results-NEVO ResElution-I was a prospective randomized study in 394 patients with coronary artery disease comparing the NEVO SES with the TAXUS Liberté paclitaxel-eluting coronary stent (TAXUS Liberté PES) stent. The primary end point was in-stent angiographic late loss at 6 months. Six months after percutaneous coronary intervention (PCI), the primary end point favored NEVO SES (0.13±0.31 mm versus 0.36±0.48 mm, P<0.001 for noninferiority and superiority). The study was not powered for clinical end points and showed no significant difference for NEVO SES versus TAXUS Liberté PES: death: 0.5 versus 1.6%, P=0.36; myocardial infarction: 2.0 versus 2.6%, P=0.75; target lesion revascularization: 1.5 versus 3.2%, P=0.33; major adverse cardiac events: 4.0 versus 7.4%, P=0.19. No stent thrombosis was observed with NEVO SES, whereas 2 cases occurred in TAXUS Liberté PES. Intravascular ultrasound showed lower percent volume obstruction for NEVO SES (5.5±11% versus 11.5±9.7%, P=0.016). Conclusions-This trial proved the superiority of NEVO SES over TAXUS Liberté PES for the primary angiographic end point of in-stent late loss. No stent thrombosis occurred in the NEVO SES group.002B12B02002B26E002B17CThrombose01Thrombosis01Trombosis01Cardiopathie coronaire02Coronary heart disease02Cardiopatía coronaria02Infarctus du myocardeNM03Myocardial infarctionNM03Infarto miocardioNM03Sténose04Stenosis04Estenosis04Etude multicentrique09Multicenter study09Estudio multicéntrico09Etude comparative10Comparative study10Estudio comparativo10SirolimusNKFR11SirolimusNKFR11SirolimúsNKFR11Stent12Stent12Stent12PaclitaxelNKFR13PaclitaxelNKFR13PaclitaxelNKFR13De novo14De novo14De novo14Artère coronaire15Coronary artery15Arteria coronaria15Resténose16Restenosis16Reestenosis16Complication17Complication17Complicación17Polymère18Polymer18Polímero18Enrobage19Coating19Envoltura19Voie percutanée20Percutaneous route20Vía percutánea20Homme21Human21Hombre21Angiographie22Angiography22Angiografía22Revascularisation23Revascularization23Revascularización23Ultrason24Ultrasound24Ultrasonido24Obstruction25Obstruction25Obstrucción25Dilatation instrumentale26Instrumental dilatation26Dilatación instrumental26Endoprothèse27Endoprosthesis27Endoprotesis27Aortocoronaire28Aortocoronary28Aortocoronaria28Artère rénale29Renal artery29Arteria renal29Survie30Survival30Sobrevivencia30Pronostic31Prognosis31Pronóstico31Carotide32Carotid32Carótida32Migration33Migration33Migración33Récidive34Relapse34Recaida34Angine poitrineINC86Pathologie de l'appareil circulatoire37Cardiovascular disease37Aparato circulatorio patología37Pathologie des vaisseaux sanguins38Vascular disease38Vaso sanguíneo patología38Pathologie du myocarde39Myocardial disease39Miocardio patología39059OTOOTOPASCAL 11-0097592 INISTSix-Month Results of the NEVO RES-ELUTION I (NEVO RES-I) Trial: A Randomized, Multicenter Comparison of the NEVO Sirolimus-Eluting Coronary Stent With the TAXUS Liberté Paclitaxel-Eluting Stent in De Novo Native Coronary Artery LesionsORMISTON (John A.); ABIZAID (Alexandre); SPERTUS (John); FAJADET (Jean); MAURI (Laura); SCHOFER (Joachim); VERHEYE (Stefan); DENS (Joseph); THUESEN (Leif); DUBOIS (Christophe); HOFFMANN (Rainer); WIJNS (William); FITZGERALD (Peter J.); POPMA (Jeffrey J.); MACOURS (Nathalie); CEBRIAN (Ana); STOLL (Hans-Peter); ROGERS (Campbell); SPAULDING (Christian)North Shore Hospital/Auckland/Nouvelle-Zélande (1 aut.); Instituto Dante Pazzanese/Sao Paolo/Brésil (2 aut.); St Luke's Hospital/Kansas City, Mo/Etats-Unis (3 aut.); Clinique Pasteur/Toulouse/France (4 aut.); Brigham and Women's Hospital/Boston, Mass/Etats-Unis (5 aut.); Herzkatheterlabor und Praxisklinik/Hamburg/Allemagne (6 aut.); Middelheim Hospital/Antwerp/Belgique (7 aut.); Ziekenhuis Oost-Limburg/Genk/Belgique (8 aut.); Skejby Sygehus/Aarhus/Danemark (9 aut.); University Hospital/Leuven/Belgique (10 aut.); University Hospital/Aachen/Allemagne (11 aut.); Onze-Lieve-Vrouweziekenhuis/Belgique (12 aut.)
Publication en série; Niveau analytique
Circulation. Cardiovascular interventions; ISSN 1941-7640; Etats-Unis; Da. 2010; Vol. 3; No. 6; Pp. 556-564; Bibl. 29 ref.AnglaisBackground-Drug-eluting stents reduce restenosis and reintervention rates but are complicated by stent thrombosis, which may be related to polymer coating. The NEVO sirolimus-eluting coronary stent (NEVO SES) is designed to improve long-term percutaneous coronary intervention safety by combining sirolimus release from reservoirs with bioabsorbable polymer to reduce spatial and temporal polymer exposure. Methods and Results-NEVO ResElution-I was a prospective randomized study in 394 patients with coronary artery disease comparing the NEVO SES with the TAXUS Liberté paclitaxel-eluting coronary stent (TAXUS Liberté PES) stent. The primary end point was in-stent angiographic late loss at 6 months. Six months after percutaneous coronary intervention (PCI), the primary end point favored NEVO SES (0.13±0.31 mm versus 0.36±0.48 mm, P<0.001 for noninferiority and superiority). The study was not powered for clinical end points and showed no significant difference for NEVO SES versus TAXUS Liberté PES: death: 0.5 versus 1.6%, P=0.36; myocardial infarction: 2.0 versus 2.6%, P=0.75; target lesion revascularization: 1.5 versus 3.2%, P=0.33; major adverse cardiac events: 4.0 versus 7.4%, P=0.19. No stent thrombosis was observed with NEVO SES, whereas 2 cases occurred in TAXUS Liberté PES. Intravascular ultrasound showed lower percent volume obstruction for NEVO SES (5.5±11% versus 11.5±9.7%, P=0.016). Conclusions-This trial proved the superiority of NEVO SES over TAXUS Liberté PES for the primary angiographic end point of in-stent late loss. No stent thrombosis occurred in the NEVO SES group.002B12B02; 002B26E; 002B17CThrombose; Cardiopathie coronaire; Infarctus du myocarde; Sténose; Etude multicentrique; Etude comparative; Sirolimus; Stent; Paclitaxel; De novo; Artère coronaire; Resténose; Complication; Polymère; Enrobage; Voie percutanée; Homme; Angiographie; Revascularisation; Ultrason; Obstruction; Dilatation instrumentale; Endoprothèse; Aortocoronaire; Artère rénale; Survie; Pronostic; Carotide; Migration; Récidive; Angine poitrinePathologie de l'appareil circulatoire; Pathologie des vaisseaux sanguins; Pathologie du myocardeThrombosis; Coronary heart disease; Myocardial infarction; Stenosis; Multicenter study; Comparative study; Sirolimus; Stent; Paclitaxel; De novo; Coronary artery; Restenosis; Complication; Polymer; Coating; Percutaneous route; Human; Angiography; Revascularization; Ultrasound; Obstruction; Instrumental dilatation; Endoprosthesis; Aortocoronary; Renal artery; Survival; Prognosis; Carotid; Migration; RelapseCardiovascular disease; Vascular disease; Myocardial diseaseTrombosis; Cardiopatía coronaria; Infarto miocardio; Estenosis; Estudio multicéntrico; Estudio comparativo; Sirolimús; Stent; Paclitaxel; De novo; Arteria coronaria; Reestenosis; Complicación; Polímero; Envoltura; Vía percutánea; Hombre; Angiografía; Revascularización; Ultrasonido; Obstrucción; Dilatación instrumental; Endoprotesis; Aortocoronaria; Arteria renal; Sobrevivencia; Pronóstico; Carótida; Migración; RecaidaINIST-28045.35400019350306008011-0097592 001616 Safety of Liver Resections in Obese and Overweight PatientsSilvio BalzanFundação Faculdade Federal de Ciências Médicas de Porto Alegre, Universidade de Santa Cruz do SulSanta Cruz do SulBRA1 aut.4 aut.Ganesh NagarajanDepartment of Hepato-Pancreatico-Biliary Surgery and United Federation of Hepato-Gastroenterology and Digestive Surgery, Beaujon Hospital92110 ClichyFRA2 aut.3 aut.5 aut.6 aut.Assistance-Publique Hôpitaux de Paris, University Denis DiderotParisFRA2 aut.3 aut.5 aut.6 aut.7 aut.Olivier FargesDepartment of Hepato-Pancreatico-Biliary Surgery and United Federation of Hepato-Gastroenterology and Digestive Surgery, Beaujon Hospital92110 ClichyFRA2 aut.3 aut.5 aut.6 aut.Assistance-Publique Hôpitaux de Paris, University Denis DiderotParisFRA2 aut.3 aut.5 aut.6 aut.7 aut.Claudio Zettler GalleanoFundação Faculdade Federal de Ciências Médicas de Porto Alegre, Universidade de Santa Cruz do SulSanta Cruz do SulBRA1 aut.4 aut.Safi DokmakDepartment of Hepato-Pancreatico-Biliary Surgery and United Federation of Hepato-Gastroenterology and Digestive Surgery, Beaujon Hospital92110 ClichyFRA2 aut.3 aut.5 aut.6 aut.Assistance-Publique Hôpitaux de Paris, University Denis DiderotParisFRA2 aut.3 aut.5 aut.6 aut.7 aut.Catherine PaugamDepartment of Hepato-Pancreatico-Biliary Surgery and United Federation of Hepato-Gastroenterology and Digestive Surgery, Beaujon Hospital92110 ClichyFRA2 aut.3 aut.5 aut.6 aut.Assistance-Publique Hôpitaux de Paris, University Denis DiderotParisFRA2 aut.3 aut.5 aut.6 aut.7 aut.Jacques BelghitiAssistance-Publique Hôpitaux de Paris, University Denis DiderotParisFRA2 aut.3 aut.5 aut.6 aut.7 aut.11-00991462010PASCAL 11-0099146 INISTPascal:11-00991460012810364-2313World j. surg.World journal of surgeryBody weightHepatectomyHumanMedicineNutritional statusObesityOverweightPatientSafetySurgeryToxicityTreatmentHépatectomieToxicitéSécuritéObésitéSurcharge pondéralePoids corporelHommeMaladeMédecineChirurgieTraitementEtat nutritionnel
Background The new global epidemic, overweight and obesity, has a significant role in the etiology of liver tumors. However, the impact of body weight on the outcome after liver resection is unknown. Methods We carried out a prospective study of 684 patients who underwent liver resections. Patients were stratified according their body mass index (BMI) as follows: normal (<25 kg/m2) (52%), overweight (25-29 kg/m2) (34%), and obese (>30 kg/m2) (14%), and according to the extent of resection, as either minor or major hepatectomy. Preoperative and intraoperative characteristics and outcomes were prospectively studied. The Dindo-Clavien classification of morbidity was used. Results Overall postoperative morbidity and morbidity rates were not influenced by BMI. Pulmonary complications were significantly more frequent in obese patients irrespective of the extent of resection. During major resection obese had longer pedicular clamping and more frequently required blood transfusion. After major resection, major morbidity (Dindo-Clavien grade III or more) was more frequent in obese (57%) and overweight (54%) patients than in patients of normal body weight (35%; P < 0.05), including a higher rate of respiratory complications and ascites and longer intensive care unit (ICU) and hospital stays. Obesity and overweight were independent predictors of major morbidity (OR 2.6, 95% CI 1.2-5.8 and OR 1.9, 95% CI 1.2-3.2, respectively), and obesity was a predictor of the need for blood transfusion (OR 3.3, 95% CI 1.4-7.9) after major resections. Conclusions Obese and overweight patients are at increased risk of potentially life-threatening morbidity after major hepatic resections. Because the risk of mortality is not increased significantly, there is no justification for a compromise in the indication or extent of surgery.
0364-2313WJSUDIWorld j. surg.3412Safety of Liver Resections in Obese and Overweight PatientsBALZAN (Silvio)NAGARAJAN (Ganesh)FARGES (Olivier)ZETTLER GALLEANO (Claudio)DOKMAK (Safi)PAUGAM (Catherine)BELGHITI (Jacques)Department of Hepato-Pancreatico-Biliary Surgery and United Federation of Hepato-Gastroenterology and Digestive Surgery, Beaujon Hospital92110 ClichyFRA2 aut.3 aut.5 aut.6 aut.Assistance-Publique Hôpitaux de Paris, University Denis DiderotParisFRA2 aut.3 aut.5 aut.6 aut.7 aut.Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Universidade de Santa Cruz do SulSanta Cruz do SulBRA1 aut.4 aut.2960-29682010ENGINIST174953540001936150102200000© 2011 INIST-CNRS. All rights reserved.63 ref.11-0099146PAWorld journal of surgeryUSABackground The new global epidemic, overweight and obesity, has a significant role in the etiology of liver tumors. However, the impact of body weight on the outcome after liver resection is unknown. Methods We carried out a prospective study of 684 patients who underwent liver resections. Patients were stratified according their body mass index (BMI) as follows: normal (<25 kg/m2) (52%), overweight (25-29 kg/m2) (34%), and obese (>30 kg/m2) (14%), and according to the extent of resection, as either minor or major hepatectomy. Preoperative and intraoperative characteristics and outcomes were prospectively studied. The Dindo-Clavien classification of morbidity was used. Results Overall postoperative morbidity and morbidity rates were not influenced by BMI. Pulmonary complications were significantly more frequent in obese patients irrespective of the extent of resection. During major resection obese had longer pedicular clamping and more frequently required blood transfusion. After major resection, major morbidity (Dindo-Clavien grade III or more) was more frequent in obese (57%) and overweight (54%) patients than in patients of normal body weight (35%; P < 0.05), including a higher rate of respiratory complications and ascites and longer intensive care unit (ICU) and hospital stays. Obesity and overweight were independent predictors of major morbidity (OR 2.6, 95% CI 1.2-5.8 and OR 1.9, 95% CI 1.2-3.2, respectively), and obesity was a predictor of the need for blood transfusion (OR 3.3, 95% CI 1.4-7.9) after major resections. Conclusions Obese and overweight patients are at increased risk of potentially life-threatening morbidity after major hepatic resections. Because the risk of mortality is not increased significantly, there is no justification for a compromise in the indication or extent of surgery.002B01002B25G03002B22BHépatectomie01Hepatectomy01Hepatectomía01Toxicité02Toxicity02Toxicidad02Sécurité03Safety03Seguridad03Obésité04Obesity04Obesidad04Surcharge pondérale05Overweight05Sobrecarga ponderal05Poids corporel06Body weight06Peso corporal06Homme08Human08Hombre08Malade09Patient09Enfermo09Médecine11Medicine11Medicina11Chirurgie12Surgery12Cirugía12Traitement25Treatment25Tratamiento25Etat nutritionnel26Nutritional status26Estado nutricional26Trouble de la nutrition37Nutrition disorder37Trastorno nutricíon37Biométrie corporelle38Corporal biometry38Biometría corporal38066OTOOTOPASCAL 11-0099146 INISTSafety of Liver Resections in Obese and Overweight PatientsBALZAN (Silvio); NAGARAJAN (Ganesh); FARGES (Olivier); ZETTLER GALLEANO (Claudio); DOKMAK (Safi); PAUGAM (Catherine); BELGHITI (Jacques)Department of Hepato-Pancreatico-Biliary Surgery and United Federation of Hepato-Gastroenterology and Digestive Surgery, Beaujon Hospital/92110 Clichy/France (2 aut., 3 aut., 5 aut., 6 aut.); Assistance-Publique Hôpitaux de Paris, University Denis Diderot/Paris/France (2 aut., 3 aut., 5 aut., 6 aut., 7 aut.); Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Universidade de Santa Cruz do Sul/Santa Cruz do Sul/Brésil (1 aut., 4 aut.)
Publication en série; Niveau analytique
World journal of surgery; ISSN 0364-2313; Coden WJSUDI; Etats-Unis; Da. 2010; Vol. 34; No. 12; Pp. 2960-2968; Bibl. 63 ref.AnglaisBackground The new global epidemic, overweight and obesity, has a significant role in the etiology of liver tumors. However, the impact of body weight on the outcome after liver resection is unknown. Methods We carried out a prospective study of 684 patients who underwent liver resections. Patients were stratified according their body mass index (BMI) as follows: normal (<25 kg/m2) (52%), overweight (25-29 kg/m2) (34%), and obese (>30 kg/m2) (14%), and according to the extent of resection, as either minor or major hepatectomy. Preoperative and intraoperative characteristics and outcomes were prospectively studied. The Dindo-Clavien classification of morbidity was used. Results Overall postoperative morbidity and morbidity rates were not influenced by BMI. Pulmonary complications were significantly more frequent in obese patients irrespective of the extent of resection. During major resection obese had longer pedicular clamping and more frequently required blood transfusion. After major resection, major morbidity (Dindo-Clavien grade III or more) was more frequent in obese (57%) and overweight (54%) patients than in patients of normal body weight (35%; P < 0.05), including a higher rate of respiratory complications and ascites and longer intensive care unit (ICU) and hospital stays. Obesity and overweight were independent predictors of major morbidity (OR 2.6, 95% CI 1.2-5.8 and OR 1.9, 95% CI 1.2-3.2, respectively), and obesity was a predictor of the need for blood transfusion (OR 3.3, 95% CI 1.4-7.9) after major resections. Conclusions Obese and overweight patients are at increased risk of potentially life-threatening morbidity after major hepatic resections. Because the risk of mortality is not increased significantly, there is no justification for a compromise in the indication or extent of surgery.002B01; 002B25G03; 002B22BHépatectomie; Toxicité; Sécurité; Obésité; Surcharge pondérale; Poids corporel; Homme; Malade; Médecine; Chirurgie; Traitement; Etat nutritionnelTrouble de la nutrition; Biométrie corporelleHepatectomy; Toxicity; Safety; Obesity; Overweight; Body weight; Human; Patient; Medicine; Surgery; Treatment; Nutritional statusNutrition disorder; Corporal biometryHepatectomía; Toxicidad; Seguridad; Obesidad; Sobrecarga ponderal; Peso corporal; Hombre; Enfermo; Medicina; Cirugía; Tratamiento; Estado nutricionalINIST-17495.35400019361501022011-0099146 001617 The modulational instability in deep water under the action of wind and dissipationC. KharifInstitut de Recherche sur les Phénomènes Hors Équilibre, 49, rue F. Joliot-Curie, BP 14613384 MarseilleFRA1 aut.4 aut.R. A. KraenkelInstitute de Fisica Teorica, UNESP, R. Pamplona 14501405-900 São PauloBRA2 aut.M. A. MannaLaboratoire de Physique Théorique et Astroparticules, CNRS-UMR 5207, Université Montpellier II, Place Eugène Bataillon34095 MontpellierFRA3 aut.R. ThomasInstitut de Recherche sur les Phénomènes Hors Équilibre, 49, rue F. Joliot-Curie, BP 14613384 MarseilleFRA1 aut.4 aut.11-00999382010PASCAL 11-0099938 INISTPascal:11-00999380012800022-1120J. Fluid Mech.Journal of Fluid MechanicsDeep waterModelingModulational instabilitySurface gravity waveWave trainWind waveocean-atmosphere interactionInteraction atmosphère océanOnde surface gravitéModélisationEau profondeVague ventInstabilité modulationTrain onde
The modulational instability of gravity wave trains on the surface of water acted upon by wind and under influence of viscosity is considered. The wind regime is that of validity of Miles' theory and the viscosity is small. By using a perturbed nonlinear Schrödinger equation describing the evolution of a narrow-banded wavepacket under the action of wind and dissipation, the modulational instability of the wave group is shown to depend on both the frequency (or wavenumber) of the carrier wave and the strength of the friction velocity (or the wind speed). For fixed values of the water-surface roughness, the marginal curves separating stable states from unstable states are given. It is found in the low-frequency regime that stronger wind velocities are needed to sustain the modulational instability than for high-frequency water waves. In other words, the critical frequency decreases as the carrier wave age increases. Furthermore, it is shown for a given carrier frequency that a larger friction velocity is needed to sustain modulational instability when the roughness length is increased.
0022-1120JFLSA7J. Fluid Mech.664The modulational instability in deep water under the action of wind and dissipationKHARIF (C.)KRAENKEL (R. A.)MANNA (M. A.)THOMAS (R.)Institut de Recherche sur les Phénomènes Hors Équilibre, 49, rue F. Joliot-Curie, BP 14613384 MarseilleFRA1 aut.4 aut.Institute de Fisica Teorica, UNESP, R. Pamplona 14501405-900 São PauloBRA2 aut.Laboratoire de Physique Théorique et Astroparticules, CNRS-UMR 5207, Université Montpellier II, Place Eugène Bataillon34095 MontpellierFRA3 aut.138-1492010ENGINIST51803540001949899800700000© 2011 INIST-CNRS. All rights reserved.1/2 p.11-0099938PAJournal of Fluid MechanicsGBRThe modulational instability of gravity wave trains on the surface of water acted upon by wind and under influence of viscosity is considered. The wind regime is that of validity of Miles' theory and the viscosity is small. By using a perturbed nonlinear Schrödinger equation describing the evolution of a narrow-banded wavepacket under the action of wind and dissipation, the modulational instability of the wave group is shown to depend on both the frequency (or wavenumber) of the carrier wave and the strength of the friction velocity (or the wind speed). For fixed values of the water-surface roughness, the marginal curves separating stable states from unstable states are given. It is found in the low-frequency regime that stronger wind velocities are needed to sustain the modulational instability than for high-frequency water waves. In other words, the critical frequency decreases as the carrier wave age increases. Furthermore, it is shown for a given carrier frequency that a larger friction velocity is needed to sustain modulational instability when the roughness length is increased.001E02B04Interaction atmosphère océan08ocean-atmosphere interaction08Onde surface gravité09Surface gravity wave09Onda superficie gravedad09Modélisation15Modeling15Modelización15Eau profonde29Deep water29Agua profunda29Vague vent30Wind wave30Ola viento30Instabilité modulation31Modulational instability31Inestabilidad modulación31Train onde32Wave train32Tren ondas32066PASCAL 11-0099938 INISTThe modulational instability in deep water under the action of wind and dissipationKHARIF (C.); KRAENKEL (R. A.); MANNA (M. A.); THOMAS (R.)Institut de Recherche sur les Phénomènes Hors Équilibre, 49, rue F. Joliot-Curie, BP 146/13384 Marseille/France (1 aut., 4 aut.); Institute de Fisica Teorica, UNESP, R. Pamplona 145/01405-900 São Paulo/Brésil (2 aut.); Laboratoire de Physique Théorique et Astroparticules, CNRS-UMR 5207, Université Montpellier II, Place Eugène Bataillon/34095 Montpellier/France (3 aut.)
Publication en série; Niveau analytique
Journal of Fluid Mechanics; ISSN 0022-1120; Coden JFLSA7; Royaume-Uni; Da. 2010; Vol. 664; Pp. 138-149; Bibl. 1/2 p.AnglaisThe modulational instability of gravity wave trains on the surface of water acted upon by wind and under influence of viscosity is considered. The wind regime is that of validity of Miles' theory and the viscosity is small. By using a perturbed nonlinear Schrödinger equation describing the evolution of a narrow-banded wavepacket under the action of wind and dissipation, the modulational instability of the wave group is shown to depend on both the frequency (or wavenumber) of the carrier wave and the strength of the friction velocity (or the wind speed). For fixed values of the water-surface roughness, the marginal curves separating stable states from unstable states are given. It is found in the low-frequency regime that stronger wind velocities are needed to sustain the modulational instability than for high-frequency water waves. In other words, the critical frequency decreases as the carrier wave age increases. Furthermore, it is shown for a given carrier frequency that a larger friction velocity is needed to sustain modulational instability when the roughness length is increased.001E02B04Interaction atmosphère océan; Onde surface gravité; Modélisation; Eau profonde; Vague vent; Instabilité modulation; Train ondeocean-atmosphere interaction; Surface gravity wave; Modeling; Deep water; Wind wave; Modulational instability; Wave trainOnda superficie gravedad; Modelización; Agua profunda; Ola viento; Inestabilidad modulación; Tren ondasINIST-5180.35400019498998007011-0099938 001618 The effect of n-, s- and t-butanol on the micellization and gelation of Pluronic P123 in aqueous solutionN Gila M. P. S. RicardoDepartment of Organic and Inorganic Chemistry, Federal University of CearáCX 12200 FortalezaBRA1 aut.2 aut.3 aut.Nadja M. P. S. RicardoDepartment of Organic and Inorganic Chemistry, Federal University of CearáCX 12200 FortalezaBRA1 aut.2 aut.3 aut.Flavia De M. L. L. CostaDepartment of Organic and Inorganic Chemistry, Federal University of CearáCX 12200 FortalezaBRA1 aut.2 aut.3 aut.Chiraphon ChaibunditDepartment of Materials Science and Technology, Faculty of Science, Prince of Songkla UniversityHat Yai, Songkhla 90112THA4 aut.Giuseppe PortaleESRF, 6 Rue Jules Horowitz, BP 22038043 GrenobleFRA5 aut.Daniel Hermida-MerinoDepartment of Chemistry, University of ReadingReading RG6 6ADGBR6 aut.7 aut.8 aut.Stefano BurattiniDepartment of Chemistry, University of ReadingReading RG6 6ADGBR6 aut.7 aut.8 aut.Ian W. HamleyDepartment of Chemistry, University of ReadingReading RG6 6ADGBR6 aut.7 aut.8 aut.Christopher A. MurynSchool of Chemistry, University of ManchesterManchester M13 9PLGBR9 aut.10 aut.11 aut.S. Keith NixonSchool of Chemistry, University of ManchesterManchester M13 9PLGBR9 aut.10 aut.11 aut.Stephen G. YeatesSchool of Chemistry, University of ManchesterManchester M13 9PLGBR9 aut.10 aut.11 aut.11-00999492011PASCAL 11-0099949 INISTPascal:11-00999490012790021-9797J. colloid interface sci.Journal of colloid and interface scienceAqueous solutionButanolConcentrated solutionCopolymerCritical temperatureDilute solutionDynamicsElastic modulusGelationHeatingLight scatteringMesoporosityMicelleMicellizationMobilityPoloxamerPorous materialSmall angle X ray scatteringStructureSynthesisTemplateWaterButanolMicellisationGélificationPoloxamèreSolution aqueuseEauMicelleStructureSolution diluéeCopolymèreSolution concentréeSynthèseMésoporositéMatériau poreuxDynamiqueDiffusion lumièreMobilitéDiffusion RX centraleChauffageTempérature critiqueModule élasticitéAgent structurant
In dilute aqueous solution unimers of copolymer P123 (E21P67E21) associate to form micelles, and in more concentrated solution micelles pack to form high-modulus gels. We are interested in the use of the system as a templating agent in the synthesis of mesoporous materials, and the possibility of determining gel structure, hence mesoporosity, by use of n-, s- or t-butanol. Dynamic light scattering from clear dilute solutions has been used to confirm micellization, visual observation of mobility (tube inversion) to detect gel formation in concentrated solutions, oscillatory rheometry to confirm gel formation and provide values of elastic moduli over a wide temperature range, and small-angle X-ray scattering to determine gel structure. As expected, clear cubic gels (fcc) formed at moderate concentrations and temperatures, e.g. 30 wt.% P123, 20 °C, and clear hexagonal gels at higher concentrations and temperatures. The transition on heating from cubic to hexagonal gel involved an intermediate turbid phase in which cubic and hex structures coexisted. Considering cubic gels of 35 wt.% P123 in 5 wt.% butanol/water, those in n-butanol/water had the lowest critical temperatures for gel formation and the highest maximum values for the dynamic elastic modulus (G') of the gels, a result consistent with n-butanol/water being the poorest solvent for P123.
0021-9797JCISA5J. colloid interface sci.3532The effect of n-, s- and t-butanol on the micellization and gelation of Pluronic P123 in aqueous solutionRICARDO (Nágila M. P. S.)RICARDO (Nadja M. P. S.)COSTA (Flavia De M. L. L.)CHAIBUNDIT (Chiraphon)PORTALE (Giuseppe)HERMIDA-MERINO (Daniel)BURATTINI (Stefano)HAMLEY (Ian W.)MURYN (Christopher A.)NIXON (S. Keith)YEATES (Stephen G.)Department of Organic and Inorganic Chemistry, Federal University of CearáCX 12200 FortalezaBRA1 aut.2 aut.3 aut.Department of Materials Science and Technology, Faculty of Science, Prince of Songkla UniversityHat Yai, Songkhla 90112THA4 aut.ESRF, 6 Rue Jules Horowitz, BP 22038043 GrenobleFRA5 aut.Department of Chemistry, University of ReadingReading RG6 6ADGBR6 aut.7 aut.8 aut.School of Chemistry, University of ManchesterManchester M13 9PLGBR9 aut.10 aut.11 aut.482-4892011ENGINIST41243540001935797001800000© 2011 INIST-CNRS. All rights reserved.19 ref.11-0099949PAJournal of colloid and interface scienceNLDIn dilute aqueous solution unimers of copolymer P123 (E21P67E21) associate to form micelles, and in more concentrated solution micelles pack to form high-modulus gels. We are interested in the use of the system as a templating agent in the synthesis of mesoporous materials, and the possibility of determining gel structure, hence mesoporosity, by use of n-, s- or t-butanol. Dynamic light scattering from clear dilute solutions has been used to confirm micellization, visual observation of mobility (tube inversion) to detect gel formation in concentrated solutions, oscillatory rheometry to confirm gel formation and provide values of elastic moduli over a wide temperature range, and small-angle X-ray scattering to determine gel structure. As expected, clear cubic gels (fcc) formed at moderate concentrations and temperatures, e.g. 30 wt.% P123, 20 °C, and clear hexagonal gels at higher concentrations and temperatures. The transition on heating from cubic to hexagonal gel involved an intermediate turbid phase in which cubic and hex structures coexisted. Considering cubic gels of 35 wt.% P123 in 5 wt.% butanol/water, those in n-butanol/water had the lowest critical temperatures for gel formation and the highest maximum values for the dynamic elastic modulus (G') of the gels, a result consistent with n-butanol/water being the poorest solvent for P123.001C01J03001C01J08ButanolNKFX01ButanolNKFX01ButanolNKFX01Micellisation02Micellization02Micelización02Gélification03Gelation03Gelificación03PoloxamèreNKFR04PoloxamerNKFR04PoloxámeroNKFR04Solution aqueuse05Aqueous solution05Solución acuosa05Eau06Water06Agua06Micelle07Micelle07Micela07Structure08Structure08Estructura08Solution diluée11Dilute solution11Solución diluida11CopolymèreNK12CopolymerNK12CopolímeroNK12Solution concentrée13Concentrated solution13Solución concentrada13Synthèse14Synthesis14Síntesis14Mésoporosité15Mesoporosity15Mesoporosidad15Matériau poreux16Porous material16Material poroso16Dynamique17Dynamics17Dinámica17Diffusion lumière18Light scattering18Difusión luz18Mobilité19Mobility19Movilidad19Diffusion RX centrale20Small angle X ray scattering20Difusión rayo X central20Chauffage21Heating21Calefacción21Température critique22Critical temperature22Temperatura crítica22Module élasticité23Elastic modulus23Módulo elasticidad23Agent structurantCD96TemplateCD96Alcanol09Alkanol09Alcanol09Alcool10Alcohol10Alcohol10Propriété critique24Critical property24Propiedad crítica24066OTOOTOPASCAL 11-0099949 INISTThe effect of n-, s- and t-butanol on the micellization and gelation of Pluronic P123 in aqueous solutionRICARDO (Nágila M. P. S.); RICARDO (Nadja M. P. S.); COSTA (Flavia De M. L. L.); CHAIBUNDIT (Chiraphon); PORTALE (Giuseppe); HERMIDA-MERINO (Daniel); BURATTINI (Stefano); HAMLEY (Ian W.); MURYN (Christopher A.); NIXON (S. Keith); YEATES (Stephen G.)Department of Organic and Inorganic Chemistry, Federal University of Ceará/CX 12200 Fortaleza/Brésil (1 aut., 2 aut., 3 aut.); Department of Materials Science and Technology, Faculty of Science, Prince of Songkla University/Hat Yai, Songkhla 90112/Thaïlande (4 aut.); ESRF, 6 Rue Jules Horowitz, BP 220/38043 Grenoble/France (5 aut.); Department of Chemistry, University of Reading/Reading RG6 6AD/Royaume-Uni (6 aut., 7 aut., 8 aut.); School of Chemistry, University of Manchester/Manchester M13 9PL/Royaume-Uni (9 aut., 10 aut., 11 aut.)
Publication en série; Niveau analytique
Journal of colloid and interface science; ISSN 0021-9797; Coden JCISA5; Pays-Bas; Da. 2011; Vol. 353; No. 2; Pp. 482-489; Bibl. 19 ref.AnglaisIn dilute aqueous solution unimers of copolymer P123 (E21P67E21) associate to form micelles, and in more concentrated solution micelles pack to form high-modulus gels. We are interested in the use of the system as a templating agent in the synthesis of mesoporous materials, and the possibility of determining gel structure, hence mesoporosity, by use of n-, s- or t-butanol. Dynamic light scattering from clear dilute solutions has been used to confirm micellization, visual observation of mobility (tube inversion) to detect gel formation in concentrated solutions, oscillatory rheometry to confirm gel formation and provide values of elastic moduli over a wide temperature range, and small-angle X-ray scattering to determine gel structure. As expected, clear cubic gels (fcc) formed at moderate concentrations and temperatures, e.g. 30 wt.% P123, 20 °C, and clear hexagonal gels at higher concentrations and temperatures. The transition on heating from cubic to hexagonal gel involved an intermediate turbid phase in which cubic and hex structures coexisted. Considering cubic gels of 35 wt.% P123 in 5 wt.% butanol/water, those in n-butanol/water had the lowest critical temperatures for gel formation and the highest maximum values for the dynamic elastic modulus (G') of the gels, a result consistent with n-butanol/water being the poorest solvent for P123.001C01J03; 001C01J08Butanol; Micellisation; Gélification; Poloxamère; Solution aqueuse; Eau; Micelle; Structure; Solution diluée; Copolymère; Solution concentrée; Synthèse; Mésoporosité; Matériau poreux; Dynamique; Diffusion lumière; Mobilité; Diffusion RX centrale; Chauffage; Température critique; Module élasticité; Agent structurantAlcanol; Alcool; Propriété critiqueButanol; Micellization; Gelation; Poloxamer; Aqueous solution; Water; Micelle; Structure; Dilute solution; Copolymer; Concentrated solution; Synthesis; Mesoporosity; Porous material; Dynamics; Light scattering; Mobility; Small angle X ray scattering; Heating; Critical temperature; Elastic modulus; TemplateAlkanol; Alcohol; Critical propertyButanol; Micelización; Gelificación; Poloxámero; Solución acuosa; Agua; Micela; Estructura; Solución diluida; Copolímero; Solución concentrada; Síntesis; Mesoporosidad; Material poroso; Dinámica; Difusión luz; Movilidad; Difusión rayo X central; Calefacción; Temperatura crítica; Módulo elasticidadINIST-4124.35400019357970018011-0099949 001619 Triplicity and physical characteristics of Asteroid (216) KleopatraP. DescampsInstitut de Méconique Céleste et de Calcul des Éphémérides, Observatoire de Paris, UMR8028 CNRS, 77 av. Denfert-Rochereau75014 ParisFRA1 aut.2 aut.3 aut.10 aut.16 aut.F. MarchisInstitut de Méconique Céleste et de Calcul des Éphémérides, Observatoire de Paris, UMR8028 CNRS, 77 av. Denfert-Rochereau75014 ParisFRA1 aut.2 aut.3 aut.10 aut.16 aut.University of California at Berkeley, Department of Astronomy, 601 Campbell HallBerkeley, CA 94720USA2 aut.5 aut.6 aut.7 aut.SETI Institute, Carl Sagan Center, 515 N. Whisman RoadMountain View, CA 94043USA2 aut.19 aut.J. BerthierInstitut de Méconique Céleste et de Calcul des Éphémérides, Observatoire de Paris, UMR8028 CNRS, 77 av. Denfert-Rochereau75014 ParisFRA1 aut.2 aut.3 aut.10 aut.16 aut.J. P. EmeryUniversity of Tennessee at Knoxville, 306 EPS Building, 1412 Circle DriveKnoxville, TN 37996USA4 aut.8 aut.G. DucheneUniversity of California at Berkeley, Department of Astronomy, 601 Campbell HallBerkeley, CA 94720USA2 aut.5 aut.6 aut.7 aut.Université Joseph Fourier, Grenoble 1/CNRS, Laboratoire d'Astrophysique de Grenoble (LAOG), UMR5571, BP 5338041 GrenobleFRA5 aut.I. De PaterUniversity of California at Berkeley, Department of Astronomy, 601 Campbell HallBerkeley, CA 94720USA2 aut.5 aut.6 aut.7 aut.M. H. WongUniversity of California at Berkeley, Department of Astronomy, 601 Campbell HallBerkeley, CA 94720USA2 aut.5 aut.6 aut.7 aut.L. LimUniversity of Tennessee at Knoxville, 306 EPS Building, 1412 Circle DriveKnoxville, TN 37996USA4 aut.8 aut.H. B. HammelSpace Science InstituteBoulder, CO 80303USA9 aut.F. VachierInstitut de Méconique Céleste et de Calcul des Éphémérides, Observatoire de Paris, UMR8028 CNRS, 77 av. Denfert-Rochereau75014 ParisFRA1 aut.2 aut.3 aut.10 aut.16 aut.P. WigginsWiggins Observatory, 472 Country ClubTooele, UT 84074_9665USA11 aut.J.-P. Teng-Chuen-YuMakes Observatory, 18, rue G. Bizet, Les Makes97421 La RivièreFRA12 aut.13 aut.A. PeyrotMakes Observatory, 18, rue G. Bizet, Les Makes97421 La RivièreFRA12 aut.13 aut.J. PollockAppalachian State University, Department of Physics and Astronomy, 231 CAP BuildingBoone, NC 28608USA14 aut.M. AssafinObservatório do Valongo/UFRJ - Universidade Federal do Rio de Janeiro, Rua Ladeira Pedro Antonio, 43CEP 20080-090 Rio de JaneiroBRA15 aut.17 aut.18 aut.R. Vieira-MartinsInstitut de Méconique Céleste et de Calcul des Éphémérides, Observatoire de Paris, UMR8028 CNRS, 77 av. Denfert-Rochereau75014 ParisFRA1 aut.2 aut.3 aut.10 aut.16 aut.Observatório Nacional/MCT, R. Gal. José Cristino 77CEP20921-400 RJBRA16 aut.17 aut.18 aut.J. I. B. CamargoObservatório do Valongo/UFRJ - Universidade Federal do Rio de Janeiro, Rua Ladeira Pedro Antonio, 43CEP 20080-090 Rio de JaneiroBRA15 aut.17 aut.18 aut.Observatório Nacional/MCT, R. Gal. José Cristino 77CEP20921-400 RJBRA16 aut.17 aut.18 aut.F. Braga-RibasObservatório do Valongo/UFRJ - Universidade Federal do Rio de Janeiro, Rua Ladeira Pedro Antonio, 43CEP 20080-090 Rio de JaneiroBRA15 aut.17 aut.18 aut.Observatório Nacional/MCT, R. Gal. José Cristino 77CEP20921-400 RJBRA16 aut.17 aut.18 aut.B. MacomberSETI Institute, Carl Sagan Center, 515 N. Whisman RoadMountain View, CA 94043USA2 aut.19 aut.11-01026312011PASCAL 11-0102631 INISTPascal:11-01026310012780019-1035Icarus : (N.Y. N.Y. 1962)Icarus : (New York, N.Y. 1962)Adaptive opticsAngular momentumAsteroidsBulk densityOccultationsOrbit determinationOrbitsPhotometryRadar observationSolar systemSpectroscopical observationAstéroïdeOptique adaptativeObservation spectroscopiqueOccultationObservation radarOrbiteDensité volumiqueMoment cinétiquePhotométrieDétermination orbiteSystème solaire
To take full advantage of the September 2008 opposition passage of the M-type Asteroid (216) Kleopatra, we have used near-infrared adaptive optics (AO) imaging with the W.M. Keck II telescope to capture unprecedented high resolution images of this unusual asteroid. Our AO observations with the W.M. Keck II telescope, combined with Spitzer/IRS spectroscopic observations and past stellar occultations, confirm the value of its IRAS radiometric radius of 67.5 km as well as its dog-bone shape suggested by earlier radar observations. Our Keck AO observations revealed the presence of two small satellites in orbit about Kleopatra (see Marchis, F. et al. [2008a]. (3749) Balam. In: Green, D.W.E. (Ed.), IAU Circ. 8928; Marchis, F., Descamps, P., Berthier, J., Emery, J.P. [2008b]. S/2008 ((216)) 1 and S/2008 ((216)) 2. In: Green, D.W.E. (Ed.), IAU Circ. 8980). Accurate measurements of the satellite orbits over a full month enabled us to determine the total mass of the system to be 4.64±0.02 x 1018 kg. This translates into a bulk density of 3.6 ± 0.4 g/cm3, which implies a macroscopic porosity for Kleopatra of ∼30-50%, typical of a rubble-pile asteroid. From these physical characteristics we measured its specific angular momentum, very close to that of a spinning equilibrium dumbbell.
0019-1035ICRSA5Icarus : (N.Y. N.Y. 1962)2112Triplicity and physical characteristics of Asteroid (216) KleopatraDESCAMPS (P.)MARCHIS (F.)BERTHIER (J.)EMERY (J. P.)DUCHENE (G.)DE PATER (I.)WONG (M. H.)LIM (L.)HAMMEL (H. B.)VACHIER (F.)WIGGINS (P.)TENG-CHUEN-YU (J.-P.)PEYROT (A.)POLLOCK (J.)ASSAFIN (M.)VIEIRA-MARTINS (R.)CAMARGO (J. I. B.)BRAGA-RIBAS (F.)MACOMBER (B.)Institut de Méconique Céleste et de Calcul des Éphémérides, Observatoire de Paris, UMR8028 CNRS, 77 av. Denfert-Rochereau75014 ParisFRA1 aut.2 aut.3 aut.10 aut.16 aut.University of California at Berkeley, Department of Astronomy, 601 Campbell HallBerkeley, CA 94720USA2 aut.5 aut.6 aut.7 aut.University of Tennessee at Knoxville, 306 EPS Building, 1412 Circle DriveKnoxville, TN 37996USA4 aut.8 aut.Université Joseph Fourier, Grenoble 1/CNRS, Laboratoire d'Astrophysique de Grenoble (LAOG), UMR5571, BP 5338041 GrenobleFRA5 aut.Space Science InstituteBoulder, CO 80303USA9 aut.Wiggins Observatory, 472 Country ClubTooele, UT 84074_9665USA11 aut.Makes Observatory, 18, rue G. Bizet, Les Makes97421 La RivièreFRA12 aut.13 aut.Appalachian State University, Department of Physics and Astronomy, 231 CAP BuildingBoone, NC 28608USA14 aut.Observatório do Valongo/UFRJ - Universidade Federal do Rio de Janeiro, Rua Ladeira Pedro Antonio, 43CEP 20080-090 Rio de JaneiroBRA15 aut.17 aut.18 aut.Observatório Nacional/MCT, R. Gal. José Cristino 77CEP20921-400 RJBRA16 aut.17 aut.18 aut.SETI Institute, Carl Sagan Center, 515 N. Whisman RoadMountain View, CA 94043USA2 aut.19 aut.1022-10332011ENGINIST101963540001919302900800000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0102631PAIcarus : (New York, N.Y. 1962)NLDTo take full advantage of the September 2008 opposition passage of the M-type Asteroid (216) Kleopatra, we have used near-infrared adaptive optics (AO) imaging with the W.M. Keck II telescope to capture unprecedented high resolution images of this unusual asteroid. Our AO observations with the W.M. Keck II telescope, combined with Spitzer/IRS spectroscopic observations and past stellar occultations, confirm the value of its IRAS radiometric radius of 67.5 km as well as its dog-bone shape suggested by earlier radar observations. Our Keck AO observations revealed the presence of two small satellites in orbit about Kleopatra (see Marchis, F. et al. [2008a]. (3749) Balam. In: Green, D.W.E. (Ed.), IAU Circ. 8928; Marchis, F., Descamps, P., Berthier, J., Emery, J.P. [2008b]. S/2008 ((216)) 1 and S/2008 ((216)) 2. In: Green, D.W.E. (Ed.), IAU Circ. 8980). Accurate measurements of the satellite orbits over a full month enabled us to determine the total mass of the system to be 4.64±0.02 x 1018 kg. This translates into a bulk density of 3.6 ± 0.4 g/cm3, which implies a macroscopic porosity for Kleopatra of ∼30-50%, typical of a rubble-pile asteroid. From these physical characteristics we measured its specific angular momentum, very close to that of a spinning equilibrium dumbbell.001E03BAstéroïde26Asteroids26Optique adaptative27Adaptive optics27Observation spectroscopique28Spectroscopical observation28Observación espectroscópica28Occultation29Occultations29Observation radar30Radar observation30Observación radar30Orbite31Orbits31Densité volumique32Bulk density32Moment cinétique33Angular momentum33Photométrie34Photometry34Détermination orbite35Orbit determination35Système solaire36Solar system36066OTOOTOPASCAL 11-0102631 INISTTriplicity and physical characteristics of Asteroid (216) KleopatraDESCAMPS (P.); MARCHIS (F.); BERTHIER (J.); EMERY (J. P.); DUCHENE (G.); DE PATER (I.); WONG (M. H.); LIM (L.); HAMMEL (H. B.); VACHIER (F.); WIGGINS (P.); TENG-CHUEN-YU (J.-P.); PEYROT (A.); POLLOCK (J.); ASSAFIN (M.); VIEIRA-MARTINS (R.); CAMARGO (J. I. B.); BRAGA-RIBAS (F.); MACOMBER (B.)Institut de Méconique Céleste et de Calcul des Éphémérides, Observatoire de Paris, UMR8028 CNRS, 77 av. Denfert-Rochereau/75014 Paris/France (1 aut., 2 aut., 3 aut., 10 aut., 16 aut.); University of California at Berkeley, Department of Astronomy, 601 Campbell Hall/Berkeley, CA 94720/Etats-Unis (2 aut., 5 aut., 6 aut., 7 aut.); University of Tennessee at Knoxville, 306 EPS Building, 1412 Circle Drive/Knoxville, TN 37996/Etats-Unis (4 aut., 8 aut.); Université Joseph Fourier, Grenoble 1/CNRS, Laboratoire d'Astrophysique de Grenoble (LAOG), UMR5571, BP 53/38041 Grenoble/France (5 aut.); Space Science Institute/Boulder, CO 80303/Etats-Unis (9 aut.); Wiggins Observatory, 472 Country Club/Tooele, UT 84074_9665/Etats-Unis (11 aut.); Makes Observatory, 18, rue G. Bizet, Les Makes/97421 La Rivière/France (12 aut., 13 aut.); Appalachian State University, Department of Physics and Astronomy, 231 CAP Building/Boone, NC 28608/Etats-Unis (14 aut.); Observatório do Valongo/UFRJ - Universidade Federal do Rio de Janeiro, Rua Ladeira Pedro Antonio, 43/CEP 20080-090 Rio de Janeiro/Brésil (15 aut., 17 aut., 18 aut.); Observatório Nacional/MCT, R. Gal. José Cristino 77/CEP20921-400 RJ/Brésil (16 aut., 17 aut., 18 aut.); SETI Institute, Carl Sagan Center, 515 N. Whisman Road/Mountain View, CA 94043/Etats-Unis (2 aut., 19 aut.)
Publication en série; Niveau analytique
Icarus : (New York, N.Y. 1962); ISSN 0019-1035; Coden ICRSA5; Pays-Bas; Da. 2011; Vol. 211; No. 2; Pp. 1022-1033; Bibl. 3/4 p.AnglaisTo take full advantage of the September 2008 opposition passage of the M-type Asteroid (216) Kleopatra, we have used near-infrared adaptive optics (AO) imaging with the W.M. Keck II telescope to capture unprecedented high resolution images of this unusual asteroid. Our AO observations with the W.M. Keck II telescope, combined with Spitzer/IRS spectroscopic observations and past stellar occultations, confirm the value of its IRAS radiometric radius of 67.5 km as well as its dog-bone shape suggested by earlier radar observations. Our Keck AO observations revealed the presence of two small satellites in orbit about Kleopatra (see Marchis, F. et al. [2008a]. (3749) Balam. In: Green, D.W.E. (Ed.), IAU Circ. 8928; Marchis, F., Descamps, P., Berthier, J., Emery, J.P. [2008b]. S/2008 ((216)) 1 and S/2008 ((216)) 2. In: Green, D.W.E. (Ed.), IAU Circ. 8980). Accurate measurements of the satellite orbits over a full month enabled us to determine the total mass of the system to be 4.64±0.02 x 1018 kg. This translates into a bulk density of 3.6 ± 0.4 g/cm3, which implies a macroscopic porosity for Kleopatra of ∼30-50%, typical of a rubble-pile asteroid. From these physical characteristics we measured its specific angular momentum, very close to that of a spinning equilibrium dumbbell.001E03BAstéroïde; Optique adaptative; Observation spectroscopique; Occultation; Observation radar; Orbite; Densité volumique; Moment cinétique; Photométrie; Détermination orbite; Système solaireAsteroids; Adaptive optics; Spectroscopical observation; Occultations; Radar observation; Orbits; Bulk density; Angular momentum; Photometry; Orbit determination; Solar systemObservación espectroscópica; Observación radarINIST-10196.35400019193029008011-0102631 001620 Mutation in IFT80 in a fetus with the phenotype of Verma-Naumoff provides molecular evidence for Jeune-Verma-Naumoff dysplasia spectrumDenise P. CavalcantiPerinatal Genetic Program, Department of Medical Genetic, FCM, UNICAMPCampinas, São PauloBRA1 aut.Department of Genetics, INSERM U 781, Université Paris Descartes, AP-HP, Hôpital Necker Enfants MaladesParisFRA1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.11 aut.12 aut.13 aut.Celine HuberDepartment of Genetics, INSERM U 781, Université Paris Descartes, AP-HP, Hôpital Necker Enfants MaladesParisFRA1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.11 aut.12 aut.13 aut.Kim-Hanh Le Quan SangDepartment of Genetics, INSERM U 781, Université Paris Descartes, AP-HP, Hôpital Necker Enfants MaladesParisFRA1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.11 aut.12 aut.13 aut.Geneviève BaujatDepartment of Genetics, INSERM U 781, Université Paris Descartes, AP-HP, Hôpital Necker Enfants MaladesParisFRA1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.11 aut.12 aut.13 aut.Felicity CollinsWestern Sydney Genetics Program, Department of Clinical Genetics, Children's Hospital at WestmeadSydneyAUS5 aut.Anne-Lise DelezoideService de Biologie de Développement, Université Paris Diderot, Hôpital Robert DebréParisFRA6 aut.Nathalie DagoneauDepartment of Genetics, INSERM U 781, Université Paris Descartes, AP-HP, Hôpital Necker Enfants MaladesParisFRA1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.11 aut.12 aut.13 aut.Martine Le MerrerDepartment of Genetics, INSERM U 781, Université Paris Descartes, AP-HP, Hôpital Necker Enfants MaladesParisFRA1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.11 aut.12 aut.13 aut.Jelena MartinovicUnit of Fetal Pathology, Department of Histo-Embryology and Cytogenetics, Hôpital Necker-Enfants MaladesParisFRA9 aut.Marcos Fernando S. MelloDepartment of Pathology, FCM, UNICAMPCampinas, São PauloBRA10 aut.Michel VekemansDepartment of Genetics, INSERM U 781, Université Paris Descartes, AP-HP, Hôpital Necker Enfants MaladesParisFRA1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.11 aut.12 aut.13 aut.Arnold MunnichDepartment of Genetics, INSERM U 781, Université Paris Descartes, AP-HP, Hôpital Necker Enfants MaladesParisFRA1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.11 aut.12 aut.13 aut.Valerie Cormier-DaireDepartment of Genetics, INSERM U 781, Université Paris Descartes, AP-HP, Hôpital Necker Enfants MaladesParisFRA1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.11 aut.12 aut.13 aut.11-01038552011PASCAL 11-0103855 INISTPascal:11-01038550012770022-2593J. med. genet.Journal of medical geneticsDysplasiaFetusGeneticsHumanMutationPhenotypeSpectrumDysplasieMutationFoetusPhénotypeSpectreGénétiqueHomme
Background The lethal group of short-rib polydactyly (SRP) includes type I (Saldino-Noonan; MIM 263530), type II (Majewski; MIM 263520), type III (Verma-Naumoff; MIM 263510) and type IV (Beemer-Langer; MIM 269860). Jeune and Ellis-van Creveld dysplasias also used to be classified in the SRP group. Recently, mutations in a gene encoding a protein involved in intraflagellar transport, IFT80, have been identified in 3/39 patients with Jeune dysplasia but no extraskeletal manifestation. Methods Because of clinical and radiological similarities between Jeune dysplasia and the other lethal types of SRP, the authors decided to investigate IFT80 in a cohort of fetuses with the lethal forms of SRP (Majewski, Verma-Naumoff and Beemer-Langer) and antenatally diagnosed cases of Jeune dysplasia. Fifteen fetuses were identified. A double-molecular approach was adopted. For consanguineous families and for those with recurrent sibs, a haplotype analysis around the gene locus was first performed, and, for the others, all the coding exons of IFT80 were directly sequenced. Results Using the haplotype approach for two families, the authors excluded the IFT80 region as a candidate for them. Direct sequencing of IFT80 in the other 13 cases showed a G-to-C transversion in exon 8 (G241 R) in only one SRP case closely related to the type III phenotype. Conclusions The findings show that mutations in IFT80 can also be responsible for a lethal form of SRP and provide the molecular basis for the Jeune-Verma-Naumoff dysplasia spectrum.
0022-2593JMDGAEJ. med. genet.482Mutation in IFT80 in a fetus with the phenotype of Verma-Naumoff provides molecular evidence for Jeune-Verma-Naumoff dysplasia spectrumCAVALCANTI (Denise P.)HUBER (Celine)LE QUAN SANG (Kim-Hanh)BAUJAT (Geneviève)COLLINS (Felicity)DELEZOIDE (Anne-Lise)DAGONEAU (Nathalie)LE MERRER (Martine)MARTINOVIC (Jelena)MELLO (Marcos Fernando S.)VEKEMANS (Michel)MUNNICH (Arnold)CORMIER-DAIRE (Valerie)Perinatal Genetic Program, Department of Medical Genetic, FCM, UNICAMPCampinas, São PauloBRA1 aut.Department of Genetics, INSERM U 781, Université Paris Descartes, AP-HP, Hôpital Necker Enfants MaladesParisFRA1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.11 aut.12 aut.13 aut.Western Sydney Genetics Program, Department of Clinical Genetics, Children's Hospital at WestmeadSydneyAUS5 aut.Service de Biologie de Développement, Université Paris Diderot, Hôpital Robert DebréParisFRA6 aut.Unit of Fetal Pathology, Department of Histo-Embryology and Cytogenetics, Hôpital Necker-Enfants MaladesParisFRA9 aut.Department of Pathology, FCM, UNICAMPCampinas, São PauloBRA10 aut.88-922011ENGINIST121253540001943296300200000© 2011 INIST-CNRS. All rights reserved.28 ref.11-0103855PAJournal of medical geneticsGBRBackground The lethal group of short-rib polydactyly (SRP) includes type I (Saldino-Noonan; MIM 263530), type II (Majewski; MIM 263520), type III (Verma-Naumoff; MIM 263510) and type IV (Beemer-Langer; MIM 269860). Jeune and Ellis-van Creveld dysplasias also used to be classified in the SRP group. Recently, mutations in a gene encoding a protein involved in intraflagellar transport, IFT80, have been identified in 3/39 patients with Jeune dysplasia but no extraskeletal manifestation. Methods Because of clinical and radiological similarities between Jeune dysplasia and the other lethal types of SRP, the authors decided to investigate IFT80 in a cohort of fetuses with the lethal forms of SRP (Majewski, Verma-Naumoff and Beemer-Langer) and antenatally diagnosed cases of Jeune dysplasia. Fifteen fetuses were identified. A double-molecular approach was adopted. For consanguineous families and for those with recurrent sibs, a haplotype analysis around the gene locus was first performed, and, for the others, all the coding exons of IFT80 were directly sequenced. Results Using the haplotype approach for two families, the authors excluded the IFT80 region as a candidate for them. Direct sequencing of IFT80 in the other 13 cases showed a G-to-C transversion in exon 8 (G241 R) in only one SRP case closely related to the type III phenotype. Conclusions The findings show that mutations in IFT80 can also be responsible for a lethal form of SRP and provide the molecular basis for the Jeune-Verma-Naumoff dysplasia spectrum.002A04002A07002B23ADysplasie01Dysplasia01Displasia01Mutation09Mutation09Mutación09Foetus10Fetus10Feto10Phénotype11Phenotype11Fenotipo11Spectre12Spectrum12Espectro12Génétique13Genetics13Genética13Homme14Human14Hombre14066OTOOTOPASCAL 11-0103855 INISTMutation in IFT80 in a fetus with the phenotype of Verma-Naumoff provides molecular evidence for Jeune-Verma-Naumoff dysplasia spectrumCAVALCANTI (Denise P.); HUBER (Celine); LE QUAN SANG (Kim-Hanh); BAUJAT (Geneviève); COLLINS (Felicity); DELEZOIDE (Anne-Lise); DAGONEAU (Nathalie); LE MERRER (Martine); MARTINOVIC (Jelena); MELLO (Marcos Fernando S.); VEKEMANS (Michel); MUNNICH (Arnold); CORMIER-DAIRE (Valerie)Perinatal Genetic Program, Department of Medical Genetic, FCM, UNICAMP/Campinas, São Paulo/Brésil (1 aut.); Department of Genetics, INSERM U 781, Université Paris Descartes, AP-HP, Hôpital Necker Enfants Malades/Paris/France (1 aut., 2 aut., 3 aut., 4 aut., 7 aut., 8 aut., 11 aut., 12 aut., 13 aut.); Western Sydney Genetics Program, Department of Clinical Genetics, Children's Hospital at Westmead/Sydney/Australie (5 aut.); Service de Biologie de Développement, Université Paris Diderot, Hôpital Robert Debré/Paris/France (6 aut.); Unit of Fetal Pathology, Department of Histo-Embryology and Cytogenetics, Hôpital Necker-Enfants Malades/Paris/France (9 aut.); Department of Pathology, FCM, UNICAMP/Campinas, São Paulo/Brésil (10 aut.)
Publication en série; Niveau analytique
Journal of medical genetics; ISSN 0022-2593; Coden JMDGAE; Royaume-Uni; Da. 2011; Vol. 48; No. 2; Pp. 88-92; Bibl. 28 ref.AnglaisBackground The lethal group of short-rib polydactyly (SRP) includes type I (Saldino-Noonan; MIM 263530), type II (Majewski; MIM 263520), type III (Verma-Naumoff; MIM 263510) and type IV (Beemer-Langer; MIM 269860). Jeune and Ellis-van Creveld dysplasias also used to be classified in the SRP group. Recently, mutations in a gene encoding a protein involved in intraflagellar transport, IFT80, have been identified in 3/39 patients with Jeune dysplasia but no extraskeletal manifestation. Methods Because of clinical and radiological similarities between Jeune dysplasia and the other lethal types of SRP, the authors decided to investigate IFT80 in a cohort of fetuses with the lethal forms of SRP (Majewski, Verma-Naumoff and Beemer-Langer) and antenatally diagnosed cases of Jeune dysplasia. Fifteen fetuses were identified. A double-molecular approach was adopted. For consanguineous families and for those with recurrent sibs, a haplotype analysis around the gene locus was first performed, and, for the others, all the coding exons of IFT80 were directly sequenced. Results Using the haplotype approach for two families, the authors excluded the IFT80 region as a candidate for them. Direct sequencing of IFT80 in the other 13 cases showed a G-to-C transversion in exon 8 (G241 R) in only one SRP case closely related to the type III phenotype. Conclusions The findings show that mutations in IFT80 can also be responsible for a lethal form of SRP and provide the molecular basis for the Jeune-Verma-Naumoff dysplasia spectrum.002A04; 002A07; 002B23ADysplasie; Mutation; Foetus; Phénotype; Spectre; Génétique; HommeDysplasia; Mutation; Fetus; Phenotype; Spectrum; Genetics; HumanDisplasia; Mutación; Feto; Fenotipo; Espectro; Genética; HombreINIST-12125.35400019432963002011-0103855 001621 Neuropharmacological basis of rTMS-induced analgesia: The role of endogenous opioidsDaniel Ciampi De AndradeINSERM U-987, Centre d'Evaluation et de Traitement de la Douleur, Ambroise ParéBoulogne-BillancourtFRA1 aut.2 aut.3 aut.5 aut.Department of Neurology, Hospital das Clinicas, University of São PauloBRA1 aut.4 aut.Alaa MhallaINSERM U-987, Centre d'Evaluation et de Traitement de la Douleur, Ambroise ParéBoulogne-BillancourtFRA1 aut.2 aut.3 aut.5 aut.Frédéric AdamINSERM U-987, Centre d'Evaluation et de Traitement de la Douleur, Ambroise ParéBoulogne-BillancourtFRA1 aut.2 aut.3 aut.5 aut.Manoel Jacobsen TexeiraDepartment of Neurology, Hospital das Clinicas, University of São PauloBRA1 aut.4 aut.Didier BouhassiraINSERM U-987, Centre d'Evaluation et de Traitement de la Douleur, Ambroise ParéBoulogne-BillancourtFRA1 aut.2 aut.3 aut.5 aut.11-01040242011PASCAL 11-0104024 INISTPascal:11-01040240012760304-3959Pain : (Amst.)Pain : (Amsterdam)AnalgesiaAnalgesicBolus injectionColdMotor cortexNaloxonePainPlaceboRepetitive stimulusTemperatureTranscranial magnetic stimulationTreatmentAnalgésieAnalgésiqueStimulus répétitifStimulation magnétique transcrânienneCortex moteurNaloxonePlaceboTraitementFroidDouleurTempératureInjection bolus
We investigated the role of endogenous opioid systems in the analgesic effects induced by repetitive transcranial magnetic stimulation (rTMS). We compared the analgesic effects of motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) stimulation before and after naloxone or placebo treatment, in a randomized, double-blind crossover design, in healthy volunteers. Three groups of 12 volunteers were selected at random and given active stimulation (frequency 10 Hz, at 80% motor threshold intensity, 1500 pulses per session) of the right M1, active stimulation of the right DLPFC, or sham stimulation, during two experimental sessions 2 weeks apart. Cold pain thresholds and the intensity of pain induced by a series of fixed-temperature cold stimuli (5, 10, and 15 °C) were used to evaluate the analgesic effects of rTMS. Measurements were made at the left thenar eminence, before and 1 hour after the intravenous injection of naloxone (bolus of 0.1 mg/kg followed by a continuous infusion of 0.1 mg/kg/h until the end of rTMS) or placebo (saline). Naloxone injection significantly decreased the analgesic effects of M1 stimulation, but did not change the effects of rTMS of the DLPFC or sham rTMS. This study demonstrates, for the first time, the involvement of endogenous opioid systems in rTMS-induced analgesia. The differential effects of naloxone on M1 and DLPFC stimulation suggest that the analgesic effects induced by the stimulation of these 2 cortical sites are mediated by different mechanisms.
0304-3959PAINDBPain : (Amst.)1522Neuropharmacological basis of rTMS-induced analgesia: The role of endogenous opioidsCIAMPI DE ANDRADE (Daniel)MHALLA (Alaa)ADAM (Frédéric)TEXEIRA (Manoel Jacobsen)BOUHASSIRA (Didier)INSERM U-987, Centre d'Evaluation et de Traitement de la Douleur, Ambroise ParéBoulogne-BillancourtFRA1 aut.2 aut.3 aut.5 aut.Department of Neurology, Hospital das Clinicas, University of São PauloBRA1 aut.4 aut.320-3262011ENGINIST172413540001943444901700000© 2011 INIST-CNRS. All rights reserved.70 ref.11-0104024PPRAPain : (Amsterdam)NLDWe investigated the role of endogenous opioid systems in the analgesic effects induced by repetitive transcranial magnetic stimulation (rTMS). We compared the analgesic effects of motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) stimulation before and after naloxone or placebo treatment, in a randomized, double-blind crossover design, in healthy volunteers. Three groups of 12 volunteers were selected at random and given active stimulation (frequency 10 Hz, at 80% motor threshold intensity, 1500 pulses per session) of the right M1, active stimulation of the right DLPFC, or sham stimulation, during two experimental sessions 2 weeks apart. Cold pain thresholds and the intensity of pain induced by a series of fixed-temperature cold stimuli (5, 10, and 15 °C) were used to evaluate the analgesic effects of rTMS. Measurements were made at the left thenar eminence, before and 1 hour after the intravenous injection of naloxone (bolus of 0.1 mg/kg followed by a continuous infusion of 0.1 mg/kg/h until the end of rTMS) or placebo (saline). Naloxone injection significantly decreased the analgesic effects of M1 stimulation, but did not change the effects of rTMS of the DLPFC or sham rTMS. This study demonstrates, for the first time, the involvement of endogenous opioid systems in rTMS-induced analgesia. The differential effects of naloxone on M1 and DLPFC stimulation suggest that the analgesic effects induced by the stimulation of these 2 cortical sites are mediated by different mechanisms.002B02B05002A25FAnalgésie01Analgesia01Analgesia01Analgésique02Analgesic02Analgésico02Stimulus répétitif03Repetitive stimulus03Estímulo repetitivo03Stimulation magnétique transcrânienne04Transcranial magnetic stimulation04Estimulación magnética transcraneal04Cortex moteur05Motor cortex05Corteza motora05NaloxoneNKFR06NaloxoneNKFR06NaloxonaNKFR06Placebo07Placebo07Placebo07Traitement08Treatment08Tratamiento08Froid10Cold10Frío10Douleur11Pain11Dolor11Température13Temperature13Temperatura13Injection bolus14Bolus injection14Inyección bolo14Encéphale20Encephalon20Encéfalo20Système nerveux central21Central nervous system21Sistema nervioso central21Voie motrice22Motor pathway22Vía motora22Facteur milieu23Environmental factor23Factor medio23066OTOOTOPASCAL 11-0104024 INISTNeuropharmacological basis of rTMS-induced analgesia: The role of endogenous opioidsCIAMPI DE ANDRADE (Daniel); MHALLA (Alaa); ADAM (Frédéric); TEXEIRA (Manoel Jacobsen); BOUHASSIRA (Didier)INSERM U-987, Centre d'Evaluation et de Traitement de la Douleur, Ambroise Paré/Boulogne-Billancourt/France (1 aut., 2 aut., 3 aut., 5 aut.); Department of Neurology, Hospital das Clinicas, University of São Paulo/Brésil (1 aut., 4 aut.)
Publication en série; Papier de recherche; Niveau analytique
Pain : (Amsterdam); ISSN 0304-3959; Coden PAINDB; Pays-Bas; Da. 2011; Vol. 152; No. 2; Pp. 320-326; Bibl. 70 ref.AnglaisWe investigated the role of endogenous opioid systems in the analgesic effects induced by repetitive transcranial magnetic stimulation (rTMS). We compared the analgesic effects of motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) stimulation before and after naloxone or placebo treatment, in a randomized, double-blind crossover design, in healthy volunteers. Three groups of 12 volunteers were selected at random and given active stimulation (frequency 10 Hz, at 80% motor threshold intensity, 1500 pulses per session) of the right M1, active stimulation of the right DLPFC, or sham stimulation, during two experimental sessions 2 weeks apart. Cold pain thresholds and the intensity of pain induced by a series of fixed-temperature cold stimuli (5, 10, and 15 °C) were used to evaluate the analgesic effects of rTMS. Measurements were made at the left thenar eminence, before and 1 hour after the intravenous injection of naloxone (bolus of 0.1 mg/kg followed by a continuous infusion of 0.1 mg/kg/h until the end of rTMS) or placebo (saline). Naloxone injection significantly decreased the analgesic effects of M1 stimulation, but did not change the effects of rTMS of the DLPFC or sham rTMS. This study demonstrates, for the first time, the involvement of endogenous opioid systems in rTMS-induced analgesia. The differential effects of naloxone on M1 and DLPFC stimulation suggest that the analgesic effects induced by the stimulation of these 2 cortical sites are mediated by different mechanisms.002B02B05; 002A25FAnalgésie; Analgésique; Stimulus répétitif; Stimulation magnétique transcrânienne; Cortex moteur; Naloxone; Placebo; Traitement; Froid; Douleur; Température; Injection bolusEncéphale; Système nerveux central; Voie motrice; Facteur milieuAnalgesia; Analgesic; Repetitive stimulus; Transcranial magnetic stimulation; Motor cortex; Naloxone; Placebo; Treatment; Cold; Pain; Temperature; Bolus injectionEncephalon; Central nervous system; Motor pathway; Environmental factorAnalgesia; Analgésico; Estímulo repetitivo; Estimulación magnética transcraneal; Corteza motora; Naloxona; Placebo; Tratamiento; Frío; Dolor; Temperatura; Inyección boloINIST-17241.35400019434449017011-0104024 001622 Coastal bacterioplankton community diversity along a latitudinal gradient in Latin America by means of V6 tag pyrosequencingFabiano L. ThompsonDepartments of Genetics, Institute of Biology, Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBRA1 aut.2 aut.Thiago BruceDepartments of Genetics, Institute of Biology, Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBRA1 aut.2 aut.Alessandra GonzalezDepartments of Marine Biology, Institute of Biology, Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBRA3 aut.16 aut.Alexander CardosoInstitute of Medical Biochemistry, Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBRA4 aut.15 aut.Maysa ClementinoInstitute of Quality Control in Health, Department of Microbiology FIOCRUZRio de JaneiroBRA5 aut.Marcela CostagliolaInstituto Nacional de Investigación y Desarrollo Pesquero (INIDEP)Mar del PlataARG6 aut.7 aut.10 aut.Constanza HozborInstituto Nacional de Investigación y Desarrollo Pesquero (INIDEP)Mar del PlataARG6 aut.7 aut.10 aut.Ernesto OteroDepartamento de Ciencias Marinas, Universidad de Puerto RicoMayagüez, PRUSA8 aut.13 aut.Claudia PicciniDepartamento de Microbiología, Instituto de Investigaciones Biológicas Clemente Estable, Avenida Italia 331811600 MontevideoURY9 aut.Silvia PeressuttiInstituto Nacional de Investigación y Desarrollo Pesquero (INIDEP)Mar del PlataARG6 aut.7 aut.10 aut.Robert SchmiederDepartment of Computer Science and Computational Science Research Center, San Diego State UniversitySan Diego, CAUSA11 aut.12 aut.Robert EdwardsDepartment of Computer Science and Computational Science Research Center, San Diego State UniversitySan Diego, CAUSA11 aut.12 aut.Mathew SmithDepartamento de Ciencias Marinas, Universidad de Puerto RicoMayagüez, PRUSA8 aut.13 aut.Luis Roberto TakiyamaCentro de Pesquisas Aquáticas (CPAq), Instituto Estadual de Pesquisas do Amapá (IEPA)Macapá, APBRA14 aut.Ricardo VieiraInstitute of Medical Biochemistry, Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBRA4 aut.15 aut.Rodolfo ParanhosDepartments of Marine Biology, Institute of Biology, Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBRA3 aut.16 aut.Luis Felipe ArtigasUniversité Lille Nord de France, ULCO Laboratoire d'Océanologie et Géosciences (LOG), CNRS UMR8187 WimereuxFRA17 aut.11-01051742011PASCAL 11-0105174 INISTPascal:11-01051740012750302-8933Arch. microbiol.Archives of microbiologyBacterioplanktonCoastal zoneLatin AmericaMarine environmentSpecies diversityZone côtièreBactérioplanctonAmérique LatineMilieu marinDiversité espèces
The bacterioplankton diversity of coastal waters along a latitudinal gradient between Puerto Rico and Argentina was analyzed using a total of 134,197 high-quality sequences from the V6 hypervariable region of the small-subunit ribosomal RNA gene (16S rRNA) (mean length of 60 nt). Most of the OTUs were identified into Proteobacteria, Bacteriodetes, Cyanobacteria, and Actino-bacteria, corresponding to approx. 80% of the total number of sequences. The number of OTUs corresponding to species varied between 937 and 1946 in the seven locations. Proteobacteria appeared at high frequency in the seven locations. An enrichment of Cyanobacteria was observed in Puerto Rico, whereas an enrichment of Bacteroidetes was detected in the Argentinian shelf and Uruguayan coastal lagoons. The highest number of sequences of Actinobacteria and Acidobacteria were obtained in the Amazon estuary mouth. The rarefaction curves and Good coverage estimator for species diversity suggested a significant coverage, with values ranging between 92 and 97% for Good coverage. Conserved taxa corresponded to aprox. 52% of all sequences. This study suggests that human-contaminated environments may influence bacterioplankton diversity.
0302-8933AMICCWArch. microbiol.1932Coastal bacterioplankton community diversity along a latitudinal gradient in Latin America by means of V6 tag pyrosequencingTHOMPSON (Fabiano L.)BRUCE (Thiago)GONZALEZ (Alessandra)CARDOSO (Alexander)CLEMENTINO (Maysa)COSTAGLIOLA (Marcela)HOZBOR (Constanza)OTERO (Ernesto)PICCINI (Claudia)PERESSUTTI (Silvia)SCHMIEDER (Robert)EDWARDS (Robert)SMITH (Mathew)TAKIYAMA (Luis Roberto)VIEIRA (Ricardo)PARANHOS (Rodolfo)FELIPE ARTIGAS (Luis)Departments of Genetics, Institute of Biology, Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBRA1 aut.2 aut.Departments of Marine Biology, Institute of Biology, Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBRA3 aut.16 aut.Institute of Medical Biochemistry, Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBRA4 aut.15 aut.Institute of Quality Control in Health, Department of Microbiology FIOCRUZRio de JaneiroBRA5 aut.Department of Computer Science and Computational Science Research Center, San Diego State UniversitySan Diego, CAUSA11 aut.12 aut.Instituto Nacional de Investigación y Desarrollo Pesquero (INIDEP)Mar del PlataARG6 aut.7 aut.10 aut.Departamento de Ciencias Marinas, Universidad de Puerto RicoMayagüez, PRUSA8 aut.13 aut.Departamento de Microbiología, Instituto de Investigaciones Biológicas Clemente Estable, Avenida Italia 331811600 MontevideoURY9 aut.Centro de Pesquisas Aquáticas (CPAq), Instituto Estadual de Pesquisas do Amapá (IEPA)Macapá, APBRA14 aut.Université Lille Nord de France, ULCO Laboratoire d'Océanologie et Géosciences (LOG), CNRS UMR8187 WimereuxFRA17 aut.105-1142011ENGINIST8563540001943254200500000© 2011 INIST-CNRS. All rights reserved.1 p.11-0105174PAArchives of microbiologyDEUThe bacterioplankton diversity of coastal waters along a latitudinal gradient between Puerto Rico and Argentina was analyzed using a total of 134,197 high-quality sequences from the V6 hypervariable region of the small-subunit ribosomal RNA gene (16S rRNA) (mean length of 60 nt). Most of the OTUs were identified into Proteobacteria, Bacteriodetes, Cyanobacteria, and Actino-bacteria, corresponding to approx. 80% of the total number of sequences. The number of OTUs corresponding to species varied between 937 and 1946 in the seven locations. Proteobacteria appeared at high frequency in the seven locations. An enrichment of Cyanobacteria was observed in Puerto Rico, whereas an enrichment of Bacteroidetes was detected in the Argentinian shelf and Uruguayan coastal lagoons. The highest number of sequences of Actinobacteria and Acidobacteria were obtained in the Amazon estuary mouth. The rarefaction curves and Good coverage estimator for species diversity suggested a significant coverage, with values ranging between 92 and 97% for Good coverage. Conserved taxa corresponded to aprox. 52% of all sequences. This study suggests that human-contaminated environments may influence bacterioplankton diversity.002A05002A14C02Zone côtière05Coastal zone05Zona costera05Bactérioplancton06Bacterioplankton06Bacterioplanctón06Amérique LatineNG07Latin AmericaNG07America latinaNG07Milieu marin08Marine environment08Medio marino08Diversité espèces09Species diversity09Diversidad especies09AmériqueNGAmericaNGAmericaNG066OTOOTOPASCAL 11-0105174 INISTCoastal bacterioplankton community diversity along a latitudinal gradient in Latin America by means of V6 tag pyrosequencingTHOMPSON (Fabiano L.); BRUCE (Thiago); GONZALEZ (Alessandra); CARDOSO (Alexander); CLEMENTINO (Maysa); COSTAGLIOLA (Marcela); HOZBOR (Constanza); OTERO (Ernesto); PICCINI (Claudia); PERESSUTTI (Silvia); SCHMIEDER (Robert); EDWARDS (Robert); SMITH (Mathew); TAKIYAMA (Luis Roberto); VIEIRA (Ricardo); PARANHOS (Rodolfo); FELIPE ARTIGAS (Luis)Departments of Genetics, Institute of Biology, Federal University of Rio de Janeiro (UFRJ)/Rio de Janeiro/Brésil (1 aut., 2 aut.); Departments of Marine Biology, Institute of Biology, Federal University of Rio de Janeiro (UFRJ)/Rio de Janeiro/Brésil (3 aut., 16 aut.); Institute of Medical Biochemistry, Federal University of Rio de Janeiro (UFRJ)/Rio de Janeiro/Brésil (4 aut., 15 aut.); Institute of Quality Control in Health, Department of Microbiology FIOCRUZ/Rio de Janeiro/Brésil (5 aut.); Department of Computer Science and Computational Science Research Center, San Diego State University/San Diego, CA/Etats-Unis (11 aut., 12 aut.); Instituto Nacional de Investigación y Desarrollo Pesquero (INIDEP)/Mar del Plata/Argentine (6 aut., 7 aut., 10 aut.); Departamento de Ciencias Marinas, Universidad de Puerto Rico/Mayagüez, PR/Etats-Unis (8 aut., 13 aut.); Departamento de Microbiología, Instituto de Investigaciones Biológicas Clemente Estable, Avenida Italia 3318/11600 Montevideo/Uruguay (9 aut.); Centro de Pesquisas Aquáticas (CPAq), Instituto Estadual de Pesquisas do Amapá (IEPA)/Macapá, AP/Brésil (14 aut.); Université Lille Nord de France, ULCO Laboratoire d'Océanologie et Géosciences (LOG), CNRS UMR/8187 Wimereux/France (17 aut.)
Publication en série; Niveau analytique
Archives of microbiology; ISSN 0302-8933; Coden AMICCW; Allemagne; Da. 2011; Vol. 193; No. 2; Pp. 105-114; Bibl. 1 p.AnglaisThe bacterioplankton diversity of coastal waters along a latitudinal gradient between Puerto Rico and Argentina was analyzed using a total of 134,197 high-quality sequences from the V6 hypervariable region of the small-subunit ribosomal RNA gene (16S rRNA) (mean length of 60 nt). Most of the OTUs were identified into Proteobacteria, Bacteriodetes, Cyanobacteria, and Actino-bacteria, corresponding to approx. 80% of the total number of sequences. The number of OTUs corresponding to species varied between 937 and 1946 in the seven locations. Proteobacteria appeared at high frequency in the seven locations. An enrichment of Cyanobacteria was observed in Puerto Rico, whereas an enrichment of Bacteroidetes was detected in the Argentinian shelf and Uruguayan coastal lagoons. The highest number of sequences of Actinobacteria and Acidobacteria were obtained in the Amazon estuary mouth. The rarefaction curves and Good coverage estimator for species diversity suggested a significant coverage, with values ranging between 92 and 97% for Good coverage. Conserved taxa corresponded to aprox. 52% of all sequences. This study suggests that human-contaminated environments may influence bacterioplankton diversity.002A05; 002A14C02Zone côtière; Bactérioplancton; Amérique Latine; Milieu marin; Diversité espècesAmériqueCoastal zone; Bacterioplankton; Latin America; Marine environment; Species diversityAmericaZona costera; Bacterioplanctón; America latina; Medio marino; Diversidad especiesINIST-856.35400019432542005011-0105174 001623 Mass-splittings of doubly heavy baryons in QCDR. M. AlbuquerqueInstituto de Fisica, Universidade de Sdo Paulo, C.P. 6631805389-970 São Paulo, SPBRA1 aut.Laboratoire de Physique Théorique et Astroporticules, CNRS-IN2P3 & Université de Montpellier II, Case 070, Place Eugène Bataillon34095 MontpellierFRA1 aut.2 aut.S. NarisonLaboratoire de Physique Théorique et Astroporticules, CNRS-IN2P3 & Université de Montpellier II, Case 070, Place Eugène Bataillon34095 MontpellierFRA1 aut.2 aut.11-01055842010PASCAL 11-0105584 INISTPascal:11-01055840012740370-2693Phys. lett., Sect. BPhysics letters. Section BBaryon massBaryon spinBaryonsCorrelatorsElectromagnetic decaysElementary particle massHadron massModelsQuantum chromodynamicsRadiative correctionsSU(2) theorySU(3) theorySum rulesBaryonChromodynamique quantiqueSpin baryonMasse baryoniqueThéorie SU(2)Théorie SU(3)Règle sommeMasse hadronModèleCorrection radiativeCorrélateurDésintégration électromagnétiqueMasse particule élémentaire
We consider (for the first time) the ratios of doubly heavy baryon masses (spin 3/2 over spin 1/2 and SU(3) mass-splittings) using double ratios of sum rules (DRSR), which are more accurate than the usual simple ratios often used in the literature for getting the hadron masses. In general, our results agree and compete in precision with potential model predictions. In our approach, the αs corrections induced by the anomalous dimensions of the correlators are the main sources of the ========Xgr;*QQ-========Xgr;QQ mass-splittings, which seem to indicate a 1/MQ behaviour and can only allow the electromagnetic decay ========Xgr;*QQ → ========Xgr;QQ + y but not to ========Xgr;QQ + π. Our results also show that the SU(3) mass-splittings are (almost) independent of the spin of the baryons and behave approximately like 1/MQ, which could be understood from the QCD expressions of the corresponding two-point correlator. Our results can improved by including radiative corrections to the SU(3) breaking terms and can be tested, in the near future, at Tevatron and LHCb.
0370-2693PYLBAJPhys. lett., Sect. B6943Mass-splittings of doubly heavy baryons in QCDALBUQUERQUE (R. M.)NARISON (S.)Instituto de Fisica, Universidade de Sdo Paulo, C.P. 6631805389-970 São Paulo, SPBRA1 aut.Laboratoire de Physique Théorique et Astroporticules, CNRS-IN2P3 & Université de Montpellier II, Case 070, Place Eugène Bataillon34095 MontpellierFRA1 aut.2 aut.217-2252010ENGINIST9425B3540001943341700700000© 2011 INIST-CNRS. All rights reserved.42 ref.11-0105584PAPhysics letters. Section BGBRWe consider (for the first time) the ratios of doubly heavy baryon masses (spin 3/2 over spin 1/2 and SU(3) mass-splittings) using double ratios of sum rules (DRSR), which are more accurate than the usual simple ratios often used in the literature for getting the hadron masses. In general, our results agree and compete in precision with potential model predictions. In our approach, the αs corrections induced by the anomalous dimensions of the correlators are the main sources of the ========Xgr;*QQ-========Xgr;QQ mass-splittings, which seem to indicate a 1/MQ behaviour and can only allow the electromagnetic decay ========Xgr;*QQ → ========Xgr;QQ + y but not to ========Xgr;QQ + π. Our results also show that the SU(3) mass-splittings are (almost) independent of the spin of the baryons and behave approximately like 1/MQ, which could be understood from the QCD expressions of the corresponding two-point correlator. Our results can improved by including radiative corrections to the SU(3) breaking terms and can be tested, in the near future, at Tevatron and LHCb.001B00001B20001B10Baryon26Baryons26Chromodynamique quantique27Quantum chromodynamics27Spin baryon28Baryon spin28Masse baryonique29Baryon mass29Théorie SU(2)30SU(2) theory30Théorie SU(3)31SU(3) theory31Règle somme32Sum rules32Masse hadron33Hadron mass33Modèle34Models34Modelo34Correction radiative35Radiative corrections35Corrélateur36Correlators36Désintégration électromagnétique37Electromagnetic decays37Masse particule élémentaire38Elementary particle mass38066OTOOTOPASCAL 11-0105584 INISTMass-splittings of doubly heavy baryons in QCDALBUQUERQUE (R. M.); NARISON (S.)Instituto de Fisica, Universidade de Sdo Paulo, C.P. 66318/05389-970 São Paulo, SP/Brésil (1 aut.); Laboratoire de Physique Théorique et Astroporticules, CNRS-IN2P3 & Université de Montpellier II, Case 070, Place Eugène Bataillon/34095 Montpellier/France (1 aut., 2 aut.)
Publication en série; Niveau analytique
Physics letters. Section B; ISSN 0370-2693; Coden PYLBAJ; Royaume-Uni; Da. 2010; Vol. 694; No. 3; Pp. 217-225; Bibl. 42 ref.AnglaisWe consider (for the first time) the ratios of doubly heavy baryon masses (spin 3/2 over spin 1/2 and SU(3) mass-splittings) using double ratios of sum rules (DRSR), which are more accurate than the usual simple ratios often used in the literature for getting the hadron masses. In general, our results agree and compete in precision with potential model predictions. In our approach, the αs corrections induced by the anomalous dimensions of the correlators are the main sources of the ========Xgr;*QQ-========Xgr;QQ mass-splittings, which seem to indicate a 1/MQ behaviour and can only allow the electromagnetic decay ========Xgr;*QQ → ========Xgr;QQ + y but not to ========Xgr;QQ + π. Our results also show that the SU(3) mass-splittings are (almost) independent of the spin of the baryons and behave approximately like 1/MQ, which could be understood from the QCD expressions of the corresponding two-point correlator. Our results can improved by including radiative corrections to the SU(3) breaking terms and can be tested, in the near future, at Tevatron and LHCb.001B00; 001B20; 001B10Baryon; Chromodynamique quantique; Spin baryon; Masse baryonique; Théorie SU(2); Théorie SU(3); Règle somme; Masse hadron; Modèle; Correction radiative; Corrélateur; Désintégration électromagnétique; Masse particule élémentaireBaryons; Quantum chromodynamics; Baryon spin; Baryon mass; SU(2) theory; SU(3) theory; Sum rules; Hadron mass; Models; Radiative corrections; Correlators; Electromagnetic decays; Elementary particle massModeloINIST-9425B.35400019433417007011-0105584 001624 How Learning to Read Changes the Cortical Networks for Vision and LanguageStanislas DehaeneINSERM, Cognitive Neuroimaging UnitGif sur Yvette 91191FRA1 aut.2 aut.6 aut.7 aut.Commissariat à l'Energie Atomique, Direction des Sciences du Vivant, 12BM, Neurospin centerGif sur Yvette 91191FRA1 aut.2 aut.6 aut.7 aut.University Paris-Sud 1191405 OrsayFRA1 aut.2 aut.6 aut.7 aut.College de France, 11 Place Marcelin Berthelot75005 ParisFRA1 aut.Felipe PegadoINSERM, Cognitive Neuroimaging UnitGif sur Yvette 91191FRA1 aut.2 aut.6 aut.7 aut.Commissariat à l'Energie Atomique, Direction des Sciences du Vivant, 12BM, Neurospin centerGif sur Yvette 91191FRA1 aut.2 aut.6 aut.7 aut.University Paris-Sud 1191405 OrsayFRA1 aut.2 aut.6 aut.7 aut.Lucia W. BragaSARAH Network-International Center for Neurosciences and Rehabilitation, QL 13, Lago Norte71.535-005 Brasilia, DFBRA3 aut.5 aut.Paulo VenturaFaculty of Psychology, University of Lisbon1600-214 LisbonPRT4 aut.Gilberto Nunes FilhoSARAH Network-International Center for Neurosciences and Rehabilitation, QL 13, Lago Norte71.535-005 Brasilia, DFBRA3 aut.5 aut.Antoinette JobertINSERM, Cognitive Neuroimaging UnitGif sur Yvette 91191FRA1 aut.2 aut.6 aut.7 aut.Commissariat à l'Energie Atomique, Direction des Sciences du Vivant, 12BM, Neurospin centerGif sur Yvette 91191FRA1 aut.2 aut.6 aut.7 aut.University Paris-Sud 1191405 OrsayFRA1 aut.2 aut.6 aut.7 aut.Ghislaine Dehaene-LambertzINSERM, Cognitive Neuroimaging UnitGif sur Yvette 91191FRA1 aut.2 aut.6 aut.7 aut.Commissariat à l'Energie Atomique, Direction des Sciences du Vivant, 12BM, Neurospin centerGif sur Yvette 91191FRA1 aut.2 aut.6 aut.7 aut.University Paris-Sud 1191405 OrsayFRA1 aut.2 aut.6 aut.7 aut.Régine KolinskyFaculty of Psychology, Université Libre de Bruxelles (ULB)1050 BrusselsBEL8 aut.9 aut.Fonds de la Recherche Scientifique (FNRS)1000 BrusselsBEL8 aut.José MoraisFaculty of Psychology, Université Libre de Bruxelles (ULB)1050 BrusselsBEL8 aut.9 aut.Laurent CohenUniversité Pierre et Marie Curie-Paris 6, Faculté de Médecine Pitié-Salpêtrière75013 ParisFRA10 aut.Assistance Publique-Hôpitaux de Paris, Groupe hospitalier Pitié-Salpêtrière, Department of Neurology75651 ParisFRA10 aut.INSERM, Centre de Recherches de l'Institut du cerveau et de la moelle épinière, UMRS 975ParisFRA10 aut.11-01071752010PASCAL 11-0107175 INISTPascal:11-0107175001273FRANCIS 11-0107175 INIST0036-8075Science : (Wash. D.C.)Science : (Washington, D.C.)AdultChildFaceFunctional imagingFusiform gyrusHand writingLanguageLiteracyNuclear magnetic resonance imagingOccipital cortexOrthographyPhonologyPlanum temporaleReadingSpeechToolVisionVisual cortexVisual stimulusImagerie fonctionnelleImagerie RMNVisionLangageGyrus fusiformeCortex occipitalCortex visuelPlanum temporaleAlphabétismeParoleEcritureLectureStimulus visuelFaceOutilPhonologieOrthographeEnfantAdulte
Does literacy improve brain function? Does it also entail losses? Using functional magnetic resonance imaging, we measured brain responses to spoken and written language, visual faces, houses, tools, and checkers in adults of variable literacy (10 were illiterate, 22 became literate as adults, and 31 were literate in childhood). As literacy enhanced the left fusiform activation evoked by writing, it induced a small competition with faces at this location, but also broadly enhanced visual responses in fusiform and occipital cortex, extending to area V1. Literacy also enhanced phonological activation to speech in the planum temporale and afforded a top-down activation of orthography from spoken inputs. Most changes occurred even when literacy was acquired in adulthood, emphasizing that both childhood and adult education can profoundly refine cortical organization.
0036-8075SCIEASScience : (Wash. D.C.)3306009How Learning to Read Changes the Cortical Networks for Vision and LanguageDEHAENE (Stanislas)PEGADO (Felipe)BRAGA (Lucia W.)VENTURA (Paulo)NUNES FILHO (Gilberto)JOBERT (Antoinette)DEHAENE-LAMBERTZ (Ghislaine)KOLINSKY (Régine)MORAIS (José)COHEN (Laurent)INSERM, Cognitive Neuroimaging UnitGif sur Yvette 91191FRA1 aut.2 aut.6 aut.7 aut.Commissariat à l'Energie Atomique, Direction des Sciences du Vivant, 12BM, Neurospin centerGif sur Yvette 91191FRA1 aut.2 aut.6 aut.7 aut.University Paris-Sud 1191405 OrsayFRA1 aut.2 aut.6 aut.7 aut.College de France, 11 Place Marcelin Berthelot75005 ParisFRA1 aut.SARAH Network-International Center for Neurosciences and Rehabilitation, QL 13, Lago Norte71.535-005 Brasilia, DFBRA3 aut.5 aut.Faculty of Psychology, University of Lisbon1600-214 LisbonPRT4 aut.Faculty of Psychology, Université Libre de Bruxelles (ULB)1050 BrusselsBEL8 aut.9 aut.Fonds de la Recherche Scientifique (FNRS)1000 BrusselsBEL8 aut.Université Pierre et Marie Curie-Paris 6, Faculté de Médecine Pitié-Salpêtrière75013 ParisFRA10 aut.Assistance Publique-Hôpitaux de Paris, Groupe hospitalier Pitié-Salpêtrière, Department of Neurology75651 ParisFRA10 aut.INSERM, Centre de Recherches de l'Institut du cerveau et de la moelle épinière, UMRS 975ParisFRA10 aut.1359-13642010ENGINIST60403540001949684401400000© 2011 INIST-CNRS. All rights reserved.11-0107175PAScience : (Washington, D.C.)USA1/4 p. ref. et notes dissem.Does literacy improve brain function? Does it also entail losses? Using functional magnetic resonance imaging, we measured brain responses to spoken and written language, visual faces, houses, tools, and checkers in adults of variable literacy (10 were illiterate, 22 became literate as adults, and 31 were literate in childhood). As literacy enhanced the left fusiform activation evoked by writing, it induced a small competition with faces at this location, but also broadly enhanced visual responses in fusiform and occipital cortex, extending to area V1. Literacy also enhanced phonological activation to speech in the planum temporale and afforded a top-down activation of orthography from spoken inputs. Most changes occurred even when literacy was acquired in adulthood, emphasizing that both childhood and adult education can profoundly refine cortical organization.002A26C04Imagerie fonctionnelle01Functional imaging01Imaginería funcional01Imagerie RMN02Nuclear magnetic resonance imaging02Imaginería RMN02Vision03Vision03Visión03Langage04Language04Lenguaje04Gyrus fusiforme05Fusiform gyrus05Gyrus fusiforme05Cortex occipital06Occipital cortex06Corteza occipital06Cortex visuel07Visual cortex07Corteza visual07Planum temporale08Planum temporale08Planum temporale08Alphabétisme09Literacy09Alfabetización09Parole10Speech10Habla10Ecriture11Hand writing11Escritura11Lecture12Reading12Lectura12Stimulus visuel13Visual stimulus13Estimulo visual13Face14Face14Cara14Outil15Tool15Herramienta15Phonologie16Phonology16Fonología16Orthographe17Orthography17Ortografía17Enfant18Child18Niño18Adulte19Adult19Adulto19HommeHumanHombrePerception37Perception37Percepción37Encéphale38Encephalon38Encéfalo38Système nerveux central39Central nervous system39Sistema nervioso central39Voie visuelle40Visual pathway40Vía visual40Cognition42Cognition42Cognición42066PASCAL 11-0107175 INISTHow Learning to Read Changes the Cortical Networks for Vision and LanguageDEHAENE (Stanislas); PEGADO (Felipe); BRAGA (Lucia W.); VENTURA (Paulo); NUNES FILHO (Gilberto); JOBERT (Antoinette); DEHAENE-LAMBERTZ (Ghislaine); KOLINSKY (Régine); MORAIS (José); COHEN (Laurent)INSERM, Cognitive Neuroimaging Unit/Gif sur Yvette 91191/France (1 aut., 2 aut., 6 aut., 7 aut.); Commissariat à l'Energie Atomique, Direction des Sciences du Vivant, 12BM, Neurospin center/Gif sur Yvette 91191/France (1 aut., 2 aut., 6 aut., 7 aut.); University Paris-Sud 11/91405 Orsay/France (1 aut., 2 aut., 6 aut., 7 aut.); College de France, 11 Place Marcelin Berthelot/75005 Paris/France (1 aut.); SARAH Network-International Center for Neurosciences and Rehabilitation, QL 13, Lago Norte/71.535-005 Brasilia, DF/Brésil (3 aut., 5 aut.); Faculty of Psychology, University of Lisbon/1600-214 Lisbon/Portugal (4 aut.); Faculty of Psychology, Université Libre de Bruxelles (ULB)/1050 Brussels/Belgique (8 aut., 9 aut.); Fonds de la Recherche Scientifique (FNRS)/1000 Brussels/Belgique (8 aut.); Université Pierre et Marie Curie-Paris 6, Faculté de Médecine Pitié-Salpêtrière/75013 Paris/France (10 aut.); Assistance Publique-Hôpitaux de Paris, Groupe hospitalier Pitié-Salpêtrière, Department of Neurology/75651 Paris/France (10 aut.); INSERM, Centre de Recherches de l'Institut du cerveau et de la moelle épinière, UMRS 975/Paris/France (10 aut.)
Publication en série; Niveau analytique
Science : (Washington, D.C.); ISSN 0036-8075; Coden SCIEAS; Etats-Unis; Da. 2010; Vol. 330; No. 6009; Pp. 1359-1364AnglaisDoes literacy improve brain function? Does it also entail losses? Using functional magnetic resonance imaging, we measured brain responses to spoken and written language, visual faces, houses, tools, and checkers in adults of variable literacy (10 were illiterate, 22 became literate as adults, and 31 were literate in childhood). As literacy enhanced the left fusiform activation evoked by writing, it induced a small competition with faces at this location, but also broadly enhanced visual responses in fusiform and occipital cortex, extending to area V1. Literacy also enhanced phonological activation to speech in the planum temporale and afforded a top-down activation of orthography from spoken inputs. Most changes occurred even when literacy was acquired in adulthood, emphasizing that both childhood and adult education can profoundly refine cortical organization.002A26C04Imagerie fonctionnelle; Imagerie RMN; Vision; Langage; Gyrus fusiforme; Cortex occipital; Cortex visuel; Planum temporale; Alphabétisme; Parole; Ecriture; Lecture; Stimulus visuel; Face; Outil; Phonologie; Orthographe; Enfant; AdulteHomme; Perception; Encéphale; Système nerveux central; Voie visuelle; CognitionFunctional imaging; Nuclear magnetic resonance imaging; Vision; Language; Fusiform gyrus; Occipital cortex; Visual cortex; Planum temporale; Literacy; Speech; Hand writing; Reading; Visual stimulus; Face; Tool; Phonology; Orthography; Child; AdultHuman; Perception; Encephalon; Central nervous system; Visual pathway; CognitionImaginería funcional; Imaginería RMN; Visión; Lenguaje; Gyrus fusiforme; Corteza occipital; Corteza visual; Planum temporale; Alfabetización; Habla; Escritura; Lectura; Estimulo visual; Cara; Herramienta; Fonología; Ortografía; Niño; AdultoINIST-6040.35400019496844014011-0107175 001625 Hybrid Bodyscapes: A Visual History of Yanesha Patterns of Cultural ChangeFernando Santos-GraneroSmithsonian Tropical Research Institute (Unit 9100, Box 0948DPO AA 34002-9998USA1 aut.Luisa Elvira Elvira BelaundeInstituto de Saúde Coletiva, MUSA-Programa de Estudos em Gênero e Saúde (Study Program in Gender and Health Studies), Rua Basilio da Gama, s/n Campus Universitário do CanelaSalvador-BA 40110040BRA2 aut.Sylvia Caiuby NovaesDepartamento de Antropologia da Faculdade de Filosofia, Letras e Ciências Humanas da Universidade de São Paulo, Avenida Prof. Luciano Gualberto 315, ButantaSão Paulo, SP 05508-010BRA3 aut.Jean-Pierre ChaumeilCentre Enseignement et Recherche en Ethnologie Amerindienne du Laboratoire d'Ethnologie et de Sociologie Comparative (UMR 7186), Centre National de la Recherche Scientifique-Université de Paris Ouest-Nanterre la Défense, 7 rue Guy Môquet BP894801 VillejuifFRA4 aut.Philippe EriksonMaison de l'Archéologie et de l'Ethnologie 21, allée de l'Université92023 NanterreFRA5 aut.Carlos FaustoMuseu Nacional, Departamento de Antropologia, Quinta da Boa Vista s/n, Rio de JaneiroRJ-Brasil 20940-040BRA6 aut.Dimitri KaradimasLaboratoire d'Anthropologie Sociale (Collège de France-Centre National Recherche Scientifique-EHESS), 52, rue du Cardinal-Lemoine75005 ParisFRA7 aut.Carlos David Londono SulkinDepartment of Anthropology, University of ReginaRegina, Saskatchewan S4S 0A2CAN8 aut.Donald PollockCollege Avenue, Niagara FallsNew York 14305USA9 aut.Steven RubensteinSchool of Languages, Cultures and Area Studies, ILAS Building, c/o Rendall Building, University of LiverpoolLiverpool L69 7WWGBR10 aut.Hanne VeberUniversity of Copenhagen, Department of Cross-Cultural and Regional Studies, American Indian Languages and Cultures Section, Artillerivej 86, St. 0.132300 Copenhagen SDNK11 aut.Harry WalkerDepartment of Anthropology, London School of Economics and Political Science, Houghton StreetLondon WC2A 2AEGBR12 aut.Neil L. WhiteheadDepartment of Anthropology, University of Wisconsin-Madison, 1180 Observatory DriveMadison, Wisconsin 53706USA13 aut.Robin M. WrightDepartment of Religion, 107C Anderson Hall, University of Florida-Gainesville, P.O. Box 117410Gainesville, Florida 32611-7410USA14 aut.11-01081052009FRANCIS 11-0108105 INISTFrancis:11-01081050014720011-3204Curr. anthropol.Current anthropologyAmazoniaBodyClothesCultural changeCultural practiceEmbodimentModificationOrnamentationPeruPostcolonial periodSouth AmericaTreatmentVisual anthropologyYaneshaChangement culturelAnthropologie visuelleModificationVêtementOrnementationTraitementCorpsYaneshaPérouAmérique du SudAmazoniePériode postcolonialeIncorporationPratique culturelleHybridationAutre
This paper examines cultural change and hybridity through a visual history of the alterations in dress, ornamentation, and body treatment experienced by the Yanesha of Peruvian Amazonia in postcolonial times. Such transformations often appear to be fluctuations between tradition and modernity explained alternatively as instances of "acculturation" or as expressions of "invented traditions" and "postmodern identity politics." By focusing mainly on external factors, these theoretical approaches pay insufficient attention to the role of native perceptions and practices in promoting cultural change. Approaches that do take into consideration these perceptions, such as those centered on the notions of "passing" and "mimesis," do not apply to this particular case. Adopting a Yanesha perspective as a departure point, I argue that what appear to be expressions of acculturative processes are the result of a long-standing indigenous openness to the Other-particularly the white and mestizo Others-and the native conviction that the Self is possible only through the incorporation of the Other. Such incorporation always finds expression in bodily transformations, hybrid bodyscapes that change throughout time according to the shifting relationships between Self and Other.
0011-3204Curr. anthropol.504Hybrid Bodyscapes: A Visual History of Yanesha Patterns of Cultural ChangeSANTOS-GRANERO (Fernando)ELVIRA BELAUNDE (Luisa Elvira)comment.CAIUBY NOVAES (Sylvia)comment.CHAUMEIL (Jean-Pierre)comment.ERIKSON (Philippe)comment.FAUSTO (Carlos)comment.KARADIMAS (Dimitri)comment.LONDONO SULKIN (Carlos David)comment.POLLOCK (Donald)comment.RUBENSTEIN (Steven)comment.VEBER (Hanne)comment.WALKER (Harry)comment.WHITEHEAD (Neil L.)comment.WRIGHT (Robin M.)comment.Smithsonian Tropical Research Institute (Unit 9100, Box 0948DPO AA 34002-9998USA1 aut.Instituto de Saúde Coletiva, MUSA-Programa de Estudos em Gênero e Saúde (Study Program in Gender and Health Studies), Rua Basilio da Gama, s/n Campus Universitário do CanelaSalvador-BA 40110040BRA2 aut.Departamento de Antropologia da Faculdade de Filosofia, Letras e Ciências Humanas da Universidade de São Paulo, Avenida Prof. Luciano Gualberto 315, ButantaSão Paulo, SP 05508-010BRA3 aut.Centre Enseignement et Recherche en Ethnologie Amerindienne du Laboratoire d'Ethnologie et de Sociologie Comparative (UMR 7186), Centre National de la Recherche Scientifique-Université de Paris Ouest-Nanterre la Défense, 7 rue Guy Môquet BP894801 VillejuifFRA4 aut.Maison de l'Archéologie et de l'Ethnologie 21, allée de l'Université92023 NanterreFRA5 aut.Museu Nacional, Departamento de Antropologia, Quinta da Boa Vista s/n, Rio de JaneiroRJ-Brasil 20940-040BRA6 aut.Laboratoire d'Anthropologie Sociale (Collège de France-Centre National Recherche Scientifique-EHESS), 52, rue du Cardinal-Lemoine75005 ParisFRA7 aut.Department of Anthropology, University of ReginaRegina, Saskatchewan S4S 0A2CAN8 aut.College Avenue, Niagara FallsNew York 14305USA9 aut.School of Languages, Cultures and Area Studies, ILAS Building, c/o Rendall Building, University of LiverpoolLiverpool L69 7WWGBR10 aut.University of Copenhagen, Department of Cross-Cultural and Regional Studies, American Indian Languages and Cultures Section, Artillerivej 86, St. 0.132300 Copenhagen SDNK11 aut.Department of Anthropology, London School of Economics and Political Science, Houghton StreetLondon WC2A 2AEGBR12 aut.Department of Anthropology, University of Wisconsin-Madison, 1180 Observatory DriveMadison, Wisconsin 53706USA13 aut.Department of Religion, 107C Anderson Hall, University of Florida-Gainesville, P.O. Box 117410Gainesville, Florida 32611-7410USA14 aut.477-5122009ENGINIST14573540001708203400300000© 2011 INIST-CNRS. All rights reserved.3 p.1/411-0108105PARCTACurrent anthropologyUSACorps hybrides : une histoire visuelle des modèles yaneshas du changement culturelThis paper examines cultural change and hybridity through a visual history of the alterations in dress, ornamentation, and body treatment experienced by the Yanesha of Peruvian Amazonia in postcolonial times. Such transformations often appear to be fluctuations between tradition and modernity explained alternatively as instances of "acculturation" or as expressions of "invented traditions" and "postmodern identity politics." By focusing mainly on external factors, these theoretical approaches pay insufficient attention to the role of native perceptions and practices in promoting cultural change. Approaches that do take into consideration these perceptions, such as those centered on the notions of "passing" and "mimesis," do not apply to this particular case. Adopting a Yanesha perspective as a departure point, I argue that what appear to be expressions of acculturative processes are the result of a long-standing indigenous openness to the Other-particularly the white and mestizo Others-and the native conviction that the Self is possible only through the incorporation of the Other. Such incorporation always finds expression in bodily transformations, hybrid bodyscapes that change throughout time according to the shifting relationships between Self and Other.52935III529Changement culturel01Cultural change01Anthropologie visuelle02Visual anthropology02Modification03Modification03Vêtement04Clothes04Ornementation05Ornamentation05Traitement06Treatment06Corps07Body07YaneshaNN08YaneshaNN08PérouNG09PeruNG09Amérique du SudNG10South AmericaNG10AmazonieNG11AmazoniaNG11Période postcolonialeND12Postcolonial periodND12Incorporation13Embodiment13Pratique culturelleNI14Cultural practiceNI14HybridationINC26AutreINC27073FRANCIS 11-0108105 INIST(Corps hybrides : une histoire visuelle des modèles yaneshas du changement culturel)Hybrid Bodyscapes: A Visual History of Yanesha Patterns of Cultural ChangeSANTOS-GRANERO (Fernando); ELVIRA BELAUNDE (Luisa Elvira); CAIUBY NOVAES (Sylvia); CHAUMEIL (Jean-Pierre); ERIKSON (Philippe); FAUSTO (Carlos); KARADIMAS (Dimitri); LONDONO SULKIN (Carlos David); POLLOCK (Donald); RUBENSTEIN (Steven); VEBER (Hanne); WALKER (Harry); WHITEHEAD (Neil L.); WRIGHT (Robin M.)Smithsonian Tropical Research Institute (Unit 9100, Box 0948/DPO AA 34002-9998/Etats-Unis (1 aut.); Instituto de Saúde Coletiva, MUSA-Programa de Estudos em Gênero e Saúde (Study Program in Gender and Health Studies), Rua Basilio da Gama, s/n Campus Universitário do Canela/Salvador-BA 40110040/Brésil (2 aut.); Departamento de Antropologia da Faculdade de Filosofia, Letras e Ciências Humanas da Universidade de São Paulo, Avenida Prof. Luciano Gualberto 315, Butanta/São Paulo, SP 05508-010/Brésil (3 aut.); Centre Enseignement et Recherche en Ethnologie Amerindienne du Laboratoire d'Ethnologie et de Sociologie Comparative (UMR 7186), Centre National de la Recherche Scientifique-Université de Paris Ouest-Nanterre la Défense, 7 rue Guy Môquet BP8/94801 Villejuif/France (4 aut.); Maison de l'Archéologie et de l'Ethnologie 21, allée de l'Université/92023 Nanterre/France (5 aut.); Museu Nacional, Departamento de Antropologia, Quinta da Boa Vista s/n, Rio de Janeiro/RJ-Brasil 20940-040/Brésil (6 aut.); Laboratoire d'Anthropologie Sociale (Collège de France-Centre National Recherche Scientifique-EHESS), 52, rue du Cardinal-Lemoine/75005 Paris/France (7 aut.); Department of Anthropology, University of Regina/Regina, Saskatchewan S4S 0A2/Canada (8 aut.); College Avenue, Niagara Falls/New York 14305/Etats-Unis (9 aut.); School of Languages, Cultures and Area Studies, ILAS Building, c/o Rendall Building, University of Liverpool/Liverpool L69 7WW/Royaume-Uni (10 aut.); University of Copenhagen, Department of Cross-Cultural and Regional Studies, American Indian Languages and Cultures Section, Artillerivej 86, St. 0.13/2300 Copenhagen S/Danemark (11 aut.); Department of Anthropology, London School of Economics and Political Science, Houghton Street/London WC2A 2AE/Royaume-Uni (12 aut.); Department of Anthropology, University of Wisconsin-Madison, 1180 Observatory Drive/Madison, Wisconsin 53706/Etats-Unis (13 aut.); Department of Religion, 107C Anderson Hall, University of Florida-Gainesville, P.O. Box 117410/Gainesville, Florida 32611-7410/Etats-Unis (14 aut.)
Publication en série; Article; Commentaire; Niveau analytique
Current anthropology; ISSN 0011-3204; Etats-Unis; Da. 2009; Vol. 50; No. 4; Pp. 477-512; Bibl. 3 p.1/4AnglaisThis paper examines cultural change and hybridity through a visual history of the alterations in dress, ornamentation, and body treatment experienced by the Yanesha of Peruvian Amazonia in postcolonial times. Such transformations often appear to be fluctuations between tradition and modernity explained alternatively as instances of "acculturation" or as expressions of "invented traditions" and "postmodern identity politics." By focusing mainly on external factors, these theoretical approaches pay insufficient attention to the role of native perceptions and practices in promoting cultural change. Approaches that do take into consideration these perceptions, such as those centered on the notions of "passing" and "mimesis," do not apply to this particular case. Adopting a Yanesha perspective as a departure point, I argue that what appear to be expressions of acculturative processes are the result of a long-standing indigenous openness to the Other-particularly the white and mestizo Others-and the native conviction that the Self is possible only through the incorporation of the Other. Such incorporation always finds expression in bodily transformations, hybrid bodyscapes that change throughout time according to the shifting relationships between Self and Other.52935; 529Changement culturel; Anthropologie visuelle; Modification; Vêtement; Ornementation; Traitement; Corps; Yanesha; Pérou; Amérique du Sud; Amazonie; Période postcoloniale; Incorporation; Pratique culturelle; Hybridation; AutreCultural change; Visual anthropology; Modification; Clothes; Ornamentation; Treatment; Body; Yanesha; Peru; South America; Amazonia; Postcolonial period; Embodiment; Cultural practiceINIST-1457.35400017082034003011-0108105 001626 A remarkable new genus and species of dragonfly (Odonata: Anisoptera: Libellulidae) from Brazil and notes on its bionomics and phylogenetic affinitiesG Nther FleckMuseu Integrado de Roraima, Av. Brigadeiro Eduardo Gomes, Parque Anauá69305-010 Boa Vista, RRBRA1 aut.CNRS UMR 5202, CP 50, Entomologie, Muséum National d'Histoire Naturelle, 45 Rue Buffon75005, ParisFRA1 aut.Eusa HamadaInstituto Nacional de Pesquisas da Amazônia (INPA), Coordenação de Pesquisas em Entomologia (CPEN), Avenida André Araújo, n. 2936, CP 4769011-970, Manaus, AMBRA2 aut.Alcimar L. CarvalhoDepartamento de Entomologia, Museu Nacional, Universidade Federal do Rio de Janeiro. CP 6804421944-970, Rio de Janeiro, RJBRA3 aut.11-01081832009PASCAL 11-0108183 INISTPascal:11-01081830012720037-9271Ann. Soc. entomol. Fr.Annales de la Société entomologique de FranceBrazilDiagnosis (taxonomy)LibellulidaeMorphologyNew genusNew speciesPhylogenyTaxonomySystématiqueDiagnoseMorphologieGenre nouveauEspèce nouvellePhylogenèseBrésilLibellulidaeOrionothemis felixorioni n. g. n. sp.
Orionothemis felixorioni n. gen., n. sp. de l'état de Bahia, Brésil, est décrit et illustré sur la base de la larve, d'adultes élevés et d'un adulte immature capturé en association avec sa possible exuvie larvaire. Ce taxon possède des caractères remarquables, comme des derniers segments abdominaux complètement fusionnés et d'énormes épines dorsale et latérales perpendiculaires à l'axe du corps chez la larve, des pattes postérieures fortement différenciées et avec un fort dimorphisme sexuel ainsi qu'un huitième tergite abdominal incomplètement chitinisé chez l'adulte. Orionothemis est très proche du genre néotropical Elasmothemis et du genre indo-malais Onychothemis. Ces larves ont été collectées dans l'abondante végétation immergée d'une petite rivière aux eaux fraiches et claires du 'planalto' brésilien (plateau central) dans une zone mise en danger par la déforestation et l'irrigation. Une meilleure connaissance des larves de Libellulidae et plus généralement des Odonata pourrait aider à résoudre la taxonomie et la phylogénie de ce groupe.
0037-9271ASEQAQAnn. Soc. entomol. Fr.453A remarkable new genus and species of dragonfly (Odonata: Anisoptera: Libellulidae) from Brazil and notes on its bionomics and phylogenetic affinitiesFLECK (Günther)HAMADA (Eusa)CARVALHO (Alcimar L.)Museu Integrado de Roraima, Av. Brigadeiro Eduardo Gomes, Parque Anauá69305-010 Boa Vista, RRBRA1 aut.CNRS UMR 5202, CP 50, Entomologie, Muséum National d'Histoire Naturelle, 45 Rue Buffon75005, ParisFRA1 aut.Instituto Nacional de Pesquisas da Amazônia (INPA), Coordenação de Pesquisas em Entomologia (CPEN), Avenida André Araújo, n. 2936, CP 4769011-970, Manaus, AMBRA2 aut.Departamento de Entomologia, Museu Nacional, Universidade Federal do Rio de Janeiro. CP 6804421944-970, Rio de Janeiro, RJBRA3 aut.275-2842009ENGfreINIST6187B3540001807320600200000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0108183PAAnnales de la Société entomologique de FranceFRAOrionothemis felixorioni n. gen., n. sp. de l'état de Bahia, Brésil, est décrit et illustré sur la base de la larve, d'adultes élevés et d'un adulte immature capturé en association avec sa possible exuvie larvaire. Ce taxon possède des caractères remarquables, comme des derniers segments abdominaux complètement fusionnés et d'énormes épines dorsale et latérales perpendiculaires à l'axe du corps chez la larve, des pattes postérieures fortement différenciées et avec un fort dimorphisme sexuel ainsi qu'un huitième tergite abdominal incomplètement chitinisé chez l'adulte. Orionothemis est très proche du genre néotropical Elasmothemis et du genre indo-malais Onychothemis. Ces larves ont été collectées dans l'abondante végétation immergée d'une petite rivière aux eaux fraiches et claires du 'planalto' brésilien (plateau central) dans une zone mise en danger par la déforestation et l'irrigation. Une meilleure connaissance des larves de Libellulidae et plus généralement des Odonata pourrait aider à résoudre la taxonomie et la phylogénie de ce groupe.002A12J01Systématique01Taxonomy01Sistemática01Diagnose02Diagnosis (taxonomy)02Diagnosis02Morphologie03Morphology03Morfología03Genre nouveau04New genus04Género nuevo04Espèce nouvelle05New species05Especie nueva05Phylogenèse06Phylogeny06Filogénesis06BrésilNG19BrazilNG19BrasilNG19LibellulidaeNS57LibellulidaeNS57LibellulidaeNS57Orionothemis felixorioni n. g. n. sp.INC87Amérique du SudNGSouth AmericaNGAmerica del surNGAmériqueNGAmericaNGAmericaNGOdonataNSOdonataNSOdonataNSInsectaNSInsectaNSInsectaNSArthropodaNSArthropodaNSArthropodaNSInvertebrataNSInvertebrataNSInvertebrataNS073PASCAL 11-0108183 INISTA remarkable new genus and species of dragonfly (Odonata: Anisoptera: Libellulidae) from Brazil and notes on its bionomics and phylogenetic affinitiesFLECK (Günther); HAMADA (Eusa); CARVALHO (Alcimar L.)Museu Integrado de Roraima, Av. Brigadeiro Eduardo Gomes, Parque Anauá/69305-010 Boa Vista, RR/Brésil (1 aut.); CNRS UMR 5202, CP 50, Entomologie, Muséum National d'Histoire Naturelle, 45 Rue Buffon/75005, Paris/France (1 aut.); Instituto Nacional de Pesquisas da Amazônia (INPA), Coordenação de Pesquisas em Entomologia (CPEN), Avenida André Araújo, n. 2936, CP 47/69011-970, Manaus, AM/Brésil (2 aut.); Departamento de Entomologia, Museu Nacional, Universidade Federal do Rio de Janeiro. CP 68044/21944-970, Rio de Janeiro, RJ/Brésil (3 aut.)
Publication en série; Niveau analytique
Annales de la Société entomologique de France; ISSN 0037-9271; Coden ASEQAQ; France; Da. 2009; Vol. 45; No. 3; Pp. 275-284; Abs. français; Bibl. 3/4 p.AnglaisOrionothemis felixorioni n. gen., n. sp. de l'état de Bahia, Brésil, est décrit et illustré sur la base de la larve, d'adultes élevés et d'un adulte immature capturé en association avec sa possible exuvie larvaire. Ce taxon possède des caractères remarquables, comme des derniers segments abdominaux complètement fusionnés et d'énormes épines dorsale et latérales perpendiculaires à l'axe du corps chez la larve, des pattes postérieures fortement différenciées et avec un fort dimorphisme sexuel ainsi qu'un huitième tergite abdominal incomplètement chitinisé chez l'adulte. Orionothemis est très proche du genre néotropical Elasmothemis et du genre indo-malais Onychothemis. Ces larves ont été collectées dans l'abondante végétation immergée d'une petite rivière aux eaux fraiches et claires du 'planalto' brésilien (plateau central) dans une zone mise en danger par la déforestation et l'irrigation. Une meilleure connaissance des larves de Libellulidae et plus généralement des Odonata pourrait aider à résoudre la taxonomie et la phylogénie de ce groupe.002A12J01Systématique; Diagnose; Morphologie; Genre nouveau; Espèce nouvelle; Phylogenèse; Brésil; Libellulidae; Orionothemis felixorioni n. g. n. sp.Amérique du Sud; Amérique; Odonata; Insecta; Arthropoda; InvertebrataTaxonomy; Diagnosis (taxonomy); Morphology; New genus; New species; Phylogeny; Brazil; LibellulidaeSouth America; America; Odonata; Insecta; Arthropoda; InvertebrataSistemática; Diagnosis; Morfología; Género nuevo; Especie nueva; Filogénesis; Brasil; LibellulidaeINIST-6187B.35400018073206002011-0108183 001627 Primary Production in a Subtropical Stratified Coastal Lagoon-Contribution of Anoxygenic Phototrophic BacteriaMaria Luiza S. FontesInstitute of Oceanography, Federal University of Rio Grande, Av. Itália km 8, Campus CarreirosRio Grande, Rio Grande do SulBRA1 aut.4 aut.Marcelino T. SuzukiChesapeake Biological Laboratory, University of Maryland Center for Environmental Science, One Williams St, P.O. Box 38Solomons, MD 20688USA2 aut.CNRS, UMR 7621, LOMIC, Observatoire Océanologique66651 Banyuls/merFRA2 aut.Matthew T. CottrellCollege of Earth, Ocean, and Environment, University of Delaware, 700 Pilottown RdLewes, DE 19958USA3 aut.Paulo C. AbreuInstitute of Oceanography, Federal University of Rio Grande, Av. Itália km 8, Campus CarreirosRio Grande, Rio Grande do SulBRA1 aut.4 aut.11-01085252011PASCAL 11-0108525 INISTPascal:11-01085250012710095-3628Microb. ecol.Microbial ecologyBacteriaBrackish water environmentCoastal lagoonEcologyPhototrophyPrimary productivityBactérieProductivité primaireLagunePhototrophieEcologieMilieu saumâtre
Anaerobic anoxygenic phototrophic bacteria can be found in the suboxic waters of shallow stratified coastal systems, and may play important roles in the total primary production of subtropical stratified coastal lagoons. We investigated the spatiotemporal variability of light CO2 fixation and net oxygen production in the stratified Conceição Lagoon (Brazil) in summer and fall of 2007, as well as the contribution of bacteriochlorophyll a (BChl a)-containing bacteria to photosynthetically driven electron transfer. Both chlorophyll a (Chl a) and BChl a varied in space, while only BChl a varied in time (three-fold increase from summer to fall). In summer, net oxygen production and light CO2 fixation were correlated, with both having higher rates with higher Chl a concentrations in the enclosed region of the lagoon. In fall, CO2 fixation was decoupled from oxygen production. Denaturing gradient gel electrophoresis revealed that bacterial communities of oxic site 12 and suboxic site 33 formed one cluster, different from other oxic samples within the lagoon. In addition, BChl a/Chl a ratios at these sites were high, 40% and 45%, respectively. Light acted as the main factor controlling the BChl a concentration and CO2 fixation rates. High turbidity within the enclosed area of the lagoon explained high BChl a and decoupling between CO2 fixation and oxygen production in oxygenated waters. Contribution of purple sulfur bacteria to total bacterial density in suboxic waters was 1.2%, and their biomass contributed to a much higher percentage (12.2%) due to their large biovolume. Our results indicate a significant contribution of anaerobic anoxygenic bacteria to the primary production of the "dead zone" of Conceição Lagoon.
0095-3628MCBEBUMicrob. ecol.611Primary Production in a Subtropical Stratified Coastal Lagoon-Contribution of Anoxygenic Phototrophic BacteriaFONTES (Maria Luiza S.)SUZUKI (Marcelino T.)COTTRELL (Matthew T.)ABREU (Paulo C.)Institute of Oceanography, Federal University of Rio Grande, Av. Itália km 8, Campus CarreirosRio Grande, Rio Grande do SulBRA1 aut.4 aut.Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, One Williams St, P.O. Box 38Solomons, MD 20688USA2 aut.College of Earth, Ocean, and Environment, University of Delaware, 700 Pilottown RdLewes, DE 19958USA3 aut.CNRS, UMR 7621, LOMIC, Observatoire Océanologique66651 Banyuls/merFRA2 aut.223-2372011ENGINIST162633540001936143602200000© 2011 INIST-CNRS. All rights reserved.63 ref.11-0108525PAMicrobial ecologyDEUAnaerobic anoxygenic phototrophic bacteria can be found in the suboxic waters of shallow stratified coastal systems, and may play important roles in the total primary production of subtropical stratified coastal lagoons. We investigated the spatiotemporal variability of light CO2 fixation and net oxygen production in the stratified Conceição Lagoon (Brazil) in summer and fall of 2007, as well as the contribution of bacteriochlorophyll a (BChl a)-containing bacteria to photosynthetically driven electron transfer. Both chlorophyll a (Chl a) and BChl a varied in space, while only BChl a varied in time (three-fold increase from summer to fall). In summer, net oxygen production and light CO2 fixation were correlated, with both having higher rates with higher Chl a concentrations in the enclosed region of the lagoon. In fall, CO2 fixation was decoupled from oxygen production. Denaturing gradient gel electrophoresis revealed that bacterial communities of oxic site 12 and suboxic site 33 formed one cluster, different from other oxic samples within the lagoon. In addition, BChl a/Chl a ratios at these sites were high, 40% and 45%, respectively. Light acted as the main factor controlling the BChl a concentration and CO2 fixation rates. High turbidity within the enclosed area of the lagoon explained high BChl a and decoupling between CO2 fixation and oxygen production in oxygenated waters. Contribution of purple sulfur bacteria to total bacterial density in suboxic waters was 1.2%, and their biomass contributed to a much higher percentage (12.2%) due to their large biovolume. Our results indicate a significant contribution of anaerobic anoxygenic bacteria to the primary production of the "dead zone" of Conceição Lagoon.002A05Bactérie01Bacteria01Bacteria01Productivité primaire05Primary productivity05Productividad primaria05Lagune06Coastal lagoon06Laguna06Phototrophie07Phototrophy07Fototrofia07Ecologie08Ecology08Ecología08Milieu saumâtre45Brackish water environment45Medio salobre45Milieu aquatique13Aquatic environment13Medio acuático13073OTOOTOPASCAL 11-0108525 INISTPrimary Production in a Subtropical Stratified Coastal Lagoon-Contribution of Anoxygenic Phototrophic BacteriaFONTES (Maria Luiza S.); SUZUKI (Marcelino T.); COTTRELL (Matthew T.); ABREU (Paulo C.)Institute of Oceanography, Federal University of Rio Grande, Av. Itália km 8, Campus Carreiros/Rio Grande, Rio Grande do Sul/Brésil (1 aut., 4 aut.); Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, One Williams St, P.O. Box 38/Solomons, MD 20688/Etats-Unis (2 aut.); College of Earth, Ocean, and Environment, University of Delaware, 700 Pilottown Rd/Lewes, DE 19958/Etats-Unis (3 aut.); CNRS, UMR 7621, LOMIC, Observatoire Océanologique/66651 Banyuls/mer/France (2 aut.)
Publication en série; Niveau analytique
Microbial ecology; ISSN 0095-3628; Coden MCBEBU; Allemagne; Da. 2011; Vol. 61; No. 1; Pp. 223-237; Bibl. 63 ref.AnglaisAnaerobic anoxygenic phototrophic bacteria can be found in the suboxic waters of shallow stratified coastal systems, and may play important roles in the total primary production of subtropical stratified coastal lagoons. We investigated the spatiotemporal variability of light CO2 fixation and net oxygen production in the stratified Conceição Lagoon (Brazil) in summer and fall of 2007, as well as the contribution of bacteriochlorophyll a (BChl a)-containing bacteria to photosynthetically driven electron transfer. Both chlorophyll a (Chl a) and BChl a varied in space, while only BChl a varied in time (three-fold increase from summer to fall). In summer, net oxygen production and light CO2 fixation were correlated, with both having higher rates with higher Chl a concentrations in the enclosed region of the lagoon. In fall, CO2 fixation was decoupled from oxygen production. Denaturing gradient gel electrophoresis revealed that bacterial communities of oxic site 12 and suboxic site 33 formed one cluster, different from other oxic samples within the lagoon. In addition, BChl a/Chl a ratios at these sites were high, 40% and 45%, respectively. Light acted as the main factor controlling the BChl a concentration and CO2 fixation rates. High turbidity within the enclosed area of the lagoon explained high BChl a and decoupling between CO2 fixation and oxygen production in oxygenated waters. Contribution of purple sulfur bacteria to total bacterial density in suboxic waters was 1.2%, and their biomass contributed to a much higher percentage (12.2%) due to their large biovolume. Our results indicate a significant contribution of anaerobic anoxygenic bacteria to the primary production of the "dead zone" of Conceição Lagoon.002A05Bactérie; Productivité primaire; Lagune; Phototrophie; Ecologie; Milieu saumâtreMilieu aquatiqueBacteria; Primary productivity; Coastal lagoon; Phototrophy; Ecology; Brackish water environmentAquatic environmentBacteria; Productividad primaria; Laguna; Fototrofia; Ecología; Medio salobreINIST-16263.35400019361436022011-0108525 001628 Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in miceJean Guy LeblancCentro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, San Miguel de TucumánTucumán T4000ILCARG1 aut.2 aut.5 aut.9 aut.10 aut.Silvina Del CarmenCentro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, San Miguel de TucumánTucumán T4000ILCARG1 aut.2 aut.5 aut.9 aut.10 aut.Anderson MiyoshiInstituto de Microbiología, Universidade Federal de Minas Gerais (ICB/UFMG)Belo HorizonteBRA3 aut.4 aut.Vasco AzevedoInstituto de Microbiología, Universidade Federal de Minas Gerais (ICB/UFMG)Belo HorizonteBRA3 aut.4 aut.Fernando SesmaCentro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, San Miguel de TucumánTucumán T4000ILCARG1 aut.2 aut.5 aut.9 aut.10 aut.Philippe LangellaUMR 1319 MICALIS-Microbiologie de l'Alimentation au Service de la Santé humaine, INRA-Institut National de la Recherche Agronomique. Domaine de Vilvert78352 Jouy-en-JosasFRA6 aut.7 aut.8 aut.Luis G. Bermudez-HumaranUMR 1319 MICALIS-Microbiologie de l'Alimentation au Service de la Santé humaine, INRA-Institut National de la Recherche Agronomique. Domaine de Vilvert78352 Jouy-en-JosasFRA6 aut.7 aut.8 aut.Laurie WatterlotUMR 1319 MICALIS-Microbiologie de l'Alimentation au Service de la Santé humaine, INRA-Institut National de la Recherche Agronomique. Domaine de Vilvert78352 Jouy-en-JosasFRA6 aut.7 aut.8 aut.Gabriela PerdigonCentro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, San Miguel de TucumánTucumán T4000ILCARG1 aut.2 aut.5 aut.9 aut.10 aut.Cátedra de Inmunología, Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de TucumánARG9 aut.Alejandra De Moreno De LeblancCentro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, San Miguel de TucumánTucumán T4000ILCARG1 aut.2 aut.5 aut.9 aut.10 aut.11-01087072011PASCAL 11-0108707 INISTPascal:11-01087070012700168-1656J. biotechnol.Journal of biotechnologyCatalaseCrohn diseaseGutInflammationLactic acid bacteriaMouseSuperoxide dismutaseSuperoxide dismutaseCatalaseBactérie lactiqueEntérite de CrohnSourisIntestinInflammation
Reactive oxygen species are involved in various aspects of intestinal inflammation and tumor development. Decreasing their levels using antioxidant enzymes, such as catalase (CAT) or superoxide dismutase (SOD) could therefore be useful in the prevention of certain diseases. Lactic acid bacteria (LAB) are ideal candidates to deliver these enzymes in the gut. In this study, the anti-inflammatory effects of CAT or SOD producing LAB were evaluated using a trinitrobenzenesulfonic acid (TNBS) induced Crohn's disease murine model. Engineered Lactobacillus casei BL23 strains producing either CAT or SOD, or the native strain were given to mice before and after intrarectal administration of TNBS. Animal survival, live weight, intestinal morphology and histology, enzymatic activities, microbial translocation to the liver and cytokines released in the intestinal fluid were evaluated. The mice that received CAT or SOD-producing LAB showed a faster recovery of initial weight loss, increased enzymatic activities in the gut and lesser extent of intestinal inflammation compared to animals that received the wild-type strain or those that did not receive bacterial supplementation. Our findings suggest that genetically engineered LAB that produce antioxidant enzymes could be used to prevent or decrease the severity of certain intestinal pathologies.
0168-1656JBITD4J. biotechnol.1513Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in miceLEBLANC (Jean Guy)DEL CARMEN (Silvina)MIYOSHI (Anderson)AZEVEDO (Vasco)SESMA (Fernando)LANGELLA (Philippe)BERMUDEZ-HUMARAN (Luis G.)WATTERLOT (Laurie)PERDIGON (Gabriela)DE MORENO DE LEBLANC (Alejandra)Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, San Miguel de TucumánTucumán T4000ILCARG1 aut.2 aut.5 aut.9 aut.10 aut.Instituto de Microbiología, Universidade Federal de Minas Gerais (ICB/UFMG)Belo HorizonteBRA3 aut.4 aut.UMR 1319 MICALIS-Microbiologie de l'Alimentation au Service de la Santé humaine, INRA-Institut National de la Recherche Agronomique. Domaine de Vilvert78352 Jouy-en-JosasFRA6 aut.7 aut.8 aut.Cátedra de Inmunología, Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de TucumánARG9 aut.287-2932011ENGINIST203053540001936183200800000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0108707PAJournal of biotechnologyNLDReactive oxygen species are involved in various aspects of intestinal inflammation and tumor development. Decreasing their levels using antioxidant enzymes, such as catalase (CAT) or superoxide dismutase (SOD) could therefore be useful in the prevention of certain diseases. Lactic acid bacteria (LAB) are ideal candidates to deliver these enzymes in the gut. In this study, the anti-inflammatory effects of CAT or SOD producing LAB were evaluated using a trinitrobenzenesulfonic acid (TNBS) induced Crohn's disease murine model. Engineered Lactobacillus casei BL23 strains producing either CAT or SOD, or the native strain were given to mice before and after intrarectal administration of TNBS. Animal survival, live weight, intestinal morphology and histology, enzymatic activities, microbial translocation to the liver and cytokines released in the intestinal fluid were evaluated. The mice that received CAT or SOD-producing LAB showed a faster recovery of initial weight loss, increased enzymatic activities in the gut and lesser extent of intestinal inflammation compared to animals that received the wild-type strain or those that did not receive bacterial supplementation. Our findings suggest that genetically engineered LAB that produce antioxidant enzymes could be used to prevent or decrease the severity of certain intestinal pathologies.002A31215Superoxide dismutaseFE01Superoxide dismutaseFE01Superoxide dismutaseFE01CatalaseFE02CatalaseFE02CatalaseFE02Bactérie lactique10Lactic acid bacteria10Bacteria láctica10Entérite de Crohn11Crohn disease11Enteritis Crohn11Souris12Mouse12Ratón12Intestin19Gut19Intestino19Inflammation20Inflammation20Inflamación20OxidoreductasesFEOxidoreductasesFEOxidoreductasesFEEnzymeFEEnzymeFEEnzimaFEPeroxidasesFEPeroxidasesFEPeroxidasesFERodentiaNSRodentiaNSRodentiaNSMammaliaNSMammaliaNSMammaliaNSVertebrataNSVertebrataNSVertebrataNS073OTOOTOPASCAL 11-0108707 INISTUse of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in miceLEBLANC (Jean Guy); DEL CARMEN (Silvina); MIYOSHI (Anderson); AZEVEDO (Vasco); SESMA (Fernando); LANGELLA (Philippe); BERMUDEZ-HUMARAN (Luis G.); WATTERLOT (Laurie); PERDIGON (Gabriela); DE MORENO DE LEBLANC (Alejandra)Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, San Miguel de Tucumán/Tucumán T4000ILC/Argentine (1 aut., 2 aut., 5 aut., 9 aut., 10 aut.); Instituto de Microbiología, Universidade Federal de Minas Gerais (ICB/UFMG)/Belo Horizonte/Brésil (3 aut., 4 aut.); UMR 1319 MICALIS-Microbiologie de l'Alimentation au Service de la Santé humaine, INRA-Institut National de la Recherche Agronomique. Domaine de Vilvert/78352 Jouy-en-Josas/France (6 aut., 7 aut., 8 aut.); Cátedra de Inmunología, Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán/Argentine (9 aut.)
Publication en série; Niveau analytique
Journal of biotechnology; ISSN 0168-1656; Coden JBITD4; Pays-Bas; Da. 2011; Vol. 151; No. 3; Pp. 287-293; Bibl. 3/4 p.AnglaisReactive oxygen species are involved in various aspects of intestinal inflammation and tumor development. Decreasing their levels using antioxidant enzymes, such as catalase (CAT) or superoxide dismutase (SOD) could therefore be useful in the prevention of certain diseases. Lactic acid bacteria (LAB) are ideal candidates to deliver these enzymes in the gut. In this study, the anti-inflammatory effects of CAT or SOD producing LAB were evaluated using a trinitrobenzenesulfonic acid (TNBS) induced Crohn's disease murine model. Engineered Lactobacillus casei BL23 strains producing either CAT or SOD, or the native strain were given to mice before and after intrarectal administration of TNBS. Animal survival, live weight, intestinal morphology and histology, enzymatic activities, microbial translocation to the liver and cytokines released in the intestinal fluid were evaluated. The mice that received CAT or SOD-producing LAB showed a faster recovery of initial weight loss, increased enzymatic activities in the gut and lesser extent of intestinal inflammation compared to animals that received the wild-type strain or those that did not receive bacterial supplementation. Our findings suggest that genetically engineered LAB that produce antioxidant enzymes could be used to prevent or decrease the severity of certain intestinal pathologies.002A31; 215Superoxide dismutase; Catalase; Bactérie lactique; Entérite de Crohn; Souris; Intestin; InflammationOxidoreductases; Enzyme; Peroxidases; Rodentia; Mammalia; VertebrataSuperoxide dismutase; Catalase; Lactic acid bacteria; Crohn disease; Mouse; Gut; InflammationOxidoreductases; Enzyme; Peroxidases; Rodentia; Mammalia; VertebrataSuperoxide dismutase; Catalase; Bacteria láctica; Enteritis Crohn; Ratón; Intestino; InflamaciónINIST-20305.35400019361832008011-0108707 001629 Person-centred Integrative Diagnosis: Conceptual Bases and Structural Model : New developments on classification and diagnostic systemsJuan E. MezzichInternational Network for Person-centered MedicineNew York, New YorkUSA1 aut.Ihsan M. SalloumUniversity of Miami Miller School of MedicineMiami, FloridaUSA2 aut.C. Robert CloningerCenter for Wellbeing, Washington University School of MedicineSt Louis, MissouriUSA3 aut.Luis Salvador-CarullaUniversity of CadizCadizESP4 aut.Laurence J. KirmayerDivision of Social and Transcultural Psychiatry, McGill UniversityMontreal, QuebecCAN5 aut.Claudio Em BanzatoUniversity of CampinasCampinasBRA6 aut.Jan WallcraftCentre for Mental Health Recovery, University of Hertfordshire, Hatfield, England; Honorary Fellow, University of BirminghamBirminghamGBR7 aut.Michel BotbolJustice to the Ministry of JusticeParisFRA8 aut.11-01087502010PASCAL 11-0108750 INISTPascal:11-0108750001269FRANCIS 11-0108750 INIST0706-7437Can. j. psychiatryCanadian journal of psychiatryCanadaClassificationCriterionDiagnosisHumanMental healthNosologyPartnershipPerson-centered approachResearch programReviewService integrationSocial environmentStructural theoryTheoretical modelDiagnosticCritèreNosologieClassificationPartenariatModèle théoriqueThéorie structurelleIntégration serviceProgramme rechercheArticle synthèseSanté mentaleEnvironnement socialCanadaHommePrise de décision partagéeApproche centrée sur la personne
Objectifs: Examiner les bases conceptuelles du diagnostic intégrant centré sur la personne (DIP) à titre de composant et participant de la psychiatrie et de la médecine centrées sur la personne, et en présenter la conception et le développement. Méthode: Une analyse des racines historiques de la psychiatrie et de la médecine centrées sur la personne a été menée. Ces racines remontent aux anciennes civilisations orientales et occidentales, aux vicissitudes de la médecine moderne, aux récents développements cliniques et conceptuels, et aux nouvelles initiatives voulant changer la priorité de la médecine de la maladie au patient à la personne, en collaboration avec l'Association médicale mondiale, l'Organisation mondiale de la santé, l'Organisation mondiale des médecins généralistes, la Fédération mondiale pour la santé mentale et de nombreux autres organismes mondiaux de la santé, et avec l'aide à la coordination du Réseau international pour la médecine centrée sur la personne. Résultats: L'une des principales réussites au sein du vaste développement de la santé paradigmatique présenté ci-dessus est la conception du DIP. Ce modèle diagnostique allie science et humanisme pour obtenir un diagnostic de la personne (de la totalité de la santé de la personne, tant les aspects malades que positifs), par la personne (les cliniciens se présentant comme de véritables êtres humains), pour la personne (aidant à réaliser les aspirations de santé de la personne et son projet de vie), et avec la personne (dans une relation respectueuse et habilitante avec la personne qui consulte). Cette notion plus large et plus profonde du diagnostic va plus loin que les concepts plus restreints des diagnostics nosologique et différentiel. Le modèle DIP proposé est défini par trois clés: de vastes domaines d'information, couvrant la santé malade et la santé positive sur trois niveaux: l'état de santé, l'expérience de santé, et les contributeurs à la santé; les procédures descriptives pluralistes (catégories, dimensions et narratives); et des partenariats d'évaluation parmi les cliniciens, les patients, et les familles. Un programme de recherche en cours porte sur la construction d'un guide pratique et de son évaluation, suivi d'initiatives pour faciliter la mise en œuvre clinique et la formation. Conclusions: Le DIP vise à évaluer la santé générale par des descriptions pluralistes et des partenariats d'évaluation, et mène un programme de recherche pour des soins de santé plus efficaces, intégrants et centrés sur la personne.
0706-7437CJPSDFCan. j. psychiatry5511Person-centred Integrative Diagnosis: Conceptual Bases and Structural Model : New developments on classification and diagnostic systemsMEZZICH (Juan E.)SALLOUM (Ihsan M.)CLONINGER (C. Robert)SALVADOR-CARULLA (Luis)KIRMAYER (Laurence J.)BANZATO (Claudio Em)WALLCRAFT (Jan)BOTBOL (Michel)International Network for Person-centered MedicineNew York, New YorkUSA1 aut.University of Miami Miller School of MedicineMiami, FloridaUSA2 aut.Center for Wellbeing, Washington University School of MedicineSt Louis, MissouriUSA3 aut.University of CadizCadizESP4 aut.Division of Social and Transcultural Psychiatry, McGill UniversityMontreal, QuebecCAN5 aut.University of CampinasCampinasBRA6 aut.Centre for Mental Health Recovery, University of Hertfordshire, Hatfield, England; Honorary Fellow, University of BirminghamBirminghamGBR7 aut.Justice to the Ministry of JusticeParisFRA8 aut.701-7082010ENGfreINIST135913540001939971700200000© 2011 INIST-CNRS. All rights reserved.89 ref.11-0108750PACanadian journal of psychiatryCANObjectifs: Examiner les bases conceptuelles du diagnostic intégrant centré sur la personne (DIP) à titre de composant et participant de la psychiatrie et de la médecine centrées sur la personne, et en présenter la conception et le développement. Méthode: Une analyse des racines historiques de la psychiatrie et de la médecine centrées sur la personne a été menée. Ces racines remontent aux anciennes civilisations orientales et occidentales, aux vicissitudes de la médecine moderne, aux récents développements cliniques et conceptuels, et aux nouvelles initiatives voulant changer la priorité de la médecine de la maladie au patient à la personne, en collaboration avec l'Association médicale mondiale, l'Organisation mondiale de la santé, l'Organisation mondiale des médecins généralistes, la Fédération mondiale pour la santé mentale et de nombreux autres organismes mondiaux de la santé, et avec l'aide à la coordination du Réseau international pour la médecine centrée sur la personne. Résultats: L'une des principales réussites au sein du vaste développement de la santé paradigmatique présenté ci-dessus est la conception du DIP. Ce modèle diagnostique allie science et humanisme pour obtenir un diagnostic de la personne (de la totalité de la santé de la personne, tant les aspects malades que positifs), par la personne (les cliniciens se présentant comme de véritables êtres humains), pour la personne (aidant à réaliser les aspirations de santé de la personne et son projet de vie), et avec la personne (dans une relation respectueuse et habilitante avec la personne qui consulte). Cette notion plus large et plus profonde du diagnostic va plus loin que les concepts plus restreints des diagnostics nosologique et différentiel. Le modèle DIP proposé est défini par trois clés: de vastes domaines d'information, couvrant la santé malade et la santé positive sur trois niveaux: l'état de santé, l'expérience de santé, et les contributeurs à la santé; les procédures descriptives pluralistes (catégories, dimensions et narratives); et des partenariats d'évaluation parmi les cliniciens, les patients, et les familles. Un programme de recherche en cours porte sur la construction d'un guide pratique et de son évaluation, suivi d'initiatives pour faciliter la mise en œuvre clinique et la formation. Conclusions: Le DIP vise à évaluer la santé générale par des descriptions pluralistes et des partenariats d'évaluation, et mène un programme de recherche pour des soins de santé plus efficaces, intégrants et centrés sur la personne.002B18B02Diagnostic01Diagnosis01Diagnóstico01Critère02Criterion02Criterio02Nosologie03Nosology03Nosología03Classification04Classification04Clasificación04Partenariat05Partnership05Coparticipación05Modèle théorique06Theoretical model06Modelo teórico06Théorie structurelle07Structural theory07Teoría estructural07Intégration service08Service integration08Integración servicio08Programme recherche09Research program09Programa investigación09Article synthèse10Review10Artículo síntesis10Santé mentale11Mental health11Salud mental11Environnement social12Social environment12Contexto social12CanadaNG13CanadaNG13CanadáNG13Homme18Human18Hombre18Prise de décision partagéeINC86Approche centrée sur la personneCD96Person-centered approachCD96Enfoque centrado en la personaCD96Amérique du NordNGNorth AmericaNGAmerica del norteNGAmériqueNGAmericaNGAmericaNGSanté publique37Public health37Salud pública37073PASCAL 11-0108750 INISTPerson-centred Integrative Diagnosis: Conceptual Bases and Structural Model : New developments on classification and diagnostic systemsMEZZICH (Juan E.); SALLOUM (Ihsan M.); CLONINGER (C. Robert); SALVADOR-CARULLA (Luis); KIRMAYER (Laurence J.); BANZATO (Claudio Em); WALLCRAFT (Jan); BOTBOL (Michel)International Network for Person-centered Medicine/New York, New York/Etats-Unis (1 aut.); University of Miami Miller School of Medicine/Miami, Florida/Etats-Unis (2 aut.); Center for Wellbeing, Washington University School of Medicine/St Louis, Missouri/Etats-Unis (3 aut.); University of Cadiz/Cadiz/Espagne (4 aut.); Division of Social and Transcultural Psychiatry, McGill University/Montreal, Quebec/Canada (5 aut.); University of Campinas/Campinas/Brésil (6 aut.); Centre for Mental Health Recovery, University of Hertfordshire, Hatfield, England; Honorary Fellow, University of Birmingham/Birmingham/Royaume-Uni (7 aut.); Justice to the Ministry of Justice/Paris/France (8 aut.)
Publication en série; Niveau analytique
Canadian journal of psychiatry; ISSN 0706-7437; Coden CJPSDF; Canada; Da. 2010; Vol. 55; No. 11; Pp. 701-708; Abs. français; Bibl. 89 ref.AnglaisObjectifs: Examiner les bases conceptuelles du diagnostic intégrant centré sur la personne (DIP) à titre de composant et participant de la psychiatrie et de la médecine centrées sur la personne, et en présenter la conception et le développement. Méthode: Une analyse des racines historiques de la psychiatrie et de la médecine centrées sur la personne a été menée. Ces racines remontent aux anciennes civilisations orientales et occidentales, aux vicissitudes de la médecine moderne, aux récents développements cliniques et conceptuels, et aux nouvelles initiatives voulant changer la priorité de la médecine de la maladie au patient à la personne, en collaboration avec l'Association médicale mondiale, l'Organisation mondiale de la santé, l'Organisation mondiale des médecins généralistes, la Fédération mondiale pour la santé mentale et de nombreux autres organismes mondiaux de la santé, et avec l'aide à la coordination du Réseau international pour la médecine centrée sur la personne. Résultats: L'une des principales réussites au sein du vaste développement de la santé paradigmatique présenté ci-dessus est la conception du DIP. Ce modèle diagnostique allie science et humanisme pour obtenir un diagnostic de la personne (de la totalité de la santé de la personne, tant les aspects malades que positifs), par la personne (les cliniciens se présentant comme de véritables êtres humains), pour la personne (aidant à réaliser les aspirations de santé de la personne et son projet de vie), et avec la personne (dans une relation respectueuse et habilitante avec la personne qui consulte). Cette notion plus large et plus profonde du diagnostic va plus loin que les concepts plus restreints des diagnostics nosologique et différentiel. Le modèle DIP proposé est défini par trois clés: de vastes domaines d'information, couvrant la santé malade et la santé positive sur trois niveaux: l'état de santé, l'expérience de santé, et les contributeurs à la santé; les procédures descriptives pluralistes (catégories, dimensions et narratives); et des partenariats d'évaluation parmi les cliniciens, les patients, et les familles. Un programme de recherche en cours porte sur la construction d'un guide pratique et de son évaluation, suivi d'initiatives pour faciliter la mise en œuvre clinique et la formation. Conclusions: Le DIP vise à évaluer la santé générale par des descriptions pluralistes et des partenariats d'évaluation, et mène un programme de recherche pour des soins de santé plus efficaces, intégrants et centrés sur la personne.002B18B02Diagnostic; Critère; Nosologie; Classification; Partenariat; Modèle théorique; Théorie structurelle; Intégration service; Programme recherche; Article synthèse; Santé mentale; Environnement social; Canada; Homme; Prise de décision partagée; Approche centrée sur la personneAmérique du Nord; Amérique; Santé publiqueDiagnosis; Criterion; Nosology; Classification; Partnership; Theoretical model; Structural theory; Service integration; Research program; Review; Mental health; Social environment; Canada; Human; Person-centered approachNorth America; America; Public healthDiagnóstico; Criterio; Nosología; Clasificación; Coparticipación; Modelo teórico; Teoría estructural; Integración servicio; Programa investigación; Artículo síntesis; Salud mental; Contexto social; Canadá; Hombre; Enfoque centrado en la personaINIST-13591.35400019399717002011-0108750 001630 Minimizing orbits in the discrete Aubry-Mather modelEduardo GaribaldiDepartamento de Matemática, Universidade Estadual de Campinas13083-859 Campinas - SPBRA1 aut.Philippe ThieullenInstitut de Mathématiques, Université Bordeaux 1, CNRS, UMR 525133405 TalenceFRA2 aut.11-01093442011PASCAL 11-0109344 INISTPascal:11-01093440012680951-7715Nonlinearity : (Bristol. Print)Nonlinearity : (Bristol. Print)Complete classDimension theoryEnergyFreedom degreeGraphGround stateHamiltonian systemJacobi methodLagrangian theoryMathematical physicsNonlinear analysisOne-dimensional calculationsOrderingTemperatureThermodynamic limitThoughtViscosity solutionZeroAnalyse non linéairePhysique mathématiqueEnergieCalcul 1 dimensionDegré libertéSystème hamiltonienRelation ordreThéorie lagrangienneSolution viscositéMéthode JacobiPenséeEtat fondamentalLimite thermodynamiqueTempératureZéroModèle discret05BxxThéorie Mather37JxxThéorie discrèteSolution discrète49L25Nombre rotationThéorie dimensionClasse complèteGraphe
We consider a generalization of the Frenkel-Kontorova model in higher dimension leading to a new theory of configurations with minimal energy, as in Aubry's theory or in Mather's twist approach in the periodic case. We consider a one-dimensional chain of particles and their minimizing configurations and we allow the state of each particle to possess many degrees of freedom. We assume that the Hamiltonian of the system satisfies some twist condition. The usual 'total ordering' of minimizing configurations does not exist any more and new tools need to be developed. The main mathematical tool is to cast the study of the minimizing configurations into the framework of discrete Lagrangian theory. We introduce forward and backward Lax-Oleinik problems and interpret their solutions as discrete viscosity solutions as in Hamilton-Jacobi methods. We give a fairly complete description of a particular class of minimizing configurations: the calibrated class. These configurations may be thought of as 'ground states' obtained in the thermodynamic limit at temperature zero. We obtain, in particular, Mather's graph property or the noncrossing property of two calibrated configurations and the existence of a rotation number for most of the calibrated configurations.
0951-7715Nonlinearity : (Bristol. Print)242Minimizing orbits in the discrete Aubry-Mather modelGARIBALDI (Eduardo)THIEULLEN (Philippe)Departamento de Matemática, Universidade Estadual de Campinas13083-859 Campinas - SPBRA1 aut.Institut de Mathématiques, Université Bordeaux 1, CNRS, UMR 525133405 TalenceFRA2 aut.563-6112011ENGINIST219053540001943579200800000© 2011 INIST-CNRS. All rights reserved.54 ref.11-0109344PANonlinearity : (Bristol. Print)GBRWe consider a generalization of the Frenkel-Kontorova model in higher dimension leading to a new theory of configurations with minimal energy, as in Aubry's theory or in Mather's twist approach in the periodic case. We consider a one-dimensional chain of particles and their minimizing configurations and we allow the state of each particle to possess many degrees of freedom. We assume that the Hamiltonian of the system satisfies some twist condition. The usual 'total ordering' of minimizing configurations does not exist any more and new tools need to be developed. The main mathematical tool is to cast the study of the minimizing configurations into the framework of discrete Lagrangian theory. We introduce forward and backward Lax-Oleinik problems and interpret their solutions as discrete viscosity solutions as in Hamilton-Jacobi methods. We give a fairly complete description of a particular class of minimizing configurations: the calibrated class. These configurations may be thought of as 'ground states' obtained in the thermodynamic limit at temperature zero. We obtain, in particular, Mather's graph property or the noncrossing property of two calibrated configurations and the existence of a rotation number for most of the calibrated configurations.001A02G04001B00B90001A02B01B001A02E18Analyse non linéaire01Nonlinear analysis01análisis no lineal01Physique mathématique02Mathematical physics02Física matemática02Energie17Energy17Energía17Calcul 1 dimension18One-dimensional calculations18Degré liberté19Freedom degree19Grado libertad19Système hamiltonien20Hamiltonian system20Sistema hamiltoniano20Relation ordre21Ordering21Relación orden21Théorie lagrangienne22Lagrangian theory22Teoría lagrangiana22Solution viscosité23Viscosity solution23Solución viscosidad23Méthode Jacobi24Jacobi method24Método Jacobi24Pensée25Thought25Pensamiento25Etat fondamental26Ground state26Estado fundamental26Limite thermodynamique27Thermodynamic limit27Límite termodinámico27Température28Temperature28Temperatura28Zéro29Zero29Cero29Modèle discretINC7005BxxINC71Théorie MatherINC7237JxxINC73Théorie discrèteINC74Solution discrèteINC7549L25INC76Nombre rotationINC77Théorie dimensionCD96Dimension theoryCD96Classe complèteCD97Complete classCD97GrapheCD98GraphCD98073OTOOTOPASCAL 11-0109344 INISTMinimizing orbits in the discrete Aubry-Mather modelGARIBALDI (Eduardo); THIEULLEN (Philippe)Departamento de Matemática, Universidade Estadual de Campinas/13083-859 Campinas - SP/Brésil (1 aut.); Institut de Mathématiques, Université Bordeaux 1, CNRS, UMR 5251/33405 Talence/France (2 aut.)
Publication en série; Niveau analytique
Nonlinearity : (Bristol. Print); ISSN 0951-7715; Royaume-Uni; Da. 2011; Vol. 24; No. 2; Pp. 563-611; Bibl. 54 ref.AnglaisWe consider a generalization of the Frenkel-Kontorova model in higher dimension leading to a new theory of configurations with minimal energy, as in Aubry's theory or in Mather's twist approach in the periodic case. We consider a one-dimensional chain of particles and their minimizing configurations and we allow the state of each particle to possess many degrees of freedom. We assume that the Hamiltonian of the system satisfies some twist condition. The usual 'total ordering' of minimizing configurations does not exist any more and new tools need to be developed. The main mathematical tool is to cast the study of the minimizing configurations into the framework of discrete Lagrangian theory. We introduce forward and backward Lax-Oleinik problems and interpret their solutions as discrete viscosity solutions as in Hamilton-Jacobi methods. We give a fairly complete description of a particular class of minimizing configurations: the calibrated class. These configurations may be thought of as 'ground states' obtained in the thermodynamic limit at temperature zero. We obtain, in particular, Mather's graph property or the noncrossing property of two calibrated configurations and the existence of a rotation number for most of the calibrated configurations.001A02G04; 001B00B90; 001A02B01B; 001A02E18Analyse non linéaire; Physique mathématique; Energie; Calcul 1 dimension; Degré liberté; Système hamiltonien; Relation ordre; Théorie lagrangienne; Solution viscosité; Méthode Jacobi; Pensée; Etat fondamental; Limite thermodynamique; Température; Zéro; Modèle discret; 05Bxx; Théorie Mather; 37Jxx; Théorie discrète; Solution discrète; 49L25; Nombre rotation; Théorie dimension; Classe complète; GrapheNonlinear analysis; Mathematical physics; Energy; One-dimensional calculations; Freedom degree; Hamiltonian system; Ordering; Lagrangian theory; Viscosity solution; Jacobi method; Thought; Ground state; Thermodynamic limit; Temperature; Zero; Dimension theory; Complete class; Graphanálisis no lineal; Física matemática; Energía; Grado libertad; Sistema hamiltoniano; Relación orden; Teoría lagrangiana; Solución viscosidad; Método Jacobi; Pensamiento; Estado fundamental; Límite termodinámico; Temperatura; CeroINIST-21905.35400019435792008011-0109344 001631 Invasion of Pontoscolex corethrurus (Glossoscolecidae, Oligochaeta) in landscapes of the Amazonian deforestation arcRaphael MarichalUniversité Pierre et Marie Curie and IRD, UMR BIOEMCO 211, Centre IRD Ile de France, 32 Av. Henri Varagnat93143 BONDYFRA1 aut.9 aut.10 aut.11 aut.14 aut.Coordenação de Zoologia, Museu Paraense Emilio Goeldi, Av. Perimetral, n 1901, CEP 66077-530, Terra Firme, BelémParaBRA1 aut.3 aut.Alex Feijoo MartinezUniversidad Tecnológica de Pereira, Apartado Aéreo 97 PereiraCOL2 aut.4 aut.5 aut.Catarina PraxedesCoordenação de Zoologia, Museu Paraense Emilio Goeldi, Av. Perimetral, n 1901, CEP 66077-530, Terra Firme, BelémParaBRA1 aut.3 aut.Dario RuizUniversidad Tecnológica de Pereira, Apartado Aéreo 97 PereiraCOL2 aut.4 aut.5 aut.Andres F. CarvajalUniversidad Tecnológica de Pereira, Apartado Aéreo 97 PereiraCOL2 aut.4 aut.5 aut.Johan OszwaldUMR CNRS LETG 6554, Laboratory of Geography and Remote Sensing COSTEL, Université de Rennes 2FRA6 aut.Maria Del Pilar HurtadoCentro Internacional de Agricultura Tropical (CIAT), TSBF LAC ap aereo 6713 CaliCOL7 aut.14 aut.George G. BrownEmbrapa Florestas, Estrada da Ribeira, Km. 111, GP. 319Colombo-PR 83411-000BRA8 aut.Michel GrimaldiUniversité Pierre et Marie Curie and IRD, UMR BIOEMCO 211, Centre IRD Ile de France, 32 Av. Henri Varagnat93143 BONDYFRA1 aut.9 aut.10 aut.11 aut.14 aut.Thierry DesjardinsUniversité Pierre et Marie Curie and IRD, UMR BIOEMCO 211, Centre IRD Ile de France, 32 Av. Henri Varagnat93143 BONDYFRA1 aut.9 aut.10 aut.11 aut.14 aut.Max SarrazinUniversité Pierre et Marie Curie and IRD, UMR BIOEMCO 211, Centre IRD Ile de France, 32 Av. Henri Varagnat93143 BONDYFRA1 aut.9 aut.10 aut.11 aut.14 aut.Thibaud DecaënsECODIV, Faculté des Sciences & des Techniques, Bâtiment IRESE A, Place Emile Blondel, Université de Rouen76821 Mont SaintAignanFRA12 aut.Elena VelasquezUniversidad Nacional de ColombiaPalmiraCOL13 aut.Patrick LavelleUniversité Pierre et Marie Curie and IRD, UMR BIOEMCO 211, Centre IRD Ile de France, 32 Av. Henri Varagnat93143 BONDYFRA1 aut.9 aut.10 aut.11 aut.14 aut.Centro Internacional de Agricultura Tropical (CIAT), TSBF LAC ap aereo 6713 CaliCOL7 aut.14 aut.11-01109042010PASCAL 11-0110904 INISTPascal:11-01109040012670929-1393Appl. soil ecol.Applied soil ecology : (Print)Amazon BasinDeforestationEarthwormEcologyInvasionLandscapeMacrofaunaSoil scienceInvasionPaysageDéboisementMacrofauneEcologieScience du solVer de terreBassin AmazonePontoscolex corethrurusGlossoscolecidae
Pontoscolex corethrurus (Glossoscolecidae, Oligochaeta) is an invasive endogeic earthworm that has colonized most land transformed by human activities in the humid tropics. When installed, populations can change soil physical properties, biogeochemical processes and microbial communities. The aim of this study was to determine whether P. corethrurus establishment is a result of (1) a competitive exclusion of native earthworm species or (2) the exploitation of a new niche created by anthropogenic disturbance that native earthworm species cannot use. We tested these hypotheses by doing a survey of earthworm communities in 270 sites that represented the diversity of land use systems encountered in two contrasted regions of the Amazonian arc of deforestation located in Brazil and Colombia respectively. When present in forests, P. corethrurus had no negative effect on the native species communities that had similar (epigeic species) or even higher densities (endogeic species) in the presence of the invasive species. These results suggest the absence of competitive exclusion. The first two axes of a PCA multivariate analysis of communities represented the densities of native species (axis 1) and P. corethrurus (axis 2) respectively. This suggests that respective densities of the two groups respond to different conditions and that their variations are independent. The density of P. corethrurus co-varied with soil N content and pH in Colombian sites while the densities of other species did not. Our results thus suggest that this invasive species, unlike native species, is able to feed and develop in environments where litter resources are decreased while soils have been enriched in C and nutrients by deforestation and burning. We discuss the reasons why some primary forests in Central America have large populations of P. corethrurus.
0929-1393Appl. soil ecol.463Invasion of Pontoscolex corethrurus (Glossoscolecidae, Oligochaeta) in landscapes of the Amazonian deforestation arcMARICHAL (Raphael)FEIJOO MARTINEZ (Alex)PRAXEDES (Catarina)RUIZ (Dario)CARVAJAL (Andres F.)OSZWALD (Johan)DEL PILAR HURTADO (Maria)BROWN (George G.)GRIMALDI (Michel)DESJARDINS (Thierry)SARRAZIN (Max)DECAËNS (Thibaud)VELASQUEZ (Elena)LAVELLE (Patrick)Université Pierre et Marie Curie and IRD, UMR BIOEMCO 211, Centre IRD Ile de France, 32 Av. Henri Varagnat93143 BONDYFRA1 aut.9 aut.10 aut.11 aut.14 aut.Universidad Tecnológica de Pereira, Apartado Aéreo 97 PereiraCOL2 aut.4 aut.5 aut.Coordenação de Zoologia, Museu Paraense Emilio Goeldi, Av. Perimetral, n 1901, CEP 66077-530, Terra Firme, BelémParaBRA1 aut.3 aut.UMR CNRS LETG 6554, Laboratory of Geography and Remote Sensing COSTEL, Université de Rennes 2FRA6 aut.Centro Internacional de Agricultura Tropical (CIAT), TSBF LAC ap aereo 6713 CaliCOL7 aut.14 aut.Embrapa Florestas, Estrada da Ribeira, Km. 111, GP. 319Colombo-PR 83411-000BRA8 aut.ECODIV, Faculté des Sciences & des Techniques, Bâtiment IRESE A, Place Emile Blondel, Université de Rouen76821 Mont SaintAignanFRA12 aut.Universidad Nacional de ColombiaPalmiraCOL13 aut.443-4492010ENGINIST269793540001936364801700000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0110904PAApplied soil ecology : (Print)GBRPontoscolex corethrurus (Glossoscolecidae, Oligochaeta) is an invasive endogeic earthworm that has colonized most land transformed by human activities in the humid tropics. When installed, populations can change soil physical properties, biogeochemical processes and microbial communities. The aim of this study was to determine whether P. corethrurus establishment is a result of (1) a competitive exclusion of native earthworm species or (2) the exploitation of a new niche created by anthropogenic disturbance that native earthworm species cannot use. We tested these hypotheses by doing a survey of earthworm communities in 270 sites that represented the diversity of land use systems encountered in two contrasted regions of the Amazonian arc of deforestation located in Brazil and Colombia respectively. When present in forests, P. corethrurus had no negative effect on the native species communities that had similar (epigeic species) or even higher densities (endogeic species) in the presence of the invasive species. These results suggest the absence of competitive exclusion. The first two axes of a PCA multivariate analysis of communities represented the densities of native species (axis 1) and P. corethrurus (axis 2) respectively. This suggests that respective densities of the two groups respond to different conditions and that their variations are independent. The density of P. corethrurus co-varied with soil N content and pH in Colombian sites while the densities of other species did not. Our results thus suggest that this invasive species, unlike native species, is able to feed and develop in environments where litter resources are decreased while soils have been enriched in C and nutrients by deforestation and burning. We discuss the reasons why some primary forests in Central America have large populations of P. corethrurus.002A32B03B4DInvasion01Invasion01Invasión01Paysage02Landscape02Paisaje02Déboisement03Deforestation03Deforestación03Macrofaune04Macrofauna04Macrofauna04Ecologie05Ecology05Ecología05Science du sol06Soil science06Ciencia del suelo06Ver de terre10Earthworm10Lombriz de tierra10Bassin AmazoneNG20Amazon BasinNG20Cuenca AmazonasNG20Pontoscolex corethrurusINC72GlossoscolecidaeINC73FauneFaunaFaunaOligochaetaNSOligochaetaNSOligochaetaNSAnnelidaNSAnnelidaNSAnnelidaNSInvertebrataNSInvertebrataNSInvertebrataNSAmérique du SudNGSouth AmericaNGAmerica del surNGAmériqueNGAmericaNGAmericaNGZone tropicale59Tropical zone59Zona tropical59073OTOOTOPASCAL 11-0110904 INISTInvasion of Pontoscolex corethrurus (Glossoscolecidae, Oligochaeta) in landscapes of the Amazonian deforestation arcMARICHAL (Raphael); FEIJOO MARTINEZ (Alex); PRAXEDES (Catarina); RUIZ (Dario); CARVAJAL (Andres F.); OSZWALD (Johan); DEL PILAR HURTADO (Maria); BROWN (George G.); GRIMALDI (Michel); DESJARDINS (Thierry); SARRAZIN (Max); DECAËNS (Thibaud); VELASQUEZ (Elena); LAVELLE (Patrick)Université Pierre et Marie Curie and IRD, UMR BIOEMCO 211, Centre IRD Ile de France, 32 Av. Henri Varagnat/93143 BONDY/France (1 aut., 9 aut., 10 aut., 11 aut., 14 aut.); Universidad Tecnológica de Pereira, Apartado Aéreo 97 Pereira/Colombie (2 aut., 4 aut., 5 aut.); Coordenação de Zoologia, Museu Paraense Emilio Goeldi, Av. Perimetral, n 1901, CEP 66077-530, Terra Firme, Belém/Para/Brésil (1 aut., 3 aut.); UMR CNRS LETG 6554, Laboratory of Geography and Remote Sensing COSTEL, Université de Rennes 2/France (6 aut.); Centro Internacional de Agricultura Tropical (CIAT), TSBF LAC ap aereo 6713 Cali/Colombie (7 aut., 14 aut.); Embrapa Florestas, Estrada da Ribeira, Km. 111, GP. 319/Colombo-PR 83411-000/Brésil (8 aut.); ECODIV, Faculté des Sciences & des Techniques, Bâtiment IRESE A, Place Emile Blondel, Université de Rouen/76821 Mont SaintAignan/France (12 aut.); Universidad Nacional de Colombia/Palmira/Colombie (13 aut.)
Publication en série; Niveau analytique
Applied soil ecology : (Print); ISSN 0929-1393; Royaume-Uni; Da. 2010; Vol. 46; No. 3; Pp. 443-449; Bibl. 3/4 p.AnglaisPontoscolex corethrurus (Glossoscolecidae, Oligochaeta) is an invasive endogeic earthworm that has colonized most land transformed by human activities in the humid tropics. When installed, populations can change soil physical properties, biogeochemical processes and microbial communities. The aim of this study was to determine whether P. corethrurus establishment is a result of (1) a competitive exclusion of native earthworm species or (2) the exploitation of a new niche created by anthropogenic disturbance that native earthworm species cannot use. We tested these hypotheses by doing a survey of earthworm communities in 270 sites that represented the diversity of land use systems encountered in two contrasted regions of the Amazonian arc of deforestation located in Brazil and Colombia respectively. When present in forests, P. corethrurus had no negative effect on the native species communities that had similar (epigeic species) or even higher densities (endogeic species) in the presence of the invasive species. These results suggest the absence of competitive exclusion. The first two axes of a PCA multivariate analysis of communities represented the densities of native species (axis 1) and P. corethrurus (axis 2) respectively. This suggests that respective densities of the two groups respond to different conditions and that their variations are independent. The density of P. corethrurus co-varied with soil N content and pH in Colombian sites while the densities of other species did not. Our results thus suggest that this invasive species, unlike native species, is able to feed and develop in environments where litter resources are decreased while soils have been enriched in C and nutrients by deforestation and burning. We discuss the reasons why some primary forests in Central America have large populations of P. corethrurus.002A32B03B4DInvasion; Paysage; Déboisement; Macrofaune; Ecologie; Science du sol; Ver de terre; Bassin Amazone; Pontoscolex corethrurus; GlossoscolecidaeFaune; Oligochaeta; Annelida; Invertebrata; Amérique du Sud; Amérique; Zone tropicaleInvasion; Landscape; Deforestation; Macrofauna; Ecology; Soil science; Earthworm; Amazon BasinFauna; Oligochaeta; Annelida; Invertebrata; South America; America; Tropical zoneInvasión; Paisaje; Deforestación; Macrofauna; Ecología; Ciencia del suelo; Lombriz de tierra; Cuenca AmazonasINIST-26979.35400019363648017011-0110904 001632 Multilocus Sequence Analysis and rpoB Sequencing of Mycobacterium abscessus (Sensu Lato) StrainsEdouard MacherasService de Microbiologie-Hygiène, Hôpital Ambroise Paré, Assistance Publique, Hôpitaux de Paris (AP-HP)Boulogne-BillancourtFRA1 aut.6 aut.13 aut.14 aut.EA 3647, Université de Versailles Saint-Quentin-en-YvelinesGarchesFRA1 aut.2 aut.6 aut.13 aut.14 aut.Anne-Laure RouxLaboratoire de Microbiologie, Hôpital Raymond Poincaré, AP-HPGarchesFRA2 aut.13 aut.EA 3647, Université de Versailles Saint-Quentin-en-YvelinesGarchesFRA1 aut.2 aut.6 aut.13 aut.14 aut.Sylvaine BastianCentre National de Référence des Mycobactéries et de la Résistance des Mycobactéries Aux Antituberculeux, Laboratoire de Bactériologie-Hygiène, Groupe Hospitalier Pitié-SalpêtrièreParisFRA3 aut.Sylvia Cardoso LeaoDepartamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São PauloSão PauloBRA4 aut.Moises PalaciNucleo de Doenças Infecciosas, Universidade Federal do Espírito SantoEspirito SantoBRA5 aut.Valérie Sivadon-TardyService de Microbiologie-Hygiène, Hôpital Ambroise Paré, Assistance Publique, Hôpitaux de Paris (AP-HP)Boulogne-BillancourtFRA1 aut.6 aut.13 aut.14 aut.EA 3647, Université de Versailles Saint-Quentin-en-YvelinesGarchesFRA1 aut.2 aut.6 aut.13 aut.14 aut.Cristina GutierrezFINDGenevaCHE7 aut.Elvira RichterNational Reference Center for Mycobacteria, Forschungszentrum BorstelBorstelDEU8 aut.9 aut.Sabine R Sch-GerdesNational Reference Center for Mycobacteria, Forschungszentrum BorstelBorstelDEU8 aut.9 aut.Gaby PfyflerInstitut fiir Medizinische Mikrobiologie, Zentrum für LaborMedizin, Luzemer KantonsspitalLuzernCHE10 aut.Thomas BodmerInstitut für Infektionskrankheiten, Universität BernBernCHE11 aut.Emmanuelle CambauCentre National de Référence des Mycobactéries et de la Résistance des Mycobactéries Aux Antituberculeux, Laboratoire Associé, Bactériologie-Virologie-Hygiène, Groupe Hospitalier Saint Louis-LariboisièreParisFRA12 aut.Jean-Louis GaillardService de Microbiologie-Hygiène, Hôpital Ambroise Paré, Assistance Publique, Hôpitaux de Paris (AP-HP)Boulogne-BillancourtFRA1 aut.6 aut.13 aut.14 aut.Laboratoire de Microbiologie, Hôpital Raymond Poincaré, AP-HPGarchesFRA2 aut.13 aut.EA 3647, Université de Versailles Saint-Quentin-en-YvelinesGarchesFRA1 aut.2 aut.6 aut.13 aut.14 aut.Beate HeymService de Microbiologie-Hygiène, Hôpital Ambroise Paré, Assistance Publique, Hôpitaux de Paris (AP-HP)Boulogne-BillancourtFRA1 aut.6 aut.13 aut.14 aut.EA 3647, Université de Versailles Saint-Quentin-en-YvelinesGarchesFRA1 aut.2 aut.6 aut.13 aut.14 aut.11-01119212011PASCAL 11-0111921 INISTPascal:11-01119210012660095-1137J. clin. microbiol. : (Print)Journal of clinical microbiology : (Print)Mycobacterium abscessusStrainMycobacterium abscessusSouche
Mycobacterium abscessus, Mycobacterium bolletii, and Mycobacterium massiliense (Mycobacterium abscessus sensu lato) are closely related species that currently are identified by the sequencing of the rpoB gene. However, recent studies show that rpoB sequencing alone is insufficient to discriminate between these species, and some authors have questioned their current taxonomic classification. We studied here a large collection of M. abscessus (sensu lato) strains by partial rpoB sequencing (752 bp) and multilocus sequence analysis (MLSA). The final MLSA scheme developed was based on the partial sequences of eight housekeeping genes: argH, cya, glpK, gnd, murC, pgm, pta, and purH. The strains studied included the three type strains (M. abscessus CIP 104536T, M. massiliense CIP 108297T, and M. bolletii CIP 108541T) and 120 isolates recovered between 1997 and 2007 in France, Germany, Switzerland, and Brazil. The rpoB phylogenetic tree confirmed the existence of three main clusters, each comprising the type strain of one species. However, divergence values between the M. massiliense and M. bolletii clusters all were below 3% and between the M. abscessus and M. massiliense clusters were from 2.66 to 3.59%. The tree produced using the concatenated MLSA gene sequences (4,071 bp) also showed three main clusters, each comprising the type strain of one species. The M. abscessus cluster had a bootstrap value of 100% and was mostly compact. Bootstrap values for the M. massiliense and M. bolletii branches were much lower (71 and 61%, respectively), with the M. massiliense cluster having a fuzzy aspect. Mean (range) divergence values were 2.17% (1.13 to 2.58%) between the M. abscessus and M. massiliense clusters, 2.37% (1.5 to 2.85%) between the M. abscessus and M. bolletii clusters, and 2.28% (0.86 to 2.68%) between the M. massiliense and M. bolletii clusters. Adding the rpoB sequence to the MLSA-concatenated sequence (total sequence, 4,823 bp) had little effect on the clustering of strains. We found 10/120 (8.3%) isolates for which the concatenated MLSA gene sequence and rpoB sequence were discordant (e.g., M. massiliense MLSA sequence and M. abscessus rpoB sequence), suggesting the intergroup lateral transfers of rpoB. In conclusion, our study strongly supports the recent proposal that M. abscessus, M. massiliense, and M. bolletii should constitute a single species. Our findings also indicate that there has been a horizontal transfer of rpoB sequences between these subgroups, precluding the use ofrpoB sequencing alone for the accurate identification of the two proposed M. abscessus subspecies.
0095-1137JCMIDWJ. clin. microbiol. : (Print)492Multilocus Sequence Analysis and rpoB Sequencing of Mycobacterium abscessus (Sensu Lato) StrainsMACHERAS (Edouard)ROUX (Anne-Laure)BASTIAN (Sylvaine)CARDOSO LEAO (Sylvia)PALACI (Moises)SIVADON-TARDY (Valérie)GUTIERREZ (Cristina)RICHTER (Elvira)RÜSCH-GERDES (Sabine)PFYFLER (Gaby)BODMER (Thomas)CAMBAU (Emmanuelle)GAILLARD (Jean-Louis)HEYM (Beate)Service de Microbiologie-Hygiène, Hôpital Ambroise Paré, Assistance Publique, Hôpitaux de Paris (AP-HP)Boulogne-BillancourtFRA1 aut.6 aut.13 aut.14 aut.Laboratoire de Microbiologie, Hôpital Raymond Poincaré, AP-HPGarchesFRA2 aut.13 aut.EA 3647, Université de Versailles Saint-Quentin-en-YvelinesGarchesFRA1 aut.2 aut.6 aut.13 aut.14 aut.Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries Aux Antituberculeux, Laboratoire de Bactériologie-Hygiène, Groupe Hospitalier Pitié-SalpêtrièreParisFRA3 aut.Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São PauloSão PauloBRA4 aut.Nucleo de Doenças Infecciosas, Universidade Federal do Espírito SantoEspirito SantoBRA5 aut.FINDGenevaCHE7 aut.National Reference Center for Mycobacteria, Forschungszentrum BorstelBorstelDEU8 aut.9 aut.Institut fiir Medizinische Mikrobiologie, Zentrum für LaborMedizin, Luzemer KantonsspitalLuzernCHE10 aut.Institut für Infektionskrankheiten, Universität BernBernCHE11 aut.Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries Aux Antituberculeux, Laboratoire Associé, Bactériologie-Virologie-Hygiène, Groupe Hospitalier Saint Louis-LariboisièreParisFRA12 aut.491-4992011ENGINIST170883540001919301100300000© 2011 INIST-CNRS. All rights reserved.60 ref.11-0111921PAJournal of clinical microbiology : (Print)USAMycobacterium abscessus, Mycobacterium bolletii, and Mycobacterium massiliense (Mycobacterium abscessus sensu lato) are closely related species that currently are identified by the sequencing of the rpoB gene. However, recent studies show that rpoB sequencing alone is insufficient to discriminate between these species, and some authors have questioned their current taxonomic classification. We studied here a large collection of M. abscessus (sensu lato) strains by partial rpoB sequencing (752 bp) and multilocus sequence analysis (MLSA). The final MLSA scheme developed was based on the partial sequences of eight housekeeping genes: argH, cya, glpK, gnd, murC, pgm, pta, and purH. The strains studied included the three type strains (M. abscessus CIP 104536T, M. massiliense CIP 108297T, and M. bolletii CIP 108541T) and 120 isolates recovered between 1997 and 2007 in France, Germany, Switzerland, and Brazil. The rpoB phylogenetic tree confirmed the existence of three main clusters, each comprising the type strain of one species. However, divergence values between the M. massiliense and M. bolletii clusters all were below 3% and between the M. abscessus and M. massiliense clusters were from 2.66 to 3.59%. The tree produced using the concatenated MLSA gene sequences (4,071 bp) also showed three main clusters, each comprising the type strain of one species. The M. abscessus cluster had a bootstrap value of 100% and was mostly compact. Bootstrap values for the M. massiliense and M. bolletii branches were much lower (71 and 61%, respectively), with the M. massiliense cluster having a fuzzy aspect. Mean (range) divergence values were 2.17% (1.13 to 2.58%) between the M. abscessus and M. massiliense clusters, 2.37% (1.5 to 2.85%) between the M. abscessus and M. bolletii clusters, and 2.28% (0.86 to 2.68%) between the M. massiliense and M. bolletii clusters. Adding the rpoB sequence to the MLSA-concatenated sequence (total sequence, 4,823 bp) had little effect on the clustering of strains. We found 10/120 (8.3%) isolates for which the concatenated MLSA gene sequence and rpoB sequence were discordant (e.g., M. massiliense MLSA sequence and M. abscessus rpoB sequence), suggesting the intergroup lateral transfers of rpoB. In conclusion, our study strongly supports the recent proposal that M. abscessus, M. massiliense, and M. bolletii should constitute a single species. Our findings also indicate that there has been a horizontal transfer of rpoB sequences between these subgroups, precluding the use ofrpoB sequencing alone for the accurate identification of the two proposed M. abscessus subspecies.002A05Mycobacterium abscessusNS01Mycobacterium abscessusNS01Mycobacterium abscessusNS01Souche05Strain05Cepa05MycobacteriaceaeNSMycobacteriaceaeNSMycobacteriaceaeNSMycobacterialesNSMycobacterialesNSMycobacterialesNSActinomycetesNSActinomycetesNSActinomycetesNSBactérieBacteriaBacteria073OTOOTOPASCAL 11-0111921 INISTMultilocus Sequence Analysis and rpoB Sequencing of Mycobacterium abscessus (Sensu Lato) StrainsMACHERAS (Edouard); ROUX (Anne-Laure); BASTIAN (Sylvaine); CARDOSO LEAO (Sylvia); PALACI (Moises); SIVADON-TARDY (Valérie); GUTIERREZ (Cristina); RICHTER (Elvira); RÜSCH-GERDES (Sabine); PFYFLER (Gaby); BODMER (Thomas); CAMBAU (Emmanuelle); GAILLARD (Jean-Louis); HEYM (Beate)Service de Microbiologie-Hygiène, Hôpital Ambroise Paré, Assistance Publique, Hôpitaux de Paris (AP-HP)/Boulogne-Billancourt/France (1 aut., 6 aut., 13 aut., 14 aut.); Laboratoire de Microbiologie, Hôpital Raymond Poincaré, AP-HP/Garches/France (2 aut., 13 aut.); EA 3647, Université de Versailles Saint-Quentin-en-Yvelines/Garches/France (1 aut., 2 aut., 6 aut., 13 aut., 14 aut.); Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries Aux Antituberculeux, Laboratoire de Bactériologie-Hygiène, Groupe Hospitalier Pitié-Salpêtrière/Paris/France (3 aut.); Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo/São Paulo/Brésil (4 aut.); Nucleo de Doenças Infecciosas, Universidade Federal do Espírito Santo/Espirito Santo/Brésil (5 aut.); FIND/Geneva/Suisse (7 aut.); National Reference Center for Mycobacteria, Forschungszentrum Borstel/Borstel/Allemagne (8 aut., 9 aut.); Institut fiir Medizinische Mikrobiologie, Zentrum für LaborMedizin, Luzemer Kantonsspital/Luzern/Suisse (10 aut.); Institut für Infektionskrankheiten, Universität Bern/Bern/Suisse (11 aut.); Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries Aux Antituberculeux, Laboratoire Associé, Bactériologie-Virologie-Hygiène, Groupe Hospitalier Saint Louis-Lariboisière/Paris/France (12 aut.)
Publication en série; Niveau analytique
Journal of clinical microbiology : (Print); ISSN 0095-1137; Coden JCMIDW; Etats-Unis; Da. 2011; Vol. 49; No. 2; Pp. 491-499; Bibl. 60 ref.AnglaisMycobacterium abscessus, Mycobacterium bolletii, and Mycobacterium massiliense (Mycobacterium abscessus sensu lato) are closely related species that currently are identified by the sequencing of the rpoB gene. However, recent studies show that rpoB sequencing alone is insufficient to discriminate between these species, and some authors have questioned their current taxonomic classification. We studied here a large collection of M. abscessus (sensu lato) strains by partial rpoB sequencing (752 bp) and multilocus sequence analysis (MLSA). The final MLSA scheme developed was based on the partial sequences of eight housekeeping genes: argH, cya, glpK, gnd, murC, pgm, pta, and purH. The strains studied included the three type strains (M. abscessus CIP 104536T, M. massiliense CIP 108297T, and M. bolletii CIP 108541T) and 120 isolates recovered between 1997 and 2007 in France, Germany, Switzerland, and Brazil. The rpoB phylogenetic tree confirmed the existence of three main clusters, each comprising the type strain of one species. However, divergence values between the M. massiliense and M. bolletii clusters all were below 3% and between the M. abscessus and M. massiliense clusters were from 2.66 to 3.59%. The tree produced using the concatenated MLSA gene sequences (4,071 bp) also showed three main clusters, each comprising the type strain of one species. The M. abscessus cluster had a bootstrap value of 100% and was mostly compact. Bootstrap values for the M. massiliense and M. bolletii branches were much lower (71 and 61%, respectively), with the M. massiliense cluster having a fuzzy aspect. Mean (range) divergence values were 2.17% (1.13 to 2.58%) between the M. abscessus and M. massiliense clusters, 2.37% (1.5 to 2.85%) between the M. abscessus and M. bolletii clusters, and 2.28% (0.86 to 2.68%) between the M. massiliense and M. bolletii clusters. Adding the rpoB sequence to the MLSA-concatenated sequence (total sequence, 4,823 bp) had little effect on the clustering of strains. We found 10/120 (8.3%) isolates for which the concatenated MLSA gene sequence and rpoB sequence were discordant (e.g., M. massiliense MLSA sequence and M. abscessus rpoB sequence), suggesting the intergroup lateral transfers of rpoB. In conclusion, our study strongly supports the recent proposal that M. abscessus, M. massiliense, and M. bolletii should constitute a single species. Our findings also indicate that there has been a horizontal transfer of rpoB sequences between these subgroups, precluding the use ofrpoB sequencing alone for the accurate identification of the two proposed M. abscessus subspecies.002A05Mycobacterium abscessus; SoucheMycobacteriaceae; Mycobacteriales; Actinomycetes; BactérieMycobacterium abscessus; StrainMycobacteriaceae; Mycobacteriales; Actinomycetes; BacteriaMycobacterium abscessus; CepaINIST-17088.35400019193011003011-0111921 001633 Pregnancy in women heterozygous for MCT8 mutations: risk of maternal hypothyroxinemia and fetal careHelton Estrela RamosINSERM U845FRA1 aut.3 aut.4 aut.14 aut.15 aut.Escola Bahiana de Medicina e Saúde PúblicaSalvador Bahia 40050-420BRA1 aut.Departamento de Pediatria da Faculdade de Medicina da Bahia, Universidade Federal da Bahia (UFBA), SalvadorBahia 40157-190BRA1 aut.Melina MorandiniPediatric Endocrinology and Gynecology, Centre des Maladies Endocriniennes Rares de la Croissance, AP-HP, Necker-Enfants Malades Hospital, Université Paris Descartes75743 ParisFRA2 aut.9 aut.14 aut.15 aut.Aurore CarreINSERM U845FRA1 aut.3 aut.4 aut.14 aut.15 aut.Elodie TronINSERM U845FRA1 aut.3 aut.4 aut.14 aut.15 aut.Corinne FlochPediatric Unit, Louis Mourier Hospital92701 ColombesFRA5 aut.7 aut.Laurent MandelbrotDepartment of Gynecology and Obstetric, Louis Mourier Hospital92701 ColombesFRA6 aut.Nathalie NeriPediatric Unit, Louis Mourier Hospital92701 ColombesFRA5 aut.7 aut.Benoit De SarcusDepartment of Gynecology and Obstetrics, Max Fourestier HospitalNanterre 92000FRA8 aut.Albane SimonPediatric Endocrinology and Gynecology, Centre des Maladies Endocriniennes Rares de la Croissance, AP-HP, Necker-Enfants Malades Hospital, Université Paris Descartes75743 ParisFRA2 aut.9 aut.14 aut.15 aut.Jean Paul BonnefontDepartment of Medical Genetics, Université Paris Descartes75743 ParisFRA10 aut.11 aut.Jeanne AmielDepartment of Medical Genetics, Université Paris Descartes75743 ParisFRA10 aut.11 aut.Isabelle DesguerreDepartment of Pediatric Neurology, Université Paris Descartes75743 ParisFRA12 aut.Vassili ValayannopoulosDepartment of Metabolic Diseases Department, Necker Enfants Malades Hospital, Université Paris Descartes75743 ParisFRA13 aut.Mireille CastanetINSERM U845FRA1 aut.3 aut.4 aut.14 aut.15 aut.Pediatric Endocrinology and Gynecology, Centre des Maladies Endocriniennes Rares de la Croissance, AP-HP, Necker-Enfants Malades Hospital, Université Paris Descartes75743 ParisFRA2 aut.9 aut.14 aut.15 aut.Michel PolakINSERM U845FRA1 aut.3 aut.4 aut.14 aut.15 aut.Pediatric Endocrinology and Gynecology, Centre des Maladies Endocriniennes Rares de la Croissance, AP-HP, Necker-Enfants Malades Hospital, Université Paris Descartes75743 ParisFRA2 aut.9 aut.14 aut.15 aut.11-01122482011PASCAL 11-0112248 INISTPascal:11-01122480012650804-4643Eur. j. endocrinol.European journal of endocrinologyAdultCareEndocrinologyFemaleFetusGeneticsHeterozygosityHumanMotherMutationPregnancyRiskRisk factorWomanGestationFemelleHommeFemmeAdulteHétérozygotieMutationGénétiqueFacteur risqueRisqueMèreFoetusSoinEndocrinologie
Context: Monocarboxylate transporter 8 (MCT8 or SLC16A2) mutations cause X-linked Allan-Herndon-Dudley syndrome. Heterozygous females are usually asymptomatic, but pregnancy may modify thyroid function and MCT8 is expressed in the placenta, suggesting that maternal and fetal abnormalities might develop even in the absence of MCT8 fetal mutation. Genetic counseling is so far based on X-linked transmission, and prenatal diagnosis is rarely performed. Objective: To describe thyroid function and the prenatal diagnosis in pregnant mothers harboring heterozygous MCT8 mutations and management of the persistent maternal hypothyroxinemia. Patients: Two women heterozygous for MCT8 mutations (c.1690G>A and c.1393-1G>C) were monitored throughout pregnancy. Methods: Prenatal diagnosis included sex determination, direct MCT8 sequencing, and familial linkage analysis. Ultrasonography and hormonal assays for maternal thyroid function evaluation were performed serially during pregnancy. Neonatal thyroid hormonal status was assessed. Results: None of the three fetuses (two males and one female) carried MCT8 mutations. One of the two heterozygous mothers revealed gestational hypothyroxinemia, prompting early levothyroxine (L-T4) therapy until delivery. The second heterozygous mother showed normal thyroid function but was preventively traited by L-T4 and all of the three neonates had normal thyroid hormone levels and thyroid gland at birth, suggesting advantages of prenatal care and/or compensatory mechanisms. Conclusion: Heterozygous MCT8 women should be monitored for requirement of L-T4 therapy to prevent fetal and neonatal hypothyroidism and to avoid risk of potential cognitive delay due to gestational hypothyroxinemia. Moreover, when the disease-causing mutation is known and/or the first child is affected, prenatal diagnosis for male fetuses should be assessed early for MCT8 mutations by direct sequencing.
0804-4643Eur. j. endocrinol.1642Pregnancy in women heterozygous for MCT8 mutations: risk of maternal hypothyroxinemia and fetal careESTRELA RAMOS (Helton)MORANDINI (Melina)CARRE (Aurore)TRON (Elodie)FLOCH (Corinne)MANDELBROT (Laurent)NERI (Nathalie)DE SARCUS (Benoit)SIMON (Albane)BONNEFONT (Jean Paul)AMIEL (Jeanne)DESGUERRE (Isabelle)VALAYANNOPOULOS (Vassili)CASTANET (Mireille)POLAK (Michel)INSERM U845FRA1 aut.3 aut.4 aut.14 aut.15 aut.Pediatric Endocrinology and Gynecology, Centre des Maladies Endocriniennes Rares de la Croissance, AP-HP, Necker-Enfants Malades Hospital, Université Paris Descartes75743 ParisFRA2 aut.9 aut.14 aut.15 aut.Escola Bahiana de Medicina e Saúde PúblicaSalvador Bahia 40050-420BRA1 aut.Departamento de Pediatria da Faculdade de Medicina da Bahia, Universidade Federal da Bahia (UFBA), SalvadorBahia 40157-190BRA1 aut.Pediatric Unit, Louis Mourier Hospital92701 ColombesFRA5 aut.7 aut.Department of Gynecology and Obstetric, Louis Mourier Hospital92701 ColombesFRA6 aut.Department of Gynecology and Obstetrics, Max Fourestier HospitalNanterre 92000FRA8 aut.Department of Medical Genetics, Université Paris Descartes75743 ParisFRA10 aut.11 aut.Department of Pediatric Neurology, Université Paris Descartes75743 ParisFRA12 aut.Department of Metabolic Diseases Department, Necker Enfants Malades Hospital, Université Paris Descartes75743 ParisFRA13 aut.309-3142011ENGINIST53213540001936471102100000© 2011 INIST-CNRS. All rights reserved.31 ref.11-0112248PECAEuropean journal of endocrinologyGBRContext: Monocarboxylate transporter 8 (MCT8 or SLC16A2) mutations cause X-linked Allan-Herndon-Dudley syndrome. Heterozygous females are usually asymptomatic, but pregnancy may modify thyroid function and MCT8 is expressed in the placenta, suggesting that maternal and fetal abnormalities might develop even in the absence of MCT8 fetal mutation. Genetic counseling is so far based on X-linked transmission, and prenatal diagnosis is rarely performed. Objective: To describe thyroid function and the prenatal diagnosis in pregnant mothers harboring heterozygous MCT8 mutations and management of the persistent maternal hypothyroxinemia. Patients: Two women heterozygous for MCT8 mutations (c.1690G>A and c.1393-1G>C) were monitored throughout pregnancy. Methods: Prenatal diagnosis included sex determination, direct MCT8 sequencing, and familial linkage analysis. Ultrasonography and hormonal assays for maternal thyroid function evaluation were performed serially during pregnancy. Neonatal thyroid hormonal status was assessed. Results: None of the three fetuses (two males and one female) carried MCT8 mutations. One of the two heterozygous mothers revealed gestational hypothyroxinemia, prompting early levothyroxine (L-T4) therapy until delivery. The second heterozygous mother showed normal thyroid function but was preventively traited by L-T4 and all of the three neonates had normal thyroid hormone levels and thyroid gland at birth, suggesting advantages of prenatal care and/or compensatory mechanisms. Conclusion: Heterozygous MCT8 women should be monitored for requirement of L-T4 therapy to prevent fetal and neonatal hypothyroidism and to avoid risk of potential cognitive delay due to gestational hypothyroxinemia. Moreover, when the disease-causing mutation is known and/or the first child is affected, prenatal diagnosis for male fetuses should be assessed early for MCT8 mutations by direct sequencing.002A28002B21Gestation02Pregnancy02Gestación02Femelle03Female03Hembra03Homme05Human05Hombre05Femme06Woman06Mujer06Adulte08Adult08Adulto08Hétérozygotie09Heterozygosity09Heterozigosis09Mutation11Mutation11Mutación11Génétique12Genetics12Genética12Facteur risque17Risk factor17Factor riesgo17Risque18Risk18Riesgo18Mère19Mother19Madre19Foetus20Fetus20Feto20Soin21Care21Cuidado21Endocrinologie22Endocrinology22Endocrinología22073OTOOTOPASCAL 11-0112248 INISTPregnancy in women heterozygous for MCT8 mutations: risk of maternal hypothyroxinemia and fetal careESTRELA RAMOS (Helton); MORANDINI (Melina); CARRE (Aurore); TRON (Elodie); FLOCH (Corinne); MANDELBROT (Laurent); NERI (Nathalie); DE SARCUS (Benoit); SIMON (Albane); BONNEFONT (Jean Paul); AMIEL (Jeanne); DESGUERRE (Isabelle); VALAYANNOPOULOS (Vassili); CASTANET (Mireille); POLAK (Michel)INSERM U845/France (1 aut., 3 aut., 4 aut., 14 aut., 15 aut.); Pediatric Endocrinology and Gynecology, Centre des Maladies Endocriniennes Rares de la Croissance, AP-HP, Necker-Enfants Malades Hospital, Université Paris Descartes/75743 Paris/France (2 aut., 9 aut., 14 aut., 15 aut.); Escola Bahiana de Medicina e Saúde Pública/Salvador Bahia 40050-420/Brésil (1 aut.); Departamento de Pediatria da Faculdade de Medicina da Bahia, Universidade Federal da Bahia (UFBA), Salvador/Bahia 40157-190/Brésil (1 aut.); Pediatric Unit, Louis Mourier Hospital/92701 Colombes/France (5 aut., 7 aut.); Department of Gynecology and Obstetric, Louis Mourier Hospital/92701 Colombes/France (6 aut.); Department of Gynecology and Obstetrics, Max Fourestier Hospital/Nanterre 92000/France (8 aut.); Department of Medical Genetics, Université Paris Descartes/75743 Paris/France (10 aut., 11 aut.); Department of Pediatric Neurology, Université Paris Descartes/75743 Paris/France (12 aut.); Department of Metabolic Diseases Department, Necker Enfants Malades Hospital, Université Paris Descartes/75743 Paris/France (13 aut.)
Publication en série; Etude de cas, cas et faits cliniques; Niveau analytique
European journal of endocrinology; ISSN 0804-4643; Royaume-Uni; Da. 2011; Vol. 164; No. 2; Pp. 309-314; Bibl. 31 ref.AnglaisContext: Monocarboxylate transporter 8 (MCT8 or SLC16A2) mutations cause X-linked Allan-Herndon-Dudley syndrome. Heterozygous females are usually asymptomatic, but pregnancy may modify thyroid function and MCT8 is expressed in the placenta, suggesting that maternal and fetal abnormalities might develop even in the absence of MCT8 fetal mutation. Genetic counseling is so far based on X-linked transmission, and prenatal diagnosis is rarely performed. Objective: To describe thyroid function and the prenatal diagnosis in pregnant mothers harboring heterozygous MCT8 mutations and management of the persistent maternal hypothyroxinemia. Patients: Two women heterozygous for MCT8 mutations (c.1690G>A and c.1393-1G>C) were monitored throughout pregnancy. Methods: Prenatal diagnosis included sex determination, direct MCT8 sequencing, and familial linkage analysis. Ultrasonography and hormonal assays for maternal thyroid function evaluation were performed serially during pregnancy. Neonatal thyroid hormonal status was assessed. Results: None of the three fetuses (two males and one female) carried MCT8 mutations. One of the two heterozygous mothers revealed gestational hypothyroxinemia, prompting early levothyroxine (L-T4) therapy until delivery. The second heterozygous mother showed normal thyroid function but was preventively traited by L-T4 and all of the three neonates had normal thyroid hormone levels and thyroid gland at birth, suggesting advantages of prenatal care and/or compensatory mechanisms. Conclusion: Heterozygous MCT8 women should be monitored for requirement of L-T4 therapy to prevent fetal and neonatal hypothyroidism and to avoid risk of potential cognitive delay due to gestational hypothyroxinemia. Moreover, when the disease-causing mutation is known and/or the first child is affected, prenatal diagnosis for male fetuses should be assessed early for MCT8 mutations by direct sequencing.002A28; 002B21Gestation; Femelle; Homme; Femme; Adulte; Hétérozygotie; Mutation; Génétique; Facteur risque; Risque; Mère; Foetus; Soin; EndocrinologiePregnancy; Female; Human; Woman; Adult; Heterozygosity; Mutation; Genetics; Risk factor; Risk; Mother; Fetus; Care; EndocrinologyGestación; Hembra; Hombre; Mujer; Adulto; Heterozigosis; Mutación; Genética; Factor riesgo; Riesgo; Madre; Feto; Cuidado; EndocrinologíaINIST-5321.35400019364711021011-0112248 001634 Understanding biogeobatteries: Where geophysics meets microbiology : Biogeophysics: Geophysical Signatures of Microbial Precesses in the EarthA. RevilDepartment of Geophysics, Colorado School of MinesGolden, ColoradoUSA1 aut.6 aut.LGIT, UMR 5559, Equipe Volcan, University of Savoie, CNRSLe Bourget-du-LacFRA1 aut.C. A. MendoncaGeofísica e Ciências Atmosféricas, Instituto de AstronomiaSao PauloBRA2 aut.E. A. AtekwanaBoone Pickens School of Geology, Oklahoma State UniversityStillwater, OklahomaUSA3 aut.B. KulessaSchool of the Environment and Society, Swansea UniversitySwanseaGBR4 aut.S. S. HubbardEarth Science Division, Lawrence Berkeley National LaboratoryBerkeley, CaliforniaUSA5 aut.K. J. BohlenDepartment of Geophysics, Colorado School of MinesGolden, ColoradoUSA1 aut.6 aut.11-01145862010PASCAL 11-0114586 INISTPascal:11-01145860012640148-0227J. geophys. res.Journal of geophysical researchactivation energyamplitudeanomaliesbacteriabridgesclayelectrical currentselectronsgeophysicsionsiron oxidesmaterialsmigrationmodelsplumespollutionpredictionGéophysiquePollutionPanacheCourant électriqueModèleIonElectronBactérieEnergie activationMigrationOxyde ferArgileMatériauPrévisionAmplitudePontAnomalie
[1] Although recent research suggests that contaminant plumes behave as geobatteries that produce an electrical current in the ground, no associated model exists that honors both geophysical and biogeochemical constraints. Here, we develop such a model to explain the two main electrochemical contributions to self-potential signals in contaminated areas. Both contributions are associated with the gradient of the activity of two types of charge carriers, ions and electrons. In the case of electrons, bacteria act as catalysts for reducing the activation energy needed to exchange the electrons between electron donors and electron acceptors. Possible mechanisms that facilitate electron migration include iron oxides, clays, and conductive biological materials, such as bacterial conductive pili or other conductive extracellular polymeric substances. Because we explicitly consider the role of biotic processes in the geobattery model, we coined the term "biogeobattery." Afrer theoretical development of the biogeobattery model, we compare model predictions with self-potential responses associated with laboratory and field scale investigations conducted in contaminated environments. We demonstrate that the amplitude and polarity of large (>100 mV) self-potential signatures requires the presence of an electronic conductor to serve as a bridge between electron donors and acceptors. Small self-potential anomalies imply that electron donors and electron acceptors are not directly interconnected, but instead result simply from the gradient of the activity of the ionic species that are present in the system.
0148-0227J. geophys. res.115G4Understanding biogeobatteries: Where geophysics meets microbiology : Biogeophysics: Geophysical Signatures of Microbial Precesses in the EarthREVIL (A.)MENDONCA (C. A.)ATEKWANA (E. A.)KULESSA (B.)HUBBARD (S. S.)BOHLEN (K. J.)Department of Geophysics, Colorado School of MinesGolden, ColoradoUSA1 aut.6 aut.LGIT, UMR 5559, Equipe Volcan, University of Savoie, CNRSLe Bourget-du-LacFRA1 aut.Geofísica e Ciências Atmosféricas, Instituto de AstronomiaSao PauloBRA2 aut.Boone Pickens School of Geology, Oklahoma State UniversityStillwater, OklahomaUSA3 aut.School of the Environment and Society, Swansea UniversitySwanseaGBR4 aut.Earth Science Division, Lawrence Berkeley National LaboratoryBerkeley, CaliforniaUSA5 aut.G00G02.1-G00G02.222010ENGINIST31443540001943871305800000© 2011 INIST-CNRS. All rights reserved.1 p.1/411-0114586PAJournal of geophysical researchUSA[1] Although recent research suggests that contaminant plumes behave as geobatteries that produce an electrical current in the ground, no associated model exists that honors both geophysical and biogeochemical constraints. Here, we develop such a model to explain the two main electrochemical contributions to self-potential signals in contaminated areas. Both contributions are associated with the gradient of the activity of two types of charge carriers, ions and electrons. In the case of electrons, bacteria act as catalysts for reducing the activation energy needed to exchange the electrons between electron donors and electron acceptors. Possible mechanisms that facilitate electron migration include iron oxides, clays, and conductive biological materials, such as bacterial conductive pili or other conductive extracellular polymeric substances. Because we explicitly consider the role of biotic processes in the geobattery model, we coined the term "biogeobattery." Afrer theoretical development of the biogeobattery model, we compare model predictions with self-potential responses associated with laboratory and field scale investigations conducted in contaminated environments. We demonstrate that the amplitude and polarity of large (>100 mV) self-potential signatures requires the presence of an electronic conductor to serve as a bridge between electron donors and acceptors. Small self-potential anomalies imply that electron donors and electron acceptors are not directly interconnected, but instead result simply from the gradient of the activity of the ionic species that are present in the system.001E001E01220Géophysique01geophysics01Geofísica01Pollution02pollution02Polución02Panache03plumes03Penacho03Courant électrique04electrical currents04Corriente eléctrica04Modèle05models05Modelo05Ion06ions06Ión06Electron07electrons07Electrón07BactérieNY08bacteriaNY08Energie activation09activation energy09Energía activación09Migration10migration10Migración10Oxyde ferNZ11iron oxidesNZ11Óxido de hierroNZ11ArgileNV12clayNV12ArcillaNV12Matériau13materials13Prévision14prediction14Previsión14Amplitude15amplitude15Amplitud15Pont16bridges16Puente16Anomalie17anomalies17Anomalía17ProcaryoteNYprokaryotesNYOxydeNZoxidesNZÓxidoNZRoche clastiqueNVclastic rocksNVRoca clásticaNVRoche sédimentaireNVsedimentary rocksNVRoca sedimentariaNV073OTOOTOPASCAL 11-0114586 INISTUnderstanding biogeobatteries: Where geophysics meets microbiology : Biogeophysics: Geophysical Signatures of Microbial Precesses in the EarthREVIL (A.); MENDONCA (C. A.); ATEKWANA (E. A.); KULESSA (B.); HUBBARD (S. S.); BOHLEN (K. J.)Department of Geophysics, Colorado School of Mines/Golden, Colorado/Etats-Unis (1 aut., 6 aut.); LGIT, UMR 5559, Equipe Volcan, University of Savoie, CNRS/Le Bourget-du-Lac/France (1 aut.); Geofísica e Ciências Atmosféricas, Instituto de Astronomia/Sao Paulo/Brésil (2 aut.); Boone Pickens School of Geology, Oklahoma State University/Stillwater, Oklahoma/Etats-Unis (3 aut.); School of the Environment and Society, Swansea University/Swansea/Royaume-Uni (4 aut.); Earth Science Division, Lawrence Berkeley National Laboratory/Berkeley, California/Etats-Unis (5 aut.)
Publication en série; Niveau analytique
Journal of geophysical research; ISSN 0148-0227; Etats-Unis; Da. 2010; Vol. 115; No. G4; G00G02.1-G00G02.22; Bibl. 1 p.1/4Anglais[1] Although recent research suggests that contaminant plumes behave as geobatteries that produce an electrical current in the ground, no associated model exists that honors both geophysical and biogeochemical constraints. Here, we develop such a model to explain the two main electrochemical contributions to self-potential signals in contaminated areas. Both contributions are associated with the gradient of the activity of two types of charge carriers, ions and electrons. In the case of electrons, bacteria act as catalysts for reducing the activation energy needed to exchange the electrons between electron donors and electron acceptors. Possible mechanisms that facilitate electron migration include iron oxides, clays, and conductive biological materials, such as bacterial conductive pili or other conductive extracellular polymeric substances. Because we explicitly consider the role of biotic processes in the geobattery model, we coined the term "biogeobattery." Afrer theoretical development of the biogeobattery model, we compare model predictions with self-potential responses associated with laboratory and field scale investigations conducted in contaminated environments. We demonstrate that the amplitude and polarity of large (>100 mV) self-potential signatures requires the presence of an electronic conductor to serve as a bridge between electron donors and acceptors. Small self-potential anomalies imply that electron donors and electron acceptors are not directly interconnected, but instead result simply from the gradient of the activity of the ionic species that are present in the system.001E; 001E01; 220Géophysique; Pollution; Panache; Courant électrique; Modèle; Ion; Electron; Bactérie; Energie activation; Migration; Oxyde fer; Argile; Matériau; Prévision; Amplitude; Pont; AnomalieProcaryote; Oxyde; Roche clastique; Roche sédimentairegeophysics; pollution; plumes; electrical currents; models; ions; electrons; bacteria; activation energy; migration; iron oxides; clay; materials; prediction; amplitude; bridges; anomaliesprokaryotes; oxides; clastic rocks; sedimentary rocksGeofísica; Polución; Penacho; Corriente eléctrica; Modelo; Ión; Electrón; Energía activación; Migración; Óxido de hierro; Arcilla; Previsión; Amplitud; Puente; AnomalíaINIST-3144.35400019438713058011-0114586 001635 Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infectionI. Martin-LoechesCritical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes)TarragonaESP1 aut.2 aut.T. LisboaCritical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes)TarragonaESP1 aut.2 aut.Critical Care Department, Hospital de Clinicas de Porto AlegrePorto AlegreBRA2 aut.A. RhodesCritical Care Department, St. George's Healthcare NHS TrustLondonGBR3 aut.R. P. MorenoUnidade de Cuidados Intensivos Polivalente, Hospital de St. António dos Capuchos, Centro Hospitalar de Lisboa Central, E.P.E.LisbonPRT4 aut.12 aut.E. SilvaICU, Hospital Israelita Albert EinsteinSão PauloBRA5 aut.C. SprungDepartment of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical CenterJerusalemISR6 aut.J. D. ChicheService de Réanimation Médicale, Hôpital Cochin (AP-HP), Université Paris Descartes, Unité Inserm U56775014 PrisFRA7 aut.D. BarahonaUnidad de Cuidados Intensivos, Hospital Eugenio EspejoQuitoECU8 aut.M. VillabonUnidad de Cuidados Intensivos, Hospital de San JoséBogotáCOL9 aut.C. BalasiniUnidad de Cuidados Intensivos, Hospital San Martin, La PlataBuenos AiresARG10 aut.R. M. PearseBarts and The London School of Medicine and Dentistry, Queen Mary's University of London Royal London HospitalLondonGBR11 aut.R. MatosUnidade de Cuidados Intensivos Polivalente, Hospital de St. António dos Capuchos, Centro Hospitalar de Lisboa Central, E.P.E.LisbonPRT4 aut.12 aut.J. RelloCritical Care Department, Vall d'Hebron University Hospital, Institut de Recerca Vall D'Hebron, University Autonoma Barcelona, CIBER Enfermedades Respiratorias (CIBERes), Passeig de la Vall d'Hebron 119-12908035 BarcelonaESP13 aut.11-01146582011PASCAL 11-0114658 INISTPascal:11-01146580012630342-4642Intensive care med. : (Print)Intensive care medicine : (Print)Community acquired infectionCorticosteroidH1N1 influenzaHumanInfluenza AIntensive carePneumoniaResuscitationTreatmentPneumonieInfection communautaireCorticostéroïdeTraitementHommeGrippe ARéanimationSoin intensifGrippe H1N1
Introduction: Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection, although relatively common, remains controversial. Methods: Prospective, observational, multicenter study from 23 June 2009 through 11 February 2010, reported in the European Society of Intensive Care Medicine (ESICM) H1N1 registry. Results: Two hundred twenty patients admitted to an intensive care unit (ICU) with completed outcome data were analyzed. Invasive mechanical ventilation was used in 155 (70.5%). Sixty-seven (30.5%) of the patients died in ICU and 75 (34.1%) whilst in hospital. One hundred twenty-six (57.3%) patients received corticosteroid therapy on admission to ICU. Patients who received corticosteroids were significantly older and were more likely to have coexisting asthma, chronic obstructive pulmonary disease (COPD), and chronic steroid use. These patients receiving corticosteroids had increased likelihood of developing hospital-acquired pneumonia (HAP) [26.2% versus 13.8%, p < 0.05; odds ratio (OR) 2.2, confidence interval (CI) 1. 1-4.5]. Patients who received corticosteroids had significantly higher ICU mortality than patients who did not (46.0% versus 18.1%, p < 0.01; OR 3.8, CI 2.1-7.2). Cox regression analysis adjusted for severity and potential confounding factors identified that early use of corticosteroids was not significantly associated with mortality [hazard ratio (HR) 1.3, 95% CI 0.7-2.4, p = 0.4] but was still associated with an increased rate of HAP (OR 2.2, 95% CI 1.0-4.8, p < 0.05). When only patients developing acute respiratory distress syndrome (ARDS) were analyzed, similar results were observed. Conclusions: Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection did not result in better outcomes and was associated with increased risk of superinfections.
0342-4642ICMED9Intensive care med. : (Print)372Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infectionMARTIN-LOECHES (I.)LISBOA (T.)RHODES (A.)MORENO (R. P.)SILVA (E.)SPRUNG (C.)CHICHE (J. D.)BARAHONA (D.)VILLABON (M.)BALASINI (C.)PEARSE (R. M.)MATOS (R.)RELLO (J.)Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes)TarragonaESP1 aut.2 aut.Critical Care Department, Hospital de Clinicas de Porto AlegrePorto AlegreBRA2 aut.Critical Care Department, St. George's Healthcare NHS TrustLondonGBR3 aut.Unidade de Cuidados Intensivos Polivalente, Hospital de St. António dos Capuchos, Centro Hospitalar de Lisboa Central, E.P.E.LisbonPRT4 aut.12 aut.ICU, Hospital Israelita Albert EinsteinSão PauloBRA5 aut.Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical CenterJerusalemISR6 aut.Service de Réanimation Médicale, Hôpital Cochin (AP-HP), Université Paris Descartes, Unité Inserm U56775014 PrisFRA7 aut.Unidad de Cuidados Intensivos, Hospital Eugenio EspejoQuitoECU8 aut.Unidad de Cuidados Intensivos, Hospital de San JoséBogotáCOL9 aut.Unidad de Cuidados Intensivos, Hospital San Martin, La PlataBuenos AiresARG10 aut.Barts and The London School of Medicine and Dentistry, Queen Mary's University of London Royal London HospitalLondonGBR11 aut.Critical Care Department, Vall d'Hebron University Hospital, Institut de Recerca Vall D'Hebron, University Autonoma Barcelona, CIBER Enfermedades Respiratorias (CIBERes), Passeig de la Vall d'Hebron 119-12908035 BarcelonaESP13 aut.ESICM H1N1 Registry ContributorsINC272-2832011ENGINIST162563540001943908301300000© 2011 INIST-CNRS. All rights reserved.55 ref.11-0114658PAIntensive care medicine : (Print)DEUIntroduction: Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection, although relatively common, remains controversial. Methods: Prospective, observational, multicenter study from 23 June 2009 through 11 February 2010, reported in the European Society of Intensive Care Medicine (ESICM) H1N1 registry. Results: Two hundred twenty patients admitted to an intensive care unit (ICU) with completed outcome data were analyzed. Invasive mechanical ventilation was used in 155 (70.5%). Sixty-seven (30.5%) of the patients died in ICU and 75 (34.1%) whilst in hospital. One hundred twenty-six (57.3%) patients received corticosteroid therapy on admission to ICU. Patients who received corticosteroids were significantly older and were more likely to have coexisting asthma, chronic obstructive pulmonary disease (COPD), and chronic steroid use. These patients receiving corticosteroids had increased likelihood of developing hospital-acquired pneumonia (HAP) [26.2% versus 13.8%, p < 0.05; odds ratio (OR) 2.2, confidence interval (CI) 1. 1-4.5]. Patients who received corticosteroids had significantly higher ICU mortality than patients who did not (46.0% versus 18.1%, p < 0.01; OR 3.8, CI 2.1-7.2). Cox regression analysis adjusted for severity and potential confounding factors identified that early use of corticosteroids was not significantly associated with mortality [hazard ratio (HR) 1.3, 95% CI 0.7-2.4, p = 0.4] but was still associated with an increased rate of HAP (OR 2.2, 95% CI 1.0-4.8, p < 0.05). When only patients developing acute respiratory distress syndrome (ARDS) were analyzed, similar results were observed. Conclusions: Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection did not result in better outcomes and was associated with increased risk of superinfections.002B27B002B27B10Pneumonie01Pneumonia01Neumonía01Infection communautaireNM02Community acquired infectionNM02Infección comunitariaNM02Corticostéroïde09Corticosteroid09Corticoesteroide09Traitement10Treatment10Tratamiento10Homme11Human11Hombre11Grippe A12Influenza A12Gripe A12Réanimation13Resuscitation13Reanimación13Soin intensif14Intensive care14Cuidado intensivo14Grippe H1N1CD96H1N1 influenzaCD96Gripe H1N1CD96ViroseViral diseaseVirosisInfectionInfectionInfecciónPathologie de l'appareil respiratoire37Respiratory disease37Aparato respiratorio patología37Pathologie des poumons39Lung disease39Pulmón patología39073OTOOTOPASCAL 11-0114658 INISTUse of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infectionMARTIN-LOECHES (I.); LISBOA (T.); RHODES (A.); MORENO (R. P.); SILVA (E.); SPRUNG (C.); CHICHE (J. D.); BARAHONA (D.); VILLABON (M.); BALASINI (C.); PEARSE (R. M.); MATOS (R.); RELLO (J.)Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes)/Tarragona/Espagne (1 aut., 2 aut.); Critical Care Department, Hospital de Clinicas de Porto Alegre/Porto Alegre/Brésil (2 aut.); Critical Care Department, St. George's Healthcare NHS Trust/London/Royaume-Uni (3 aut.); Unidade de Cuidados Intensivos Polivalente, Hospital de St. António dos Capuchos, Centro Hospitalar de Lisboa Central, E.P.E./Lisbon/Portugal (4 aut., 12 aut.); ICU, Hospital Israelita Albert Einstein/São Paulo/Brésil (5 aut.); Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center/Jerusalem/Israël (6 aut.); Service de Réanimation Médicale, Hôpital Cochin (AP-HP), Université Paris Descartes, Unité Inserm U567/75014 Pris/France (7 aut.); Unidad de Cuidados Intensivos, Hospital Eugenio Espejo/Quito/Equateur (8 aut.); Unidad de Cuidados Intensivos, Hospital de San José/Bogotá/Colombie (9 aut.); Unidad de Cuidados Intensivos, Hospital San Martin, La Plata/Buenos Aires/Argentine (10 aut.); Barts and The London School of Medicine and Dentistry, Queen Mary's University of London Royal London Hospital/London/Royaume-Uni (11 aut.); Critical Care Department, Vall d'Hebron University Hospital, Institut de Recerca Vall D'Hebron, University Autonoma Barcelona, CIBER Enfermedades Respiratorias (CIBERes), Passeig de la Vall d'Hebron 119-129/08035 Barcelona/Espagne (13 aut.)
Publication en série; Niveau analytique
Intensive care medicine : (Print); ISSN 0342-4642; Coden ICMED9; Allemagne; Da. 2011; Vol. 37; No. 2; Pp. 272-283; Bibl. 55 ref.AnglaisIntroduction: Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection, although relatively common, remains controversial. Methods: Prospective, observational, multicenter study from 23 June 2009 through 11 February 2010, reported in the European Society of Intensive Care Medicine (ESICM) H1N1 registry. Results: Two hundred twenty patients admitted to an intensive care unit (ICU) with completed outcome data were analyzed. Invasive mechanical ventilation was used in 155 (70.5%). Sixty-seven (30.5%) of the patients died in ICU and 75 (34.1%) whilst in hospital. One hundred twenty-six (57.3%) patients received corticosteroid therapy on admission to ICU. Patients who received corticosteroids were significantly older and were more likely to have coexisting asthma, chronic obstructive pulmonary disease (COPD), and chronic steroid use. These patients receiving corticosteroids had increased likelihood of developing hospital-acquired pneumonia (HAP) [26.2% versus 13.8%, p < 0.05; odds ratio (OR) 2.2, confidence interval (CI) 1. 1-4.5]. Patients who received corticosteroids had significantly higher ICU mortality than patients who did not (46.0% versus 18.1%, p < 0.01; OR 3.8, CI 2.1-7.2). Cox regression analysis adjusted for severity and potential confounding factors identified that early use of corticosteroids was not significantly associated with mortality [hazard ratio (HR) 1.3, 95% CI 0.7-2.4, p = 0.4] but was still associated with an increased rate of HAP (OR 2.2, 95% CI 1.0-4.8, p < 0.05). When only patients developing acute respiratory distress syndrome (ARDS) were analyzed, similar results were observed. Conclusions: Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection did not result in better outcomes and was associated with increased risk of superinfections.002B27B; 002B27B10Pneumonie; Infection communautaire; Corticostéroïde; Traitement; Homme; Grippe A; Réanimation; Soin intensif; Grippe H1N1Virose; Infection; Pathologie de l'appareil respiratoire; Pathologie des poumonsPneumonia; Community acquired infection; Corticosteroid; Treatment; Human; Influenza A; Resuscitation; Intensive care; H1N1 influenzaViral disease; Infection; Respiratory disease; Lung diseaseNeumonía; Infección comunitaria; Corticoesteroide; Tratamiento; Hombre; Gripe A; Reanimación; Cuidado intensivo; Gripe H1N1INIST-16256.35400019439083013011-0114658 001636 Short-term survival by treatment among patients hospitalized with acute heart failure: the global ALARM-HF registry using propensity scoring methodsAlexandre MebazaaDepartment of Anesthesiology and Critical Care Medicine, Hôpital Lariboisère, L'Assistance Publique-Hôpitaux de Paris (AP-HP)ParisFRA1 aut.4 aut.UMR-S 942 InsermParisFRA1 aut.Univ Paris DiderotParisFRA1 aut.3 aut.4 aut.John ParissisHeart Failure Clinic and Second Cardiology Department, Attikon University HospitalAthensGRC2 aut.5 aut.Raphael PorcherUniv Paris DiderotParisFRA1 aut.3 aut.4 aut.Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, AP-HPParisFRA3 aut.UMR-S 717, InsermParisFRA3 aut.4 aut.Etienne GayatDepartment of Anesthesiology and Critical Care Medicine, Hôpital Lariboisère, L'Assistance Publique-Hôpitaux de Paris (AP-HP)ParisFRA1 aut.4 aut.Univ Paris DiderotParisFRA1 aut.3 aut.4 aut.UMR-S 717, InsermParisFRA3 aut.4 aut.Maria NikolaouHeart Failure Clinic and Second Cardiology Department, Attikon University HospitalAthensGRC2 aut.5 aut.Fabio Vilas BoasCardiology Division and Heart Failure and Transplantation Program, Hospital EspanholSalvador, BahiaBRA6 aut.J. F. DelgadoHeart Failure and Transplant Unit, Cardiology Department, Hospital Doce de OctubreMadridESP7 aut.Ferenc FollathDepartment of Internal Medicine, University Hospital ZurichZurichCHE8 aut.11-01146912011PASCAL 11-0114691 INISTPascal:11-01146910012620342-4642Intensive care med. : (Print)Intensive care medicine : (Print)AlarmHeart failureHumanIntensive careIntravenous administrationResuscitationShort termSurvivalTreatmentInsuffisance cardiaqueCourt termeSurvieTraitementHommeAlarmeVoie intraveineuseRéanimationSoin intensif
Purpose: To date, treatment with intravenous (IV) agents such as vasodilators, diuretics, and inotropes has shown marginal or mixed benefits in acute heart failure (AHF) trials. The aim of this study was to identify the risks and benefits of IV drugs in patients hospitalized with acute decompensated heart failure. Methods: The AHF global survey of standard treatment (ALARM-HF) reviewed in-hospital treatments in eight countries. The present study was a post hoc analysis of ALARM-HF data in which propensity scoring was used to identify groups of patients who differed by treatment but had the same multivariate distribution of covariates. Such propensity matching allowed estimations of the effect of specific treatments on the outcome of in-hospital mortality. Results: Unadjusted analysis showed a lower in-hospital mortality rate in AHF patients receiving "diuretics + vasodilators" (n = 1,805) compared to those receiving "diuretics alone" (n = 2,362) (7.6 vs. 14.2%, p < 0.0001). Propensity-based matching (n = 1,007 matched pairs) confirmed the lower mortality of AHF patients receiving diuretics + vasodilators: 7.8 versus 11.0% (p = 0.016). Unadjusted analysis showed a much greater in-hospital mortality rate in patients receiving IV inotropes (25.9%) compared to those who did not (5.2%) (p < 0.0001). Propensity-based matching (n = 954 pairs) confirmed that IV catecholamine use was associated with 1.5-fold increase for dopamine or dobutamine use and a >2.5-fold increase for norepinephrine or epinephrine use. Conclusions: In terms of in-hospital survival, a vasodilator in combination with a diuretic fared better than treatment with only a diuretic. Catecholamine inotropes should be used cautiously as it has been seen that they actually increase the risk for in-hospital mortality.
0342-4642ICMED9Intensive care med. : (Print)372Short-term survival by treatment among patients hospitalized with acute heart failure: the global ALARM-HF registry using propensity scoring methodsMEBAZAA (Alexandre)PARISSIS (John)PORCHER (Raphael)GAYAT (Etienne)NIKOLAOU (Maria)VILAS BOAS (Fabio)DELGADO (J. F.)FOLLATH (Ferenc)Department of Anesthesiology and Critical Care Medicine, Hôpital Lariboisère, L'Assistance Publique-Hôpitaux de Paris (AP-HP)ParisFRA1 aut.4 aut.UMR-S 942 InsermParisFRA1 aut.Univ Paris DiderotParisFRA1 aut.3 aut.4 aut.Heart Failure Clinic and Second Cardiology Department, Attikon University HospitalAthensGRC2 aut.5 aut.Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, AP-HPParisFRA3 aut.UMR-S 717, InsermParisFRA3 aut.4 aut.Cardiology Division and Heart Failure and Transplantation Program, Hospital EspanholSalvador, BahiaBRA6 aut.Heart Failure and Transplant Unit, Cardiology Department, Hospital Doce de OctubreMadridESP7 aut.Department of Internal Medicine, University Hospital ZurichZurichCHE8 aut.290-3012011ENGINIST162563540001943908301500000© 2011 INIST-CNRS. All rights reserved.39 ref.11-0114691PAIntensive care medicine : (Print)DEUPurpose: To date, treatment with intravenous (IV) agents such as vasodilators, diuretics, and inotropes has shown marginal or mixed benefits in acute heart failure (AHF) trials. The aim of this study was to identify the risks and benefits of IV drugs in patients hospitalized with acute decompensated heart failure. Methods: The AHF global survey of standard treatment (ALARM-HF) reviewed in-hospital treatments in eight countries. The present study was a post hoc analysis of ALARM-HF data in which propensity scoring was used to identify groups of patients who differed by treatment but had the same multivariate distribution of covariates. Such propensity matching allowed estimations of the effect of specific treatments on the outcome of in-hospital mortality. Results: Unadjusted analysis showed a lower in-hospital mortality rate in AHF patients receiving "diuretics + vasodilators" (n = 1,805) compared to those receiving "diuretics alone" (n = 2,362) (7.6 vs. 14.2%, p < 0.0001). Propensity-based matching (n = 1,007 matched pairs) confirmed the lower mortality of AHF patients receiving diuretics + vasodilators: 7.8 versus 11.0% (p = 0.016). Unadjusted analysis showed a much greater in-hospital mortality rate in patients receiving IV inotropes (25.9%) compared to those who did not (5.2%) (p < 0.0001). Propensity-based matching (n = 954 pairs) confirmed that IV catecholamine use was associated with 1.5-fold increase for dopamine or dobutamine use and a >2.5-fold increase for norepinephrine or epinephrine use. Conclusions: In terms of in-hospital survival, a vasodilator in combination with a diuretic fared better than treatment with only a diuretic. Catecholamine inotropes should be used cautiously as it has been seen that they actually increase the risk for in-hospital mortality.002B27B002B27B01Insuffisance cardiaque01Heart failure01Insuficiencia cardíaca01Court terme09Short term09Corto plazo09Survie10Survival10Sobrevivencia10Traitement11Treatment11Tratamiento11Homme12Human12Hombre12Alarme13Alarm13Alarma13Voie intraveineuse14Intravenous administration14Vía intravenosa14Réanimation15Resuscitation15Reanimación15Soin intensif16Intensive care16Cuidado intensivo16Pathologie de l'appareil circulatoire37Cardiovascular disease37Aparato circulatorio patología37Cardiopathie38Heart disease38Cardiopatía38073OTOOTOPASCAL 11-0114691 INISTShort-term survival by treatment among patients hospitalized with acute heart failure: the global ALARM-HF registry using propensity scoring methodsMEBAZAA (Alexandre); PARISSIS (John); PORCHER (Raphael); GAYAT (Etienne); NIKOLAOU (Maria); VILAS BOAS (Fabio); DELGADO (J. F.); FOLLATH (Ferenc)Department of Anesthesiology and Critical Care Medicine, Hôpital Lariboisère, L'Assistance Publique-Hôpitaux de Paris (AP-HP)/Paris/France (1 aut., 4 aut.); UMR-S 942 Inserm/Paris/France (1 aut.); Univ Paris Diderot/Paris/France (1 aut., 3 aut., 4 aut.); Heart Failure Clinic and Second Cardiology Department, Attikon University Hospital/Athens/Grèce (2 aut., 5 aut.); Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, AP-HP/Paris/France (3 aut.); UMR-S 717, Inserm/Paris/France (3 aut., 4 aut.); Cardiology Division and Heart Failure and Transplantation Program, Hospital Espanhol/Salvador, Bahia/Brésil (6 aut.); Heart Failure and Transplant Unit, Cardiology Department, Hospital Doce de Octubre/Madrid/Espagne (7 aut.); Department of Internal Medicine, University Hospital Zurich/Zurich/Suisse (8 aut.)
Publication en série; Niveau analytique
Intensive care medicine : (Print); ISSN 0342-4642; Coden ICMED9; Allemagne; Da. 2011; Vol. 37; No. 2; Pp. 290-301; Bibl. 39 ref.AnglaisPurpose: To date, treatment with intravenous (IV) agents such as vasodilators, diuretics, and inotropes has shown marginal or mixed benefits in acute heart failure (AHF) trials. The aim of this study was to identify the risks and benefits of IV drugs in patients hospitalized with acute decompensated heart failure. Methods: The AHF global survey of standard treatment (ALARM-HF) reviewed in-hospital treatments in eight countries. The present study was a post hoc analysis of ALARM-HF data in which propensity scoring was used to identify groups of patients who differed by treatment but had the same multivariate distribution of covariates. Such propensity matching allowed estimations of the effect of specific treatments on the outcome of in-hospital mortality. Results: Unadjusted analysis showed a lower in-hospital mortality rate in AHF patients receiving "diuretics + vasodilators" (n = 1,805) compared to those receiving "diuretics alone" (n = 2,362) (7.6 vs. 14.2%, p < 0.0001). Propensity-based matching (n = 1,007 matched pairs) confirmed the lower mortality of AHF patients receiving diuretics + vasodilators: 7.8 versus 11.0% (p = 0.016). Unadjusted analysis showed a much greater in-hospital mortality rate in patients receiving IV inotropes (25.9%) compared to those who did not (5.2%) (p < 0.0001). Propensity-based matching (n = 954 pairs) confirmed that IV catecholamine use was associated with 1.5-fold increase for dopamine or dobutamine use and a >2.5-fold increase for norepinephrine or epinephrine use. Conclusions: In terms of in-hospital survival, a vasodilator in combination with a diuretic fared better than treatment with only a diuretic. Catecholamine inotropes should be used cautiously as it has been seen that they actually increase the risk for in-hospital mortality.002B27B; 002B27B01Insuffisance cardiaque; Court terme; Survie; Traitement; Homme; Alarme; Voie intraveineuse; Réanimation; Soin intensifPathologie de l'appareil circulatoire; CardiopathieHeart failure; Short term; Survival; Treatment; Human; Alarm; Intravenous administration; Resuscitation; Intensive careCardiovascular disease; Heart diseaseInsuficiencia cardíaca; Corto plazo; Sobrevivencia; Tratamiento; Hombre; Alarma; Vía intravenosa; Reanimación; Cuidado intensivoINIST-16256.35400019439083015011-0114691 001637 Hölder Continuity of Absolutely Continuous Spectral Measures for One-Frequency Schrödinger OperatorsArtur AvilaCNRS UMR 7586, Institut de Mathématiques de JussieuParisFRA1 aut.IMPA, Estrada Dona Castorina22460-320 Rio de JaneiroBRA1 aut.Svetlana JitomirskayaUniversity of CaliforniaIrvine, California 92697USA2 aut.11-01147822011PASCAL 11-0114782 INISTPascal:11-01147820012610010-3616Commun. math. phys.Communications in mathematical physicsDistribution functionMathematical physicsPhysique mathématiqueFonction répartition35J1047A10
We establish sharp results on the modulus of continuity of the distribution of the spectral measure for one-frequency Schrödinger operators with Diophantine frequencies in the region of absolutely continuous spectrum. More precisely, we establish 1/2-Hölder continuity near almost reducible energies (an essential support of absolutely continuous spectrum). For non-perturbatively small potentials (and for the almost Mathieu operator with subcritical coupling), our results apply for all energies.
0010-3616CMPHAYCommun. math. phys.3012Hölder Continuity of Absolutely Continuous Spectral Measures for One-Frequency Schrödinger OperatorsAVILA (Artur)JITOMIRSKAYA (Svetlana)CNRS UMR 7586, Institut de Mathématiques de JussieuParisFRA1 aut.IMPA, Estrada Dona Castorina22460-320 Rio de JaneiroBRA1 aut.University of CaliforniaIrvine, California 92697USA2 aut.563-5812011ENGINIST122603540001943959600900000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0114782PACommunications in mathematical physicsDEUWe establish sharp results on the modulus of continuity of the distribution of the spectral measure for one-frequency Schrödinger operators with Diophantine frequencies in the region of absolutely continuous spectrum. More precisely, we establish 1/2-Hölder continuity near almost reducible energies (an essential support of absolutely continuous spectrum). For non-perturbatively small potentials (and for the almost Mathieu operator with subcritical coupling), our results apply for all energies.001B00B90001A02E08001A02E17Physique mathématique01Mathematical physics01Fonction répartition17Distribution function17Función distribución1735J10INC7047A10INC71073OTOOTOPASCAL 11-0114782 INISTHölder Continuity of Absolutely Continuous Spectral Measures for One-Frequency Schrödinger OperatorsAVILA (Artur); JITOMIRSKAYA (Svetlana)CNRS UMR 7586, Institut de Mathématiques de Jussieu/Paris/France (1 aut.); IMPA, Estrada Dona Castorina/22460-320 Rio de Janeiro/Brésil (1 aut.); University of California/Irvine, California 92697/Etats-Unis (2 aut.)
Publication en série; Niveau analytique
Communications in mathematical physics; ISSN 0010-3616; Coden CMPHAY; Allemagne; Da. 2011; Vol. 301; No. 2; Pp. 563-581; Bibl. 3/4 p.AnglaisWe establish sharp results on the modulus of continuity of the distribution of the spectral measure for one-frequency Schrödinger operators with Diophantine frequencies in the region of absolutely continuous spectrum. More precisely, we establish 1/2-Hölder continuity near almost reducible energies (an essential support of absolutely continuous spectrum). For non-perturbatively small potentials (and for the almost Mathieu operator with subcritical coupling), our results apply for all energies.001B00B90; 001A02E08; 001A02E17Physique mathématique; Fonction répartition; 35J10; 47A10Mathematical physics; Distribution functionFunción distribuciónINIST-12260.35400019439596009011-0114782 001638 New estimates for the div, curl, grad operators and elliptic problems with L<sup>1</sup>-data in the half-spaceChérif AmroucheLaboratoire de Mathématiques Appliquées, Université de Pau et des Pays de l'Adour, IPRA, Avenue de l'Université64000 PauFRA1 aut.Huy Hoang NguyenDepartamento de Matematica, IMECC, Universidade Estadual de Campinas, Caixa Postal 6065Campinas, SP 13083-970BRA2 aut.11-01174882011PASCAL 11-0117488 INISTPascal:11-01174880012600893-9659Appl. math. lett.Applied mathematics lettersApplied mathematicsElliptic equationElliptic operatorPartial differential equationSobolev spaceMathématiques appliquéesOpérateur elliptiqueEquation dérivée partielleEquation elliptiqueEspace Sobolev46E35
In this Note, we study some properties of the div, curl, grad operators and elliptic problems in the half-space. We consider data in weighted Sobolev spaces and in L1.
0893-9659Appl. math. lett.245New estimates for the div, curl, grad operators and elliptic problems with L1-data in the half-spaceAMROUCHE (Chérif)HOANG NGUYEN (Huy)Laboratoire de Mathématiques Appliquées, Université de Pau et des Pays de l'Adour, IPRA, Avenue de l'Université64000 PauFRA1 aut.Departamento de Matematica, IMECC, Universidade Estadual de Campinas, Caixa Postal 6065Campinas, SP 13083-970BRA2 aut.697-7022011ENGINIST216473540001919627902200000© 2011 INIST-CNRS. All rights reserved.8 ref.11-0117488PAApplied mathematics lettersGBRIn this Note, we study some properties of the div, curl, grad operators and elliptic problems in the half-space. We consider data in weighted Sobolev spaces and in L1.001A02E16001A02I01Mathématiques appliquées01Applied mathematics01Matemáticas aplicadas01Opérateur elliptique17Elliptic operator17Operador elíptico17Equation dérivée partielle18Partial differential equation18Ecuación derivada parcial18Equation elliptique19Elliptic equation19Ecuación elíptica19Espace Sobolev20Sobolev space20Espacio Sobolev2046E35INC70073OTOOTOPASCAL 11-0117488 INISTNew estimates for the div, curl, grad operators and elliptic problems with L1-data in the half-spaceAMROUCHE (Chérif); HOANG NGUYEN (Huy)Laboratoire de Mathématiques Appliquées, Université de Pau et des Pays de l'Adour, IPRA, Avenue de l'Université/64000 Pau/France (1 aut.); Departamento de Matematica, IMECC, Universidade Estadual de Campinas, Caixa Postal 6065/Campinas, SP 13083-970/Brésil (2 aut.)
Publication en série; Niveau analytique
Applied mathematics letters; ISSN 0893-9659; Royaume-Uni; Da. 2011; Vol. 24; No. 5; Pp. 697-702; Bibl. 8 ref.AnglaisIn this Note, we study some properties of the div, curl, grad operators and elliptic problems in the half-space. We consider data in weighted Sobolev spaces and in L1.001A02E16; 001A02I01Mathématiques appliquées; Opérateur elliptique; Equation dérivée partielle; Equation elliptique; Espace Sobolev; 46E35Applied mathematics; Elliptic operator; Partial differential equation; Elliptic equation; Sobolev spaceMatemáticas aplicadas; Operador elíptico; Ecuación derivada parcial; Ecuación elíptica; Espacio SobolevINIST-21647.35400019196279022011-0117488 001639 Natural-orifice transluminal endoscopic surgery (NOTES) in Europe: summary of the working group reports of the Euro-NOTES meeting 2010A. MeiningDepartment of Medicine II, Technical University of MunichMunichDEU1 aut.H. FeussnerDepartment of Surgery and Surgical Oncology, Klinikum Rechts der Isar, Technical UniversityMunichDEU2 aut.P. SwainSt Mary's Hospital London, Department of Surgical Oncology and TechologyLondonGBR3 aut.G. Z. YangImperial College, Institute of Biomedical EngineeringLondonGBR4 aut.K. LehmannChirurgische Klinik und Hochschulambulanz I, Klinik für Allgemein-, Gefäss- und Thoraxchirurgie, Charité - Campus Benjamin FranklinBerlinDEU5 aut.R. ZorronUniversity Hospital Teresopolis, Department of SurgeryRio de JaneiroBRA6 aut.S. MeisnerBispebjerg HospitalCopenhagenDNK7 aut.J. PonskyDepartment of Surgery, University HospitalsOhio ClevelandUSA8 aut.H. MartinyAbt. Technische Hygiene, CharitéBerlinDEU9 aut.N. ReddyChairman & Chief of Gastroenterology, Asian Institute of GastroenterologyHyderabadIND10 aut.J. R. Armengol-MiroInstitut de Recerca Hospital, Universitari Vall d'HebronBarcelonaESP11 aut.P. FockensAcademic Medical Center,University of AmsterdamAmsterdamNLD12 aut.A. FingerhutCentre Hospitalier Intercommunal, Department of SurgeryPoissyFRA13 aut.G. CostamagnaPoliclinico A. GemelliRomeITA14 aut.11-01178842011PASCAL 11-0117884 INISTPascal:11-01178840012590013-726XEndoscopy : (Stuttg.)Endoscopy : (Stuttgart)EuropeNatural Orifice Transluminal Endoscopic SurgeryNuclear medicineRadiologyChirurgie NOTESEuropeMédecine nucléaireRadiologie
The fourth Euro-NOTES workshop took place in September 2010 and focused on enabling intensive scientific dialogue and interaction between participants to discuss the state of the practice and development of natural-orifice transluminal endoscopic surgery (NOTES) in Europe. Five working groups were formed, consisting of participants with varying scientific and medical backgrounds. Each group was assigned to an important topic: the correct strategy for dealing with bacterial contamination and related complications, the question of the ideal entry point and secure closure, interdisciplinary collaboration and indications, robotics and platforms, and matters related to training and education. This review summarizes consensus statements of the working groups to give an overview of what has been achieved so far and what might be relevant for research related to NOTES in the near future.
0013-726XENDCAMEndoscopy : (Stuttg.)432Natural-orifice transluminal endoscopic surgery (NOTES) in Europe: summary of the working group reports of the Euro-NOTES meeting 2010MEINING (A.)FEUSSNER (H.)SWAIN (P.)YANG (G. Z.)LEHMANN (K.)ZORRON (R.)MEISNER (S.)PONSKY (J.)MARTINY (H.)REDDY (N.)ARMENGOL-MIRO (J. R.)FOCKENS (P.)FINGERHUT (A.)COSTAMAGNA (G.)Department of Medicine II, Technical University of MunichMunichDEU1 aut.Department of Surgery and Surgical Oncology, Klinikum Rechts der Isar, Technical UniversityMunichDEU2 aut.St Mary's Hospital London, Department of Surgical Oncology and TechologyLondonGBR3 aut.Imperial College, Institute of Biomedical EngineeringLondonGBR4 aut.Chirurgische Klinik und Hochschulambulanz I, Klinik für Allgemein-, Gefäss- und Thoraxchirurgie, Charité - Campus Benjamin FranklinBerlinDEU5 aut.University Hospital Teresopolis, Department of SurgeryRio de JaneiroBRA6 aut.Bispebjerg HospitalCopenhagenDNK7 aut.Department of Surgery, University HospitalsOhio ClevelandUSA8 aut.Abt. Technische Hygiene, CharitéBerlinDEU9 aut.Chairman & Chief of Gastroenterology, Asian Institute of GastroenterologyHyderabadIND10 aut.Institut de Recerca Hospital, Universitari Vall d'HebronBarcelonaESP11 aut.Academic Medical Center,University of AmsterdamAmsterdamNLD12 aut.Centre Hospitalier Intercommunal, Department of SurgeryPoissyFRA13 aut.Policlinico A. GemelliRomeITA14 aut.140-1432011ENGINIST146053540001943498501000000© 2011 INIST-CNRS. All rights reserved.6 ref.11-0117884PAEndoscopy : (Stuttgart)DEUThe fourth Euro-NOTES workshop took place in September 2010 and focused on enabling intensive scientific dialogue and interaction between participants to discuss the state of the practice and development of natural-orifice transluminal endoscopic surgery (NOTES) in Europe. Five working groups were formed, consisting of participants with varying scientific and medical backgrounds. Each group was assigned to an important topic: the correct strategy for dealing with bacterial contamination and related complications, the question of the ideal entry point and secure closure, interdisciplinary collaboration and indications, robotics and platforms, and matters related to training and education. This review summarizes consensus statements of the working groups to give an overview of what has been achieved so far and what might be relevant for research related to NOTES in the near future.002B24Chirurgie NOTES04Natural Orifice Transluminal Endoscopic Surgery04Cirugía endoscópica transluminal a través de orificios naturales04EuropeNG07EuropeNG07EuropaNG07Médecine nucléaire08Nuclear medicine08Medicina nuclear08Radiologie09Radiology09Radiología09ChirurgieSurgeryCirugía073OTOOTOPASCAL 11-0117884 INISTNatural-orifice transluminal endoscopic surgery (NOTES) in Europe: summary of the working group reports of the Euro-NOTES meeting 2010MEINING (A.); FEUSSNER (H.); SWAIN (P.); YANG (G. Z.); LEHMANN (K.); ZORRON (R.); MEISNER (S.); PONSKY (J.); MARTINY (H.); REDDY (N.); ARMENGOL-MIRO (J. R.); FOCKENS (P.); FINGERHUT (A.); COSTAMAGNA (G.)Department of Medicine II, Technical University of Munich/Munich/Allemagne (1 aut.); Department of Surgery and Surgical Oncology, Klinikum Rechts der Isar, Technical University/Munich/Allemagne (2 aut.); St Mary's Hospital London, Department of Surgical Oncology and Techology/London/Royaume-Uni (3 aut.); Imperial College, Institute of Biomedical Engineering/London/Royaume-Uni (4 aut.); Chirurgische Klinik und Hochschulambulanz I, Klinik für Allgemein-, Gefäss- und Thoraxchirurgie, Charité - Campus Benjamin Franklin/Berlin/Allemagne (5 aut.); University Hospital Teresopolis, Department of Surgery/Rio de Janeiro/Brésil (6 aut.); Bispebjerg Hospital/Copenhagen/Danemark (7 aut.); Department of Surgery, University Hospitals/Ohio Cleveland/Etats-Unis (8 aut.); Abt. Technische Hygiene, Charité/Berlin/Allemagne (9 aut.); Chairman & Chief of Gastroenterology, Asian Institute of Gastroenterology/Hyderabad/Inde (10 aut.); Institut de Recerca Hospital, Universitari Vall d'Hebron/Barcelona/Espagne (11 aut.); Academic Medical Center,University of Amsterdam/Amsterdam/Pays-Bas (12 aut.); Centre Hospitalier Intercommunal, Department of Surgery/Poissy/France (13 aut.); Policlinico A. Gemelli/Rome/Italie (14 aut.)
Publication en série; Niveau analytique
Endoscopy : (Stuttgart); ISSN 0013-726X; Coden ENDCAM; Allemagne; Da. 2011; Vol. 43; No. 2; Pp. 140-143; Bibl. 6 ref.AnglaisThe fourth Euro-NOTES workshop took place in September 2010 and focused on enabling intensive scientific dialogue and interaction between participants to discuss the state of the practice and development of natural-orifice transluminal endoscopic surgery (NOTES) in Europe. Five working groups were formed, consisting of participants with varying scientific and medical backgrounds. Each group was assigned to an important topic: the correct strategy for dealing with bacterial contamination and related complications, the question of the ideal entry point and secure closure, interdisciplinary collaboration and indications, robotics and platforms, and matters related to training and education. This review summarizes consensus statements of the working groups to give an overview of what has been achieved so far and what might be relevant for research related to NOTES in the near future.002B24Chirurgie NOTES; Europe; Médecine nucléaire; RadiologieChirurgieNatural Orifice Transluminal Endoscopic Surgery; Europe; Nuclear medicine; RadiologySurgeryCirugía endoscópica transluminal a través de orificios naturales; Europa; Medicina nuclear; RadiologíaINIST-14605.35400019434985010011-0117884 001640 Smokers and non-smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA databaseA. NaranjoHospital de Gran Canaria Dr. Negrin, University of Las Palmas de Gran CanariaESP1 aut.S. TolozaHospital San Juan BautistaCatamarcaARG2 aut.I. Guimaraes Da SilveiraPontifícia Universidade Católica do Rio Grande do SulPorto AlegreBRA3 aut.J. LazovskisRiverside Professional CenterSydneyCAN4 aut.M. L. HetlandCopenhagen University Hospital at GlostrupDNK5 aut.H. HamoudAl-Azhar UniversityCairoEGY6 aut.T. PeetsEast-Tallinn Central HospitalTallinnEST7 aut.H. M KinenJyväskylä Central Hospital, Jyväskylä, and Tampere University HospitalTampereFIN8 aut.L. GossecParis Descartes University, Medicine Faculty; APHP, Rheumatology B Department, Cochin HospitalParisFRA9 aut.G. HerbornEvangelisches FachkrankenhausRatingenDEU10 aut.F. N. SkopouliEuroclinic HospitalAthensGRC11 aut.B. RojkovichPolyclinic of the Hospitaller Brothers of St. John of GodBudapestHUN12 aut.A. AggarwalSanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIND13 aut.P. MinnockOur Lady's HospiceDublinIRL14 aut.M. CazzatoDepartment of Internal Medicine, S. Chiara HospitalPisaITA15 aut.H. YamanakaInstitute of RheumatologyTokyoJPN16 aut.O. OyooKenyatta HospitalNairobiKEN17 aut.S. RexhepiRheumatology DepartmentPristineSRB18 aut.D. AndersonePauls Stradina Clinical University HospitalRigaLVA19 aut.A. BaranauskaiteKaunas University HospitalKaunasLTU20 aut.N. Hajjaj-HassouniAyachi Hospital Mohamed V Souissi UniversityRabatMAR21 aut.J. W. G. JacobsUniversity Medical Center UtrechtNLD22 aut.G. HaugebergSørlandet HospitalKristiansandNOR23 aut.S. SierakowskiMedical University in BialystokBialystokPOL24 aut.R. IonescuSpitalul Clinic Sf MariaBucharestROU25 aut.D. KarateewA. DimicD. HenrohnF. GogusH. BadshaE. ChoyM. BergmanT. Sokka11-01182232010PASCAL 11-0118223 INISTPascal:11-01182230012580392-856XClin. exp. rheumatol. : Testo stamp.)Clinical and experimental rheumatology : (Testo stampato)ChronicDatabaseRheumatoid arthritisRheumatologySmokerTobacco smokingPolyarthrite rhumatoïdeFumeurBase de donnéesTabagismeRhumatologieChronique
Objectives To analyse clinical severitylactivity of rheumatoid arthritis (RA) according to smoking status. Methods The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RF), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as "never smoked", "currently smoking" and "former smokers". Patient groups with different smoking status were compared for demographic and RA measures. Results Among the 7,307 patients with smoking data available, status as "never smoked," "current smoker" and "former smoker" were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32;1. 17-1.48, p<0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41;1.24-1.59, p<0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category). Conclusion RA patients who had ever smoked were more likely to have RF and nodules, but values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).
0392-856XClin. exp. rheumatol. : Testo stamp.)286Smokers and non-smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA databaseNARANJO (A.)TOLOZA (S.)GUIMARAES DA SILVEIRA (I.)LAZOVSKIS (J.)HETLAND (M. L.)HAMOUD (H.)PEETS (T.)MÄKINEN (H.)GOSSEC (L.)HERBORN (G.)SKOPOULI (F. N.)ROJKOVICH (B.)AGGARWAL (A.)MINNOCK (P.)CAZZATO (M.)YAMANAKA (H.)OYOO (O.)REXHEPI (S.)ANDERSONE (D.)BARANAUSKAITE (A.)HAJJAJ-HASSOUNI (N.)JACOBS (J. W. G.)HAUGEBERG (G.)SIERAKOWSKI (S.)IONESCU (R.)KARATEEW (D.)DIMIC (A.)HENROHN (D.)GOGUS (F.)BADSHA (H.)CHOY (E.)BERGMAN (M.)SOKKA (T.)Hospital de Gran Canaria Dr. Negrin, University of Las Palmas de Gran CanariaESP1 aut.Hospital San Juan BautistaCatamarcaARG2 aut.Pontifícia Universidade Católica do Rio Grande do SulPorto AlegreBRA3 aut.Riverside Professional CenterSydneyCAN4 aut.Copenhagen University Hospital at GlostrupDNK5 aut.Al-Azhar UniversityCairoEGY6 aut.East-Tallinn Central HospitalTallinnEST7 aut.Jyväskylä Central Hospital, Jyväskylä, and Tampere University HospitalTampereFIN8 aut.Paris Descartes University, Medicine Faculty; APHP, Rheumatology B Department, Cochin HospitalParisFRA9 aut.Evangelisches FachkrankenhausRatingenDEU10 aut.Euroclinic HospitalAthensGRC11 aut.Polyclinic of the Hospitaller Brothers of St. John of GodBudapestHUN12 aut.Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIND13 aut.Our Lady's HospiceDublinIRL14 aut.Department of Internal Medicine, S. Chiara HospitalPisaITA15 aut.Institute of RheumatologyTokyoJPN16 aut.Kenyatta HospitalNairobiKEN17 aut.Rheumatology DepartmentPristineSRB18 aut.Pauls Stradina Clinical University HospitalRigaLVA19 aut.Kaunas University HospitalKaunasLTU20 aut.Ayachi Hospital Mohamed V Souissi UniversityRabatMAR21 aut.University Medical Center UtrechtNLD22 aut.Sørlandet HospitalKristiansandNOR23 aut.Medical University in BialystokBialystokPOL24 aut.Spitalul Clinic Sf MariaBucharestROU25 aut.820-8272010ENGINIST209203540001943803600400000© 2011 INIST-CNRS. All rights reserved.47 ref.11-0118223PAClinical and experimental rheumatology : (Testo stampato)ITAObjectives To analyse clinical severitylactivity of rheumatoid arthritis (RA) according to smoking status. Methods The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RF), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as "never smoked", "currently smoking" and "former smokers". Patient groups with different smoking status were compared for demographic and RA measures. Results Among the 7,307 patients with smoking data available, status as "never smoked," "current smoker" and "former smoker" were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32;1. 17-1.48, p<0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41;1.24-1.59, p<0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category). Conclusion RA patients who had ever smoked were more likely to have RF and nodules, but values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).002B15D002B03EPolyarthrite rhumatoïde01Rheumatoid arthritis01Poliartritis reumatoidea01Fumeur07Smoker07Fumador07Base de données08Database08Base dato08Tabagisme09Tobacco smoking09Tabaquismo09Rhumatologie13Rheumatology13Reumatología13Chronique30Chronic30Crónico30Maladie autoimmune37Autoimmune disease37Enfermedad autoinmune37Rhumatisme inflammatoire38Inflammatory joint disease38Reumatismo inflamatorio38Pathologie du système ostéoarticulaire39Diseases of the osteoarticular system39Sistema osteoarticular patología39Immunopathologie40Immunopathology40Inmunopatología40073OTOOTOPASCAL 11-0118223 INISTSmokers and non-smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA databaseNARANJO (A.); TOLOZA (S.); GUIMARAES DA SILVEIRA (I.); LAZOVSKIS (J.); HETLAND (M. L.); HAMOUD (H.); PEETS (T.); MÄKINEN (H.); GOSSEC (L.); HERBORN (G.); SKOPOULI (F. N.); ROJKOVICH (B.); AGGARWAL (A.); MINNOCK (P.); CAZZATO (M.); YAMANAKA (H.); OYOO (O.); REXHEPI (S.); ANDERSONE (D.); BARANAUSKAITE (A.); HAJJAJ-HASSOUNI (N.); JACOBS (J. W. G.); HAUGEBERG (G.); SIERAKOWSKI (S.); IONESCU (R.); KARATEEW (D.); DIMIC (A.); HENROHN (D.); GOGUS (F.); BADSHA (H.); CHOY (E.); BERGMAN (M.); SOKKA (T.)Hospital de Gran Canaria Dr. Negrin, University of Las Palmas de Gran Canaria/Espagne (1 aut.); Hospital San Juan Bautista/Catamarca/Argentine (2 aut.); Pontifícia Universidade Católica do Rio Grande do Sul/Porto Alegre/Brésil (3 aut.); Riverside Professional Center/Sydney/Canada (4 aut.); Copenhagen University Hospital at Glostrup/Danemark (5 aut.); Al-Azhar University/Cairo/Egypte (6 aut.); East-Tallinn Central Hospital/Tallinn/Estonie (7 aut.); Jyväskylä Central Hospital, Jyväskylä, and Tampere University Hospital/Tampere/Finlande (8 aut.); Paris Descartes University, Medicine Faculty; APHP, Rheumatology B Department, Cochin Hospital/Paris/France (9 aut.); Evangelisches Fachkrankenhaus/Ratingen/Allemagne (10 aut.); Euroclinic Hospital/Athens/Grèce (11 aut.); Polyclinic of the Hospitaller Brothers of St. John of God/Budapest/Hongrie (12 aut.); Sanjay Gandhi Postgraduate Institute of Medical Sciences/Lucknow/Inde (13 aut.); Our Lady's Hospice/Dublin/Irlande (14 aut.); Department of Internal Medicine, S. Chiara Hospital/Pisa/Italie (15 aut.); Institute of Rheumatology/Tokyo/Japon (16 aut.); Kenyatta Hospital/Nairobi/Kenya (17 aut.); Rheumatology Department/Pristine/Serbie (18 aut.); Pauls Stradina Clinical University Hospital/Riga/Lettonie (19 aut.); Kaunas University Hospital/Kaunas/Lithuanie (20 aut.); Ayachi Hospital Mohamed V Souissi University/Rabat/Maroc (21 aut.); University Medical Center Utrecht/Pays-Bas (22 aut.); Sørlandet Hospital/Kristiansand/Norvège (23 aut.); Medical University in Bialystok/Bialystok/Pologne (24 aut.); Spitalul Clinic Sf Maria/Bucharest/Roumanie (25 aut.)
Publication en série; Niveau analytique
Clinical and experimental rheumatology : (Testo stampato); ISSN 0392-856X; Italie; Da. 2010; Vol. 28; No. 6; Pp. 820-827; Bibl. 47 ref.AnglaisObjectives To analyse clinical severitylactivity of rheumatoid arthritis (RA) according to smoking status. Methods The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RF), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as "never smoked", "currently smoking" and "former smokers". Patient groups with different smoking status were compared for demographic and RA measures. Results Among the 7,307 patients with smoking data available, status as "never smoked," "current smoker" and "former smoker" were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32;1. 17-1.48, p<0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41;1.24-1.59, p<0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category). Conclusion RA patients who had ever smoked were more likely to have RF and nodules, but values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).002B15D; 002B03EPolyarthrite rhumatoïde; Fumeur; Base de données; Tabagisme; Rhumatologie; ChroniqueMaladie autoimmune; Rhumatisme inflammatoire; Pathologie du système ostéoarticulaire; ImmunopathologieRheumatoid arthritis; Smoker; Database; Tobacco smoking; Rheumatology; ChronicAutoimmune disease; Inflammatory joint disease; Diseases of the osteoarticular system; ImmunopathologyPoliartritis reumatoidea; Fumador; Base dato; Tabaquismo; Reumatología; CrónicoINIST-20920.35400019438036004011-0118223 001641 Extender composition, osmolality and cryoprotectant effects on the motility of sperm in the Brazilian endangered species Brycon opalinus (Characiformes)Laura H. OrfaoDept Animal Sciences, Federal University of Lavras, UFLALavras, MG 37200-000BRA1 aut.2 aut.5 aut.Ariane F. NascimentoDept Animal Sciences, Federal University of Lavras, UFLALavras, MG 37200-000BRA1 aut.2 aut.5 aut.Fabio M. CorreaDept Exact Sciences, Federal University of Lavras, UFLALavras, MG 37200-000BRA3 aut.Jacky CossonUMR 7009 CNRS, Université Pierre et Marie Curie, Marine Station06230 Villefranche sur merFRA4 aut.University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses38925 VodnanyCZE4 aut.Ana T. M. ViveirosDept Animal Sciences, Federal University of Lavras, UFLALavras, MG 37200-000BRA1 aut.2 aut.5 aut.11-01183492011PASCAL 11-0118349 INISTPascal:11-01183490012570044-8486Aquaculture : (Amst.)Aquaculture : (Amsterdam)AquacultureBrazilCompositionCryoprotective agentEndangered speciesMotilityQualitySpermatozoaCompositionCryoprotecteurMotilitéSpermatozoïdeBrésilEspèce menacéeQualitéAquicultureBrycon
Sperm preservation is an important tool for conservation of endangered fish species, such as the Brycon opalinus (Characiformes). An optimum medium should prevent the initiation of sperm motility during storage. The aim of this paper was to study the effects of extender composition, osmolality and cryoprotectant agent (CPA) on the motility of B. opalinus sperm after a 30-min equilibration time. Eight media were prepared by switching extender compositions (NaCl or glucose) and osmolalities (245, 285, 325 or 365 mOsm/kg). These media were then divided in three aliquots and combined with two CPAs (dimethyl sulfoxide, DMSO, or methylglycol, MG) at 1.4 M; the third aliquot remained without CPA (control). After dilution, all samples were observed under light microscope to confirm whether all extender-CPA combinations actually prevented the initiation of sperm motility. Then, sperm motility was triggered in NaCl 92 mOsm/kg as activating agent after 0- and 30-min equilibration time at 4 °C and the percentage of motile sperm and duration of motility were determined. All combinations of glucose or NaCl media at high osmolalities (325 and 365 mOsm/kg), completely suppressed the initiation of sperm motility. Low extender osmolalities (245 mOsm/kg), however, did not prevent the initiation of sperm motility and more than 50% of sperm diluted in all combinations of glucose media, NaCl-control and in NaCl-DMSO were motile. When motility was triggered after both 0- and 30-min equilibration times, more than 77% motile sperm were observed in all combinations of NaCl and glucose media, except for glucose 245-DMSO and glucose 285-DMSO. The duration of motility in sperm diluted in all media was above 40 s, except for glucose 245-DMSO. Based on these findings, we can conclude that the initiation of sperm motility is triggered by low osmolality rather than the ionic composition of the surrounding medium in B. opalinus. Glucose or NaCl solutions at high osmolalities combined with either DMSO or MG prevent the initiation of sperm motility during storage. Sperm diluted in these media yields motility upon activation above 77% and that should last long enough to fertilize oocytes. These media are recommended as freezing media for future essays in cryopreservation of B. opalinus sperm. .
0044-8486AQCLALAquaculture : (Amst.)3111-4Extender composition, osmolality and cryoprotectant effects on the motility of sperm in the Brazilian endangered species Brycon opalinus (Characiformes)ORFAO (Laura H.)NASCIMENTO (Ariane F.)CORREA (Fabio M.)COSSON (Jacky)VIVEIROS (Ana T. M.)Dept Animal Sciences, Federal University of Lavras, UFLALavras, MG 37200-000BRA1 aut.2 aut.5 aut.Dept Exact Sciences, Federal University of Lavras, UFLALavras, MG 37200-000BRA3 aut.UMR 7009 CNRS, Université Pierre et Marie Curie, Marine Station06230 Villefranche sur merFRA4 aut.University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses38925 VodnanyCZE4 aut.241-2472011ENGINIST159643540001943581803400000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0118349PAAquaculture : (Amsterdam)NLDSperm preservation is an important tool for conservation of endangered fish species, such as the Brycon opalinus (Characiformes). An optimum medium should prevent the initiation of sperm motility during storage. The aim of this paper was to study the effects of extender composition, osmolality and cryoprotectant agent (CPA) on the motility of B. opalinus sperm after a 30-min equilibration time. Eight media were prepared by switching extender compositions (NaCl or glucose) and osmolalities (245, 285, 325 or 365 mOsm/kg). These media were then divided in three aliquots and combined with two CPAs (dimethyl sulfoxide, DMSO, or methylglycol, MG) at 1.4 M; the third aliquot remained without CPA (control). After dilution, all samples were observed under light microscope to confirm whether all extender-CPA combinations actually prevented the initiation of sperm motility. Then, sperm motility was triggered in NaCl 92 mOsm/kg as activating agent after 0- and 30-min equilibration time at 4 °C and the percentage of motile sperm and duration of motility were determined. All combinations of glucose or NaCl media at high osmolalities (325 and 365 mOsm/kg), completely suppressed the initiation of sperm motility. Low extender osmolalities (245 mOsm/kg), however, did not prevent the initiation of sperm motility and more than 50% of sperm diluted in all combinations of glucose media, NaCl-control and in NaCl-DMSO were motile. When motility was triggered after both 0- and 30-min equilibration times, more than 77% motile sperm were observed in all combinations of NaCl and glucose media, except for glucose 245-DMSO and glucose 285-DMSO. The duration of motility in sperm diluted in all media was above 40 s, except for glucose 245-DMSO. Based on these findings, we can conclude that the initiation of sperm motility is triggered by low osmolality rather than the ionic composition of the surrounding medium in B. opalinus. Glucose or NaCl solutions at high osmolalities combined with either DMSO or MG prevent the initiation of sperm motility during storage. Sperm diluted in these media yields motility upon activation above 77% and that should last long enough to fertilize oocytes. These media are recommended as freezing media for future essays in cryopreservation of B. opalinus sperm. .002A36B01002A15BComposition01Composition01Composicion01Cryoprotecteur02Cryoprotective agent02Crioprotector02Motilité03Motility03Motilidad03Spermatozoïde04Spermatozoa04Espermatozoide04BrésilNG05BrazilNG05BrasilNG05Espèce menacée06Endangered species06Especie amenazada06Qualité07Quality07Calidad07Aquiculture08Aquaculture08Acuicultura08BryconINC64Amérique du SudNGSouth AmericaNGAmerica del surNGAmériqueNGAmericaNGAmericaNGTeleosteiNS29TeleosteiNS29TeleosteiNS29OsteichthyesNSOsteichthyesNSOsteichthyesNSPiscesNSPiscesNSPiscesNSVertebrataNSVertebrataNSVertebrataNSCharacidaeINC70073OTOOTOPASCAL 11-0118349 INISTExtender composition, osmolality and cryoprotectant effects on the motility of sperm in the Brazilian endangered species Brycon opalinus (Characiformes)ORFAO (Laura H.); NASCIMENTO (Ariane F.); CORREA (Fabio M.); COSSON (Jacky); VIVEIROS (Ana T. M.)Dept Animal Sciences, Federal University of Lavras, UFLA/Lavras, MG 37200-000/Brésil (1 aut., 2 aut., 5 aut.); Dept Exact Sciences, Federal University of Lavras, UFLA/Lavras, MG 37200-000/Brésil (3 aut.); UMR 7009 CNRS, Université Pierre et Marie Curie, Marine Station/06230 Villefranche sur mer/France (4 aut.); University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses/38925 Vodnany/Tchèque, République (4 aut.)
Publication en série; Niveau analytique
Aquaculture : (Amsterdam); ISSN 0044-8486; Coden AQCLAL; Pays-Bas; Da. 2011; Vol. 311; No. 1-4; Pp. 241-247; Bibl. 3/4 p.AnglaisSperm preservation is an important tool for conservation of endangered fish species, such as the Brycon opalinus (Characiformes). An optimum medium should prevent the initiation of sperm motility during storage. The aim of this paper was to study the effects of extender composition, osmolality and cryoprotectant agent (CPA) on the motility of B. opalinus sperm after a 30-min equilibration time. Eight media were prepared by switching extender compositions (NaCl or glucose) and osmolalities (245, 285, 325 or 365 mOsm/kg). These media were then divided in three aliquots and combined with two CPAs (dimethyl sulfoxide, DMSO, or methylglycol, MG) at 1.4 M; the third aliquot remained without CPA (control). After dilution, all samples were observed under light microscope to confirm whether all extender-CPA combinations actually prevented the initiation of sperm motility. Then, sperm motility was triggered in NaCl 92 mOsm/kg as activating agent after 0- and 30-min equilibration time at 4 °C and the percentage of motile sperm and duration of motility were determined. All combinations of glucose or NaCl media at high osmolalities (325 and 365 mOsm/kg), completely suppressed the initiation of sperm motility. Low extender osmolalities (245 mOsm/kg), however, did not prevent the initiation of sperm motility and more than 50% of sperm diluted in all combinations of glucose media, NaCl-control and in NaCl-DMSO were motile. When motility was triggered after both 0- and 30-min equilibration times, more than 77% motile sperm were observed in all combinations of NaCl and glucose media, except for glucose 245-DMSO and glucose 285-DMSO. The duration of motility in sperm diluted in all media was above 40 s, except for glucose 245-DMSO. Based on these findings, we can conclude that the initiation of sperm motility is triggered by low osmolality rather than the ionic composition of the surrounding medium in B. opalinus. Glucose or NaCl solutions at high osmolalities combined with either DMSO or MG prevent the initiation of sperm motility during storage. Sperm diluted in these media yields motility upon activation above 77% and that should last long enough to fertilize oocytes. These media are recommended as freezing media for future essays in cryopreservation of B. opalinus sperm. .002A36B01; 002A15BComposition; Cryoprotecteur; Motilité; Spermatozoïde; Brésil; Espèce menacée; Qualité; Aquiculture; BryconAmérique du Sud; Amérique; Teleostei; Osteichthyes; Pisces; Vertebrata; CharacidaeComposition; Cryoprotective agent; Motility; Spermatozoa; Brazil; Endangered species; Quality; AquacultureSouth America; America; Teleostei; Osteichthyes; Pisces; VertebrataComposicion; Crioprotector; Motilidad; Espermatozoide; Brasil; Especie amenazada; Calidad; AcuiculturaINIST-15964.35400019435818034011-0118349 001642 Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes Undergoing Coronary Artery Bypass Surgery: Results From the PLATO (Platelet Inhibition and Patient Outcomes) TrialClaes HeldUppsala Clinical Research Center and Department of Medical Sciences, Uppsala UniversityUppsalaSWE1 aut.2 aut.10 aut.17 aut.Nils AsenbladUppsala Clinical Research Center and Department of Medical Sciences, Uppsala UniversityUppsalaSWE1 aut.2 aut.10 aut.17 aut.Jean Pierre BassandUniversity of BesanconBesanconFRA3 aut.Richard C. BeckerDuke Clinical Research InstituteDurham, North CarolinaUSA4 aut.7 aut.11 aut.Christopher P. CannonTIMI Study Group, Brigham and Women's HospitalBoston, MassachusettsUSA5 aut.13 aut.Marc J. ClaeysUniversity Hospital AntwerpEdegemBEL6 aut.Robert A. HarringtonDuke Clinical Research InstituteDurham, North CarolinaUSA4 aut.7 aut.11 aut.Jay HorrowAstraZeneca Research and DevelopmentWilmington, DelawareUSA8 aut.16 aut.Steen HustedÅrhus University HospitalÅrhusDNK9 aut.Stefan K. JamesUppsala Clinical Research Center and Department of Medical Sciences, Uppsala UniversityUppsalaSWE1 aut.2 aut.10 aut.17 aut.Kenneth W. MahaffeyDuke Clinical Research InstituteDurham, North CarolinaUSA4 aut.7 aut.11 aut.José C. NicolauUniversity of São Paolo Medical SchoolSão PaoloBRA12 aut.Benjamin M. SciricaTIMI Study Group, Brigham and Women's HospitalBoston, MassachusettsUSA5 aut.13 aut.Robert F. StoreyUniversity of SheffieldSheffieldGBR14 aut.Marius VintilaCarol Davila University of Medicine BucharestBucharestROU15 aut.Joseph YcasAstraZeneca Research and DevelopmentWilmington, DelawareUSA8 aut.16 aut.Lars WallentinUppsala Clinical Research Center and Department of Medical Sciences, Uppsala UniversityUppsalaSWE1 aut.2 aut.10 aut.17 aut.11-01193972011PASCAL 11-0119397 INISTPascal:11-01193970012560735-1097J. Am. Coll. Cardiol.Journal of the American College of CardiologyAcute coronary syndromeAntiplatelet agentCardiologyCirculatory systemClopidogrelComparative studyCoronary artery bypassCoronary heart diseaseHumanInhibitionPatientPlateletPrognosisResultTicagrelorCardiopathie coronaireTicagrélorEtude comparativeClopidogrelInhibiteur thromboagrégationHommeMaladeRésultatThrombocyteInhibitionPronosticAppareil circulatoireCardiologieSyndrome coronaire aiguPontage coronarien
Objectives The purpose of this study is to evaluate the efficacy and safety of ticagrelor and clopidogrel in patients with acute coronary syndrome undergoing coronary artery bypass graft surgery (CABG), as a post-randomization strategy. Background Ticagrelor is a novel, reversibly binding, oral, direct-acting P2Y12-receptor antagonist. In the PLATO (Platelet Inhibition and Patient Outcomes) trial, which randomized 18,624 patients with acute coronary syndromes, ticagrelor compared with clopidogrel significantly reduced the risk of the primary composite end point of cardiovascular (CV) death, myocardial infarction, or stroke (hazard ratio [HR]: 0.84; 95% confidence interval [CI]: 0.77 to 0.92; p < 0.001). This report investigated the outcomes of patients treated with CABG during the trial. Methods In total, 1,899 patients underwent CABG post-randomization. The protocol recommended ticagrelor/placebo to be withheld for 24 to 72 h and clopidogrel/placebo for 5 days preoperatively. In all, 1,261 patients underwent CABG and were receiving study drug treatment <7 days before surgery. The statistical analysis was based on events occurring from the CABG procedure until the end of the study, excluding 3 patients with CABG after study end. Results In the 1,261 patient cohort, the relative reduction of primary composite end point at 12 months (10.6% [66 of 629] with ticagrelor versus 13.1% [79 of 629] with clopidogrel; HR: 0.84; 95% CI: 0.60 to 1.16; p = 0.29) was consistent with the results of the whole trial. Total mortality was reduced from 9.7% (58 of 629) to 4.7% (29 of 629; HR: 0.49; 95% CI: 0.32 to 0.77; p < 0.01), CV death from 7.9% (47 of 629) to 4.1% (25 of 629; HR: 0.52; 95% CI: 0.32 to 0.85; p < 0.01), and non-CV death numerically from 2.0% to 0.7% (p = 0.07). There was no significant difference in CABG-related major bleeding between the randomized treatments. Conclusions In the subgroup of patients undergoing CABG within 7 days after the last study drug intake, ticagrelor compared with clopidogrel was associated with a substantial reduction in total and CV mortality without excess risk of CABG-related bleeding.
0735-1097JACCDIJ. Am. Coll. Cardiol.576Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes Undergoing Coronary Artery Bypass Surgery: Results From the PLATO (Platelet Inhibition and Patient Outcomes) TrialHELD (Claes)ASENBLAD (Nils)PIERRE BASSAND (Jean)BECKER (Richard C.)CANNON (Christopher P.)CLAEYS (Marc J.)HARRINGTON (Robert A.)HORROW (Jay)HUSTED (Steen)JAMES (Stefan K.)MAHAFFEY (Kenneth W.)NICOLAU (José C.)SCIRICA (Benjamin M.)STOREY (Robert F.)VINTILA (Marius)YCAS (Joseph)WALLENTIN (Lars)Uppsala Clinical Research Center and Department of Medical Sciences, Uppsala UniversityUppsalaSWE1 aut.2 aut.10 aut.17 aut.University of BesanconBesanconFRA3 aut.Duke Clinical Research InstituteDurham, North CarolinaUSA4 aut.7 aut.11 aut.TIMI Study Group, Brigham and Women's HospitalBoston, MassachusettsUSA5 aut.13 aut.University Hospital AntwerpEdegemBEL6 aut.AstraZeneca Research and DevelopmentWilmington, DelawareUSA8 aut.16 aut.Århus University HospitalÅrhusDNK9 aut.University of São Paolo Medical SchoolSão PaoloBRA12 aut.University of SheffieldSheffieldGBR14 aut.Carol Davila University of Medicine BucharestBucharestROU15 aut.672-6842011ENGINIST200983540001919722800500000© 2011 INIST-CNRS. All rights reserved.22 ref.11-0119397PAJournal of the American College of CardiologyUSAObjectives The purpose of this study is to evaluate the efficacy and safety of ticagrelor and clopidogrel in patients with acute coronary syndrome undergoing coronary artery bypass graft surgery (CABG), as a post-randomization strategy. Background Ticagrelor is a novel, reversibly binding, oral, direct-acting P2Y12-receptor antagonist. In the PLATO (Platelet Inhibition and Patient Outcomes) trial, which randomized 18,624 patients with acute coronary syndromes, ticagrelor compared with clopidogrel significantly reduced the risk of the primary composite end point of cardiovascular (CV) death, myocardial infarction, or stroke (hazard ratio [HR]: 0.84; 95% confidence interval [CI]: 0.77 to 0.92; p < 0.001). This report investigated the outcomes of patients treated with CABG during the trial. Methods In total, 1,899 patients underwent CABG post-randomization. The protocol recommended ticagrelor/placebo to be withheld for 24 to 72 h and clopidogrel/placebo for 5 days preoperatively. In all, 1,261 patients underwent CABG and were receiving study drug treatment <7 days before surgery. The statistical analysis was based on events occurring from the CABG procedure until the end of the study, excluding 3 patients with CABG after study end. Results In the 1,261 patient cohort, the relative reduction of primary composite end point at 12 months (10.6% [66 of 629] with ticagrelor versus 13.1% [79 of 629] with clopidogrel; HR: 0.84; 95% CI: 0.60 to 1.16; p = 0.29) was consistent with the results of the whole trial. Total mortality was reduced from 9.7% (58 of 629) to 4.7% (29 of 629; HR: 0.49; 95% CI: 0.32 to 0.77; p < 0.01), CV death from 7.9% (47 of 629) to 4.1% (25 of 629; HR: 0.52; 95% CI: 0.32 to 0.85; p < 0.01), and non-CV death numerically from 2.0% to 0.7% (p = 0.07). There was no significant difference in CABG-related major bleeding between the randomized treatments. Conclusions In the subgroup of patients undergoing CABG within 7 days after the last study drug intake, ticagrelor compared with clopidogrel was associated with a substantial reduction in total and CV mortality without excess risk of CABG-related bleeding.002B12A03002B25E002B12A05Cardiopathie coronaire01Coronary heart disease01Cardiopatía coronaria01TicagrélorFR09TicagrelorFR09TicagrelorFR09Etude comparative10Comparative study10Estudio comparativo10ClopidogrelNKFR11ClopidogrelNKFR11ClopidogrelNKFR11Inhibiteur thromboagrégation12Antiplatelet agent12Inhibidor tromboagregación12Homme13Human13Hombre13Malade14Patient14Enfermo14Résultat15Result15Resultado15Thrombocyte16Platelet16Trombocito16Inhibition17Inhibition17Inhibición17Pronostic18Prognosis18Pronóstico18Appareil circulatoire19Circulatory system19Aparato circulatorio19Cardiologie20Cardiology20Cardiología20Syndrome coronaire aiguCD96Acute coronary syndromeCD96Síndrome coronario agudoCD96Pontage coronarienCD97Coronary artery bypassCD97Puente aorto coronarioCD97Pathologie de l'appareil circulatoire37Cardiovascular disease37Aparato circulatorio patología37Pathologie du myocarde38Myocardial disease38Miocardio patología38Chirurgie cardiaqueINC86080OTOOTOPASCAL 11-0119397 INISTTicagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes Undergoing Coronary Artery Bypass Surgery: Results From the PLATO (Platelet Inhibition and Patient Outcomes) TrialHELD (Claes); ASENBLAD (Nils); PIERRE BASSAND (Jean); BECKER (Richard C.); CANNON (Christopher P.); CLAEYS (Marc J.); HARRINGTON (Robert A.); HORROW (Jay); HUSTED (Steen); JAMES (Stefan K.); MAHAFFEY (Kenneth W.); NICOLAU (José C.); SCIRICA (Benjamin M.); STOREY (Robert F.); VINTILA (Marius); YCAS (Joseph); WALLENTIN (Lars)Uppsala Clinical Research Center and Department of Medical Sciences, Uppsala University/Uppsala/Suède (1 aut., 2 aut., 10 aut., 17 aut.); University of Besancon/Besancon/France (3 aut.); Duke Clinical Research Institute/Durham, North Carolina/Etats-Unis (4 aut., 7 aut., 11 aut.); TIMI Study Group, Brigham and Women's Hospital/Boston, Massachusetts/Etats-Unis (5 aut., 13 aut.); University Hospital Antwerp/Edegem/Belgique (6 aut.); AstraZeneca Research and Development/Wilmington, Delaware/Etats-Unis (8 aut., 16 aut.); Århus University Hospital/Århus/Danemark (9 aut.); University of São Paolo Medical School/São Paolo/Brésil (12 aut.); University of Sheffield/Sheffield/Royaume-Uni (14 aut.); Carol Davila University of Medicine Bucharest/Bucharest/Roumanie (15 aut.)
Publication en série; Niveau analytique
Journal of the American College of Cardiology; ISSN 0735-1097; Coden JACCDI; Etats-Unis; Da. 2011; Vol. 57; No. 6; Pp. 672-684; Bibl. 22 ref.AnglaisObjectives The purpose of this study is to evaluate the efficacy and safety of ticagrelor and clopidogrel in patients with acute coronary syndrome undergoing coronary artery bypass graft surgery (CABG), as a post-randomization strategy. Background Ticagrelor is a novel, reversibly binding, oral, direct-acting P2Y12-receptor antagonist. In the PLATO (Platelet Inhibition and Patient Outcomes) trial, which randomized 18,624 patients with acute coronary syndromes, ticagrelor compared with clopidogrel significantly reduced the risk of the primary composite end point of cardiovascular (CV) death, myocardial infarction, or stroke (hazard ratio [HR]: 0.84; 95% confidence interval [CI]: 0.77 to 0.92; p < 0.001). This report investigated the outcomes of patients treated with CABG during the trial. Methods In total, 1,899 patients underwent CABG post-randomization. The protocol recommended ticagrelor/placebo to be withheld for 24 to 72 h and clopidogrel/placebo for 5 days preoperatively. In all, 1,261 patients underwent CABG and were receiving study drug treatment <7 days before surgery. The statistical analysis was based on events occurring from the CABG procedure until the end of the study, excluding 3 patients with CABG after study end. Results In the 1,261 patient cohort, the relative reduction of primary composite end point at 12 months (10.6% [66 of 629] with ticagrelor versus 13.1% [79 of 629] with clopidogrel; HR: 0.84; 95% CI: 0.60 to 1.16; p = 0.29) was consistent with the results of the whole trial. Total mortality was reduced from 9.7% (58 of 629) to 4.7% (29 of 629; HR: 0.49; 95% CI: 0.32 to 0.77; p < 0.01), CV death from 7.9% (47 of 629) to 4.1% (25 of 629; HR: 0.52; 95% CI: 0.32 to 0.85; p < 0.01), and non-CV death numerically from 2.0% to 0.7% (p = 0.07). There was no significant difference in CABG-related major bleeding between the randomized treatments. Conclusions In the subgroup of patients undergoing CABG within 7 days after the last study drug intake, ticagrelor compared with clopidogrel was associated with a substantial reduction in total and CV mortality without excess risk of CABG-related bleeding.002B12A03; 002B25E; 002B12A05Cardiopathie coronaire; Ticagrélor; Etude comparative; Clopidogrel; Inhibiteur thromboagrégation; Homme; Malade; Résultat; Thrombocyte; Inhibition; Pronostic; Appareil circulatoire; Cardiologie; Syndrome coronaire aigu; Pontage coronarienPathologie de l'appareil circulatoire; Pathologie du myocarde; Chirurgie cardiaqueCoronary heart disease; Ticagrelor; Comparative study; Clopidogrel; Antiplatelet agent; Human; Patient; Result; Platelet; Inhibition; Prognosis; Circulatory system; Cardiology; Acute coronary syndrome; Coronary artery bypassCardiovascular disease; Myocardial diseaseCardiopatía coronaria; Ticagrelor; Estudio comparativo; Clopidogrel; Inhibidor tromboagregación; Hombre; Enfermo; Resultado; Trombocito; Inhibición; Pronóstico; Aparato circulatorio; Cardiología; Síndrome coronario agudo; Puente aorto coronarioINIST-20098.35400019197228005011-0119397 001643 T Regulatory Lymphocytes Prevent Angiotensin II-Induced Hypertension and Vascular InjuryTlili BarhoumiLady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill UniversityMontreal, QuebecCAN1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.Université d'Avignon et des Pays de VaucluseAvignonFRA1 aut.5 aut.Daniel A. KasalLady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill UniversityMontreal, QuebecCAN1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.State University of Rio de JaneiroRio de JaneiroBRA2 aut.6 aut.Melissa W. LiLady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill UniversityMontreal, QuebecCAN1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.Layla ShbatLady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill UniversityMontreal, QuebecCAN1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.Pascal LaurantUniversité d'Avignon et des Pays de VaucluseAvignonFRA1 aut.5 aut.Mario F. NevesState University of Rio de JaneiroRio de JaneiroBRA2 aut.6 aut.Pierre ParadisLady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill UniversityMontreal, QuebecCAN1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.Ernesto L. SchiffrinLady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill UniversityMontreal, QuebecCAN1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill UniversityMontreal, QuebecCAN8 aut.11-01195412011PASCAL 11-0119541 INISTPascal:11-01195410012550194-911XHypertension : (Dallas Tex., 1979)Hypertension : (Dallas, Tex. 1979)Angiotensin IIArterial pressureBlood pressureCardiovascular diseaseCytokineHypertensionImmunityInflammationT-LymphocyteVascular remodelingHypertension artériellePathologie de l'appareil circulatoireLymphocyte TAngiotensine IIImmunitéInflammationCytokinePression artériellePression sanguineRemodelage vasculaire
Angiotensin (Ang) II induces hypertension by mechanisms mediated in part by adaptive immunity and T effector lymphocytes. T regulatory lymphocytes (Tregs) suppress T effector lymphocytes. We questioned whether Treg adoptive transfer would blunt Ang II-induced hypertension and vascular injury. Ten- to 12-week-old male C57BL/6 mice were injected IV with 3 × 105 Treg (CD4+CD25+) or T effector (CD4+CD25-) cells, 3 times at 2-week intervals, and then infused or not with Ang II (1 μg/kg per minute, SC) for 14 days. Ang II increased systolic blood pressure by 43 mm Hg (P<0.05), NADPH oxidase activity 1.5-fold in aorta and 1.8-fold in the heart (P<0.05), impaired acetylcholine vasodilatory responses by 70% compared with control (P<0.05), and increased vascular stiffness (P<0.001), mesenteric artery vascular cell adhesion molecule expression (2-fold; P<0.05), and aortic macrophage and T-cell infiltration (P<0.001). All of the above were prevented by Treg but not T effector adoptive transfer. Ang II caused a 43% decrease in Foxp3+ cells in the renal cortex, whereas Treg adoptive transfer increased Foxp3+ cells 2-fold compared with control. Thus, Tregs suppress Ang II-mediated vascular injury in part through anti-inflammatory actions. Immune mechanisms modulate Ang II-induced blood pressure elevation, vascular oxidative stress, inflammation, and endothelial dysfunction.
0194-911XHPRTDNHypertension : (Dallas Tex., 1979)573T Regulatory Lymphocytes Prevent Angiotensin II-Induced Hypertension and Vascular InjuryBARHOUMI (Tlili)KASAL (Daniel A.)LI (Melissa W.)SHBAT (Layla)LAURANT (Pascal)NEVES (Mario F.)PARADIS (Pierre)SCHIFFRIN (Ernesto L.)Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill UniversityMontreal, QuebecCAN1 aut.2 aut.3 aut.4 aut.7 aut.8 aut.Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill UniversityMontreal, QuebecCAN8 aut.Université d'Avignon et des Pays de VaucluseAvignonFRA1 aut.5 aut.State University of Rio de JaneiroRio de JaneiroBRA2 aut.6 aut.469-4762011ENGINIST180593540001919727702000000© 2011 INIST-CNRS. All rights reserved.32 ref.11-0119541PAHypertension : (Dallas, Tex. 1979)USAAngiotensin (Ang) II induces hypertension by mechanisms mediated in part by adaptive immunity and T effector lymphocytes. T regulatory lymphocytes (Tregs) suppress T effector lymphocytes. We questioned whether Treg adoptive transfer would blunt Ang II-induced hypertension and vascular injury. Ten- to 12-week-old male C57BL/6 mice were injected IV with 3 × 105 Treg (CD4+CD25+) or T effector (CD4+CD25-) cells, 3 times at 2-week intervals, and then infused or not with Ang II (1 μg/kg per minute, SC) for 14 days. Ang II increased systolic blood pressure by 43 mm Hg (P<0.05), NADPH oxidase activity 1.5-fold in aorta and 1.8-fold in the heart (P<0.05), impaired acetylcholine vasodilatory responses by 70% compared with control (P<0.05), and increased vascular stiffness (P<0.001), mesenteric artery vascular cell adhesion molecule expression (2-fold; P<0.05), and aortic macrophage and T-cell infiltration (P<0.001). All of the above were prevented by Treg but not T effector adoptive transfer. Ang II caused a 43% decrease in Foxp3+ cells in the renal cortex, whereas Treg adoptive transfer increased Foxp3+ cells 2-fold compared with control. Thus, Tregs suppress Ang II-mediated vascular injury in part through anti-inflammatory actions. Immune mechanisms modulate Ang II-induced blood pressure elevation, vascular oxidative stress, inflammation, and endothelial dysfunction.002B12B05002B12B05BHypertension artérielle01Hypertension01Hipertensión arterial01Pathologie de l'appareil circulatoire02Cardiovascular disease02Aparato circulatorio patología02Lymphocyte T09T-Lymphocyte09Linfocito T09Angiotensine IIFR10Angiotensin IIFR10Angiotensina IIFR10Immunité11Immunity11Inmunidad11Inflammation12Inflammation12Inflamación12Cytokine13Cytokine13Citoquina13Pression artérielle14Arterial pressure14Presión arterial14Pression sanguine15Blood pressure15Presión sanguínea15Remodelage vasculaire16Vascular remodeling16Remodelado vascular16Hormone peptide37Peptide hormone37Hormona péptido37Octapeptide38Octapeptide38Octapéptido38080OTOOTOPASCAL 11-0119541 INISTT Regulatory Lymphocytes Prevent Angiotensin II-Induced Hypertension and Vascular InjuryBARHOUMI (Tlili); KASAL (Daniel A.); LI (Melissa W.); SHBAT (Layla); LAURANT (Pascal); NEVES (Mario F.); PARADIS (Pierre); SCHIFFRIN (Ernesto L.)Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University/Montreal, Quebec/Canada (1 aut., 2 aut., 3 aut., 4 aut., 7 aut., 8 aut.); Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University/Montreal, Quebec/Canada (8 aut.); Université d'Avignon et des Pays de Vaucluse/Avignon/France (1 aut., 5 aut.); State University of Rio de Janeiro/Rio de Janeiro/Brésil (2 aut., 6 aut.)
Publication en série; Niveau analytique
Hypertension : (Dallas, Tex. 1979); ISSN 0194-911X; Coden HPRTDN; Etats-Unis; Da. 2011; Vol. 57; No. 3; Pp. 469-476; Bibl. 32 ref.AnglaisAngiotensin (Ang) II induces hypertension by mechanisms mediated in part by adaptive immunity and T effector lymphocytes. T regulatory lymphocytes (Tregs) suppress T effector lymphocytes. We questioned whether Treg adoptive transfer would blunt Ang II-induced hypertension and vascular injury. Ten- to 12-week-old male C57BL/6 mice were injected IV with 3 × 105 Treg (CD4+CD25+) or T effector (CD4+CD25-) cells, 3 times at 2-week intervals, and then infused or not with Ang II (1 μg/kg per minute, SC) for 14 days. Ang II increased systolic blood pressure by 43 mm Hg (P<0.05), NADPH oxidase activity 1.5-fold in aorta and 1.8-fold in the heart (P<0.05), impaired acetylcholine vasodilatory responses by 70% compared with control (P<0.05), and increased vascular stiffness (P<0.001), mesenteric artery vascular cell adhesion molecule expression (2-fold; P<0.05), and aortic macrophage and T-cell infiltration (P<0.001). All of the above were prevented by Treg but not T effector adoptive transfer. Ang II caused a 43% decrease in Foxp3+ cells in the renal cortex, whereas Treg adoptive transfer increased Foxp3+ cells 2-fold compared with control. Thus, Tregs suppress Ang II-mediated vascular injury in part through anti-inflammatory actions. Immune mechanisms modulate Ang II-induced blood pressure elevation, vascular oxidative stress, inflammation, and endothelial dysfunction.002B12B05; 002B12B05BHypertension artérielle; Pathologie de l'appareil circulatoire; Lymphocyte T; Angiotensine II; Immunité; Inflammation; Cytokine; Pression artérielle; Pression sanguine; Remodelage vasculaireHormone peptide; OctapeptideHypertension; Cardiovascular disease; T-Lymphocyte; Angiotensin II; Immunity; Inflammation; Cytokine; Arterial pressure; Blood pressure; Vascular remodelingPeptide hormone; OctapeptideHipertensión arterial; Aparato circulatorio patología; Linfocito T; Angiotensina II; Inmunidad; Inflamación; Citoquina; Presión arterial; Presión sanguínea; Remodelado vascularINIST-18059.35400019197277020011-0119541 001644 Thrombospondin-1 Is a Plasmatic Marker of Peripheral Arterial Disease That Modulates Endothelial Progenitor Cell Angiogenic PropertiesDavid M. SmadjaUniversité Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.INSERM UMRS 765ParisFRA1 aut.2 aut.4 aut.5 aut.9 aut.10 aut.12 aut.17 aut.18 aut.Clément D AudigierUniversité Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.INSERM UMRS 765ParisFRA1 aut.2 aut.4 aut.5 aut.9 aut.10 aut.12 aut.17 aut.18 aut.Ivan BiecheUniversité Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.AP-HP Hôpital Européen Georges PompidouParisFRA3 aut.INSERM UMRS 745ParisFRA3 aut.8 aut.Solène EvrardUniversité Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.INSERM UMRS 765ParisFRA1 aut.2 aut.4 aut.5 aut.9 aut.10 aut.12 aut.17 aut.18 aut.Laetitia MaugeUniversité Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.INSERM UMRS 765ParisFRA1 aut.2 aut.4 aut.5 aut.9 aut.10 aut.12 aut.17 aut.18 aut.Juliana-Vieira DiasDepartamento de Biologia Celular (J.-V.D., V.M.), Universidade do Estado do Rio de JaneiroBRA6 aut.13 aut.Julien LabreucheINSERM UMRS 698ParisFRA7 aut.Ingrid LaurendeauUniversité Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.INSERM UMRS 745ParisFRA3 aut.8 aut.Bérengère MarsacUniversité Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.INSERM UMRS 765ParisFRA1 aut.2 aut.4 aut.5 aut.9 aut.10 aut.12 aut.17 aut.18 aut.Blandine DizierUniversité Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.INSERM UMRS 765ParisFRA1 aut.2 aut.4 aut.5 aut.9 aut.10 aut.12 aut.17 aut.18 aut.Orianne Wagner-BallonINSERM UMRS 1009ParisFRA11 aut.Catherine Boisson-VidalUniversité Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.INSERM UMRS 765ParisFRA1 aut.2 aut.4 aut.5 aut.9 aut.10 aut.12 aut.17 aut.18 aut.Verônica MorandiDepartamento de Biologia Celular (J.-V.D., V.M.), Universidade do Estado do Rio de JaneiroBRA6 aut.13 aut.Jean-Paul Duong-Van-HuyenINSERM UMRS 872ParisFRA14 aut.15 aut.Patrick BrunevalINSERM UMRS 872ParisFRA14 aut.15 aut.Françoise Dignat-GeorgeINSERM UMRS 608ParisFRA16 aut.Joseph EmmerichUniversité Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.INSERM UMRS 765ParisFRA1 aut.2 aut.4 aut.5 aut.9 aut.10 aut.12 aut.17 aut.18 aut.Pascale GaussemUniversité Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.INSERM UMRS 765ParisFRA1 aut.2 aut.4 aut.5 aut.9 aut.10 aut.12 aut.17 aut.18 aut.11-01212122011PASCAL 11-0121212 INISTPascal:11-01212120012541079-5642Arterioscler. thromb. vasc. biol.Arteriosclerosis, thrombosis, and vascular biologyAngiogenesisArtery thrombosisAtherosclerosisCardiovascular diseaseEndothelial cellOcclusive arterial diseaseProgenitor cellThrombospondinArtériopathie oblitéranteThrombose des artèresPathologie de l'appareil circulatoireAthéroscléroseThrombospondineCellule endothélialeCellule progéniteurAngiogenèse
Objective-We examined whether plasma levels of angiogenic factors are altered in plasma of patients with peripheral arterial disease (PAD) and whether these factors affect endothelial progenitor cell-induced angiogenesis. Methods and Results-Plasma was collected from 184 patients with PAD and 330 age-matched healthy controls. Vascular endothelial growth factor and placental growth factor concentrations did not differ between the groups, whereas we found a linear correlation between PAD disease and thrombospondin (TSP)-1 plasma level. TSP-1 was expressed in newly formed vessels in PAD patients having received local injections of bone marrow mononuclear cells. To analyze the functional role of TSP-1 during neoangiogenesis, we used a Matrigel-plug assay and showed that vascularization of implanted Matrigel-plugs was increased in TSP-1-/- mice. Moreover, injections of TSP-1 in C57B16/J mice after hindlimb ischemia induced a significant decrease of blood flow recovery. To investigate the effects of TSP-1 on human endothelial colony-forming cell (ECFC) angiogenic potential, recombinant human TSP-1 and a small interfering RNA were used. In vitro, TSP-1 N-terminal part significantly enhanced ECFC adhesion, whereas recombinant human TSP-1 had a negative effect on ECFC angiogenic potential. This effect, mediated by CD47 binding, modulated stromal cell-derived factor 1/CXC chemokine receptor 4 pathway. Conclusion-TSP-1 is a potential biomarker of PAD and ECFC-induced angiogenesis, suggesting that TSP-1 modulation might improve local tissue ischemia in this setting.
1079-5642ATVBFAArterioscler. thromb. vasc. biol.313Thrombospondin-1 Is a Plasmatic Marker of Peripheral Arterial Disease That Modulates Endothelial Progenitor Cell Angiogenic PropertiesSMADJA (David M.)D'AUDIGIER (Clément)BIECHE (Ivan)EVRARD (Solène)MAUGE (Laetitia)DIAS (Juliana-Vieira)LABREUCHE (Julien)LAURENDEAU (Ingrid)MARSAC (Bérengère)DIZIER (Blandine)WAGNER-BALLON (Orianne)BOISSON-VIDAL (Catherine)MORANDI (Verônica)DUONG-VAN-HUYEN (Jean-Paul)BRUNEVAL (Patrick)DIGNAT-GEORGE (Françoise)EMMERICH (Joseph)GAUSSEM (Pascale)Université Paris DescartesParisFRA1 aut.2 aut.3 aut.4 aut.5 aut.8 aut.9 aut.10 aut.12 aut.17 aut.18 aut.INSERM UMRS 765ParisFRA1 aut.2 aut.4 aut.5 aut.9 aut.10 aut.12 aut.17 aut.18 aut.AP-HP Hôpital Européen Georges PompidouParisFRA3 aut.INSERM UMRS 745ParisFRA3 aut.8 aut.Departamento de Biologia Celular (J.-V.D., V.M.), Universidade do Estado do Rio de JaneiroBRA6 aut.13 aut.INSERM UMRS 698ParisFRA7 aut.INSERM UMRS 1009ParisFRA11 aut.INSERM UMRS 872ParisFRA14 aut.15 aut.INSERM UMRS 608ParisFRA16 aut.551-5592011ENGINIST191043540001943993501300000© 2011 INIST-CNRS. All rights reserved.41 ref.11-0121212PAArteriosclerosis, thrombosis, and vascular biologyUSAObjective-We examined whether plasma levels of angiogenic factors are altered in plasma of patients with peripheral arterial disease (PAD) and whether these factors affect endothelial progenitor cell-induced angiogenesis. Methods and Results-Plasma was collected from 184 patients with PAD and 330 age-matched healthy controls. Vascular endothelial growth factor and placental growth factor concentrations did not differ between the groups, whereas we found a linear correlation between PAD disease and thrombospondin (TSP)-1 plasma level. TSP-1 was expressed in newly formed vessels in PAD patients having received local injections of bone marrow mononuclear cells. To analyze the functional role of TSP-1 during neoangiogenesis, we used a Matrigel-plug assay and showed that vascularization of implanted Matrigel-plugs was increased in TSP-1-/- mice. Moreover, injections of TSP-1 in C57B16/J mice after hindlimb ischemia induced a significant decrease of blood flow recovery. To investigate the effects of TSP-1 on human endothelial colony-forming cell (ECFC) angiogenic potential, recombinant human TSP-1 and a small interfering RNA were used. In vitro, TSP-1 N-terminal part significantly enhanced ECFC adhesion, whereas recombinant human TSP-1 had a negative effect on ECFC angiogenic potential. This effect, mediated by CD47 binding, modulated stromal cell-derived factor 1/CXC chemokine receptor 4 pathway. Conclusion-TSP-1 is a potential biomarker of PAD and ECFC-induced angiogenesis, suggesting that TSP-1 modulation might improve local tissue ischemia in this setting.002B12B01002B12B03002A22DArtériopathie oblitérante01Occlusive arterial disease01Arteriopatía oclusiva01Thrombose des artèresNM02Artery thrombosisNM02Thrombose arteriaNM02Pathologie de l'appareil circulatoire03Cardiovascular disease03Aparato circulatorio patología03AthéroscléroseNM04AtherosclerosisNM04AteroesclerosisNM04Thrombospondine09Thrombospondin09Trombospondina09Cellule endothéliale10Endothelial cell10Célula endotelial10Cellule progéniteur11Progenitor cell11Célula progenitor11Angiogenèse12Angiogenesis12Angiogénesis12Pathologie des artères37Arterial disease37Arteria patología37Pathologie des vaisseaux sanguins38Vascular disease38Vaso sanguíneo patología38080OTOOTOPASCAL 11-0121212 INISTThrombospondin-1 Is a Plasmatic Marker of Peripheral Arterial Disease That Modulates Endothelial Progenitor Cell Angiogenic PropertiesSMADJA (David M.); D'AUDIGIER (Clément); BIECHE (Ivan); EVRARD (Solène); MAUGE (Laetitia); DIAS (Juliana-Vieira); LABREUCHE (Julien); LAURENDEAU (Ingrid); MARSAC (Bérengère); DIZIER (Blandine); WAGNER-BALLON (Orianne); BOISSON-VIDAL (Catherine); MORANDI (Verônica); DUONG-VAN-HUYEN (Jean-Paul); BRUNEVAL (Patrick); DIGNAT-GEORGE (Françoise); EMMERICH (Joseph); GAUSSEM (Pascale)Université Paris Descartes/Paris/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 8 aut., 9 aut., 10 aut., 12 aut., 17 aut., 18 aut.); INSERM UMRS 765/Paris/France (1 aut., 2 aut., 4 aut., 5 aut., 9 aut., 10 aut., 12 aut., 17 aut., 18 aut.); AP-HP Hôpital Européen Georges Pompidou/Paris/France (3 aut.); INSERM UMRS 745/Paris/France (3 aut., 8 aut.); Departamento de Biologia Celular (J.-V.D., V.M.), Universidade do Estado do Rio de Janeiro/Brésil (6 aut., 13 aut.); INSERM UMRS 698/Paris/France (7 aut.); INSERM UMRS 1009/Paris/France (11 aut.); INSERM UMRS 872/Paris/France (14 aut., 15 aut.); INSERM UMRS 608/Paris/France (16 aut.)
Publication en série; Niveau analytique
Arteriosclerosis, thrombosis, and vascular biology; ISSN 1079-5642; Coden ATVBFA; Etats-Unis; Da. 2011; Vol. 31; No. 3; Pp. 551-559; Bibl. 41 ref.AnglaisObjective-We examined whether plasma levels of angiogenic factors are altered in plasma of patients with peripheral arterial disease (PAD) and whether these factors affect endothelial progenitor cell-induced angiogenesis. Methods and Results-Plasma was collected from 184 patients with PAD and 330 age-matched healthy controls. Vascular endothelial growth factor and placental growth factor concentrations did not differ between the groups, whereas we found a linear correlation between PAD disease and thrombospondin (TSP)-1 plasma level. TSP-1 was expressed in newly formed vessels in PAD patients having received local injections of bone marrow mononuclear cells. To analyze the functional role of TSP-1 during neoangiogenesis, we used a Matrigel-plug assay and showed that vascularization of implanted Matrigel-plugs was increased in TSP-1-/- mice. Moreover, injections of TSP-1 in C57B16/J mice after hindlimb ischemia induced a significant decrease of blood flow recovery. To investigate the effects of TSP-1 on human endothelial colony-forming cell (ECFC) angiogenic potential, recombinant human TSP-1 and a small interfering RNA were used. In vitro, TSP-1 N-terminal part significantly enhanced ECFC adhesion, whereas recombinant human TSP-1 had a negative effect on ECFC angiogenic potential. This effect, mediated by CD47 binding, modulated stromal cell-derived factor 1/CXC chemokine receptor 4 pathway. Conclusion-TSP-1 is a potential biomarker of PAD and ECFC-induced angiogenesis, suggesting that TSP-1 modulation might improve local tissue ischemia in this setting.002B12B01; 002B12B03; 002A22DArtériopathie oblitérante; Thrombose des artères; Pathologie de l'appareil circulatoire; Athérosclérose; Thrombospondine; Cellule endothéliale; Cellule progéniteur; AngiogenèsePathologie des artères; Pathologie des vaisseaux sanguinsOcclusive arterial disease; Artery thrombosis; Cardiovascular disease; Atherosclerosis; Thrombospondin; Endothelial cell; Progenitor cell; AngiogenesisArterial disease; Vascular diseaseArteriopatía oclusiva; Thrombose arteria; Aparato circulatorio patología; Ateroesclerosis; Trombospondina; Célula endotelial; Célula progenitor; AngiogénesisINIST-19104.35400019439935013011-0121212 001645 Composition of a volatile extract of Eryngium duriaei subsp. juresianum (M. Laínz) M. Laínz, signalised by the antifungal activityCarlos CavaleiroCentro de Estudos Farmacêuticos/Faculdade de Farmácia, Universidade de Coimbra3000-548 CoimbraPRT1 aut.2 aut.3 aut.4 aut.7 aut.Maria José GoncalvesCentro de Estudos Farmacêuticos/Faculdade de Farmácia, Universidade de Coimbra3000-548 CoimbraPRT1 aut.2 aut.3 aut.4 aut.7 aut.Diana SerraCentro de Estudos Farmacêuticos/Faculdade de Farmácia, Universidade de Coimbra3000-548 CoimbraPRT1 aut.2 aut.3 aut.4 aut.7 aut.Giani SantoroCentro de Estudos Farmacêuticos/Faculdade de Farmácia, Universidade de Coimbra3000-548 CoimbraPRT1 aut.2 aut.3 aut.4 aut.7 aut.Laboratório de Biologia Celular de Microrganismos, Departamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz/FIOCRUZRio de JaneiroBRA4 aut.Felix TomiUniversité de Corse-CNRS, UMR 6134 SPE, Equipe Chimie et BiomasseAjaccioFRA5 aut.6 aut.8 aut.Ange BighelliUniversité de Corse-CNRS, UMR 6134 SPE, Equipe Chimie et BiomasseAjaccioFRA5 aut.6 aut.8 aut.Ligia SalgueiroCentro de Estudos Farmacêuticos/Faculdade de Farmácia, Universidade de Coimbra3000-548 CoimbraPRT1 aut.2 aut.3 aut.4 aut.7 aut.Joseph CasanovaUniversité de Corse-CNRS, UMR 6134 SPE, Equipe Chimie et BiomasseAjaccioFRA5 aut.6 aut.8 aut.11-01221872011PASCAL 11-0122187 INISTPascal:11-01221870012530731-7085J. pharm. biomed. anal.Journal of pharmaceutical and biomedical analysisAntifungal agentEssential oilExtractHydrocarbonSesquiterpenesTerpenoidUmbelliferaeVolatile compoundComposé volatilExtraitAntifongiqueHuile essentielleUmbelliferaeHydrocarbureSesquiterpèneTerpénoïdeEryngiumCaryophyllèneCaryophyllane dérivé
The composition of a volatile extract of Eryngium duriaei subsp. juresianum, signalised by the antifungal activity (MIC values = 0.16-0.32 μL mL-1) against several dermatophyte species (Trichophyton mentagrophytes, T. rubrum, Epidermophyton floccosum; T. verrucosum, T. mentagrophytes var interdigitale, Microsporum canis and M. gypseum) was established following a combined methodology of GC, GC-MS and an exclusive 13C NMR technique that does not require prior isolation of compounds. Twenty-five components were identified accounting 84.6% of the whole composition. Major compound was found to be α-neocallitropsene (26.0%) although the dominance of caryophyllane derived compounds, the most probable responsible for the antifungal activity, namely isocaryophyllen-14-al (16.2%), 14-hidroxy-β-caryophyllene (13.4%), caryophyllene oxide (7.6%) and E-β-caryophyllene (6.3%).
0731-7085JPBADAJ. pharm. biomed. anal.543Composition of a volatile extract of Eryngium duriaei subsp. juresianum (M. Laínz) M. Laínz, signalised by the antifungal activityCAVALEIRO (Carlos)GONCALVES (Maria José)SERRA (Diana)SANTORO (Giani)TOMI (Felix)BIGHELLI (Ange)SALGUEIRO (Ligia)CASANOVA (Joseph)Centro de Estudos Farmacêuticos/Faculdade de Farmácia, Universidade de Coimbra3000-548 CoimbraPRT1 aut.2 aut.3 aut.4 aut.7 aut.Laboratório de Biologia Celular de Microrganismos, Departamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz/FIOCRUZRio de JaneiroBRA4 aut.Université de Corse-CNRS, UMR 6134 SPE, Equipe Chimie et BiomasseAjaccioFRA5 aut.6 aut.8 aut.619-6222011ENGINIST199623540001919775603200000© 2011 INIST-CNRS. All rights reserved.22 ref.11-0122187PCCAJournal of pharmaceutical and biomedical analysisNLDThe composition of a volatile extract of Eryngium duriaei subsp. juresianum, signalised by the antifungal activity (MIC values = 0.16-0.32 μL mL-1) against several dermatophyte species (Trichophyton mentagrophytes, T. rubrum, Epidermophyton floccosum; T. verrucosum, T. mentagrophytes var interdigitale, Microsporum canis and M. gypseum) was established following a combined methodology of GC, GC-MS and an exclusive 13C NMR technique that does not require prior isolation of compounds. Twenty-five components were identified accounting 84.6% of the whole composition. Major compound was found to be α-neocallitropsene (26.0%) although the dominance of caryophyllane derived compounds, the most probable responsible for the antifungal activity, namely isocaryophyllen-14-al (16.2%), 14-hidroxy-β-caryophyllene (13.4%), caryophyllene oxide (7.6%) and E-β-caryophyllene (6.3%).002B02A02002A02Composé volatilFX01Volatile compoundFX01Compuesto volátilFX01Extrait02Extract02Extracto02Antifongique03Antifungal agent03Antifúngico03Huile essentielle04Essential oil04Aceite esencial04UmbelliferaeNS23UmbelliferaeNS23UmbelliferaeNS23HydrocarbureFX24HydrocarbonFX24HidrocarburoFX24Sesquiterpène25Sesquiterpenes25Sesquiterpeno25TerpénoïdeFX26TerpenoidFX26TerpenoideFX26EryngiumINC86CaryophyllèneINC87Caryophyllane dérivéINC88DicotyledonesNSDicotyledonesNSDicotyledonesNSAngiospermaeNSAngiospermaeNSAngiospermaeNSSpermatophytaNSSpermatophytaNSSpermatophytaNS080OTOOTOPASCAL 11-0122187 INISTComposition of a volatile extract of Eryngium duriaei subsp. juresianum (M. Laínz) M. Laínz, signalised by the antifungal activityCAVALEIRO (Carlos); GONCALVES (Maria José); SERRA (Diana); SANTORO (Giani); TOMI (Felix); BIGHELLI (Ange); SALGUEIRO (Ligia); CASANOVA (Joseph)Centro de Estudos Farmacêuticos/Faculdade de Farmácia, Universidade de Coimbra/3000-548 Coimbra/Portugal (1 aut., 2 aut., 3 aut., 4 aut., 7 aut.); Laboratório de Biologia Celular de Microrganismos, Departamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz/FIOCRUZ/Rio de Janeiro/Brésil (4 aut.); Université de Corse-CNRS, UMR 6134 SPE, Equipe Chimie et Biomasse/Ajaccio/France (5 aut., 6 aut., 8 aut.)
Publication en série; Courte communication, note brève; Niveau analytique
Journal of pharmaceutical and biomedical analysis; ISSN 0731-7085; Coden JPBADA; Pays-Bas; Da. 2011; Vol. 54; No. 3; Pp. 619-622; Bibl. 22 ref.AnglaisThe composition of a volatile extract of Eryngium duriaei subsp. juresianum, signalised by the antifungal activity (MIC values = 0.16-0.32 μL mL-1) against several dermatophyte species (Trichophyton mentagrophytes, T. rubrum, Epidermophyton floccosum; T. verrucosum, T. mentagrophytes var interdigitale, Microsporum canis and M. gypseum) was established following a combined methodology of GC, GC-MS and an exclusive 13C NMR technique that does not require prior isolation of compounds. Twenty-five components were identified accounting 84.6% of the whole composition. Major compound was found to be α-neocallitropsene (26.0%) although the dominance of caryophyllane derived compounds, the most probable responsible for the antifungal activity, namely isocaryophyllen-14-al (16.2%), 14-hidroxy-β-caryophyllene (13.4%), caryophyllene oxide (7.6%) and E-β-caryophyllene (6.3%).002B02A02; 002A02Composé volatil; Extrait; Antifongique; Huile essentielle; Umbelliferae; Hydrocarbure; Sesquiterpène; Terpénoïde; Eryngium; Caryophyllène; Caryophyllane dérivéDicotyledones; Angiospermae; SpermatophytaVolatile compound; Extract; Antifungal agent; Essential oil; Umbelliferae; Hydrocarbon; Sesquiterpenes; TerpenoidDicotyledones; Angiospermae; SpermatophytaCompuesto volátil; Extracto; Antifúngico; Aceite esencial; Umbelliferae; Hidrocarburo; Sesquiterpeno; TerpenoideINIST-19962.35400019197756032011-0122187 001646 Numerical modeling of large strain behavior of polymeric crushable foamsG. C. MachadoLaboratoire 3S-R, Université de Grenoble/CNRS, Cedex 938041 GrenobleFRA1 aut.M. K. AlvesDepartamento de Engenharia Mecânica, Universidade Federal de Santa CatarinaFlorianópolis 88010-970, SCBRA2 aut.R. RossiDepartamento de Engenharia Mecânica, Universidade Federal do Rio Grande do SulPorto Alegre 90046-902, RSBRA3 aut.C. R. A. Jr SilvaDepartamento de Engenharia Mecânica, Universidade Tecnológica Federal do ParanáCuritiba 80230-901, PRBRA4 aut.11-01245052011PASCAL 11-0124505 INISTPascal:11-01245050012520307-904XAppl. math. model.Applied mathematical modellingAugmented LagrangianCell structureCellular plasticConstitutive equationFinite element methodFrictionGalerkin methodHigh strainHydrostaticsLagrange coordinateLagrangian methodLeast squares methodLogarithmic functionMechanical contactMeshless methodModelingPolymerPorous materialUnilateralGrande déformationHydrostatiqueContact mécaniqueUnilatéralFrottementPlastique alvéolairePolymèreStructure cellulaireMatériau poreuxModélisationEquation constitutiveFonction logarithmiqueMéthode élément finiMéthode moindre carréMéthode sans mailleMéthode GalerkinCoordonnée LagrangeLagrangien augmentéMéthode Lagrange.
This paper describes a constitutive law modeling isotropic polymeric foam materials. Focus has been placed on modeling the relative density dependency effect on polymeric foams subjected to large deformations using uniaxial and hydrostatic compressive hardening laws. The constitutive model is written in terms of the rotated Kirchhoff stress and of its conjugate logarithmic, or Hencky, strain measure. A numerical scheme for solving the constitutive model is described and implemented using both the finite element and the element-free Galerkin methods, in a Total Lagrangian finite strain framework. The imposition of the unilateral contact with friction and the essential boundary conditions are obtained by applying the Augmented Lagrangian method. Numerical examples are presented in order to attest the performance of the proposed constitutive model.
0307-904XAMMODLAppl. math. model.353Numerical modeling of large strain behavior of polymeric crushable foamsMACHADO (G. C.)ALVES (M. K.)ROSSI (R.)SILVA (C. R. A. JR)Laboratoire 3S-R, Université de Grenoble/CNRS, Cedex 938041 GrenobleFRA1 aut.Departamento de Engenharia Mecânica, Universidade Federal de Santa CatarinaFlorianópolis 88010-970, SCBRA2 aut.Departamento de Engenharia Mecânica, Universidade Federal do Rio Grande do SulPorto Alegre 90046-902, RSBRA3 aut.Departamento de Engenharia Mecânica, Universidade Tecnológica Federal do ParanáCuritiba 80230-901, PRBRA4 aut.1271-12812011ENGINIST175083540001943760802500000© 2011 INIST-CNRS. All rights reserved.26 ref.11-0124505PAApplied mathematical modellingGBRThis paper describes a constitutive law modeling isotropic polymeric foam materials. Focus has been placed on modeling the relative density dependency effect on polymeric foams subjected to large deformations using uniaxial and hydrostatic compressive hardening laws. The constitutive model is written in terms of the rotated Kirchhoff stress and of its conjugate logarithmic, or Hencky, strain measure. A numerical scheme for solving the constitutive model is described and implemented using both the finite element and the element-free Galerkin methods, in a Total Lagrangian finite strain framework. The imposition of the unilateral contact with friction and the essential boundary conditions are obtained by applying the Augmented Lagrangian method. Numerical examples are presented in order to attest the performance of the proposed constitutive model.001B40F30C001D10A06A001A02I02001B40F30PGrande déformation06High strain06Gran deformación06Hydrostatique07Hydrostatics07Hidrostática07Contact mécanique08Mechanical contact08Contacto mecánico08Unilatéral09Unilateral09Unilateral09Frottement10Friction10Frotamiento10Plastique alvéolaire15Cellular plastic15Plástico espumoso15Polymère16Polymer16Polímero16Structure cellulaire17Cell structure17Estructura celular17Matériau poreux18Porous material18Material poroso18Modélisation23Modeling23Modelización23Equation constitutive24Constitutive equation24Ecuación constitutiva24Fonction logarithmique25Logarithmic function25Función logarítmica25Méthode élément fini26Finite element method26Método elemento finito26Méthode moindre carré27Least squares method27Método cuadrado menor27Méthode sans maille28Meshless method28Método sin malla28Méthode Galerkin29Galerkin method29Método Galerkin29Coordonnée Lagrange30Lagrange coordinate30Coordenada Lagrange30Lagrangien augmenté31Augmented Lagrangian31Lagrangiano aumentado31Méthode Lagrange32Lagrangian method32Método Lagrange32.INC82Matière plastiquePlasticsMaterial plástico080OTOOTOPASCAL 11-0124505 INISTNumerical modeling of large strain behavior of polymeric crushable foamsMACHADO (G. C.); ALVES (M. K.); ROSSI (R.); SILVA (C. R. A. JR)Laboratoire 3S-R, Université de Grenoble/CNRS, Cedex 9/38041 Grenoble/France (1 aut.); Departamento de Engenharia Mecânica, Universidade Federal de Santa Catarina/Florianópolis 88010-970, SC/Brésil (2 aut.); Departamento de Engenharia Mecânica, Universidade Federal do Rio Grande do Sul/Porto Alegre 90046-902, RS/Brésil (3 aut.); Departamento de Engenharia Mecânica, Universidade Tecnológica Federal do Paraná/Curitiba 80230-901, PR/Brésil (4 aut.)
Publication en série; Niveau analytique
Applied mathematical modelling; ISSN 0307-904X; Coden AMMODL; Royaume-Uni; Da. 2011; Vol. 35; No. 3; Pp. 1271-1281; Bibl. 26 ref.AnglaisThis paper describes a constitutive law modeling isotropic polymeric foam materials. Focus has been placed on modeling the relative density dependency effect on polymeric foams subjected to large deformations using uniaxial and hydrostatic compressive hardening laws. The constitutive model is written in terms of the rotated Kirchhoff stress and of its conjugate logarithmic, or Hencky, strain measure. A numerical scheme for solving the constitutive model is described and implemented using both the finite element and the element-free Galerkin methods, in a Total Lagrangian finite strain framework. The imposition of the unilateral contact with friction and the essential boundary conditions are obtained by applying the Augmented Lagrangian method. Numerical examples are presented in order to attest the performance of the proposed constitutive model.001B40F30C; 001D10A06A; 001A02I02; 001B40F30PGrande déformation; Hydrostatique; Contact mécanique; Unilatéral; Frottement; Plastique alvéolaire; Polymère; Structure cellulaire; Matériau poreux; Modélisation; Equation constitutive; Fonction logarithmique; Méthode élément fini; Méthode moindre carré; Méthode sans maille; Méthode Galerkin; Coordonnée Lagrange; Lagrangien augmenté; Méthode Lagrange; .Matière plastiqueHigh strain; Hydrostatics; Mechanical contact; Unilateral; Friction; Cellular plastic; Polymer; Cell structure; Porous material; Modeling; Constitutive equation; Logarithmic function; Finite element method; Least squares method; Meshless method; Galerkin method; Lagrange coordinate; Augmented Lagrangian; Lagrangian methodPlasticsGran deformación; Hidrostática; Contacto mecánico; Unilateral; Frotamiento; Plástico espumoso; Polímero; Estructura celular; Material poroso; Modelización; Ecuación constitutiva; Función logarítmica; Método elemento finito; Método cuadrado menor; Método sin malla; Método Galerkin; Coordenada Lagrange; Lagrangiano aumentado; Método LagrangeINIST-17508.35400019437608025011-0124505 001647 ANALYSE LEXICALE AUTOUR DES CONCEPTS DE GRAS ET DE VOLUME DANS LES VINSYves Le FurCentre des Sciences du Goût et de l'Alimentation, UMR 6265 CNRS, UMR 1324 INRA, Université de Bourgogne, AgroSup Dijon - 15, rue Hugues Picardet21000 DijonFRA1 aut.2 aut.3 aut.Emilie TeyssotCentre des Sciences du Goût et de l'Alimentation, UMR 6265 CNRS, UMR 1324 INRA, Université de Bourgogne, AgroSup Dijon - 15, rue Hugues Picardet21000 DijonFRA1 aut.2 aut.3 aut.Nathalie Vieira FozCentre des Sciences du Goût et de l'Alimentation, UMR 6265 CNRS, UMR 1324 INRA, Université de Bourgogne, AgroSup Dijon - 15, rue Hugues Picardet21000 DijonFRA1 aut.2 aut.3 aut.Université Fédérale de Santa Catarina, Centre des sciences agricolesn - 1346, Admar Gonzaga, Ouartier Itacorubi, FlorianópolisSanta CatarinaBRA3 aut.Cécile FoissyInstitut Œnologique de Champagne, ZI de Mardeuil, Route de Cumières, BP 2551201 ÉpernayFRA4 aut.5 aut.6 aut.Guillaume Le BrasInstitut Œnologique de Champagne, ZI de Mardeuil, Route de Cumières, BP 2551201 ÉpernayFRA4 aut.5 aut.6 aut.Bertrand RobillardInstitut Œnologique de Champagne, ZI de Mardeuil, Route de Cumières, BP 2551201 ÉpernayFRA4 aut.5 aut.6 aut.11-01259762010PASCAL 11-0125976 INISTPascal:11-01259760012510395-899XRev. fr. oenol.Revue française d'oenologieAnalysisProfessionalSampleVolumeWineAnalyseVolumeVinEchantillonProfessionnel
Deux questionnaires envoyés à un panel de professionnels et à un panel de non professionnels ont permis de cerner quels étaient les qualificatifs les mieux associés aux concepts de vin gras et de vin ayant du volume. Ainsi, pour chaque concept étudié par chacun des deux panels, trois tests de verbalisation (test d'association libre combiné à une analyse des termes cités spontanément en ordre 1, test de définition et test de synonymie) ont été traités par analyse lexicale selon la méthode des fréquences d'occurrence. L'un des résultats les plus significatifs est que le concept de vin ayant du volume est plus global que celui de vin gras: le gras est une des nombreuses dimensions du volume et, contrairement au terme rondeur, volume n'est pas l'exact synonyme de gras. Les termes saillants relatifs au concept de vin gras se situent dans le registre des sensations à la fois tactiles et hédoniques. De plus, le concept de vin gras est souvent illustré par des exemples de vin particulier.A contrario, aucun exemple de vin ne vient illustrer le concept de vin ayant du volume qui se trouve donc dégagé de toute typologie, mais qui renvoie à des notions plus générales d'amplitude, de texture, de présence en bouche, de persistance, de structure, voire d'équilibre.
0395-899XRev. fr. oenol.244ANALYSE LEXICALE AUTOUR DES CONCEPTS DE GRAS ET DE VOLUME DANS LES VINSLE FUR (Yves)TEYSSOT (Emilie)VIEIRA FOZ (Nathalie)FOISSY (Cécile)LE BRAS (Guillaume)ROBILLARD (Bertrand)Centre des Sciences du Goût et de l'Alimentation, UMR 6265 CNRS, UMR 1324 INRA, Université de Bourgogne, AgroSup Dijon - 15, rue Hugues Picardet21000 DijonFRA1 aut.2 aut.3 aut.Institut Œnologique de Champagne, ZI de Mardeuil, Route de Cumières, BP 2551201 ÉpernayFRA4 aut.5 aut.6 aut.Université Fédérale de Santa Catarina, Centre des sciences agricolesn - 1346, Admar Gonzaga, Ouartier Itacorubi, FlorianópolisSanta CatarinaBRA3 aut.26-302010FREengINIST139213540001919521400500000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0125976PARevue française d'oenologieFRADeux questionnaires envoyés à un panel de professionnels et à un panel de non professionnels ont permis de cerner quels étaient les qualificatifs les mieux associés aux concepts de vin gras et de vin ayant du volume. Ainsi, pour chaque concept étudié par chacun des deux panels, trois tests de verbalisation (test d'association libre combiné à une analyse des termes cités spontanément en ordre 1, test de définition et test de synonymie) ont été traités par analyse lexicale selon la méthode des fréquences d'occurrence. L'un des résultats les plus significatifs est que le concept de vin ayant du volume est plus global que celui de vin gras: le gras est une des nombreuses dimensions du volume et, contrairement au terme rondeur, volume n'est pas l'exact synonyme de gras. Les termes saillants relatifs au concept de vin gras se situent dans le registre des sensations à la fois tactiles et hédoniques. De plus, le concept de vin gras est souvent illustré par des exemples de vin particulier.A contrario, aucun exemple de vin ne vient illustrer le concept de vin ayant du volume qui se trouve donc dégagé de toute typologie, mais qui renvoie à des notions plus générales d'amplitude, de texture, de présence en bouche, de persistance, de structure, voire d'équilibre.002A35C03Analyse01Analysis01Análisis01Volume02Volume02Volumen02Vin10Wine10Vino10Echantillon19Sample19Muestra19ProfessionnelCD96ProfessionalCD96ProfesionalCD96Boisson alcooliséeFX08Alcoholic beverageFX08Bebida alcohólicaFX08080OTOOTOPASCAL 11-0125976 INISTANALYSE LEXICALE AUTOUR DES CONCEPTS DE GRAS ET DE VOLUME DANS LES VINSLE FUR (Yves); TEYSSOT (Emilie); VIEIRA FOZ (Nathalie); FOISSY (Cécile); LE BRAS (Guillaume); ROBILLARD (Bertrand)Centre des Sciences du Goût et de l'Alimentation, UMR 6265 CNRS, UMR 1324 INRA, Université de Bourgogne, AgroSup Dijon - 15, rue Hugues Picardet/21000 Dijon/France (1 aut., 2 aut., 3 aut.); Institut Œnologique de Champagne, ZI de Mardeuil, Route de Cumières, BP 25/51201 Épernay/France (4 aut., 5 aut., 6 aut.); Université Fédérale de Santa Catarina, Centre des sciences agricolesn - 1346, Admar Gonzaga, Ouartier Itacorubi, Florianópolis/Santa Catarina/Brésil (3 aut.)
Publication en série; Niveau analytique
Revue française d'oenologie; ISSN 0395-899X; France; Da. 2010; No. 244; Pp. 26-30; Abs. anglais; Bibl. 3/4 p.FrançaisDeux questionnaires envoyés à un panel de professionnels et à un panel de non professionnels ont permis de cerner quels étaient les qualificatifs les mieux associés aux concepts de vin gras et de vin ayant du volume. Ainsi, pour chaque concept étudié par chacun des deux panels, trois tests de verbalisation (test d'association libre combiné à une analyse des termes cités spontanément en ordre 1, test de définition et test de synonymie) ont été traités par analyse lexicale selon la méthode des fréquences d'occurrence. L'un des résultats les plus significatifs est que le concept de vin ayant du volume est plus global que celui de vin gras: le gras est une des nombreuses dimensions du volume et, contrairement au terme rondeur, volume n'est pas l'exact synonyme de gras. Les termes saillants relatifs au concept de vin gras se situent dans le registre des sensations à la fois tactiles et hédoniques. De plus, le concept de vin gras est souvent illustré par des exemples de vin particulier.A contrario, aucun exemple de vin ne vient illustrer le concept de vin ayant du volume qui se trouve donc dégagé de toute typologie, mais qui renvoie à des notions plus générales d'amplitude, de texture, de présence en bouche, de persistance, de structure, voire d'équilibre.002A35C03Analyse; Volume; Vin; Echantillon; ProfessionnelBoisson alcooliséeAnalysis; Volume; Wine; Sample; ProfessionalAlcoholic beverageAnálisis; Volumen; Vino; Muestra; ProfesionalINIST-13921.35400019195214005011-0125976 001648 Copper, mercury and chromium adsorption on natural and crosslinked chitosan films: An XPS investigation of mechanismRodrigo S. VieiraDepartamento de Termofluidodinâmica, Faculdade de Engenharia Química, Universidade Estadual de Campinas, Caixa Postal 6066, Barão GeraldoCEP 13081-970, Campinas, SPBRA1 aut.5 aut.Mona Lisa M. OliveiraDepartamento de Quimica Inorgânica, Cristalografía y Mineralogía, Facultad de Ciencias, Unidad Asociada del Instituto de Catálisis y Petroleoquímica, CSIC, Universidad de Málaga, Campus de Teatinos29071 MálagaESP2 aut.4 aut.Eric GuibalEcole des Mines d'Alès, Laboratoire Génie de l'Environnement Industriel, 6 Avenue de Clavières30319 AlesFRA3 aut.Enrique Rodriguez-CastellonDepartamento de Quimica Inorgânica, Cristalografía y Mineralogía, Facultad de Ciencias, Unidad Asociada del Instituto de Catálisis y Petroleoquímica, CSIC, Universidad de Málaga, Campus de Teatinos29071 MálagaESP2 aut.4 aut.Marisa M. BeppuDepartamento de Termofluidodinâmica, Faculdade de Engenharia Química, Universidade Estadual de Campinas, Caixa Postal 6066, Barão GeraldoCEP 13081-970, Campinas, SPBRA1 aut.5 aut.11-01285332011PASCAL 11-0128533 INISTPascal:11-01285330012500927-7757Colloids surf., A Physicochem. eng. asp.Colloids and surfaces. A, Physicochemical and engineering aspectsAdsorbentAdsorptionAdsorption capacityAmino groupBindingBiopolymerChitosanChromiumChromium VIChromium ionComplexesCopperCopper IIElectron spectrometryFilmFocusingFunctional groupHeavy metalMechanismMercuryMercury ionMetal ionPhotoelectron spectrometryPolymerPotentialStabilizationStructureX rayCuivreMercureChromeAdsorptionChitosaneFilmSpectrométrie photoélectronRayon XMécanismeBiopolymèreMétal lourdFocalisationPotentielAdsorbantComplexeLiaisonPolymèreSpectrométrie électronIon métalliqueIon chromeIon mercureGroupe fonctionnelGroupe aminéStructureCuivre IIStabilisationCapacité adsorptionChrome VI
Although biopolymers are focusing the attention of researchers as potential adsorbents for heavy metal removal, little information is given about the properties of the resulting complexes. This information would also bring a better understanding of the mechanisms involved in metal binding to the polymer. XPS (X-ray photo-electron spectroscopy) is a powerful technique to investigate how metal ions bind onto these matrices. In this study, copper, chromium and mercury ions were adsorbed on natural and crosslinked (glutaraldehyde and epichlorohydrin) chitosan matrices, which present diverse functional groups and may induce different adsorption mechanisms. X-ray photoelectron spectroscopy (XPS) revealed that these metals bind to glutaraldehyde-crosslinked chitosan, differently from the other two kinds of matrices. Hence, amino group availability and the formation of new structures such as imino bonds are key factors. Copper(II) stabilization was found to be poor in glutaraldehyde-crosslinked chitosan. Conversely, Hg(II) ions present higher adsorption capacity in this kind of matrix. Chromium(VI) was reduced in all three matrices. In this case, chromium(VI) is probably not well stabilized by the functional groups of these polymers and may also undergo the action of their reducing groups.
0927-7757Colloids surf., A Physicochem. eng. asp.3741-3Copper, mercury and chromium adsorption on natural and crosslinked chitosan films: An XPS investigation of mechanismVIEIRA (Rodrigo S.)OLIVEIRA (Mona Lisa M.)GUIBAL (Eric)RODRIGUEZ-CASTELLON (Enrique)BEPPU (Marisa M.)Departamento de Termofluidodinâmica, Faculdade de Engenharia Química, Universidade Estadual de Campinas, Caixa Postal 6066, Barão GeraldoCEP 13081-970, Campinas, SPBRA1 aut.5 aut.Departamento de Quimica Inorgânica, Cristalografía y Mineralogía, Facultad de Ciencias, Unidad Asociada del Instituto de Catálisis y Petroleoquímica, CSIC, Universidad de Málaga, Campus de Teatinos29071 MálagaESP2 aut.4 aut.Ecole des Mines d'Alès, Laboratoire Génie de l'Environnement Industriel, 6 Avenue de Clavières30319 AlesFRA3 aut.108-1142011ENGINIST18274A3540001943304501600000© 2011 INIST-CNRS. All rights reserved.41 ref.11-0128533PAColloids and surfaces. A, Physicochemical and engineering aspectsGBRAlthough biopolymers are focusing the attention of researchers as potential adsorbents for heavy metal removal, little information is given about the properties of the resulting complexes. This information would also bring a better understanding of the mechanisms involved in metal binding to the polymer. XPS (X-ray photo-electron spectroscopy) is a powerful technique to investigate how metal ions bind onto these matrices. In this study, copper, chromium and mercury ions were adsorbed on natural and crosslinked (glutaraldehyde and epichlorohydrin) chitosan matrices, which present diverse functional groups and may induce different adsorption mechanisms. X-ray photoelectron spectroscopy (XPS) revealed that these metals bind to glutaraldehyde-crosslinked chitosan, differently from the other two kinds of matrices. Hence, amino group availability and the formation of new structures such as imino bonds are key factors. Copper(II) stabilization was found to be poor in glutaraldehyde-crosslinked chitosan. Conversely, Hg(II) ions present higher adsorption capacity in this kind of matrix. Chromium(VI) was reduced in all three matrices. In this case, chromium(VI) is probably not well stabilized by the functional groups of these polymers and may also undergo the action of their reducing groups.001C01ICuivreNC01CopperNC01CobreNC01MercureNCFX02MercuryNCFX02MercurioNCFX02ChromeNCFX03ChromiumNCFX03CromoNCFX03Adsorption04Adsorption04Adsorción04Chitosane05Chitosan05Quitosano05Film06Film06Película06Spectrométrie photoélectron07Photoelectron spectrometry07Espectrometría fotoelectrón07Rayon X08X ray08Rayos X08Mécanisme09Mechanism09Mecanismo09Biopolymère10Biopolymer10Biopolímero10Métal lourd11Heavy metal11Metal pesado11Focalisation13Focusing13Focalización13Potentiel14Potential14Potencial14Adsorbant15Adsorbent15Adsorbente15ComplexeNA16ComplexesNA16ComplejoNA16Liaison17Binding17Enlace17Polymère18Polymer18Polímero18Spectrométrie électron19Electron spectrometry19Espectrometría electrón19Ion métallique20Metal ion20Ión metálico20Ion chrome21Chromium ion21Cromo ión21Ion mercure22Mercury ion22Mercurio ión22Groupe fonctionnel23Functional group23Grupo funcional23Groupe aminé24Amino group24Grupo aminado24Structure25Structure25Estructura25Cuivre IINC26Copper IINC26Cobre IINC26Stabilisation27Stabilization27Estabilización27Capacité adsorption28Adsorption capacity28Capacidad adsorción28Chrome VINC29Chromium VINC29Cromo VINC29Métal transitionNC12Transition metalNC12Metal transiciónNC12087OTOOTOPASCAL 11-0128533 INISTCopper, mercury and chromium adsorption on natural and crosslinked chitosan films: An XPS investigation of mechanismVIEIRA (Rodrigo S.); OLIVEIRA (Mona Lisa M.); GUIBAL (Eric); RODRIGUEZ-CASTELLON (Enrique); BEPPU (Marisa M.)Departamento de Termofluidodinâmica, Faculdade de Engenharia Química, Universidade Estadual de Campinas, Caixa Postal 6066, Barão Geraldo/CEP 13081-970, Campinas, SP/Brésil (1 aut., 5 aut.); Departamento de Quimica Inorgânica, Cristalografía y Mineralogía, Facultad de Ciencias, Unidad Asociada del Instituto de Catálisis y Petroleoquímica, CSIC, Universidad de Málaga, Campus de Teatinos/29071 Málaga/Espagne (2 aut., 4 aut.); Ecole des Mines d'Alès, Laboratoire Génie de l'Environnement Industriel, 6 Avenue de Clavières/30319 Ales/France (3 aut.)
Publication en série; Niveau analytique
Colloids and surfaces. A, Physicochemical and engineering aspects; ISSN 0927-7757; Royaume-Uni; Da. 2011; Vol. 374; No. 1-3; Pp. 108-114; Bibl. 41 ref.AnglaisAlthough biopolymers are focusing the attention of researchers as potential adsorbents for heavy metal removal, little information is given about the properties of the resulting complexes. This information would also bring a better understanding of the mechanisms involved in metal binding to the polymer. XPS (X-ray photo-electron spectroscopy) is a powerful technique to investigate how metal ions bind onto these matrices. In this study, copper, chromium and mercury ions were adsorbed on natural and crosslinked (glutaraldehyde and epichlorohydrin) chitosan matrices, which present diverse functional groups and may induce different adsorption mechanisms. X-ray photoelectron spectroscopy (XPS) revealed that these metals bind to glutaraldehyde-crosslinked chitosan, differently from the other two kinds of matrices. Hence, amino group availability and the formation of new structures such as imino bonds are key factors. Copper(II) stabilization was found to be poor in glutaraldehyde-crosslinked chitosan. Conversely, Hg(II) ions present higher adsorption capacity in this kind of matrix. Chromium(VI) was reduced in all three matrices. In this case, chromium(VI) is probably not well stabilized by the functional groups of these polymers and may also undergo the action of their reducing groups.001C01ICuivre; Mercure; Chrome; Adsorption; Chitosane; Film; Spectrométrie photoélectron; Rayon X; Mécanisme; Biopolymère; Métal lourd; Focalisation; Potentiel; Adsorbant; Complexe; Liaison; Polymère; Spectrométrie électron; Ion métallique; Ion chrome; Ion mercure; Groupe fonctionnel; Groupe aminé; Structure; Cuivre II; Stabilisation; Capacité adsorption; Chrome VIMétal transitionCopper; Mercury; Chromium; Adsorption; Chitosan; Film; Photoelectron spectrometry; X ray; Mechanism; Biopolymer; Heavy metal; Focusing; Potential; Adsorbent; Complexes; Binding; Polymer; Electron spectrometry; Metal ion; Chromium ion; Mercury ion; Functional group; Amino group; Structure; Copper II; Stabilization; Adsorption capacity; Chromium VITransition metalCobre; Mercurio; Cromo; Adsorción; Quitosano; Película; Espectrometría fotoelectrón; Rayos X; Mecanismo; Biopolímero; Metal pesado; Focalización; Potencial; Adsorbente; Complejo; Enlace; Polímero; Espectrometría electrón; Ión metálico; Cromo ión; Mercurio ión; Grupo funcional; Grupo aminado; Estructura; Cobre II; Estabilización; Capacidad adsorción; Cromo VIINIST-18274A.35400019433045016011-0128533 001649 Phase Equilibrium and Optimization Tools: Application for Enhanced Structured Lipids for FoodsMoises Teles Dos SantosEscola Politécnica, Laboratório de Simulação e Controle de Processos, Universidade de São Paulo, Av. Prof. Lineu PrestesSão Paulo 5088-900BRA1 aut.2 aut.INP, UPS, LGC (Laboratoire de Génie Chimique), Université de Toulouse, 4 allée Emile Monso31030 ToulouseFRA1 aut.3 aut.LGC (Laboratoire de Génie Chimique), CNRS31030 ToulouseFRA1 aut.Galo A. C. Le RouxEscola Politécnica, Laboratório de Simulação e Controle de Processos, Universidade de São Paulo, Av. Prof. Lineu PrestesSão Paulo 5088-900BRA1 aut.2 aut.Vincent GerbaudINP, UPS, LGC (Laboratoire de Génie Chimique), Université de Toulouse, 4 allée Emile Monso31030 ToulouseFRA1 aut.3 aut.11-01310522011PASCAL 11-0131052 INISTPascal:11-01310520012490003-021XJ. Am. Oil Chem. Soc.Journal of the American Oil Chemists' SocietyAcid mediumDifferential scanning calorimetryFat contentFatty acidsMedium chainMelting pointOils and fats industryOptimizationStructured lipidTriacylglycerolOptimisationLipide structuréTriacylglycérolCalorimétrie différentielle balayageTeneur matière grassePoint fusionChaîne moyenneMilieu acideAcide grasIndustrie corps gras
Solid-liquid phase equilibrium modeling of triacylglycerol mixtures is essential for lipids design. Considering the α polymorphism and liquid phase as ideal, the Margules 2-suffix excess Gibbs energy model with predictive binary parameter correlations describes the non ideal β and β' solid polymorphs. Solving by direct optimization of the Gibbs free energy enables one to predict from a bulk mixture composition the phases composition at a given temperature and thus the SFC curve, the melting profile and the Differential Scanning Calorimetry (DSC) curve that are related to end-user lipid properties. Phase diagram, SFC and DSC curve experimental data are qualitatively and quantitatively well predicted for the binary mixture 1,3-dipalmitoyl-2-oleoyl-sn-glycerol (POP) and 1,2,3-tripalmitoyl-sn-glycerol (PPP), the ternary mixture 1,3-dimyristoyl-2-palmitoyl-sn-glycerol (MPM), 1,2-distearoyl-3-oleoyl-sn-glycerol (SSO) and 1,2,3-trioleoyl-sn-glycerol (OOO), for palm oil and cocoa butter. Then, addition to palm oil of Medium-Long-Medium type structured lipids is evaluated, using caprylic acid as medium chain and long chain fatty acids (EPA-eicosapentaenoic acid, DHA-docosahexaenoic acid, γ-linolenic-octadecatrienoic acid and AA-arachidonic acid), as sn-2 substitutes. EPA, DHA and AA increase the melting range on both the fusion and crystallization side. γ-linolenic shifts the melting range upwards. This predictive tool is useful for the pre-screening of lipids matching desired properties set a priori.
0003-021XJ. Am. Oil Chem. Soc.882Phase Equilibrium and Optimization Tools: Application for Enhanced Structured Lipids for FoodsTELES DOS SANTOS (Moises)LE ROUX (Galo A. C.)GERBAUD (Vincent)Escola Politécnica, Laboratório de Simulação e Controle de Processos, Universidade de São Paulo, Av. Prof. Lineu PrestesSão Paulo 5088-900BRA1 aut.2 aut.INP, UPS, LGC (Laboratoire de Génie Chimique), Université de Toulouse, 4 allée Emile Monso31030 ToulouseFRA1 aut.3 aut.LGC (Laboratoire de Génie Chimique), CNRS31030 ToulouseFRA1 aut.223-2332011ENGINIST2043540001936676500600000© 2011 INIST-CNRS. All rights reserved.39 ref.11-0131052PAJournal of the American Oil Chemists' SocietyDEUSolid-liquid phase equilibrium modeling of triacylglycerol mixtures is essential for lipids design. Considering the α polymorphism and liquid phase as ideal, the Margules 2-suffix excess Gibbs energy model with predictive binary parameter correlations describes the non ideal β and β' solid polymorphs. Solving by direct optimization of the Gibbs free energy enables one to predict from a bulk mixture composition the phases composition at a given temperature and thus the SFC curve, the melting profile and the Differential Scanning Calorimetry (DSC) curve that are related to end-user lipid properties. Phase diagram, SFC and DSC curve experimental data are qualitatively and quantitatively well predicted for the binary mixture 1,3-dipalmitoyl-2-oleoyl-sn-glycerol (POP) and 1,2,3-tripalmitoyl-sn-glycerol (PPP), the ternary mixture 1,3-dimyristoyl-2-palmitoyl-sn-glycerol (MPM), 1,2-distearoyl-3-oleoyl-sn-glycerol (SSO) and 1,2,3-trioleoyl-sn-glycerol (OOO), for palm oil and cocoa butter. Then, addition to palm oil of Medium-Long-Medium type structured lipids is evaluated, using caprylic acid as medium chain and long chain fatty acids (EPA-eicosapentaenoic acid, DHA-docosahexaenoic acid, γ-linolenic-octadecatrienoic acid and AA-arachidonic acid), as sn-2 substitutes. EPA, DHA and AA increase the melting range on both the fusion and crystallization side. γ-linolenic shifts the melting range upwards. This predictive tool is useful for the pre-screening of lipids matching desired properties set a priori.002A35B08Optimisation01Optimization01Optimización01Lipide structuré02Structured lipid02Lipido estructurado02Triacylglycérol10Triacylglycerol10Triacilglicerol10Calorimétrie différentielle balayage19Differential scanning calorimetry19Análisis calorimétrico barrido exploración19Teneur matière grasse20Fat content20Contenido materia grasa20Point fusion24Melting point24Punto fusión24Chaîne moyenne26Medium chain26Cadena media26Milieu acide48Acid medium48Medio ácido48Acide gras53Fatty acids53Acido graso53Industrie corps gras63Oils and fats industry63Industria cuerpos grasos63087OTOOTOPASCAL 11-0131052 INISTPhase Equilibrium and Optimization Tools: Application for Enhanced Structured Lipids for FoodsTELES DOS SANTOS (Moises); LE ROUX (Galo A. C.); GERBAUD (Vincent)Escola Politécnica, Laboratório de Simulação e Controle de Processos, Universidade de São Paulo, Av. Prof. Lineu Prestes/São Paulo 5088-900/Brésil (1 aut., 2 aut.); INP, UPS, LGC (Laboratoire de Génie Chimique), Université de Toulouse, 4 allée Emile Monso/31030 Toulouse/France (1 aut., 3 aut.); LGC (Laboratoire de Génie Chimique), CNRS/31030 Toulouse/France (1 aut.)
Publication en série; Niveau analytique
Journal of the American Oil Chemists' Society; ISSN 0003-021X; Allemagne; Da. 2011; Vol. 88; No. 2; Pp. 223-233; Bibl. 39 ref.AnglaisSolid-liquid phase equilibrium modeling of triacylglycerol mixtures is essential for lipids design. Considering the α polymorphism and liquid phase as ideal, the Margules 2-suffix excess Gibbs energy model with predictive binary parameter correlations describes the non ideal β and β' solid polymorphs. Solving by direct optimization of the Gibbs free energy enables one to predict from a bulk mixture composition the phases composition at a given temperature and thus the SFC curve, the melting profile and the Differential Scanning Calorimetry (DSC) curve that are related to end-user lipid properties. Phase diagram, SFC and DSC curve experimental data are qualitatively and quantitatively well predicted for the binary mixture 1,3-dipalmitoyl-2-oleoyl-sn-glycerol (POP) and 1,2,3-tripalmitoyl-sn-glycerol (PPP), the ternary mixture 1,3-dimyristoyl-2-palmitoyl-sn-glycerol (MPM), 1,2-distearoyl-3-oleoyl-sn-glycerol (SSO) and 1,2,3-trioleoyl-sn-glycerol (OOO), for palm oil and cocoa butter. Then, addition to palm oil of Medium-Long-Medium type structured lipids is evaluated, using caprylic acid as medium chain and long chain fatty acids (EPA-eicosapentaenoic acid, DHA-docosahexaenoic acid, γ-linolenic-octadecatrienoic acid and AA-arachidonic acid), as sn-2 substitutes. EPA, DHA and AA increase the melting range on both the fusion and crystallization side. γ-linolenic shifts the melting range upwards. This predictive tool is useful for the pre-screening of lipids matching desired properties set a priori.002A35B08Optimisation; Lipide structuré; Triacylglycérol; Calorimétrie différentielle balayage; Teneur matière grasse; Point fusion; Chaîne moyenne; Milieu acide; Acide gras; Industrie corps grasOptimization; Structured lipid; Triacylglycerol; Differential scanning calorimetry; Fat content; Melting point; Medium chain; Acid medium; Fatty acids; Oils and fats industryOptimización; Lipido estructurado; Triacilglicerol; Análisis calorimétrico barrido exploración; Contenido materia grasa; Punto fusión; Cadena media; Medio ácido; Acido graso; Industria cuerpos grasosINIST-204.35400019366765006011-0131052 001650 Inhibitory effect of ursolic acid derivatives on hydrogen peroxide-and glutathione-mediated degradation of hemin: A possible additional mechanism of action for antimalarial activityCatherine MullieLaboratoire des Glucides - UMR CNRS 6219, Faculté de Pharmacie, 1, rue des Louvels80037AmienxFRA1 aut.2 aut.3 aut.5 aut.Alexia JonetLaboratoire des Glucides - UMR CNRS 6219, Faculté de Pharmacie, 1, rue des Louvels80037AmienxFRA1 aut.2 aut.3 aut.5 aut.Alexandra Dassonville-KlimptLaboratoire des Glucides - UMR CNRS 6219, Faculté de Pharmacie, 1, rue des Louvels80037AmienxFRA1 aut.2 aut.3 aut.5 aut.Grace GosmannFaculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. lpiranga, 2752Porto Alegre 90610-000, RSBRA4 aut.Pascal SonnetLaboratoire des Glucides - UMR CNRS 6219, Faculté de Pharmacie, 1, rue des Louvels80037AmienxFRA1 aut.2 aut.3 aut.5 aut.11-01312772010PASCAL 11-0131277 INISTPascal:11-01312770012480014-4894Exp. parasitol.Experimental parasitologyActivityAntimalarialBiological markerGlutathioneHydrogenMalariaMechanism of actionParasitePeroxidesPlasmodium falciparumHydrogènePeroxydeGlutathionMarqueur biologiqueMécanisme actionAntipaludiqueActivitéPaludismeParasitePlasmodium falciparum
Compounds obtained by the condensation of ursolic acid (UA) with 1,4-bis(3-aminopropyl)piperazines have previously been shown as cytocidal to Plasmodium falciparum strains. Preliminary results indicated that the inhibition of β-hematin formation (one of the possible mechanisms of action of antimalarial drugs) was achieved by a few of these molecules with varying efficiencies. To gain further insight in the antimalarial action of UA derivatives, we report here the results of additional pathways that may explain their in vitro cytocidal activity such as inhibition of hemin degradation by H2O2 or glutathione (GSH). H2O2-mediated hemin degradation was drastically reduced by hydroxybenzyl-substituted UA derivatives while UA and intermediate compounds displayed weaker inhibitory actions. The results of GSH-mediated hemin degradation inhibition did not parallel those of H2O2 degradation as hydroxybenzyl-substituted UA only proved to be a weak inhibitor. As H2O2 interaction with the iron moiety of hemin is the first step towards its degradation, we assume that the interaction of our products with the ferric ion in the hemin structure is of upmost importance in inhibiting its peroxidative degradation. A two-step mechanism of action implying (1) stacking of the acetylursolic acid structure to hemin and (2) additive protection of hemin ferric iron from H2O2 by hydroxyphenyl groups through steric hindrance and/or trapping of oxygen reactive species in the direct neighborhood of ferric iron can be put forward. For GSH degradation pathway, grafting of UA structure with a piperazine structure gave the best inhibition, pleading for the implication of this latter moiety in the inhibitory process.
0014-4894EXPAAAExp. parasitol.1253Inhibitory effect of ursolic acid derivatives on hydrogen peroxide-and glutathione-mediated degradation of hemin: A possible additional mechanism of action for antimalarial activityMULLIE (Catherine)JONET (Alexia)DASSONVILLE-KLIMPT (Alexandra)GOSMANN (Grace)SONNET (Pascal)Laboratoire des Glucides - UMR CNRS 6219, Faculté de Pharmacie, 1, rue des Louvels80037AmienxFRA1 aut.2 aut.3 aut.5 aut.Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. lpiranga, 2752Porto Alegre 90610-000, RSBRA4 aut.202-2072010ENGINIST71943540001936730000300000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0131277PAExperimental parasitologyNLDCompounds obtained by the condensation of ursolic acid (UA) with 1,4-bis(3-aminopropyl)piperazines have previously been shown as cytocidal to Plasmodium falciparum strains. Preliminary results indicated that the inhibition of β-hematin formation (one of the possible mechanisms of action of antimalarial drugs) was achieved by a few of these molecules with varying efficiencies. To gain further insight in the antimalarial action of UA derivatives, we report here the results of additional pathways that may explain their in vitro cytocidal activity such as inhibition of hemin degradation by H2O2 or glutathione (GSH). H2O2-mediated hemin degradation was drastically reduced by hydroxybenzyl-substituted UA derivatives while UA and intermediate compounds displayed weaker inhibitory actions. The results of GSH-mediated hemin degradation inhibition did not parallel those of H2O2 degradation as hydroxybenzyl-substituted UA only proved to be a weak inhibitor. As H2O2 interaction with the iron moiety of hemin is the first step towards its degradation, we assume that the interaction of our products with the ferric ion in the hemin structure is of upmost importance in inhibiting its peroxidative degradation. A two-step mechanism of action implying (1) stacking of the acetylursolic acid structure to hemin and (2) additive protection of hemin ferric iron from H2O2 by hydroxyphenyl groups through steric hindrance and/or trapping of oxygen reactive species in the direct neighborhood of ferric iron can be put forward. For GSH degradation pathway, grafting of UA structure with a piperazine structure gave the best inhibition, pleading for the implication of this latter moiety in the inhibitory process.002A11D002A14D05B002B05E02B4HydrogèneNC01HydrogenNC01HidrógenoNC01PeroxydeNA02PeroxidesNA02PeróxidoNA02Glutathion03Glutathione03Glutatión03Marqueur biologique04Biological marker04Marcador biológico04Mécanisme action05Mechanism of action05Mecanismo acción05Antipaludique06Antimalarial06Antipalúdico06Activité07Activity07Actividad07Paludisme08Malaria08Paludismo08Parasite09Parasite09Parásito09Plasmodium falciparumNS55Plasmodium falciparumNS55Plasmodium falciparumNS55ProtozooseProtozoal diseaseProtozoosisParasitoseParasitosisParasitosisInfectionInfectionInfecciónApicomplexaNSApicomplexaNSApicomplexaNSProtozoaNSProtozoaNSProtozoaNS087OTOOTOPASCAL 11-0131277 INISTInhibitory effect of ursolic acid derivatives on hydrogen peroxide-and glutathione-mediated degradation of hemin: A possible additional mechanism of action for antimalarial activityMULLIE (Catherine); JONET (Alexia); DASSONVILLE-KLIMPT (Alexandra); GOSMANN (Grace); SONNET (Pascal)Laboratoire des Glucides - UMR CNRS 6219, Faculté de Pharmacie, 1, rue des Louvels/80037Amienx/France (1 aut., 2 aut., 3 aut., 5 aut.); Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. lpiranga, 2752/Porto Alegre 90610-000, RS/Brésil (4 aut.)
Publication en série; Niveau analytique
Experimental parasitology; ISSN 0014-4894; Coden EXPAAA; Pays-Bas; Da. 2010; Vol. 125; No. 3; Pp. 202-207; Bibl. 3/4 p.AnglaisCompounds obtained by the condensation of ursolic acid (UA) with 1,4-bis(3-aminopropyl)piperazines have previously been shown as cytocidal to Plasmodium falciparum strains. Preliminary results indicated that the inhibition of β-hematin formation (one of the possible mechanisms of action of antimalarial drugs) was achieved by a few of these molecules with varying efficiencies. To gain further insight in the antimalarial action of UA derivatives, we report here the results of additional pathways that may explain their in vitro cytocidal activity such as inhibition of hemin degradation by H2O2 or glutathione (GSH). H2O2-mediated hemin degradation was drastically reduced by hydroxybenzyl-substituted UA derivatives while UA and intermediate compounds displayed weaker inhibitory actions. The results of GSH-mediated hemin degradation inhibition did not parallel those of H2O2 degradation as hydroxybenzyl-substituted UA only proved to be a weak inhibitor. As H2O2 interaction with the iron moiety of hemin is the first step towards its degradation, we assume that the interaction of our products with the ferric ion in the hemin structure is of upmost importance in inhibiting its peroxidative degradation. A two-step mechanism of action implying (1) stacking of the acetylursolic acid structure to hemin and (2) additive protection of hemin ferric iron from H2O2 by hydroxyphenyl groups through steric hindrance and/or trapping of oxygen reactive species in the direct neighborhood of ferric iron can be put forward. For GSH degradation pathway, grafting of UA structure with a piperazine structure gave the best inhibition, pleading for the implication of this latter moiety in the inhibitory process.002A11D; 002A14D05B; 002B05E02B4Hydrogène; Peroxyde; Glutathion; Marqueur biologique; Mécanisme action; Antipaludique; Activité; Paludisme; Parasite; Plasmodium falciparumProtozoose; Parasitose; Infection; Apicomplexa; ProtozoaHydrogen; Peroxides; Glutathione; Biological marker; Mechanism of action; Antimalarial; Activity; Malaria; Parasite; Plasmodium falciparumProtozoal disease; Parasitosis; Infection; Apicomplexa; ProtozoaHidrógeno; Peróxido; Glutatión; Marcador biológico; Mecanismo acción; Antipalúdico; Actividad; Paludismo; Parásito; Plasmodium falciparumINIST-7194.35400019367300003011-0131277 001651 Decreased insulin secretion and increased risk of type 2 diabetes associated with allelic variations of the WFS1 gene: the Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) prospective studyN. CheurfaINSERM, Research Unit 695, 16 rue Henri Huchard75018 ParisFRA1 aut.2 aut.5 aut.9 aut.11 aut.12 aut.G. M. BrennerINSERM, Research Unit 695, 16 rue Henri Huchard75018 ParisFRA1 aut.2 aut.5 aut.9 aut.11 aut.12 aut.Post-Graduation Program in Health Sciences, Federal University of Health Sciences of Porto AlegrePorto AlegreBRA2 aut.A. F. ReisLaboratory of Molecular Endocrinology, Federal University of São PauloSão PauloBRA3 aut.D. Dubois-LaforgueDepartment of Immunology and Diabetology, Assistance Publique H6pitaux de Paris - Cochin HospitalParisFRA4 aut.10 aut.UFR de Médecine, Université Paris Descartes (Paris 5ParisFRA4 aut.6 aut.R. RousselINSERM, Research Unit 695, 16 rue Henri Huchard75018 ParisFRA1 aut.2 aut.5 aut.9 aut.11 aut.12 aut.UFR de Médecine, Université Paris Diderot (Paris 7)ParisFRA5 aut.9 aut.11 aut.Department of Diabetology, Endocrinology and Nutrition, Assistance Publique Hôpitaux de Paris - Bichat HospitalParisFRA5 aut.11 aut.J. TichetUFR de Médecine, Université Paris Descartes (Paris 5ParisFRA4 aut.6 aut.Institut Inter Régional pour la Santé (IRSA)La RicheFRA6 aut.7 aut.O. LantieriInstitut Inter Régional pour la Santé (IRSA)La RicheFRA6 aut.7 aut.B. BalkauINSERM, U1018, CESP Centre for research in Epidemiology and Population HealthU1018 VillejuifFRA8 aut.UMRS 1018, Université Paris Sud (Paris 11)VillejuifFRA8 aut.F. FumeronINSERM, Research Unit 695, 16 rue Henri Huchard75018 ParisFRA1 aut.2 aut.5 aut.9 aut.11 aut.12 aut.UFR de Médecine, Université Paris Diderot (Paris 7)ParisFRA5 aut.9 aut.11 aut.J. TimsitDepartment of Immunology and Diabetology, Assistance Publique H6pitaux de Paris - Cochin HospitalParisFRA4 aut.10 aut.M. MarreINSERM, Research Unit 695, 16 rue Henri Huchard75018 ParisFRA1 aut.2 aut.5 aut.9 aut.11 aut.12 aut.UFR de Médecine, Université Paris Diderot (Paris 7)ParisFRA5 aut.9 aut.11 aut.Department of Diabetology, Endocrinology and Nutrition, Assistance Publique Hôpitaux de Paris - Bichat HospitalParisFRA5 aut.11 aut.G. VelhoINSERM, Research Unit 695, 16 rue Henri Huchard75018 ParisFRA1 aut.2 aut.5 aut.9 aut.11 aut.12 aut.11-01318022011PASCAL 11-0131802 INISTPascal:11-01318020012470012-186XDiabetologia : (Berl.)Diabetologia : (Berlin)Endoplasmic reticulumEpidemiologyGeneGeneticsInsulinInsulin resistanceProspectiveRisk factorSecretionStressType 2 diabetesInsulineSécrétionFacteur risqueGèneProspectiveRéticulum endoplasmiqueDiabète de type 2InsulinorésistanceStressGénétiqueEpidémiologie
Aims/hypothesis We investigated associations of allelic variations in the WFS1 gene with insulin secretion and risk of type 2 diabetes in a general population prospective study. Methods We studied 5,110 unrelated French men and women who participated in the prospective Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Additional cross-sectional analyses were performed on 4,472 French individuals with type 2 diabetes and 3,065 controls. Three single nucleotide polymorphisms (SNPs) were genotyped: rs10010131, rs1801213/rs7672995 and rs734312. Results We observed statistically significant associations between the major alleles of the three variants and prevalent type 2 diabetes in the DESIR cohort at baseline. Cox analyses showed an association between the G-allele of rs10010131 and incident type 2 diabetes (HR 1.34, 95% CI 1.08-1.70, p=0.007). Similar results were observed for the G-allele of rs 1801213 and the A-allele of rs734312. The GGA haplotype was associated with an increased risk of diabetes as compared with the ACG haplotype (HR 1.26, 95% CI 1.04-1.42, p=0.02). We also observed statistically significant associations of the three SNPs with plasma glucose, HbA1c levels and insulin secretion at baseline and throughout the study in individuals with type 2 diabetes or at risk of developing diabetes. However, no association was observed in those who remained normoglycaemic at the end of the follow-up. Associations between the three variants and type 2 diabetes were replicated in cross-sectional studies of type 2 diabetic patients in comparison with a non-diabetic control group. Conclusions/interpretation The most frequent haplotype at the haplotype block containing the WFSI gene modulated insulin secretion and was associated with an increased risk of type 2 diabetes.
0012-186XDiabetologia : (Berl.)543Decreased insulin secretion and increased risk of type 2 diabetes associated with allelic variations of the WFS1 gene: the Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) prospective studyCHEURFA (N.)BRENNER (G. M.)REIS (A. F.)DUBOIS-LAFORGUE (D.)ROUSSEL (R.)TICHET (J.)LANTIERI (O.)BALKAU (B.)FUMERON (F.)TIMSIT (J.)MARRE (M.)VELHO (G.)INSERM, Research Unit 695, 16 rue Henri Huchard75018 ParisFRA1 aut.2 aut.5 aut.9 aut.11 aut.12 aut.Post-Graduation Program in Health Sciences, Federal University of Health Sciences of Porto AlegrePorto AlegreBRA2 aut.Laboratory of Molecular Endocrinology, Federal University of São PauloSão PauloBRA3 aut.Department of Immunology and Diabetology, Assistance Publique H6pitaux de Paris - Cochin HospitalParisFRA4 aut.10 aut.UFR de Médecine, Université Paris Descartes (Paris 5ParisFRA4 aut.6 aut.UFR de Médecine, Université Paris Diderot (Paris 7)ParisFRA5 aut.9 aut.11 aut.Department of Diabetology, Endocrinology and Nutrition, Assistance Publique Hôpitaux de Paris - Bichat HospitalParisFRA5 aut.11 aut.Institut Inter Régional pour la Santé (IRSA)La RicheFRA6 aut.7 aut.INSERM, U1018, CESP Centre for research in Epidemiology and Population HealthU1018 VillejuifFRA8 aut.UMRS 1018, Université Paris Sud (Paris 11)VillejuifFRA8 aut.554-5622011ENGINIST130123540001943975201300000© 2011 INIST-CNRS. All rights reserved.33 ref.11-0131802PADiabetologia : (Berlin)DEUAims/hypothesis We investigated associations of allelic variations in the WFS1 gene with insulin secretion and risk of type 2 diabetes in a general population prospective study. Methods We studied 5,110 unrelated French men and women who participated in the prospective Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Additional cross-sectional analyses were performed on 4,472 French individuals with type 2 diabetes and 3,065 controls. Three single nucleotide polymorphisms (SNPs) were genotyped: rs10010131, rs1801213/rs7672995 and rs734312. Results We observed statistically significant associations between the major alleles of the three variants and prevalent type 2 diabetes in the DESIR cohort at baseline. Cox analyses showed an association between the G-allele of rs10010131 and incident type 2 diabetes (HR 1.34, 95% CI 1.08-1.70, p=0.007). Similar results were observed for the G-allele of rs 1801213 and the A-allele of rs734312. The GGA haplotype was associated with an increased risk of diabetes as compared with the ACG haplotype (HR 1.26, 95% CI 1.04-1.42, p=0.02). We also observed statistically significant associations of the three SNPs with plasma glucose, HbA1c levels and insulin secretion at baseline and throughout the study in individuals with type 2 diabetes or at risk of developing diabetes. However, no association was observed in those who remained normoglycaemic at the end of the follow-up. Associations between the three variants and type 2 diabetes were replicated in cross-sectional studies of type 2 diabetic patients in comparison with a non-diabetic control group. Conclusions/interpretation The most frequent haplotype at the haplotype block containing the WFSI gene modulated insulin secretion and was associated with an increased risk of type 2 diabetes.002B21E01AInsuline01Insulin01Insulina01Sécrétion02Secretion02Secreción02Facteur risque03Risk factor03Factor riesgo03Gène04Gene04Gen04Prospective07Prospective07Prospectiva07Réticulum endoplasmique08Endoplasmic reticulum08Retículo endoplásmico08Diabète de type 2NM09Type 2 diabetesNM09Diabetes de tipo 2NM09InsulinorésistanceNM12Insulin resistanceNM12Resistancia insulinaNM12Stress13Stress13Estrés13Génétique14Genetics14Genética14Epidémiologie15Epidemiology15Epidemiología15Hormone pancréatique20Pancreatic hormone20Hormona pancreática20Endocrinopathie21Endocrinopathy21Endocrinopatía21Maladie métabolique22Metabolic diseases22Metabolismo patología22Résistance tissu cible23Target tissue resistance23Resistencia tejido blanco23087OTOOTOPASCAL 11-0131802 INISTDecreased insulin secretion and increased risk of type 2 diabetes associated with allelic variations of the WFS1 gene: the Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) prospective studyCHEURFA (N.); BRENNER (G. M.); REIS (A. F.); DUBOIS-LAFORGUE (D.); ROUSSEL (R.); TICHET (J.); LANTIERI (O.); BALKAU (B.); FUMERON (F.); TIMSIT (J.); MARRE (M.); VELHO (G.)INSERM, Research Unit 695, 16 rue Henri Huchard/75018 Paris/France (1 aut., 2 aut., 5 aut., 9 aut., 11 aut., 12 aut.); Post-Graduation Program in Health Sciences, Federal University of Health Sciences of Porto Alegre/Porto Alegre/Brésil (2 aut.); Laboratory of Molecular Endocrinology, Federal University of São Paulo/São Paulo/Brésil (3 aut.); Department of Immunology and Diabetology, Assistance Publique H6pitaux de Paris - Cochin Hospital/Paris/France (4 aut., 10 aut.); UFR de Médecine, Université Paris Descartes (Paris 5/Paris/France (4 aut., 6 aut.); UFR de Médecine, Université Paris Diderot (Paris 7)/Paris/France (5 aut., 9 aut., 11 aut.); Department of Diabetology, Endocrinology and Nutrition, Assistance Publique Hôpitaux de Paris - Bichat Hospital/Paris/France (5 aut., 11 aut.); Institut Inter Régional pour la Santé (IRSA)/La Riche/France (6 aut., 7 aut.); INSERM, U1018, CESP Centre for research in Epidemiology and Population Health/U1018 Villejuif/France (8 aut.); UMRS 1018, Université Paris Sud (Paris 11)/Villejuif/France (8 aut.)
Publication en série; Niveau analytique
Diabetologia : (Berlin); ISSN 0012-186X; Allemagne; Da. 2011; Vol. 54; No. 3; Pp. 554-562; Bibl. 33 ref.AnglaisAims/hypothesis We investigated associations of allelic variations in the WFS1 gene with insulin secretion and risk of type 2 diabetes in a general population prospective study. Methods We studied 5,110 unrelated French men and women who participated in the prospective Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Additional cross-sectional analyses were performed on 4,472 French individuals with type 2 diabetes and 3,065 controls. Three single nucleotide polymorphisms (SNPs) were genotyped: rs10010131, rs1801213/rs7672995 and rs734312. Results We observed statistically significant associations between the major alleles of the three variants and prevalent type 2 diabetes in the DESIR cohort at baseline. Cox analyses showed an association between the G-allele of rs10010131 and incident type 2 diabetes (HR 1.34, 95% CI 1.08-1.70, p=0.007). Similar results were observed for the G-allele of rs 1801213 and the A-allele of rs734312. The GGA haplotype was associated with an increased risk of diabetes as compared with the ACG haplotype (HR 1.26, 95% CI 1.04-1.42, p=0.02). We also observed statistically significant associations of the three SNPs with plasma glucose, HbA1c levels and insulin secretion at baseline and throughout the study in individuals with type 2 diabetes or at risk of developing diabetes. However, no association was observed in those who remained normoglycaemic at the end of the follow-up. Associations between the three variants and type 2 diabetes were replicated in cross-sectional studies of type 2 diabetic patients in comparison with a non-diabetic control group. Conclusions/interpretation The most frequent haplotype at the haplotype block containing the WFSI gene modulated insulin secretion and was associated with an increased risk of type 2 diabetes.002B21E01AInsuline; Sécrétion; Facteur risque; Gène; Prospective; Réticulum endoplasmique; Diabète de type 2; Insulinorésistance; Stress; Génétique; EpidémiologieHormone pancréatique; Endocrinopathie; Maladie métabolique; Résistance tissu cibleInsulin; Secretion; Risk factor; Gene; Prospective; Endoplasmic reticulum; Type 2 diabetes; Insulin resistance; Stress; Genetics; EpidemiologyPancreatic hormone; Endocrinopathy; Metabolic diseases; Target tissue resistanceInsulina; Secreción; Factor riesgo; Gen; Prospectiva; Retículo endoplásmico; Diabetes de tipo 2; Resistancia insulina; Estrés; Genética; EpidemiologíaINIST-13012.35400019439752013011-0131802 001652 AVERAGE CONTINUOUS CONTROL OF PIECEWISE DETERMINISTIC MARKOV PROCESSESO. L. V. CostaDepartamento de Engenharia de Telecomunicações e Controle, Escola Politécnica da Universidade de São PauloCEP 05508-900, São Paulo, S.P.BRA1 aut.F. DufourInstitut de Mathimatiques de Bordeaux and INRIA Bordeaux Sud Ouest, Team CQFD, Université Bordeaux 1, 351 cours de la Libération33405 TalenceFRA2 aut.11-01333772010PASCAL 11-0133377 INISTPascal:11-01333770012460363-0129SIAM j. control optim.SIAM journal on control and optimizationAverage costBorel spaceCompact spaceContinuous controlContinuous timeDifferential equationDiscrete timeExistence conditionExistence of solutionExistence theoremFeedbackFeedback regulationIntegrodifferential equationJump processLocalizationLong termMarkov chainMarkov processModelingOptimal controlVanishing discountContrôle continuProcessus MarkovTemps continuCoût moyenLong termeEspace BorelEspace compactProcessus sautTemps discretChaîne MarkovLocalisationThéorème existenceRétroactionBoucle réactionEquation intégrodifférentielleEquation différentielleCondition existenceModélisationExistence solutionCommande optimaleActualisation évanescente
This paper deals with the long run average continuous control problem of piecewise deterministic Markov processes (PDMPs) taking values in a general Borel space and with compact action space depending on the state variable. The control variable acts on the jump rate and transition measure of the PDMP, and the running and boundary costs are assumed to be positive but not necessarily bounded. Our first main result is to obtain an optimality equation for the long run average cost in terms of a discrete-time optimality equation related to the embedded Markov chain given by the postjump location of the PDMP. Our second main result guarantees the existence of a feedback measurable selector for the discrete-time optimality equation by establishing a connection between this equation and an integro-differential equation. Our final main result is to obtain some sufficient conditions for the existence of a solution for a discrete-time optimality inequality and an ordinary optimal feedback control for the long run average cost using the so-called vanishing discount approach. Two examples are presented illustrating the possible applications of the results developed in the paper.
0363-0129SJCODCSIAM j. control optim.487-8AVERAGE CONTINUOUS CONTROL OF PIECEWISE DETERMINISTIC MARKOV PROCESSESCOSTA (O. L. V.)DUFOUR (F.)Departamento de Engenharia de Telecomunicações e Controle, Escola Politécnica da Universidade de São PauloCEP 05508-900, São Paulo, S.P.BRA1 aut.Institut de Mathimatiques de Bordeaux and INRIA Bordeaux Sud Ouest, Team CQFD, Université Bordeaux 1, 351 cours de la Libération33405 TalenceFRA2 aut.4262-42912010ENGINIST4588B3540001936502300400000© 2011 INIST-CNRS. All rights reserved.39 ref.11-0133377PASIAM journal on control and optimizationUSAThis paper deals with the long run average continuous control problem of piecewise deterministic Markov processes (PDMPs) taking values in a general Borel space and with compact action space depending on the state variable. The control variable acts on the jump rate and transition measure of the PDMP, and the running and boundary costs are assumed to be positive but not necessarily bounded. Our first main result is to obtain an optimality equation for the long run average cost in terms of a discrete-time optimality equation related to the embedded Markov chain given by the postjump location of the PDMP. Our second main result guarantees the existence of a feedback measurable selector for the discrete-time optimality equation by establishing a connection between this equation and an integro-differential equation. Our final main result is to obtain some sufficient conditions for the existence of a solution for a discrete-time optimality inequality and an ordinary optimal feedback control for the long run average cost using the so-called vanishing discount approach. Two examples are presented illustrating the possible applications of the results developed in the paper.001A02H01JContrôle continu06Continuous control06Control continuo06Processus Markov07Markov process07Proceso Markov07Temps continu08Continuous time08Tiempo continuo08Coût moyen09Average cost09Coste medio09Long terme10Long term10Largo plazo10Espace Borel11Borel space11Espacio Borel11Espace compact12Compact space12Espacio compacto12Processus saut13Jump process13Proceso salto13Temps discret14Discrete time14Tiempo discreto14Chaîne Markov15Markov chain15Cadena Markov15Localisation16Localization16Localización16Théorème existence17Existence theorem17Teorema existencia17Rétroaction18Feedback regulation18Retroacción18Boucle réaction19Feedback19Retroalimentación19Equation intégrodifférentielle20Integrodifferential equation20Ecuación integrodiferencial20Equation différentielle21Differential equation21Ecuación diferencial21Condition existence22Existence condition22Condición existencia22Modélisation23Modeling23Modelización23Existence solution24Existence of solution24Existencia de solución24Commande optimale25Optimal control25Control óptimo25Actualisation évanescenteCD96Vanishing discountCD96Actualización evanescenteCD96087OTOOTOPASCAL 11-0133377 INISTAVERAGE CONTINUOUS CONTROL OF PIECEWISE DETERMINISTIC MARKOV PROCESSESCOSTA (O. L. V.); DUFOUR (F.)Departamento de Engenharia de Telecomunicações e Controle, Escola Politécnica da Universidade de São Paulo/CEP 05508-900, São Paulo, S.P./Brésil (1 aut.); Institut de Mathimatiques de Bordeaux and INRIA Bordeaux Sud Ouest, Team CQFD, Université Bordeaux 1, 351 cours de la Libération/33405 Talence/France (2 aut.)
Publication en série; Niveau analytique
SIAM journal on control and optimization; ISSN 0363-0129; Coden SJCODC; Etats-Unis; Da. 2010; Vol. 48; No. 7-8; Pp. 4262-4291; Bibl. 39 ref.AnglaisThis paper deals with the long run average continuous control problem of piecewise deterministic Markov processes (PDMPs) taking values in a general Borel space and with compact action space depending on the state variable. The control variable acts on the jump rate and transition measure of the PDMP, and the running and boundary costs are assumed to be positive but not necessarily bounded. Our first main result is to obtain an optimality equation for the long run average cost in terms of a discrete-time optimality equation related to the embedded Markov chain given by the postjump location of the PDMP. Our second main result guarantees the existence of a feedback measurable selector for the discrete-time optimality equation by establishing a connection between this equation and an integro-differential equation. Our final main result is to obtain some sufficient conditions for the existence of a solution for a discrete-time optimality inequality and an ordinary optimal feedback control for the long run average cost using the so-called vanishing discount approach. Two examples are presented illustrating the possible applications of the results developed in the paper.001A02H01JContrôle continu; Processus Markov; Temps continu; Coût moyen; Long terme; Espace Borel; Espace compact; Processus saut; Temps discret; Chaîne Markov; Localisation; Théorème existence; Rétroaction; Boucle réaction; Equation intégrodifférentielle; Equation différentielle; Condition existence; Modélisation; Existence solution; Commande optimale; Actualisation évanescenteContinuous control; Markov process; Continuous time; Average cost; Long term; Borel space; Compact space; Jump process; Discrete time; Markov chain; Localization; Existence theorem; Feedback regulation; Feedback; Integrodifferential equation; Differential equation; Existence condition; Modeling; Existence of solution; Optimal control; Vanishing discountControl continuo; Proceso Markov; Tiempo continuo; Coste medio; Largo plazo; Espacio Borel; Espacio compacto; Proceso salto; Tiempo discreto; Cadena Markov; Localización; Teorema existencia; Retroacción; Retroalimentación; Ecuación integrodiferencial; Ecuación diferencial; Condición existencia; Modelización; Existencia de solución; Control óptimo; Actualización evanescenteINIST-4588B.35400019365023004011-0133377 001653 Design and rationale of the Radial Vs. femorAL access for coronary intervention (RIVAL) trial: A randomized comparison of radial versus femoral access for coronary angiography or intervention in patients with acute coronary syndromesSanjit S. JollyMcMaster University and the Population Health Research Institute, Hamilton Health SciencesHamilton, OntarioCAN1 aut.12 aut.13 aut.14 aut.Kari NiemelTampere University HospitalTampereFIN2 aut.Denis XavierSt John's Medical College and Research InstituteBangaloreIND3 aut.Petr WidimskyCharles University, Hospital Kralovske VinohradyPragueCZE4 aut.Andrzej BudajPostgraduate Medical School, Department of Cardiology, Grochowski HospitalWarsawPOL5 aut.Vicent ValentinHospital Universitari Dr PesetValenciaESP6 aut.Basil S. LewisLady Davis Carmel Medical CenterHaifaISR7 aut.Alvaro AvezumDante Pazzanese Institute of CardiologySao PauloBRA8 aut.Philippe Gabriel StegINSERM U-698. "Recherche Clinique en Athérothrombose." Université Paris 7 and Assistance Publique-Hôpitaux de ParisParisFRA9 aut.Sunil V. RaoDuke Clinical Research Institute, Duke UniversityDurham, North CarolinaUSA10 aut.John CairnsUniversity of British ColumbiaVancouverCAN11 aut.Susan ChrolaviciusMcMaster University and the Population Health Research Institute, Hamilton Health SciencesHamilton, OntarioCAN1 aut.12 aut.13 aut.14 aut.Salim YusufMcMaster University and the Population Health Research Institute, Hamilton Health SciencesHamilton, OntarioCAN1 aut.12 aut.13 aut.14 aut.Shamir R. MehtaMcMaster University and the Population Health Research Institute, Hamilton Health SciencesHamilton, OntarioCAN1 aut.12 aut.13 aut.14 aut.11-01336262011PASCAL 11-0133626 INISTPascal:11-01336260012450002-8703Am. heart j.The American heart journalAccessibilityAcute coronary syndromeCardiologyCardiovascular diseaseCirculatory systemComparative studyCoronary arteriographyCoronary arteryCoronary heart diseaseDesignFemurHumanPatientRandomizationCardiopathie coronairePathologie de l'appareil circulatoireConceptionEtude comparativeFémurAccessibilitéArtère coronaireRandomisationCoronarographieHommeMaladeAppareil circulatoireCardiologieSyndrome coronaire aigu
Background Major bleeding in acute coronary syndromes (ACS) is associated with an increased risk of subsequent mortality and recurrent ischemic events. Observational data and small randomized trials suggest that radial instead of femoral access for coronary angiography/intervention results in fewer bleeding complications, with preserved and possibly improved efficacy. Radial access versus femoral access has yet to be formally evaluated in a randomized trial adequately powered for the comparison of clinically important outcomes. Objectives The aim of this study is to evaluate the efficacy and safety of radial versus femoral access for coronary angiography/intervention in patients with ACS managed with an invasive strategy. Design This was a multicenter international randomized trial with blinded assessment of outcomes. 7021 patients with ACS (with or without ST elevation) have been randomized to either radial or femoral access for coronary angiography/intervention. The primary outcome is the composite of death, myocardial infarction, stroke, or non-coronary artery bypass graft-related major bleeding up to day 30. The key secondary outcomes are (1) death, myocardial infarction, or stroke up to day 30 and (2) non-coronary artery bypass graft-related major bleeding up to day 30. Percutaneous coronary intervention (PCI) success rates will also be compared between the two access sites. Conclusions The RIVAL trial will help define the optimal access site for coronary angiography/intervention in patients with ACS.
0002-8703AHJOA2Am. heart j.1612Design and rationale of the Radial Vs. femorAL access for coronary intervention (RIVAL) trial: A randomized comparison of radial versus femoral access for coronary angiography or intervention in patients with acute coronary syndromesJOLLY (Sanjit S.)NIEMELÄ (Kari)XAVIER (Denis)WIDIMSKY (Petr)BUDAJ (Andrzej)VALENTIN (Vicent)LEWIS (Basil S.)AVEZUM (Alvaro)STEG (Philippe Gabriel)RAO (Sunil V.)CAIRNS (John)CHROLAVICIUS (Susan)YUSUF (Salim)MEHTA (Shamir R.)McMaster University and the Population Health Research Institute, Hamilton Health SciencesHamilton, OntarioCAN1 aut.12 aut.13 aut.14 aut.Tampere University HospitalTampereFIN2 aut.St John's Medical College and Research InstituteBangaloreIND3 aut.Charles University, Hospital Kralovske VinohradyPragueCZE4 aut.Postgraduate Medical School, Department of Cardiology, Grochowski HospitalWarsawPOL5 aut.Hospital Universitari Dr PesetValenciaESP6 aut.Lady Davis Carmel Medical CenterHaifaISR7 aut.Dante Pazzanese Institute of CardiologySao PauloBRA8 aut.INSERM U-698. "Recherche Clinique en Athérothrombose." Université Paris 7 and Assistance Publique-Hôpitaux de ParisParisFRA9 aut.Duke Clinical Research Institute, Duke UniversityDurham, North CarolinaUSA10 aut.University of British ColumbiaVancouverCAN11 aut.254-2602011ENGINIST20573540001920206900600000© 2011 INIST-CNRS. All rights reserved.23 ref.11-0133626PAThe American heart journalUSABackground Major bleeding in acute coronary syndromes (ACS) is associated with an increased risk of subsequent mortality and recurrent ischemic events. Observational data and small randomized trials suggest that radial instead of femoral access for coronary angiography/intervention results in fewer bleeding complications, with preserved and possibly improved efficacy. Radial access versus femoral access has yet to be formally evaluated in a randomized trial adequately powered for the comparison of clinically important outcomes. Objectives The aim of this study is to evaluate the efficacy and safety of radial versus femoral access for coronary angiography/intervention in patients with ACS managed with an invasive strategy. Design This was a multicenter international randomized trial with blinded assessment of outcomes. 7021 patients with ACS (with or without ST elevation) have been randomized to either radial or femoral access for coronary angiography/intervention. The primary outcome is the composite of death, myocardial infarction, stroke, or non-coronary artery bypass graft-related major bleeding up to day 30. The key secondary outcomes are (1) death, myocardial infarction, or stroke up to day 30 and (2) non-coronary artery bypass graft-related major bleeding up to day 30. Percutaneous coronary intervention (PCI) success rates will also be compared between the two access sites. Conclusions The RIVAL trial will help define the optimal access site for coronary angiography/intervention in patients with ACS.002B12A03002B24A03002B12A05Cardiopathie coronaire01Coronary heart disease01Cardiopatía coronaria01Pathologie de l'appareil circulatoire02Cardiovascular disease02Aparato circulatorio patología02Conception09Design09Diseño09Etude comparative10Comparative study10Estudio comparativo10Fémur11Femur11Fémur11Accessibilité12Accessibility12Accesibilidad12Artère coronaire13Coronary artery13Arteria coronaria13Randomisation14Randomization14Aleatorización14Coronarographie15Coronary arteriography15Coronarografía15Homme16Human16Hombre16Malade17Patient17Enfermo17Appareil circulatoire18Circulatory system18Aparato circulatorio18Cardiologie19Cardiology19Cardiología19Syndrome coronaire aiguCD96Acute coronary syndromeCD96Síndrome coronario agudoCD96Radiodiagnostic37Radiodiagnosis37Radiodiagnóstico37Pathologie du myocarde38Myocardial disease38Miocardio patología38087OTOOTOPASCAL 11-0133626 INISTDesign and rationale of the Radial Vs. femorAL access for coronary intervention (RIVAL) trial: A randomized comparison of radial versus femoral access for coronary angiography or intervention in patients with acute coronary syndromesJOLLY (Sanjit S.); NIEMELÄ (Kari); XAVIER (Denis); WIDIMSKY (Petr); BUDAJ (Andrzej); VALENTIN (Vicent); LEWIS (Basil S.); AVEZUM (Alvaro); STEG (Philippe Gabriel); RAO (Sunil V.); CAIRNS (John); CHROLAVICIUS (Susan); YUSUF (Salim); MEHTA (Shamir R.)McMaster University and the Population Health Research Institute, Hamilton Health Sciences/Hamilton, Ontario/Canada (1 aut., 12 aut., 13 aut., 14 aut.); Tampere University Hospital/Tampere/Finlande (2 aut.); St John's Medical College and Research Institute/Bangalore/Inde (3 aut.); Charles University, Hospital Kralovske Vinohrady/Prague/Tchèque, République (4 aut.); Postgraduate Medical School, Department of Cardiology, Grochowski Hospital/Warsaw/Pologne (5 aut.); Hospital Universitari Dr Peset/Valencia/Espagne (6 aut.); Lady Davis Carmel Medical Center/Haifa/Israël (7 aut.); Dante Pazzanese Institute of Cardiology/Sao Paulo/Brésil (8 aut.); INSERM U-698. "Recherche Clinique en Athérothrombose." Université Paris 7 and Assistance Publique-Hôpitaux de Paris/Paris/France (9 aut.); Duke Clinical Research Institute, Duke University/Durham, North Carolina/Etats-Unis (10 aut.); University of British Columbia/Vancouver/Canada (11 aut.)
Publication en série; Niveau analytique
The American heart journal; ISSN 0002-8703; Coden AHJOA2; Etats-Unis; Da. 2011; Vol. 161; No. 2; Pp. 254-260; Bibl. 23 ref.AnglaisBackground Major bleeding in acute coronary syndromes (ACS) is associated with an increased risk of subsequent mortality and recurrent ischemic events. Observational data and small randomized trials suggest that radial instead of femoral access for coronary angiography/intervention results in fewer bleeding complications, with preserved and possibly improved efficacy. Radial access versus femoral access has yet to be formally evaluated in a randomized trial adequately powered for the comparison of clinically important outcomes. Objectives The aim of this study is to evaluate the efficacy and safety of radial versus femoral access for coronary angiography/intervention in patients with ACS managed with an invasive strategy. Design This was a multicenter international randomized trial with blinded assessment of outcomes. 7021 patients with ACS (with or without ST elevation) have been randomized to either radial or femoral access for coronary angiography/intervention. The primary outcome is the composite of death, myocardial infarction, stroke, or non-coronary artery bypass graft-related major bleeding up to day 30. The key secondary outcomes are (1) death, myocardial infarction, or stroke up to day 30 and (2) non-coronary artery bypass graft-related major bleeding up to day 30. Percutaneous coronary intervention (PCI) success rates will also be compared between the two access sites. Conclusions The RIVAL trial will help define the optimal access site for coronary angiography/intervention in patients with ACS.002B12A03; 002B24A03; 002B12A05Cardiopathie coronaire; Pathologie de l'appareil circulatoire; Conception; Etude comparative; Fémur; Accessibilité; Artère coronaire; Randomisation; Coronarographie; Homme; Malade; Appareil circulatoire; Cardiologie; Syndrome coronaire aiguRadiodiagnostic; Pathologie du myocardeCoronary heart disease; Cardiovascular disease; Design; Comparative study; Femur; Accessibility; Coronary artery; Randomization; Coronary arteriography; Human; Patient; Circulatory system; Cardiology; Acute coronary syndromeRadiodiagnosis; Myocardial diseaseCardiopatía coronaria; Aparato circulatorio patología; Diseño; Estudio comparativo; Fémur; Accesibilidad; Arteria coronaria; Aleatorización; Coronarografía; Hombre; Enfermo; Aparato circulatorio; Cardiología; Síndrome coronario agudoINIST-2057.35400019202069006011-0133626 001654 Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research GroupJ. AvouacRheumatology A Department, Paris Descartes University, Cochin HospitalParisFRA1 aut.11 aut.J. FransenDepartment of Rheumatology, Radboud University Nijmegen Medical CentreNijmegenNLD2 aut.U. A. WalkerDepartment of Rheumatology, Basel UniversityBaselCHE3 aut.17 aut.V. RiccieriSapienza University of Rome, Medical Clinic and Therapy DepartmentRomeITA4 aut.V. SmithDepartment of Rheumatology, Ghent University HospitalGhentBEL5 aut.C. MullerHospital de Clínicas da Universidade Federal do ParanaCuritibaBRA6 aut.9 aut.I. MiniatiDepartment of Medicine, Section of Rheumatology, University of FlorenceFlorenceITA7 aut.18 aut.I. H. TarnerDepartment of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-KlinikBad NauheimDEU8 aut.15 aut.S. Bellando RandoneHospital de Clínicas da Universidade Federal do ParanaCuritibaBRA6 aut.9 aut.M. CutoloDepartment of Internal Medicine, Research Laboratory and Academic Unit of Clinical Rheumatology, University of GenovaGenovaITA10 aut.Y. AllanoreRheumatology A Department, Paris Descartes University, Cochin HospitalParisFRA1 aut.11 aut.O. DistlerDepartment of Rheumatology, University Hospital ZurichZurichCHE12 aut.G. ValentiniRheumatology Section, Department of Clinical and Experimental Medicine, Second University of NaplesNaplesITA13 aut.L. CzirjakDepartment of Rheumatology,University of PécsPecsHUN14 aut.U. M Ller-LadnerDepartment of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-KlinikBad NauheimDEU8 aut.15 aut.D. E. FurstDivision of Rheumatology, Department of Medicine, David Geffen School at UCLALos Angeles, CaliforniaUSA16 aut.A. TyndallDepartment of Rheumatology, Basel UniversityBaselCHE3 aut.17 aut.M. Matucci-CerinicDepartment of Medicine, Section of Rheumatology, University of FlorenceFlorenceITA7 aut.18 aut.11-01352112011PASCAL 11-0135211 INISTPascal:11-01352110012440003-4967Ann. rheum. dis.Annals of the rheumatic diseasesDiagnosisRheumatologySclerodermaDiagnosticSclérodermieRhumatologie
Objective To identify a core set of preliminary items considered as important for the very early diagnosis of systemic sclerosis (SSc). Methods A list of items provided by European League Against Rheumatism (EULAR) Scleroderma Trial and Research(EUSTAR) centres were subjected to a Delphi exercise among 110 experts in the field of SSc. In round 1, experts were asked to choose the items they considered as the most important for the very early diagnosis of SSc. In round 2, experts were asked to reconsider the items accepted after the first stage. In round 3, the clinical relevance of selected items and their importance as measures that would lead to an early referral process were rated using appropriateness scores. Results Physicians from 85 EUSTAR centres participated in the study and provided an initial list of 121 items. After three Delphi rounds, the steering committee, with input from external experts, collapsed the 121 items into three domains containing seven items, developed as follows: skin domain (puffy fingers/puffy swollen digits turning into sclerodactily); vascular domain (Raynaud's phenomenon, abnormal capillaroscopy with scleroderma pattern) and laboratory domain (antinuclear, anticentromere and antitopoisomerase-I antibodies). Finally, the whole assembly of EUSTAR centres ratified with a majority vote the results in a final face-to-face meeting. Conclusion The three Delphi rounds allowed us to identify the items considered by experts as necessary for the very early diagnosis of SSc. The validation of these items to establish diagnostic criteria is currently ongoing in a prospective observational cohort.
0003-4967ARDIAOAnn. rheum. dis.703Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research GroupAVOUAC (J.)FRANSEN (J.)WALKER (U. A.)RICCIERI (V.)SMITH (V.)MULLER (C.)MINIATI (I.)TARNER (I. H.)BELLANDO RANDONE (S.)CUTOLO (M.)ALLANORE (Y.)DISTLER (O.)VALENTINI (G.)CZIRJAK (L.)MÜLLER-LADNER (U.)FURST (D. E.)TYNDALL (A.)MATUCCI-CERINIC (M.)Rheumatology A Department, Paris Descartes University, Cochin HospitalParisFRA1 aut.11 aut.Department of Rheumatology, Radboud University Nijmegen Medical CentreNijmegenNLD2 aut.Department of Rheumatology, Basel UniversityBaselCHE3 aut.17 aut.Sapienza University of Rome, Medical Clinic and Therapy DepartmentRomeITA4 aut.Department of Rheumatology, Ghent University HospitalGhentBEL5 aut.Hospital de Clínicas da Universidade Federal do ParanaCuritibaBRA6 aut.9 aut.Department of Medicine, Section of Rheumatology, University of FlorenceFlorenceITA7 aut.18 aut.Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-KlinikBad NauheimDEU8 aut.15 aut.Department of Internal Medicine, Research Laboratory and Academic Unit of Clinical Rheumatology, University of GenovaGenovaITA10 aut.Department of Rheumatology, University Hospital ZurichZurichCHE12 aut.Rheumatology Section, Department of Clinical and Experimental Medicine, Second University of NaplesNaplesITA13 aut.Department of Rheumatology,University of PécsPecsHUN14 aut.Division of Rheumatology, Department of Medicine, David Geffen School at UCLALos Angeles, CaliforniaUSA16 aut.EUSTAR GroupINC476-4812011ENGINIST63813540001936787001200000© 2011 INIST-CNRS. All rights reserved.16 ref.11-0135211PAAnnals of the rheumatic diseasesGBRObjective To identify a core set of preliminary items considered as important for the very early diagnosis of systemic sclerosis (SSc). Methods A list of items provided by European League Against Rheumatism (EULAR) Scleroderma Trial and Research(EUSTAR) centres were subjected to a Delphi exercise among 110 experts in the field of SSc. In round 1, experts were asked to choose the items they considered as the most important for the very early diagnosis of SSc. In round 2, experts were asked to reconsider the items accepted after the first stage. In round 3, the clinical relevance of selected items and their importance as measures that would lead to an early referral process were rated using appropriateness scores. Results Physicians from 85 EUSTAR centres participated in the study and provided an initial list of 121 items. After three Delphi rounds, the steering committee, with input from external experts, collapsed the 121 items into three domains containing seven items, developed as follows: skin domain (puffy fingers/puffy swollen digits turning into sclerodactily); vascular domain (Raynaud's phenomenon, abnormal capillaroscopy with scleroderma pattern) and laboratory domain (antinuclear, anticentromere and antitopoisomerase-I antibodies). Finally, the whole assembly of EUSTAR centres ratified with a majority vote the results in a final face-to-face meeting. Conclusion The three Delphi rounds allowed us to identify the items considered by experts as necessary for the very early diagnosis of SSc. The validation of these items to establish diagnostic criteria is currently ongoing in a prospective observational cohort.002B15002B07Diagnostic07Diagnosis07Diagnóstico07Sclérodermie08Scleroderma08Esclerodermia08Rhumatologie09Rheumatology09Reumatología09Maladie autoimmune37Autoimmune disease37Enfermedad autoinmune37Maladie de système38Systemic disease38Enfermedad sistémica38Pathologie de la peau39Skin disease39Piel patología39Pathologie du tissu conjonctif40Connective tissue disease40Tejido conjuntivo patología40Immunopathologie41Immunopathology41Inmunopatología41087OTOOTOPASCAL 11-0135211 INISTPreliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research GroupAVOUAC (J.); FRANSEN (J.); WALKER (U. A.); RICCIERI (V.); SMITH (V.); MULLER (C.); MINIATI (I.); TARNER (I. H.); BELLANDO RANDONE (S.); CUTOLO (M.); ALLANORE (Y.); DISTLER (O.); VALENTINI (G.); CZIRJAK (L.); MÜLLER-LADNER (U.); FURST (D. E.); TYNDALL (A.); MATUCCI-CERINIC (M.)Rheumatology A Department, Paris Descartes University, Cochin Hospital/Paris/France (1 aut., 11 aut.); Department of Rheumatology, Radboud University Nijmegen Medical Centre/Nijmegen/Pays-Bas (2 aut.); Department of Rheumatology, Basel University/Basel/Suisse (3 aut., 17 aut.); Sapienza University of Rome, Medical Clinic and Therapy Department/Rome/Italie (4 aut.); Department of Rheumatology, Ghent University Hospital/Ghent/Belgique (5 aut.); Hospital de Clínicas da Universidade Federal do Parana/Curitiba/Brésil (6 aut., 9 aut.); Department of Medicine, Section of Rheumatology, University of Florence/Florence/Italie (7 aut., 18 aut.); Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik/Bad Nauheim/Allemagne (8 aut., 15 aut.); Department of Internal Medicine, Research Laboratory and Academic Unit of Clinical Rheumatology, University of Genova/Genova/Italie (10 aut.); Department of Rheumatology, University Hospital Zurich/Zurich/Suisse (12 aut.); Rheumatology Section, Department of Clinical and Experimental Medicine, Second University of Naples/Naples/Italie (13 aut.); Department of Rheumatology,University of Pécs/Pecs/Hongrie (14 aut.); Division of Rheumatology, Department of Medicine, David Geffen School at UCLA/Los Angeles, California/Etats-Unis (16 aut.)
Publication en série; Niveau analytique
Annals of the rheumatic diseases; ISSN 0003-4967; Coden ARDIAO; Royaume-Uni; Da. 2011; Vol. 70; No. 3; Pp. 476-481; Bibl. 16 ref.AnglaisObjective To identify a core set of preliminary items considered as important for the very early diagnosis of systemic sclerosis (SSc). Methods A list of items provided by European League Against Rheumatism (EULAR) Scleroderma Trial and Research(EUSTAR) centres were subjected to a Delphi exercise among 110 experts in the field of SSc. In round 1, experts were asked to choose the items they considered as the most important for the very early diagnosis of SSc. In round 2, experts were asked to reconsider the items accepted after the first stage. In round 3, the clinical relevance of selected items and their importance as measures that would lead to an early referral process were rated using appropriateness scores. Results Physicians from 85 EUSTAR centres participated in the study and provided an initial list of 121 items. After three Delphi rounds, the steering committee, with input from external experts, collapsed the 121 items into three domains containing seven items, developed as follows: skin domain (puffy fingers/puffy swollen digits turning into sclerodactily); vascular domain (Raynaud's phenomenon, abnormal capillaroscopy with scleroderma pattern) and laboratory domain (antinuclear, anticentromere and antitopoisomerase-I antibodies). Finally, the whole assembly of EUSTAR centres ratified with a majority vote the results in a final face-to-face meeting. Conclusion The three Delphi rounds allowed us to identify the items considered by experts as necessary for the very early diagnosis of SSc. The validation of these items to establish diagnostic criteria is currently ongoing in a prospective observational cohort.002B15; 002B07Diagnostic; Sclérodermie; RhumatologieMaladie autoimmune; Maladie de système; Pathologie de la peau; Pathologie du tissu conjonctif; ImmunopathologieDiagnosis; Scleroderma; RheumatologyAutoimmune disease; Systemic disease; Skin disease; Connective tissue disease; ImmunopathologyDiagnóstico; Esclerodermia; ReumatologíaINIST-6381.35400019367870012011-0135211 001655 Morphological properties of superclusters of galaxiesM. V. Costa-DuarteInstituto de Astronomia, Geofísica e Ciências Atmosféricas, USP, R. do Matão 122605508-090 São PauloBRA1 aut.2 aut.L. Jr SodreInstituto de Astronomia, Geofísica e Ciências Atmosféricas, USP, R. do Matão 122605508-090 São PauloBRA1 aut.2 aut.F. DurretInstitut d'Astrophysique de Paris, UPMC Université Paris 06, UMR 709575014 ParisFRA3 aut.CNRS, UMR 7095, Institut d'Astrophysique de Paris75014 ParisFRA3 aut.11-01362172011PASCAL 11-0136217 INISTPascal:11-01362170012430035-8711Mon. Not. R. Astron. Soc.Monthly Notices of the Royal Astronomical SocietyAnticorrelationAstronomical cataloguesClassificationCosmologyData analysisFilamentary structureFilamentsFluctuationsGalaxiesGalaxy clustersGalaxy evolutionLarge-scale structureLuminosityMinkowski functionalModelsMonte Carlo methodsMorphologyPositionsSelection effectSky surveysSuperclustersVelocity spaceSuperamasGalaxiesEtude cielCatalogue astronomiqueModèleEvolution galaxiesEffet sélectionFonctionnelle MinkowskiFilamentAnticorrélationLuminositéStructure filamentaireMorphologiePositionEspace vitesseClassificationMéthode Monte CarloFluctuationCosmologieStructure grande échelleAmas galaxiesAnalyse donnée
We studied superclusters of galaxies in a volume-limited sample extracted from the Sloan Digital Sky Survey Data Release 7 and from mock catalogues based on a semi-analytical model of galaxy evolution in the Millennium Simulation. A density field method was applied to a sample of galaxies brighter than Mr = -21+5 log h100 to identify superclusters, taking into account selection and boundary effects. In order to evaluate the influence of the threshold density, we have chosen two thresholds: the first maximizes the number of objects (D1) and the second constrains the maximum supercluster size to ∼120 h-1 Mpc (D2). We have performed a morphological analysis, using Minkowski Functionals, based on a parameter, which increases monotonically from filaments to pancakes. An anticorrelation was found between supercluster richness (and total luminosity or size) and the morphological parameter, indicating that filamentary structures tend to be richer, larger and more luminous than pancakes in both observed and mock catalogues. We have also used the mock samples to compare supercluster morphologies identified in position and velocity spaces, concluding that our morphological classification is not biased by the peculiar velocities. Monte Carlo simulations designed to investigate the reliability of our results with respect to random fluctuations show that these results are robust. Our analysis indicates that filaments and pancakes present different luminosity and size distributions.
0035-8711MNRAA4Mon. Not. R. Astron. Soc.4113Morphological properties of superclusters of galaxiesCOSTA-DUARTE (M. V.)SODRE (L. JR)DURRET (F.)Instituto de Astronomia, Geofísica e Ciências Atmosféricas, USP, R. do Matão 122605508-090 São PauloBRA1 aut.2 aut.Institut d'Astrophysique de Paris, UPMC Université Paris 06, UMR 709575014 ParisFRA3 aut.CNRS, UMR 7095, Institut d'Astrophysique de Paris75014 ParisFRA3 aut.1716-17262011ENGINIST20673540001944086702500000© 2011 INIST-CNRS. All rights reserved.1/4 p.11-0136217PAMonthly Notices of the Royal Astronomical SocietyUSAWe studied superclusters of galaxies in a volume-limited sample extracted from the Sloan Digital Sky Survey Data Release 7 and from mock catalogues based on a semi-analytical model of galaxy evolution in the Millennium Simulation. A density field method was applied to a sample of galaxies brighter than Mr = -21+5 log h100 to identify superclusters, taking into account selection and boundary effects. In order to evaluate the influence of the threshold density, we have chosen two thresholds: the first maximizes the number of objects (D1) and the second constrains the maximum supercluster size to ∼120 h-1 Mpc (D2). We have performed a morphological analysis, using Minkowski Functionals, based on a parameter, which increases monotonically from filaments to pancakes. An anticorrelation was found between supercluster richness (and total luminosity or size) and the morphological parameter, indicating that filamentary structures tend to be richer, larger and more luminous than pancakes in both observed and mock catalogues. We have also used the mock samples to compare supercluster morphologies identified in position and velocity spaces, concluding that our morphological classification is not biased by the peculiar velocities. Monte Carlo simulations designed to investigate the reliability of our results with respect to random fluctuations show that these results are robust. Our analysis indicates that filaments and pancakes present different luminosity and size distributions.001E03Superamas26Superclusters26Galaxies27Galaxies27Etude ciel28Sky surveys28Catalogue astronomique29Astronomical catalogues29Modèle30Models30Modelo30Evolution galaxies31Galaxy evolution31Evolución galaxias31Effet sélection32Selection effect32Efecto selección32Fonctionnelle Minkowski33Minkowski functional33Funciónal Minkowski33Filament34Filaments34Anticorrélation35Anticorrelation35Anticorrelación35Luminosité36Luminosity36Structure filamentaire37Filamentary structure37Estructura filamentaria37Morphologie38Morphology38Position39Positions39Espace vitesse40Velocity space40Espacio velocidad40Classification41Classification41Méthode Monte Carlo42Monte Carlo methods42Fluctuation43Fluctuations43Cosmologie44Cosmology44Structure grande échelle45Large-scale structure45Amas galaxies46Galaxy clusters46Analyse donnée47Data analysis47087OTOOTOPASCAL 11-0136217 INISTMorphological properties of superclusters of galaxiesCOSTA-DUARTE (M. V.); SODRE (L. JR); DURRET (F.)Instituto de Astronomia, Geofísica e Ciências Atmosféricas, USP, R. do Matão 1226/05508-090 São Paulo/Brésil (1 aut., 2 aut.); Institut d'Astrophysique de Paris, UPMC Université Paris 06, UMR 7095/75014 Paris/France (3 aut.); CNRS, UMR 7095, Institut d'Astrophysique de Paris/75014 Paris/France (3 aut.)
Publication en série; Niveau analytique
Monthly Notices of the Royal Astronomical Society; ISSN 0035-8711; Coden MNRAA4; Etats-Unis; Da. 2011; Vol. 411; No. 3; Pp. 1716-1726; Bibl. 1/4 p.AnglaisWe studied superclusters of galaxies in a volume-limited sample extracted from the Sloan Digital Sky Survey Data Release 7 and from mock catalogues based on a semi-analytical model of galaxy evolution in the Millennium Simulation. A density field method was applied to a sample of galaxies brighter than Mr = -21+5 log h100 to identify superclusters, taking into account selection and boundary effects. In order to evaluate the influence of the threshold density, we have chosen two thresholds: the first maximizes the number of objects (D1) and the second constrains the maximum supercluster size to ∼120 h-1 Mpc (D2). We have performed a morphological analysis, using Minkowski Functionals, based on a parameter, which increases monotonically from filaments to pancakes. An anticorrelation was found between supercluster richness (and total luminosity or size) and the morphological parameter, indicating that filamentary structures tend to be richer, larger and more luminous than pancakes in both observed and mock catalogues. We have also used the mock samples to compare supercluster morphologies identified in position and velocity spaces, concluding that our morphological classification is not biased by the peculiar velocities. Monte Carlo simulations designed to investigate the reliability of our results with respect to random fluctuations show that these results are robust. Our analysis indicates that filaments and pancakes present different luminosity and size distributions.001E03Superamas; Galaxies; Etude ciel; Catalogue astronomique; Modèle; Evolution galaxies; Effet sélection; Fonctionnelle Minkowski; Filament; Anticorrélation; Luminosité; Structure filamentaire; Morphologie; Position; Espace vitesse; Classification; Méthode Monte Carlo; Fluctuation; Cosmologie; Structure grande échelle; Amas galaxies; Analyse donnéeSuperclusters; Galaxies; Sky surveys; Astronomical catalogues; Models; Galaxy evolution; Selection effect; Minkowski functional; Filaments; Anticorrelation; Luminosity; Filamentary structure; Morphology; Positions; Velocity space; Classification; Monte Carlo methods; Fluctuations; Cosmology; Large-scale structure; Galaxy clusters; Data analysisModelo; Evolución galaxias; Efecto selección; Funciónal Minkowski; Anticorrelación; Estructura filamentaria; Espacio velocidadINIST-2067.35400019440867025011-0136217 001656 On a Rational Transfer Function-Based Approach to H∞ Filtering Design for Time-Delay Linear SystemsRubens H. KoroguiDSCE/School of Electrical and Computer Engineering, UNICAMP13083-852, Campinas, SPBRA1 aut.3 aut.André R. FioravantiINRIA Saclay Ilê-de-France, Supélec91192, Gif-sur-YvetteFRA2 aut.José C. GeromelDSCE/School of Electrical and Computer Engineering, UNICAMP13083-852, Campinas, SPBRA1 aut.3 aut.11-01383942011PASCAL 11-0138394 INISTPascal:11-01383940012421053-587XIEEE trans. signal process.IEEE transactions on signal processingAlgorithmDelay systemDelay timeFilteringH infinite controlH infinite optimizationImplementationLinear systemRational functionRiccati equationSignal processingTheoretical studyTransfer functionFonction rationnelleFonction transfertCommande H infiniFiltrageTemps retardSystème à retardSystème linéaireOptimisation H infiniEquation RiccatiAlgorithmeImplémentationEtude théoriqueTraitement signal
This paper introduces a new procedure for H∞ filter design of time-delay linear systems. A finite-order LTI system, called comparison system, is defined in such a way that its H∞ norm is proven to be strongly related to the one of the time-delay system. Differently from what can be viewed as a common feature of filter design methods available in the literature to date, the one presented here treats the filtering design of time-delay systems with classical numerical routines based on Riccati equation and H∞ theory of LTI systems. The proposed algorithm is simple, efficient and easy to implement. Illustrative examples are solved and discussed in order to put in evidence the most relevant properties of the theoretical results. Furthermore, a practical application is presented.
1053-587XITPREDIEEE trans. signal process.593On a Rational Transfer Function-Based Approach to H∞ Filtering Design for Time-Delay Linear SystemsKOROGUI (Rubens H.)FIORAVANTI (André R.)GEROMEL (José C.)DSCE/School of Electrical and Computer Engineering, UNICAMP13083-852, Campinas, SPBRA1 aut.3 aut.INRIA Saclay Ilê-de-France, Supélec91192, Gif-sur-YvetteFRA2 aut.979-9882011ENGINIST222E33540001936988400900000© 2011 INIST-CNRS. All rights reserved.26 ref.11-0138394PAIEEE transactions on signal processingUSAThis paper introduces a new procedure for H∞ filter design of time-delay linear systems. A finite-order LTI system, called comparison system, is defined in such a way that its H∞ norm is proven to be strongly related to the one of the time-delay system. Differently from what can be viewed as a common feature of filter design methods available in the literature to date, the one presented here treats the filtering design of time-delay systems with classical numerical routines based on Riccati equation and H∞ theory of LTI systems. The proposed algorithm is simple, efficient and easy to implement. Illustrative examples are solved and discussed in order to put in evidence the most relevant properties of the theoretical results. Furthermore, a practical application is presented.001D04A04A2001D04A05DFonction rationnelle01Rational function01Función racional01Fonction transfert02Transfer function02Función traspaso02Commande H infini03H infinite control03Control H infinito03Filtrage04Filtering04Filtrado04Temps retard05Delay time05Tiempo retardo05Système à retard06Delay system06Sistema con retardo06Système linéaire07Linear system07Sistema lineal07Optimisation H infini08H infinite optimization08Optimización H infinito08Equation Riccati09Riccati equation09Ecuación Riccati09Algorithme10Algorithm10Algoritmo10Implémentation11Implementation11Implementación11Etude théorique12Theoretical study12Estudio teórico12Traitement signal46Signal processing46Procesamiento señal46094OTOOTOPASCAL 11-0138394 INISTOn a Rational Transfer Function-Based Approach to H∞ Filtering Design for Time-Delay Linear SystemsKOROGUI (Rubens H.); FIORAVANTI (André R.); GEROMEL (José C.)DSCE/School of Electrical and Computer Engineering, UNICAMP/13083-852, Campinas, SP/Brésil (1 aut., 3 aut.); INRIA Saclay Ilê-de-France, Supélec/91192, Gif-sur-Yvette/France (2 aut.)
Publication en série; Niveau analytique
IEEE transactions on signal processing; ISSN 1053-587X; Coden ITPRED; Etats-Unis; Da. 2011; Vol. 59; No. 3; Pp. 979-988; Bibl. 26 ref.AnglaisThis paper introduces a new procedure for H∞ filter design of time-delay linear systems. A finite-order LTI system, called comparison system, is defined in such a way that its H∞ norm is proven to be strongly related to the one of the time-delay system. Differently from what can be viewed as a common feature of filter design methods available in the literature to date, the one presented here treats the filtering design of time-delay systems with classical numerical routines based on Riccati equation and H∞ theory of LTI systems. The proposed algorithm is simple, efficient and easy to implement. Illustrative examples are solved and discussed in order to put in evidence the most relevant properties of the theoretical results. Furthermore, a practical application is presented.001D04A04A2; 001D04A05DFonction rationnelle; Fonction transfert; Commande H infini; Filtrage; Temps retard; Système à retard; Système linéaire; Optimisation H infini; Equation Riccati; Algorithme; Implémentation; Etude théorique; Traitement signalRational function; Transfer function; H infinite control; Filtering; Delay time; Delay system; Linear system; H infinite optimization; Riccati equation; Algorithm; Implementation; Theoretical study; Signal processingFunción racional; Función traspaso; Control H infinito; Filtrado; Tiempo retardo; Sistema con retardo; Sistema lineal; Optimización H infinito; Ecuación Riccati; Algoritmo; Implementación; Estudio teórico; Procesamiento señalINIST-222E3.35400019369884009011-0138394 001657 Geochemistry and spatial distribution of heavy metals in Oxisols in a mineralized region of the Brazilian Central PlateauDiego Lang BurakUniversidade Federal do Espírito Santo, Departamento de Produção Vegetal29500-000 Alegre-ESBRA1 aut.Mauricio P. F. FontesUniversidade Federal de Viçosa, Departamento de Solos36570-000, Viçoso-MGBRA2 aut.Nerilson Terra SantosUniversidade Federal de Viçosa, Departamento de Estatistica36570-000, Viçosa-MGBRA3 aut.Lena Virginia Soares MonteiroUniversidade Estadual de Campinas, Instituto de Geociências13083-970, Campinas-SPBRA4 aut.Eder De Sousa MartinsEmbrapa Cerrados, Caixa Postal 0822373010-970 Planaltina-DFBRA5 aut.Thierry BecquerIRD, UMR 210 Eco&Sols, INRA/SupAgro, 2 Place Viala34060 MontpellierFRA6 aut.11-01390932010PASCAL 11-0139093 INISTPascal:11-01390930012410016-7061Geoderma : (Amst.)Geoderma : (Amsterdam)BrazilContentEnvironmental effectMinas Gerais BrazilOxisolsSpatial distributionTropical soilcorrelation coefficientdigital elevation modelserosionheavy metalslandscapesmetalsmobilityphysical weatheringprincipal components analysisspatial distributiontrace-element analysesAnalyse éléments tracesDistribution spatialeRépartition spatialeMétal lourdOxisolModèle numérique élévationSol tropicalCoefficient corrélationErosionAnalyse composante principalePaysageElément métalliqueMobilitéTeneurAltération physiqueEffet environnementBrésilMinas Gerais
The majority of the soils of the Central Plateau of Brazil are product of long time development over stable surfaces, usually associated with erosion and re-deposition cycles. In this context, to successfully study the geochemistry and spatial distribution of heavy metals, it is essential to understand the geology as well as the geomorphology of the landscape and the properties of the metals related to their mobility. The main objective of this work was to evaluate contents of naturally occurring heavy metals (Co, Cu, Mn, Ni, Pb and Zn) in some highly weathered tropical soils as related to their geochemistry, geology and geomorphology. Additionally, it was aimed to interpret the spatial distribution patterns of these metals and of major elements (Al, Fe, Ti and Mg), evaluating the association and taking the influence of the geology and geomorphology into consideration. In geo-referenced sites, ranging from 480 to 1040 m in altitude, samples were collected at two depths (0-20 and 60-80 cm), ground, sieved, and prepared for analysis. Heavy metals and major element contents were determined by extraction with aqua regia. Descriptive statistics, Pearson correlation coefficients, Principal Components Analysis (PCA) and spatial variability analyses were conducted and soil metal concentrations for the whole area were predicted by kriging (interpolation). A close association between Pb, Zn, and Mn was observed using PCA and Pearson's correlation. Highest concentrations of Pb, Zn, and Mn were determined in soils between 650 and 550 m altitude surrounding the dolomite massif hills and Ambrósia and Fagundes mineral deposits. Copper and Fe were found to be geochemically associated with highest concentrations observed in soils formed from carbonaceous phyllite with quartzite layers. Cobalt and Ni concentrations were associated with areas characterized geomorphologically as alluvial-colluvial deposits at the lowest altitudes within the region. Although there is a marked dispersive action of tropical weathering on metal distribution in the region, Cu, Pb, and Zn were found spatially associated with their geological source. This probably happens because of greater affinity of those metals to Fe and Mn oxides formed predominantly under tropical conditions and present in higher concentrations near to the sources of these heavy metals. On the other hand, both the low affinity of Ni and Co for these oxide minerals and the region's geomorphology allowed for their migration towards the drainage network to the regions of sediment accumulation at lower altitudes during the landscape's evolution.
0016-7061GEDMABGeoderma : (Amst.)1602Geochemistry and spatial distribution of heavy metals in Oxisols in a mineralized region of the Brazilian Central PlateauLANG BURAK (Diego)FONTES (Mauricio P. F.)TERRA SANTOS (Nerilson)SOARES MONTEIRO (Lena Virginia)DE SOUSA MARTINS (Eder)BECQUER (Thierry)Universidade Federal do Espírito Santo, Departamento de Produção Vegetal29500-000 Alegre-ESBRA1 aut.Universidade Federal de Viçosa, Departamento de Solos36570-000, Viçoso-MGBRA2 aut.Universidade Federal de Viçosa, Departamento de Estatistica36570-000, Viçosa-MGBRA3 aut.Universidade Estadual de Campinas, Instituto de Geociências13083-970, Campinas-SPBRA4 aut.Embrapa Cerrados, Caixa Postal 0822373010-970 Planaltina-DFBRA5 aut.IRD, UMR 210 Eco&Sols, INRA/SupAgro, 2 Place Viala34060 MontpellierFRA6 aut.131-1422010ENGINIST36073540001943400100100000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0139093PAGeoderma : (Amsterdam)NLDThe majority of the soils of the Central Plateau of Brazil are product of long time development over stable surfaces, usually associated with erosion and re-deposition cycles. In this context, to successfully study the geochemistry and spatial distribution of heavy metals, it is essential to understand the geology as well as the geomorphology of the landscape and the properties of the metals related to their mobility. The main objective of this work was to evaluate contents of naturally occurring heavy metals (Co, Cu, Mn, Ni, Pb and Zn) in some highly weathered tropical soils as related to their geochemistry, geology and geomorphology. Additionally, it was aimed to interpret the spatial distribution patterns of these metals and of major elements (Al, Fe, Ti and Mg), evaluating the association and taking the influence of the geology and geomorphology into consideration. In geo-referenced sites, ranging from 480 to 1040 m in altitude, samples were collected at two depths (0-20 and 60-80 cm), ground, sieved, and prepared for analysis. Heavy metals and major element contents were determined by extraction with aqua regia. Descriptive statistics, Pearson correlation coefficients, Principal Components Analysis (PCA) and spatial variability analyses were conducted and soil metal concentrations for the whole area were predicted by kriging (interpolation). A close association between Pb, Zn, and Mn was observed using PCA and Pearson's correlation. Highest concentrations of Pb, Zn, and Mn were determined in soils between 650 and 550 m altitude surrounding the dolomite massif hills and Ambrósia and Fagundes mineral deposits. Copper and Fe were found to be geochemically associated with highest concentrations observed in soils formed from carbonaceous phyllite with quartzite layers. Cobalt and Ni concentrations were associated with areas characterized geomorphologically as alluvial-colluvial deposits at the lowest altitudes within the region. Although there is a marked dispersive action of tropical weathering on metal distribution in the region, Cu, Pb, and Zn were found spatially associated with their geological source. This probably happens because of greater affinity of those metals to Fe and Mn oxides formed predominantly under tropical conditions and present in higher concentrations near to the sources of these heavy metals. On the other hand, both the low affinity of Ni and Co for these oxide minerals and the region's geomorphology allowed for their migration towards the drainage network to the regions of sediment accumulation at lower altitudes during the landscape's evolution.002A32001E01P03001E01B03226C03220B03Analyse éléments traces01trace-element analyses01Análisis elementos traza01Distribution spatiale02spatial distribution02Distribución espacial02Répartition spatiale03Spatial distribution03Distribución espacial03Métal lourd04heavy metals04Metal pesado04OxisolNT05OxisolsNT05OxisolsNT05Modèle numérique élévation06digital elevation models06Sol tropicalNT07Tropical soilNT07Suelo tropicalNT07Coefficient corrélation08correlation coefficient08Coeficiente correlación08Erosion09erosion09Erosión09Analyse composante principale10principal components analysis10Análisis componente principal10Paysage14landscapes14Paisaje14Elément métallique16metals16Elemento metálico16Mobilité17mobility17Movilidad17Teneur18Content18Proporción18Altération physique20physical weathering20Alteración física20Effet environnement21Environmental effect21Efecto medio ambiente21BrésilNG61BrazilNG61BrasilNG61Minas GeraisNG62Minas Gerais BrazilNG62Minas GeraisNG62SolNTsoilsNTSueloNTAmérique du Sud564South America564America del sur564094PASCAL 11-0139093 INISTGeochemistry and spatial distribution of heavy metals in Oxisols in a mineralized region of the Brazilian Central PlateauLANG BURAK (Diego); FONTES (Mauricio P. F.); TERRA SANTOS (Nerilson); SOARES MONTEIRO (Lena Virginia); DE SOUSA MARTINS (Eder); BECQUER (Thierry)Universidade Federal do Espírito Santo, Departamento de Produção Vegetal/29500-000 Alegre-ES/Brésil (1 aut.); Universidade Federal de Viçosa, Departamento de Solos/36570-000, Viçoso-MG/Brésil (2 aut.); Universidade Federal de Viçosa, Departamento de Estatistica/36570-000, Viçosa-MG/Brésil (3 aut.); Universidade Estadual de Campinas, Instituto de Geociências/13083-970, Campinas-SP/Brésil (4 aut.); Embrapa Cerrados, Caixa Postal 08223/73010-970 Planaltina-DF/Brésil (5 aut.); IRD, UMR 210 Eco&Sols, INRA/SupAgro, 2 Place Viala/34060 Montpellier/France (6 aut.)
Publication en série; Niveau analytique
Geoderma : (Amsterdam); ISSN 0016-7061; Coden GEDMAB; Pays-Bas; Da. 2010; Vol. 160; No. 2; Pp. 131-142; Bibl. 3/4 p.AnglaisThe majority of the soils of the Central Plateau of Brazil are product of long time development over stable surfaces, usually associated with erosion and re-deposition cycles. In this context, to successfully study the geochemistry and spatial distribution of heavy metals, it is essential to understand the geology as well as the geomorphology of the landscape and the properties of the metals related to their mobility. The main objective of this work was to evaluate contents of naturally occurring heavy metals (Co, Cu, Mn, Ni, Pb and Zn) in some highly weathered tropical soils as related to their geochemistry, geology and geomorphology. Additionally, it was aimed to interpret the spatial distribution patterns of these metals and of major elements (Al, Fe, Ti and Mg), evaluating the association and taking the influence of the geology and geomorphology into consideration. In geo-referenced sites, ranging from 480 to 1040 m in altitude, samples were collected at two depths (0-20 and 60-80 cm), ground, sieved, and prepared for analysis. Heavy metals and major element contents were determined by extraction with aqua regia. Descriptive statistics, Pearson correlation coefficients, Principal Components Analysis (PCA) and spatial variability analyses were conducted and soil metal concentrations for the whole area were predicted by kriging (interpolation). A close association between Pb, Zn, and Mn was observed using PCA and Pearson's correlation. Highest concentrations of Pb, Zn, and Mn were determined in soils between 650 and 550 m altitude surrounding the dolomite massif hills and Ambrósia and Fagundes mineral deposits. Copper and Fe were found to be geochemically associated with highest concentrations observed in soils formed from carbonaceous phyllite with quartzite layers. Cobalt and Ni concentrations were associated with areas characterized geomorphologically as alluvial-colluvial deposits at the lowest altitudes within the region. Although there is a marked dispersive action of tropical weathering on metal distribution in the region, Cu, Pb, and Zn were found spatially associated with their geological source. This probably happens because of greater affinity of those metals to Fe and Mn oxides formed predominantly under tropical conditions and present in higher concentrations near to the sources of these heavy metals. On the other hand, both the low affinity of Ni and Co for these oxide minerals and the region's geomorphology allowed for their migration towards the drainage network to the regions of sediment accumulation at lower altitudes during the landscape's evolution.002A32; 001E01P03; 001E01B03; 226C03; 220B03Analyse éléments traces; Distribution spatiale; Répartition spatiale; Métal lourd; Oxisol; Modèle numérique élévation; Sol tropical; Coefficient corrélation; Erosion; Analyse composante principale; Paysage; Elément métallique; Mobilité; Teneur; Altération physique; Effet environnement; Brésil; Minas GeraisSol; Amérique du Sudtrace-element analyses; spatial distribution; Spatial distribution; heavy metals; Oxisols; digital elevation models; Tropical soil; correlation coefficient; erosion; principal components analysis; landscapes; metals; mobility; Content; physical weathering; Environmental effect; Brazil; Minas Gerais Brazilsoils; South AmericaAnálisis elementos traza; Distribución espacial; Distribución espacial; Metal pesado; Oxisols; Suelo tropical; Coeficiente correlación; Erosión; Análisis componente principal; Paisaje; Elemento metálico; Movilidad; Proporción; Alteración física; Efecto medio ambiente; Brasil; Minas GeraisINIST-3607.35400019434001001011-0139093 001658 Simulating N<sub>2</sub>0 fluxes from a Brazilian cropped soil with contrasted tillage practicesA. MetayMontpellier Supagro, UMR SYSTEM (INRA-CIRAD-SupAgro), Bât. 27, 2 place Viala34060 MontpellierFRA1 aut.L. Chapuis-LardyIRD, UMR 210 Eco&Sols, Bel Air, BP 1386CP 18524 DakarSEN2 aut.A. FindelingCREED-Veolia, 291 Avenue Dreyfous Ducas78520 LimayFRA3 aut.R. OliverCIRAD, UPR 78, avenue Agropolis34394 MontpellierFRA4 aut.J. A. Alves MoreiraEMBRAPA-CNPAF Rodovia Goidnia a Nova Veneza, km 12, Fazenda Capivara, C.P. 17975375-000 Santo Antônio de Goiás, GOBRA5 aut.C. FellerIRD, UMR 210 Eco&Sols, Batiment 12, 2 place Viala34060 MontpellierFRA6 aut.11-01394902011PASCAL 11-0139490 INISTPascal:11-01394900012400167-8809Agric. ecosyst. environ.Agriculture, ecosystems & environmentBrazilCropping systemCultivated soilEcologyFluxNitrogen protoxideSimulationSoil tillageTropical soilSimulationFluxTravail solSystème cultureEcologieProtoxyde d'azoteBrésilSol cultivéSol tropical
Assessing the N20 fluxes balance is a key challenge to estimate the effect of agriculture practices on greenhouse gas production. N2O fluxes remained difficult to measure on a field scale due to high spatial and temporal variability and usually low concentrations. Our work aimed at (i) characterizing by laboratory measurements soil potential N2O emissions from nitrification and denitrification and (ii) testing a modelling approach of N2O emissions that circumvents the problem of discrete measurements for two Brazilian rainfed rice cropping systems, no-tillage (NT) vs. disk tillage (DT). This latter approach consisted in the combination of 2 models: a mechanistic water transfer model and a N2O emission model, namely PASTIS and NOE. Simulations with the PASTIS + NOE approach showed for both NT and DTtreatments that: (i) the soil emitted low amounts of N2O, (ii) emissions by denitrification corresponded to short periods of high N2O emissions (15 times as high as emission by nitrification), (iii) nitrification contributed to ca 35% of the total N2O emissions at the crop cycle scale, (iv) field N20 emission measurements corresponded to the low bound of simulated emissions from nitrification.
0167-8809AEENDOAgric. ecosyst. environ.1401-2Simulating N20 fluxes from a Brazilian cropped soil with contrasted tillage practicesMETAY (A.)CHAPUIS-LARDY (L.)FINDELING (A.)OLIVER (R.)MOREIRA (J. A. Alves)FELLER (C.)Montpellier Supagro, UMR SYSTEM (INRA-CIRAD-SupAgro), Bât. 27, 2 place Viala34060 MontpellierFRA1 aut.IRD, UMR 210 Eco&Sols, Bel Air, BP 1386CP 18524 DakarSEN2 aut.CREED-Veolia, 291 Avenue Dreyfous Ducas78520 LimayFRA3 aut.CIRAD, UPR 78, avenue Agropolis34394 MontpellierFRA4 aut.EMBRAPA-CNPAF Rodovia Goidnia a Nova Veneza, km 12, Fazenda Capivara, C.P. 17975375-000 Santo Antônio de Goiás, GOBRA5 aut.IRD, UMR 210 Eco&Sols, Batiment 12, 2 place Viala34060 MontpellierFRA6 aut.255-2632011ENGINIST165353540001944160002900000© 2011 INIST-CNRS. All rights reserved.1 p.1/411-0139490PAAgriculture, ecosystems & environmentGBRAssessing the N20 fluxes balance is a key challenge to estimate the effect of agriculture practices on greenhouse gas production. N2O fluxes remained difficult to measure on a field scale due to high spatial and temporal variability and usually low concentrations. Our work aimed at (i) characterizing by laboratory measurements soil potential N2O emissions from nitrification and denitrification and (ii) testing a modelling approach of N2O emissions that circumvents the problem of discrete measurements for two Brazilian rainfed rice cropping systems, no-tillage (NT) vs. disk tillage (DT). This latter approach consisted in the combination of 2 models: a mechanistic water transfer model and a N2O emission model, namely PASTIS and NOE. Simulations with the PASTIS + NOE approach showed for both NT and DTtreatments that: (i) the soil emitted low amounts of N2O, (ii) emissions by denitrification corresponded to short periods of high N2O emissions (15 times as high as emission by nitrification), (iii) nitrification contributed to ca 35% of the total N2O emissions at the crop cycle scale, (iv) field N20 emission measurements corresponded to the low bound of simulated emissions from nitrification.002A32C04B2002A32C01B1002A32C04A002A32BSimulation01Simulation01Simulación01Flux02Flux02Flujo02Travail sol03Soil tillage03Labranza03Système culture04Cropping system04Sistema cultural04Ecologie05Ecology05Ecología05Protoxyde d'azoteNKFX15Nitrogen protoxideNKFX15Nitrógeno protóxidoNKFX15BrésilNG20BrazilNG20BrasilNG20Sol cultivéNT24Cultivated soilNT24Suelo cultivadoNT24Sol tropicalNT25Tropical soilNT25Suelo tropicalNT25Amérique du SudNGSouth AmericaNGAmerica del surNGAmériqueNGAmericaNGAmericaNG094OTOOTOPASCAL 11-0139490 INISTSimulating N20 fluxes from a Brazilian cropped soil with contrasted tillage practicesMETAY (A.); CHAPUIS-LARDY (L.); FINDELING (A.); OLIVER (R.); MOREIRA (J. A. Alves); FELLER (C.)Montpellier Supagro, UMR SYSTEM (INRA-CIRAD-SupAgro), Bât. 27, 2 place Viala/34060 Montpellier/France (1 aut.); IRD, UMR 210 Eco&Sols, Bel Air, BP 1386/CP 18524 Dakar/Sénégal (2 aut.); CREED-Veolia, 291 Avenue Dreyfous Ducas/78520 Limay/France (3 aut.); CIRAD, UPR 78, avenue Agropolis/34394 Montpellier/France (4 aut.); EMBRAPA-CNPAF Rodovia Goidnia a Nova Veneza, km 12, Fazenda Capivara, C.P. 179/75375-000 Santo Antônio de Goiás, GO/Brésil (5 aut.); IRD, UMR 210 Eco&Sols, Batiment 12, 2 place Viala/34060 Montpellier/France (6 aut.)
Publication en série; Niveau analytique
Agriculture, ecosystems & environment; ISSN 0167-8809; Coden AEENDO; Royaume-Uni; Da. 2011; Vol. 140; No. 1-2; Pp. 255-263; Bibl. 1 p.1/4AnglaisAssessing the N20 fluxes balance is a key challenge to estimate the effect of agriculture practices on greenhouse gas production. N2O fluxes remained difficult to measure on a field scale due to high spatial and temporal variability and usually low concentrations. Our work aimed at (i) characterizing by laboratory measurements soil potential N2O emissions from nitrification and denitrification and (ii) testing a modelling approach of N2O emissions that circumvents the problem of discrete measurements for two Brazilian rainfed rice cropping systems, no-tillage (NT) vs. disk tillage (DT). This latter approach consisted in the combination of 2 models: a mechanistic water transfer model and a N2O emission model, namely PASTIS and NOE. Simulations with the PASTIS + NOE approach showed for both NT and DTtreatments that: (i) the soil emitted low amounts of N2O, (ii) emissions by denitrification corresponded to short periods of high N2O emissions (15 times as high as emission by nitrification), (iii) nitrification contributed to ca 35% of the total N2O emissions at the crop cycle scale, (iv) field N20 emission measurements corresponded to the low bound of simulated emissions from nitrification.002A32C04B2; 002A32C01B1; 002A32C04A; 002A32BSimulation; Flux; Travail sol; Système culture; Ecologie; Protoxyde d'azote; Brésil; Sol cultivé; Sol tropicalAmérique du Sud; AmériqueSimulation; Flux; Soil tillage; Cropping system; Ecology; Nitrogen protoxide; Brazil; Cultivated soil; Tropical soilSouth America; AmericaSimulación; Flujo; Labranza; Sistema cultural; Ecología; Nitrógeno protóxido; Brasil; Suelo cultivado; Suelo tropicalINIST-16535.35400019441600029011-0139490 001659 Search for Antifungal Compounds from the Wood of Durable Tropical TreesAlice M. S. RodriguesCNRS, UMR ECOFOG, Université des Antilles et de la Guyane97300 CayenneFRA1 aut.3 aut.4 aut.7 aut.8 aut.Labaratório de Farmacognosia, Universidade de BrasíliaBrasíliaBRA1 aut.4 aut.7 aut.Phellipe N. E. T. TheodoroInstituto de Patologia Tropical e Saúde Pública, Universidade Federal de GoiásGoiâniaBRA2 aut.5 aut.Véronique EparvierCNRS, UMR ECOFOG, Université des Antilles et de la Guyane97300 CayenneFRA1 aut.3 aut.4 aut.7 aut.8 aut.Charlie BassetCNRS, UMR ECOFOG, Université des Antilles et de la Guyane97300 CayenneFRA1 aut.3 aut.4 aut.7 aut.8 aut.Labaratório de Farmacognosia, Universidade de BrasíliaBrasíliaBRA1 aut.4 aut.7 aut.Maria R. R. SilvaInstituto de Patologia Tropical e Saúde Pública, Universidade Federal de GoiásGoiâniaBRA2 aut.5 aut.Jacques BeaucheneCIRAD, UMR ECOFOG, BP 70997387 KourouFRA6 aut.Laila S. EspindolaCNRS, UMR ECOFOG, Université des Antilles et de la Guyane97300 CayenneFRA1 aut.3 aut.4 aut.7 aut.8 aut.Labaratório de Farmacognosia, Universidade de BrasíliaBrasíliaBRA1 aut.4 aut.7 aut.Didier StienCNRS, UMR ECOFOG, Université des Antilles et de la Guyane97300 CayenneFRA1 aut.3 aut.4 aut.7 aut.8 aut.11-01404522010PASCAL 11-0140452 INISTPascal:11-01404520012390163-3864J. nat. prod. : (Print)Journal of natural products : (Print)Acetylenic compoundAliphatic compoundAntifungal agentBiological activityEthylenic compoundFive membered ringFrench GuianaGlycolIn vitroIsolationLactoneLauraceaeMedicinal plantOxygen heterocyclePharmacognosyPlant originTropical woodAntifongiqueIsolementBois tropicalPlante médicinaleHétérocycle oxygèneCycle 5 chaînonsLactoneGlycolComposé aliphatiqueComposé éthyléniqueComposé acétyléniqueActivité biologiqueGuyane FrançaiseIn vitroLauraceaePharmacognosieOrigine végétaleSextonia rubraRubrénolideRubrynolideFuran-2-one(5-déc-9-ényl-4,5-dihydro-3-[2,3-dihydroxypropyl])Furan-2-one(5-déc-9-ynyl-4,5-dihydro-3-[2,3-dihydroxypropyl])
Research on antifungal compounds from the durable wood from French Guiana Amazonian forest trees highlights the correlation between the activity of their extracts against wood-rotting fungi and human pathogens. The fractionation of an ethyl acetate extract of Sextonia rubra wood led to the isolation of rubrenolide (1) and rubrynolide (2). The potential of compounds 1 and 2 is described through the evaluation of their activity against 16 pathogenic fungi and their cytotoxicity toward NIH-3T3 mammalian fibroblast cells.
0163-3864JNPRDFJ. nat. prod. : (Print)7310Search for Antifungal Compounds from the Wood of Durable Tropical TreesRODRIGUES (Alice M. S.)THEODORO (Phellipe N. E. T.)EPARVIER (Véronique)BASSET (Charlie)SILVA (Maria R. R.)BEAUCHENE (Jacques)ESPINDOLA (Laila S.)STIEN (Didier)CNRS, UMR ECOFOG, Université des Antilles et de la Guyane97300 CayenneFRA1 aut.3 aut.4 aut.7 aut.8 aut.Labaratório de Farmacognosia, Universidade de BrasíliaBrasíliaBRA1 aut.4 aut.7 aut.Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de GoiásGoiâniaBRA2 aut.5 aut.CIRAD, UMR ECOFOG, BP 70997387 KourouFRA6 aut.1706-17072010ENGINIST41273540001933085201500000© 2011 INIST-CNRS. All rights reserved.13 ref.11-0140452PAJournal of natural products : (Print)USAResearch on antifungal compounds from the durable wood from French Guiana Amazonian forest trees highlights the correlation between the activity of their extracts against wood-rotting fungi and human pathogens. The fractionation of an ethyl acetate extract of Sextonia rubra wood led to the isolation of rubrenolide (1) and rubrynolide (2). The potential of compounds 1 and 2 is described through the evaluation of their activity against 16 pathogenic fungi and their cytotoxicity toward NIH-3T3 mammalian fibroblast cells.002B02A04Antifongique01Antifungal agent01Antifúngico01Isolement02Isolation02Aislamiento02Bois tropical03Tropical wood03Madera tropical03Plante médicinale04Medicinal plant04Planta medicinal04Hétérocycle oxygène05Oxygen heterocycle05Heterociclo oxígeno05Cycle 5 chaînons06Five membered ring06Ciclo 5 eslabones06Lactone07Lactone07Lactona07Glycol08Glycol08Glicol08Composé aliphatique09Aliphatic compound09Compuesto alifático09Composé éthylénique10Ethylenic compound10Compuesto etilénico10Composé acétylénique11Acetylenic compound11Compuesto acetilénico11Activité biologique12Biological activity12Actividad biológica12Guyane FrançaiseNG13French GuianaNG13Guayana francesaNG13In vitro14In vitro14In vitro14LauraceaeNS32LauraceaeNS32LauraceaeNS32Pharmacognosie33Pharmacognosy33Farmacognosia33Origine végétale34Plant origin34Origen vegetal34Sextonia rubraNSINC76RubrénolideNKINC77RubrynolideNKINC78Furan-2-one(5-déc-9-ényl-4,5-dihydro-3-[2,3-dihydroxypropyl])NKINC79Furan-2-one(5-déc-9-ynyl-4,5-dihydro-3-[2,3-dihydroxypropyl])NKINC80Amérique du SudNGSouth AmericaNGAmerica del surNGAmériqueNGAmericaNGAmericaNGDicotyledonesNSDicotyledonesNSDicotyledonesNSAngiospermaeNSAngiospermaeNSAngiospermaeNSSpermatophytaNSSpermatophytaNSSpermatophytaNS094PASCAL 11-0140452 INISTSearch for Antifungal Compounds from the Wood of Durable Tropical TreesRODRIGUES (Alice M. S.); THEODORO (Phellipe N. E. T.); EPARVIER (Véronique); BASSET (Charlie); SILVA (Maria R. R.); BEAUCHENE (Jacques); ESPINDOLA (Laila S.); STIEN (Didier)CNRS, UMR ECOFOG, Université des Antilles et de la Guyane/97300 Cayenne/France (1 aut., 3 aut., 4 aut., 7 aut., 8 aut.); Labaratório de Farmacognosia, Universidade de Brasília/Brasília/Brésil (1 aut., 4 aut., 7 aut.); Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás/Goiânia/Brésil (2 aut., 5 aut.); CIRAD, UMR ECOFOG, BP 709/97387 Kourou/France (6 aut.)
Publication en série; Niveau analytique
Journal of natural products : (Print); ISSN 0163-3864; Coden JNPRDF; Etats-Unis; Da. 2010; Vol. 73; No. 10; Pp. 1706-1707; Bibl. 13 ref.AnglaisResearch on antifungal compounds from the durable wood from French Guiana Amazonian forest trees highlights the correlation between the activity of their extracts against wood-rotting fungi and human pathogens. The fractionation of an ethyl acetate extract of Sextonia rubra wood led to the isolation of rubrenolide (1) and rubrynolide (2). The potential of compounds 1 and 2 is described through the evaluation of their activity against 16 pathogenic fungi and their cytotoxicity toward NIH-3T3 mammalian fibroblast cells.002B02A04Antifongique; Isolement; Bois tropical; Plante médicinale; Hétérocycle oxygène; Cycle 5 chaînons; Lactone; Glycol; Composé aliphatique; Composé éthylénique; Composé acétylénique; Activité biologique; Guyane Française; In vitro; Lauraceae; Pharmacognosie; Origine végétale; Sextonia rubra; Rubrénolide; Rubrynolide; Furan-2-one(5-déc-9-ényl-4,5-dihydro-3-[2,3-dihydrox ypropyl]); Furan-2-one(5-déc-9-ynyl-4,5-dihydro-3-[2,3 -dihydroxypropyl])Amérique du Sud; Amérique; Dicotyledones; Angiospermae; SpermatophytaAntifungal agent; Isolation; Tropical wood; Medicinal plant; Oxygen heterocycle; Five membered ring; Lactone; Glycol; Aliphatic compound; Ethylenic compound; Acetylenic compound; Biological activity; French Guiana; In vitro; Lauraceae; Pharmacognosy; Plant originSouth America; America; Dicotyledones; Angiospermae; SpermatophytaAntifúngico; Aislamiento; Madera tropical; Planta medicinal; Heterociclo oxígeno; Ciclo 5 eslabones; Lactona; Glicol; Compuesto alifático; Compuesto etilénico; Compuesto acetilénico; Actividad biológica; Guayana francesa; In vitro; Lauraceae; Farmacognosia; Origen vegetalINIST-4127.35400019330852015011-0140452 001660 Telavancin versus Vancomycin for Hospital-Acquired Pneumonia due to Gram-positive PathogensEthan RubinsteinSection of Infectiols Diseases Department of Internal Medicine and Medical Microbiology, University of ManitobaWinnipeg, ManitobaCAN1 aut.Tahaniyat LalaniDepartment of Medicine, Duke Clinical Research InstituteUSA2 aut.3 aut.20 aut.Department of Medicine, Division of Infectious Diseases, Duke University Medical CenterDurham, North CarolinaUSA2 aut.3 aut.G. Ralph CoreyDepartment of Medicine, Duke Clinical Research InstituteUSA2 aut.3 aut.20 aut.Department of Medicine, Division of Infectious Diseases, Duke University Medical CenterDurham, North CarolinaUSA2 aut.3 aut.Zeina A. KanafaniAmerican University of Beirut Medical CenterBeirutLBN4 aut.Esteban C. NanniniDepartment of Infectious Diseases, School of Medicine, Universidad Nacional de RosarioRosarioUSA5 aut.Marcelo G. RochaIntensive Care Unit, Paviihão Pereira Filho, Irmandade da Santa CasaPorto AlegreBRA6 aut.Galia RahavDivision of Infectious Diseases Department of Medicine, Sheba Medical CenterTel HashomerISR7 aut.Michael S. NiedermanWinthrop-University HospitalMineolaUSA8 aut.State University of New York at Stony BrookStony Brook, New YorkUSA8 aut.Marin H. KollefPulmonary and Critical Care Division, Washington University School of MedicineSt. Louis, MissouriUSA9 aut.Andrew F. ShorrPulmonary and Critical Care Medicine, Washington Hospital CenterWashington, DCUSA10 aut.Patrick C. LeeBaystate Medical CenterSpringfield, MassachusettsUSA11 aut.Arnold L. LentnekWellstar Infectious DiseaseMarietta, Georgia;USA12 aut.Carlos M. LunaDepartment of internal Medicine, Pulmonary Diseases Division, Hospital de Clinicas, Universidad de Buenos AiresGBR13 aut.Jean-Yves FagonAssistance Publique-Hôpitaux de Paris, Université Paris-DescartesParisFRA14 aut.Antoni TorresDivision of Pulmonary Medicine, Clinic Institute of Thorax, Hospital Clinic of Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Ciber de Enfermedades RespiratoriasBarcelonaESP15 aut.Michael M. KittFredric C. GenterTheravance Inc.South San Francisco, CaliforniaUSA17 aut.18 aut.Steven L. BarriereTheravance Inc.South San Francisco, CaliforniaUSA17 aut.18 aut.H. David FriedlandMartin E. StryjewskiDepartment of Medicine, Duke Clinical Research InstituteUSA2 aut.3 aut.20 aut.Department of Mecicine and Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clinicas Norberto QuirnoBuenos AiresARG20 aut.11-01418362011PASCAL 11-0141836 INISTPascal:11-01418360012381058-4838Clin. infect. dis.Clinical infectious diseasesAntibacterial agentAntibioticComparative studyGram positive bacteriaNosocomial infectionPneumoniaTelavancinVancomycinInfection nosocomialePneumonieTélavancineVancomycineEtude comparativeBactérie Gram positifAntibactérienAntibiotique
Background. Telavancin is a lipoglycopeptide bactericidal against gram-positive pathogens. Methods. Two methodologically identical, double-blind studies (0015 and 0019) were conducted involving patients with hospital-acquired pneumonia (HAP) due to gram-positive pathogens, particularly methicillin-resistant Staphylococcus aureus (MRSA). Patients were randomized 1:1 to telavancin (10 mg/kg every 24 h) or vancomycin (1 g every 12 h) for 7-21 days. The primary end point was clinical response at follow-up/test-of-cure visit. Results. A total of 1503 patients were randomized and received study medication (the all-treated population). In the pooled all-treated population, cure rates with telavancin versus vancomycin were 58.9% versus 59.5% (95% confidence interval [CI] for the difference, -5.6% to 4.3%). In the pooled clinically evaluable population (n = 654), cure rates were 82.4% with telavancin and 80.7% with vancomycin (95% CI for the difference, -4.3% to 7.7%). Treatment with telavancin achieved higher cure rates in patients with monomicrobial S. aureus infection and comparable cure rates in patients with MRSA infection; in patients with mixed gram-positive/ gram-negative infections, cure rates were higher in the vancomycin group. Incidence and types of adverse events were comparable between the treatment groups. Mortality rates for telavancin-treated versus vancomycin-treated patients were 21.5% versus 16.6% (95% CI for the difference, -0.7% to 10.6%) for study 0015 and 18.5% versus 20.6% (95% CI for the difference, -7.8% to 3.5%) for study 0019. Increases in serum creatinine level were more common in the telavancin group (16% vs 10%). Conclusions. The primary end point of the studies was met, indicating that telavancin is noninferior to vancomycin on the basis of clinical response in the treatment of HAP due to gram-positive pathogens.
1058-4838CIDIELClin. infect. dis.521Telavancin versus Vancomycin for Hospital-Acquired Pneumonia due to Gram-positive PathogensRUBINSTEIN (Ethan)LALANI (Tahaniyat)RALPH COREY (G.)KANAFANI (Zeina A.)NANNINI (Esteban C.)ROCHA (Marcelo G.)RAHAV (Galia)NIEDERMAN (Michael S.)KOLLEF (Marin H.)SHORR (Andrew F.)LEE (Patrick C.)LENTNEK (Arnold L.)LUNA (Carlos M.)FAGON (Jean-Yves)TORRES (Antoni)KITT (Michael M.)GENTER (Fredric C.)BARRIERE (Steven L.)FRIEDLAND (H. David)STRYJEWSKI (Martin E.)Section of Infectiols Diseases Department of Internal Medicine and Medical Microbiology, University of ManitobaWinnipeg, ManitobaCAN1 aut.Department of Medicine, Duke Clinical Research InstituteUSA2 aut.3 aut.20 aut.Department of Medicine, Division of Infectious Diseases, Duke University Medical CenterDurham, North CarolinaUSA2 aut.3 aut.Winthrop-University HospitalMineolaUSA8 aut.State University of New York at Stony BrookStony Brook, New YorkUSA8 aut.Pulmonary and Critical Care Division, Washington University School of MedicineSt. Louis, MissouriUSA9 aut.Pulmonary and Critical Care Medicine, Washington Hospital CenterWashington, DCUSA10 aut.Baystate Medical CenterSpringfield, MassachusettsUSA11 aut.Wellstar Infectious DiseaseMarietta, Georgia;USA12 aut.Theravance Inc.South San Francisco, CaliforniaUSA17 aut.18 aut.American University of Beirut Medical CenterBeirutLBN4 aut.Department of Infectious Diseases, School of Medicine, Universidad Nacional de RosarioRosarioUSA5 aut.Department of internal Medicine, Pulmonary Diseases Division, Hospital de Clinicas, Universidad de Buenos AiresGBR13 aut.Department of Mecicine and Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clinicas Norberto QuirnoBuenos AiresARG20 aut.Intensive Care Unit, Paviihão Pereira Filho, Irmandade da Santa CasaPorto AlegreBRA6 aut.Division of Infectious Diseases Department of Medicine, Sheba Medical CenterTel HashomerISR7 aut.Assistance Publique-Hôpitaux de Paris, Université Paris-DescartesParisFRA14 aut.Division of Pulmonary Medicine, Clinic Institute of Thorax, Hospital Clinic of Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Ciber de Enfermedades RespiratoriasBarcelonaESP15 aut.ATTAIN Study GroupINC31-402011ENGINIST184073540001946265500600000© 2011 INIST-CNRS. All rights reserved.29 ref.11-0141836PAClinical infectious diseasesGBRBackground. Telavancin is a lipoglycopeptide bactericidal against gram-positive pathogens. Methods. Two methodologically identical, double-blind studies (0015 and 0019) were conducted involving patients with hospital-acquired pneumonia (HAP) due to gram-positive pathogens, particularly methicillin-resistant Staphylococcus aureus (MRSA). Patients were randomized 1:1 to telavancin (10 mg/kg every 24 h) or vancomycin (1 g every 12 h) for 7-21 days. The primary end point was clinical response at follow-up/test-of-cure visit. Results. A total of 1503 patients were randomized and received study medication (the all-treated population). In the pooled all-treated population, cure rates with telavancin versus vancomycin were 58.9% versus 59.5% (95% confidence interval [CI] for the difference, -5.6% to 4.3%). In the pooled clinically evaluable population (n = 654), cure rates were 82.4% with telavancin and 80.7% with vancomycin (95% CI for the difference, -4.3% to 7.7%). Treatment with telavancin achieved higher cure rates in patients with monomicrobial S. aureus infection and comparable cure rates in patients with MRSA infection; in patients with mixed gram-positive/ gram-negative infections, cure rates were higher in the vancomycin group. Incidence and types of adverse events were comparable between the treatment groups. Mortality rates for telavancin-treated versus vancomycin-treated patients were 21.5% versus 16.6% (95% CI for the difference, -0.7% to 10.6%) for study 0015 and 18.5% versus 20.6% (95% CI for the difference, -7.8% to 3.5%) for study 0019. Increases in serum creatinine level were more common in the telavancin group (16% vs 10%). Conclusions. The primary end point of the studies was met, indicating that telavancin is noninferior to vancomycin on the basis of clinical response in the treatment of HAP due to gram-positive pathogens.002B05A03002B11D002B02S02Infection nosocomialeNM01Nosocomial infectionNM01Infección nosocomialNM01Pneumonie02Pneumonia02Neumonía02TélavancineFR04TelavancinFR04TelavancinaFR04VancomycineNKFR05VancomycinNKFR05VancomicinaNKFR05Etude comparative07Comparative study07Estudio comparativo07Bactérie Gram positif08Gram positive bacteria08Bacteria Gram positiva08Antibactérien30Antibacterial agent30Antibacteriano30Antibiotique31Antibiotic31Antibiótico31Glycopeptide37Glycopeptide37Glicopéptido37Peptide38Peptides38Péptido38Polypeptide39Polypeptide39Polipéptido39Pathologie de l'appareil respiratoire40Respiratory disease40Aparato respiratorio patología40Pathologie des poumons41Lung disease41Pulmón patología41094OTOOTOPASCAL 11-0141836 INISTTelavancin versus Vancomycin for Hospital-Acquired Pneumonia due to Gram-positive PathogensRUBINSTEIN (Ethan); LALANI (Tahaniyat); RALPH COREY (G.); KANAFANI (Zeina A.); NANNINI (Esteban C.); ROCHA (Marcelo G.); RAHAV (Galia); NIEDERMAN (Michael S.); KOLLEF (Marin H.); SHORR (Andrew F.); LEE (Patrick C.); LENTNEK (Arnold L.); LUNA (Carlos M.); FAGON (Jean-Yves); TORRES (Antoni); KITT (Michael M.); GENTER (Fredric C.); BARRIERE (Steven L.); FRIEDLAND (H. David); STRYJEWSKI (Martin E.)Section of Infectiols Diseases Department of Internal Medicine and Medical Microbiology, University of Manitoba/Winnipeg, Manitoba/Canada (1 aut.); Department of Medicine, Duke Clinical Research Institute/Etats-Unis (2 aut., 3 aut., 20 aut.); Department of Medicine, Division of Infectious Diseases, Duke University Medical Center/Durham, North Carolina/Etats-Unis (2 aut., 3 aut.); Winthrop-University Hospital/Mineola/Etats-Unis (8 aut.); State University of New York at Stony Brook/Stony Brook, New York/Etats-Unis (8 aut.); Pulmonary and Critical Care Division, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (9 aut.); Pulmonary and Critical Care Medicine, Washington Hospital Center/Washington, DC/Etats-Unis (10 aut.); Baystate Medical Center/Springfield, Massachusetts/Etats-Unis (11 aut.); Wellstar Infectious Disease/Marietta, Georgia;/Etats-Unis (12 aut.); Theravance Inc./South San Francisco, California/Etats-Unis (17 aut., 18 aut.); American University of Beirut Medical Center/Beirut/Liban (4 aut.); Department of Infectious Diseases, School of Medicine, Universidad Nacional de Rosario/Rosario/Etats-Unis (5 aut.); Department of internal Medicine, Pulmonary Diseases Division, Hospital de Clinicas, Universidad de Buenos Aires/Royaume-Uni (13 aut.); Department of Mecicine and Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clinicas Norberto Quirno/Buenos Aires/Argentine (20 aut.); Intensive Care Unit, Paviihão Pereira Filho, Irmandade da Santa Casa/Porto Alegre/Brésil (6 aut.); Division of Infectious Diseases Department of Medicine, Sheba Medical Center/Tel Hashomer/Israël (7 aut.); Assistance Publique-Hôpitaux de Paris, Université Paris-Descartes/Paris/France (14 aut.); Division of Pulmonary Medicine, Clinic Institute of Thorax, Hospital Clinic of Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Ciber de Enfermedades Respiratorias/Barcelona/Espagne (15 aut.)
Publication en série; Niveau analytique
Clinical infectious diseases; ISSN 1058-4838; Coden CIDIEL; Royaume-Uni; Da. 2011; Vol. 52; No. 1; Pp. 31-40; Bibl. 29 ref.AnglaisBackground. Telavancin is a lipoglycopeptide bactericidal against gram-positive pathogens. Methods. Two methodologically identical, double-blind studies (0015 and 0019) were conducted involving patients with hospital-acquired pneumonia (HAP) due to gram-positive pathogens, particularly methicillin-resistant Staphylococcus aureus (MRSA). Patients were randomized 1:1 to telavancin (10 mg/kg every 24 h) or vancomycin (1 g every 12 h) for 7-21 days. The primary end point was clinical response at follow-up/test-of-cure visit. Results. A total of 1503 patients were randomized and received study medication (the all-treated population). In the pooled all-treated population, cure rates with telavancin versus vancomycin were 58.9% versus 59.5% (95% confidence interval [CI] for the difference, -5.6% to 4.3%). In the pooled clinically evaluable population (n = 654), cure rates were 82.4% with telavancin and 80.7% with vancomycin (95% CI for the difference, -4.3% to 7.7%). Treatment with telavancin achieved higher cure rates in patients with monomicrobial S. aureus infection and comparable cure rates in patients with MRSA infection; in patients with mixed gram-positive/ gram-negative infections, cure rates were higher in the vancomycin group. Incidence and types of adverse events were comparable between the treatment groups. Mortality rates for telavancin-treated versus vancomycin-treated patients were 21.5% versus 16.6% (95% CI for the difference, -0.7% to 10.6%) for study 0015 and 18.5% versus 20.6% (95% CI for the difference, -7.8% to 3.5%) for study 0019. Increases in serum creatinine level were more common in the telavancin group (16% vs 10%). Conclusions. The primary end point of the studies was met, indicating that telavancin is noninferior to vancomycin on the basis of clinical response in the treatment of HAP due to gram-positive pathogens.002B05A03; 002B11D; 002B02S02Infection nosocomiale; Pneumonie; Télavancine; Vancomycine; Etude comparative; Bactérie Gram positif; Antibactérien; AntibiotiqueGlycopeptide; Peptide; Polypeptide; Pathologie de l'appareil respiratoire; Pathologie des poumonsNosocomial infection; Pneumonia; Telavancin; Vancomycin; Comparative study; Gram positive bacteria; Antibacterial agent; AntibioticGlycopeptide; Peptides; Polypeptide; Respiratory disease; Lung diseaseInfección nosocomial; Neumonía; Telavancina; Vancomicina; Estudio comparativo; Bacteria Gram positiva; Antibacteriano; AntibióticoINIST-18407.35400019462655006011-0141836 001661 Polythiophene thin films electrochemically deposited on sol-gel based TiO<sub>2</sub> for photovoltaic applicationsR. ValaskiDivisão de Metrologia de Materiais (DIMAT), INMETROXerém-Duque de Caxias, RJ 25250BRA1 aut.6 aut.7 aut.8 aut.10 aut.N. A. D. YamamotoDepartamento de Física, Universidade Federal do Paraná, C. Postal 1909981531-990, Curitiba, PRBRA2 aut.3 aut.9 aut.C. D. CanestraroDepartamento de Física, Universidade Federal do Paraná, C. Postal 1909981531-990, Curitiba, PRBRA2 aut.3 aut.9 aut.L. MicaroniDepartamento de Química, Universidade Federal do Paraná, C. Postal 1908181531-990, Curitiba, PRBRA4 aut.5 aut.R. M. Q MelloDepartamento de Química, Universidade Federal do Paraná, C. Postal 1908181531-990, Curitiba, PRBRA4 aut.5 aut.W. G. QuirinoDivisão de Metrologia de Materiais (DIMAT), INMETROXerém-Duque de Caxias, RJ 25250BRA1 aut.6 aut.7 aut.8 aut.10 aut.C. LeganiDivisão de Metrologia de Materiais (DIMAT), INMETROXerém-Duque de Caxias, RJ 25250BRA1 aut.6 aut.7 aut.8 aut.10 aut.C. A. AcheteDivisão de Metrologia de Materiais (DIMAT), INMETROXerém-Duque de Caxias, RJ 25250BRA1 aut.6 aut.7 aut.8 aut.10 aut.L. S. RomanDepartamento de Física, Universidade Federal do Paraná, C. Postal 1909981531-990, Curitiba, PRBRA2 aut.3 aut.9 aut.M. CremonaDivisão de Metrologia de Materiais (DIMAT), INMETROXerém-Duque de Caxias, RJ 25250BRA1 aut.6 aut.7 aut.8 aut.10 aut.Departamento de Física, Pontificia Universidade Católica do Rio de Janeiro22453-970, RJBRA10 aut.11-01420592010PASCAL 11-0142059 INISTPascal:11-01420590012370040-6090Thin solid filmsThin solid filmsAND circuitAnnealingControlled atmospheresCurrent densityElectric field effectsElectrical conductivityElectrodepositionElectron mobilityFluorine additionsInterface phenomenaInterfacesMorphologyPhotovoltaic cellQuantum yieldRadiation effectsSol-gel processTemperature dependenceThick filmsThin filmsThiophene derivative polymerTin additionsTitanium oxideVolatile organic compoundCouche minceDépôt électrolytiqueProcédé sol gelDispositif photovoltaïqueRecuitDépendance températureMobilité électronConductivité électriqueAtmosphère contrôléeCouche épaisseAddition fluorAddition étainMorphologieRendement quantiqueThiophène dérivé polymèreOxyde de titaneComposé organique volatilEffet rayonnementCircuit ETDensité courantInterfacePhénomène interfaceEffet champ électriqueTiO28115P8115L8460J7320
In this work, the influence of titanium dioxide (TiO2) thin films on the efficiency of organic photovoltaic devices based on electrochemically synthesized polythiophene (PT) was investigated. TiO2 films were produced by sol-gel methods with controlled thickness. The best TiO2 annealing condition was determined through the investigation of the temperature influence on the electron charge mobility and resistivity in a range between 723 K and 923 K. The PT films were produced by chronoamperometric method in a 3-electrode cell under a controlled atmosphere. High quality PT films were produced onto 40 nm thick TiO2 layer previously deposited onto fluorine doped tin oxide (FTO) substrate. The morphology of PT films grown on both substrates and its strong influence on the device performance and PT minimum thickness were also investigated. The maximum external quantum efficiency (IPCE) reached was 9% under monochromatic irradiation (λ = 610 nm; 1 W/m2) that is three orders of magnitude higher than that presented by PT-homolayer devices with similar PT thickness. In addition, the open-circuit voltage (Voc) was about 700 mV and the short-circuit current density (Jsc) was 0.03 A/m2 (λ = 610 nm; 7 W/m2). However, as for the PT-homolayer also the TiO2/PT based devices are characterized by antibatic response when illuminated through FTO. Finally, the Fill Factor (FF) of these devices is low (25%), indicating that the series resistance (Rs), which is strongly dependent of the PT thickness, is too large. This large Rs value is compensated by TiO2/PT interface morphology and by FTO/TiO2 and TiO2/PT interface phenomena producing preferential paths in which the internal electrical field is higher, improving the device efficiency.
0040-6090THSFAPThin solid films5195Polythiophene thin films electrochemically deposited on sol-gel based TiO2 for photovoltaic applicationsProceedings of the 37th International Conference on Metallurgical Coatings and Thin Films (ICMCTF), San Diego, California (USA), April 26 - April 30, 2010VALASKI (R.)YAMAMOTO (N. A. D.)CANESTRARO (C. D.)MICARONI (L.)MELLO (R. M. Q)QUIRINO (W. G.)LEGANI (C.)ACHETE (C. A.)ROMAN (L. S.)CREMONA (M.)ABADIAS (Gregory)ed.MURATORE (Chris)ed.PETROV (Ivan)ed.REBHOLZ (Claus)ed.SCHEIBE (Hans-Joachim)ed.STÜBER (Michael)ed.Divisão de Metrologia de Materiais (DIMAT), INMETROXerém-Duque de Caxias, RJ 25250BRA1 aut.6 aut.7 aut.8 aut.10 aut.Departamento de Física, Universidade Federal do Paraná, C. Postal 1909981531-990, Curitiba, PRBRA2 aut.3 aut.9 aut.Departamento de Química, Universidade Federal do Paraná, C. Postal 1908181531-990, Curitiba, PRBRA4 aut.5 aut.Departamento de Física, Pontificia Universidade Católica do Rio de Janeiro22453-970, RJBRA10 aut.University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS86982 Chasseneuil FuturoscopeFRA1 aut.Materials and Manufacturing Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136Wright Patterson AFB, OH 45433USA2 aut.University of Cyprus Mechanical & Manufacturing Engineering 75 Kallipoleos Street1678 NicosiaCYP4 aut.Fraunhofer IWS Dresden Winterbergstrasse 2801277 DresdenDEU5 aut.Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 176344 Eggenstein-LeopoldshafenDEU6 aut.1511-15152010ENGINIST135973540001943776400500000© 2011 INIST-CNRS. All rights reserved.44 ref.11-0142059PCAThin solid filmsNLDIn this work, the influence of titanium dioxide (TiO2) thin films on the efficiency of organic photovoltaic devices based on electrochemically synthesized polythiophene (PT) was investigated. TiO2 films were produced by sol-gel methods with controlled thickness. The best TiO2 annealing condition was determined through the investigation of the temperature influence on the electron charge mobility and resistivity in a range between 723 K and 923 K. The PT films were produced by chronoamperometric method in a 3-electrode cell under a controlled atmosphere. High quality PT films were produced onto 40 nm thick TiO2 layer previously deposited onto fluorine doped tin oxide (FTO) substrate. The morphology of PT films grown on both substrates and its strong influence on the device performance and PT minimum thickness were also investigated. The maximum external quantum efficiency (IPCE) reached was 9% under monochromatic irradiation (λ = 610 nm; 1 W/m2) that is three orders of magnitude higher than that presented by PT-homolayer devices with similar PT thickness. In addition, the open-circuit voltage (Voc) was about 700 mV and the short-circuit current density (Jsc) was 0.03 A/m2 (λ = 610 nm; 7 W/m2). However, as for the PT-homolayer also the TiO2/PT based devices are characterized by antibatic response when illuminated through FTO. Finally, the Fill Factor (FF) of these devices is low (25%), indicating that the series resistance (Rs), which is strongly dependent of the PT thickness, is too large. This large Rs value is compensated by TiO2/PT interface morphology and by FTO/TiO2 and TiO2/PT interface phenomena producing preferential paths in which the internal electrical field is higher, improving the device efficiency.001B80A15P001B80A15L001D06C02D1001B70C20230Couche mince01Thin films01Dépôt électrolytique02Electrodeposition02Procédé sol gel03Sol-gel process03Dispositif photovoltaïque04Photovoltaic cell04Dispositivo fotovoltaico04Recuit05Annealing05Dépendance température06Temperature dependence06Mobilité électron07Electron mobility07Conductivité électrique08Electrical conductivity08Atmosphère contrôlée09Controlled atmospheres09Couche épaisse10Thick films10Addition fluor11Fluorine additions11Addition étain12Tin additions12Morphologie13Morphology13Rendement quantique14Quantum yield14Thiophène dérivé polymèreNK15Thiophene derivative polymerNK15Tiofeno derivado polímeroNK15Oxyde de titane16Titanium oxide16Titanio óxido16Composé organique volatil17Volatile organic compound17Compuesto orgánico volátil17Effet rayonnement29Radiation effects29Circuit ET30AND circuit30Circuito Y30Densité courant31Current density31Interface32Interfaces32Phénomène interface33Interface phenomena33Effet champ électrique34Electric field effects34TiO2INC468115PINC718115LINC728460JINC737320INC74094OTOOTOInternational Conference of Metallurgical Coatings and Thin Films (ICMCTF)37San Diego, California USA2010-04-26PASCAL 11-0142059 INISTPolythiophene thin films electrochemically deposited on sol-gel based TiO2 for photovoltaic applicationsVALASKI (R.); YAMAMOTO (N. A. D.); CANESTRARO (C. D.); MICARONI (L.); MELLO (R. M. Q); QUIRINO (W. G.); LEGANI (C.); ACHETE (C. A.); ROMAN (L. S.); CREMONA (M.); ABADIAS (Gregory); MURATORE (Chris); PETROV (Ivan); REBHOLZ (Claus); SCHEIBE (Hans-Joachim); STÜBER (Michael)Divisão de Metrologia de Materiais (DIMAT), INMETRO/Xerém-Duque de Caxias, RJ 25250/Brésil (1 aut., 6 aut., 7 aut., 8 aut., 10 aut.); Departamento de Física, Universidade Federal do Paraná, C. Postal 19099/81531-990, Curitiba, PR/Brésil (2 aut., 3 aut., 9 aut.); Departamento de Química, Universidade Federal do Paraná, C. Postal 19081/81531-990, Curitiba, PR/Brésil (4 aut., 5 aut.); Departamento de Física, Pontificia Universidade Católica do Rio de Janeiro/22453-970, RJ/Brésil (10 aut.); University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS/86982 Chasseneuil Futuroscope/France (1 aut.); Materials and Manufacturing Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136/Wright Patterson AFB, OH 45433/Etats-Unis (2 aut.); University of Cyprus Mechanical & Manufacturing Engineering 75 Kallipoleos Street/1678 Nicosia/Chypre (4 aut.); Fraunhofer IWS Dresden Winterbergstrasse 28/01277 Dresden/Allemagne (5 aut.); Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 1/76344 Eggenstein-Leopoldshafen/Allemagne (6 aut.)
Publication en série; Congrès; Niveau analytique
Thin solid films; ISSN 0040-6090; Coden THSFAP; Pays-Bas; Da. 2010; Vol. 519; No. 5; Pp. 1511-1515; Bibl. 44 ref.AnglaisIn this work, the influence of titanium dioxide (TiO2) thin films on the efficiency of organic photovoltaic devices based on electrochemically synthesized polythiophene (PT) was investigated. TiO2 films were produced by sol-gel methods with controlled thickness. The best TiO2 annealing condition was determined through the investigation of the temperature influence on the electron charge mobility and resistivity in a range between 723 K and 923 K. The PT films were produced by chronoamperometric method in a 3-electrode cell under a controlled atmosphere. High quality PT films were produced onto 40 nm thick TiO2 layer previously deposited onto fluorine doped tin oxide (FTO) substrate. The morphology of PT films grown on both substrates and its strong influence on the device performance and PT minimum thickness were also investigated. The maximum external quantum efficiency (IPCE) reached was 9% under monochromatic irradiation (λ = 610 nm; 1 W/m2) that is three orders of magnitude higher than that presented by PT-homolayer devices with similar PT thickness. In addition, the open-circuit voltage (Voc) was about 700 mV and the short-circuit current density (Jsc) was 0.03 A/m2 (λ = 610 nm; 7 W/m2). However, as for the PT-homolayer also the TiO2/PT based devices are characterized by antibatic response when illuminated through FTO. Finally, the Fill Factor (FF) of these devices is low (25%), indicating that the series resistance (Rs), which is strongly dependent of the PT thickness, is too large. This large Rs value is compensated by TiO2/PT interface morphology and by FTO/TiO2 and TiO2/PT interface phenomena producing preferential paths in which the internal electrical field is higher, improving the device efficiency.001B80A15P; 001B80A15L; 001D06C02D1; 001B70C20; 230Couche mince; Dépôt électrolytique; Procédé sol gel; Dispositif photovoltaïque; Recuit; Dépendance température; Mobilité électron; Conductivité électrique; Atmosphère contrôlée; Couche épaisse; Addition fluor; Addition étain; Morphologie; Rendement quantique; Thiophène dérivé polymère; Oxyde de titane; Composé organique volatil; Effet rayonnement; Circuit ET; Densité courant; Interface; Phénomène interface; Effet champ électrique; TiO2; 8115P; 8115L; 8460J; 7320Thin films; Electrodeposition; Sol-gel process; Photovoltaic cell; Annealing; Temperature dependence; Electron mobility; Electrical conductivity; Controlled atmospheres; Thick films; Fluorine additions; Tin additions; Morphology; Quantum yield; Thiophene derivative polymer; Titanium oxide; Volatile organic compound; Radiation effects; AND circuit; Current density; Interfaces; Interface phenomena; Electric field effectsDispositivo fotovoltaico; Tiofeno derivado polímero; Titanio óxido; Compuesto orgánico volátil; Circuito YINIST-13597.35400019437764005011-0142059 001662 The Influence of Geometrical and Mechanical Input Parameters on Theoretical Models of PhonationJ. CisonniGIPSA-lab, UMR CNRS 5216, Grenoble UniversitiesFRA1 aut.2 aut.3 aut.A. Van HirtumGIPSA-lab, UMR CNRS 5216, Grenoble UniversitiesFRA1 aut.2 aut.3 aut.X. PelorsonGIPSA-lab, UMR CNRS 5216, Grenoble UniversitiesFRA1 aut.2 aut.3 aut.J. LuceroUniversity of BrasiliaBRA4 aut.11-01424392011PASCAL 11-0142439 INISTPascal:11-01424390012361610-1928Acta acustica united with acusticaDeformation modulusElastic constantExperimental studyFrequency responseGeometrical parameterHumanInitial conditionMechanical propertiesModelingPerception thresholdPhonationPressure fluctuationReduced order systemsVocal cordVocal tractYoung modulusPhonationPropriété mécaniqueFluctuation pressionCorde vocaleConstante élasticitéModule déformationModule YoungParamètre géométriqueSeuil perceptionCanal vocalHommeRéponse fréquenceModélisationCondition initialeSystème ordre réduitEtude expérimentale
The influence of initial aperture and mechanical properties on the onset pressure thresholds and oscillation frequencies is experimentally assessed on a deformable vocal fold replica in case of strong and weak acoustical coupling. The mechanical replica enables to vary the initial aperture while mechanical properties are maintained and therefore to mimic abduction and adduction gestures of human phonation. Depending on initial conditions (geometrical, mechanical and acoustical) one or two oscillation regions are experimentally found for which important differences are observed for both oscillation onset pressure thresholds and oscillation frequencies. Measured onset pressure thresholds are used to validate the outcome of a theoretical model of phonation using a reduced mechanical model. The applied coupling stiffness in the theoretical model is estimated from the measured frequency response instead of imposed by an 'ad-hoc' criterion. The variations in coupling stiffness result in a qualitative agreement between predicted and measured values for all assessed experimental conditions. In addition, the Young's modulus of the replica is qualitatively estimated to be within the range observed 'in-vivo'.
1610-1928972The Influence of Geometrical and Mechanical Input Parameters on Theoretical Models of PhonationCISONNI (J.)VAN HIRTUM (A.)PELORSON (X.)LUCERO (J.)GIPSA-lab, UMR CNRS 5216, Grenoble UniversitiesFRA1 aut.2 aut.3 aut.University of BrasiliaBRA4 aut.291-3022011ENGINIST68273540001907274401300000© 2011 INIST-CNRS. All rights reserved.26 ref.11-0142439PAActa acustica united with acusticaDEUThe influence of initial aperture and mechanical properties on the onset pressure thresholds and oscillation frequencies is experimentally assessed on a deformable vocal fold replica in case of strong and weak acoustical coupling. The mechanical replica enables to vary the initial aperture while mechanical properties are maintained and therefore to mimic abduction and adduction gestures of human phonation. Depending on initial conditions (geometrical, mechanical and acoustical) one or two oscillation regions are experimentally found for which important differences are observed for both oscillation onset pressure thresholds and oscillation frequencies. Measured onset pressure thresholds are used to validate the outcome of a theoretical model of phonation using a reduced mechanical model. The applied coupling stiffness in the theoretical model is estimated from the measured frequency response instead of imposed by an 'ad-hoc' criterion. The variations in coupling stiffness result in a qualitative agreement between predicted and measured values for all assessed experimental conditions. In addition, the Young's modulus of the replica is qualitatively estimated to be within the range observed 'in-vivo'.002A25HPhonation06Phonation06Fonación06Propriété mécanique07Mechanical properties07Propiedad mecánica07Fluctuation pression08Pressure fluctuation08Fluctuación presión08Corde vocale09Vocal cord09Cuerda vocal09Constante élasticité10Elastic constant10Constante elasticidad10Module déformation11Deformation modulus11Módulo deformación11Module Young12Young modulus12Módulo Young12Paramètre géométrique15Geometrical parameter15Parámetro geométrico15Seuil perception16Perception threshold16Umbral percepción16Canal vocal17Vocal tract17Conducto vocal17Homme18Human18Hombre18Réponse fréquence19Frequency response19Respuesta frecuencia19Modélisation23Modeling23Modelización23Condition initiale24Initial condition24Condición inicial24Système ordre réduit25Reduced order systems25Etude expérimentale33Experimental study33Estudio experimental33094OTOOTOPASCAL 11-0142439 INISTThe Influence of Geometrical and Mechanical Input Parameters on Theoretical Models of PhonationCISONNI (J.); VAN HIRTUM (A.); PELORSON (X.); LUCERO (J.)GIPSA-lab, UMR CNRS 5216, Grenoble Universities/France (1 aut., 2 aut., 3 aut.); University of Brasilia/Brésil (4 aut.)
Publication en série; Niveau analytique
Acta acustica united with acustica; ISSN 1610-1928; Allemagne; Da. 2011; Vol. 97; No. 2; Pp. 291-302; Bibl. 26 ref.AnglaisThe influence of initial aperture and mechanical properties on the onset pressure thresholds and oscillation frequencies is experimentally assessed on a deformable vocal fold replica in case of strong and weak acoustical coupling. The mechanical replica enables to vary the initial aperture while mechanical properties are maintained and therefore to mimic abduction and adduction gestures of human phonation. Depending on initial conditions (geometrical, mechanical and acoustical) one or two oscillation regions are experimentally found for which important differences are observed for both oscillation onset pressure thresholds and oscillation frequencies. Measured onset pressure thresholds are used to validate the outcome of a theoretical model of phonation using a reduced mechanical model. The applied coupling stiffness in the theoretical model is estimated from the measured frequency response instead of imposed by an 'ad-hoc' criterion. The variations in coupling stiffness result in a qualitative agreement between predicted and measured values for all assessed experimental conditions. In addition, the Young's modulus of the replica is qualitatively estimated to be within the range observed 'in-vivo'.002A25HPhonation; Propriété mécanique; Fluctuation pression; Corde vocale; Constante élasticité; Module déformation; Module Young; Paramètre géométrique; Seuil perception; Canal vocal; Homme; Réponse fréquence; Modélisation; Condition initiale; Système ordre réduit; Etude expérimentalePhonation; Mechanical properties; Pressure fluctuation; Vocal cord; Elastic constant; Deformation modulus; Young modulus; Geometrical parameter; Perception threshold; Vocal tract; Human; Frequency response; Modeling; Initial condition; Reduced order systems; Experimental studyFonación; Propiedad mecánica; Fluctuación presión; Cuerda vocal; Constante elasticidad; Módulo deformación; Módulo Young; Parámetro geométrico; Umbral percepción; Conducto vocal; Hombre; Respuesta frecuencia; Modelización; Condición inicial; Estudio experimentalINIST-6827.35400019072744013011-0142439 001663 Citrus Sudden Death Is Transmitted by Graft-Inoculation and Natural Transmission Is Prevented by Individual Insect-Proof CagesPedro T. YamamotoDepartamento Científico, Fundo de Defesa da Citricultura, Fundecitrus, Av. Dr. Adhemar Pereira de Barros, 201, CEP 14807-040Araraquara - SPBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.Renato B. BassaneziDepartamento Científico, Fundo de Defesa da Citricultura, Fundecitrus, Av. Dr. Adhemar Pereira de Barros, 201, CEP 14807-040Araraquara - SPBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.Nelson A. WulffDepartamento Científico, Fundo de Defesa da Citricultura, Fundecitrus, Av. Dr. Adhemar Pereira de Barros, 201, CEP 14807-040Araraquara - SPBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.Mateus A. SantosDepartamento Científico, Fundo de Defesa da Citricultura, Fundecitrus, Av. Dr. Adhemar Pereira de Barros, 201, CEP 14807-040Araraquara - SPBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.André L. SanchesDepartamento Científico, Fundo de Defesa da Citricultura, Fundecitrus, Av. Dr. Adhemar Pereira de Barros, 201, CEP 14807-040Araraquara - SPBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.Rodrigo S. ToloyDepartamento Científico, Fundo de Defesa da Citricultura, Fundecitrus, Av. Dr. Adhemar Pereira de Barros, 201, CEP 14807-040Araraquara - SPBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.Nelson Gimenes-FernandesDepartamento Científico, Fundo de Defesa da Citricultura, Fundecitrus, Av. Dr. Adhemar Pereira de Barros, 201, CEP 14807-040Araraquara - SPBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.Antonio J. AyresDepartamento Científico, Fundo de Defesa da Citricultura, Fundecitrus, Av. Dr. Adhemar Pereira de Barros, 201, CEP 14807-040Araraquara - SPBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.Waldir C. Jesus JuniorLaboratório de Fitopatologia, Departamento de Fitotecnia, Universidade Federal do Espirito Santo, Alto Universitário, S/N, CEP 29500-000Alegre - ESBRA9 aut.Tatsuya NagataDepartamento de Biologia Celular, IB4, Universidade de Brasília, ICC Ala Sul, Asa Norte, CEP 70910-900Brasília - DFBRA10 aut.Francisco A. O. TanakaNAP/MEPA, Escola Superior de Agricultura "Luiz de Queiroz", Universidade de Sao Paulo, Av. Padua Dias, 11, CEP 13418-900Piracicaba - SPBRA11 aut.12 aut.Elliot W. KitajimaNAP/MEPA, Escola Superior de Agricultura "Luiz de Queiroz", Universidade de Sao Paulo, Av. Padua Dias, 11, CEP 13418-900Piracicaba - SPBRA11 aut.12 aut.Joseph M. BoveUnite Mixte de Recherche en Genomique, Développement et Pouvoir Pathogène, Centre de Recherche INRA de Bordeaux, 71, Ave. Edouard Bourlaux33883 Villenave d'OrnonFRA13 aut.11-01438122011PASCAL 11-0143812 INISTPascal:11-01438120012350191-2917Plant dis.Plant diseaseCitrusGraftInsectaPlantPlant pathogenPlant pathologyTransmissionCitrusInsectaGreffeTransmissionPhytopathologiePhytopathogènePlante
Citrus sudden death (CSD) transmission was studied by graft-inoculation and under natural conditions. Young sweet orange trees on Rangpur rootstock were used as indicator plants. They were examined regularly for one or two characteristic markers of CSD: (i) presence of a yellow-stained layer of thickened bark on the Rangpur rootstock, and (ii) infection with the CSD-associated marafivirus. Based on these two markers, transmission of CSD was obtained, not only when budwood for graft-inoculation was taken from symptomatic, sweet orange trees on Rangpur, but also when the budwood sources were asymptomatic sweet orange trees on Cleopatra mandarin, indicating that the latter trees are symptomless carriers of the CSD agent. For natural transmission, 80 young indicator plants were planted within a citrus plot severely affected by CSD. Individual insect-proof cages were built around 40 indicator plants, and the other 40 indicator plants remained uncaged. Only two of the 40 caged indicator plants were affected by CSD, whereas 17 uncaged indicator plants showed CSD symptoms and were infected with the marafivirus. An additional 12 uncaged indicator plants became severely affected with citrus variegated chlorosis and were removed. These results strongly suggest that under natural conditions, CSD is transmitted by an aerial vector, such as an insect, and that the cages protected the trees against infection by the vector.
0191-2917PLDIDEPlant dis.952Citrus Sudden Death Is Transmitted by Graft-Inoculation and Natural Transmission Is Prevented by Individual Insect-Proof CagesYAMAMOTO (Pedro T.)BASSANEZI (Renato B.)WULFF (Nelson A.)SANTOS (Mateus A.)SANCHES (André L.)TOLOY (Rodrigo S.)GIMENES-FERNANDES (Nelson)AYRES (Antonio J.)JESUS JUNIOR (Waldir C.)NAGATA (Tatsuya)TANAKA (Francisco A. O.)KITAJIMA (Elliot W.)BOVE (Joseph M.)Departamento Científico, Fundo de Defesa da Citricultura, Fundecitrus, Av. Dr. Adhemar Pereira de Barros, 201, CEP 14807-040Araraquara - SPBRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.Laboratório de Fitopatologia, Departamento de Fitotecnia, Universidade Federal do Espirito Santo, Alto Universitário, S/N, CEP 29500-000Alegre - ESBRA9 aut.Departamento de Biologia Celular, IB4, Universidade de Brasília, ICC Ala Sul, Asa Norte, CEP 70910-900Brasília - DFBRA10 aut.NAP/MEPA, Escola Superior de Agricultura "Luiz de Queiroz", Universidade de Sao Paulo, Av. Padua Dias, 11, CEP 13418-900Piracicaba - SPBRA11 aut.12 aut.Unite Mixte de Recherche en Genomique, Développement et Pouvoir Pathogène, Centre de Recherche INRA de Bordeaux, 71, Ave. Edouard Bourlaux33883 Villenave d'OrnonFRA13 aut.104-1122011ENGINIST126733540001946274700200000© 2011 INIST-CNRS. All rights reserved.21 ref.11-0143812PAPlant diseaseUSACitrus sudden death (CSD) transmission was studied by graft-inoculation and under natural conditions. Young sweet orange trees on Rangpur rootstock were used as indicator plants. They were examined regularly for one or two characteristic markers of CSD: (i) presence of a yellow-stained layer of thickened bark on the Rangpur rootstock, and (ii) infection with the CSD-associated marafivirus. Based on these two markers, transmission of CSD was obtained, not only when budwood for graft-inoculation was taken from symptomatic, sweet orange trees on Rangpur, but also when the budwood sources were asymptomatic sweet orange trees on Cleopatra mandarin, indicating that the latter trees are symptomless carriers of the CSD agent. For natural transmission, 80 young indicator plants were planted within a citrus plot severely affected by CSD. Individual insect-proof cages were built around 40 indicator plants, and the other 40 indicator plants remained uncaged. Only two of the 40 caged indicator plants were affected by CSD, whereas 17 uncaged indicator plants showed CSD symptoms and were infected with the marafivirus. An additional 12 uncaged indicator plants became severely affected with citrus variegated chlorosis and were removed. These results strongly suggest that under natural conditions, CSD is transmitted by an aerial vector, such as an insect, and that the cages protected the trees against infection by the vector.002A34CitrusNS01CitrusNS01CitrusNS01InsectaNS02InsectaNS02InsectaNS02Greffe05Graft05Injerto05Transmission06Transmission06Transmisión06Phytopathologie07Plant pathology07Fitopatología07Phytopathogène08Plant pathogen08Fitopatógeno08Plante45Plant45Planta45RutaceaeNSRutaceaeNSRutaceaeNSDicotyledonesNSDicotyledonesNSDicotyledonesNSAngiospermaeNSAngiospermaeNSAngiospermaeNSSpermatophytaNSSpermatophytaNSSpermatophytaNSArthropodaNSArthropodaNSArthropodaNSInvertebrataNSInvertebrataNSInvertebrataNSAgrume13Citrus fruit13Agrios13094OTOOTOPASCAL 11-0143812 INISTCitrus Sudden Death Is Transmitted by Graft-Inoculation and Natural Transmission Is Prevented by Individual Insect-Proof CagesYAMAMOTO (Pedro T.); BASSANEZI (Renato B.); WULFF (Nelson A.); SANTOS (Mateus A.); SANCHES (André L.); TOLOY (Rodrigo S.); GIMENES-FERNANDES (Nelson); AYRES (Antonio J.); JESUS JUNIOR (Waldir C.); NAGATA (Tatsuya); TANAKA (Francisco A. O.); KITAJIMA (Elliot W.); BOVE (Joseph M.)Departamento Científico, Fundo de Defesa da Citricultura, Fundecitrus, Av. Dr. Adhemar Pereira de Barros, 201, CEP 14807-040/Araraquara - SP/Brésil (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Laboratório de Fitopatologia, Departamento de Fitotecnia, Universidade Federal do Espirito Santo, Alto Universitário, S/N, CEP 29500-000/Alegre - ES/Brésil (9 aut.); Departamento de Biologia Celular, IB4, Universidade de Brasília, ICC Ala Sul, Asa Norte, CEP 70910-900/Brasília - DF/Brésil (10 aut.); NAP/MEPA, Escola Superior de Agricultura "Luiz de Queiroz", Universidade de Sao Paulo, Av. Padua Dias, 11, CEP 13418-900/Piracicaba - SP/Brésil (11 aut., 12 aut.); Unite Mixte de Recherche en Genomique, Développement et Pouvoir Pathogène, Centre de Recherche INRA de Bordeaux, 71, Ave. Edouard Bourlaux/33883 Villenave d'Ornon/France (13 aut.)
Publication en série; Niveau analytique
Plant disease; ISSN 0191-2917; Coden PLDIDE; Etats-Unis; Da. 2011; Vol. 95; No. 2; Pp. 104-112; Bibl. 21 ref.AnglaisCitrus sudden death (CSD) transmission was studied by graft-inoculation and under natural conditions. Young sweet orange trees on Rangpur rootstock were used as indicator plants. They were examined regularly for one or two characteristic markers of CSD: (i) presence of a yellow-stained layer of thickened bark on the Rangpur rootstock, and (ii) infection with the CSD-associated marafivirus. Based on these two markers, transmission of CSD was obtained, not only when budwood for graft-inoculation was taken from symptomatic, sweet orange trees on Rangpur, but also when the budwood sources were asymptomatic sweet orange trees on Cleopatra mandarin, indicating that the latter trees are symptomless carriers of the CSD agent. For natural transmission, 80 young indicator plants were planted within a citrus plot severely affected by CSD. Individual insect-proof cages were built around 40 indicator plants, and the other 40 indicator plants remained uncaged. Only two of the 40 caged indicator plants were affected by CSD, whereas 17 uncaged indicator plants showed CSD symptoms and were infected with the marafivirus. An additional 12 uncaged indicator plants became severely affected with citrus variegated chlorosis and were removed. These results strongly suggest that under natural conditions, CSD is transmitted by an aerial vector, such as an insect, and that the cages protected the trees against infection by the vector.002A34Citrus; Insecta; Greffe; Transmission; Phytopathologie; Phytopathogène; PlanteRutaceae; Dicotyledones; Angiospermae; Spermatophyta; Arthropoda; Invertebrata; AgrumeCitrus; Insecta; Graft; Transmission; Plant pathology; Plant pathogen; PlantRutaceae; Dicotyledones; Angiospermae; Spermatophyta; Arthropoda; Invertebrata; Citrus fruitCitrus; Insecta; Injerto; Transmisión; Fitopatología; Fitopatógeno; PlantaINIST-12673.35400019462747002011-0143812 001664 LA NOUVELLE LOI SUR LA GESTION DES SERVICES D'EAU ET D'ASSAINISSEMENT AU BRÉSIL: Les nouveaux enjeux pour les acteurs publics et pour les acteurs privésAna Lucia BrittoFaculté d'architecture et urbanisme, Université fédérale de Rio de JaneiroBRA1 aut.11-01466002010FRANCIS 11-0146600 INISTFrancis:11-01466000014701293-8882Rev. Tiers mondeRevue Tiers mondeAct of ParliamentBrazilDrainingPrivate EntrepriseState EntrepriseWaterWater administrationGestion de l'eauBrésilLoiAssainissementSecteur publicSecteur privéEau
Au Brésil, les modes de gestion des services d'eau et d'assainissement, structurés dans les années 1970 et restés relativement stables jusqu'à présent, connaissent actuellement des transformations qui découlent de deux nouvelles lois: la loi sur la prestation des services de 2007 et la loi de 2005 qui réglemente la coopération entre les différents acteurs du secteur public. Il y a une nouvelle compétition entre les acteurs publics qui assurent la prestation des services et l'émergence de nouveaux acteurs privés. L'article examine les caractéristiques actuelles de la gestion des services, présente les principales nouveautés qu'apportent les deux lois et discute les nouveaux rapports entre les acteurs du secteur et les nouveaux champs d'action qui sont désormais possibles.
1293-8882Rev. Tiers monde203LA NOUVELLE LOI SUR LA GESTION DES SERVICES D'EAU ET D'ASSAINISSEMENT AU BRÉSIL: Les nouveaux enjeux pour les acteurs publics et pour les acteurs privésEAU DES VILLES : REPENSER DES SERVICES EN MUTATIONBRITTO (Ana Lucia)JAGLIN (Sylvie)ed.ZERAH (Marie-Hélène)ed.Faculté d'architecture et urbanisme, Université fédérale de Rio de JaneiroBRA1 aut.Université Paris-Est Marne-la-ValléeFRA1 aut.Institut de recherche du développement (IRD) en détachement au Centre de sciences humainesNew DelhiIND2 aut.23-39, 227, 230 [19 p.]2010FREengspaINIST268543540001924220600100000© 2011 INIST-CNRS. All rights reserved.1/4 p.11-0146600PARevue Tiers mondeFRAWater Management in Brazilian Cities: New Water Services Law, New Issues and New PlayersAu Brésil, les modes de gestion des services d'eau et d'assainissement, structurés dans les années 1970 et restés relativement stables jusqu'à présent, connaissent actuellement des transformations qui découlent de deux nouvelles lois: la loi sur la prestation des services de 2007 et la loi de 2005 qui réglemente la coopération entre les différents acteurs du secteur public. Il y a une nouvelle compétition entre les acteurs publics qui assurent la prestation des services et l'émergence de nouveaux acteurs privés. L'article examine les caractéristiques actuelles de la gestion des services, présente les principales nouveautés qu'apportent les deux lois et discute les nouveaux rapports entre les acteurs du secteur et les nouveaux champs d'action qui sont désormais possibles.52123V521Gestion de l'eau01Water administration01BrésilNG02BrazilNG02Loi03Act of Parliament03Assainissement04Draining04Secteur public05State Entreprise05Secteur privé06Private Entreprise06Eau07Water07094FRANCIS 11-0146600 INISTLA NOUVELLE LOI SUR LA GESTION DES SERVICES D'EAU ET D'ASSAINISSEMENT AU BRÉSIL: Les nouveaux enjeux pour les acteurs publics et pour les acteurs privés(Water Management in Brazilian Cities: New Water Services Law, New Issues and New Players)BRITTO (Ana Lucia); JAGLIN (Sylvie); ZERAH (Marie-Hélène)Faculté d'architecture et urbanisme, Université fédérale de Rio de Janeiro/Brésil (1 aut.); Université Paris-Est Marne-la-Vallée/France (1 aut.); Institut de recherche du développement (IRD) en détachement au Centre de sciences humaines/New Delhi/Inde (2 aut.)
Publication en série; Niveau analytique
Revue Tiers monde; ISSN 1293-8882; France; Da. 2010; No. 203; 23-39, 227, 230 [19 p.]; Abs. anglais/espagnol; Bibl. 1/4 p.FrançaisAu Brésil, les modes de gestion des services d'eau et d'assainissement, structurés dans les années 1970 et restés relativement stables jusqu'à présent, connaissent actuellement des transformations qui découlent de deux nouvelles lois: la loi sur la prestation des services de 2007 et la loi de 2005 qui réglemente la coopération entre les différents acteurs du secteur public. Il y a une nouvelle compétition entre les acteurs publics qui assurent la prestation des services et l'émergence de nouveaux acteurs privés. L'article examine les caractéristiques actuelles de la gestion des services, présente les principales nouveautés qu'apportent les deux lois et discute les nouveaux rapports entre les acteurs du secteur et les nouveaux champs d'action qui sont désormais possibles.52123; 521Gestion de l'eau; Brésil; Loi; Assainissement; Secteur public; Secteur privé; EauWater administration; Brazil; Act of Parliament; Draining; State Entreprise; Private Entreprise; WaterINIST-26854.35400019242206001011-0146600 001665 Sharp Turan inequalities via very hyperbolic polynomialsDimitar K. DimitrovDepartamento de Ciências de Computação e Estatístiea, IBILCE, Universidade Estadual Paulista15054-000 São José do Rio Preto, SPBRA1 aut.Vladimir P. KostovUniversite de Nice, Laboratoire de Mathématiques, Pare Valrose06108 NiceFRA2 aut.11-01473022011PASCAL 11-0147302 INISTPascal:11-01473020012340022-247XJ. math. anal. appl.Journal of mathematical analysis and applicationsEntire functionMathematical analysisPolynomialAnalyse mathématiquePolynômeFonction entière30Dxx
We present new sharp inequalities for the Maclaurin coefficients of an entire function from the Laguerre-Pólya class. They are obtained by a new technique involving the so-called very hyperbolic polynomials. The results may be considered as extensions of the classical Turan inequalities.
0022-247XJMANAKJ. math. anal. appl.3762Sharp Turan inequalities via very hyperbolic polynomialsDIMITROV (Dimitar K.)KOSTOV (Vladimir P.)Departamento de Ciências de Computação e Estatístiea, IBILCE, Universidade Estadual Paulista15054-000 São José do Rio Preto, SPBRA1 aut.Universite de Nice, Laboratoire de Mathématiques, Pare Valrose06108 NiceFRA2 aut.385-3922011ENGINIST29803540001928035400100000© 2011 INIST-CNRS. All rights reserved.13 ref.11-0147302PAJournal of mathematical analysis and applicationsNLDWe present new sharp inequalities for the Maclaurin coefficients of an entire function from the Laguerre-Pólya class. They are obtained by a new technique involving the so-called very hyperbolic polynomials. The results may be considered as extensions of the classical Turan inequalities.001A02E03Analyse mathématique01Mathematical analysis01Análisis matemático01Polynôme17Polynomial17Polinomio17Fonction entière18Entire function18Función entera1830DxxINC70094OTOOTOPASCAL 11-0147302 INISTSharp Turan inequalities via very hyperbolic polynomialsDIMITROV (Dimitar K.); KOSTOV (Vladimir P.)Departamento de Ciências de Computação e Estatístiea, IBILCE, Universidade Estadual Paulista/15054-000 São José do Rio Preto, SP/Brésil (1 aut.); Universite de Nice, Laboratoire de Mathématiques, Pare Valrose/06108 Nice/France (2 aut.)
Publication en série; Niveau analytique
Journal of mathematical analysis and applications; ISSN 0022-247X; Coden JMANAK; Pays-Bas; Da. 2011; Vol. 376; No. 2; Pp. 385-392; Bibl. 13 ref.AnglaisWe present new sharp inequalities for the Maclaurin coefficients of an entire function from the Laguerre-Pólya class. They are obtained by a new technique involving the so-called very hyperbolic polynomials. The results may be considered as extensions of the classical Turan inequalities.001A02E03Analyse mathématique; Polynôme; Fonction entière; 30DxxMathematical analysis; Polynomial; Entire functionAnálisis matemático; Polinomio; Función enteraINIST-2980.35400019280354001011-0147302 001666 Assessing soil particle-size distribution on experimental plots with similar texture under different management systems using multifractal parametersJ. Paz-FerreiroFacultad de Ciencias, Universidade da Coruña15071, CoruñaESP1 aut.2 aut.E. Vidal VazquezFacultad de Ciencias, Universidade da Coruña15071, CoruñaESP1 aut.2 aut.J. G. V. MirandaInstituto de Física, Universidade Federal da Bahia, Campus de OndinaSalvador, BahiaBRA3 aut.11-01476172010PASCAL 11-0147617 INISTPascal:11-01476170012330016-7061Geoderma : (Amst.)Geoderma : (Amsterdam)Cropping systemDiffractionExperimental studyFieldField experimentField studyMultifractal systemParticle size distributionPhysical propertiesPlotPlowingProperty of soilSoil tillageSoilsSolid particleSpainStatistical analysisTexturelaser methodsParticule solideSolDistribution dimension particuleParcelleTextureEtude expérimentaleSystème multifractalAnalyse statistiquePropriété physiqueCaractéristique solMéthode laserDiffractionChampEtude sur terrainEssai en champLabourTravail solSystème cultureProvince de La CorogneEspagne
Soil particle-size distribution (PSD) is a fundamental soil physical attribute with dominant influence on many other soil properties. Laser diffraction combined with multifractal analyses have proven to be useful to obtain precise information from PSDs. The aim of this work was to assess similitude or difference of PSDs sampled on plots of an experimental field and belonging to the same textural class using multifractal parameters. The field experiment consisted of two tillage treatments and two cropping systems. It was conducted following a randomized complete split-block design with four replications on a Humic Dystrudept. Tillage treatments were conventional tillage (CT) and no tillage (NT) while crop rotations were ryegrass-sorghum (RS) and ryegrass-corn (RC). Particle-size distribution analysis by the sieve-pipette and by laser diffraction corroborate that all the samples were assigned to the same textural class. Singularity spectra f(α) and Rényi spectra, Dq, showed that multifractal distribution was a suitable model for PSDs obtained by laser diffraction. However, in the range of moments - 10<q<10, the r2 values for the linear fits leading to a Rényi spectrum, Dq, were higher than those for the singularity spectrum, suggesting the former was better defined than the latter. No significant differences in multifractal parameters were found between plots with contrasted crop rotation, RS and RC. In contrast, Hölder exponent of order zero (α0) and several parameters derived from the left branch of both, the f(α) and the Dq spectra, were significantly different between CT and NT treatments. No effects of mixing by cultivation were detected in our work, so that differences in PSDs between no-tilled and conventionally-tilled plots were simply attributed to patchiness and variation on the experimental field. Multifractal analysis of PSDs measured by laser diffraction provides further insight in verifying patterns of between plot soil texture variations (i.e. randomness or trends) in completely randomized block designs.
0016-7061GEDMABGeoderma : (Amst.)1601Assessing soil particle-size distribution on experimental plots with similar texture under different management systems using multifractal parametersComplexity and Nonlinearity in SoilsPAZ-FERREIRO (J.)VAZQUEZ (E. Vidal)MIRANDA (J. G. V.)TARQUIS (A. M.)ed.BIRD (N. R. A.)ed.PERRIER (E. M. A.)ed.CRAWFORD (J. W.)ed.Facultad de Ciencias, Universidade da Coruña15071, CoruñaESP1 aut.2 aut.Instituto de Física, Universidade Federal da Bahia, Campus de OndinaSalvador, BahiaBRA3 aut.Judith and David Coffey Chair, Faculty of Agriculture Food and Natural Resources, University of SydneySydney 2006AUS4 aut.Departamento de Matemática Aplicada, Universidad Politécnica de Madrid28040 MadridESP1 aut.Department of Soil Science, Rothamsted ResearchHarpenden, Herts, AL5 2JQGBR2 aut.Unité de Recherches GEODES UR079, Centre IRD Ile de France93143 BondyFRA3 aut.47-562010ENGINIST36073540001943399500600000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0147617PAGeoderma : (Amsterdam)NLDSoil particle-size distribution (PSD) is a fundamental soil physical attribute with dominant influence on many other soil properties. Laser diffraction combined with multifractal analyses have proven to be useful to obtain precise information from PSDs. The aim of this work was to assess similitude or difference of PSDs sampled on plots of an experimental field and belonging to the same textural class using multifractal parameters. The field experiment consisted of two tillage treatments and two cropping systems. It was conducted following a randomized complete split-block design with four replications on a Humic Dystrudept. Tillage treatments were conventional tillage (CT) and no tillage (NT) while crop rotations were ryegrass-sorghum (RS) and ryegrass-corn (RC). Particle-size distribution analysis by the sieve-pipette and by laser diffraction corroborate that all the samples were assigned to the same textural class. Singularity spectra f(α) and Rényi spectra, Dq, showed that multifractal distribution was a suitable model for PSDs obtained by laser diffraction. However, in the range of moments - 10<q<10, the r2 values for the linear fits leading to a Rényi spectrum, Dq, were higher than those for the singularity spectrum, suggesting the former was better defined than the latter. No significant differences in multifractal parameters were found between plots with contrasted crop rotation, RS and RC. In contrast, Hölder exponent of order zero (α0) and several parameters derived from the left branch of both, the f(α) and the Dq spectra, were significantly different between CT and NT treatments. No effects of mixing by cultivation were detected in our work, so that differences in PSDs between no-tilled and conventionally-tilled plots were simply attributed to patchiness and variation on the experimental field. Multifractal analysis of PSDs measured by laser diffraction provides further insight in verifying patterns of between plot soil texture variations (i.e. randomness or trends) in completely randomized block designs.002A32C04B2001E01P03001E01B03226C03220B03Particule solide01Solid particle01Partícula sólida01SolNT02SoilsNT02SueloNT02Distribution dimension particule03Particle size distribution03Distribución dimensión partícula03Parcelle04Plot04Parcela04Texture05Texture05Textura05Etude expérimentale06Experimental study06Estudio experimental06Système multifractal07Multifractal system07Sistema multifractal07Analyse statistique08Statistical analysis08Análisis estadístico08Propriété physique09Physical properties09Propiedad física09Caractéristique sol10Property of soil10Característica suelo10Méthode laser11laser methods11Laser11Diffraction13Diffraction13Difracción13Champ18Field18Campo18Etude sur terrain19Field study19Estudio en campo19Essai en champ20Field experiment20Ensayo en campo20Labour21Plowing21Aradura21Travail sol22Soil tillage22Labranza22Système culture24Cropping system24Sistema cultural24Province de La CorogneINC52EspagneNG61SpainNG61EspañaNG61EuropeNGEuropeNGEuropaNG094PASCAL 11-0147617 INISTAssessing soil particle-size distribution on experimental plots with similar texture under different management systems using multifractal parametersPAZ-FERREIRO (J.); VAZQUEZ (E. Vidal); MIRANDA (J. G. V.); TARQUIS (A. M.); BIRD (N. R. A.); PERRIER (E. M. A.); CRAWFORD (J. W.)Facultad de Ciencias, Universidade da Coruña/15071, Coruña/Espagne (1 aut., 2 aut.); Instituto de Física, Universidade Federal da Bahia, Campus de Ondina/Salvador, Bahia/Brésil (3 aut.); Judith and David Coffey Chair, Faculty of Agriculture Food and Natural Resources, University of Sydney/Sydney 2006/Australie (4 aut.); Departamento de Matemática Aplicada, Universidad Politécnica de Madrid/28040 Madrid/Espagne (1 aut.); Department of Soil Science, Rothamsted Research/Harpenden, Herts, AL5 2JQ/Royaume-Uni (2 aut.); Unité de Recherches GEODES UR079, Centre IRD Ile de France/93143 Bondy/France (3 aut.)
Publication en série; Niveau analytique
Geoderma : (Amsterdam); ISSN 0016-7061; Coden GEDMAB; Pays-Bas; Da. 2010; Vol. 160; No. 1; Pp. 47-56; Bibl. 3/4 p.AnglaisSoil particle-size distribution (PSD) is a fundamental soil physical attribute with dominant influence on many other soil properties. Laser diffraction combined with multifractal analyses have proven to be useful to obtain precise information from PSDs. The aim of this work was to assess similitude or difference of PSDs sampled on plots of an experimental field and belonging to the same textural class using multifractal parameters. The field experiment consisted of two tillage treatments and two cropping systems. It was conducted following a randomized complete split-block design with four replications on a Humic Dystrudept. Tillage treatments were conventional tillage (CT) and no tillage (NT) while crop rotations were ryegrass-sorghum (RS) and ryegrass-corn (RC). Particle-size distribution analysis by the sieve-pipette and by laser diffraction corroborate that all the samples were assigned to the same textural class. Singularity spectra f(α) and Rényi spectra, Dq, showed that multifractal distribution was a suitable model for PSDs obtained by laser diffraction. However, in the range of moments - 10<q<10, the r2 values for the linear fits leading to a Rényi spectrum, Dq, were higher than those for the singularity spectrum, suggesting the former was better defined than the latter. No significant differences in multifractal parameters were found between plots with contrasted crop rotation, RS and RC. In contrast, Hölder exponent of order zero (α0) and several parameters derived from the left branch of both, the f(α) and the Dq spectra, were significantly different between CT and NT treatments. No effects of mixing by cultivation were detected in our work, so that differences in PSDs between no-tilled and conventionally-tilled plots were simply attributed to patchiness and variation on the experimental field. Multifractal analysis of PSDs measured by laser diffraction provides further insight in verifying patterns of between plot soil texture variations (i.e. randomness or trends) in completely randomized block designs.002A32C04B2; 001E01P03; 001E01B03; 226C03; 220B03Particule solide; Sol; Distribution dimension particule; Parcelle; Texture; Etude expérimentale; Système multifractal; Analyse statistique; Propriété physique; Caractéristique sol; Méthode laser; Diffraction; Champ; Etude sur terrain; Essai en champ; Labour; Travail sol; Système culture; Province de La Corogne; EspagneEuropeSolid particle; Soils; Particle size distribution; Plot; Texture; Experimental study; Multifractal system; Statistical analysis; Physical properties; Property of soil; laser methods; Diffraction; Field; Field study; Field experiment; Plowing; Soil tillage; Cropping system; SpainEuropePartícula sólida; Suelo; Distribución dimensión partícula; Parcela; Textura; Estudio experimental; Sistema multifractal; Análisis estadístico; Propiedad física; Característica suelo; Laser; Difracción; Campo; Estudio en campo; Ensayo en campo; Aradura; Labranza; Sistema cultural; EspañaINIST-3607.35400019433995006011-0147617 001667 Inactivation of formyltransferase (wbkC) gene generates a Brucella abortus rough strain that is attenuated in macrophages and in miceThais Lourdes Santos LacerdaDepartment of Biochemistry and Immunology, Federal University of Minas GeraisBelo HorizonteBRA1 aut.3 aut.5 aut.6 aut.7 aut.12 aut.Patricia Gomes CardosoDepartment of Biology, Federal University of LavrasLavrasBRA2 aut.Leonardo Augusto De AlmeidaDepartment of Biochemistry and Immunology, Federal University of Minas GeraisBelo HorizonteBRA1 aut.3 aut.5 aut.6 aut.7 aut.12 aut.Ilana Lopes Baratella Da Cunha CamargoDepartment of Physics and Informatic, Physics Institute of São Carlos, University of São PauloSão CarlosBRA4 aut.Daniela Almeida Freitas AfonsoDepartment of Biochemistry and Immunology, Federal University of Minas GeraisBelo HorizonteBRA1 aut.3 aut.5 aut.6 aut.7 aut.12 aut.Cyntia Cardoso TrantDepartment of Biochemistry and Immunology, Federal University of Minas GeraisBelo HorizonteBRA1 aut.3 aut.5 aut.6 aut.7 aut.12 aut.Gilson Costa MacedoDepartment of Biochemistry and Immunology, Federal University of Minas GeraisBelo HorizonteBRA1 aut.3 aut.5 aut.6 aut.7 aut.12 aut.Eleonora CamposInstituto de Biotecnologia, INTA-CastelarCastelar, Buenos AiresARG8 aut.9 aut.Silvio L. CraveroInstituto de Biotecnologia, INTA-CastelarCastelar, Buenos AiresARG8 aut.9 aut.Suzana P. SalcedoCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Faculté de Sciences de LuminyMarseilleFRA10 aut.11 aut.INSERM, U631MarseilleFRA10 aut.11 aut.CNRS, UMR6102MarseilleFRA10 aut.11 aut.Jean-Pierre GorvelCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Faculté de Sciences de LuminyMarseilleFRA10 aut.11 aut.INSERM, U631MarseilleFRA10 aut.11 aut.CNRS, UMR6102MarseilleFRA10 aut.11 aut.Sérgio Costa OliveiraDepartment of Biochemistry and Immunology, Federal University of Minas GeraisBelo HorizonteBRA1 aut.3 aut.5 aut.6 aut.7 aut.12 aut.11-01494392010PASCAL 11-0149439 INISTPascal:11-01494390012320264-410XVaccineVaccineAttenuated strainBrucella abortusFormyltransferaseGeneMacrophageMouseRough formVaccineBrucella abortusSourisFormyltransferaseGèneForme rugueuseSouche atténuéeMacrophageVaccin
Rough mutants of Brucella abortus were generated by disruption of wbkC gene which encodes the formyltransferase enzyme involved in LPS biosynthesis. In bone marrow-derived macrophages the B. abortus ΔwbkC mutants were attenuated, could not reach a replicative niche and induced higher levels of IL-12 and TNF-α when compared to parental smooth strains. Additionally, mutants exhibited attenuation in vivo in C57BL/6 and interferon regulatory factor-1 knockout mice. ΔwbkC mutant strains induced lower protective immunity in C56BL/6 than smooth vaccine S19 but similar to rough vaccine RB51. Finally, we demonstrated that Brucella wbkC is critical for LPS biosynthesis and full bacterial virulence.
0264-410XVACCDEVaccine2834Inactivation of formyltransferase (wbkC) gene generates a Brucella abortus rough strain that is attenuated in macrophages and in miceSANTOS LACERDA (Thais Lourdes)CARDOSO (Patricia Gomes)DE ALMEIDA (Leonardo Augusto)DA CUNHA CAMARGO (Ilana Lopes Baratella)FREITAS AFONSO (Daniela Almeida)TRANT (Cyntia Cardoso)COSTA MACEDO (Gilson)CAMPOS (Eleonora)CRAVERO (Silvio L.)SALCEDO (Suzana P.)GORVEL (Jean-Pierre)OLIVEIRA (Sérgio Costa)Department of Biochemistry and Immunology, Federal University of Minas GeraisBelo HorizonteBRA1 aut.3 aut.5 aut.6 aut.7 aut.12 aut.Department of Biology, Federal University of LavrasLavrasBRA2 aut.Department of Physics and Informatic, Physics Institute of São Carlos, University of São PauloSão CarlosBRA4 aut.Instituto de Biotecnologia, INTA-CastelarCastelar, Buenos AiresARG8 aut.9 aut.Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Faculté de Sciences de LuminyMarseilleFRA10 aut.11 aut.INSERM, U631MarseilleFRA10 aut.11 aut.CNRS, UMR6102MarseilleFRA10 aut.11 aut.5627-56342010ENGINIST202893540001917835001600000© 2011 INIST-CNRS. All rights reserved.27 ref.11-0149439PAVaccineGBRRough mutants of Brucella abortus were generated by disruption of wbkC gene which encodes the formyltransferase enzyme involved in LPS biosynthesis. In bone marrow-derived macrophages the B. abortus ΔwbkC mutants were attenuated, could not reach a replicative niche and induced higher levels of IL-12 and TNF-α when compared to parental smooth strains. Additionally, mutants exhibited attenuation in vivo in C57BL/6 and interferon regulatory factor-1 knockout mice. ΔwbkC mutant strains induced lower protective immunity in C56BL/6 than smooth vaccine S19 but similar to rough vaccine RB51. Finally, we demonstrated that Brucella wbkC is critical for LPS biosynthesis and full bacterial virulence.002A05F04002A05B15Brucella abortusNS01Brucella abortusNS01Brucella abortusNS01Souris02Mouse02Ratón02FormyltransferaseFE05FormyltransferaseFE05FormyltransferaseFE05Gène06Gene06Gen06Forme rugueuse07Rough form07Forma rugosa07Souche atténuée08Attenuated strain08Cepa atenuada08Macrophage09Macrophage09Macrófago09Vaccin10Vaccine10Vacuna10BrucellaceaeNSBrucellaceaeNSBrucellaceaeNSBactérieBacteriaBacteriaRodentiaNSRodentiaNSRodentiaNSMammaliaNSMammaliaNSMammaliaNSVertebrataNSVertebrataNSVertebrataNSTransferasesFETransferasesFETransferasesFEEnzymeFEEnzymeFEEnzimaFE101OTOOTOPASCAL 11-0149439 INISTInactivation of formyltransferase (wbkC) gene generates a Brucella abortus rough strain that is attenuated in macrophages and in miceSANTOS LACERDA (Thais Lourdes); CARDOSO (Patricia Gomes); DE ALMEIDA (Leonardo Augusto); DA CUNHA CAMARGO (Ilana Lopes Baratella); FREITAS AFONSO (Daniela Almeida); TRANT (Cyntia Cardoso); COSTA MACEDO (Gilson); CAMPOS (Eleonora); CRAVERO (Silvio L.); SALCEDO (Suzana P.); GORVEL (Jean-Pierre); OLIVEIRA (Sérgio Costa)Department of Biochemistry and Immunology, Federal University of Minas Gerais/Belo Horizonte/Brésil (1 aut., 3 aut., 5 aut., 6 aut., 7 aut., 12 aut.); Department of Biology, Federal University of Lavras/Lavras/Brésil (2 aut.); Department of Physics and Informatic, Physics Institute of São Carlos, University of São Paulo/São Carlos/Brésil (4 aut.); Instituto de Biotecnologia, INTA-Castelar/Castelar, Buenos Aires/Argentine (8 aut., 9 aut.); Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Faculté de Sciences de Luminy/Marseille/France (10 aut., 11 aut.); INSERM, U631/Marseille/France (10 aut., 11 aut.); CNRS, UMR6102/Marseille/France (10 aut., 11 aut.)
Publication en série; Niveau analytique
Vaccine; ISSN 0264-410X; Coden VACCDE; Royaume-Uni; Da. 2010; Vol. 28; No. 34; Pp. 5627-5634; Bibl. 27 ref.AnglaisRough mutants of Brucella abortus were generated by disruption of wbkC gene which encodes the formyltransferase enzyme involved in LPS biosynthesis. In bone marrow-derived macrophages the B. abortus ΔwbkC mutants were attenuated, could not reach a replicative niche and induced higher levels of IL-12 and TNF-α when compared to parental smooth strains. Additionally, mutants exhibited attenuation in vivo in C57BL/6 and interferon regulatory factor-1 knockout mice. ΔwbkC mutant strains induced lower protective immunity in C56BL/6 than smooth vaccine S19 but similar to rough vaccine RB51. Finally, we demonstrated that Brucella wbkC is critical for LPS biosynthesis and full bacterial virulence.002A05F04; 002A05B15Brucella abortus; Souris; Formyltransferase; Gène; Forme rugueuse; Souche atténuée; Macrophage; VaccinBrucellaceae; Bactérie; Rodentia; Mammalia; Vertebrata; Transferases; EnzymeBrucella abortus; Mouse; Formyltransferase; Gene; Rough form; Attenuated strain; Macrophage; VaccineBrucellaceae; Bacteria; Rodentia; Mammalia; Vertebrata; Transferases; EnzymeBrucella abortus; Ratón; Formyltransferase; Gen; Forma rugosa; Cepa atenuada; Macrófago; VacunaINIST-20289.35400019178350016011-0149439 001668 The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organization: Pregnancy and PediatricsUma MahadevanDepartment of Gastroenterology, UCSF Center for Colitis and Crohn's DiseaseSan Francisco, CaliforniaUSA1 aut.Salvatore CucchiaraDepartment of Pediatrics, University Hospital Umberto I, Sapienza University of RomeRomeITA2 aut.Jeffrey S. HyamsDepartment of Pediatric Gastroenterology, Connecticut Childrens Medical CenterHartford, ConnecticutUSA3 aut.Flavio SteinwurzDepartment of Gastroenterology, Hospital Israelita Albert EinsteinSão PauloBRA4 aut.F. NutiPediatric Gastroenterology and Liver Unit, Sapienza UniversityRomeITA5 aut.Simon P. L. TravisDepartment of Gastroenterology, John Radcliffe HospitalOxfordGBR6 aut.William J. SandbornMayo ClinicRochester, MinnesotaUSA7 aut.Jean-Frederio ColombelDepartment of Hepato-Gastroenterology, Hospital HuriezLilleFRA8 aut.11-01509362011PASCAL 11-0150936 INISTPascal:11-01509360012310002-9270Am. j. gastroenterol.The American journal of gastroenterologyBiotherapyChildColitisCongressCrohn diseaseEuropeanGastroenterologyPediatricsPregnancyUlcerative colitisWorldRectocolite ulcérohémorragiqueEntérite de CrohnBiothérapieMondeCongrèsGastroentérologieEuropéenColiteGestationEnfantPédiatrie
Women with inflammatory bowel disease (IBD) have similar rates of fertility to the general population, but have an increased rate of adverse pregnancy outcomes compared with the general population, which may be worsened by disease activity. Infertility is increased in those undergoing ileal pouch-anal anastomosis. Anti-tumor necrosis factor therapy in pregnancy is considered to be low risk and compatible with use during conception in men and women and during pregnancy in at least the first two trimesters. Infliximab (IFX) and certolizumab pegol are also compatible with breastfeeding, but safety data for adalimumab (ADA) are awaited. The safety of natalizumab during pregnancy is unknown. For children with Crohn's disease (CD), IFX is effective at inducing and maintaining remission. Episodic therapy is not as effective as scheduled infusions. Disease duration in children does not appear to affect the efficacy of IFX. IFX promotes growth in prepubertal and early pubertal Crohn's patients. It is also effective for the treatment of extraintestinal manifestations. ADA is effective for children with active CD and for maintaining remission, even if they have lost response to IFX, although there are fewer data. Vaccination of infants exposed to biological therapy in utero should be given at standard schedules during the first 6 months of life, except for live-virus vaccines such as rotavirus. Inactivated vaccines may be safely administered to children with IBD, even when immunocompromised.
0002-9270Am. j. gastroenterol.1062The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organization: Pregnancy and PediatricsMAHADEVAN (Uma)CUCCHIARA (Salvatore)HYAMS (Jeffrey S.)STEINWURZ (Flavio)NUTI (F.)TRAVIS (Simon P. L.)SANDBORN (William J.)COLOMBEL (Jean-Frederio)Department of Gastroenterology, UCSF Center for Colitis and Crohn's DiseaseSan Francisco, CaliforniaUSA1 aut.Department of Pediatrics, University Hospital Umberto I, Sapienza University of RomeRomeITA2 aut.Department of Pediatric Gastroenterology, Connecticut Childrens Medical CenterHartford, ConnecticutUSA3 aut.Department of Gastroenterology, Hospital Israelita Albert EinsteinSão PauloBRA4 aut.Pediatric Gastroenterology and Liver Unit, Sapienza UniversityRomeITA5 aut.Department of Gastroenterology, John Radcliffe HospitalOxfordGBR6 aut.Mayo ClinicRochester, MinnesotaUSA7 aut.Department of Hepato-Gastroenterology, Hospital HuriezLilleFRA8 aut.214-2232011ENGINIST110623540001944085900600000© 2011 INIST-CNRS. All rights reserved.104 ref.11-0150936PAThe American journal of gastroenterologyGBRWomen with inflammatory bowel disease (IBD) have similar rates of fertility to the general population, but have an increased rate of adverse pregnancy outcomes compared with the general population, which may be worsened by disease activity. Infertility is increased in those undergoing ileal pouch-anal anastomosis. Anti-tumor necrosis factor therapy in pregnancy is considered to be low risk and compatible with use during conception in men and women and during pregnancy in at least the first two trimesters. Infliximab (IFX) and certolizumab pegol are also compatible with breastfeeding, but safety data for adalimumab (ADA) are awaited. The safety of natalizumab during pregnancy is unknown. For children with Crohn's disease (CD), IFX is effective at inducing and maintaining remission. Episodic therapy is not as effective as scheduled infusions. Disease duration in children does not appear to affect the efficacy of IFX. IFX promotes growth in prepubertal and early pubertal Crohn's patients. It is also effective for the treatment of extraintestinal manifestations. ADA is effective for children with active CD and for maintaining remission, even if they have lost response to IFX, although there are fewer data. Vaccination of infants exposed to biological therapy in utero should be given at standard schedules during the first 6 months of life, except for live-virus vaccines such as rotavirus. Inactivated vaccines may be safely administered to children with IBD, even when immunocompromised.002B13B03Rectocolite ulcérohémorragique01Ulcerative colitis01Rectocolitis ulcerohemorrágica01Entérite de Crohn02Crohn disease02Enteritis Crohn02Biothérapie04Biotherapy04Bioterapia04MondeNG07WorldNG07MundoNG07Congrès08Congress08Congreso08Gastroentérologie09Gastroenterology09Gastroenterología09Européen13European13Europeo13Colite14Colitis14Colitis14Gestation15Pregnancy15Gestación15Enfant16Child16Niño16Pédiatrie17Pediatrics17Pediatría17HommeHumanHombrePathologie de l'appareil digestif37Digestive diseases37Aparato digestivo patología37Pathologie de l'intestin38Intestinal disease38Intestino patología38Maladie inflammatoire39Inflammatory disease39Enfermedad inflamatoria39101OTOOTOPASCAL 11-0150936 INISTThe London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organization: Pregnancy and PediatricsMAHADEVAN (Uma); CUCCHIARA (Salvatore); HYAMS (Jeffrey S.); STEINWURZ (Flavio); NUTI (F.); TRAVIS (Simon P. L.); SANDBORN (William J.); COLOMBEL (Jean-Frederio)Department of Gastroenterology, UCSF Center for Colitis and Crohn's Disease/San Francisco, California/Etats-Unis (1 aut.); Department of Pediatrics, University Hospital Umberto I, Sapienza University of Rome/Rome/Italie (2 aut.); Department of Pediatric Gastroenterology, Connecticut Childrens Medical Center/Hartford, Connecticut/Etats-Unis (3 aut.); Department of Gastroenterology, Hospital Israelita Albert Einstein/São Paulo/Brésil (4 aut.); Pediatric Gastroenterology and Liver Unit, Sapienza University/Rome/Italie (5 aut.); Department of Gastroenterology, John Radcliffe Hospital/Oxford/Royaume-Uni (6 aut.); Mayo Clinic/Rochester, Minnesota/Etats-Unis (7 aut.); Department of Hepato-Gastroenterology, Hospital Huriez/Lille/France (8 aut.)
Publication en série; Niveau analytique
The American journal of gastroenterology; ISSN 0002-9270; Royaume-Uni; Da. 2011; Vol. 106; No. 2; Pp. 214-223; Bibl. 104 ref.AnglaisWomen with inflammatory bowel disease (IBD) have similar rates of fertility to the general population, but have an increased rate of adverse pregnancy outcomes compared with the general population, which may be worsened by disease activity. Infertility is increased in those undergoing ileal pouch-anal anastomosis. Anti-tumor necrosis factor therapy in pregnancy is considered to be low risk and compatible with use during conception in men and women and during pregnancy in at least the first two trimesters. Infliximab (IFX) and certolizumab pegol are also compatible with breastfeeding, but safety data for adalimumab (ADA) are awaited. The safety of natalizumab during pregnancy is unknown. For children with Crohn's disease (CD), IFX is effective at inducing and maintaining remission. Episodic therapy is not as effective as scheduled infusions. Disease duration in children does not appear to affect the efficacy of IFX. IFX promotes growth in prepubertal and early pubertal Crohn's patients. It is also effective for the treatment of extraintestinal manifestations. ADA is effective for children with active CD and for maintaining remission, even if they have lost response to IFX, although there are fewer data. Vaccination of infants exposed to biological therapy in utero should be given at standard schedules during the first 6 months of life, except for live-virus vaccines such as rotavirus. Inactivated vaccines may be safely administered to children with IBD, even when immunocompromised.002B13B03Rectocolite ulcérohémorragique; Entérite de Crohn; Biothérapie; Monde; Congrès; Gastroentérologie; Européen; Colite; Gestation; Enfant; PédiatrieHomme; Pathologie de l'appareil digestif; Pathologie de l'intestin; Maladie inflammatoireUlcerative colitis; Crohn disease; Biotherapy; World; Congress; Gastroenterology; European; Colitis; Pregnancy; Child; PediatricsHuman; Digestive diseases; Intestinal disease; Inflammatory diseaseRectocolitis ulcerohemorrágica; Enteritis Crohn; Bioterapia; Mundo; Congreso; Gastroenterología; Europeo; Colitis; Gestación; Niño; PediatríaINIST-11062.35400019440859006011-0150936 001669 Whole Earth Telescope observations of the subdwarf B star KPD 1930<sub>+</sub>2752: a rich, short-period pulsator in a close binaryM. D. ReedDepartment of Physics, Astronomy, and Materials Science, Missouri State UniversitySpringfield, MO 65897USA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.S. L. HarmsDepartment of Physics, Astronomy, and Materials Science, Missouri State UniversitySpringfield, MO 65897USA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.S. PoindexterDepartment of Physics, Astronomy, and Materials Science, Missouri State UniversitySpringfield, MO 65897USA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.Department of Astronomy, The Ohio State University, 140 W. 18th Ave.Columbus, OH 43210USA3 aut.A.-Y. ZhouDepartment of Physics, Astronomy, and Materials Science, Missouri State UniversitySpringfield, MO 65897USA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.National Astronomical Observatories, Chinese Academy of ScienciesBeijing 100012CHN4 aut.J. R. EggenDepartment of Physics, Astronomy, and Materials Science, Missouri State UniversitySpringfield, MO 65897USA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.M. A. MorrisDepartment of Physics, Astronomy, and Materials Science, Missouri State UniversitySpringfield, MO 65897USA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.School of Earth and Space Exploration, Arizona State University, PO Box 871404Tempe, AZ 85287-1404USA6 aut.A. C. QuintDepartment of Physics, Astronomy, and Materials Science, Missouri State UniversitySpringfield, MO 65897USA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.S. McdanielDepartment of Physics, Astronomy, and Materials Science, Missouri State UniversitySpringfield, MO 65897USA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.A. BaranMt Suhora Observatory of the Pedagogical University, ul. Podchoraą zych 230-084 KracowPOL9 aut.15 aut.48 aut.49 aut.N. DolezLaboratoire d'Astrophysique de Toulouse-Tarbes, Université de Toulouse, CNRS, 14 Av. Ed. Belin31400 ToulouseFRA10 aut.57 aut.S. D. KawalerDepartment of Physics and Astronomy Iowa State UniversityAmes, IA 50011USA11 aut.14 aut.23 aut.D. W. KurtzCentre for Astrophysics, University of Central LancashirePreston PR1 2HEGBR12 aut.P. MoskalikNicolaus Copernicus Astronomical Center, ul. Bartycka 1800-716 WarsawPOL13 aut.R. RiddleDepartment of Physics and Astronomy Iowa State UniversityAmes, IA 50011USA11 aut.14 aut.23 aut.California Institute of Technology, 1200 E. California Blvd MC 11-17Pasadena, CA 91125USA14 aut.S. ZolaMt Suhora Observatory of the Pedagogical University, ul. Podchoraą zych 230-084 KracowPOL9 aut.15 aut.48 aut.49 aut.Astronomical Observatory, Jagiellonian University, ul. Orla 17130-244 CracowPOL15 aut.R. H. StensenIsaac Newton Group of Telescopes, 37800 Santa Cruz de La PalmaESP16 aut.Instituut voor Sterrenkunde, Katholieke Universiteit Leuven, Celestijnenlaan 200 D3001 LeuvenBEL16 aut.23 aut.J.-E. SolheimInstitutt for Teoretisk Astrofysikk, Universitetet i Oslo0212 Blindern-OsloNOR17 aut.S. O. KeplerInstituto de Fisica, UFRGS, CP 1505191501-970 Porto Alegre, RSBRA18 aut.A. F. M. CostaUniversidade do Estado de Santa Catarina, CAVCP 88520-000 Lages, SCBRA19 aut.J. L. ProvencalMount Cuba Observatory and University of DelawareNewark, DE 19716USA20 aut.F. MullallyMcDonald Observatory, and Department of Astronomy University of TexasAustin, TX 78712USA21 aut.22 aut.D. W. WingetMcDonald Observatory, and Department of Astronomy University of TexasAustin, TX 78712USA21 aut.22 aut.M. VuckovicDepartment of Physics and Astronomy Iowa State UniversityAmes, IA 50011USA11 aut.14 aut.23 aut.Instituut voor Sterrenkunde, Katholieke Universiteit Leuven, Celestijnenlaan 200 D3001 LeuvenBEL16 aut.23 aut.R. CroweDepartment of Physics and Astronomy, University of Hawaii-Hilo, 200 West Kawili StreetHilo, HI 96720-4091USA24 aut.25 aut.26 aut.27 aut.28 aut.29 aut.30 aut.31 aut.D. TerryDepartment of Physics and Astronomy, University of Hawaii-Hilo, 200 West Kawili StreetHilo, HI 96720-4091USA24 aut.25 aut.26 aut.27 aut.28 aut.29 aut.30 aut.31 aut.R. AvilaDepartment of Physics and Astronomy, University of Hawaii-Hilo, 200 West Kawili StreetHilo, HI 96720-4091USA24 aut.25 aut.26 aut.27 aut.28 aut.29 aut.30 aut.31 aut.Department of Astronomy, New Mexico State University, Box 30001Las Cruces, NM 88003USA26 aut.B. BerkeyDepartment of Physics and Astronomy, University of Hawaii-Hilo, 200 West Kawili StreetHilo, HI 96720-4091USA24 aut.25 aut.26 aut.27 aut.28 aut.29 aut.30 aut.31 aut.W.M. Keck ObservatoryKamuela, HI 96743USA27 aut.S. StewartDepartment of Physics and Astronomy, University of Hawaii-Hilo, 200 West Kawili StreetHilo, HI 96720-4091USA24 aut.25 aut.26 aut.27 aut.28 aut.29 aut.30 aut.31 aut.J. BodnarikDepartment of Physics and Astronomy, University of Hawaii-Hilo, 200 West Kawili StreetHilo, HI 96720-4091USA24 aut.25 aut.26 aut.27 aut.28 aut.29 aut.30 aut.31 aut.Gemini Observatory, 670 North A'ohoku PlaceHilo, HI 96720USA29 aut.D. BoltonDepartment of Physics and Astronomy, University of Hawaii-Hilo, 200 West Kawili StreetHilo, HI 96720-4091USA24 aut.25 aut.26 aut.27 aut.28 aut.29 aut.30 aut.31 aut.P.-M. BinderDepartment of Physics and Astronomy, University of Hawaii-Hilo, 200 West Kawili StreetHilo, HI 96720-4091USA24 aut.25 aut.26 aut.27 aut.28 aut.29 aut.30 aut.31 aut.K. SekiguchiSubaru Observatory, National Astronomical Observatory of Japan, 650 North A'ohoku PlaceHilo, HI 96720USA32 aut.D. J. SullivanSchool of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600WellingtonNZL33 aut.S.-L. KimKorea Astronomy ObservatoryDaejeon 305-348KOR34 aut.W.-P. ChenC.-W. ChenH.-C. LinX.-J. JianH. WuJ.-P. GouZ. LiuE. LeibowitzY. LipkinC. AkanO. CakirliR. JanulisR. PretoriusW. OglozaMt Suhora Observatory of the Pedagogical University, ul. Podchoraą zych 230-084 KracowPOL9 aut.15 aut.48 aut.49 aut.G. StachowskiMt Suhora Observatory of the Pedagogical University, ul. Podchoraą zych 230-084 KracowPOL9 aut.15 aut.48 aut.49 aut.M. PaparoR. SzaboZ. CsubryD. ZsuffaR. SilvottiS. MarinoniI. BruniG. VauclairLaboratoire d'Astrophysique de Toulouse-Tarbes, Université de Toulouse, CNRS, 14 Av. Ed. Belin31400 ToulouseFRA10 aut.57 aut.M. ChevretonJ. M. Matthews11-01513802011PASCAL 11-0151380 INISTPascal:11-01513800012300035-8711Mon. Not. R. Astron. Soc.Monthly Notices of the Royal Astronomical SocietyB starsClose binary starsMultipletsOscillation frequencyPhotometric observationSubdwarfVariabilityWhite dwarf starsSous naineEtoile BBinaire serréeNaine blancheObservation photométriqueFréquence oscillationMultipletVariabilité
KPD 1930+2752 is a short-period pulsating subdwarf B (sdB) star. It is also an ellipsoidal variable with a known binary period of 2.3 h. The companion is most likely a white dwarf and the total mass of the system is close to the Chandresekhar limit. In this paper, we report the results of Whole Earth Telescope (WET) photometric observations during 2003 and a smaller multisite campaign of 2002. From 355 h of WET data, we detect 68 pulsation frequencies and suggest an additional 13 frequencies within a crowded and complex temporal spectrum between 3065 and 6343 μHz (periods between 326 and 157 s). We examine pulsation properties including phase and amplitude stability in an attempt to understand the nature of the pulsation mechanism. We examine a stochastic mechanism by comparing amplitude variations with simulated stochastic data. We also use the binary nature of KPD 1930+2752 for identifying pulsation modes via multiplet structure and a tidally induced pulsation geometry. Our results indicate a complicated pulsation structure that includes short-period (≃16 h) amplitude variability, rotationally split modes, tidally induced modes and some pulsations which are geometrically limited on the sdB star.
0035-8711MNRAA4Mon. Not. R. Astron. Soc.4121Whole Earth Telescope observations of the subdwarf B star KPD 1930+2752: a rich, short-period pulsator in a close binaryREED (M. D.)HARMS (S. L.)POINDEXTER (S.)ZHOU (A.-Y.)EGGEN (J. R.)MORRIS (M. A.)QUINT (A. C.)MCDANIEL (S.)BARAN (A.)DOLEZ (N.)KAWALER (S. D.)KURTZ (D. W.)MOSKALIK (P.)RIDDLE (R.)ZOLA (S.)ØSTENSEN (R. H.)SOLHEIM (J.-E.)KEPLER (S. O.)COSTA (A. F. M.)PROVENCAL (J. L.)MULLALLY (F.)WINGET (D. W.)VUCKOVIC (M.)CROWE (R.)TERRY (D.)AVILA (R.)BERKEY (B.)STEWART (S.)BODNARIK (J.)BOLTON (D.)BINDER (P.-M.)SEKIGUCHI (K.)SULLIVAN (D. J.)KIM (S.-L.)CHEN (W.-P.)CHEN (C.-W.)LIN (H.-C.)JIAN (X.-J.)WU (H.)GOU (J.-P.)LIU (Z.)LEIBOWITZ (E.)LIPKIN (Y.)AKAN (C.)CAKIRLI (O.)JANULIS (R.)PRETORIUS (R.)OGLOZA (W.)STACHOWSKI (G.)PAPARO (M.)SZABO (R.)CSUBRY (Z.)ZSUFFA (D.)SILVOTTI (R.)MARINONI (S.)BRUNI (I.)VAUCLAIR (G.)CHEVRETON (M.)MATTHEWS (J. M.)Department of Physics, Astronomy, and Materials Science, Missouri State UniversitySpringfield, MO 65897USA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.Department of Astronomy, The Ohio State University, 140 W. 18th Ave.Columbus, OH 43210USA3 aut.National Astronomical Observatories, Chinese Academy of ScienciesBeijing 100012CHN4 aut.School of Earth and Space Exploration, Arizona State University, PO Box 871404Tempe, AZ 85287-1404USA6 aut.Mt Suhora Observatory of the Pedagogical University, ul. Podchoraą zych 230-084 KracowPOL9 aut.15 aut.48 aut.49 aut.Laboratoire d'Astrophysique de Toulouse-Tarbes, Université de Toulouse, CNRS, 14 Av. Ed. Belin31400 ToulouseFRA10 aut.57 aut.Department of Physics and Astronomy Iowa State UniversityAmes, IA 50011USA11 aut.14 aut.23 aut.Centre for Astrophysics, University of Central LancashirePreston PR1 2HEGBR12 aut.Nicolaus Copernicus Astronomical Center, ul. Bartycka 1800-716 WarsawPOL13 aut.California Institute of Technology, 1200 E. California Blvd MC 11-17Pasadena, CA 91125USA14 aut.Astronomical Observatory, Jagiellonian University, ul. Orla 17130-244 CracowPOL15 aut.Isaac Newton Group of Telescopes, 37800 Santa Cruz de La PalmaESP16 aut.Instituut voor Sterrenkunde, Katholieke Universiteit Leuven, Celestijnenlaan 200 D3001 LeuvenBEL16 aut.23 aut.Institutt for Teoretisk Astrofysikk, Universitetet i Oslo0212 Blindern-OsloNOR17 aut.Instituto de Fisica, UFRGS, CP 1505191501-970 Porto Alegre, RSBRA18 aut.Universidade do Estado de Santa Catarina, CAVCP 88520-000 Lages, SCBRA19 aut.Mount Cuba Observatory and University of DelawareNewark, DE 19716USA20 aut.McDonald Observatory, and Department of Astronomy University of TexasAustin, TX 78712USA21 aut.22 aut.Department of Physics and Astronomy, University of Hawaii-Hilo, 200 West Kawili StreetHilo, HI 96720-4091USA24 aut.25 aut.26 aut.27 aut.28 aut.29 aut.30 aut.31 aut.Department of Astronomy, New Mexico State University, Box 30001Las Cruces, NM 88003USA26 aut.W.M. Keck ObservatoryKamuela, HI 96743USA27 aut.Gemini Observatory, 670 North A'ohoku PlaceHilo, HI 96720USA29 aut.Subaru Observatory, National Astronomical Observatory of Japan, 650 North A'ohoku PlaceHilo, HI 96720USA32 aut.School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600WellingtonNZL33 aut.Korea Astronomy ObservatoryDaejeon 305-348KOR34 aut.371-3902011ENGINIST20673540001928006503100000© 2011 INIST-CNRS. All rights reserved.1/4 p.11-0151380PAMonthly Notices of the Royal Astronomical SocietyUSAKPD 1930+2752 is a short-period pulsating subdwarf B (sdB) star. It is also an ellipsoidal variable with a known binary period of 2.3 h. The companion is most likely a white dwarf and the total mass of the system is close to the Chandresekhar limit. In this paper, we report the results of Whole Earth Telescope (WET) photometric observations during 2003 and a smaller multisite campaign of 2002. From 355 h of WET data, we detect 68 pulsation frequencies and suggest an additional 13 frequencies within a crowded and complex temporal spectrum between 3065 and 6343 μHz (periods between 326 and 157 s). We examine pulsation properties including phase and amplitude stability in an attempt to understand the nature of the pulsation mechanism. We examine a stochastic mechanism by comparing amplitude variations with simulated stochastic data. We also use the binary nature of KPD 1930+2752 for identifying pulsation modes via multiplet structure and a tidally induced pulsation geometry. Our results indicate a complicated pulsation structure that includes short-period (≃16 h) amplitude variability, rotationally split modes, tidally induced modes and some pulsations which are geometrically limited on the sdB star.001E03Sous naine26Subdwarf26Subenana26Etoile B27B stars27Binaire serrée28Close binary stars28Naine blanche29White dwarf stars29Observation photométrique30Photometric observation30Observación fotométrica30Fréquence oscillation31Oscillation frequency31Frecuencia oscilación31Multiplet32Multiplets32Variabilité33Variability33Variabilidad33101OTOOTOPASCAL 11-0151380 INISTWhole Earth Telescope observations of the subdwarf B star KPD 1930+2752: a rich, short-period pulsator in a close binaryREED (M. D.); HARMS (S. L.); POINDEXTER (S.); ZHOU (A.-Y.); EGGEN (J. R.); MORRIS (M. A.); QUINT (A. C.); MCDANIEL (S.); BARAN (A.); DOLEZ (N.); KAWALER (S. D.); KURTZ (D. W.); MOSKALIK (P.); RIDDLE (R.); ZOLA (S.); ØSTENSEN (R. H.); SOLHEIM (J.-E.); KEPLER (S. O.); COSTA (A. F. M.); PROVENCAL (J. L.); MULLALLY (F.); WINGET (D. W.); VUCKOVIC (M.); CROWE (R.); TERRY (D.); AVILA (R.); BERKEY (B.); STEWART (S.); BODNARIK (J.); BOLTON (D.); BINDER (P.-M.); SEKIGUCHI (K.); SULLIVAN (D. J.); KIM (S.-L.); CHEN (W.-P.); CHEN (C.-W.); LIN (H.-C.); JIAN (X.-J.); WU (H.); GOU (J.-P.); LIU (Z.); LEIBOWITZ (E.); LIPKIN (Y.); AKAN (C.); CAKIRLI (O.); JANULIS (R.); PRETORIUS (R.); OGLOZA (W.); STACHOWSKI (G.); PAPARO (M.); SZABO (R.); CSUBRY (Z.); ZSUFFA (D.); SILVOTTI (R.); MARINONI (S.); BRUNI (I.); VAUCLAIR (G.); CHEVRETON (M.); MATTHEWS (J. M.)Department of Physics, Astronomy, and Materials Science, Missouri State University/Springfield, MO 65897/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Department of Astronomy, The Ohio State University, 140 W. 18th Ave./Columbus, OH 43210/Etats-Unis (3 aut.); National Astronomical Observatories, Chinese Academy of Sciencies/Beijing 100012/Chine (4 aut.); School of Earth and Space Exploration, Arizona State University, PO Box 871404/Tempe, AZ 85287-1404/Etats-Unis (6 aut.); Mt Suhora Observatory of the Pedagogical University, ul. Podchoraą zych 2/30-084 Kracow/Pologne (9 aut., 15 aut., 48 aut., 49 aut.); Laboratoire d'Astrophysique de Toulouse-Tarbes, Université de Toulouse, CNRS, 14 Av. Ed. Belin/31400 Toulouse/France (10 aut., 57 aut.); Department of Physics and Astronomy Iowa State University/Ames, IA 50011/Etats-Unis (11 aut., 14 aut., 23 aut.); Centre for Astrophysics, University of Central Lancashire/Preston PR1 2HE/Royaume-Uni (12 aut.); Nicolaus Copernicus Astronomical Center, ul. Bartycka 18/00-716 Warsaw/Pologne (13 aut.); California Institute of Technology, 1200 E. California Blvd MC 11-17/Pasadena, CA 91125/Etats-Unis (14 aut.); Astronomical Observatory, Jagiellonian University, ul. Orla 171/30-244 Cracow/Pologne (15 aut.); Isaac Newton Group of Telescopes, 37800 Santa Cruz de La Palma/Espagne (16 aut.); Instituut voor Sterrenkunde, Katholieke Universiteit Leuven, Celestijnenlaan 200 D/3001 Leuven/Belgique (16 aut., 23 aut.); Institutt for Teoretisk Astrofysikk, Universitetet i Oslo/0212 Blindern-Oslo/Norvège (17 aut.); Instituto de Fisica, UFRGS, CP 15051/91501-970 Porto Alegre, RS/Brésil (18 aut.); Universidade do Estado de Santa Catarina, CAV/CP 88520-000 Lages, SC/Brésil (19 aut.); Mount Cuba Observatory and University of Delaware/Newark, DE 19716/Etats-Unis (20 aut.); McDonald Observatory, and Department of Astronomy University of Texas/Austin, TX 78712/Etats-Unis (21 aut., 22 aut.); Department of Physics and Astronomy, University of Hawaii-Hilo, 200 West Kawili Street/Hilo, HI 96720-4091/Etats-Unis (24 aut., 25 aut., 26 aut., 27 aut., 28 aut., 29 aut., 30 aut., 31 aut.); Department of Astronomy, New Mexico State University, Box 30001/Las Cruces, NM 88003/Etats-Unis (26 aut.); W.M. Keck Observatory/Kamuela, HI 96743/Etats-Unis (27 aut.); Gemini Observatory, 670 North A'ohoku Place/Hilo, HI 96720/Etats-Unis (29 aut.); Subaru Observatory, National Astronomical Observatory of Japan, 650 North A'ohoku Place/Hilo, HI 96720/Etats-Unis (32 aut.); School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600/Wellington/Nouvelle-Zélande (33 aut.); Korea Astronomy Observatory/Daejeon 305-348/Corée, République de (34 aut.)
Publication en série; Niveau analytique
Monthly Notices of the Royal Astronomical Society; ISSN 0035-8711; Coden MNRAA4; Etats-Unis; Da. 2011; Vol. 412; No. 1; Pp. 371-390; Bibl. 1/4 p.AnglaisKPD 1930+2752 is a short-period pulsating subdwarf B (sdB) star. It is also an ellipsoidal variable with a known binary period of 2.3 h. The companion is most likely a white dwarf and the total mass of the system is close to the Chandresekhar limit. In this paper, we report the results of Whole Earth Telescope (WET) photometric observations during 2003 and a smaller multisite campaign of 2002. From 355 h of WET data, we detect 68 pulsation frequencies and suggest an additional 13 frequencies within a crowded and complex temporal spectrum between 3065 and 6343 μHz (periods between 326 and 157 s). We examine pulsation properties including phase and amplitude stability in an attempt to understand the nature of the pulsation mechanism. We examine a stochastic mechanism by comparing amplitude variations with simulated stochastic data. We also use the binary nature of KPD 1930+2752 for identifying pulsation modes via multiplet structure and a tidally induced pulsation geometry. Our results indicate a complicated pulsation structure that includes short-period (≃16 h) amplitude variability, rotationally split modes, tidally induced modes and some pulsations which are geometrically limited on the sdB star.001E03Sous naine; Etoile B; Binaire serrée; Naine blanche; Observation photométrique; Fréquence oscillation; Multiplet; VariabilitéSubdwarf; B stars; Close binary stars; White dwarf stars; Photometric observation; Oscillation frequency; Multiplets; VariabilitySubenana; Observación fotométrica; Frecuencia oscilación; VariabilidadINIST-2067.35400019280065031011-0151380 001670 Stability to weak dissipative Bresse systemFatiha Alabau BoussouiraUniversite Paul Verlaine-Metz, Laboratoire et Departement de Mathematiques, Bat. A, Ile du Saulcy57045 MetzFRA1 aut.Jaime E. Munoz RiveraNational Laboratory for Scientific Computation, Getúlio Vargas Street, Number 333CEP25651-075, RJ, PetrópolisBRA2 aut.Dilberto Junior Da S. AlmeidaDepartment of Mathematics, Federal University of Pará, Augusto Correa Street, Number 01CEP 66075-110, Belem, ParáBRA3 aut.11-01515912011PASCAL 11-0151591 INISTPascal:11-01515910012290022-247XJ. math. anal. appl.Journal of mathematical analysis and applicationsDissipative systemExponential decayMathematical analysisNumerical stabilitySemigroupWave propagationAnalyse mathématiqueStabilité numériqueSystème dissipatifPropagation ondeSemigroupe37Lxx20MxxDécomposition exponentielle
In this paper we study the Bresse system with frictional dissipation working only on the angle displacement. Our main result is to prove that this dissipative mechanism is enough to stabilize exponentially the whole system provided the velocities of waves propagations are the same. This result is significative only from the mathematical point of view since in practice the velocities of waves propagations are always different. In that direction we show that when the velocities are not the same, the system is not exponentially stable and we prove that the solution in this case goes to zero polynomially, with rates that can be improved by taking more regular initial data. Finally, we give some numerical result to verify our analytical results.
0022-247XJMANAKJ. math. anal. appl.3742Stability to weak dissipative Bresse systemALABAU BOUSSOUIRA (Fatiha)MUNOZ RIVERA (Jaime E.)DA S. ALMEIDA (Dilberto JUNIOR)Universite Paul Verlaine-Metz, Laboratoire et Departement de Mathematiques, Bat. A, Ile du Saulcy57045 MetzFRA1 aut.National Laboratory for Scientific Computation, Getúlio Vargas Street, Number 333CEP25651-075, RJ, PetrópolisBRA2 aut.Department of Mathematics, Federal University of Pará, Augusto Correa Street, Number 01CEP 66075-110, Belem, ParáBRA3 aut.481-4982011ENGINIST29803540001928031301200000© 2011 INIST-CNRS. All rights reserved.11 ref.11-0151591PAJournal of mathematical analysis and applicationsNLDIn this paper we study the Bresse system with frictional dissipation working only on the angle displacement. Our main result is to prove that this dissipative mechanism is enough to stabilize exponentially the whole system provided the velocities of waves propagations are the same. This result is significative only from the mathematical point of view since in practice the velocities of waves propagations are always different. In that direction we show that when the velocities are not the same, the system is not exponentially stable and we prove that the solution in this case goes to zero polynomially, with rates that can be improved by taking more regular initial data. Finally, we give some numerical result to verify our analytical results.001A02E001A02G04001A02D01Analyse mathématique01Mathematical analysis01Análisis matemático01Stabilité numérique17Numerical stability17Estabilidad numérica17Système dissipatif18Dissipative system18Sistema disipativo18Propagation onde19Wave propagation19Propagación onda19Semigroupe20Semigroup20Semigrupo2037LxxINC7020MxxINC71Décomposition exponentielleCD96Exponential decayCD96101OTOOTOPASCAL 11-0151591 INISTStability to weak dissipative Bresse systemALABAU BOUSSOUIRA (Fatiha); MUNOZ RIVERA (Jaime E.); DA S. ALMEIDA (Dilberto JUNIOR)Universite Paul Verlaine-Metz, Laboratoire et Departement de Mathematiques, Bat. A, Ile du Saulcy/57045 Metz/France (1 aut.); National Laboratory for Scientific Computation, Getúlio Vargas Street, Number 333/CEP25651-075, RJ, Petrópolis/Brésil (2 aut.); Department of Mathematics, Federal University of Pará, Augusto Correa Street, Number 01/CEP 66075-110, Belem, Pará/Brésil (3 aut.)
Publication en série; Niveau analytique
Journal of mathematical analysis and applications; ISSN 0022-247X; Coden JMANAK; Pays-Bas; Da. 2011; Vol. 374; No. 2; Pp. 481-498; Bibl. 11 ref.AnglaisIn this paper we study the Bresse system with frictional dissipation working only on the angle displacement. Our main result is to prove that this dissipative mechanism is enough to stabilize exponentially the whole system provided the velocities of waves propagations are the same. This result is significative only from the mathematical point of view since in practice the velocities of waves propagations are always different. In that direction we show that when the velocities are not the same, the system is not exponentially stable and we prove that the solution in this case goes to zero polynomially, with rates that can be improved by taking more regular initial data. Finally, we give some numerical result to verify our analytical results.001A02E; 001A02G04; 001A02D01Analyse mathématique; Stabilité numérique; Système dissipatif; Propagation onde; Semigroupe; 37Lxx; 20Mxx; Décomposition exponentielleMathematical analysis; Numerical stability; Dissipative system; Wave propagation; Semigroup; Exponential decayAnálisis matemático; Estabilidad numérica; Sistema disipativo; Propagación onda; SemigrupoINIST-2980.35400019280313012011-0151591 001671 ARE PSYCHIATRIC RESIDENTS STILL INTERESTED IN PSYCHOANALYSIS? A BRIEF REPORTCristian DamsaFaculty of Medicine University GenevaCHE1 aut.5 aut.6 aut.8 aut.University of Colorado School of MedicineDenver, ColoradoUSA1 aut.Christian BryoisHospital Prangins, Route de Benex1197 PranginsCHE2 aut.Dawn MorelliDepartment & Institute of Psychiatry, Hospital das Clinicas, University of São Paulo Medical SchoolBRA3 aut.Lionel CailholINSERM, CIC 9302 Toulouse, CHU Toulouse, Hôpital PurpanFRA4 aut.Laboratoire du Stress et du Trauma, JE2511, CHU Toulouse, Hôpital CasselarditFRA4 aut.Eric AdamFaculty of Medicine University GenevaCHE1 aut.5 aut.6 aut.8 aut.Adrian ComanFaculty of Medicine University GenevaCHE1 aut.5 aut.6 aut.8 aut.Daniela StamatoiuUniversity of ColoradoDenver, ColoradoUSA7 aut.Coralie LazignacFaculty of Medicine University GenevaCHE1 aut.5 aut.6 aut.8 aut.Jean-Richard FreymannEuropean Federation of Psychoanalysis and Psychoanalytical School of StrasbourgStrasbourgFRA9 aut.11-01527352010PASCAL 11-0152735 INISTPascal:11-0152735001228FRANCIS 11-0152735 INIST0002-9548Am. j. psychoanal.The American journal of psychoanalysisAnalytical psychotherapyAttitudeFocus groupHumanOccupational trainingPersonal experiencePsychiatristPsychoanalysisPsychoanalystReportResident (student)Interne (étudiant)PsychiatrePsychanalyseCompte renduFormation professionnellePsychanalysteExpérience personnelleAttitudePsychothérapie analytiqueGroupe de discussionHomme0002-9548AJPYA8Am. j. psychoanal.704ARE PSYCHIATRIC RESIDENTS STILL INTERESTED IN PSYCHOANALYSIS? A BRIEF REPORTDAMSA (Cristian)BRYOIS (Christian)MORELLI (Dawn)CAILHOL (Lionel)ADAM (Eric)COMAN (Adrian)STAMATOIU (Daniela)LAZIGNAC (Coralie)FREYMANN (Jean-Richard)Faculty of Medicine University GenevaCHE1 aut.5 aut.6 aut.8 aut.University of Colorado School of MedicineDenver, ColoradoUSA1 aut.Hospital Prangins, Route de Benex1197 PranginsCHE2 aut.Department & Institute of Psychiatry, Hospital das Clinicas, University of São Paulo Medical SchoolBRA3 aut.INSERM, CIC 9302 Toulouse, CHU Toulouse, Hôpital PurpanFRA4 aut.Laboratoire du Stress et du Trauma, JE2511, CHU Toulouse, Hôpital CasselarditFRA4 aut.University of ColoradoDenver, ColoradoUSA7 aut.European Federation of Psychoanalysis and Psychoanalytical School of StrasbourgStrasbourgFRA9 aut.386-3912010ENGINIST66733540001950359900500000© 2011 INIST-CNRS. All rights reserved.1/2 p.11-0152735PCCAThe American journal of psychoanalysisGBR002B18H04002A27CInterne (étudiant)01Resident (student)01Interno (estudiante)01Psychiatre02Psychiatrist02Psiquiatra02Psychanalyse03Psychoanalysis03Psicoanálisis03Compte rendu04Report04Informe04Formation professionnelle05Occupational training05Formación profesional05Psychanalyste06Psychoanalyst06Psicoanalista06Expérience personnelle07Personal experience07Experiencia personal07Attitude08Attitude08Actitud08Psychothérapie analytique09Analytical psychotherapy09Psicoterapia analítica09Groupe de discussionNF10Focus groupNF10Grupo de discusiónNF10Homme18Human18Hombre18Personnel sanitaire37Health staff37Personal sanitario37Traitement38Treatment38Tratamiento38101PASCAL 11-0152735 INISTARE PSYCHIATRIC RESIDENTS STILL INTERESTED IN PSYCHOANALYSIS? A BRIEF REPORTDAMSA (Cristian); BRYOIS (Christian); MORELLI (Dawn); CAILHOL (Lionel); ADAM (Eric); COMAN (Adrian); STAMATOIU (Daniela); LAZIGNAC (Coralie); FREYMANN (Jean-Richard)Faculty of Medicine University Geneva/Suisse (1 aut., 5 aut., 6 aut., 8 aut.); University of Colorado School of Medicine/Denver, Colorado/Etats-Unis (1 aut.); Hospital Prangins, Route de Benex/1197 Prangins/Suisse (2 aut.); Department & Institute of Psychiatry, Hospital das Clinicas, University of São Paulo Medical School/Brésil (3 aut.); INSERM, CIC 9302 Toulouse, CHU Toulouse, Hôpital Purpan/France (4 aut.); Laboratoire du Stress et du Trauma, JE2511, CHU Toulouse, Hôpital Casselardit/France (4 aut.); University of Colorado/Denver, Colorado/Etats-Unis (7 aut.); European Federation of Psychoanalysis and Psychoanalytical School of Strasbourg/Strasbourg/France (9 aut.)
Publication en série; Courte communication, note brève; Niveau analytique
The American journal of psychoanalysis; ISSN 0002-9548; Coden AJPYA8; Royaume-Uni; Da. 2010; Vol. 70; No. 4; Pp. 386-391; Bibl. 1/2 p.Anglais002B18H04; 002A27CInterne (étudiant); Psychiatre; Psychanalyse; Compte rendu; Formation professionnelle; Psychanalyste; Expérience personnelle; Attitude; Psychothérapie analytique; Groupe de discussion; HommePersonnel sanitaire; TraitementResident (student); Psychiatrist; Psychoanalysis; Report; Occupational training; Psychoanalyst; Personal experience; Attitude; Analytical psychotherapy; Focus group; HumanHealth staff; TreatmentInterno (estudiante); Psiquiatra; Psicoanálisis; Informe; Formación profesional; Psicoanalista; Experiencia personal; Actitud; Psicoterapia analítica; Grupo de discusión; HombreINIST-6673.35400019503599005011-0152735 001672 Les formes de la mémoire: Art verbal et musique chez les Kuikuro du Haut-Xingu (Brésil)Carlos FaustoUniversidade federal do Rio de Janeiro - Museu nacional Programa de Pós-Graduação em Antropologia SocialRio de janeiroBRA1 aut.2 aut.Bruna FranchettoUniversidade federal do Rio de Janeiro - Museu nacional Programa de Pós-Graduação em Antropologia SocialRio de janeiroBRA1 aut.2 aut.Tommaso MontagnaniEcole des hautes études en sciences sociales - Musée du quai BranlyParisFRA3 aut.11-01530272011FRANCIS 11-0153027 INISTFrancis:11-01530270014690439-4216Homme : (Paris, 1961)L' Homme : (Paris. 1961)AmazoniaAmerindianBrazilEthnomusicologyIndigenous peoplesInformationLearningMemorizingMemoryMusicNarrativeOral traditionOrganizationRepertoryRitual songSouth AmericaTransmissionUpper XinguVerbal artMémoireArt verbalMusiqueAmérindienPeuples indigènesHaut-XinguBrésilAmérique du SudTransmissionApprentissageEthnomusicologieTradition oraleAmazonieRépertoireRécitChant rituelOrganisationInformationMémorisationKuikuro
ON A COUTUME, lorsqu'il est question de mémoire dans les sociétés indigènes amazoniennes, de se représenter un univers très homogène. Par opposition aux traditions pictographiques d'Amérique centrale et du Nord (Severi 2007), à l'écriture maya (Grube 2000) ou aux mnémotechniques andines dont les Khipus sont les meilleurs exemples (Urton 2003 ; Salomon 2001, 2004), l'Amazonie se distinguerait comme le monde de l'oralité par excellence. L'absence d'écriture se conjuguerait ici avec l'absence de tout autre type de support physique à la mémoire et à la transmission du savoir. Récemment, pourtant, Jean-Pierre Chaumeil (2006) a mis en évidence l'existence de systèmes de cordelettes à noeuds chez certains peuples d'Amazonie, ce qu'a confirmé le travail de Pierre Déléage (2009) sur le chapelet aide-mémoire des Émerillons, un groupe tupi-guarani des Guyanes. Si l'on ajoute à ces observations ethnographiques la diversité des données provenant des études sur la préhistoire Les Kuikuro possèdent un vaste répertoire de récits, discours cérémoniels, prières, chants et musiques instrumentales. Les récits sont appris de façon informelle dans le cadre familial, tandis que les autres genres verbaux et musicaux sont transmis d'un maître à un apprenti contre paiement en objets de luxe. Les chants rituels forment un immense répertoire de grande valeur et très difficile à apprendre. Dans certains cas, plus de dix ans sont nécessaires aux musiciens pour arriver à maîtriser un complexe musical dans sa totalité et être en mesure de l'exécuter pendant un rituel. Dans cet article, nous analysons la distribution sociale de la mémoire et les formes internes de structuration de l'information qui permettent la mémorisation d'une si vaste tradition. Notre hypothèse est qu'il existe des formes communes aux arts de la parole et de la musique et que ces formes se fondent sur des principes basiques et productifs qui constituent un véritable art de la mémoire indigène.
0439-4216Homme : (Paris, 1961)197Les formes de la mémoire: Art verbal et musique chez les Kuikuro du Haut-Xingu (Brésil)FAUSTO (Carlos)FRANCHETTO (Bruna)MONTAGNANI (Tommaso)Universidade federal do Rio de Janeiro - Museu nacional Programa de Pós-Graduação em Antropologia SocialRio de janeiroBRA1 aut.2 aut.Ecole des hautes études en sciences sociales - Musée du quai BranlyParisFRA3 aut.41-692011FREengINIST96893540001918934000300000© 2011 INIST-CNRS. All rights reserved.11-0153027PAL' Homme : (Paris. 1961)FRAForms of Memory: The Verbal Arts and Music Among the Kuikuro of upper Xingu (Brazil)ON A COUTUME, lorsqu'il est question de mémoire dans les sociétés indigènes amazoniennes, de se représenter un univers très homogène. Par opposition aux traditions pictographiques d'Amérique centrale et du Nord (Severi 2007), à l'écriture maya (Grube 2000) ou aux mnémotechniques andines dont les Khipus sont les meilleurs exemples (Urton 2003 ; Salomon 2001, 2004), l'Amazonie se distinguerait comme le monde de l'oralité par excellence. L'absence d'écriture se conjuguerait ici avec l'absence de tout autre type de support physique à la mémoire et à la transmission du savoir. Récemment, pourtant, Jean-Pierre Chaumeil (2006) a mis en évidence l'existence de systèmes de cordelettes à noeuds chez certains peuples d'Amazonie, ce qu'a confirmé le travail de Pierre Déléage (2009) sur le chapelet aide-mémoire des Émerillons, un groupe tupi-guarani des Guyanes. Si l'on ajoute à ces observations ethnographiques la diversité des données provenant des études sur la préhistoire Les Kuikuro possèdent un vaste répertoire de récits, discours cérémoniels, prières, chants et musiques instrumentales. Les récits sont appris de façon informelle dans le cadre familial, tandis que les autres genres verbaux et musicaux sont transmis d'un maître à un apprenti contre paiement en objets de luxe. Les chants rituels forment un immense répertoire de grande valeur et très difficile à apprendre. Dans certains cas, plus de dix ans sont nécessaires aux musiciens pour arriver à maîtriser un complexe musical dans sa totalité et être en mesure de l'exécuter pendant un rituel. Dans cet article, nous analysons la distribution sociale de la mémoire et les formes internes de structuration de l'information qui permettent la mémorisation d'une si vaste tradition. Notre hypothèse est qu'il existe des formes communes aux arts de la parole et de la musique et que ces formes se fondent sur des principes basiques et productifs qui constituent un véritable art de la mémoire indigène.52989VII52996VII529Mémoire01Memory01Art verbal02Verbal art02Musique03Music03AmérindienNN04AmerindianNN04Peuples indigènes05Indigenous peoples05Haut-XinguNG06Upper XinguNG06BrésilNG07BrazilNG07Amérique du SudNG08South AmericaNG08Transmission09Transmission09Apprentissage10Learning10Ethnomusicologie11Ethnomusicology11Tradition orale12Oral tradition12AmazonieNG13AmazoniaNG13Répertoire14Repertory14Récit15Narrative15Chant rituel16Ritual song16Organisation17Organization17Information18Information18Mémorisation19Memorizing19KuikuroINC26101FRANCIS 11-0153027 INISTLes formes de la mémoire: Art verbal et musique chez les Kuikuro du Haut-Xingu (Brésil)(Forms of Memory: The Verbal Arts and Music Among the Kuikuro of upper Xingu (Brazil))FAUSTO (Carlos); FRANCHETTO (Bruna); MONTAGNANI (Tommaso)Universidade federal do Rio de Janeiro - Museu nacional Programa de Pós-Graduação em Antropologia Social/Rio de janeiro/Brésil (1 aut., 2 aut.); Ecole des hautes études en sciences sociales - Musée du quai Branly/Paris/France (3 aut.)
Publication en série; Niveau analytique
L' Homme : (Paris. 1961); ISSN 0439-4216; France; Da. 2011; Vol. 197; Pp. 41-69; Abs. anglaisFrançaisON A COUTUME, lorsqu'il est question de mémoire dans les sociétés indigènes amazoniennes, de se représenter un univers très homogène. Par opposition aux traditions pictographiques d'Amérique centrale et du Nord (Severi 2007), à l'écriture maya (Grube 2000) ou aux mnémotechniques andines dont les Khipus sont les meilleurs exemples (Urton 2003 ; Salomon 2001, 2004), l'Amazonie se distinguerait comme le monde de l'oralité par excellence. L'absence d'écriture se conjuguerait ici avec l'absence de tout autre type de support physique à la mémoire et à la transmission du savoir. Récemment, pourtant, Jean-Pierre Chaumeil (2006) a mis en évidence l'existence de systèmes de cordelettes à noeuds chez certains peuples d'Amazonie, ce qu'a confirmé le travail de Pierre Déléage (2009) sur le chapelet aide-mémoire des Émerillons, un groupe tupi-guarani des Guyanes. Si l'on ajoute à ces observations ethnographiques la diversité des données provenant des études sur la préhistoire Les Kuikuro possèdent un vaste répertoire de récits, discours cérémoniels, prières, chants et musiques instrumentales. Les récits sont appris de façon informelle dans le cadre familial, tandis que les autres genres verbaux et musicaux sont transmis d'un maître à un apprenti contre paiement en objets de luxe. Les chants rituels forment un immense répertoire de grande valeur et très difficile à apprendre. Dans certains cas, plus de dix ans sont nécessaires aux musiciens pour arriver à maîtriser un complexe musical dans sa totalité et être en mesure de l'exécuter pendant un rituel. Dans cet article, nous analysons la distribution sociale de la mémoire et les formes internes de structuration de l'information qui permettent la mémorisation d'une si vaste tradition. Notre hypothèse est qu'il existe des formes communes aux arts de la parole et de la musique et que ces formes se fondent sur des principes basiques et productifs qui constituent un véritable art de la mémoire indigène.52989; 52996; 529Mémoire; Art verbal; Musique; Amérindien; Peuples indigènes; Haut-Xingu; Brésil; Amérique du Sud; Transmission; Apprentissage; Ethnomusicologie; Tradition orale; Amazonie; Répertoire; Récit; Chant rituel; Organisation; Information; Mémorisation; KuikuroMemory; Verbal art; Music; Amerindian; Indigenous peoples; Upper Xingu; Brazil; South America; Transmission; Learning; Ethnomusicology; Oral tradition; Amazonia; Repertory; Narrative; Ritual song; Organization; Information; MemorizingINIST-9689.35400019189340003011-0153027 001673 Questioning patients about their adolescent history can identify markers associated with deep infiltrating endometriosisCharles ChapronUniversité Paris Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Ouest, Centre Hospitalier Universitaire Cochin Saint Vincent de Paul, Service de Gynécologie Obstétrique II and Reproductive MedicineFRA1 aut.2 aut.3 aut.5 aut.7 aut.Institut Cochin, Université Paris Descartes, CNRS (UMR 8104)FRA1 aut.4 aut.Inserm, Unité de Recherche U1016FRA1 aut.4 aut.Marie-Christine Lafay-PilletUniversité Paris Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Ouest, Centre Hospitalier Universitaire Cochin Saint Vincent de Paul, Service de Gynécologie Obstétrique II and Reproductive MedicineFRA1 aut.2 aut.3 aut.5 aut.7 aut.Elise MonceauUniversité Paris Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Ouest, Centre Hospitalier Universitaire Cochin Saint Vincent de Paul, Service de Gynécologie Obstétrique II and Reproductive MedicineFRA1 aut.2 aut.3 aut.5 aut.7 aut.Bruno BorgheseInstitut Cochin, Université Paris Descartes, CNRS (UMR 8104)FRA1 aut.4 aut.Inserm, Unité de Recherche U1016FRA1 aut.4 aut.Charlotte NgoUniversité Paris Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Ouest, Centre Hospitalier Universitaire Cochin Saint Vincent de Paul, Service de Gynécologie Obstétrique II and Reproductive MedicineFRA1 aut.2 aut.3 aut.5 aut.7 aut.Université Paris Descartes, Faculté de Médecine, EA 1833, ERTi, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire CochinParisFRA5 aut.Carlos SouzaServiço de Ginecologia e Obstetrícia, Hospital de Clinicas de Porto Alegre, Coordenação de Aperfeiçoamento de Pessoal de Nivel SuperiorPorto AlegreBRA6 aut.Dominique De ZieglerUniversité Paris Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Ouest, Centre Hospitalier Universitaire Cochin Saint Vincent de Paul, Service de Gynécologie Obstétrique II and Reproductive MedicineFRA1 aut.2 aut.3 aut.5 aut.7 aut.11-01541232011PASCAL 11-0154123 INISTPascal:11-01541230012270015-0282Fertil. steril.Fertility and sterilityAdolescentCase historyDiagnosisEndometriosisGynecologyHumanMarkerObstetricsEndométrioseHommeAdolescentHistoriqueMarqueurDiagnosticGynécologieObstétrique
Objective: To investigate whether the clinical history, particularly of the adolescence period, contains markers of deeply infiltrating endometriosis (DIE). Design: Cross-sectional study. Setting: Universitary tertiary referral center. Patient(s): Two hundred twenty-nine patients operated on for endometriosis. Endometriotic lesions were histologically confirmed as non-DIE (superficial peritoneal endometriosis and/or ovarian endometriomas) (n = 131) or DIE (n = 98). Intervention(s): Surgical excision of endometriotic lesions with pathological analysis of each specimens. Main Outcome Measure(s): Epidemiological data, pelvic pain scores, family history of endometriosis, absenteeisrm from school during menstruation, oral contraceptive (OC) pill use. Result(s): Patients with DIE had significantly more positive family history of endometriosis (odds ratio [OR] = 3.2; 95% confidence interval [CI]: 1.2-8.8) and more absenteeism from school during menstruation (OR = 1.7; 95% CI: 1-3). The OC pill use for treating severe primary dysmenorrhea was more frequent in patients with DIE (OR = 4.5; 95% CI: 1.9-10.4). Duration of OC pill use for severe primary dysmenorrhea was longer in patients with DIE (8.4 ± 4.7 years vs. 5.1 ± 3.8 years). There was a higher incidence of OC pill use for severe primary dysmenorrhea before 18 years of age in patients with DIE (OR = 4.2; 95% CI: 1.8-10.0). Conclusion(s): The knowledge of adolescent period history can identify markers that are associated with DIE in patients undergoing surgery for endometriosis.
0015-0282FESTASFertil. steril.953Questioning patients about their adolescent history can identify markers associated with deep infiltrating endometriosisCHAPRON (Charles)LAFAY-PILLET (Marie-Christine)MONCEAU (Elise)BORGHESE (Bruno)NGO (Charlotte)SOUZA (Carlos)DE ZIEGLER (Dominique)Université Paris Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Ouest, Centre Hospitalier Universitaire Cochin Saint Vincent de Paul, Service de Gynécologie Obstétrique II and Reproductive MedicineFRA1 aut.2 aut.3 aut.5 aut.7 aut.Institut Cochin, Université Paris Descartes, CNRS (UMR 8104)FRA1 aut.4 aut.Inserm, Unité de Recherche U1016FRA1 aut.4 aut.Université Paris Descartes, Faculté de Médecine, EA 1833, ERTi, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire CochinParisFRA5 aut.Serviço de Ginecologia e Obstetrícia, Hospital de Clinicas de Porto Alegre, Coordenação de Aperfeiçoamento de Pessoal de Nivel SuperiorPorto AlegreBRA6 aut.877-8812011ENGINIST41203540001937278900600000© 2011 INIST-CNRS. All rights reserved.42 ref.11-0154123PAFertility and sterilityUSAObjective: To investigate whether the clinical history, particularly of the adolescence period, contains markers of deeply infiltrating endometriosis (DIE). Design: Cross-sectional study. Setting: Universitary tertiary referral center. Patient(s): Two hundred twenty-nine patients operated on for endometriosis. Endometriotic lesions were histologically confirmed as non-DIE (superficial peritoneal endometriosis and/or ovarian endometriomas) (n = 131) or DIE (n = 98). Intervention(s): Surgical excision of endometriotic lesions with pathological analysis of each specimens. Main Outcome Measure(s): Epidemiological data, pelvic pain scores, family history of endometriosis, absenteeisrm from school during menstruation, oral contraceptive (OC) pill use. Result(s): Patients with DIE had significantly more positive family history of endometriosis (odds ratio [OR] = 3.2; 95% confidence interval [CI]: 1.2-8.8) and more absenteeism from school during menstruation (OR = 1.7; 95% CI: 1-3). The OC pill use for treating severe primary dysmenorrhea was more frequent in patients with DIE (OR = 4.5; 95% CI: 1.9-10.4). Duration of OC pill use for severe primary dysmenorrhea was longer in patients with DIE (8.4 ± 4.7 years vs. 5.1 ± 3.8 years). There was a higher incidence of OC pill use for severe primary dysmenorrhea before 18 years of age in patients with DIE (OR = 4.2; 95% CI: 1.8-10.0). Conclusion(s): The knowledge of adolescent period history can identify markers that are associated with DIE in patients undergoing surgery for endometriosis.002B20C01Endométriose01Endometriosis01Endometriosis01Homme02Human02Hombre02Adolescent03Adolescent03Adolescente03Historique05Case history05Estudio histórico05Marqueur06Marker06Marcador06Diagnostic08Diagnosis08Diagnóstico08Gynécologie09Gynecology09Ginecología09Obstétrique11Obstetrics11Obstétrico11Pathologie de l'appareil génital femelle37Female genital diseases37Aparato genital hembra patología37Pathologie de l'utérus38Uterine diseases38Utero patología38101OTOOTOPASCAL 11-0154123 INISTQuestioning patients about their adolescent history can identify markers associated with deep infiltrating endometriosisCHAPRON (Charles); LAFAY-PILLET (Marie-Christine); MONCEAU (Elise); BORGHESE (Bruno); NGO (Charlotte); SOUZA (Carlos); DE ZIEGLER (Dominique)Université Paris Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Ouest, Centre Hospitalier Universitaire Cochin Saint Vincent de Paul, Service de Gynécologie Obstétrique II and Reproductive Medicine/France (1 aut., 2 aut., 3 aut., 5 aut., 7 aut.); Institut Cochin, Université Paris Descartes, CNRS (UMR 8104)/France (1 aut., 4 aut.); Inserm, Unité de Recherche U1016/France (1 aut., 4 aut.); Université Paris Descartes, Faculté de Médecine, EA 1833, ERTi, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Cochin/Paris/France (5 aut.); Serviço de Ginecologia e Obstetrícia, Hospital de Clinicas de Porto Alegre, Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior/Porto Alegre/Brésil (6 aut.)
Publication en série; Niveau analytique
Fertility and sterility; ISSN 0015-0282; Coden FESTAS; Etats-Unis; Da. 2011; Vol. 95; No. 3; Pp. 877-881; Bibl. 42 ref.AnglaisObjective: To investigate whether the clinical history, particularly of the adolescence period, contains markers of deeply infiltrating endometriosis (DIE). Design: Cross-sectional study. Setting: Universitary tertiary referral center. Patient(s): Two hundred twenty-nine patients operated on for endometriosis. Endometriotic lesions were histologically confirmed as non-DIE (superficial peritoneal endometriosis and/or ovarian endometriomas) (n = 131) or DIE (n = 98). Intervention(s): Surgical excision of endometriotic lesions with pathological analysis of each specimens. Main Outcome Measure(s): Epidemiological data, pelvic pain scores, family history of endometriosis, absenteeisrm from school during menstruation, oral contraceptive (OC) pill use. Result(s): Patients with DIE had significantly more positive family history of endometriosis (odds ratio [OR] = 3.2; 95% confidence interval [CI]: 1.2-8.8) and more absenteeism from school during menstruation (OR = 1.7; 95% CI: 1-3). The OC pill use for treating severe primary dysmenorrhea was more frequent in patients with DIE (OR = 4.5; 95% CI: 1.9-10.4). Duration of OC pill use for severe primary dysmenorrhea was longer in patients with DIE (8.4 ± 4.7 years vs. 5.1 ± 3.8 years). There was a higher incidence of OC pill use for severe primary dysmenorrhea before 18 years of age in patients with DIE (OR = 4.2; 95% CI: 1.8-10.0). Conclusion(s): The knowledge of adolescent period history can identify markers that are associated with DIE in patients undergoing surgery for endometriosis.002B20C01Endométriose; Homme; Adolescent; Historique; Marqueur; Diagnostic; Gynécologie; ObstétriquePathologie de l'appareil génital femelle; Pathologie de l'utérusEndometriosis; Human; Adolescent; Case history; Marker; Diagnosis; Gynecology; ObstetricsFemale genital diseases; Uterine diseasesEndometriosis; Hombre; Adolescente; Estudio histórico; Marcador; Diagnóstico; Ginecología; ObstétricoINIST-4120.35400019372789006011-0154123 001674 A putative twin-arginine translocation system in the phytopathogenic bacterium Xylella fastidiosaLuciane Prioli CiapinaUnité de glycobiologie structurale et fonctionnelle, UMR USTL-CNRS 8576, IFR147, Université des sciences et technologies de Lille, Bâtiment C959655 VilleneuveFRA1 aut.2 aut.Departamento de Tecnologia, Faculdade de Ciências Agrárias e Veterinária - Unesp/Campus de Jaboticabal, Via de Acesso Professor Paulo Donato Castellane s/n, JaboticabalSão Paulo 14.884-900BRA1 aut.2 aut.Simone Cristina PicchiUnité de glycobiologie structurale et fonctionnelle, UMR USTL-CNRS 8576, IFR147, Université des sciences et technologies de Lille, Bâtiment C959655 VilleneuveFRA1 aut.2 aut.Departamento de Tecnologia, Faculdade de Ciências Agrárias e Veterinária - Unesp/Campus de Jaboticabal, Via de Acesso Professor Paulo Donato Castellane s/n, JaboticabalSão Paulo 14.884-900BRA1 aut.2 aut.Jean-Marie LacroixUnité de glycobiologie structurale et fonctionnelle, UMR USTL-CNRS 8576, IFR147, Université des sciences et technologies de Lille, Bâtiment C959655 VilleneuveFRA3 aut.5 aut.Eliana Gertrudes De Macedo LemosDepartamento de Tecnologia, Faculdade de Ciências Agrárias e Veterinária - Unesp/Campus de Jaboticabal, Via de Acesso Professor Paulo Donato Castellane s/n, JaboticabalSão Paulo 14.884-900BRA4 aut.Carmen Ödberg-FerragutUnité de glycobiologie structurale et fonctionnelle, UMR USTL-CNRS 8576, IFR147, Université des sciences et technologies de Lille, Bâtiment C959655 VilleneuveFRA3 aut.5 aut.11-01542912011PASCAL 11-0154291 INISTPascal:11-01542910012260008-4166Can. j. microbiol.Canadian journal of microbiologyArgininePlant pathogenTwin-arginine translocationPhytopathogèneArginineXylella fastidiosaTranlocation à double arginine
Le système de transport appelé Tat (twin-arginine translocation) a été exploré chez la bactérie phytopathogène Xylella fastidiosa souche CVC 9a5c. La présence des gènes tatA, tatB et tatC dans le génome de X. fastidiosa ainsi qu'une liste de protéines présentant 2 arginines consécutives (appelées twin-arginine) dans leur peptide signal ont suggéré la présence d'un transport Tat fonctionnel chez Xylella. Le transport d'OpgD de X. fastidiosa par le système Tat a été examiné. La séquence signal native ou mutée a été fusionnée à la β-lactamase. L'expression de la fusion avec la séquence signal native conduit à une forte résistance à l'ampicilline chez la souche d'Escherichia coli tat+ mais pas chez la souche mutante. Le remplacement des 2 arginines par 2 lysines supprime le transport de la β-lactamase dans le périplasme de la souche E. coli tat+ démontrant que le substrat OpgD de X. fastidiosa porte une séquence signal reconnue par la machinerie Tat d'E. coli. L'analyse des transcrits par RT-PCR a révélé que les gènes tatA, tatB et tatC sont transcrits en opéron chez X. fastidiosa. Ces gènes ont été clonés. Les tentatives de complémentation chez les mutants nul ou tatC d'E. coli sont restées infructueuses. Par contre, l'expression de l'opéron tat de X. fastidiosa chez le mutant tatB d'E. coli a permis une restauration du transport de la β-lactamase. Des expériences additionnelles indiquent que TatB de X. fastidiosa peut former un complexe hétérologue et fonctionnel avec TatC d'E. coli.
0008-4166CJMIAZCan. j. microbiol.572A putative twin-arginine translocation system in the phytopathogenic bacterium Xylella fastidiosaCIAPINA (Luciane Prioli)PICCHI (Simone Cristina)LACROIX (Jean-Marie)DE MACEDO LEMOS (Eliana Gertrudes)ÖDBERG-FERRAGUT (Carmen)Unité de glycobiologie structurale et fonctionnelle, UMR USTL-CNRS 8576, IFR147, Université des sciences et technologies de Lille, Bâtiment C959655 VilleneuveFRA1 aut.2 aut.Departamento de Tecnologia, Faculdade de Ciências Agrárias e Veterinária - Unesp/Campus de Jaboticabal, Via de Acesso Professor Paulo Donato Castellane s/n, JaboticabalSão Paulo 14.884-900BRA1 aut.2 aut.Unité de glycobiologie structurale et fonctionnelle, UMR USTL-CNRS 8576, IFR147, Université des sciences et technologies de Lille, Bâtiment C959655 VilleneuveFRA3 aut.5 aut.Departamento de Tecnologia, Faculdade de Ciências Agrárias e Veterinária - Unesp/Campus de Jaboticabal, Via de Acesso Professor Paulo Donato Castellane s/n, JaboticabalSão Paulo 14.884-900BRA4 aut.149-1542011ENGfreINIST21843540001937303501000000© 2011 INIST-CNRS. All rights reserved.1 p.3/411-0154291PACanadian journal of microbiologyCANLe système de transport appelé Tat (twin-arginine translocation) a été exploré chez la bactérie phytopathogène Xylella fastidiosa souche CVC 9a5c. La présence des gènes tatA, tatB et tatC dans le génome de X. fastidiosa ainsi qu'une liste de protéines présentant 2 arginines consécutives (appelées twin-arginine) dans leur peptide signal ont suggéré la présence d'un transport Tat fonctionnel chez Xylella. Le transport d'OpgD de X. fastidiosa par le système Tat a été examiné. La séquence signal native ou mutée a été fusionnée à la β-lactamase. L'expression de la fusion avec la séquence signal native conduit à une forte résistance à l'ampicilline chez la souche d'Escherichia coli tat+ mais pas chez la souche mutante. Le remplacement des 2 arginines par 2 lysines supprime le transport de la β-lactamase dans le périplasme de la souche E. coli tat+ démontrant que le substrat OpgD de X. fastidiosa porte une séquence signal reconnue par la machinerie Tat d'E. coli. L'analyse des transcrits par RT-PCR a révélé que les gènes tatA, tatB et tatC sont transcrits en opéron chez X. fastidiosa. Ces gènes ont été clonés. Les tentatives de complémentation chez les mutants nul ou tatC d'E. coli sont restées infructueuses. Par contre, l'expression de l'opéron tat de X. fastidiosa chez le mutant tatB d'E. coli a permis une restauration du transport de la β-lactamase. Des expériences additionnelles indiquent que TatB de X. fastidiosa peut former un complexe hétérologue et fonctionnel avec TatC d'E. coli.002A05B15002A34FPhytopathogène05Plant pathogen05Fitopatógeno05ArginineNKFR14ArginineNKFR14ArgininaNKFR14Xylella fastidiosaINC79Tranlocation à double arginineCD96Twin-arginine translocationCD96Bactérie13Bacteria13Bacteria13Aminoacide16Aminoacid16Aminoácido16XanthomonadaceaeINC80GammaproteobacteriaINC91ProteobacteriaINC92101OTOOTOPASCAL 11-0154291 INISTA putative twin-arginine translocation system in the phytopathogenic bacterium Xylella fastidiosaCIAPINA (Luciane Prioli); PICCHI (Simone Cristina); LACROIX (Jean-Marie); DE MACEDO LEMOS (Eliana Gertrudes); ÖDBERG-FERRAGUT (Carmen)Unité de glycobiologie structurale et fonctionnelle, UMR USTL-CNRS 8576, IFR147, Université des sciences et technologies de Lille, Bâtiment C9/59655 Villeneuve/France (1 aut., 2 aut.); Departamento de Tecnologia, Faculdade de Ciências Agrárias e Veterinária - Unesp/Campus de Jaboticabal, Via de Acesso Professor Paulo Donato Castellane s/n, Jaboticabal/São Paulo 14.884-900/Brésil (1 aut., 2 aut.); Unité de glycobiologie structurale et fonctionnelle, UMR USTL-CNRS 8576, IFR147, Université des sciences et technologies de Lille, Bâtiment C9/59655 Villeneuve/France (3 aut., 5 aut.); Departamento de Tecnologia, Faculdade de Ciências Agrárias e Veterinária - Unesp/Campus de Jaboticabal, Via de Acesso Professor Paulo Donato Castellane s/n, Jaboticabal/São Paulo 14.884-900/Brésil (4 aut.)
Publication en série; Niveau analytique
Canadian journal of microbiology; ISSN 0008-4166; Coden CJMIAZ; Canada; Da. 2011; Vol. 57; No. 2; Pp. 149-154; Abs. français; Bibl. 1 p.3/4AnglaisLe système de transport appelé Tat (twin-arginine translocation) a été exploré chez la bactérie phytopathogène Xylella fastidiosa souche CVC 9a5c. La présence des gènes tatA, tatB et tatC dans le génome de X. fastidiosa ainsi qu'une liste de protéines présentant 2 arginines consécutives (appelées twin-arginine) dans leur peptide signal ont suggéré la présence d'un transport Tat fonctionnel chez Xylella. Le transport d'OpgD de X. fastidiosa par le système Tat a été examiné. La séquence signal native ou mutée a été fusionnée à la β-lactamase. L'expression de la fusion avec la séquence signal native conduit à une forte résistance à l'ampicilline chez la souche d'Escherichia coli tat+ mais pas chez la souche mutante. Le remplacement des 2 arginines par 2 lysines supprime le transport de la β-lactamase dans le périplasme de la souche E. coli tat+ démontrant que le substrat OpgD de X. fastidiosa porte une séquence signal reconnue par la machinerie Tat d'E. coli. L'analyse des transcrits par RT-PCR a révélé que les gènes tatA, tatB et tatC sont transcrits en opéron chez X. fastidiosa. Ces gènes ont été clonés. Les tentatives de complémentation chez les mutants nul ou tatC d'E. coli sont restées infructueuses. Par contre, l'expression de l'opéron tat de X. fastidiosa chez le mutant tatB d'E. coli a permis une restauration du transport de la β-lactamase. Des expériences additionnelles indiquent que TatB de X. fastidiosa peut former un complexe hétérologue et fonctionnel avec TatC d'E. coli.002A05B15; 002A34FPhytopathogène; Arginine; Xylella fastidiosa; Tranlocation à double arginineBactérie; Aminoacide; Xanthomonadaceae; Gammaproteobacteria; ProteobacteriaPlant pathogen; Arginine; Twin-arginine translocationBacteria; AminoacidFitopatógeno; ArgininaINIST-2184.35400019373035010011-0154291 001675 A global experiment suggests climate warming will not accelerate litter decomposition in streams but might reduce carbon sequestrationLuz BoyeroWetland Ecology Department, Doñana Biological Station-CSIC, Avda Americo Vespucio s/n41092 SevillaESP1 aut.School of Marine and Tropical Biology, James Cook UniversityTownsville, Qld 4811AUS1 aut.2 aut.Richard G. PersonSchool of Marine and Tropical Biology, James Cook UniversityTownsville, Qld 4811AUS1 aut.2 aut.Mark O. GessnerDepartment of Aquatic Ecology, Eawag: Swiss Federal Institute of Aquatic Science and Technology, Überlandstrasse 1338600 DubendorfCHE3 aut.12 aut.30 aut.Institute of Integrative Biology, ETH ZürichZurichCHE3 aut.12 aut.Leon A. BarmutaFreshwater Ecology Group, School of Zoology, University of Tasmania, Private Bag 5, HobartTasmania 7001AUS4 aut.29 aut.Veronica FerreiraIMAR-CMA & Department Life Sciences, University of Coimbra3001-401 CoimbraPRT5 aut.6 aut.31 aut.Manuel A. S. GracaIMAR-CMA & Department Life Sciences, University of Coimbra3001-401 CoimbraPRT5 aut.6 aut.31 aut.David DudgeonSchool of Biological Sciences, The University of Hong KongHKG7 aut.Andrew J. BoultonEcosystem Management, School of Environmental and Rural Science, University of New EnglandArmidale, NSW 2350AUS8 aut.16 aut.Marcos CallistoLaboratorio de Ecologia de Bentos, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 48630161-970 Belo Horizonte, MGBRA9 aut.24 aut.25 aut.Eric ChauvetUniversité de Toulouse, UPS, INPT, EcoLab, 29 rue Jeanne Marvig31055 ToulouseFRA10 aut.27 aut.Julie E. HelsonSurface and Groundwater Ecology Research Group, Department of Biological Sciences, University of Toronto at Scarborough, 1265 Military TrailToronto, ON M1C1A4CAN11 aut.Andreas BruderDepartment of Aquatic Ecology, Eawag: Swiss Federal Institute of Aquatic Science and Technology, Überlandstrasse 1338600 DubendorfCHE3 aut.12 aut.30 aut.Institute of Integrative Biology, ETH ZürichZurichCHE3 aut.12 aut.Ricardo J. AlbarinoLaboratorio de Limnologia, INIBIOMA, Universidad Nacional del Comahue-CONICETBarilocheARG13 aut.32 aut.34 aut.Catherine M. YuleSchool of Science, Monash University, Jalan Lagoon Selatan, Bandar Sunway46150 SelangorMYS14 aut.26 aut.Muthukumarasamy ArunachalamSri Paramakalyani Centre for Environmental Sciences, Manonmainam Sundaranar UniversityAlwarkuruchi, Tamil NaduIND15 aut.Judy N. DaviesEcosystem Management, School of Environmental and Rural Science, University of New EnglandArmidale, NSW 2350AUS8 aut.16 aut.Ricardo FigueroaAquatic Systems Research Unit, Environmental Science Center EULA-Chile, University of Concepción, PO Box 160-CConcepciónCHL17 aut.Alexander S. FleckerDepartment of Ecology & Evolutionary Biology, E 203 Corson Hall, Cornell UniversityIthaca, NY 14853USA18 aut.35 aut.Alonso RamirezInstitute for Tropical Ecosystem Studies, University of Puerto Rico, PO Box 70377San Juan, PR 00936USA19 aut.Russell G. DeathInstitute of Natural Resources, Ecology PN624, Private Bag 11-222Palmerston NorthNZL20 aut.Tomoya IwataFaculty of Engineering, University of Yamanashi, 4-3-11 TakedaKofu 400-8511JPN21 aut.Jude M. MathookoDepartment of Biological Sciences, Egerton University, PO Box 536EgertonKEN22 aut.28 aut.Catherine MathuriauCentro de Investigaciones en Ecosistemas, Antigua Carretera a Pátzcuaro N° 8701, Ex-Hacienda de San Jose de la Huerta, CP 58190Morelia, MichoacánMEX23 aut.José F. Jr GoncalvesLaboratorio de Ecologia de Bentos, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 48630161-970 Belo Horizonte, MGBRA9 aut.24 aut.25 aut.Marcelo S. MorettiLaboratorio de Ecologia de Bentos, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 48630161-970 Belo Horizonte, MGBRA9 aut.24 aut.25 aut.Tajang JinggutSchool of Science, Monash University, Jalan Lagoon Selatan, Bandar Sunway46150 SelangorMYS14 aut.26 aut.Sylvain LamotheUniversité de Toulouse, UPS, INPT, EcoLab, 29 rue Jeanne Marvig31055 ToulouseFRA10 aut.27 aut.CNRS, EcoLab31055 ToulouseFRA27 aut.Charles M ErimbaDepartment of Biological Sciences, Egerton University, PO Box 536EgertonKEN22 aut.28 aut.Lavenia RatnarajahFreshwater Ecology Group, School of Zoology, University of Tasmania, Private Bag 5, HobartTasmania 7001AUS4 aut.29 aut.Markus H. SchindlerDepartment of Aquatic Ecology, Eawag: Swiss Federal Institute of Aquatic Science and Technology, Überlandstrasse 1338600 DubendorfCHE3 aut.12 aut.30 aut.José CastelaIMAR-CMA & Department Life Sciences, University of Coimbra3001-401 CoimbraPRT5 aut.6 aut.31 aut.Leonardo M. BuriaLaboratorio de Limnologia, INIBIOMA, Universidad Nacional del Comahue-CONICETBarilocheARG13 aut.32 aut.34 aut.Aydeé CornejoSección de Entomologia, Instituto Conmemorativo Gorgas de Estudios de la Salud, Avenida Justo Arosemena & Calle 350816-02593, Panama CityPAN33 aut.Programa Centroamericano de Maestria en Entomologia, Universidad de PanamáPanama CityPAN33 aut.Veronica D. VillanuevaLaboratorio de Limnologia, INIBIOMA, Universidad Nacional del Comahue-CONICETBarilocheARG13 aut.32 aut.34 aut.Derek C. WestDepartment of Ecology & Evolutionary Biology, E 203 Corson Hall, Cornell UniversityIthaca, NY 14853USA18 aut.35 aut.11-01571202011PASCAL 11-0157120 INISTPascal:11-01571200012251461-023XEcol. lett. : (Print)Ecology letters : (Print)Carbon cycleCarbon sequestrationClimate changeDecomposerDecompositionDetritivorousLatitudinal gradientLitterMicroorganismStreamTemperatureWarmingChangement climatiqueRéchauffementLitièreDécompositionCours eauSéquestration carboneCycle carboneDétritivoreGradient latitudinalMicroorganismeDécomposeurTempérature
The decomposition of plant litter is one of the most important ecosystem processes in the biosphere and is particularly sensitive to climate warming. Aquatic ecosystems are well suited to studying warming effects on decomposition because the otherwise confounding influence of moisture is constant. By using a latitudinal temperature gradient in an unprecedented global experiment in streams, we found that climate warming will likely hasten microbial litter decomposition and produce an equivalent decline in detritivore-mediated decomposition rates. As a result, overall decomposition rates should remain unchanged. Nevertheless, the process would be profoundly altered, because the shift in importance from detritivores to microbes in warm climates would likely increase CO2 production and decrease the generation and sequestration of recalcitrant organic particles. In view of recent estimates showing that inland waters are a significant component of the global carbon cycle, this implies consequences for global biogeochemistry and a possible positive climate feedback.
1461-023XEcol. lett. : (Print)143A global experiment suggests climate warming will not accelerate litter decomposition in streams but might reduce carbon sequestrationBOYERO (Luz)PERSON (Richard G.)GESSNER (Mark O.)BARMUTA (Leon A.)FERREIRA (Veronica)GRACA (Manuel A. S.)DUDGEON (David)BOULTON (Andrew J.)CALLISTO (Marcos)CHAUVET (Eric)HELSON (Julie E.)BRUDER (Andreas)ALBARINO (Ricardo J.)YULE (Catherine M.)ARUNACHALAM (Muthukumarasamy)DAVIES (Judy N.)FIGUEROA (Ricardo)FLECKER (Alexander S.)RAMIREZ (Alonso)DEATH (Russell G.)IWATA (Tomoya)MATHOOKO (Jude M.)MATHURIAU (Catherine)GONCALVES (José F. JR)MORETTI (Marcelo S.)JINGGUT (Tajang)LAMOTHE (Sylvain)M'ERIMBA (Charles)RATNARAJAH (Lavenia)SCHINDLER (Markus H.)CASTELA (José)BURIA (Leonardo M.)CORNEJO (Aydeé)VILLANUEVA (Veronica D.)WEST (Derek C.)Wetland Ecology Department, Doñana Biological Station-CSIC, Avda Americo Vespucio s/n41092 SevillaESP1 aut.School of Marine and Tropical Biology, James Cook UniversityTownsville, Qld 4811AUS1 aut.2 aut.Department of Aquatic Ecology, Eawag: Swiss Federal Institute of Aquatic Science and Technology, Überlandstrasse 1338600 DubendorfCHE3 aut.12 aut.30 aut.Institute of Integrative Biology, ETH ZürichZurichCHE3 aut.12 aut.Freshwater Ecology Group, School of Zoology, University of Tasmania, Private Bag 5, HobartTasmania 7001AUS4 aut.29 aut.IMAR-CMA & Department Life Sciences, University of Coimbra3001-401 CoimbraPRT5 aut.6 aut.31 aut.School of Biological Sciences, The University of Hong KongHKG7 aut.Ecosystem Management, School of Environmental and Rural Science, University of New EnglandArmidale, NSW 2350AUS8 aut.16 aut.Laboratorio de Ecologia de Bentos, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 48630161-970 Belo Horizonte, MGBRA9 aut.24 aut.25 aut.Université de Toulouse, UPS, INPT, EcoLab, 29 rue Jeanne Marvig31055 ToulouseFRA10 aut.27 aut.CNRS, EcoLab31055 ToulouseFRA27 aut.Surface and Groundwater Ecology Research Group, Department of Biological Sciences, University of Toronto at Scarborough, 1265 Military TrailToronto, ON M1C1A4CAN11 aut.Laboratorio de Limnologia, INIBIOMA, Universidad Nacional del Comahue-CONICETBarilocheARG13 aut.32 aut.34 aut.School of Science, Monash University, Jalan Lagoon Selatan, Bandar Sunway46150 SelangorMYS14 aut.26 aut.Sri Paramakalyani Centre for Environmental Sciences, Manonmainam Sundaranar UniversityAlwarkuruchi, Tamil NaduIND15 aut.Aquatic Systems Research Unit, Environmental Science Center EULA-Chile, University of Concepción, PO Box 160-CConcepciónCHL17 aut.Department of Ecology & Evolutionary Biology, E 203 Corson Hall, Cornell UniversityIthaca, NY 14853USA18 aut.35 aut.Institute for Tropical Ecosystem Studies, University of Puerto Rico, PO Box 70377San Juan, PR 00936USA19 aut.Institute of Natural Resources, Ecology PN624, Private Bag 11-222Palmerston NorthNZL20 aut.Faculty of Engineering, University of Yamanashi, 4-3-11 TakedaKofu 400-8511JPN21 aut.Department of Biological Sciences, Egerton University, PO Box 536EgertonKEN22 aut.28 aut.Centro de Investigaciones en Ecosistemas, Antigua Carretera a Pátzcuaro N° 8701, Ex-Hacienda de San Jose de la Huerta, CP 58190Morelia, MichoacánMEX23 aut.Sección de Entomologia, Instituto Conmemorativo Gorgas de Estudios de la Salud, Avenida Justo Arosemena & Calle 350816-02593, Panama CityPAN33 aut.Programa Centroamericano de Maestria en Entomologia, Universidad de PanamáPanama CityPAN33 aut.289-2942011ENGINIST278793540001937324101100000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0157120PCRAEcology letters : (Print)GBRThe decomposition of plant litter is one of the most important ecosystem processes in the biosphere and is particularly sensitive to climate warming. Aquatic ecosystems are well suited to studying warming effects on decomposition because the otherwise confounding influence of moisture is constant. By using a latitudinal temperature gradient in an unprecedented global experiment in streams, we found that climate warming will likely hasten microbial litter decomposition and produce an equivalent decline in detritivore-mediated decomposition rates. As a result, overall decomposition rates should remain unchanged. Nevertheless, the process would be profoundly altered, because the shift in importance from detritivores to microbes in warm climates would likely increase CO2 production and decrease the generation and sequestration of recalcitrant organic particles. In view of recent estimates showing that inland waters are a significant component of the global carbon cycle, this implies consequences for global biogeochemistry and a possible positive climate feedback.002A14B01001E02D10Changement climatique01Climate change01Cambio climático01Réchauffement02Warming02Calefacción02LitièreNT03LitterNT03HojarascaNT03Décomposition04Decomposition04Descomposición04Cours eau05Stream05Curso agua05Séquestration carbone06Carbon sequestration06Secuestro carbono06Cycle carbone07Carbon cycle07Ciclo carbono07Détritivore08Detritivorous08Detritivoro08Gradient latitudinal09Latitudinal gradient09Gradiente latitudinal09Microorganisme10Microorganism10Microorganismo10Décomposeur11Decomposer11Descomponedor11Température12Temperature12Temperatura12Climatologie dynamiqueDynamical climatologyClimatología dinámica101OTOOTOPASCAL 11-0157120 INISTA global experiment suggests climate warming will not accelerate litter decomposition in streams but might reduce carbon sequestrationBOYERO (Luz); PERSON (Richard G.); GESSNER (Mark O.); BARMUTA (Leon A.); FERREIRA (Veronica); GRACA (Manuel A. S.); DUDGEON (David); BOULTON (Andrew J.); CALLISTO (Marcos); CHAUVET (Eric); HELSON (Julie E.); BRUDER (Andreas); ALBARINO (Ricardo J.); YULE (Catherine M.); ARUNACHALAM (Muthukumarasamy); DAVIES (Judy N.); FIGUEROA (Ricardo); FLECKER (Alexander S.); RAMIREZ (Alonso); DEATH (Russell G.); IWATA (Tomoya); MATHOOKO (Jude M.); MATHURIAU (Catherine); GONCALVES (José F. JR); MORETTI (Marcelo S.); JINGGUT (Tajang); LAMOTHE (Sylvain); M'ERIMBA (Charles); RATNARAJAH (Lavenia); SCHINDLER (Markus H.); CASTELA (José); BURIA (Leonardo M.); CORNEJO (Aydeé); VILLANUEVA (Veronica D.); WEST (Derek C.)Wetland Ecology Department, Doñana Biological Station-CSIC, Avda Americo Vespucio s/n/41092 Sevilla/Espagne (1 aut.); School of Marine and Tropical Biology, James Cook University/Townsville, Qld 4811/Australie (1 aut., 2 aut.); Department of Aquatic Ecology, Eawag: Swiss Federal Institute of Aquatic Science and Technology, Überlandstrasse 133/8600 Dubendorf/Suisse (3 aut., 12 aut., 30 aut.); Institute of Integrative Biology, ETH Zürich/Zurich/Suisse (3 aut., 12 aut.); Freshwater Ecology Group, School of Zoology, University of Tasmania, Private Bag 5, Hobart/Tasmania 7001/Australie (4 aut., 29 aut.); IMAR-CMA & Department Life Sciences, University of Coimbra/3001-401 Coimbra/Portugal (5 aut., 6 aut., 31 aut.); School of Biological Sciences, The University of Hong Kong/Hong-Kong (7 aut.); Ecosystem Management, School of Environmental and Rural Science, University of New England/Armidale, NSW 2350/Australie (8 aut., 16 aut.); Laboratorio de Ecologia de Bentos, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 486/30161-970 Belo Horizonte, MG/Brésil (9 aut., 24 aut., 25 aut.); Université de Toulouse, UPS, INPT, EcoLab, 29 rue Jeanne Marvig/31055 Toulouse/France (10 aut., 27 aut.); CNRS, EcoLab/31055 Toulouse/France (27 aut.); Surface and Groundwater Ecology Research Group, Department of Biological Sciences, University of Toronto at Scarborough, 1265 Military Trail/Toronto, ON M1C1A4/Canada (11 aut.); Laboratorio de Limnologia, INIBIOMA, Universidad Nacional del Comahue-CONICET/Bariloche/Argentine (13 aut., 32 aut., 34 aut.); School of Science, Monash University, Jalan Lagoon Selatan, Bandar Sunway/46150 Selangor/Malaisie (14 aut., 26 aut.); Sri Paramakalyani Centre for Environmental Sciences, Manonmainam Sundaranar University/Alwarkuruchi, Tamil Nadu/Inde (15 aut.); Aquatic Systems Research Unit, Environmental Science Center EULA-Chile, University of Concepción, PO Box 160-C/Concepción/Chili (17 aut.); Department of Ecology & Evolutionary Biology, E 203 Corson Hall, Cornell University/Ithaca, NY 14853/Etats-Unis (18 aut., 35 aut.); Institute for Tropical Ecosystem Studies, University of Puerto Rico, PO Box 70377/San Juan, PR 00936/Etats-Unis (19 aut.); Institute of Natural Resources, Ecology PN624, Private Bag 11-222/Palmerston North/Nouvelle-Zélande (20 aut.); Faculty of Engineering, University of Yamanashi, 4-3-11 Takeda/Kofu 400-8511/Japon (21 aut.); Department of Biological Sciences, Egerton University, PO Box 536/Egerton/Kenya (22 aut., 28 aut.); Centro de Investigaciones en Ecosistemas, Antigua Carretera a Pátzcuaro N° 8701, Ex-Hacienda de San Jose de la Huerta, CP 58190/Morelia, Michoacán/Mexique (23 aut.); Sección de Entomologia, Instituto Conmemorativo Gorgas de Estudios de la Salud, Avenida Justo Arosemena & Calle 35/0816-02593, Panama City/Panama (33 aut.); Programa Centroamericano de Maestria en Entomologia, Universidad de Panamá/Panama City/Panama (33 aut.)
Publication en série; Correspondance, lettre; Niveau analytique
Ecology letters : (Print); ISSN 1461-023X; Royaume-Uni; Da. 2011; Vol. 14; No. 3; Pp. 289-294; Bibl. 3/4 p.AnglaisThe decomposition of plant litter is one of the most important ecosystem processes in the biosphere and is particularly sensitive to climate warming. Aquatic ecosystems are well suited to studying warming effects on decomposition because the otherwise confounding influence of moisture is constant. By using a latitudinal temperature gradient in an unprecedented global experiment in streams, we found that climate warming will likely hasten microbial litter decomposition and produce an equivalent decline in detritivore-mediated decomposition rates. As a result, overall decomposition rates should remain unchanged. Nevertheless, the process would be profoundly altered, because the shift in importance from detritivores to microbes in warm climates would likely increase CO2 production and decrease the generation and sequestration of recalcitrant organic particles. In view of recent estimates showing that inland waters are a significant component of the global carbon cycle, this implies consequences for global biogeochemistry and a possible positive climate feedback.002A14B01; 001E02D10Changement climatique; Réchauffement; Litière; Décomposition; Cours eau; Séquestration carbone; Cycle carbone; Détritivore; Gradient latitudinal; Microorganisme; Décomposeur; TempératureClimatologie dynamiqueClimate change; Warming; Litter; Decomposition; Stream; Carbon sequestration; Carbon cycle; Detritivorous; Latitudinal gradient; Microorganism; Decomposer; TemperatureDynamical climatologyCambio climático; Calefacción; Hojarasca; Descomposición; Curso agua; Secuestro carbono; Ciclo carbono; Detritivoro; Gradiente latitudinal; Microorganismo; Descomponedor; TemperaturaINIST-27879.35400019373241011011-0157120 001676 Pandemic influenza A H1N1/09 virus infection in hematopoietic SCT recipientD. A. BastosHospital Sírio-LibanêsSao PauloBRA1 aut.6 aut.C. A. RodriguesBMT Unit, Hospital Sírio-LibanêsSao PauloBRA2 aut.3 aut.P. PatahBMT Unit, Hospital Sírio-LibanêsSao PauloBRA2 aut.3 aut.E. G. KallasDivision of Clinical Immunology and Allergy, Medical School, University of Sao PauloSao PauloBRA4 aut.V. RochaEurocord/ Saint-Louis HospitalParisFRA5 aut.Y. NovisHospital Sírio-LibanêsSao PauloBRA1 aut.6 aut.11-01574332011PASCAL 11-0157433 INISTPascal:11-01574330012240268-3369Bone marrow transplant. : (Basingstoke)Bone marrow transplantation : (Basingstoke)H1N1 influenzaHematologyHematopoietic stem cell transplantationInfluenza AInfluenza A virusInfluenzavirus ARecipientGrippe AInfluenzavirus AVirus grippal AReceveurHématologieGrippe H1N1Greffe de cellules souches hématopoïétiques0268-3369BMTRE9Bone marrow transplant. : (Basingstoke)463Pandemic influenza A H1N1/09 virus infection in hematopoietic SCT recipientBASTOS (D. A.)RODRIGUES (C. A.)PATAH (P.)KALLAS (E. G.)ROCHA (V.)NOVIS (Y.)Hospital Sírio-LibanêsSao PauloBRA1 aut.6 aut.BMT Unit, Hospital Sírio-LibanêsSao PauloBRA2 aut.3 aut.Division of Clinical Immunology and Allergy, Medical School, University of Sao PauloSao PauloBRA4 aut.Eurocord/ Saint-Louis HospitalParisFRA5 aut.467-4682011ENGINIST211763540001907548102800000© 2011 INIST-CNRS. All rights reserved.9 ref.11-0157433PLTABone marrow transplantation : (Basingstoke)GBR002B27D02002B05C02CGrippe A01Influenza A01Gripe A01Influenzavirus ANW02Influenzavirus ANW02Influenzavirus ANW02Virus grippal ANW03Influenza A virusNW03Influenza A virusNW03Receveur05Recipient05Receptor05Hématologie06Hematology06Hematología06Grippe H1N1CD96H1N1 influenzaCD96Gripe H1N1CD96Greffe de cellules souches hématopoïétiquesCD97Hematopoietic stem cell transplantationCD97Injerto de célula primitiva hematopoyéticaCD97ViroseViral diseaseVirosisInfectionInfectionInfecciónOrthomyxoviridaeNWOrthomyxoviridaeNWOrthomyxoviridaeNWVirusNWVirusNWVirusNWPathologie de l'appareil respiratoire37Respiratory disease37Aparato respiratorio patología37101OTOOTOPASCAL 11-0157433 INISTPandemic influenza A H1N1/09 virus infection in hematopoietic SCT recipientBASTOS (D. A.); RODRIGUES (C. A.); PATAH (P.); KALLAS (E. G.); ROCHA (V.); NOVIS (Y.)Hospital Sírio-Libanês/Sao Paulo/Brésil (1 aut., 6 aut.); BMT Unit, Hospital Sírio-Libanês/Sao Paulo/Brésil (2 aut., 3 aut.); Division of Clinical Immunology and Allergy, Medical School, University of Sao Paulo/Sao Paulo/Brésil (4 aut.); Eurocord/ Saint-Louis Hospital/Paris/France (5 aut.)
Publication en série; Lettre à l'éditeur; Niveau analytique
Bone marrow transplantation : (Basingstoke); ISSN 0268-3369; Coden BMTRE9; Royaume-Uni; Da. 2011; Vol. 46; No. 3; Pp. 467-468; Bibl. 9 ref.Anglais002B27D02; 002B05C02CGrippe A; Influenzavirus A; Virus grippal A; Receveur; Hématologie; Grippe H1N1; Greffe de cellules souches hématopoïétiquesVirose; Infection; Orthomyxoviridae; Virus; Pathologie de l'appareil respiratoireInfluenza A; Influenzavirus A; Influenza A virus; Recipient; Hematology; H1N1 influenza; Hematopoietic stem cell transplantationViral disease; Infection; Orthomyxoviridae; Virus; Respiratory diseaseGripe A; Influenzavirus A; Influenza A virus; Receptor; Hematología; Gripe H1N1; Injerto de célula primitiva hematopoyéticaINIST-21176.35400019075481028011-0157433 001677 The genome of Theobroma cacaoXavier ArgoutCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Jerome SalseInstitut National de la Recherche Agronomique UMR 1095Clermont-FerrandFRA2 aut.11 aut.12 aut.Jean-Marc AuryCommissariat à l'Energie Antomique (CEA), Institut de Génomique (IG), GenoscopeEvryFRA3 aut.14 aut.59 aut.Centre National de Recherche Scientifique (CNRS), UMR 8030, CP5706EvryFRA3 aut.14 aut.59 aut.Université d'EvryEFRA3 aut.14 aut.59 aut.Mark J. GuiltinanPenn State University, Department of Horticulture and the Huck Institutes of the Life SciencesUniversity Park, PennsylvaniaUSA4 aut.10 aut.Penn State University, Plant Biology Graduate Program and the Huck Institutes of the Life SciencesUniversity Park, PennsylvaniaUSA4 aut.29 aut.38 aut.Gaetan DrocCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Jerome GouzyInstitut National de la Recherche Agronomique (INRA)-CNRS Laboratoire des Interactions Plantes Micro-organismes (LIPM)Castanet TolosanFRA6 aut.24 aut.Mathilde AllegreCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Cristian ChaparroUMR 5096 CNRS-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD), Laboratoire Génome et Développement des PlantesPerpignanFRA8 aut.18 aut.19 aut.58 aut.Thierry LegavreCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Siela N. MaximovaPenn State University, Department of Horticulture and the Huck Institutes of the Life SciencesUniversity Park, PennsylvaniaUSA4 aut.10 aut.Michael AbroukInstitut National de la Recherche Agronomique UMR 1095Clermont-FerrandFRA2 aut.11 aut.12 aut.Florent MuratInstitut National de la Recherche Agronomique UMR 1095Clermont-FerrandFRA2 aut.11 aut.12 aut.Olivier FouetCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Julie PoulainCommissariat à l'Energie Antomique (CEA), Institut de Génomique (IG), GenoscopeEvryFRA3 aut.14 aut.59 aut.Centre National de Recherche Scientifique (CNRS), UMR 8030, CP5706EvryFRA3 aut.14 aut.59 aut.Université d'EvryEFRA3 aut.14 aut.59 aut.Manuel RuizCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Yolande RoguetCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Maguy Rodier-GoudCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Jose Fernandes Barbosa-NetoUMR 5096 CNRS-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD), Laboratoire Génome et Développement des PlantesPerpignanFRA8 aut.18 aut.19 aut.58 aut.Francois SabotUMR 5096 CNRS-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD), Laboratoire Génome et Développement des PlantesPerpignanFRA8 aut.18 aut.19 aut.58 aut.Dave KudrnaArizona Genomics Institute and School of Plant Sciences, University of ArizonaTucson, ArizonaUSA20 aut.21 aut.41 aut.42 aut.54 aut.Jetty Siva S. AmmirajuArizona Genomics Institute and School of Plant Sciences, University of ArizonaTucson, ArizonaUSA20 aut.21 aut.41 aut.42 aut.54 aut.Stephan C. SchusterPenn State University, Department of Biochemistry and Molecular BiologyUniversity Park, PennsylvaniaUSA22 aut.John E. CarlsonPenn State University, the School of Forest Resources and the Huck Institutes of the Life SciencesUniversity Park, PennsylvaniaUSA23 aut.The Department of Bioenergy Science and Technology (WCU), Chonnam National UniversityBuk-Gu, GwangjuKOR23 aut.Erika SalletInstitut National de la Recherche Agronomique (INRA)-CNRS Laboratoire des Interactions Plantes Micro-organismes (LIPM)Castanet TolosanFRA6 aut.24 aut.Thomas SchiexUnité de Biométrie et d'Intelligence Artificielle (UBIA), UR875 INRACastanet TolosanFRA25 aut.Anne DievartCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Melissa KramerCold Spring Harbor LaboratoryCold Spring Harbor, New YorkUSA27 aut.28 aut.38 aut.55 aut.Laura GelleyCold Spring Harbor LaboratoryCold Spring Harbor, New YorkUSA27 aut.28 aut.38 aut.55 aut.ZI SHIPenn State University, Plant Biology Graduate Program and the Huck Institutes of the Life SciencesUniversity Park, PennsylvaniaUSA4 aut.29 aut.38 aut.Aurélie BerardINRA, UR 1279 Etude du Polymorphisme des Génomes Végétaux, CEA Institut de Génomique, Centre National de Génotypage, CP5724EvryFRA30 aut.50 aut.Christopher ViotCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Michel BoccaraCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Ange Marie RisterucciCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Valentin GuignonCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Xavier SabauCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Michael J. AxtellPenn State University, Bioinformatics and Genomics PhD Program and Department of BiologyUniversity Park, PennsylvaniaUSA36 aut.37 aut.ZHAORONG MAPenn State University, Bioinformatics and Genomics PhD Program and Department of BiologyUniversity Park, PennsylvaniaUSA36 aut.37 aut.YUFAN ZHANGPenn State University, Plant Biology Graduate Program and the Huck Institutes of the Life SciencesUniversity Park, PennsylvaniaUSA4 aut.29 aut.38 aut.Cold Spring Harbor LaboratoryCold Spring Harbor, New YorkUSA27 aut.28 aut.38 aut.55 aut.Spencer BrownInstitut des Sciences du Vegetal, UPR 2355, CNRSGif-Sur-IvetteFRA39 aut.40 aut.52 aut.Mickael BourgeInstitut des Sciences du Vegetal, UPR 2355, CNRSGif-Sur-IvetteFRA39 aut.40 aut.52 aut.Wolfgang GolserArizona Genomics Institute and School of Plant Sciences, University of ArizonaTucson, ArizonaUSA20 aut.21 aut.41 aut.42 aut.54 aut.XIANG SONGArizona Genomics Institute and School of Plant Sciences, University of ArizonaTucson, ArizonaUSA20 aut.21 aut.41 aut.42 aut.54 aut.Didier ClementCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Ronan RivallanCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Mathias TahiCentre National de la Recherche Agronomique (CNRA)DivoCIV45 aut.46 aut.Joseph Moroh AkazaCentre National de la Recherche Agronomique (CNRA)DivoCIV45 aut.46 aut.Bertrand PitollatCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Karina GramachoComissão Executiva de Planejamento da Lavoura Cacaueira (CEPLAC)Itabuna BahiaBRA48 aut.Angelique D HontCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Dominique BrunelINRA, UR 1279 Etude du Polymorphisme des Génomes Végétaux, CEA Institut de Génomique, Centre National de Génotypage, CP5724EvryFRA30 aut.50 aut.Diogenes InfanteCentro Nacional de Biotecnologia Agricola, Instituto de Estudios Avanzados (IDEA)CaracasVEN51 aut.Ismael KebeInstitut des Sciences du Vegetal, UPR 2355, CNRSGif-Sur-IvetteFRA39 aut.40 aut.52 aut.Pierre CostetChocolaterie VALRHONA, Tain l'HermitageFRA53 aut.Rod WingArizona Genomics Institute and School of Plant Sciences, University of ArizonaTucson, ArizonaUSA20 aut.21 aut.41 aut.42 aut.54 aut.W. Richard MccombieCold Spring Harbor LaboratoryCold Spring Harbor, New YorkUSA27 aut.28 aut.38 aut.55 aut.Emmanuel GuiderdoniCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Francis QuetierDépartement de Biologie, Université d'Evry Val d'EssonneEvryFRA57 aut.Olivier PanaudUMR 5096 CNRS-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD), Laboratoire Génome et Développement des PlantesPerpignanFRA8 aut.18 aut.19 aut.58 aut.Patrick WinckerCommissariat à l'Energie Antomique (CEA), Institut de Génomique (IG), GenoscopeEvryFRA3 aut.14 aut.59 aut.Centre National de Recherche Scientifique (CNRS), UMR 8030, CP5706EvryFRA3 aut.14 aut.59 aut.Université d'EvryEFRA3 aut.14 aut.59 aut.Stephanie BocsCentre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.11-01575732011PASCAL 11-0157573 INISTPascal:11-01575730012231061-4036Nat. genet.Nature geneticsGenomeTheobroma cacaoGénomeTheobroma cacao
We sequenced and assembled the draft genome of Theobroma cacao, an economically important tropical-fruit tree crop that is the source of chocolate. This assembly corresponds to 76% of the estimated genome size and contains almost all previously described genes, with 82% of these genes anchored on the 10 T. cacao chromosomes. Analysis of this sequence information highlighted specific expansion of some gene families during evolution, for example, flavonoid-related genes. It also provides a major source of candidate genes for T. cacao improvement. Based on the inferred paleohistory of the T. cacao genome, we propose an evolutionary scenario whereby the ten T. cacao chromosomes were shaped from an ancestor through eleven chromosome fusions.
1061-4036NGENECNat. genet.432The genome of Theobroma cacaoARGOUT (Xavier)SALSE (Jerome)AURY (Jean-Marc)GUILTINAN (Mark J.)DROC (Gaetan)GOUZY (Jerome)ALLEGRE (Mathilde)CHAPARRO (Cristian)LEGAVRE (Thierry)MAXIMOVA (Siela N.)ABROUK (Michael)MURAT (Florent)FOUET (Olivier)POULAIN (Julie)RUIZ (Manuel)ROGUET (Yolande)RODIER-GOUD (Maguy)FERNANDES BARBOSA-NETO (Jose)SABOT (Francois)KUDRNA (Dave)AMMIRAJU (Jetty Siva S.)SCHUSTER (Stephan C.)CARLSON (John E.)SALLET (Erika)SCHIEX (Thomas)DIEVART (Anne)KRAMER (Melissa)GELLEY (Laura)ZI SHIBERARD (Aurélie)VIOT (Christopher)BOCCARA (Michel)RISTERUCCI (Ange Marie)GUIGNON (Valentin)SABAU (Xavier)AXTELL (Michael J.)ZHAORONG MAYUFAN ZHANGBROWN (Spencer)BOURGE (Mickael)GOLSER (Wolfgang)XIANG SONGCLEMENT (Didier)RIVALLAN (Ronan)TAHI (Mathias)MOROH AKAZA (Joseph)PITOLLAT (Bertrand)GRAMACHO (Karina)D'HONT (Angelique)BRUNEL (Dominique)INFANTE (Diogenes)KEBE (Ismael)COSTET (Pierre)WING (Rod)MCCOMBIE (W. Richard)GUIDERDONI (Emmanuel)QUETIER (Francis)PANAUD (Olivier)WINCKER (Patrick)BOCS (Stephanie)Centre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398MontpellierFRA1 aut.5 aut.7 aut.9 aut.13 aut.15 aut.16 aut.17 aut.26 aut.31 aut.32 aut.33 aut.34 aut.35 aut.43 aut.44 aut.47 aut.49 aut.56 aut.60 aut.Institut National de la Recherche Agronomique UMR 1095Clermont-FerrandFRA2 aut.11 aut.12 aut.Commissariat à l'Energie Antomique (CEA), Institut de Génomique (IG), GenoscopeEvryFRA3 aut.14 aut.59 aut.Centre National de Recherche Scientifique (CNRS), UMR 8030, CP5706EvryFRA3 aut.14 aut.59 aut.Université d'EvryEFRA3 aut.14 aut.59 aut.Penn State University, Department of Horticulture and the Huck Institutes of the Life SciencesUniversity Park, PennsylvaniaUSA4 aut.10 aut.Penn State University, Plant Biology Graduate Program and the Huck Institutes of the Life SciencesUniversity Park, PennsylvaniaUSA4 aut.29 aut.38 aut.Institut National de la Recherche Agronomique (INRA)-CNRS Laboratoire des Interactions Plantes Micro-organismes (LIPM)Castanet TolosanFRA6 aut.24 aut.UMR 5096 CNRS-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD), Laboratoire Génome et Développement des PlantesPerpignanFRA8 aut.18 aut.19 aut.58 aut.Arizona Genomics Institute and School of Plant Sciences, University of ArizonaTucson, ArizonaUSA20 aut.21 aut.41 aut.42 aut.54 aut.Penn State University, Department of Biochemistry and Molecular BiologyUniversity Park, PennsylvaniaUSA22 aut.Penn State University, the School of Forest Resources and the Huck Institutes of the Life SciencesUniversity Park, PennsylvaniaUSA23 aut.The Department of Bioenergy Science and Technology (WCU), Chonnam National UniversityBuk-Gu, GwangjuKOR23 aut.Unité de Biométrie et d'Intelligence Artificielle (UBIA), UR875 INRACastanet TolosanFRA25 aut.Cold Spring Harbor LaboratoryCold Spring Harbor, New YorkUSA27 aut.28 aut.38 aut.55 aut.INRA, UR 1279 Etude du Polymorphisme des Génomes Végétaux, CEA Institut de Génomique, Centre National de Génotypage, CP5724EvryFRA30 aut.50 aut.Penn State University, Bioinformatics and Genomics PhD Program and Department of BiologyUniversity Park, PennsylvaniaUSA36 aut.37 aut.Institut des Sciences du Vegetal, UPR 2355, CNRSGif-Sur-IvetteFRA39 aut.40 aut.52 aut.Centre National de la Recherche Agronomique (CNRA)DivoCIV45 aut.46 aut.Comissão Executiva de Planejamento da Lavoura Cacaueira (CEPLAC)Itabuna BahiaBRA48 aut.Centro Nacional de Biotecnologia Agricola, Instituto de Estudios Avanzados (IDEA)CaracasVEN51 aut.Chocolaterie VALRHONA, Tain l'HermitageFRA53 aut.Département de Biologie, Université d'Evry Val d'EssonneEvryFRA57 aut.101-1082011ENGINIST228833540001937220100200000© 2011 INIST-CNRS. All rights reserved.48 ref.11-0157573PANature geneticsUSAWe sequenced and assembled the draft genome of Theobroma cacao, an economically important tropical-fruit tree crop that is the source of chocolate. This assembly corresponds to 76% of the estimated genome size and contains almost all previously described genes, with 82% of these genes anchored on the 10 T. cacao chromosomes. Analysis of this sequence information highlighted specific expansion of some gene families during evolution, for example, flavonoid-related genes. It also provides a major source of candidate genes for T. cacao improvement. Based on the inferred paleohistory of the T. cacao genome, we propose an evolutionary scenario whereby the ten T. cacao chromosomes were shaped from an ancestor through eleven chromosome fusions.002A07Génome01Genome01Genoma01Theobroma cacaoNS02Theobroma cacaoNS02Theobroma cacaoNS02SterculiaceaeNSSterculiaceaeNSSterculiaceaeNSDicotyledonesNSDicotyledonesNSDicotyledonesNSAngiospermaeNSAngiospermaeNSAngiospermaeNSSpermatophytaNSSpermatophytaNSSpermatophytaNS101OTOOTOPASCAL 11-0157573 INISTThe genome of Theobroma cacaoARGOUT (Xavier); SALSE (Jerome); AURY (Jean-Marc); GUILTINAN (Mark J.); DROC (Gaetan); GOUZY (Jerome); ALLEGRE (Mathilde); CHAPARRO (Cristian); LEGAVRE (Thierry); MAXIMOVA (Siela N.); ABROUK (Michael); MURAT (Florent); FOUET (Olivier); POULAIN (Julie); RUIZ (Manuel); ROGUET (Yolande); RODIER-GOUD (Maguy); FERNANDES BARBOSA-NETO (Jose); SABOT (Francois); KUDRNA (Dave); AMMIRAJU (Jetty Siva S.); SCHUSTER (Stephan C.); CARLSON (John E.); SALLET (Erika); SCHIEX (Thomas); DIEVART (Anne); KRAMER (Melissa); GELLEY (Laura); ZI SHI; BERARD (Aurélie); VIOT (Christopher); BOCCARA (Michel); RISTERUCCI (Ange Marie); GUIGNON (Valentin); SABAU (Xavier); AXTELL (Michael J.); ZHAORONG MA; YUFAN ZHANG; BROWN (Spencer); BOURGE (Mickael); GOLSER (Wolfgang); XIANG SONG; CLEMENT (Didier); RIVALLAN (Ronan); TAHI (Mathias); MOROH AKAZA (Joseph); PITOLLAT (Bertrand); GRAMACHO (Karina); D'HONT (Angelique); BRUNEL (Dominique); INFANTE (Diogenes); KEBE (Ismael); COSTET (Pierre); WING (Rod); MCCOMBIE (W. Richard); GUIDERDONI (Emmanuel); QUETIER (Francis); PANAUD (Olivier); WINCKER (Patrick); BOCS (Stephanie)Centre de cooperation Internationale en Recherche Agronomique pour le Développement (CIRAD)-Biological Systems Department-Unité Mixte de Recherche Développement et Amelioration des Plantes (UMR DAP) TA A 96/03-34398/Montpellier/France (1 aut., 5 aut., 7 aut., 9 aut., 13 aut., 15 aut., 16 aut., 17 aut., 26 aut., 31 aut., 32 aut., 33 aut., 34 aut., 35 aut., 43 aut., 44 aut., 47 aut., 49 aut., 56 aut., 60 aut.); Institut National de la Recherche Agronomique UMR 1095/Clermont-Ferrand/France (2 aut., 11 aut., 12 aut.); Commissariat à l'Energie Antomique (CEA), Institut de Génomique (IG), Genoscope/Evry/France (3 aut., 14 aut., 59 aut.); Centre National de Recherche Scientifique (CNRS), UMR 8030, CP5706/Evry/France (3 aut., 14 aut., 59 aut.); Université d'Evry/E/France (3 aut., 14 aut., 59 aut.); Penn State University, Department of Horticulture and the Huck Institutes of the Life Sciences/University Park, Pennsylvania/Etats-Unis (4 aut., 10 aut.); Penn State University, Plant Biology Graduate Program and the Huck Institutes of the Life Sciences/University Park, Pennsylvania/Etats-Unis (4 aut., 29 aut., 38 aut.); Institut National de la Recherche Agronomique (INRA)-CNRS Laboratoire des Interactions Plantes Micro-organismes (LIPM)/Castanet Tolosan/France (6 aut., 24 aut.); UMR 5096 CNRS-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD), Laboratoire Génome et Développement des Plantes/Perpignan/France (8 aut., 18 aut., 19 aut., 58 aut.); Arizona Genomics Institute and School of Plant Sciences, University of Arizona/Tucson, Arizona/Etats-Unis (20 aut., 21 aut., 41 aut., 42 aut., 54 aut.); Penn State University, Department of Biochemistry and Molecular Biology/University Park, Pennsylvania/Etats-Unis (22 aut.); Penn State University, the School of Forest Resources and the Huck Institutes of the Life Sciences/University Park, Pennsylvania/Etats-Unis (23 aut.); The Department of Bioenergy Science and Technology (WCU), Chonnam National University/Buk-Gu, Gwangju/Corée, République de (23 aut.); Unité de Biométrie et d'Intelligence Artificielle (UBIA), UR875 INRA/Castanet Tolosan/France (25 aut.); Cold Spring Harbor Laboratory/Cold Spring Harbor, New York/Etats-Unis (27 aut., 28 aut., 38 aut., 55 aut.); INRA, UR 1279 Etude du Polymorphisme des Génomes Végétaux, CEA Institut de Génomique, Centre National de Génotypage, CP5724/Evry/France (30 aut., 50 aut.); Penn State University, Bioinformatics and Genomics PhD Program and Department of Biology/University Park, Pennsylvania/Etats-Unis (36 aut., 37 aut.); Institut des Sciences du Vegetal, UPR 2355, CNRS/Gif-Sur-Ivette/France (39 aut., 40 aut., 52 aut.); Centre National de la Recherche Agronomique (CNRA)/Divo/Côte d'Ivoire (45 aut., 46 aut.); Comissão Executiva de Planejamento da Lavoura Cacaueira (CEPLAC)/Itabuna Bahia/Brésil (48 aut.); Centro Nacional de Biotecnologia Agricola, Instituto de Estudios Avanzados (IDEA)/Caracas/Vénézuela (51 aut.); Chocolaterie VALRHONA, Tain l'Hermitage/France (53 aut.); Département de Biologie, Université d'Evry Val d'Essonne/Evry/France (57 aut.)
Publication en série; Niveau analytique
Nature genetics; ISSN 1061-4036; Coden NGENEC; Etats-Unis; Da. 2011; Vol. 43; No. 2; Pp. 101-108; Bibl. 48 ref.AnglaisWe sequenced and assembled the draft genome of Theobroma cacao, an economically important tropical-fruit tree crop that is the source of chocolate. This assembly corresponds to 76% of the estimated genome size and contains almost all previously described genes, with 82% of these genes anchored on the 10 T. cacao chromosomes. Analysis of this sequence information highlighted specific expansion of some gene families during evolution, for example, flavonoid-related genes. It also provides a major source of candidate genes for T. cacao improvement. Based on the inferred paleohistory of the T. cacao genome, we propose an evolutionary scenario whereby the ten T. cacao chromosomes were shaped from an ancestor through eleven chromosome fusions.002A07Génome; Theobroma cacaoSterculiaceae; Dicotyledones; Angiospermae; SpermatophytaGenome; Theobroma cacaoSterculiaceae; Dicotyledones; Angiospermae; SpermatophytaGenoma; Theobroma cacaoINIST-22883.35400019372201002011-0157573 001678 Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantationA. B. M. MadureiraEurocord Office, Hôpital Saint Louis, Assistance Publique des Hôpitaux de ParisParisFRA1 aut.4 aut.14 aut.16 aut.M. EapenCenter for International Blood and Marrow Transplant Research, Medical College of WisconsinMilwaukee, WIUSA2 aut.5 aut.F. LocatelliIRCCS, Ospedale Bambino GesuRomeITA3 aut.University of Pavia, PaviaLombardyITA3 aut.P. TeiraEurocord Office, Hôpital Saint Louis, Assistance Publique des Hôpitaux de ParisParisFRA1 aut.4 aut.14 aut.16 aut.M.-J. ZhangCenter for International Blood and Marrow Transplant Research, Medical College of WisconsinMilwaukee, WIUSA2 aut.5 aut.S. M. DaviesCincinnati Children's Hospital Medical CenterCincinnati, OHUSA6 aut.A. PicardiDivisione di Onco-Ematologica e Trapianto, Università di Rome Tor VergataRomeITA7 aut.A. WoolfreyFred Hutchinson Cancer Research CenterSeattle, WAUSA8 aut.K.-W. ChanTexas Transplant InstituteSan Antonio, TXUSA9 aut.G. SocieBone Marrow Transplantation Unit, Hôpital Saint LouisParisFRA10 aut.A. VoraHaematology Department, Sheffield Children's HospitalSheffieldGBR11 aut.Y. BertrandHôpital DebrousseLyonFRA12 aut.C. M. Sales-BonfimDepartment of Hematology, University Federal de ParanaCuritibaBRA13 aut.E. GluckmanEurocord Office, Hôpital Saint Louis, Assistance Publique des Hôpitaux de ParisParisFRA1 aut.4 aut.14 aut.16 aut.C. NiemeyerDepartment of Hematology and Oncology, Universitaets-KinderklinikFreiburgDEU15 aut.V. RochaEurocord Office, Hôpital Saint Louis, Assistance Publique des Hôpitaux de ParisParisFRA1 aut.4 aut.14 aut.16 aut.11-01586072011PASCAL 11-0158607 INISTPascal:11-01586070012220887-6924LeukemiaLeukemiaBlood cellChildChromosome C7EpidemiologyHematologyHematopoietic cellHomograftMonosomyMyelodysplastic syndromePrognosisRisk analysisRisk factorStem cellUmbilical cordUnrelated donorSyndrome myélodysplasiqueAnalyse risqueFacteur risqueEpidémiologiePronosticHomogreffeEnfantDonneur non apparentéCellule soucheCellule hématopoïétiqueCordon ombilicalCellule sanguineMonosomieChromosome C7HématologieEnfance
We describe 70 children with myelodysplastic syndrome (MDS) (refractory cytopenia (n= 31) and refractory anemia with excess blasts (n=30) or blasts in transformation (n=9)) who received umbilical cord blood (UCB) transplantation with a single UCB unit and a myeloablative conditioning regimen. Approximately 20% of children had secondary MDS. Median age at transplantation was 7 years and the median follow-up was 3 years. The day-60 probability of neutrophil recovery was 76%; recovery was faster after transplantation of matched or 1-locus mismatched UCB, irradiation-containing conditioning regimen, cell dose >6 × 107/kg and monosomy 7. Risks of treatment failure (recurrent disease or death) were lower in patients with monosomy 7 and transplantations after 2001. The 3-year disease-free survival (DFS) was 50% for transplantations after 2001 compared with 27% for the earlier period (P=0.018). Transplantations after 2001 occurred within 6 months after diagnosis and used UCB units with higher cell dose. DFS was highest in patients with monosomy 7 (61%) compared with other karyotypes (30%), P=0.017. These data suggest that transplantation of mismatched UCB graft is an acceptable alternative for children without a matched sibling or suitably matched unrelated adult donor.
0887-6924LEUKEDLeukemia253Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantationMADUREIRA (A. B. M.)EAPEN (M.)LOCATELLI (F.)TEIRA (P.)ZHANG (M.-J.)DAVIES (S. M.)PICARDI (A.)WOOLFREY (A.)CHAN (K.-W.)SOCIE (G.)VORA (A.)BERTRAND (Y.)SALES-BONFIM (C. M.)GLUCKMAN (E.)NIEMEYER (C.)ROCHA (V.)Eurocord Office, Hôpital Saint Louis, Assistance Publique des Hôpitaux de ParisParisFRA1 aut.4 aut.14 aut.16 aut.Center for International Blood and Marrow Transplant Research, Medical College of WisconsinMilwaukee, WIUSA2 aut.5 aut.IRCCS, Ospedale Bambino GesuRomeITA3 aut.University of Pavia, PaviaLombardyITA3 aut.Cincinnati Children's Hospital Medical CenterCincinnati, OHUSA6 aut.Divisione di Onco-Ematologica e Trapianto, Università di Rome Tor VergataRomeITA7 aut.Fred Hutchinson Cancer Research CenterSeattle, WAUSA8 aut.Texas Transplant InstituteSan Antonio, TXUSA9 aut.Bone Marrow Transplantation Unit, Hôpital Saint LouisParisFRA10 aut.Haematology Department, Sheffield Children's HospitalSheffieldGBR11 aut.Hôpital DebrousseLyonFRA12 aut.Department of Hematology, University Federal de ParanaCuritibaBRA13 aut.Department of Hematology and Oncology, Universitaets-KinderklinikFreiburgDEU15 aut.Eurocord-European Blood and Marrow Transplant Group, Center of International Blood and Marrow Transplant Registry and European Working Group on childhood MDSINC449-4542011ENGINIST211293540001944403400700000© 2011 INIST-CNRS. All rights reserved.37 ref.11-0158607PALeukemiaGBRWe describe 70 children with myelodysplastic syndrome (MDS) (refractory cytopenia (n= 31) and refractory anemia with excess blasts (n=30) or blasts in transformation (n=9)) who received umbilical cord blood (UCB) transplantation with a single UCB unit and a myeloablative conditioning regimen. Approximately 20% of children had secondary MDS. Median age at transplantation was 7 years and the median follow-up was 3 years. The day-60 probability of neutrophil recovery was 76%; recovery was faster after transplantation of matched or 1-locus mismatched UCB, irradiation-containing conditioning regimen, cell dose >6 × 107/kg and monosomy 7. Risks of treatment failure (recurrent disease or death) were lower in patients with monosomy 7 and transplantations after 2001. The 3-year disease-free survival (DFS) was 50% for transplantations after 2001 compared with 27% for the earlier period (P=0.018). Transplantations after 2001 occurred within 6 months after diagnosis and used UCB units with higher cell dose. DFS was highest in patients with monosomy 7 (61%) compared with other karyotypes (30%), P=0.017. These data suggest that transplantation of mismatched UCB graft is an acceptable alternative for children without a matched sibling or suitably matched unrelated adult donor.002B19B002B23BSyndrome myélodysplasique01Myelodysplastic syndrome01Mielodisplastico síndrome01Analyse risque02Risk analysis02Análisis riesgo02Facteur risque03Risk factor03Factor riesgo03Epidémiologie05Epidemiology05Epidemiología05Pronostic06Prognosis06Pronóstico06Homogreffe07Homograft07Homoinjerto07Enfant08Child08Niño08Donneur non apparenté09Unrelated donor09Donador no relacionado09Cellule souche11Stem cell11Célula primitiva11Cellule hématopoïétique12Hematopoietic cell12Célula hematopoyética12Cordon ombilical17Umbilical cord17Cordón umbilical17Cellule sanguine18Blood cell18Célula sanguínea18Monosomie19Monosomy19Monosomía19Chromosome C720Chromosome C720Cromosoma C720Hématologie21Hematology21Hematología21EnfanceINC86HommeHumanHombreAneuploïdieAneuploidyAneuploidíaAberration chromosomiqueChromosomal aberrationAberración cromosómicaHémopathie maligneNM37Malignant hemopathyNM37Hemopatía malignaNM37CancerNMCancerNMCáncerNMGreffe38Graft38Injerto38101OTOOTOPASCAL 11-0158607 INISTAnalysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantationMADUREIRA (A. B. M.); EAPEN (M.); LOCATELLI (F.); TEIRA (P.); ZHANG (M.-J.); DAVIES (S. M.); PICARDI (A.); WOOLFREY (A.); CHAN (K.-W.); SOCIE (G.); VORA (A.); BERTRAND (Y.); SALES-BONFIM (C. M.); GLUCKMAN (E.); NIEMEYER (C.); ROCHA (V.)Eurocord Office, Hôpital Saint Louis, Assistance Publique des Hôpitaux de Paris/Paris/France (1 aut., 4 aut., 14 aut., 16 aut.); Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin/Milwaukee, WI/Etats-Unis (2 aut., 5 aut.); IRCCS, Ospedale Bambino Gesu/Rome/Italie (3 aut.); University of Pavia, Pavia/Lombardy/Italie (3 aut.); Cincinnati Children's Hospital Medical Center/Cincinnati, OH/Etats-Unis (6 aut.); Divisione di Onco-Ematologica e Trapianto, Università di Rome Tor Vergata/Rome/Italie (7 aut.); Fred Hutchinson Cancer Research Center/Seattle, WA/Etats-Unis (8 aut.); Texas Transplant Institute/San Antonio, TX/Etats-Unis (9 aut.); Bone Marrow Transplantation Unit, Hôpital Saint Louis/Paris/France (10 aut.); Haematology Department, Sheffield Children's Hospital/Sheffield/Royaume-Uni (11 aut.); Hôpital Debrousse/Lyon/France (12 aut.); Department of Hematology, University Federal de Parana/Curitiba/Brésil (13 aut.); Department of Hematology and Oncology, Universitaets-Kinderklinik/Freiburg/Allemagne (15 aut.)
Publication en série; Niveau analytique
Leukemia; ISSN 0887-6924; Coden LEUKED; Royaume-Uni; Da. 2011; Vol. 25; No. 3; Pp. 449-454; Bibl. 37 ref.AnglaisWe describe 70 children with myelodysplastic syndrome (MDS) (refractory cytopenia (n= 31) and refractory anemia with excess blasts (n=30) or blasts in transformation (n=9)) who received umbilical cord blood (UCB) transplantation with a single UCB unit and a myeloablative conditioning regimen. Approximately 20% of children had secondary MDS. Median age at transplantation was 7 years and the median follow-up was 3 years. The day-60 probability of neutrophil recovery was 76%; recovery was faster after transplantation of matched or 1-locus mismatched UCB, irradiation-containing conditioning regimen, cell dose >6 × 107/kg and monosomy 7. Risks of treatment failure (recurrent disease or death) were lower in patients with monosomy 7 and transplantations after 2001. The 3-year disease-free survival (DFS) was 50% for transplantations after 2001 compared with 27% for the earlier period (P=0.018). Transplantations after 2001 occurred within 6 months after diagnosis and used UCB units with higher cell dose. DFS was highest in patients with monosomy 7 (61%) compared with other karyotypes (30%), P=0.017. These data suggest that transplantation of mismatched UCB graft is an acceptable alternative for children without a matched sibling or suitably matched unrelated adult donor.002B19B; 002B23BSyndrome myélodysplasique; Analyse risque; Facteur risque; Epidémiologie; Pronostic; Homogreffe; Enfant; Donneur non apparenté; Cellule souche; Cellule hématopoïétique; Cordon ombilical; Cellule sanguine; Monosomie; Chromosome C7; Hématologie; EnfanceHomme; Aneuploïdie; Aberration chromosomique; Hémopathie maligne; Cancer; GreffeMyelodysplastic syndrome; Risk analysis; Risk factor; Epidemiology; Prognosis; Homograft; Child; Unrelated donor; Stem cell; Hematopoietic cell; Umbilical cord; Blood cell; Monosomy; Chromosome C7; HematologyHuman; Aneuploidy; Chromosomal aberration; Malignant hemopathy; Cancer; GraftMielodisplastico síndrome; Análisis riesgo; Factor riesgo; Epidemiología; Pronóstico; Homoinjerto; Niño; Donador no relacionado; Célula primitiva; Célula hematopoyética; Cordón umbilical; Célula sanguínea; Monosomía; Cromosoma C7; HematologíaINIST-21129.35400019444034007011-0158607 001679 A note on Gao's algorithm for polynomial factorizationCarlos HoppenInstituto de Matemática, Universidade Federal do Rio Grande do Sul - Avenida Bento Gonçalves, 950091509-900 Porto Alegre-RSBRA1 aut.3 aut.Virginia M. RodriguesDepartamento de Matemática, Pontifícia Universidade Católica - Avenida Ipiranga, 668191530-000 Porto Alegre-RSBRA2 aut.Vilmar TrevisanInstituto de Matemática, Universidade Federal do Rio Grande do Sul - Avenida Bento Gonçalves, 950091509-900 Porto Alegre-RSBRA1 aut.3 aut.11-01586532011PASCAL 11-0158653 INISTPascal:11-01586530012210304-3975Theor. comput. sci.Theoretical computer scienceComputer theoryDifferential equationFinite fieldPartial differential equationPolynomialVector subspaceInformatique théoriquePolynômeEquation dérivée partielleEquation différentielleCorps finiAlgorithme polynomialFactorisation polynomiale68Wxx65Mxx65M9965Nxx65N9935XXEspace polynomial34XXTermeChamp fini11TxxSous espace vectoriel
Shuhong Gao (2003)[6] has proposed an efficient algorithm to factor a bivariate polynomial f over a field F. This algorithm is based on a simple partial differential equation and depends on a crucial fact: the dimension of the polynomial solution space G associated with this differential equation is equal to the number r of absolutely irreducible factors of f. However, this holds only when the characteristic of F is either zero or sufficiently large in terms of the degree of f. In this paper we characterize a vector subspace of G for which the dimension is r, regardless of the characteristic of F, and the properties of Gao's construction hold. Moreover, we identify a second vector subspace of G that leads to an analogous theory for the rational factorization of f.
0304-3975TCSCDITheor. comput. sci.41216A note on Gao's algorithm for polynomial factorizationSymbolic and Numerical AlgorithmsHOPPEN (Carlos)RODRIGUES (Virginia M.)TREVISAN (Vilmar)KOTSIREAS (Ilias S.)ed.MOURRAIN (Bernard)ed.PAN (Victor Y.)ed.Instituto de Matemática, Universidade Federal do Rio Grande do Sul - Avenida Bento Gonçalves, 950091509-900 Porto Alegre-RSBRA1 aut.3 aut.Departamento de Matemática, Pontifícia Universidade Católica - Avenida Ipiranga, 668191530-000 Porto Alegre-RSBRA2 aut.Wilfrid Laurier University, 75 University Avenue WestWaterloo, Ontario, N2L 3C5CAN1 aut.EPI GALAAD, INRIA, Mediterranée 2004 route des Lucioles, B. P. 9306902 Sophia AntipolisFRA2 aut.Department of Mathematics and Computer Science, Lehman College of the City University of New YorkBronx, NY 10468USA3 aut.1508-15222011ENGINIST172433540001946178000600000© 2011 INIST-CNRS. All rights reserved.24 ref.11-0158653PATheoretical computer scienceGBRShuhong Gao (2003)[6] has proposed an efficient algorithm to factor a bivariate polynomial f over a field F. This algorithm is based on a simple partial differential equation and depends on a crucial fact: the dimension of the polynomial solution space G associated with this differential equation is equal to the number r of absolutely irreducible factors of f. However, this holds only when the characteristic of F is either zero or sufficiently large in terms of the degree of f. In this paper we characterize a vector subspace of G for which the dimension is r, regardless of the characteristic of F, and the properties of Gao's construction hold. Moreover, we identify a second vector subspace of G that leads to an analogous theory for the rational factorization of f.001D02A08001D02A05001A02I01J001A02I01KInformatique théorique01Computer theory01Informática teórica01Polynôme17Polynomial17Polinomio17Equation dérivée partielle18Partial differential equation18Ecuación derivada parcial18Equation différentielle19Differential equation19Ecuación diferencial19Corps fini20Finite field20Campo finito20Algorithme polynomialINC70Factorisation polynomialeINC7168WxxINC7265MxxINC7365M99INC7465NxxINC7565N99INC7635XXINC77Espace polynomialINC7834XXINC79TermeINC80Champ finiINC8111TxxINC82Sous espace vectorielCD96Vector subspaceCD96101OTOOTOPASCAL 11-0158653 INISTA note on Gao's algorithm for polynomial factorizationHOPPEN (Carlos); RODRIGUES (Virginia M.); TREVISAN (Vilmar); KOTSIREAS (Ilias S.); MOURRAIN (Bernard); PAN (Victor Y.)Instituto de Matemática, Universidade Federal do Rio Grande do Sul - Avenida Bento Gonçalves, 9500/91509-900 Porto Alegre-RS/Brésil (1 aut., 3 aut.); Departamento de Matemática, Pontifícia Universidade Católica - Avenida Ipiranga, 6681/91530-000 Porto Alegre-RS/Brésil (2 aut.); Wilfrid Laurier University, 75 University Avenue West/Waterloo, Ontario, N2L 3C5/Canada (1 aut.); EPI GALAAD, INRIA, Mediterranée 2004 route des Lucioles, B. P. 93/06902 Sophia Antipolis/France (2 aut.); Department of Mathematics and Computer Science, Lehman College of the City University of New York/Bronx, NY 10468/Etats-Unis (3 aut.)
Publication en série; Niveau analytique
Theoretical computer science; ISSN 0304-3975; Coden TCSCDI; Royaume-Uni; Da. 2011; Vol. 412; No. 16; Pp. 1508-1522; Bibl. 24 ref.AnglaisShuhong Gao (2003)[6] has proposed an efficient algorithm to factor a bivariate polynomial f over a field F. This algorithm is based on a simple partial differential equation and depends on a crucial fact: the dimension of the polynomial solution space G associated with this differential equation is equal to the number r of absolutely irreducible factors of f. However, this holds only when the characteristic of F is either zero or sufficiently large in terms of the degree of f. In this paper we characterize a vector subspace of G for which the dimension is r, regardless of the characteristic of F, and the properties of Gao's construction hold. Moreover, we identify a second vector subspace of G that leads to an analogous theory for the rational factorization of f.001D02A08; 001D02A05; 001A02I01J; 001A02I01KInformatique théorique; Polynôme; Equation dérivée partielle; Equation différentielle; Corps fini; Algorithme polynomial; Factorisation polynomiale; 68Wxx; 65Mxx; 65M99; 65Nxx; 65N99; 35XX; Espace polynomial; 34XX; Terme; Champ fini; 11Txx; Sous espace vectorielComputer theory; Polynomial; Partial differential equation; Differential equation; Finite field; Vector subspaceInformática teórica; Polinomio; Ecuación derivada parcial; Ecuación diferencial; Campo finitoINIST-17243.35400019461780006011-0158653 001680 Potential utility of empirical tuberculosis treatment for HIV-infected patients with advanced immunodeficiency in high TB-HIV burden settingsS. D. LawnDepartment of Infectious and Tropical Diseases, London School of Hygiene & Tropical MedicineLondonGBR1 aut.2 aut.7 aut.9 aut.Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape TownCape TownZAF1 aut.H. AylesDepartment of Infectious and Tropical Diseases, London School of Hygiene & Tropical MedicineLondonGBR1 aut.2 aut.7 aut.9 aut.Zambia AIDS Related Tuberculosis Project, University of Zambia Ridgeway CampusLusakaZMB2 aut.S. EgwagaNational Tuberculosis Programme, Dar Es SalaamTZA3 aut.B. WilliamsSouth African Centre for Epidemiological Modelling and Analysis (SACEMA)StellenboschZAF4 aut.Y. D. MukadiFamily Health InternationalWashington, DCUSA5 aut.E. D. Santos FilhoGrupo Pela VIDDA-Rio de Janeiro, Parceria Brasileira Contra a Tuberculose (Stop TB Brazil), Rio de JaneiroRio de JaneiroBRA6 aut.P. Godfrey-FaussettDepartment of Infectious and Tropical Diseases, London School of Hygiene & Tropical MedicineLondonGBR1 aut.2 aut.7 aut.9 aut.R. M. GranichDepartment of HIV/AIDS, World Health OrganizationGenevaCHE8 aut.A. D. HarriesDepartment of Infectious and Tropical Diseases, London School of Hygiene & Tropical MedicineLondonGBR1 aut.2 aut.7 aut.9 aut.International Union Against Tuberculosis and Lung DiseaseParisFRA9 aut.11-01589912011PASCAL 11-0158991 INISTPascal:11-01589910012201027-3719Int. j. tuberc. lung dis.International journal of tuberculosis and lung diseaseAIDSAfricaHighHuman immunodeficiency virusImmune deficiencyMortalityPneumologyPrognosisRespiratory diseaseSettingTreatmentTuberculosisTuberculoseSIDAImmunodéficitPathologie de l'appareil respiratoireTraitementHautVirus immunodéficience humainePriseAfriquePronosticMortalitéPneumologie
The human immunodeficiency virus (HIV) and HIV-associated tuberculosis (TB-HIV) epidemics remain uncontrolled in many resource-limited regions, especially in sub-Saharan Africa. The scale of these epidemics requires the consideration of innovative bold interventions and 'out-of-the-box' thinking. To this end, a symposium entitled 'Controversies in HIV' was held at the 40th Union World Conference on Lung Health in Cancun, Mexico, in December 2009. The first topic debated, entitled 'Annual HIV testing and immediate start of antiretroviral therapy for all HIV-infected persons', received much attention at international conferences and in the literature in 2009. The second topic forms the subject of this article. The rationale for the use of empirical TB treatment is premised on the hypothesis that in settings worst affected by the TB-HIV epidemic, a subset of HIV-infected patients have such a high risk of undiagnosed TB and of associated mortality that their prognosis may be improved by immediate initiation of empirical TB treatment used in conjunction with antiretroviral therapy. In addition to morbidity and mortality reduction, additional benefits may include prevention of nosocomial TB transmission and TB preventive effect. Potential adverse consequences, however, may include failure to consider other non-TB diagnoses, drug co-toxicity, compromised treatment adherence, and logistical and resource challenges. There may also be general reluctance among national TB programmes to endorse such a strategy. Following fruitful debate, the conclusion that this strategy should be carefully evaluated in randomised controlled trials was strongly supported. This paper provides an in-depth consideration of this proposed intervention.
1027-3719Int. j. tuberc. lung dis.153Potential utility of empirical tuberculosis treatment for HIV-infected patients with advanced immunodeficiency in high TB-HIV burden settingsLAWN (S. D.)AYLES (H.)EGWAGA (S.)WILLIAMS (B.)MUKADI (Y. D.)SANTOS FILHO (E. D.)GODFREY-FAUSSETT (P.)GRANICH (R. M.)HARRIES (A. D.)Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical MedicineLondonGBR1 aut.2 aut.7 aut.9 aut.Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape TownCape TownZAF1 aut.Zambia AIDS Related Tuberculosis Project, University of Zambia Ridgeway CampusLusakaZMB2 aut.National Tuberculosis Programme, Dar Es SalaamTZA3 aut.South African Centre for Epidemiological Modelling and Analysis (SACEMA)StellenboschZAF4 aut.Family Health InternationalWashington, DCUSA5 aut.Grupo Pela VIDDA-Rio de Janeiro, Parceria Brasileira Contra a Tuberculose (Stop TB Brazil), Rio de JaneiroRio de JaneiroBRA6 aut.Department of HIV/AIDS, World Health OrganizationGenevaCHE8 aut.International Union Against Tuberculosis and Lung DiseaseParisFRA9 aut.287-2952011ENGINIST264503540001907574700200000© 2011 INIST-CNRS. All rights reserved.63 ref.11-0158991PAInternational journal of tuberculosis and lung diseaseFRAThe human immunodeficiency virus (HIV) and HIV-associated tuberculosis (TB-HIV) epidemics remain uncontrolled in many resource-limited regions, especially in sub-Saharan Africa. The scale of these epidemics requires the consideration of innovative bold interventions and 'out-of-the-box' thinking. To this end, a symposium entitled 'Controversies in HIV' was held at the 40th Union World Conference on Lung Health in Cancun, Mexico, in December 2009. The first topic debated, entitled 'Annual HIV testing and immediate start of antiretroviral therapy for all HIV-infected persons', received much attention at international conferences and in the literature in 2009. The second topic forms the subject of this article. The rationale for the use of empirical TB treatment is premised on the hypothesis that in settings worst affected by the TB-HIV epidemic, a subset of HIV-infected patients have such a high risk of undiagnosed TB and of associated mortality that their prognosis may be improved by immediate initiation of empirical TB treatment used in conjunction with antiretroviral therapy. In addition to morbidity and mortality reduction, additional benefits may include prevention of nosocomial TB transmission and TB preventive effect. Potential adverse consequences, however, may include failure to consider other non-TB diagnoses, drug co-toxicity, compromised treatment adherence, and logistical and resource challenges. There may also be general reluctance among national TB programmes to endorse such a strategy. Following fruitful debate, the conclusion that this strategy should be carefully evaluated in randomised controlled trials was strongly supported. This paper provides an in-depth consideration of this proposed intervention.002B11D002B05B02O002B05C02D002B06D01Tuberculose01Tuberculosis01Tuberculosis01SIDA02AIDS02SIDA02Immunodéficit03Immune deficiency03Inmunodeficiencia03Pathologie de l'appareil respiratoire04Respiratory disease04Aparato respiratorio patología04Traitement09Treatment09Tratamiento09Haut10High10Alto10Virus immunodéficience humaineNW11Human immunodeficiency virusNW11Human immunodeficiency virusNW11Prise12Setting12Toma12AfriqueNG13AfricaNG13AfricaNG13Pronostic14Prognosis14Pronóstico14Mortalité15Mortality15Mortalidad15Pneumologie16Pneumology16Neumología16MycobactérioseMycobacterial infectionMicobacteriosisBactérioseBacteriosisBacteriosisInfectionInfectionInfecciónViroseViral diseaseVirosisLentivirusNWLentivirusNWLentivirusNWRetroviridaeNWRetroviridaeNWRetroviridaeNWVirusNWVirusNWVirusNWImmunopathologie38Immunopathology38Inmunopatología38101OTOOTOPASCAL 11-0158991 INISTPotential utility of empirical tuberculosis treatment for HIV-infected patients with advanced immunodeficiency in high TB-HIV burden settingsLAWN (S. D.); AYLES (H.); EGWAGA (S.); WILLIAMS (B.); MUKADI (Y. D.); SANTOS FILHO (E. D.); GODFREY-FAUSSETT (P.); GRANICH (R. M.); HARRIES (A. D.)Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine/London/Royaume-Uni (1 aut., 2 aut., 7 aut., 9 aut.); Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town/Cape Town/Afrique du Sud (1 aut.); Zambia AIDS Related Tuberculosis Project, University of Zambia Ridgeway Campus/Lusaka/Zambie (2 aut.); National Tuberculosis Programme, Dar Es Salaam/Tanzanie (3 aut.); South African Centre for Epidemiological Modelling and Analysis (SACEMA)/Stellenbosch/Afrique du Sud (4 aut.); Family Health International/Washington, DC/Etats-Unis (5 aut.); Grupo Pela VIDDA-Rio de Janeiro, Parceria Brasileira Contra a Tuberculose (Stop TB Brazil), Rio de Janeiro/Rio de Janeiro/Brésil (6 aut.); Department of HIV/AIDS, World Health Organization/Geneva/Suisse (8 aut.); International Union Against Tuberculosis and Lung Disease/Paris/France (9 aut.)
Publication en série; Niveau analytique
International journal of tuberculosis and lung disease; ISSN 1027-3719; France; Da. 2011; Vol. 15; No. 3; Pp. 287-295; Bibl. 63 ref.AnglaisThe human immunodeficiency virus (HIV) and HIV-associated tuberculosis (TB-HIV) epidemics remain uncontrolled in many resource-limited regions, especially in sub-Saharan Africa. The scale of these epidemics requires the consideration of innovative bold interventions and 'out-of-the-box' thinking. To this end, a symposium entitled 'Controversies in HIV' was held at the 40th Union World Conference on Lung Health in Cancun, Mexico, in December 2009. The first topic debated, entitled 'Annual HIV testing and immediate start of antiretroviral therapy for all HIV-infected persons', received much attention at international conferences and in the literature in 2009. The second topic forms the subject of this article. The rationale for the use of empirical TB treatment is premised on the hypothesis that in settings worst affected by the TB-HIV epidemic, a subset of HIV-infected patients have such a high risk of undiagnosed TB and of associated mortality that their prognosis may be improved by immediate initiation of empirical TB treatment used in conjunction with antiretroviral therapy. In addition to morbidity and mortality reduction, additional benefits may include prevention of nosocomial TB transmission and TB preventive effect. Potential adverse consequences, however, may include failure to consider other non-TB diagnoses, drug co-toxicity, compromised treatment adherence, and logistical and resource challenges. There may also be general reluctance among national TB programmes to endorse such a strategy. Following fruitful debate, the conclusion that this strategy should be carefully evaluated in randomised controlled trials was strongly supported. This paper provides an in-depth consideration of this proposed intervention.002B11D; 002B05B02O; 002B05C02D; 002B06D01Tuberculose; SIDA; Immunodéficit; Pathologie de l'appareil respiratoire; Traitement; Haut; Virus immunodéficience humaine; Prise; Afrique; Pronostic; Mortalité; PneumologieMycobactériose; Bactériose; Infection; Virose; Lentivirus; Retroviridae; Virus; ImmunopathologieTuberculosis; AIDS; Immune deficiency; Respiratory disease; Treatment; High; Human immunodeficiency virus; Setting; Africa; Prognosis; Mortality; PneumologyMycobacterial infection; Bacteriosis; Infection; Viral disease; Lentivirus; Retroviridae; Virus; ImmunopathologyTuberculosis; SIDA; Inmunodeficiencia; Aparato respiratorio patología; Tratamiento; Alto; Human immunodeficiency virus; Toma; Africa; Pronóstico; Mortalidad; NeumologíaINIST-26450.35400019075747002011-0158991 001681 Equilibrium of Cu(II) and Ni(II) biosorption by marine alga Sargassum filipendula in a dynamic system: Competitiveness and selectivityS. J. KleinubingSchool of Chemical Engineering, Campinas State University, UNICAMP, Cidade Universitária Zeferino Vaz, Caixa Postal 6066-CEP 13081-970 CampinasSPBRA1 aut.3 aut.Ecale de Mines d'Alès, Laboratoire Génie de l'Environnement Industriel, 6 avenue de Clavieres30319 AlèsFRA1 aut.4 aut.E. A. Da SilvaSchool of Chemical Engineering, West Paraná State University, UNIOESTE, Rua da Faculdade 2550, Jardim La SalleCEP 85903-000 ToledoBRA2 aut.M. G. C. Da SilvaSchool of Chemical Engineering, Campinas State University, UNICAMP, Cidade Universitária Zeferino Vaz, Caixa Postal 6066-CEP 13081-970 CampinasSPBRA1 aut.3 aut.E. GuibalEcale de Mines d'Alès, Laboratoire Génie de l'Environnement Industriel, 6 avenue de Clavieres30319 AlèsFRA1 aut.4 aut.11-01598262011PASCAL 11-0159826 INISTPascal:11-01598260012190960-8524Bioresour. technol.Bioresource technologyAdsorption isothermBiosorptionBreakthrough curveCompetitivenessCopperDynamic characteristicMarine algaNickelSargassumSelectivitySorptionBiosorptionCaractéristique dynamiqueCompétitivitéSélectivitéCourbe ruptureSorptionIsotherme adsorptionSargassumNickelCuivreAlgue marine
The study focuses on the equilibrium of dynamic biosorption in single and binary systems containing Cu(II) and Ni(II) ions using Sargassum filipendula (a marine alga). The experiments were performed in fixed-bed columns with both single-component and bi-component metal solutions (using different molar concentrations). Experimental data were fitted with different equilibrium models such as Langmuir, Langmuir with inhibition, Jain and Snowyink and Langmuir-Freundlich equations. The biosorption of pure metal ions in solution presented adequate capacities both for Cu(II) and Ni(II). In binary solutions the preferential sorption of Cu(II) over Ni(II) was demonstrated by the displacement of Ni(II) (marked overshoot on the breakthrough curves).
0960-8524Bioresour. technol.1027Equilibrium of Cu(II) and Ni(II) biosorption by marine alga Sargassum filipendula in a dynamic system: Competitiveness and selectivityKLEINUBING (S. J.)DA SILVA (E. A.)DA SILVA (M. G. C.)GUIBAL (E.)School of Chemical Engineering, Campinas State University, UNICAMP, Cidade Universitária Zeferino Vaz, Caixa Postal 6066-CEP 13081-970 CampinasSPBRA1 aut.3 aut.Ecale de Mines d'Alès, Laboratoire Génie de l'Environnement Industriel, 6 avenue de Clavieres30319 AlèsFRA1 aut.4 aut.School of Chemical Engineering, West Paraná State University, UNIOESTE, Rua da Faculdade 2550, Jardim La SalleCEP 85903-000 ToledoBRA2 aut.4610-46172011ENGINIST187693540001927915800300000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0159826PABioresource technologyGBRThe study focuses on the equilibrium of dynamic biosorption in single and binary systems containing Cu(II) and Ni(II) ions using Sargassum filipendula (a marine alga). The experiments were performed in fixed-bed columns with both single-component and bi-component metal solutions (using different molar concentrations). Experimental data were fitted with different equilibrium models such as Langmuir, Langmuir with inhibition, Jain and Snowyink and Langmuir-Freundlich equations. The biosorption of pure metal ions in solution presented adequate capacities both for Cu(II) and Ni(II). In binary solutions the preferential sorption of Cu(II) over Ni(II) was demonstrated by the displacement of Ni(II) (marked overshoot on the breakthrough curves).002A31215Biosorption01Biosorption01Biosorción01Caractéristique dynamique02Dynamic characteristic02Característica dinámica02Compétitivité03Competitiveness03Competitividad03Sélectivité04Selectivity04Selectividad04Courbe rupture05Breakthrough curve05Curva ruptura05Sorption06Sorption06Sorción06Isotherme adsorption07Adsorption isotherm07Isotermo adsorción07SargassumNS10SargassumNS10SargassumNS10NickelNCFX15NickelNCFX15NiquelNCFX15CuivreNC16CopperNC16CobreNC16Algue marineCD96Marine algaCD96Alga marinaCD96PhaeophyceaeNSPhaeophyceaeNSPhaeophyceaeNSHeterokontophytaNSHeterokontophytaNSHeterokontophytaNSAlgaeNSAlgaeNSAlgaeNS101OTOOTOPASCAL 11-0159826 INISTEquilibrium of Cu(II) and Ni(II) biosorption by marine alga Sargassum filipendula in a dynamic system: Competitiveness and selectivityKLEINUBING (S. J.); DA SILVA (E. A.); DA SILVA (M. G. C.); GUIBAL (E.)School of Chemical Engineering, Campinas State University, UNICAMP, Cidade Universitária Zeferino Vaz, Caixa Postal 6066-CEP 13081-970 Campinas/SP/Brésil (1 aut., 3 aut.); Ecale de Mines d'Alès, Laboratoire Génie de l'Environnement Industriel, 6 avenue de Clavieres/30319 Alès/France (1 aut., 4 aut.); School of Chemical Engineering, West Paraná State University, UNIOESTE, Rua da Faculdade 2550, Jardim La Salle/CEP 85903-000 Toledo/Brésil (2 aut.)
Publication en série; Niveau analytique
Bioresource technology; ISSN 0960-8524; Royaume-Uni; Da. 2011; Vol. 102; No. 7; Pp. 4610-4617; Bibl. 3/4 p.AnglaisThe study focuses on the equilibrium of dynamic biosorption in single and binary systems containing Cu(II) and Ni(II) ions using Sargassum filipendula (a marine alga). The experiments were performed in fixed-bed columns with both single-component and bi-component metal solutions (using different molar concentrations). Experimental data were fitted with different equilibrium models such as Langmuir, Langmuir with inhibition, Jain and Snowyink and Langmuir-Freundlich equations. The biosorption of pure metal ions in solution presented adequate capacities both for Cu(II) and Ni(II). In binary solutions the preferential sorption of Cu(II) over Ni(II) was demonstrated by the displacement of Ni(II) (marked overshoot on the breakthrough curves).002A31; 215Biosorption; Caractéristique dynamique; Compétitivité; Sélectivité; Courbe rupture; Sorption; Isotherme adsorption; Sargassum; Nickel; Cuivre; Algue marinePhaeophyceae; Heterokontophyta; AlgaeBiosorption; Dynamic characteristic; Competitiveness; Selectivity; Breakthrough curve; Sorption; Adsorption isotherm; Sargassum; Nickel; Copper; Marine algaPhaeophyceae; Heterokontophyta; AlgaeBiosorción; Característica dinámica; Competitividad; Selectividad; Curva ruptura; Sorción; Isotermo adsorción; Sargassum; Niquel; Cobre; Alga marinaINIST-18769.35400019279158003011-0159826 001682 Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cellsB. L. SantosLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.A. R. SilvaLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.B. P. S. PitangaLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.C. S. SousaLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.M. S. GrangeiroLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.B. O. FragomeniLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.P. L. C. CoelhoLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.M. N. OliveiraLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.N. J. Menezes-FilhoLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.M. F. D. CostaLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.R. S. El-BachaLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.E. S. VelozoLaboratório de Química Médica e Produtos Naturais, Faculdade de Farmácia, Universidade Federal da Bahia (UFBA), Rua Barão de Jeremoabo, s/n, Campus Universitário de Ondina40170-115 Salvador-BABRA12 aut.G. P. SampaioLaboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA13 aut.14 aut.S. M. FreireLaboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA13 aut.14 aut.M. TardyUniversité PARIS XII Val-de-Marne, 61 Avenue du Cénéral de Gaulle94010 CréteilFRA15 aut.S. L. CostaLaboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.11-01601952011PASCAL 11-0160195 INISTPascal:11-01601950012180308-8146Food chem.Food chemistryAntineoplastic agentDifferentiationFlavonoidHumanAnticancéreuxFlavonoïdeHommeDifférenciation
In this study, we investigated the effects of the flavonoid rutin (3,3',4',5,7-pentahydroxyflavone-3-rutino-side) on glioma cells, using the highly proliferative human cell line GL-15 as a model. We observed that rutin (50-100 μM) reduced proliferation and viability of GL-15 cells, leading to decreased levels of ERK1/ 2 phosphorylation (P-ERK1/2) and accumulation of cells in the G2 phase of the cell cycle. On the other hand, 87.4% of GL-15 cells exposed to 100 μM rutin entered apoptosis, as revealed by flow cytometry after AnnexinV/PI staining. Nuclear condensation and DNA fragmentation were also observed, further confirming that apoptosis had occurred. Moreover, the remaining cells that were treated with 50 μM rutin presented a morphological pattern of astroglial differentiation in culture, characterised by a condensed cell body and thin processes with overexpression of GFAP. Because of its capacity to induce differentiation and apoptosis in cultured human glioblastoma cells, rutin could be considered as a potential candidate for malignant gliomas treatment.
0308-8146FOCHDJFood chem.1272Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cellsSANTOS (B. L.)SILVA (A. R.)PITANGA (B. P. S.)SOUSA (C. S.)GRANGEIRO (M. S.)FRAGOMENI (B. O.)COELHO (P. L. C.)OLIVEIRA (M. N.)MENEZES-FILHO (N. J.)COSTA (M. F. D.)EL-BACHA (R. S.)VELOZO (E. S.)SAMPAIO (G. P.)FREIRE (S. M.)TARDY (M.)COSTA (S. L.)Laboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.7 aut.8 aut.9 aut.10 aut.11 aut.16 aut.Laboratório de Química Médica e Produtos Naturais, Faculdade de Farmácia, Universidade Federal da Bahia (UFBA), Rua Barão de Jeremoabo, s/n, Campus Universitário de Ondina40170-115 Salvador-BABRA12 aut.Laboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela40110-100 Salvador-BABRA13 aut.14 aut.Université PARIS XII Val-de-Marne, 61 Avenue du Cénéral de Gaulle94010 CréteilFRA15 aut.404-4112011ENGINIST178103540001927974500400000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0160195PAFood chemistryGBRIn this study, we investigated the effects of the flavonoid rutin (3,3',4',5,7-pentahydroxyflavone-3-rutino-side) on glioma cells, using the highly proliferative human cell line GL-15 as a model. We observed that rutin (50-100 μM) reduced proliferation and viability of GL-15 cells, leading to decreased levels of ERK1/ 2 phosphorylation (P-ERK1/2) and accumulation of cells in the G2 phase of the cell cycle. On the other hand, 87.4% of GL-15 cells exposed to 100 μM rutin entered apoptosis, as revealed by flow cytometry after AnnexinV/PI staining. Nuclear condensation and DNA fragmentation were also observed, further confirming that apoptosis had occurred. Moreover, the remaining cells that were treated with 50 μM rutin presented a morphological pattern of astroglial differentiation in culture, characterised by a condensed cell body and thin processes with overexpression of GFAP. Because of its capacity to induce differentiation and apoptosis in cultured human glioblastoma cells, rutin could be considered as a potential candidate for malignant gliomas treatment.002A35Anticancéreux01Antineoplastic agent01Anticanceroso01Flavonoïde02Flavonoid02Flavonoide02Homme10Human10Hombre10Différenciation19Differentiation19Diferenciación19Polyphénol08Polyphenol08Polifenol08101OTOOTOPASCAL 11-0160195 INISTAntiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cellsSANTOS (B. L.); SILVA (A. R.); PITANGA (B. P. S.); SOUSA (C. S.); GRANGEIRO (M. S.); FRAGOMENI (B. O.); COELHO (P. L. C.); OLIVEIRA (M. N.); MENEZES-FILHO (N. J.); COSTA (M. F. D.); EL-BACHA (R. S.); VELOZO (E. S.); SAMPAIO (G. P.); FREIRE (S. M.); TARDY (M.); COSTA (S. L.)Laboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela/40110-100 Salvador-BA/Brésil (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 10 aut., 11 aut., 16 aut.); Laboratório de Química Médica e Produtos Naturais, Faculdade de Farmácia, Universidade Federal da Bahia (UFBA), Rua Barão de Jeremoabo, s/n, Campus Universitário de Ondina/40170-115 Salvador-BA/Brésil (12 aut.); Laboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Av. Reitor Miguel Calmon s/n, Vale do Canela/40110-100 Salvador-BA/Brésil (13 aut., 14 aut.); Université PARIS XII Val-de-Marne, 61 Avenue du Cénéral de Gaulle/94010 Créteil/France (15 aut.)
Publication en série; Niveau analytique
Food chemistry; ISSN 0308-8146; Coden FOCHDJ; Royaume-Uni; Da. 2011; Vol. 127; No. 2; Pp. 404-411; Bibl. 3/4 p.AnglaisIn this study, we investigated the effects of the flavonoid rutin (3,3',4',5,7-pentahydroxyflavone-3-rutino-side) on glioma cells, using the highly proliferative human cell line GL-15 as a model. We observed that rutin (50-100 μM) reduced proliferation and viability of GL-15 cells, leading to decreased levels of ERK1/ 2 phosphorylation (P-ERK1/2) and accumulation of cells in the G2 phase of the cell cycle. On the other hand, 87.4% of GL-15 cells exposed to 100 μM rutin entered apoptosis, as revealed by flow cytometry after AnnexinV/PI staining. Nuclear condensation and DNA fragmentation were also observed, further confirming that apoptosis had occurred. Moreover, the remaining cells that were treated with 50 μM rutin presented a morphological pattern of astroglial differentiation in culture, characterised by a condensed cell body and thin processes with overexpression of GFAP. Because of its capacity to induce differentiation and apoptosis in cultured human glioblastoma cells, rutin could be considered as a potential candidate for malignant gliomas treatment.002A35Anticancéreux; Flavonoïde; Homme; DifférenciationPolyphénolAntineoplastic agent; Flavonoid; Human; DifferentiationPolyphenolAnticanceroso; Flavonoide; Hombre; DiferenciaciónINIST-17810.35400019279745004011-0160195 001683 UNCOVERING OBSCURED ACTIVE GALACTIC NUCLEI IN HOMOGENEOUSLY SELECTED SAMPLES OF SEYFERT 2 GALAXIESStephanie M. LamassaDepartment of Physics and Astronomy, The Johns Hopkins UniversityBaltimore, MDUSA1 aut.2 aut.6 aut.T. M. HeckmanDepartment of Physics and Astronomy, The Johns Hopkins UniversityBaltimore, MDUSA1 aut.2 aut.6 aut.A. PtakNASA Goddard Space Flight CenterGreenbelt, MD 20771USA3 aut.7 aut.L. MartinsNAT, Universidade Cruzeiro do SulSão PauloBRA4 aut.V. WildInstitut d'Astrophysique de Paris75014 ParisFRA5 aut.P. SonnentruckerDepartment of Physics and Astronomy, The Johns Hopkins UniversityBaltimore, MDUSA1 aut.2 aut.6 aut.A. HornschemeierNASA Goddard Space Flight CenterGreenbelt, MD 20771USA3 aut.7 aut.11-01612282011PASCAL 11-0161228 INISTPascal:11-01612280012170004-637XAstrophys. j.The Astrophysical journalAccretion rateActive galaxiesActive galaxy nucleiAttenuationBlack holesColumn densityContinuumCosmic x-ray sourcesCosmologyEquivalent widthFormation rateGalaxy nucleiInfrared galaxiesLuminosityModelsSeyfert 2 galaxiesSeyfert galaxiesSky surveysStar formationX-ray galaxieskeV rangeNoyau galactique actifGalaxies Seyfert type 2Etude cielDensité colonneAtténuationLargeur équivalenteDomaine énergie keVContinuumModèleLuminositéTrou noirTaux accrétionFormation stellaireTaux formationGalaxies activesGalaxies SeyfertGalaxies infrarougesGalaxies RXNoyau galaxiesCosmologieSource RX cosmique
We have analyzed archival Chandra and XMM-Newton data for two nearly complete homogeneously selected samples of type 2 Seyfert galaxies (Sy2s). These samples were selected based on intrinsic active galactic nuclei (AGNs) flux proxies: a mid-infrared (MIR) sample from the original IRAS 12 μm survey and an optical ([O III]λ 5007 flux limited) sample from the Sloan Digital Sky Survey, providing a total of 45 Sy2s. As the MIR and [O III] fluxes are largely unaffected by AGN obscuration, these samples can present an unbiased estimate of the Compton-thick (column density NH > 1024 cm-2) subpopulation. We find that the majority of this combined sample are likely heavily obscured, as evidenced by the 2-10 keV X-ray attenuation (normalized by intrinsic flux diagnostics) and the large Fe Kα equivalent widths (several hundred eV to over 1 keV). A wide range of these obscuration diagnostics is present, showing a continuum of column densities, rather than a clear segregation into Compton-thick and Compton-thin sub-populations. We find that, in several instances, the fitted column densities severely underrepresent the attenuation implied by these obscuration diagnostics, indicating that simple X-ray models may not always recover the intrinsic absorption. We compared AGNs and host galaxy properties, such as intrinsic luminosity, central black hole mass, accretion rate, and star formation rate with obscuration diagnostics. No convincing evidence exists to link obscured sources with unique host galaxy populations from their less absorbed counterparts. Finally, we estimate that a majority of these Seyfert 2s will be detectable in the 10-40 keV range by the future NuSTAR mission, which would confirm whether these heavily absorbed sources are indeed Compton-thick.
0004-637XASJOABAstrophys. j.7291p. 1UNCOVERING OBSCURED ACTIVE GALACTIC NUCLEI IN HOMOGENEOUSLY SELECTED SAMPLES OF SEYFERT 2 GALAXIESLAMASSA (Stephanie M.)HECKMAN (T. M.)PTAK (A.)MARTINS (L.)WILD (V.)SONNENTRUCKER (P.)HORNSCHEMEIER (A.)Department of Physics and Astronomy, The Johns Hopkins UniversityBaltimore, MDUSA1 aut.2 aut.6 aut.NASA Goddard Space Flight CenterGreenbelt, MD 20771USA3 aut.7 aut.NAT, Universidade Cruzeiro do SulSão PauloBRA4 aut.Institut d'Astrophysique de Paris75014 ParisFRA5 aut.72952.1-72952.282011ENGINIST5123540001944312705200000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0161228PAThe Astrophysical journalGBRWe have analyzed archival Chandra and XMM-Newton data for two nearly complete homogeneously selected samples of type 2 Seyfert galaxies (Sy2s). These samples were selected based on intrinsic active galactic nuclei (AGNs) flux proxies: a mid-infrared (MIR) sample from the original IRAS 12 μm survey and an optical ([O III]λ 5007 flux limited) sample from the Sloan Digital Sky Survey, providing a total of 45 Sy2s. As the MIR and [O III] fluxes are largely unaffected by AGN obscuration, these samples can present an unbiased estimate of the Compton-thick (column density NH > 1024 cm-2) subpopulation. We find that the majority of this combined sample are likely heavily obscured, as evidenced by the 2-10 keV X-ray attenuation (normalized by intrinsic flux diagnostics) and the large Fe Kα equivalent widths (several hundred eV to over 1 keV). A wide range of these obscuration diagnostics is present, showing a continuum of column densities, rather than a clear segregation into Compton-thick and Compton-thin sub-populations. We find that, in several instances, the fitted column densities severely underrepresent the attenuation implied by these obscuration diagnostics, indicating that simple X-ray models may not always recover the intrinsic absorption. We compared AGNs and host galaxy properties, such as intrinsic luminosity, central black hole mass, accretion rate, and star formation rate with obscuration diagnostics. No convincing evidence exists to link obscured sources with unique host galaxy populations from their less absorbed counterparts. Finally, we estimate that a majority of these Seyfert 2s will be detectable in the 10-40 keV range by the future NuSTAR mission, which would confirm whether these heavily absorbed sources are indeed Compton-thick.001E03Noyau galactique actif26Active galaxy nuclei26Galaxies Seyfert type 227Seyfert 2 galaxies27Galaxias Seyfert tipo 227Etude ciel28Sky surveys28Densité colonne29Column density29Densidad columna29Atténuation30Attenuation30Largeur équivalente31Equivalent width31Anchura equivalente31Domaine énergie keV32keV range32Continuum33Continuum33Continuo33Modèle34Models34Modelo34Luminosité35Luminosity35Trou noir36Black holes36Taux accrétion37Accretion rate37Índice acreción37Formation stellaire38Star formation38Taux formation39Formation rate39Grado formación39Galaxies actives40Active galaxies40Galaxies Seyfert41Seyfert galaxies41Galaxies infrarouges42Infrared galaxies42Galaxias infrarrojas42Galaxies RX43X-ray galaxies43Noyau galaxies44Galaxy nuclei44Cosmologie45Cosmology45Source RX cosmique46Cosmic x-ray sources46101OTOOTOPASCAL 11-0161228 INISTUNCOVERING OBSCURED ACTIVE GALACTIC NUCLEI IN HOMOGENEOUSLY SELECTED SAMPLES OF SEYFERT 2 GALAXIESLAMASSA (Stephanie M.); HECKMAN (T. M.); PTAK (A.); MARTINS (L.); WILD (V.); SONNENTRUCKER (P.); HORNSCHEMEIER (A.)Department of Physics and Astronomy, The Johns Hopkins University/Baltimore, MD/Etats-Unis (1 aut., 2 aut., 6 aut.); NASA Goddard Space Flight Center/Greenbelt, MD 20771/Etats-Unis (3 aut., 7 aut.); NAT, Universidade Cruzeiro do Sul/São Paulo/Brésil (4 aut.); Institut d'Astrophysique de Paris/75014 Paris/France (5 aut.)
Publication en série; Niveau analytique
The Astrophysical journal; ISSN 0004-637X; Coden ASJOAB; Royaume-Uni; Da. 2011; Vol. 729; No. 1 p. 1; 72952.1-72952.28; Bibl. 3/4 p.AnglaisWe have analyzed archival Chandra and XMM-Newton data for two nearly complete homogeneously selected samples of type 2 Seyfert galaxies (Sy2s). These samples were selected based on intrinsic active galactic nuclei (AGNs) flux proxies: a mid-infrared (MIR) sample from the original IRAS 12 μm survey and an optical ([O III]λ 5007 flux limited) sample from the Sloan Digital Sky Survey, providing a total of 45 Sy2s. As the MIR and [O III] fluxes are largely unaffected by AGN obscuration, these samples can present an unbiased estimate of the Compton-thick (column density NH > 1024 cm-2) subpopulation. We find that the majority of this combined sample are likely heavily obscured, as evidenced by the 2-10 keV X-ray attenuation (normalized by intrinsic flux diagnostics) and the large Fe Kα equivalent widths (several hundred eV to over 1 keV). A wide range of these obscuration diagnostics is present, showing a continuum of column densities, rather than a clear segregation into Compton-thick and Compton-thin sub-populations. We find that, in several instances, the fitted column densities severely underrepresent the attenuation implied by these obscuration diagnostics, indicating that simple X-ray models may not always recover the intrinsic absorption. We compared AGNs and host galaxy properties, such as intrinsic luminosity, central black hole mass, accretion rate, and star formation rate with obscuration diagnostics. No convincing evidence exists to link obscured sources with unique host galaxy populations from their less absorbed counterparts. Finally, we estimate that a majority of these Seyfert 2s will be detectable in the 10-40 keV range by the future NuSTAR mission, which would confirm whether these heavily absorbed sources are indeed Compton-thick.001E03Noyau galactique actif; Galaxies Seyfert type 2; Etude ciel; Densité colonne; Atténuation; Largeur équivalente; Domaine énergie keV; Continuum; Modèle; Luminosité; Trou noir; Taux accrétion; Formation stellaire; Taux formation; Galaxies actives; Galaxies Seyfert; Galaxies infrarouges; Galaxies RX; Noyau galaxies; Cosmologie; Source RX cosmiqueActive galaxy nuclei; Seyfert 2 galaxies; Sky surveys; Column density; Attenuation; Equivalent width; keV range; Continuum; Models; Luminosity; Black holes; Accretion rate; Star formation; Formation rate; Active galaxies; Seyfert galaxies; Infrared galaxies; X-ray galaxies; Galaxy nuclei; Cosmology; Cosmic x-ray sourcesGalaxias Seyfert tipo 2; Densidad columna; Anchura equivalente; Continuo; Modelo; Índice acreción; Grado formación; Galaxias infrarrojasINIST-512.35400019443127052011-0161228 001684 Comparison of MMF efficacy and safety in paediatric vs. adult renal transplantation: subgroup analysis of the randomised, multicentre FDCC trialBritta HöckerUniversity Children's Hospital HeidelbergDEU1 aut.9 aut.Teun Van GelderDepartments of Hospital Pharmacy and Internal Medicine, Erasmus Medical CentreRotterdamNLD2 aut.Juan Martin-GovantesHospital Virgen del RocioSevillaESP3 aut.Paula MachadoHospital do Rim e HipertensaoSao PauloBRA4 aut.5 aut.Helio TedescoHospital do Rim e HipertensaoSao PauloBRA4 aut.5 aut.Jacek RubikChildren's Memorial Health InstituteWarsawPOL6 aut.Maud DehennaultHopital Jeanne de FlandresLilleFRA7 aut.Carmen Garcia MeseguerLa PazMadridESP8 aut.Burkhard TönshoffUniversity Children's Hospital HeidelbergDEU1 aut.9 aut.11-01626372011PASCAL 11-0162637 INISTPascal:11-01626370012160931-0509Nephrol. dial. transplant. : (Print)Nephrology, dialysis, transplantation : (Print)ChildComparative studyExtrarenal dialysisHemodialysisImmunomodulatorImmunosuppressive agentMycophenolate mofetilRenal failureInsuffisance rénaleEtude comparativeEnfantMycophénolate mofétilHémodialyseEpuration extrarénaleImmunomodulateurImmunodépresseur
Background. Mycophenolate mofetil (MMF) is widely used for immunosuppressive therapy in renal transplantation, but comparative data regarding efficacy and safety in paediatric vs. adult kidney allograft recipients in one and the same study are lacking. Methods. We therefore performed this subgroup analysis of the FDCC trial, a 12-month, prospective, randomised study, comparing fixed-dose (FD) with concentration-controlled (CC) MMF dosing in paediatric and adult renal transplant recipients. Sixty-two paediatric and 839 adult de novo patients in 19 countries were randomised 1:1 to receive fixed-dose or concentration-controlled MMF therapy in combination with calcineurin inhibitors and corticosteroids. Results. Both patient and allograft survival proved to be excellent in paediatric patients (98.4% and 90.3%) and adults (96.8% and 95.0%). The rates of biopsy-proven acute rejections (BPAR) and treated acute rejection episodes (ARE) were comparable between paediatric (12.9% and 17.7%) and adult patients (15.5% and 20.7%). Transplant function at 12 months post-transplant was similar in paediatric (67.8 ± 45.6 mL/min/1.73 m2) and adult recipients (64.7 ± 23.3 mL/min/1.73 m2). Children <6 years (n = 10) exhibited a numerically higher frequency of leucocytopaenia (20%), diarrhoea (40%) and weight loss (10%) than older children (6-18 years; 5.8%, 28.8% and 1.9%) and adults (16.1%, 24.7% and 1.5%). On the whole, the percentage of patients who experienced adverse events causing interruption of MMF therapy were numerically lower in children (4.8%) than in adults (12.5%). Conclusions. The overall efficacy and tolerability of MMF appear to be comparable between paediatric and adult patients. Further studies are needed to validate these results.
0931-0509NDTREANephrol. dial. transplant. : (Print)263Comparison of MMF efficacy and safety in paediatric vs. adult renal transplantation: subgroup analysis of the randomised, multicentre FDCC trialHÖCKER (Britta)VAN GELDER (Teun)MARTIN-GOVANTES (Juan)MACHADO (Paula)TEDESCO (Helio)RUBIK (Jacek)DEHENNAULT (Maud)GARCIA MESEGUER (Carmen)TÖNSHOFF (Burkhard)University Children's Hospital HeidelbergDEU1 aut.9 aut.Departments of Hospital Pharmacy and Internal Medicine, Erasmus Medical CentreRotterdamNLD2 aut.Hospital Virgen del RocioSevillaESP3 aut.Hospital do Rim e HipertensaoSao PauloBRA4 aut.5 aut.Children's Memorial Health InstituteWarsawPOL6 aut.Hopital Jeanne de FlandresLilleFRA7 aut.La PazMadridESP8 aut.FDCC Study GroupINC1073-10792011ENGINIST212153540001907661204600000© 2011 INIST-CNRS. All rights reserved.18 ref.11-0162637PANephrology, dialysis, transplantation : (Print)GBRBackground. Mycophenolate mofetil (MMF) is widely used for immunosuppressive therapy in renal transplantation, but comparative data regarding efficacy and safety in paediatric vs. adult kidney allograft recipients in one and the same study are lacking. Methods. We therefore performed this subgroup analysis of the FDCC trial, a 12-month, prospective, randomised study, comparing fixed-dose (FD) with concentration-controlled (CC) MMF dosing in paediatric and adult renal transplant recipients. Sixty-two paediatric and 839 adult de novo patients in 19 countries were randomised 1:1 to receive fixed-dose or concentration-controlled MMF therapy in combination with calcineurin inhibitors and corticosteroids. Results. Both patient and allograft survival proved to be excellent in paediatric patients (98.4% and 90.3%) and adults (96.8% and 95.0%). The rates of biopsy-proven acute rejections (BPAR) and treated acute rejection episodes (ARE) were comparable between paediatric (12.9% and 17.7%) and adult patients (15.5% and 20.7%). Transplant function at 12 months post-transplant was similar in paediatric (67.8 ± 45.6 mL/min/1.73 m2) and adult recipients (64.7 ± 23.3 mL/min/1.73 m2). Children <6 years (n = 10) exhibited a numerically higher frequency of leucocytopaenia (20%), diarrhoea (40%) and weight loss (10%) than older children (6-18 years; 5.8%, 28.8% and 1.9%) and adults (16.1%, 24.7% and 1.5%). On the whole, the percentage of patients who experienced adverse events causing interruption of MMF therapy were numerically lower in children (4.8%) than in adults (12.5%). Conclusions. The overall efficacy and tolerability of MMF appear to be comparable between paediatric and adult patients. Further studies are needed to validate these results.002B27B03002B25HInsuffisance rénale01Renal failure01Insuficiencia renal01Etude comparative09Comparative study09Estudio comparativo09Enfant10Child10Niño10Mycophénolate mofétilFR11Mycophenolate mofetilFR11Micofenolato mofetilFR11Hémodialyse12Hemodialysis12Hemodiálisis12Epuration extrarénale13Extrarenal dialysis13Depuración extrarrenal13Immunomodulateur78Immunomodulator78Inmunomodulador78Immunodépresseur79Immunosuppressive agent79Inmunodepresor79HommeHumanHombreInhibiteur enzyme37Enzyme inhibitor37Inhibidor enzima37IMP dehydrogenaseFE38IMP dehydrogenaseFE38IMP dehydrogenaseFE38OxidoreductasesFEOxidoreductasesFEOxidoreductasesFEEnzymeFEEnzymeFEEnzimaFEPathologie de l'appareil urinaire39Urinary system disease39Aparato urinario patología39Pathologie du rein40Kidney disease40Riñón patología40101OTOOTOPASCAL 11-0162637 INISTComparison of MMF efficacy and safety in paediatric vs. adult renal transplantation: subgroup analysis of the randomised, multicentre FDCC trialHÖCKER (Britta); VAN GELDER (Teun); MARTIN-GOVANTES (Juan); MACHADO (Paula); TEDESCO (Helio); RUBIK (Jacek); DEHENNAULT (Maud); GARCIA MESEGUER (Carmen); TÖNSHOFF (Burkhard)University Children's Hospital Heidelberg/Allemagne (1 aut., 9 aut.); Departments of Hospital Pharmacy and Internal Medicine, Erasmus Medical Centre/Rotterdam/Pays-Bas (2 aut.); Hospital Virgen del Rocio/Sevilla/Espagne (3 aut.); Hospital do Rim e Hipertensao/Sao Paulo/Brésil (4 aut., 5 aut.); Children's Memorial Health Institute/Warsaw/Pologne (6 aut.); Hopital Jeanne de Flandres/Lille/France (7 aut.); La Paz/Madrid/Espagne (8 aut.)
Publication en série; Niveau analytique
Nephrology, dialysis, transplantation : (Print); ISSN 0931-0509; Coden NDTREA; Royaume-Uni; Da. 2011; Vol. 26; No. 3; Pp. 1073-1079; Bibl. 18 ref.AnglaisBackground. Mycophenolate mofetil (MMF) is widely used for immunosuppressive therapy in renal transplantation, but comparative data regarding efficacy and safety in paediatric vs. adult kidney allograft recipients in one and the same study are lacking. Methods. We therefore performed this subgroup analysis of the FDCC trial, a 12-month, prospective, randomised study, comparing fixed-dose (FD) with concentration-controlled (CC) MMF dosing in paediatric and adult renal transplant recipients. Sixty-two paediatric and 839 adult de novo patients in 19 countries were randomised 1:1 to receive fixed-dose or concentration-controlled MMF therapy in combination with calcineurin inhibitors and corticosteroids. Results. Both patient and allograft survival proved to be excellent in paediatric patients (98.4% and 90.3%) and adults (96.8% and 95.0%). The rates of biopsy-proven acute rejections (BPAR) and treated acute rejection episodes (ARE) were comparable between paediatric (12.9% and 17.7%) and adult patients (15.5% and 20.7%). Transplant function at 12 months post-transplant was similar in paediatric (67.8 ± 45.6 mL/min/1.73 m2) and adult recipients (64.7 ± 23.3 mL/min/1.73 m2). Children <6 years (n = 10) exhibited a numerically higher frequency of leucocytopaenia (20%), diarrhoea (40%) and weight loss (10%) than older children (6-18 years; 5.8%, 28.8% and 1.9%) and adults (16.1%, 24.7% and 1.5%). On the whole, the percentage of patients who experienced adverse events causing interruption of MMF therapy were numerically lower in children (4.8%) than in adults (12.5%). Conclusions. The overall efficacy and tolerability of MMF appear to be comparable between paediatric and adult patients. Further studies are needed to validate these results.002B27B03; 002B25HInsuffisance rénale; Etude comparative; Enfant; Mycophénolate mofétil; Hémodialyse; Epuration extrarénale; Immunomodulateur; ImmunodépresseurHomme; Inhibiteur enzyme; IMP dehydrogenase; Oxidoreductases; Enzyme; Pathologie de l'appareil urinaire; Pathologie du reinRenal failure; Comparative study; Child; Mycophenolate mofetil; Hemodialysis; Extrarenal dialysis; Immunomodulator; Immunosuppressive agentHuman; Enzyme inhibitor; IMP dehydrogenase; Oxidoreductases; Enzyme; Urinary system disease; Kidney diseaseInsuficiencia renal; Estudio comparativo; Niño; Micofenolato mofetil; Hemodiálisis; Depuración extrarrenal; Inmunomodulador; InmunodepresorINIST-21215.35400019076612046011-0162637 001685 Irradiation Stability of Folic Acid in Powder and Aqueous SolutionMichel M. AraujoInstituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP), Centro de Tecnologia das Radiações, Av. Prof. Lineu Prestes, 224205508-910, São PauloBRA1 aut.7 aut.Eric MarchioniEquipe de Chimie Analytique des Molécules Bioactives (IPHC-LC4, UMR 7178), Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin67400 IllkirchFRA2 aut.3 aut.4 aut.6 aut.Martine BergaentzleEquipe de Chimie Analytique des Molécules Bioactives (IPHC-LC4, UMR 7178), Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin67400 IllkirchFRA2 aut.3 aut.4 aut.6 aut.MINJIE ZHAOEquipe de Chimie Analytique des Molécules Bioactives (IPHC-LC4, UMR 7178), Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin67400 IllkirchFRA2 aut.3 aut.4 aut.6 aut.Florent KuntzAérial, Centre de Ressources Technologiques, Parc d'Innovation, rue Laurent Fries, B.P. 4044367412 IllkirchFRA5 aut.Emeline HahnEquipe de Chimie Analytique des Molécules Bioactives (IPHC-LC4, UMR 7178), Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin67400 IllkirchFRA2 aut.3 aut.4 aut.6 aut.Anna Lucia C. H. VillavicencioInstituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP), Centro de Tecnologia das Radiações, Av. Prof. Lineu Prestes, 224205508-910, São PauloBRA1 aut.7 aut.11-01637042011PASCAL 11-0163704 INISTPascal:11-01637040012150021-8561J. agric. food chem. : (Print)Journal of agricultural and food chemistry : (Print)Aqueous solutionFolic acidIrradiationPowderQualityRadiationStabilityWheat flourIrradiationStabilitéAcide foliquePoudreSolution aqueuseRayonnementFarine bléQualité
This study attempts to examine the folic acid stability after irradiation treatment, under different physical states, pH values, and atmosphere conditions. Aqueous folic acid samples, folic acid in powder, and wheat flour fortified with folic add were irradiated by an electron beam (E-beam) between 0 (control) and 10.0 kGy. It was realized that the physical state of folic acid plays an important role on its stability toward E-beam processing, being largely unstable in solution, no matter the pH and atmosphere conditions assayed. Otherwise, folic acid in powder showed huge irradiation stability, even when mixed in a dry food matrix, such as fortified wheat flour samples.
0021-8561JAFCAUJ. agric. food chem. : (Print)594Irradiation Stability of Folic Acid in Powder and Aqueous SolutionARAUJO (Michel M.)MARCHIONI (Eric)BERGAENTZLE (Martine)MINJIE ZHAOKUNTZ (Florent)HAHN (Emeline)VILLAVICENCIO (Anna Lucia C. H.)Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP), Centro de Tecnologia das Radiações, Av. Prof. Lineu Prestes, 224205508-910, São PauloBRA1 aut.7 aut.Equipe de Chimie Analytique des Molécules Bioactives (IPHC-LC4, UMR 7178), Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin67400 IllkirchFRA2 aut.3 aut.4 aut.6 aut.Aérial, Centre de Ressources Technologiques, Parc d'Innovation, rue Laurent Fries, B.P. 4044367412 IllkirchFRA5 aut.1244-12482011ENGINIST73323540001920151702800000© 2011 INIST-CNRS. All rights reserved.31 ref.11-0163704PAJournal of agricultural and food chemistry : (Print)USAThis study attempts to examine the folic acid stability after irradiation treatment, under different physical states, pH values, and atmosphere conditions. Aqueous folic acid samples, folic acid in powder, and wheat flour fortified with folic add were irradiated by an electron beam (E-beam) between 0 (control) and 10.0 kGy. It was realized that the physical state of folic acid plays an important role on its stability toward E-beam processing, being largely unstable in solution, no matter the pH and atmosphere conditions assayed. Otherwise, folic acid in powder showed huge irradiation stability, even when mixed in a dry food matrix, such as fortified wheat flour samples.002A35B03Irradiation01Irradiation01Irradiación01Stabilité02Stability02Estabilidad02Acide foliqueNKFR10Folic acidNKFR10Acido fólicoNKFR10Poudre11Powder11Polvo11Solution aqueuse12Aqueous solution12Solución acuosa12Rayonnement19Radiation19Radiación19Farine blé20Wheat flour20Harina trigo20Qualité21Quality21Calidad21Produit céréalier23Cereal product23Producto de cereal23101OTOOTOPASCAL 11-0163704 INISTIrradiation Stability of Folic Acid in Powder and Aqueous SolutionARAUJO (Michel M.); MARCHIONI (Eric); BERGAENTZLE (Martine); MINJIE ZHAO; KUNTZ (Florent); HAHN (Emeline); VILLAVICENCIO (Anna Lucia C. H.)Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP), Centro de Tecnologia das Radiações, Av. Prof. Lineu Prestes, 2242/05508-910, São Paulo/Brésil (1 aut., 7 aut.); Equipe de Chimie Analytique des Molécules Bioactives (IPHC-LC4, UMR 7178), Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin/67400 Illkirch/France (2 aut., 3 aut., 4 aut., 6 aut.); Aérial, Centre de Ressources Technologiques, Parc d'Innovation, rue Laurent Fries, B.P. 40443/67412 Illkirch/France (5 aut.)
Publication en série; Niveau analytique
Journal of agricultural and food chemistry : (Print); ISSN 0021-8561; Coden JAFCAU; Etats-Unis; Da. 2011; Vol. 59; No. 4; Pp. 1244-1248; Bibl. 31 ref.AnglaisThis study attempts to examine the folic acid stability after irradiation treatment, under different physical states, pH values, and atmosphere conditions. Aqueous folic acid samples, folic acid in powder, and wheat flour fortified with folic add were irradiated by an electron beam (E-beam) between 0 (control) and 10.0 kGy. It was realized that the physical state of folic acid plays an important role on its stability toward E-beam processing, being largely unstable in solution, no matter the pH and atmosphere conditions assayed. Otherwise, folic acid in powder showed huge irradiation stability, even when mixed in a dry food matrix, such as fortified wheat flour samples.002A35B03Irradiation; Stabilité; Acide folique; Poudre; Solution aqueuse; Rayonnement; Farine blé; QualitéProduit céréalierIrradiation; Stability; Folic acid; Powder; Aqueous solution; Radiation; Wheat flour; QualityCereal productIrradiación; Estabilidad; Acido fólico; Polvo; Solución acuosa; Radiación; Harina trigo; CalidadINIST-7332.35400019201517028011-0163704 001686 Transiting exoplanets from the CoRoT space mission: XIV. CoRoT-11b: a transiting massive "hot-Jupiter" in a prograde orbit around a rapidly rotating F-type starD. GandolfiThüringer Landessternwarte, Sternwarte 5, Tautenburg07778 TautenburgDEU1 aut.5 aut.8 aut.25 aut.33 aut.34 aut.52 aut.55 aut.Research and Scientific Support Department, ESTEC/ESA, PO Box 2992200 AG NoordwijkNLD1 aut.6 aut.20 aut.31 aut.Dpto. de Astrofisica, Universidad de La Laguna38206 La Laguna, TenerifeESPLaboratoire d'Astronomie de Lille, Université de Lille 1, 1 impasse de l'Observatoire59000 LilleFRAInstitut de Mécanique Céleste et de Calcul des Ephémérides, UMR 8028 du CNRS, 77 avenue Denfert-Rochereau75014 ParisFRAG. HebrardInstitut d'Astrophysique de Paris, UMR7095 CNRS, Université Pierre & Marie Curie, 98bis boulevard Arago75014 ParisFRA2 aut.17 aut.R. AlonsoObservatoire de l'Université de Genève, 51 chemin des Maillettes1290 SauvernyCHE3 aut.30 aut.41 aut.46 aut.47 aut.54 aut.M. DeleuilLaboratoire d'Astrophysique de Marseille, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA4 aut.14 aut.15 aut.28 aut.35 aut.38 aut.43 aut.E. W. GuentherThüringer Landessternwarte, Sternwarte 5, Tautenburg07778 TautenburgDEU1 aut.5 aut.8 aut.25 aut.33 aut.34 aut.52 aut.55 aut.M. FridlundResearch and Scientific Support Department, ESTEC/ESA, PO Box 2992200 AG NoordwijkNLD1 aut.6 aut.20 aut.31 aut.M. EndlMcDonald Observatory, University of Texas at AustinAustin, TX 78712USA7 aut.22 aut.40 aut.P. Eigm LlerThüringer Landessternwarte, Sternwarte 5, Tautenburg07778 TautenburgDEU1 aut.5 aut.8 aut.25 aut.33 aut.34 aut.52 aut.55 aut.Sz. CsizmadiaInstitute of Planetary Research, German Aerospace Center, Rutherfordstrasse 212489 BerlinDEU9 aut.19 aut.26 aut.36 aut.48 aut.M. HavelUniversité de Nice-Sophia Antipolis, CNRS UMR 6202, Observatoire de la Côte d'Azur, BP 422906304 NiceFRA10 aut.28 aut.32 aut.S. AigrainOxford Astrophyiscs, Denys Wilkinson Building, Keble RoadOxford OX1 3RHGBR11 aut.29 aut.M. AuvergneLESIA, Observatoire de Paris, Place Jules Janssen92195 MeudonFRA12 aut.13 aut.18 aut.49 aut.A. BaglinLESIA, Observatoire de Paris, Place Jules Janssen92195 MeudonFRA12 aut.13 aut.18 aut.49 aut.P. BargeLaboratoire d'Astrophysique de Marseille, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA4 aut.14 aut.15 aut.28 aut.35 aut.38 aut.43 aut.A. S. BonomoLaboratoire d'Astrophysique de Marseille, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA4 aut.14 aut.15 aut.28 aut.35 aut.38 aut.43 aut.P. BordeInstitut d'Astrophysique Spatiale, Université Paris XI91405 OrsayFRA16 aut.37 aut.44 aut.50 aut.F. BouchyInstitut d'Astrophysique de Paris, UMR7095 CNRS, Université Pierre & Marie Curie, 98bis boulevard Arago75014 ParisFRA2 aut.17 aut.Observatoire de Haute Provence04670 Saint Michel l'ObservatoireFRA17 aut.H. BrunttLESIA, Observatoire de Paris, Place Jules Janssen92195 MeudonFRA12 aut.13 aut.18 aut.49 aut.J. CabreraInstitute of Planetary Research, German Aerospace Center, Rutherfordstrasse 212489 BerlinDEU9 aut.19 aut.26 aut.36 aut.48 aut.LUTH, Observatoire de Paris, CNRS, Université Paris Diderot, 5 place Jules Janssen92195 MeudonFRA19 aut.51 aut.S. CarpanoResearch and Scientific Support Department, ESTEC/ESA, PO Box 2992200 AG NoordwijkNLD1 aut.6 aut.20 aut.31 aut.L. CaroneRheinisches Institut für Umweltforschung an der Universität zu Köln, Aachener Strasse 20950931 KölnDEU21 aut.45 aut.W. D. CochranMcDonald Observatory, University of Texas at AustinAustin, TX 78712USA7 aut.22 aut.40 aut.H. J. DeegInstituto de Astrofisica de Canarias38205 La Laguna, TenerifeESP23 aut.53 aut.R. DvorakUniversity of Vienna, Institute of Astronomy, Türkenschanzstr. 171180 ViennaAUT24 aut.J. EislöffelThüringer Landessternwarte, Sternwarte 5, Tautenburg07778 TautenburgDEU1 aut.5 aut.8 aut.25 aut.33 aut.34 aut.52 aut.55 aut.A. EriksonInstitute of Planetary Research, German Aerospace Center, Rutherfordstrasse 212489 BerlinDEU9 aut.19 aut.26 aut.36 aut.48 aut.S. Ferraz-MelloIAG, University of São PauloBRA27 aut.J.-C. GazzanoLaboratoire d'Astrophysique de Marseille, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA4 aut.14 aut.15 aut.28 aut.35 aut.38 aut.43 aut.Université de Nice-Sophia Antipolis, CNRS UMR 6202, Observatoire de la Côte d'Azur, BP 422906304 NiceFRA10 aut.28 aut.32 aut.N. B. GibsonOxford Astrophyiscs, Denys Wilkinson Building, Keble RoadOxford OX1 3RHGBR11 aut.29 aut.M. GillonObservatoire de l'Université de Genève, 51 chemin des Maillettes1290 SauvernyCHE3 aut.30 aut.41 aut.46 aut.47 aut.54 aut.University of Liège, Allée du 6 août 17, Sart TilmanLiègeBEL30 aut.P. GondoinResearch and Scientific Support Department, ESTEC/ESA, PO Box 2992200 AG NoordwijkNLD1 aut.6 aut.20 aut.31 aut.T. GuillotUniversité de Nice-Sophia Antipolis, CNRS UMR 6202, Observatoire de la Côte d'Azur, BP 422906304 NiceFRA10 aut.28 aut.32 aut.M. HartmannThüringer Landessternwarte, Sternwarte 5, Tautenburg07778 TautenburgDEU1 aut.5 aut.8 aut.25 aut.33 aut.34 aut.52 aut.55 aut.A. HazesThüringer Landessternwarte, Sternwarte 5, Tautenburg07778 TautenburgDEU1 aut.5 aut.8 aut.25 aut.33 aut.34 aut.52 aut.55 aut.L. JordaLaboratoire d'Astrophysique de Marseille, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA4 aut.14 aut.15 aut.28 aut.35 aut.38 aut.43 aut.P. KabathInstitute of Planetary Research, German Aerospace Center, Rutherfordstrasse 212489 BerlinDEU9 aut.19 aut.26 aut.36 aut.48 aut.European Southern Observatory, Alonso de Crdova 3107Casilla 19001, Santiago de ChileCHL36 aut.A. LegerInstitut d'Astrophysique Spatiale, Université Paris XI91405 OrsayFRA16 aut.37 aut.44 aut.50 aut.A. LlebariaLaboratoire d'Astrophysique de Marseille, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA4 aut.14 aut.15 aut.28 aut.35 aut.38 aut.43 aut.H. LammerSpace Research Institute, Austrian Academy of Science, Schmiedlstr. 68042 GrazAUT39 aut.P. J. MacqueenMcDonald Observatory, University of Texas at AustinAustin, TX 78712USA7 aut.22 aut.40 aut.M. MayorObservatoire de l'Université de Genève, 51 chemin des Maillettes1290 SauvernyCHE3 aut.30 aut.41 aut.46 aut.47 aut.54 aut.T. MazehSchool of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv UniversityTel AvivISR42 aut.C. MoutouLaboratoire d'Astrophysique de Marseille, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA4 aut.14 aut.15 aut.28 aut.35 aut.38 aut.43 aut.M. OllivierInstitut d'Astrophysique Spatiale, Université Paris XI91405 OrsayFRA16 aut.37 aut.44 aut.50 aut.M. P TzoldRheinisches Institut für Umweltforschung an der Universität zu Köln, Aachener Strasse 20950931 KölnDEU21 aut.45 aut.F. PepeObservatoire de l'Université de Genève, 51 chemin des Maillettes1290 SauvernyCHE3 aut.30 aut.41 aut.46 aut.47 aut.54 aut.D. QuelozObservatoire de l'Université de Genève, 51 chemin des Maillettes1290 SauvernyCHE3 aut.30 aut.41 aut.46 aut.47 aut.54 aut.H. RauerInstitute of Planetary Research, German Aerospace Center, Rutherfordstrasse 212489 BerlinDEU9 aut.19 aut.26 aut.36 aut.48 aut.Center for Astronomy and Astrophysics, TU Berlin, Hardenbergstr. 3610623 BerlinDEU48 aut.D. RouanLESIA, Observatoire de Paris, Place Jules Janssen92195 MeudonFRA12 aut.13 aut.18 aut.49 aut.B. SamuelInstitut d'Astrophysique Spatiale, Université Paris XI91405 OrsayFRA16 aut.37 aut.44 aut.50 aut.J. SchneiderLUTH, Observatoire de Paris, CNRS, Université Paris Diderot, 5 place Jules Janssen92195 MeudonFRA19 aut.51 aut.B. StecklumThüringer Landessternwarte, Sternwarte 5, Tautenburg07778 TautenburgDEU1 aut.5 aut.8 aut.25 aut.33 aut.34 aut.52 aut.55 aut.B. TingleyInstituto de Astrofisica de Canarias38205 La Laguna, TenerifeESP23 aut.53 aut.S. UdryObservatoire de l'Université de Genève, 51 chemin des Maillettes1290 SauvernyCHE3 aut.30 aut.41 aut.46 aut.47 aut.54 aut.G. WuchterlThüringer Landessternwarte, Sternwarte 5, Tautenburg07778 TautenburgDEU1 aut.5 aut.8 aut.25 aut.33 aut.34 aut.52 aut.55 aut.11-01639692010PASCAL 11-0163969 INISTPascal:11-01639690012140004-6361Astron. astrophys. : (Berl., Print)Astronomy and astrophysics : (Berlin. Print)AnomalyDwarf starsEnergy dissipationExtrasolar planetsF starsJupiter planetM starsModelsOrbitsPlanetary systemRadial velocityRapid rotationRotating starRotation speedSolar compositionPlanète extrasolairePlanète JupiterOrbiteRotation rapideEtoile rotationEtoile FEtoile naineEtoile MVitesse radialeAnomalieVitesse rotationModèleComposition solaireDissipation énergieSystème planétaire
The CoRoT exoplanet science team announces the discovery of CoRoT-11b, a fairly massive hot-Jupiter transiting a V = 12.9 mag F6 dwarf star (M* = 1.27 ± 0.05 M◦., R* = 1.37 ± 0.03 R◦., Teff = 6440 ± 120 K), with an orbital period of P = 2.994329 ± 0.000011 days and semi-major axis a = 0.0436 ± 0.005 AU. The detection of part of the radial velocity anomaly caused by the Rossiter-McLaughlin effect shows that the transit-like events detected by CoRoT are caused by a planet-sized transiting object in a prograde orbit.
0004-6361AAEJAFAstron. astrophys. : (Berl., Print)524Transiting exoplanets from the CoRoT space mission: XIV. CoRoT-11b: a transiting massive "hot-Jupiter" in a prograde orbit around a rapidly rotating F-type starGANDOLFI (D.)HEBRARD (G.)ALONSO (R.)DELEUIL (M.)GUENTHER (E. W.)FRIDLUND (M.)ENDL (M.)EIGMÜLLER (P.)CSIZMADIA (Sz.)HAVEL (M.)AIGRAIN (S.)AUVERGNE (M.)BAGLIN (A.)BARGE (P.)BONOMO (A. S.)BORDE (P.)BOUCHY (F.)BRUNTT (H.)CABRERA (J.)CARPANO (S.)CARONE (L.)COCHRAN (W. D.)DEEG (H. J.)DVORAK (R.)EISLÖFFEL (J.)ERIKSON (A.)FERRAZ-MELLO (S.)GAZZANO (J.-C.)GIBSON (N. B.)GILLON (M.)GONDOIN (P.)GUILLOT (T.)HARTMANN (M.)HAZES (A.)JORDA (L.)KABATH (P.)LEGER (A.)LLEBARIA (A.)LAMMER (H.)MACQUEEN (P. J.)MAYOR (M.)MAZEH (T.)MOUTOU (C.)OLLIVIER (M.)PÄTZOLD (M.)PEPE (F.)QUELOZ (D.)RAUER (H.)ROUAN (D.)SAMUEL (B.)SCHNEIDER (J.)STECKLUM (B.)TINGLEY (B.)UDRY (S.)WUCHTERL (G.)Thüringer Landessternwarte, Sternwarte 5, Tautenburg07778 TautenburgDEU1 aut.5 aut.8 aut.25 aut.33 aut.34 aut.52 aut.55 aut.Research and Scientific Support Department, ESTEC/ESA, PO Box 2992200 AG NoordwijkNLD1 aut.6 aut.20 aut.31 aut.Institut d'Astrophysique de Paris, UMR7095 CNRS, Université Pierre & Marie Curie, 98bis boulevard Arago75014 ParisFRA2 aut.17 aut.Observatoire de l'Université de Genève, 51 chemin des Maillettes1290 SauvernyCHE3 aut.30 aut.41 aut.46 aut.47 aut.54 aut.Laboratoire d'Astrophysique de Marseille, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA4 aut.14 aut.15 aut.28 aut.35 aut.38 aut.43 aut.McDonald Observatory, University of Texas at AustinAustin, TX 78712USA7 aut.22 aut.40 aut.Institute of Planetary Research, German Aerospace Center, Rutherfordstrasse 212489 BerlinDEU9 aut.19 aut.26 aut.36 aut.48 aut.Université de Nice-Sophia Antipolis, CNRS UMR 6202, Observatoire de la Côte d'Azur, BP 422906304 NiceFRA10 aut.28 aut.32 aut.Oxford Astrophyiscs, Denys Wilkinson Building, Keble RoadOxford OX1 3RHGBR11 aut.29 aut.LESIA, Observatoire de Paris, Place Jules Janssen92195 MeudonFRA12 aut.13 aut.18 aut.49 aut.Institut d'Astrophysique Spatiale, Université Paris XI91405 OrsayFRA16 aut.37 aut.44 aut.50 aut.Observatoire de Haute Provence04670 Saint Michel l'ObservatoireFRA17 aut.LUTH, Observatoire de Paris, CNRS, Université Paris Diderot, 5 place Jules Janssen92195 MeudonFRA19 aut.51 aut.Rheinisches Institut für Umweltforschung an der Universität zu Köln, Aachener Strasse 20950931 KölnDEU21 aut.45 aut.Instituto de Astrofisica de Canarias38205 La Laguna, TenerifeESP23 aut.53 aut.University of Vienna, Institute of Astronomy, Türkenschanzstr. 171180 ViennaAUT24 aut.IAG, University of São PauloBRA27 aut.University of Liège, Allée du 6 août 17, Sart TilmanLiègeBEL30 aut.European Southern Observatory, Alonso de Crdova 3107Casilla 19001, Santiago de ChileCHL36 aut.Space Research Institute, Austrian Academy of Science, Schmiedlstr. 68042 GrazAUT39 aut.School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv UniversityTel AvivISR42 aut.Center for Astronomy and Astrophysics, TU Berlin, Hardenbergstr. 3610623 BerlinDEU48 aut.Dpto. de Astrofisica, Universidad de La Laguna38206 La Laguna, TenerifeESPLaboratoire d'Astronomie de Lille, Université de Lille 1, 1 impasse de l'Observatoire59000 LilleFRAInstitut de Mécanique Céleste et de Calcul des Ephémérides, UMR 8028 du CNRS, 77 avenue Denfert-Rochereau75014 ParisFRA524A55.1-524A55.132010ENGINIST141763540001907055704900000© 2011 INIST-CNRS. All rights reserved.1/2 p.11-0163969PAAstronomy and astrophysics : (Berlin. Print)FRAThe CoRoT exoplanet science team announces the discovery of CoRoT-11b, a fairly massive hot-Jupiter transiting a V = 12.9 mag F6 dwarf star (M* = 1.27 ± 0.05 M◦., R* = 1.37 ± 0.03 R◦., Teff = 6440 ± 120 K), with an orbital period of P = 2.994329 ± 0.000011 days and semi-major axis a = 0.0436 ± 0.005 AU. The detection of part of the radial velocity anomaly caused by the Rossiter-McLaughlin effect shows that the transit-like events detected by CoRoT are caused by a planet-sized transiting object in a prograde orbit.001E03Planète extrasolaire26Extrasolar planets26Planète Jupiter27Jupiter planet27Orbite28Orbits28Rotation rapide29Rapid rotation29Rotación rápida29Etoile rotation30Rotating star30Estrella rotación30Etoile F31F stars31Etoile naine32Dwarf stars32Etoile M33M stars33Vitesse radiale34Radial velocity34Anomalie35Anomaly35Anomalía35Vitesse rotation36Rotation speed36Velocidad rotación36Modèle37Models37Modelo37Composition solaire38Solar composition38Dissipation énergie39Energy dissipation39Disipación energía39Système planétaire40Planetary system40Sistema planetario40101OTOOTOPASCAL 11-0163969 INISTTransiting exoplanets from the CoRoT space mission: XIV. CoRoT-11b: a transiting massive "hot-Jupiter" in a prograde orbit around a rapidly rotating F-type starGANDOLFI (D.); HEBRARD (G.); ALONSO (R.); DELEUIL (M.); GUENTHER (E. W.); FRIDLUND (M.); ENDL (M.); EIGMÜLLER (P.); CSIZMADIA (Sz.); HAVEL (M.); AIGRAIN (S.); AUVERGNE (M.); BAGLIN (A.); BARGE (P.); BONOMO (A. S.); BORDE (P.); BOUCHY (F.); BRUNTT (H.); CABRERA (J.); CARPANO (S.); CARONE (L.); COCHRAN (W. D.); DEEG (H. J.); DVORAK (R.); EISLÖFFEL (J.); ERIKSON (A.); FERRAZ-MELLO (S.); GAZZANO (J.-C.); GIBSON (N. B.); GILLON (M.); GONDOIN (P.); GUILLOT (T.); HARTMANN (M.); HAZES (A.); JORDA (L.); KABATH (P.); LEGER (A.); LLEBARIA (A.); LAMMER (H.); MACQUEEN (P. J.); MAYOR (M.); MAZEH (T.); MOUTOU (C.); OLLIVIER (M.); PÄTZOLD (M.); PEPE (F.); QUELOZ (D.); RAUER (H.); ROUAN (D.); SAMUEL (B.); SCHNEIDER (J.); STECKLUM (B.); TINGLEY (B.); UDRY (S.); WUCHTERL (G.)Thüringer Landessternwarte, Sternwarte 5, Tautenburg/07778 Tautenburg/Allemagne (1 aut., 5 aut., 8 aut., 25 aut., 33 aut., 34 aut., 52 aut., 55 aut.); Research and Scientific Support Department, ESTEC/ESA, PO Box 299/2200 AG Noordwijk/Pays-Bas (1 aut., 6 aut., 20 aut., 31 aut.); Institut d'Astrophysique de Paris, UMR7095 CNRS, Université Pierre & Marie Curie, 98bis boulevard Arago/75014 Paris/France (2 aut., 17 aut.); Observatoire de l'Université de Genève, 51 chemin des Maillettes/1290 Sauverny/Suisse (3 aut., 30 aut., 41 aut., 46 aut., 47 aut., 54 aut.); Laboratoire d'Astrophysique de Marseille, 38 rue Frédéric Joliot-Curie/13388 Marseille/France (4 aut., 14 aut., 15 aut., 28 aut., 35 aut., 38 aut., 43 aut.); McDonald Observatory, University of Texas at Austin/Austin, TX 78712/Etats-Unis (7 aut., 22 aut., 40 aut.); Institute of Planetary Research, German Aerospace Center, Rutherfordstrasse 2/12489 Berlin/Allemagne (9 aut., 19 aut., 26 aut., 36 aut., 48 aut.); Université de Nice-Sophia Antipolis, CNRS UMR 6202, Observatoire de la Côte d'Azur, BP 4229/06304 Nice/France (10 aut., 28 aut., 32 aut.); Oxford Astrophyiscs, Denys Wilkinson Building, Keble Road/Oxford OX1 3RH/Royaume-Uni (11 aut., 29 aut.); LESIA, Observatoire de Paris, Place Jules Janssen/92195 Meudon/France (12 aut., 13 aut., 18 aut., 49 aut.); Institut d'Astrophysique Spatiale, Université Paris XI/91405 Orsay/France (16 aut., 37 aut., 44 aut., 50 aut.); Observatoire de Haute Provence/04670 Saint Michel l'Observatoire/France (17 aut.); LUTH, Observatoire de Paris, CNRS, Université Paris Diderot, 5 place Jules Janssen/92195 Meudon/France (19 aut., 51 aut.); Rheinisches Institut für Umweltforschung an der Universität zu Köln, Aachener Strasse 209/50931 Köln/Allemagne (21 aut., 45 aut.); Instituto de Astrofisica de Canarias/38205 La Laguna, Tenerife/Espagne (23 aut., 53 aut.); University of Vienna, Institute of Astronomy, Türkenschanzstr. 17/1180 Vienna/Autriche (24 aut.); IAG, University of São Paulo/Brésil (27 aut.); University of Liège, Allée du 6 août 17, Sart Tilman/Liège/Belgique (30 aut.); European Southern Observatory, Alonso de Crdova 3107/Casilla 19001, Santiago de Chile/Chili (36 aut.); Space Research Institute, Austrian Academy of Science, Schmiedlstr. 6/8042 Graz/Autriche (39 aut.); School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University/Tel Aviv/Israël (42 aut.); Center for Astronomy and Astrophysics, TU Berlin, Hardenbergstr. 36/10623 Berlin/Allemagne (48 aut.); Dpto. de Astrofisica, Universidad de La Laguna/38206 La Laguna, Tenerife/Espagne; Laboratoire d'Astronomie de Lille, Université de Lille 1, 1 impasse de l'Observatoire/59000 Lille/France; Institut de Mécanique Céleste et de Calcul des Ephémérides, UMR 8028 du CNRS, 77 avenue Denfert-Rochereau/75014 Paris/France
Publication en série; Niveau analytique
Astronomy and astrophysics : (Berlin. Print); ISSN 0004-6361; Coden AAEJAF; France; Da. 2010; Vol. 524; 524A55.1-524A55.13; Bibl. 1/2 p.AnglaisThe CoRoT exoplanet science team announces the discovery of CoRoT-11b, a fairly massive hot-Jupiter transiting a V = 12.9 mag F6 dwarf star (M* = 1.27 ± 0.05 M◦., R* = 1.37 ± 0.03 R◦., Teff = 6440 ± 120 K), with an orbital period of P = 2.994329 ± 0.000011 days and semi-major axis a = 0.0436 ± 0.005 AU. The detection of part of the radial velocity anomaly caused by the Rossiter-McLaughlin effect shows that the transit-like events detected by CoRoT are caused by a planet-sized transiting object in a prograde orbit.001E03Planète extrasolaire; Planète Jupiter; Orbite; Rotation rapide; Etoile rotation; Etoile F; Etoile naine; Etoile M; Vitesse radiale; Anomalie; Vitesse rotation; Modèle; Composition solaire; Dissipation énergie; Système planétaireExtrasolar planets; Jupiter planet; Orbits; Rapid rotation; Rotating star; F stars; Dwarf stars; M stars; Radial velocity; Anomaly; Rotation speed; Models; Solar composition; Energy dissipation; Planetary systemRotación rápida; Estrella rotación; Anomalía; Velocidad rotación; Modelo; Disipación energía; Sistema planetarioINIST-14176.35400019070557049011-0163969 001687 The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods CommissionIngmar Bl MckeDepartment of Neuropathology, Institute of Neurology, University College LondonLondonGBR1 aut.Maria ThomDepartment of (Neuro)Pathology, Academic Medisch Centrum, University of Amsterdam and Stichting Epilepsie Instellingen NederlandHeemstedeNLD2 aut.Eleonora AronicaFormerly Baylor College of Medicine and Texas Children's HospitalHouston, TexasUSA3 aut.Dawna D. ArmstrongDepartments of Pathology and Laboratory Medicine (Neuropathology) and Neurology, UCLA Medical Center and David Geffen School of Medicine at UCLALos Angeles, CaliforniaUSA4 aut.Harry V. VintersServico de Neurologia, Hospital Sao Lucas da Pontifica Universidade Catolica do Rio Grande do SulPorto AlegreBRA5 aut.Andre PalminiUCL-Institute of Child Health and Great Ormond Street Hospital NHS TrustLondonGBR6 aut.Thomas S. JacquesDepartment of Epilepsy Clinic and Experimental Neurophysiology, IRCCS Foundation Neurological Institute "Carlo BestaMilanITA7 aut.31 aut.Giuliano AvanziniDepartment of Neuroradiology, University of California at San FranciscoSan Francisco, CaliforniaUSA8 aut.A. James BarkovichMolecular Neuroanatomy and Pathogenesis Unit, IRCCS Foundation Neurological Institute "Carlo BestaMilanITA9 aut.Giorgio BattagliaDepartment of Neuropathology, University Hospital BonnBonnDEU10 aut.Albert BeckerIDDRC, Semel Institute, UCLA Medical CenterLos Angeles, CaliforniaUSA11 aut.Carlos CepedaDepartment of Neurology, University of CampinasCampinasBRA12 aut.Fernando CendesDepartment of Neuroradiology, Ospedale NiguardaMilanITA13 aut.Nadia ColomboPENN Epilepsy Center, University of PennsylvaniaPhiladelphia, PennsylvaniaUSA14 aut.Peter CrinoThe Prince of Wales's Chair of Childhood Epilepsy, UCL-Institute of Child Health, Great Ormond Street Hospital for Children and National Centre for Young People with EpilepsyLondonGBR15 aut.J. Helen CrossFondation Ophthalmologique Rothschild, Service de Neurochirurgie PediatriqueParisFRA16 aut.Olivier DelalandeMontreal Neurological Institute, McGill UniversityMontreal, QuebecCAN17 aut.François DubeauJohn DuncanRenzo GuerriniPhilippe KahaneGary MathernImad NajmCi Gbreve Dem OzkaraCharles RaybaudAlfonso RepresaSteven N. RoperNoriko SalamonAndreas Schulze-BonhageLaura TassiAnnamaria VezzaniDepartment of Epilepsy Clinic and Experimental Neurophysiology, IRCCS Foundation Neurological Institute "Carlo BestaMilanITA7 aut.31 aut.Roberto SpreaficoDepartment of Neuropathology, University Hospital ErlangenErlangenDEU32 aut.11-01639782011PASCAL 11-0163978 INISTPascal:11-01639780012130013-9580Epilepsia : (Cph.)Epilepsia : (Copenhagen)ClassificationConvulsionDiagnosisDysplasiaEpilepsyForceHippocampusNervous system diseasesDysplasieEpilepsieConvulsionPathologie du système nerveuxClassificationForceDiagnosticHippocampe
Purpose: Focal cortical dysplasias (FCD) are localized regions of malformed cerebral cortex and are very frequently associated with epilepsy in both children and adults. A broad spectrum of histopathology has been included in the diagnosis of FCD. An ILAE task force proposes an international consensus classification system to better characterize specific clinicopathological FCD entities. Methods: Thirty-two Task Force members have reevaluated available data on electroclinical presentation, imaging, neuropathological examination of surgical specimens as well as postsurgical outcome. Key Findings: The ILAE Task Force proposes a three-tiered classification system. FCD Type I refers to isolated lesions, which present either as radial (FCD Type la) or tangential (FCD Type Ib) dyslamination of the neocortex, microscopically identified in one or multiple lobes. FCD Type II is an isolated lesion characterized by cortical dyslamination and dysmorphic neurons without (Type IIa) or with balloon cells (Type IIb). Hence, the major change since a prior classification represents the introduction of FCD Type III, which occurs in combination with hippocampal sclerosis (FCD Type IIIa), or with epilepsy-associated tumors (FCD Type IIIb). FCD Type IIIc is found adjacent to vascular malformations, whereas FCD Type IIId can be diagnosed in association with epileptogenic lesions acquired in early life (i.e., traumatic injury, ischemic injury or encephalitis). Significance: This three-tiered classification system will be an important basis to evaluate imaging, electroclinical features, and postsurgical seizure control as well as to explore underlying molecular pathomechanisms in FCD.
0013-9580EPILAKEpilepsia : (Cph.)521The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods CommissionBLÜMCKE (Ingmar)THOM (Maria)ARONICA (Eleonora)ARMSTRONG (Dawna D.)VINTERS (Harry V.)PALMINI (Andre)JACQUES (Thomas S.)AVANZINI (Giuliano)BARKOVICH (A. James)BATTAGLIA (Giorgio)BECKER (Albert)CEPEDA (Carlos)CENDES (Fernando)COLOMBO (Nadia)CRINO (Peter)CROSS (J. Helen)DELALANDE (Olivier)DUBEAU (François)DUNCAN (John)GUERRINI (Renzo)KAHANE (Philippe)MATHERN (Gary)NAJM (Imad)OZKARA (Ci========gbreve;dem)RAYBAUD (Charles)REPRESA (Alfonso)ROPER (Steven N.)SALAMON (Noriko)SCHULZE-BONHAGE (Andreas)TASSI (Laura)VEZZANI (Annamaria)SPREAFICO (Roberto)Department of Neuropathology, University Hospital ErlangenErlangenDEU32 aut.Department of Neuropathology, Institute of Neurology, University College LondonLondonGBR1 aut.Department of (Neuro)Pathology, Academic Medisch Centrum, University of Amsterdam and Stichting Epilepsie Instellingen NederlandHeemstedeNLD2 aut.Formerly Baylor College of Medicine and Texas Children's HospitalHouston, TexasUSA3 aut.Departments of Pathology and Laboratory Medicine (Neuropathology) and Neurology, UCLA Medical Center and David Geffen School of Medicine at UCLALos Angeles, CaliforniaUSA4 aut.Servico de Neurologia, Hospital Sao Lucas da Pontifica Universidade Catolica do Rio Grande do SulPorto AlegreBRA5 aut.UCL-Institute of Child Health and Great Ormond Street Hospital NHS TrustLondonGBR6 aut.Department of Epilepsy Clinic and Experimental Neurophysiology, IRCCS Foundation Neurological Institute "Carlo BestaMilanITA7 aut.31 aut.Department of Neuroradiology, University of California at San FranciscoSan Francisco, CaliforniaUSA8 aut.Molecular Neuroanatomy and Pathogenesis Unit, IRCCS Foundation Neurological Institute "Carlo BestaMilanITA9 aut.Department of Neuropathology, University Hospital BonnBonnDEU10 aut.IDDRC, Semel Institute, UCLA Medical CenterLos Angeles, CaliforniaUSA11 aut.Department of Neurology, University of CampinasCampinasBRA12 aut.Department of Neuroradiology, Ospedale NiguardaMilanITA13 aut.PENN Epilepsy Center, University of PennsylvaniaPhiladelphia, PennsylvaniaUSA14 aut.The Prince of Wales's Chair of Childhood Epilepsy, UCL-Institute of Child Health, Great Ormond Street Hospital for Children and National Centre for Young People with EpilepsyLondonGBR15 aut.Fondation Ophthalmologique Rothschild, Service de Neurochirurgie PediatriqueParisFRA16 aut.Montreal Neurological Institute, McGill UniversityMontreal, QuebecCAN17 aut.158-1742011ENGINIST11453540001919986901800000© 2011 INIST-CNRS. All rights reserved.1 p.3/411-0163978PCAEpilepsia : (Copenhagen)USAPurpose: Focal cortical dysplasias (FCD) are localized regions of malformed cerebral cortex and are very frequently associated with epilepsy in both children and adults. A broad spectrum of histopathology has been included in the diagnosis of FCD. An ILAE task force proposes an international consensus classification system to better characterize specific clinicopathological FCD entities. Methods: Thirty-two Task Force members have reevaluated available data on electroclinical presentation, imaging, neuropathological examination of surgical specimens as well as postsurgical outcome. Key Findings: The ILAE Task Force proposes a three-tiered classification system. FCD Type I refers to isolated lesions, which present either as radial (FCD Type la) or tangential (FCD Type Ib) dyslamination of the neocortex, microscopically identified in one or multiple lobes. FCD Type II is an isolated lesion characterized by cortical dyslamination and dysmorphic neurons without (Type IIa) or with balloon cells (Type IIb). Hence, the major change since a prior classification represents the introduction of FCD Type III, which occurs in combination with hippocampal sclerosis (FCD Type IIIa), or with epilepsy-associated tumors (FCD Type IIIb). FCD Type IIIc is found adjacent to vascular malformations, whereas FCD Type IIId can be diagnosed in association with epileptogenic lesions acquired in early life (i.e., traumatic injury, ischemic injury or encephalitis). Significance: This three-tiered classification system will be an important basis to evaluate imaging, electroclinical features, and postsurgical seizure control as well as to explore underlying molecular pathomechanisms in FCD.002B17A03002B17DDysplasie01Dysplasia01Displasia01Epilepsie02Epilepsy02Epilepsia02Convulsion03Convulsion03Convulsión03Pathologie du système nerveux04Nervous system diseases04Sistema nervioso patología04Classification09Classification09Clasificación09Force10Force10Fuerza10Diagnostic11Diagnosis11Diagnóstico11Hippocampe12Hippocampus12Hipocampo12Pathologie de l'encéphale37Cerebral disorder37Encéfalo patología37Pathologie du système nerveux central38Central nervous system disease38Sistema nervosio central patología38Trouble neurologique40Neurological disorder40Trastorno neurológico40Encéphale41Encephalon41Encéfalo41Système nerveux central42Central nervous system42Sistema nervioso central42101OTOOTOPASCAL 11-0163978 INISTThe clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods CommissionBLÜMCKE (Ingmar); THOM (Maria); ARONICA (Eleonora); ARMSTRONG (Dawna D.); VINTERS (Harry V.); PALMINI (Andre); JACQUES (Thomas S.); AVANZINI (Giuliano); BARKOVICH (A. James); BATTAGLIA (Giorgio); BECKER (Albert); CEPEDA (Carlos); CENDES (Fernando); COLOMBO (Nadia); CRINO (Peter); CROSS (J. Helen); DELALANDE (Olivier); DUBEAU (François); DUNCAN (John); GUERRINI (Renzo); KAHANE (Philippe); MATHERN (Gary); NAJM (Imad); OZKARA (Ci========gbreve;dem); RAYBAUD (Charles); REPRESA (Alfonso); ROPER (Steven N.); SALAMON (Noriko); SCHULZE-BONHAGE (Andreas); TASSI (Laura); VEZZANI (Annamaria); SPREAFICO (Roberto)Department of Neuropathology, University Hospital Erlangen/Erlangen/Allemagne (32 aut.); Department of Neuropathology, Institute of Neurology, University College London/London/Royaume-Uni (1 aut.); Department of (Neuro)Pathology, Academic Medisch Centrum, University of Amsterdam and Stichting Epilepsie Instellingen Nederland/Heemstede/Pays-Bas (2 aut.); Formerly Baylor College of Medicine and Texas Children's Hospital/Houston, Texas/Etats-Unis (3 aut.); Departments of Pathology and Laboratory Medicine (Neuropathology) and Neurology, UCLA Medical Center and David Geffen School of Medicine at UCLA/Los Angeles, California/Etats-Unis (4 aut.); Servico de Neurologia, Hospital Sao Lucas da Pontifica Universidade Catolica do Rio Grande do Sul/Porto Alegre/Brésil (5 aut.); UCL-Institute of Child Health and Great Ormond Street Hospital NHS Trust/London/Royaume-Uni (6 aut.); Department of Epilepsy Clinic and Experimental Neurophysiology, IRCCS Foundation Neurological Institute "Carlo Besta/Milan/Italie (7 aut., 31 aut.); Department of Neuroradiology, University of California at San Francisco/San Francisco, California/Etats-Unis (8 aut.); Molecular Neuroanatomy and Pathogenesis Unit, IRCCS Foundation Neurological Institute "Carlo Besta/Milan/Italie (9 aut.); Department of Neuropathology, University Hospital Bonn/Bonn/Allemagne (10 aut.); IDDRC, Semel Institute, UCLA Medical Center/Los Angeles, California/Etats-Unis (11 aut.); Department of Neurology, University of Campinas/Campinas/Brésil (12 aut.); Department of Neuroradiology, Ospedale Niguarda/Milan/Italie (13 aut.); PENN Epilepsy Center, University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (14 aut.); The Prince of Wales's Chair of Childhood Epilepsy, UCL-Institute of Child Health, Great Ormond Street Hospital for Children and National Centre for Young People with Epilepsy/London/Royaume-Uni (15 aut.); Fondation Ophthalmologique Rothschild, Service de Neurochirurgie Pediatrique/Paris/France (16 aut.); Montreal Neurological Institute, McGill University/Montreal, Quebec/Canada (17 aut.)
Publication en série; Compte-rendu; Niveau analytique
Epilepsia : (Copenhagen); ISSN 0013-9580; Coden EPILAK; Etats-Unis; Da. 2011; Vol. 52; No. 1; Pp. 158-174; Bibl. 1 p.3/4AnglaisPurpose: Focal cortical dysplasias (FCD) are localized regions of malformed cerebral cortex and are very frequently associated with epilepsy in both children and adults. A broad spectrum of histopathology has been included in the diagnosis of FCD. An ILAE task force proposes an international consensus classification system to better characterize specific clinicopathological FCD entities. Methods: Thirty-two Task Force members have reevaluated available data on electroclinical presentation, imaging, neuropathological examination of surgical specimens as well as postsurgical outcome. Key Findings: The ILAE Task Force proposes a three-tiered classification system. FCD Type I refers to isolated lesions, which present either as radial (FCD Type la) or tangential (FCD Type Ib) dyslamination of the neocortex, microscopically identified in one or multiple lobes. FCD Type II is an isolated lesion characterized by cortical dyslamination and dysmorphic neurons without (Type IIa) or with balloon cells (Type IIb). Hence, the major change since a prior classification represents the introduction of FCD Type III, which occurs in combination with hippocampal sclerosis (FCD Type IIIa), or with epilepsy-associated tumors (FCD Type IIIb). FCD Type IIIc is found adjacent to vascular malformations, whereas FCD Type IIId can be diagnosed in association with epileptogenic lesions acquired in early life (i.e., traumatic injury, ischemic injury or encephalitis). Significance: This three-tiered classification system will be an important basis to evaluate imaging, electroclinical features, and postsurgical seizure control as well as to explore underlying molecular pathomechanisms in FCD.002B17A03; 002B17DDysplasie; Epilepsie; Convulsion; Pathologie du système nerveux; Classification; Force; Diagnostic; HippocampePathologie de l'encéphale; Pathologie du système nerveux central; Trouble neurologique; Encéphale; Système nerveux centralDysplasia; Epilepsy; Convulsion; Nervous system diseases; Classification; Force; Diagnosis; HippocampusCerebral disorder; Central nervous system disease; Neurological disorder; Encephalon; Central nervous systemDisplasia; Epilepsia; Convulsión; Sistema nervioso patología; Clasificación; Fuerza; Diagnóstico; HipocampoINIST-1145.35400019199869018011-0163978 001688 Development of Lifetime Comorbidity in the World Health Organization World Mental Health SurveysRonald C. KesslerDepartment of Health Care Policy, Harvard Medical SchoolBoston, MassachusettsUSA1 aut.22 aut.23 aut.24 aut.25 aut.26 aut.Johan OrmelDepartment of Psychiatry, University Medical Center Groningen, and Graduate Schools of Behavioural and Cognitive Neuroscience and for Experimental Psychopathology, University of GroningenGroningenNLD2 aut.Maria PetukhovaShire Pharmaceuticals Research and DevelopmentChesterbrook, PennsylvaniaUSA3 aut.Katie A. MclaughlinDepartment of Psychiatry, University of Cape TownCape TownZAF4 aut.Jennifer Greif GreenSchool of Medicine, Center for Reducing Health Disparities, University of CaliforniaDavisUSA5 aut.Leo J. RussoHealth Services Research Unit, Institut Municipal d'Investigació Mèdica, Centro de Investigación Biomédica en Red (CIBER) en Epidemiologia y Salud PúblicaBarcelonaESP6 aut.Dan J. SteinSection of Psychiatric Epidemiology, Department and Institute of Psychiatry, School of Medicine, University of São PauloSão PauloBRA7 aut.Alan M. ZaslavskyNational Institute of PsychiatryMexico CityMEX8 aut.Sergio Aguilar-GaxiolaIstituto de Ricovero e Cura a Carattere Scientifico Centro S. Giovanni di Dio FatebenefratelliBresciaITA9 aut.Jordi AlonsoNetherlands Institute of Mental Health and AddictionUtrechtNLD10 aut.Laura AndradeDepartment of Psychiatry, University Hospital GasthuisbergLeuvenBEL11 aut.Corina BenjetSt George Hospital University Medical Center, Balamand University, and Faculty of Medicine, Institute for Development, Research, Advocacy and Applied Care, Medical Institute for Neuropsychological DisordersBeirutLBN12 aut.Giovanni De GirolamoParc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBER en Salud Mental, Sant Boi de LlobregatBarcelonaESP13 aut.Ron De GraafShenzhen Institute of Mental Health and Shenzhen Kangning HospitalShenzhenCHN14 aut.Koen DemyttenaereThe Chinese University of Hong KongShatinHKG15 aut.John FayyadHôpital Lariboisière Fernand Widal, Assistance Publique Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale U 705, Centre national de la recherché scientifique Unité Mixte de Recherche, 7157 University Paris Diderot and Paris DescartesParisFRA16 aut.Josep Maria HaroDepartment of Psychiatry, University of LeipzigLeipzigDEU17 aut.CHI YI HUNational School of Public Health and Health Services ManagementBucharestROU18 aut.Aimee KaramColegio Mayor de Cundinamarca UniversityBogotaCOL19 aut.Sing LeeAll India Institute of Medical SciencesNew DelhiIND20 aut.Jean-Pierre LepineEvidence and Information for Policy/Department of Health Financing and Stewardship, World Health OrganizationGenevaCHE21 aut.Herbert MatchsingerDepartment of Health Care Policy, Harvard Medical SchoolBoston, MassachusettsUSA1 aut.22 aut.23 aut.24 aut.25 aut.26 aut.Constanta Mihaescu-PintiaDepartment of Health Care Policy, Harvard Medical SchoolBoston, MassachusettsUSA1 aut.22 aut.23 aut.24 aut.25 aut.26 aut.Jose Posada-VillaDepartment of Health Care Policy, Harvard Medical SchoolBoston, MassachusettsUSA1 aut.22 aut.23 aut.24 aut.25 aut.26 aut.Rajesh SagarDepartment of Health Care Policy, Harvard Medical SchoolBoston, MassachusettsUSA1 aut.22 aut.23 aut.24 aut.25 aut.26 aut.T. Bedirhan St NDepartment of Health Care Policy, Harvard Medical SchoolBoston, MassachusettsUSA1 aut.22 aut.23 aut.24 aut.25 aut.26 aut.11-01648782011PASCAL 11-0164878 INISTPascal:11-0164878001212FRANCIS 11-0164878 INIST0003-990XArch. gen. psychiatryArchives of general psychiatryConcomitant diseaseHumanInternationalLatent variable modelMental disorderMental healthPublic healthRetrospectiveSocial environmentWHORétrospectiveTrouble psychiatriqueAssociation morbideOMSModèle variable latenteSanté mentaleSanté publiqueEnvironnement socialInternationalHomme
Context: Although numerous studies have examined the role of latent variables in the structure of comorbidity among mental disorders, none has examined their role in the development of comorbidity. Objective: To study the role of latent variables in the development of comorbidity among 18 lifetime DSM-IV disorders in the World Health Organization World Mental Health Surveys. Design: Nationally or regionally representative community surveys. Stetting: Fourteen countries. Participants: A total of 21229 survey respondents. Main Outcome Measures: First onset of 18 lifetime DSM-IV anxiety, mood, behavior, and substance disorders assessed retrospectively in the World Health Organization Composite International Diagnostic Interview. Results: Separate internalizing (anxiety and mood disorders) and externalizing (behavior and substance disorders) factors were found in exploratory factor analysis of lifetime disorders. Consistently significant positive time-lagged associations were found in survival analyses for virtually all temporally primary lifetime disorders predicting subsequent onset of other disorders. Within-domain (ie, internalizing or externalizing) associations were generally stronger than between-domain associations. Most time-lagged associations were explained by a model that assumed the existence of mediating latent internalizing and externalizing variables. Specific phobia and obsessive-compulsive disorder (internalizing) and hyperactivity and oppositional defiant disorders (externalizing) were the most important predictors. A small number of residual associations remained significant after controlling the latent variables. Conclusions: The good fit of the latent variable model suggests that common causal pathways account for most of the comorbidity among the disorders considered herein. These common pathways should be the focus of future research on the development of comorbidity, although several important pairwise associations that cannot be accounted for by latent variables also exist that warrant further focused study.
0003-990XARGPAQArch. gen. psychiatry681Development of Lifetime Comorbidity in the World Health Organization World Mental Health SurveysKESSLER (Ronald C.)ORMEL (Johan)PETUKHOVA (Maria)MCLAUGHLIN (Katie A.)GREIF GREEN (Jennifer)RUSSO (Leo J.)STEIN (Dan J.)ZASLAVSKY (Alan M.)AGUILAR-GAXIOLA (Sergio)ALONSO (Jordi)ANDRADE (Laura)BENJET (Corina)DE GIROLAMO (Giovanni)DE GRAAF (Ron)DEMYTTENAERE (Koen)FAYYAD (John)HARO (Josep Maria)CHI YI HUKARAM (Aimee)LEE (Sing)LEPINE (Jean-Pierre)MATCHSINGER (Herbert)MIHAESCU-PINTIA (Constanta)POSADA-VILLA (Jose)SAGAR (Rajesh)BEDIRHAN ÜSTÜN (T.)Department of Health Care Policy, Harvard Medical SchoolBoston, MassachusettsUSA1 aut.22 aut.23 aut.24 aut.25 aut.26 aut.Department of Psychiatry, University Medical Center Groningen, and Graduate Schools of Behavioural and Cognitive Neuroscience and for Experimental Psychopathology, University of GroningenGroningenNLD2 aut.Shire Pharmaceuticals Research and DevelopmentChesterbrook, PennsylvaniaUSA3 aut.Department of Psychiatry, University of Cape TownCape TownZAF4 aut.School of Medicine, Center for Reducing Health Disparities, University of CaliforniaDavisUSA5 aut.Health Services Research Unit, Institut Municipal d'Investigació Mèdica, Centro de Investigación Biomédica en Red (CIBER) en Epidemiologia y Salud PúblicaBarcelonaESP6 aut.Section of Psychiatric Epidemiology, Department and Institute of Psychiatry, School of Medicine, University of São PauloSão PauloBRA7 aut.National Institute of PsychiatryMexico CityMEX8 aut.Istituto de Ricovero e Cura a Carattere Scientifico Centro S. Giovanni di Dio FatebenefratelliBresciaITA9 aut.Netherlands Institute of Mental Health and AddictionUtrechtNLD10 aut.Department of Psychiatry, University Hospital GasthuisbergLeuvenBEL11 aut.St George Hospital University Medical Center, Balamand University, and Faculty of Medicine, Institute for Development, Research, Advocacy and Applied Care, Medical Institute for Neuropsychological DisordersBeirutLBN12 aut.Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBER en Salud Mental, Sant Boi de LlobregatBarcelonaESP13 aut.Shenzhen Institute of Mental Health and Shenzhen Kangning HospitalShenzhenCHN14 aut.The Chinese University of Hong KongShatinHKG15 aut.Hôpital Lariboisière Fernand Widal, Assistance Publique Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale U 705, Centre national de la recherché scientifique Unité Mixte de Recherche, 7157 University Paris Diderot and Paris DescartesParisFRA16 aut.Department of Psychiatry, University of LeipzigLeipzigDEU17 aut.National School of Public Health and Health Services ManagementBucharestROU18 aut.Colegio Mayor de Cundinamarca UniversityBogotaCOL19 aut.All India Institute of Medical SciencesNew DelhiIND20 aut.Evidence and Information for Policy/Department of Health Financing and Stewardship, World Health OrganizationGenevaCHE21 aut.90-1002011ENGINIST2048A3540001918820101000000© 2011 INIST-CNRS. All rights reserved.64 ref.11-0164878PAArchives of general psychiatryUSAContext: Although numerous studies have examined the role of latent variables in the structure of comorbidity among mental disorders, none has examined their role in the development of comorbidity. Objective: To study the role of latent variables in the development of comorbidity among 18 lifetime DSM-IV disorders in the World Health Organization World Mental Health Surveys. Design: Nationally or regionally representative community surveys. Stetting: Fourteen countries. Participants: A total of 21229 survey respondents. Main Outcome Measures: First onset of 18 lifetime DSM-IV anxiety, mood, behavior, and substance disorders assessed retrospectively in the World Health Organization Composite International Diagnostic Interview. Results: Separate internalizing (anxiety and mood disorders) and externalizing (behavior and substance disorders) factors were found in exploratory factor analysis of lifetime disorders. Consistently significant positive time-lagged associations were found in survival analyses for virtually all temporally primary lifetime disorders predicting subsequent onset of other disorders. Within-domain (ie, internalizing or externalizing) associations were generally stronger than between-domain associations. Most time-lagged associations were explained by a model that assumed the existence of mediating latent internalizing and externalizing variables. Specific phobia and obsessive-compulsive disorder (internalizing) and hyperactivity and oppositional defiant disorders (externalizing) were the most important predictors. A small number of residual associations remained significant after controlling the latent variables. Conclusions: The good fit of the latent variable model suggests that common causal pathways account for most of the comorbidity among the disorders considered herein. These common pathways should be the focus of future research on the development of comorbidity, although several important pairwise associations that cannot be accounted for by latent variables also exist that warrant further focused study.002B18C14Rétrospective01Retrospective01Retrospectiva01Trouble psychiatrique02Mental disorder02Trastorno psiquiátrico02Association morbide03Concomitant disease03Asociación morbosa03OMS04WHO04OMS04Modèle variable latente05Latent variable model05Modelo variable latente05Santé mentale06Mental health06Salud mental06Santé publique07Public health07Salud pública07Environnement social08Social environment08Contexto social08International09International09Internacional09Homme18Human18Hombre18108PASCAL 11-0164878 INISTDevelopment of Lifetime Comorbidity in the World Health Organization World Mental Health SurveysKESSLER (Ronald C.); ORMEL (Johan); PETUKHOVA (Maria); MCLAUGHLIN (Katie A.); GREIF GREEN (Jennifer); RUSSO (Leo J.); STEIN (Dan J.); ZASLAVSKY (Alan M.); AGUILAR-GAXIOLA (Sergio); ALONSO (Jordi); ANDRADE (Laura); BENJET (Corina); DE GIROLAMO (Giovanni); DE GRAAF (Ron); DEMYTTENAERE (Koen); FAYYAD (John); HARO (Josep Maria); CHI YI HU; KARAM (Aimee); LEE (Sing); LEPINE (Jean-Pierre); MATCHSINGER (Herbert); MIHAESCU-PINTIA (Constanta); POSADA-VILLA (Jose); SAGAR (Rajesh); BEDIRHAN ÜSTÜN (T.)Department of Health Care Policy, Harvard Medical School/Boston, Massachusetts/Etats-Unis (1 aut., 22 aut., 23 aut., 24 aut., 25 aut., 26 aut.); Department of Psychiatry, University Medical Center Groningen, and Graduate Schools of Behavioural and Cognitive Neuroscience and for Experimental Psychopathology, University of Groningen/Groningen/Pays-Bas (2 aut.); Shire Pharmaceuticals Research and Development/Chesterbrook, Pennsylvania/Etats-Unis (3 aut.); Department of Psychiatry, University of Cape Town/Cape Town/Afrique du Sud (4 aut.); School of Medicine, Center for Reducing Health Disparities, University of California/Davis/Etats-Unis (5 aut.); Health Services Research Unit, Institut Municipal d'Investigació Mèdica, Centro de Investigación Biomédica en Red (CIBER) en Epidemiologia y Salud Pública/Barcelona/Espagne (6 aut.); Section of Psychiatric Epidemiology, Department and Institute of Psychiatry, School of Medicine, University of São Paulo/São Paulo/Brésil (7 aut.); National Institute of Psychiatry/Mexico City/Mexique (8 aut.); Istituto de Ricovero e Cura a Carattere Scientifico Centro S. Giovanni di Dio Fatebenefratelli/Brescia/Italie (9 aut.); Netherlands Institute of Mental Health and Addiction/Utrecht/Pays-Bas (10 aut.); Department of Psychiatry, University Hospital Gasthuisberg/Leuven/Belgique (11 aut.); St George Hospital University Medical Center, Balamand University, and Faculty of Medicine, Institute for Development, Research, Advocacy and Applied Care, Medical Institute for Neuropsychological Disorders/Beirut/Liban (12 aut.); Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBER en Salud Mental, Sant Boi de Llobregat/Barcelona/Espagne (13 aut.); Shenzhen Institute of Mental Health and Shenzhen Kangning Hospital/Shenzhen/Chine (14 aut.); The Chinese University of Hong Kong/Shatin/Hong-Kong (15 aut.); Hôpital Lariboisière Fernand Widal, Assistance Publique Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale U 705, Centre national de la recherché scientifique Unité Mixte de Recherche, 7157 University Paris Diderot and Paris Descartes/Paris/France (16 aut.); Department of Psychiatry, University of Leipzig/Leipzig/Allemagne (17 aut.); National School of Public Health and Health Services Management/Bucharest/Roumanie (18 aut.); Colegio Mayor de Cundinamarca University/Bogota/Colombie (19 aut.); All India Institute of Medical Sciences/New Delhi/Inde (20 aut.); Evidence and Information for Policy/Department of Health Financing and Stewardship, World Health Organization/Geneva/Suisse (21 aut.)
Publication en série; Niveau analytique
Archives of general psychiatry; ISSN 0003-990X; Coden ARGPAQ; Etats-Unis; Da. 2011; Vol. 68; No. 1; Pp. 90-100; Bibl. 64 ref.AnglaisContext: Although numerous studies have examined the role of latent variables in the structure of comorbidity among mental disorders, none has examined their role in the development of comorbidity. Objective: To study the role of latent variables in the development of comorbidity among 18 lifetime DSM-IV disorders in the World Health Organization World Mental Health Surveys. Design: Nationally or regionally representative community surveys. Stetting: Fourteen countries. Participants: A total of 21229 survey respondents. Main Outcome Measures: First onset of 18 lifetime DSM-IV anxiety, mood, behavior, and substance disorders assessed retrospectively in the World Health Organization Composite International Diagnostic Interview. Results: Separate internalizing (anxiety and mood disorders) and externalizing (behavior and substance disorders) factors were found in exploratory factor analysis of lifetime disorders. Consistently significant positive time-lagged associations were found in survival analyses for virtually all temporally primary lifetime disorders predicting subsequent onset of other disorders. Within-domain (ie, internalizing or externalizing) associations were generally stronger than between-domain associations. Most time-lagged associations were explained by a model that assumed the existence of mediating latent internalizing and externalizing variables. Specific phobia and obsessive-compulsive disorder (internalizing) and hyperactivity and oppositional defiant disorders (externalizing) were the most important predictors. A small number of residual associations remained significant after controlling the latent variables. Conclusions: The good fit of the latent variable model suggests that common causal pathways account for most of the comorbidity among the disorders considered herein. These common pathways should be the focus of future research on the development of comorbidity, although several important pairwise associations that cannot be accounted for by latent variables also exist that warrant further focused study.002B18C14Rétrospective; Trouble psychiatrique; Association morbide; OMS; Modèle variable latente; Santé mentale; Santé publique; Environnement social; International; HommeRetrospective; Mental disorder; Concomitant disease; WHO; Latent variable model; Mental health; Public health; Social environment; International; HumanRetrospectiva; Trastorno psiquiátrico; Asociación morbosa; OMS; Modelo variable latente; Salud mental; Salud pública; Contexto social; Internacional; HombreINIST-2048A.35400019188201010011-0164878 001689 Thermodynamic Assessment of the Aluminum Corner of the AI-Fe-Mn-Si SystemJacques LacazeCIRIMAT, Université de Toulouse, ENSIACET, BP 4436231432 ToulouseFRA1 aut.Luiz ElenoDepartamento de Engenharia Metalúrgica e de Materiais, Escola Politécnica da Universidade de São Paulo, Av. Prof. Mello Morais, 246305508-030 São Paulo, SPBRA2 aut.B. O. SundmanINSTN, CEA Saclay91190 Gif sur YvetteFRA3 aut.11-01655902010PASCAL 11-0165590 INISTPascal:11-01655900012111073-5623Metall. mater. trans., A Phys. metall. mater. sci.Metallurgical and materials transactions. A, Physical metallurgy and materials scienceThermodynamicsThermodynamique
A new assessment of the aluminum corner of the quaternary Al-Fe-Mn-Si system has been made that extends beyond the COST-507 database. This assessment makes use of a recent, improved description of the ternary Al-Fe-Si system. In the present work, modeling of the Al-rich corner of the quaternary Al-Fe-Mn-Si system has been carried out by introducing Fe solubility into the so-called alpha-AlMnSi and beta-AlMnSi phases of the Al-Mn-Si system. A critical review of the data available on the quaternary system is presented and used for the extension of the description of these ternary phases into the quaternary Al-Fe-Mn-Si.
1073-5623MMTAEBMetall. mater. trans., A Phys. metall. mater. sci.419Thermodynamic Assessment of the Aluminum Corner of the AI-Fe-Mn-Si SystemLACAZE (Jacques)ELENO (Luiz)SUNDMAN (B. O.)CIRIMAT, Université de Toulouse, ENSIACET, BP 4436231432 ToulouseFRA1 aut.Departamento de Engenharia Metalúrgica e de Materiais, Escola Politécnica da Universidade de São Paulo, Av. Prof. Mello Morais, 246305508-030 São Paulo, SPBRA2 aut.INSTN, CEA Saclay91190 Gif sur YvetteFRA3 aut.2208-22152010ENGINIST3179A3540001941354200600000© 2011 INIST-CNRS. All rights reserved.35 ref.11-0165590PAMetallurgical and materials transactions. A, Physical metallurgy and materials scienceUSAA new assessment of the aluminum corner of the quaternary Al-Fe-Mn-Si system has been made that extends beyond the COST-507 database. This assessment makes use of a recent, improved description of the ternary Al-Fe-Si system. In the present work, modeling of the Al-rich corner of the quaternary Al-Fe-Mn-Si system has been carried out by introducing Fe solubility into the so-called alpha-AlMnSi and beta-AlMnSi phases of the Al-Mn-Si system. A critical review of the data available on the quaternary system is presented and used for the extension of the description of these ternary phases into the quaternary Al-Fe-Mn-Si.001D11A240Thermodynamique55Thermodynamics55Thermodynamik55Termodinámica55108OTOOTOPASCAL 11-0165590 INISTThermodynamic Assessment of the Aluminum Corner of the AI-Fe-Mn-Si SystemLACAZE (Jacques); ELENO (Luiz); SUNDMAN (B. O.)CIRIMAT, Université de Toulouse, ENSIACET, BP 44362/31432 Toulouse/France (1 aut.); Departamento de Engenharia Metalúrgica e de Materiais, Escola Politécnica da Universidade de São Paulo, Av. Prof. Mello Morais, 2463/05508-030 São Paulo, SP/Brésil (2 aut.); INSTN, CEA Saclay/91190 Gif sur Yvette/France (3 aut.)
Publication en série; Niveau analytique
Metallurgical and materials transactions. A, Physical metallurgy and materials science; ISSN 1073-5623; Coden MMTAEB; Etats-Unis; Da. 2010; Vol. 41; No. 9; Pp. 2208-2215; Bibl. 35 ref.AnglaisA new assessment of the aluminum corner of the quaternary Al-Fe-Mn-Si system has been made that extends beyond the COST-507 database. This assessment makes use of a recent, improved description of the ternary Al-Fe-Si system. In the present work, modeling of the Al-rich corner of the quaternary Al-Fe-Mn-Si system has been carried out by introducing Fe solubility into the so-called alpha-AlMnSi and beta-AlMnSi phases of the Al-Mn-Si system. A critical review of the data available on the quaternary system is presented and used for the extension of the description of these ternary phases into the quaternary Al-Fe-Mn-Si.001D11A; 240ThermodynamiqueThermodynamicsThermodynamikTermodinámicaINIST-3179A.35400019413542006011-0165590 001690 Photospheric activity, rotation, and star-planet interaction of the planet-hosting star CoRoT-6A. F. LanzaINAF - Osservatorio Astrofisico di Catania, via S. Sofia, 7895123 CataniaITA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.A. S. BonomoINAF - Osservatorio Astrofisico di Catania, via S. Sofia, 7895123 CataniaITA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.Laboratoire d'Astrophysique de Marseille (UMR 6110), Technopole de Chateau-Gombert, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA2 aut.7 aut.10 aut.11 aut.I. PaganoINAF - Osservatorio Astrofisico di Catania, via S. Sofia, 7895123 CataniaITA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.G. LetoINAF - Osservatorio Astrofisico di Catania, via S. Sofia, 7895123 CataniaITA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.S. MessinaINAF - Osservatorio Astrofisico di Catania, via S. Sofia, 7895123 CataniaITA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.G. CutispotoINAF - Osservatorio Astrofisico di Catania, via S. Sofia, 7895123 CataniaITA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.C. MoutouLaboratoire d'Astrophysique de Marseille (UMR 6110), Technopole de Chateau-Gombert, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA2 aut.7 aut.10 aut.11 aut.S. AigrainDepartment of Physics, University of Oxford, Denys Wilkinson Building, Keble RoadOxford OX1 3RHGBR8 aut.R. AlonsoObservatoire de Genève, Université de Genève, 51 Ch. des Maillettes1290 SauvernyCHE9 aut.P. BargeLaboratoire d'Astrophysique de Marseille (UMR 6110), Technopole de Chateau-Gombert, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA2 aut.7 aut.10 aut.11 aut.M. DeleuilLaboratoire d'Astrophysique de Marseille (UMR 6110), Technopole de Chateau-Gombert, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA2 aut.7 aut.10 aut.11 aut.M. FridlundResearch and Scientific Support Department, European Space Agency, Keplerlaan 12200AG, NoordwijkNLD12 aut.A. Silva-ValioCRAAM, Mackenzie University, rua de Consolação 89601302-907 São PauloBRA13 aut.M. AuvergneLESIA, CNRS UMR 8109, Observatoire de Paris, 5 place J. Janssen92195 MeudonFRA14 aut.15 aut.A. BaglinLESIA, CNRS UMR 8109, Observatoire de Paris, 5 place J. Janssen92195 MeudonFRA14 aut.15 aut.A. Collier CameronSchool of Physics and Astronomy, University of St. Andrews, North Haugh, St AndrewsFife KY16 9SS, ScotlandGBR16 aut.11-01657232011PASCAL 11-0165723 INISTPascal:11-01657230012100004-6361Astron. astrophys. : (Berl., Print)Astronomy and astrophysics : (Berlin. Print)CoRot satelliteDifferential rotationEntropyJupiter planetLate type starsLifetimeLower boundMagnetic fieldsMagnetic starsMain sequence starsModelsPlanetary systemProbabilityStellar activityStellar rotationRotation stellairePlanète JupiterEtoile séquence principaleModèleRotation différentielleEntropieDurée vieBorne inférieureProbabilitéEtoile magnétiqueChamp magnétiqueEtoile type avancéActivité stellaireSystème planétaireSatellite CoRot
Context. The CoRoT satellite has recently discovered a hot Jupiter that transits across the disc of a F9 main-sequence star called CoRoT-6 with a period of 8.886 days. Aims. We model the photospheric activity of the star and use the maps of the active regions to study stellar differential rotation and the star-planet interaction. Methods. We apply a maximum entropy spot model to fit the optical modulation as observed by CoRoT during a uninterrupted interval of ∼140 days. Photospheric active regions are assumed to consist of spots and faculae in a fixed proportion with solar-like contrasts. Results. Individual active regions have lifetimes up to 30-40 days. Most of them form and decay within five active longitudes whose different migration rates are attributed to the stellar differential rotation for which a lower limit of ΔΩ/Ω = 0.12 ± 0.02 is obtained. Several active regions show a maximum of activity at a longitude lagging the subplanetary point by ∼200° with the probability of a chance occurrence being smaller than 1 percent. Conclusions. Our spot modelling indicates that the photospheric activity of CoRoT-6 could be partially modulated by some kind of star-planet magnetic interaction, while an interaction related to tides is highly unlikely because of the weakness of the tidal force.
0004-6361AAEJAFAstron. astrophys. : (Berl., Print)525p. 1Photospheric activity, rotation, and star-planet interaction of the planet-hosting star CoRoT-6LANZA (A. F.)BONOMO (A. S.)PAGANO (I.)LETO (G.)MESSINA (S.)CUTISPOTO (G.)MOUTOU (C.)AIGRAIN (S.)ALONSO (R.)BARGE (P.)DELEUIL (M.)FRIDLUND (M.)SILVA-VALIO (A.)AUVERGNE (M.)BAGLIN (A.)COLLIER CAMERON (A.)INAF - Osservatorio Astrofisico di Catania, via S. Sofia, 7895123 CataniaITA1 aut.2 aut.3 aut.4 aut.5 aut.6 aut.Laboratoire d'Astrophysique de Marseille (UMR 6110), Technopole de Chateau-Gombert, 38 rue Frédéric Joliot-Curie13388 MarseilleFRA2 aut.7 aut.10 aut.11 aut.Department of Physics, University of Oxford, Denys Wilkinson Building, Keble RoadOxford OX1 3RHGBR8 aut.Observatoire de Genève, Université de Genève, 51 Ch. des Maillettes1290 SauvernyCHE9 aut.Research and Scientific Support Department, European Space Agency, Keplerlaan 12200AG, NoordwijkNLD12 aut.CRAAM, Mackenzie University, rua de Consolação 89601302-907 São PauloBRA13 aut.LESIA, CNRS UMR 8109, Observatoire de Paris, 5 place J. Janssen92195 MeudonFRA14 aut.15 aut.School of Physics and Astronomy, University of St. Andrews, North Haugh, St AndrewsFife KY16 9SS, ScotlandGBR16 aut.A14.1-A14.92011ENGINIST141763540001944463801900000© 2011 INIST-CNRS. All rights reserved.1/2 p.11-0165723PAAstronomy and astrophysics : (Berlin. Print)FRAContext. The CoRoT satellite has recently discovered a hot Jupiter that transits across the disc of a F9 main-sequence star called CoRoT-6 with a period of 8.886 days. Aims. We model the photospheric activity of the star and use the maps of the active regions to study stellar differential rotation and the star-planet interaction. Methods. We apply a maximum entropy spot model to fit the optical modulation as observed by CoRoT during a uninterrupted interval of ∼140 days. Photospheric active regions are assumed to consist of spots and faculae in a fixed proportion with solar-like contrasts. Results. Individual active regions have lifetimes up to 30-40 days. Most of them form and decay within five active longitudes whose different migration rates are attributed to the stellar differential rotation for which a lower limit of ΔΩ/Ω = 0.12 ± 0.02 is obtained. Several active regions show a maximum of activity at a longitude lagging the subplanetary point by ∼200° with the probability of a chance occurrence being smaller than 1 percent. Conclusions. Our spot modelling indicates that the photospheric activity of CoRoT-6 could be partially modulated by some kind of star-planet magnetic interaction, while an interaction related to tides is highly unlikely because of the weakness of the tidal force.001E03Rotation stellaire26Stellar rotation26Planète Jupiter27Jupiter planet27Etoile séquence principale28Main sequence stars28Modèle29Models29Modelo29Rotation différentielle30Differential rotation30Entropie31Entropy31Durée vie32Lifetime32Borne inférieure33Lower bound33Cota inferior33Probabilité34Probability34Etoile magnétique35Magnetic stars35Champ magnétique36Magnetic fields36Etoile type avancé37Late type stars37Activité stellaire38Stellar activity38Système planétaire39Planetary system39Sistema planetario39Satellite CoRotCD96CoRot satelliteCD96Satélite CoRotCD96108OTOOTOPASCAL 11-0165723 INISTPhotospheric activity, rotation, and star-planet interaction of the planet-hosting star CoRoT-6LANZA (A. F.); BONOMO (A. S.); PAGANO (I.); LETO (G.); MESSINA (S.); CUTISPOTO (G.); MOUTOU (C.); AIGRAIN (S.); ALONSO (R.); BARGE (P.); DELEUIL (M.); FRIDLUND (M.); SILVA-VALIO (A.); AUVERGNE (M.); BAGLIN (A.); COLLIER CAMERON (A.)INAF - Osservatorio Astrofisico di Catania, via S. Sofia, 78/95123 Catania/Italie (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Laboratoire d'Astrophysique de Marseille (UMR 6110), Technopole de Chateau-Gombert, 38 rue Frédéric Joliot-Curie/13388 Marseille/France (2 aut., 7 aut., 10 aut., 11 aut.); Department of Physics, University of Oxford, Denys Wilkinson Building, Keble Road/Oxford OX1 3RH/Royaume-Uni (8 aut.); Observatoire de Genève, Université de Genève, 51 Ch. des Maillettes/1290 Sauverny/Suisse (9 aut.); Research and Scientific Support Department, European Space Agency, Keplerlaan 1/2200AG, Noordwijk/Pays-Bas (12 aut.); CRAAM, Mackenzie University, rua de Consolação 896/01302-907 São Paulo/Brésil (13 aut.); LESIA, CNRS UMR 8109, Observatoire de Paris, 5 place J. Janssen/92195 Meudon/France (14 aut., 15 aut.); School of Physics and Astronomy, University of St. Andrews, North Haugh, St Andrews/Fife KY16 9SS, Scotland/Royaume-Uni (16 aut.)
Publication en série; Niveau analytique
Astronomy and astrophysics : (Berlin. Print); ISSN 0004-6361; Coden AAEJAF; France; Da. 2011; Vol. 525; No. p. 1; A14.1-A14.9; Bibl. 1/2 p.AnglaisContext. The CoRoT satellite has recently discovered a hot Jupiter that transits across the disc of a F9 main-sequence star called CoRoT-6 with a period of 8.886 days. Aims. We model the photospheric activity of the star and use the maps of the active regions to study stellar differential rotation and the star-planet interaction. Methods. We apply a maximum entropy spot model to fit the optical modulation as observed by CoRoT during a uninterrupted interval of ∼140 days. Photospheric active regions are assumed to consist of spots and faculae in a fixed proportion with solar-like contrasts. Results. Individual active regions have lifetimes up to 30-40 days. Most of them form and decay within five active longitudes whose different migration rates are attributed to the stellar differential rotation for which a lower limit of ΔΩ/Ω = 0.12 ± 0.02 is obtained. Several active regions show a maximum of activity at a longitude lagging the subplanetary point by ∼200° with the probability of a chance occurrence being smaller than 1 percent. Conclusions. Our spot modelling indicates that the photospheric activity of CoRoT-6 could be partially modulated by some kind of star-planet magnetic interaction, while an interaction related to tides is highly unlikely because of the weakness of the tidal force.001E03Rotation stellaire; Planète Jupiter; Etoile séquence principale; Modèle; Rotation différentielle; Entropie; Durée vie; Borne inférieure; Probabilité; Etoile magnétique; Champ magnétique; Etoile type avancé; Activité stellaire; Système planétaire; Satellite CoRotStellar rotation; Jupiter planet; Main sequence stars; Models; Differential rotation; Entropy; Lifetime; Lower bound; Probability; Magnetic stars; Magnetic fields; Late type stars; Stellar activity; Planetary system; CoRot satelliteModelo; Cota inferior; Sistema planetario; Satélite CoRotINIST-14176.35400019444638019011-0165723 001691 Fast ray-tracing algorithm for circumstellar structures (FRACS) II. Disc parameters of the B[e] supergiant CPD-57° 2874 from VLTI/MIDI dataA. Domiciano De SouzaLaboratoire H. Fizeau, UMR CNRS 6525, Université de Nice-Sophia Antipolis (UNS), Observatoire de la Côte d'Azur (OCA), Campus Valrose06108 NiceFRA1 aut.2 aut.3 aut.4 aut.5 aut.7 aut.8 aut.P. BendjoyaLaboratoire H. Fizeau, UMR CNRS 6525, Université de Nice-Sophia Antipolis (UNS), Observatoire de la Côte d'Azur (OCA), Campus Valrose06108 NiceFRA1 aut.2 aut.3 aut.4 aut.5 aut.7 aut.8 aut.G. NiccoliniLaboratoire H. Fizeau, UMR CNRS 6525, Université de Nice-Sophia Antipolis (UNS), Observatoire de la Côte d'Azur (OCA), Campus Valrose06108 NiceFRA1 aut.2 aut.3 aut.4 aut.5 aut.7 aut.8 aut.O. ChesneauLaboratoire H. Fizeau, UMR CNRS 6525, Université de Nice-Sophia Antipolis (UNS), Observatoire de la Côte d'Azur (OCA), Campus Valrose06108 NiceFRA1 aut.2 aut.3 aut.4 aut.5 aut.7 aut.8 aut.M. Borges FernandesLaboratoire H. Fizeau, UMR CNRS 6525, Université de Nice-Sophia Antipolis (UNS), Observatoire de la Côte d'Azur (OCA), Campus Valrose06108 NiceFRA1 aut.2 aut.3 aut.4 aut.5 aut.7 aut.8 aut.Observatório Nacional, Rua General José Cristino, 7720921-400 São Cristovao, Rio de JaneiroBRA5 aut.A. C. CarciofiInstituto de Astronomia, Geofísica e Ciências Atmosféricas, Universidade de São Paulo (USP), Rua do Matão 1226, Cidade UniversitáriaSão Paulo, SP - 05508-900BRA6 aut.A. SpangLaboratoire H. Fizeau, UMR CNRS 6525, Université de Nice-Sophia Antipolis (UNS), Observatoire de la Côte d'Azur (OCA), Campus Valrose06108 NiceFRA1 aut.2 aut.3 aut.4 aut.5 aut.7 aut.8 aut.P. SteeLaboratoire H. Fizeau, UMR CNRS 6525, Université de Nice-Sophia Antipolis (UNS), Observatoire de la Côte d'Azur (OCA), Campus Valrose06108 NiceFRA1 aut.2 aut.3 aut.4 aut.5 aut.7 aut.8 aut.T. DriebeMax-Planck-Institut fur Radioastronomie, Auf dem Hügel 6953121 BonnDEU9 aut.Deutsches Zentrum fur Luft- und Raumfahrt, Raumfahrt-Agentur, Königswinterer Strasse 522-52453227 BonnDEU9 aut.11-01657412011PASCAL 11-0165741 INISTPascal:11-01657410012090004-6361Astron. astrophys. : (Berl., Print)Astronomy and astrophysics : (Berlin. Print)AlgorithmsEmission line starsForbidden lineHot starInfrared observationInterferometric observationMain sequence starsMassive starsModelsNumerical methodPhysical parameterPhysical propertiesRadiative transferSupergiant starsUncertaintyVisibilityAlgorithmeSupergéanteEtoile séquence principaleRaie interditePropriété physiqueObservation IRObservation interférométriqueVisibilitéTransfert radiatifModèleIncertitudeParamètre physiqueEtoile chaudeEtoile massiveMéthode numériqueEtoile raie émission
Context. B[e] supergiants are luminous, massive post-main sequence stars exhibiting non-spherical winds, forbidden lines, and hot dust in a disc-like structure. The physical properties of their rich and complex circumstellar environment (CSE) are not well understood, partly because these CSE cannot be easily resolved at the large distances found for B[e] supergiants (typically ?1 kpc). Aims. From mid-IR spectro-interferometric observations obtained with VLTI/MIDI we seek to resolve and study the CSE of the Galactic B[e] supergiant CPD-57° 2874. Methods. For a physical interpretation of the observables (visibilities and spectrum) we use our ray-tracing radiative transfer code (FRACS), which is optimised for thermal spectro-interferometric observations. Results. Thanks to the short computing time required by FRACS (<10 s per monochromatic model), best-fit parameters and uncertainties for several physical quantities of CPD-57° 2874 were obtained, such as inner dust radius, relative flux contribution of the central source and of the dusty CSE, dust temperature profile, and disc inclination. Conclusions. The analysis of VLTI/MIDI data with FRACS allowed one of the first direct determinations of physical parameters of the dusty CSE of a B[e] supergiant based on interferometric data and using a full model-fitting approach. In a larger context, the study of B[e] supergiants is important for a deeper understanding of the complex structure and evolution of hot, massive stars.
0004-6361AAEJAFAstron. astrophys. : (Berl., Print)525p. 1Fast ray-tracing algorithm for circumstellar structures (FRACS) II. Disc parameters of the B[e] supergiant CPD-57° 2874 from VLTI/MIDI dataDE SOUZA (A. Domiciano)BENDJOYA (P.)NICCOLINI (G.)CHESNEAU (O.)BORGES FERNANDES (M.)CARCIOFI (A. C.)SPANG (A.)STEE (P.)DRIEBE (T.)Laboratoire H. Fizeau, UMR CNRS 6525, Université de Nice-Sophia Antipolis (UNS), Observatoire de la Côte d'Azur (OCA), Campus Valrose06108 NiceFRA1 aut.2 aut.3 aut.4 aut.5 aut.7 aut.8 aut.Observatório Nacional, Rua General José Cristino, 7720921-400 São Cristovao, Rio de JaneiroBRA5 aut.Instituto de Astronomia, Geofísica e Ciências Atmosféricas, Universidade de São Paulo (USP), Rua do Matão 1226, Cidade UniversitáriaSão Paulo, SP - 05508-900BRA6 aut.Max-Planck-Institut fur Radioastronomie, Auf dem Hügel 6953121 BonnDEU9 aut.Deutsches Zentrum fur Luft- und Raumfahrt, Raumfahrt-Agentur, Königswinterer Strasse 522-52453227 BonnDEU9 aut.A22.1-A22.82011ENGINIST141763540001944463802400000© 2011 INIST-CNRS. All rights reserved.1/4 p.11-0165741PAAstronomy and astrophysics : (Berlin. Print)FRAContext. B[e] supergiants are luminous, massive post-main sequence stars exhibiting non-spherical winds, forbidden lines, and hot dust in a disc-like structure. The physical properties of their rich and complex circumstellar environment (CSE) are not well understood, partly because these CSE cannot be easily resolved at the large distances found for B[e] supergiants (typically ?1 kpc). Aims. From mid-IR spectro-interferometric observations obtained with VLTI/MIDI we seek to resolve and study the CSE of the Galactic B[e] supergiant CPD-57° 2874. Methods. For a physical interpretation of the observables (visibilities and spectrum) we use our ray-tracing radiative transfer code (FRACS), which is optimised for thermal spectro-interferometric observations. Results. Thanks to the short computing time required by FRACS (<10 s per monochromatic model), best-fit parameters and uncertainties for several physical quantities of CPD-57° 2874 were obtained, such as inner dust radius, relative flux contribution of the central source and of the dusty CSE, dust temperature profile, and disc inclination. Conclusions. The analysis of VLTI/MIDI data with FRACS allowed one of the first direct determinations of physical parameters of the dusty CSE of a B[e] supergiant based on interferometric data and using a full model-fitting approach. In a larger context, the study of B[e] supergiants is important for a deeper understanding of the complex structure and evolution of hot, massive stars.001E03Algorithme26Algorithms26Supergéante27Supergiant stars27Etoile séquence principale28Main sequence stars28Raie interdite29Forbidden line29Raya prohibida29Propriété physique30Physical properties30Observation IR31Infrared observation31Observación IR31Observation interférométrique32Interferometric observation32Observación interferométrica32Visibilité33Visibility33Transfert radiatif34Radiative transfer34Modèle35Models35Modelo35Incertitude36Uncertainty36Incertidumbre36Paramètre physique37Physical parameter37Parámetro físico37Etoile chaude38Hot star38Estrella caliente38Etoile massive39Massive stars39Méthode numérique40Numerical method40Método numérico40Etoile raie émission41Emission line stars41108OTOOTOPASCAL 11-0165741 INISTFast ray-tracing algorithm for circumstellar structures (FRACS) II. Disc parameters of the B[e] supergiant CPD-57° 2874 from VLTI/MIDI dataDE SOUZA (A. Domiciano); BENDJOYA (P.); NICCOLINI (G.); CHESNEAU (O.); BORGES FERNANDES (M.); CARCIOFI (A. C.); SPANG (A.); STEE (P.); DRIEBE (T.)Laboratoire H. Fizeau, UMR CNRS 6525, Université de Nice-Sophia Antipolis (UNS), Observatoire de la Côte d'Azur (OCA), Campus Valrose/06108 Nice/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 7 aut., 8 aut.); Observatório Nacional, Rua General José Cristino, 77/20921-400 São Cristovao, Rio de Janeiro/Brésil (5 aut.); Instituto de Astronomia, Geofísica e Ciências Atmosféricas, Universidade de São Paulo (USP), Rua do Matão 1226, Cidade Universitária/São Paulo, SP - 05508-900/Brésil (6 aut.); Max-Planck-Institut fur Radioastronomie, Auf dem Hügel 69/53121 Bonn/Allemagne (9 aut.); Deutsches Zentrum fur Luft- und Raumfahrt, Raumfahrt-Agentur, Königswinterer Strasse 522-524/53227 Bonn/Allemagne (9 aut.)
Publication en série; Niveau analytique
Astronomy and astrophysics : (Berlin. Print); ISSN 0004-6361; Coden AAEJAF; France; Da. 2011; Vol. 525; No. p. 1; A22.1-A22.8; Bibl. 1/4 p.AnglaisContext. B[e] supergiants are luminous, massive post-main sequence stars exhibiting non-spherical winds, forbidden lines, and hot dust in a disc-like structure. The physical properties of their rich and complex circumstellar environment (CSE) are not well understood, partly because these CSE cannot be easily resolved at the large distances found for B[e] supergiants (typically ?1 kpc). Aims. From mid-IR spectro-interferometric observations obtained with VLTI/MIDI we seek to resolve and study the CSE of the Galactic B[e] supergiant CPD-57° 2874. Methods. For a physical interpretation of the observables (visibilities and spectrum) we use our ray-tracing radiative transfer code (FRACS), which is optimised for thermal spectro-interferometric observations. Results. Thanks to the short computing time required by FRACS (<10 s per monochromatic model), best-fit parameters and uncertainties for several physical quantities of CPD-57° 2874 were obtained, such as inner dust radius, relative flux contribution of the central source and of the dusty CSE, dust temperature profile, and disc inclination. Conclusions. The analysis of VLTI/MIDI data with FRACS allowed one of the first direct determinations of physical parameters of the dusty CSE of a B[e] supergiant based on interferometric data and using a full model-fitting approach. In a larger context, the study of B[e] supergiants is important for a deeper understanding of the complex structure and evolution of hot, massive stars.001E03Algorithme; Supergéante; Etoile séquence principale; Raie interdite; Propriété physique; Observation IR; Observation interférométrique; Visibilité; Transfert radiatif; Modèle; Incertitude; Paramètre physique; Etoile chaude; Etoile massive; Méthode numérique; Etoile raie émissionAlgorithms; Supergiant stars; Main sequence stars; Forbidden line; Physical properties; Infrared observation; Interferometric observation; Visibility; Radiative transfer; Models; Uncertainty; Physical parameter; Hot star; Massive stars; Numerical method; Emission line starsRaya prohibida; Observación IR; Observación interferométrica; Modelo; Incertidumbre; Parámetro físico; Estrella caliente; Método numéricoINIST-14176.35400019444638024011-0165741 001692 Transiting exoplanets from the CoRoT space mission: XV. CoRoT-15b: a brown-dwarf transiting companionF. BouchyInstitut d'Astrophysique de Paris, UMR7095 CNRS, Université Pierre & Marie Curie, 98bis Bd Arago75014 ParisFRA1 aut.17 aut.30 aut.Observatoire de Haute Provence, CNRS/OAMP04870 St Michel l'ObservatoireFRA1 aut.M. DeleuilLaboratoire d'Astrophysique de Marseille, 38 rue Frederic Joliot-Curie13388 MarseilleFRA2 aut.11 aut.12 aut.15 aut.24 aut.31 aut.34 aut.38 aut.46 aut.T. GuillotUniversite de Nice-Sophia Antipolis, CNRS UMR 6202, Observatoire de la Côte d'Azur, BP 422906304 NiceFRA3 aut.29 aut.S. AigrainDepartment of Physics, Denys Wilkinson Building Keble RoadOxford, OX1 3RHGBR4 aut.25 aut.L. CaroneRheinisches Institut fur Umweltforschung an der Universitat zu Koln, Aachener Strasse 209Köln 50931DEU5 aut.42 aut.W. D. CochranMcDonald Observatory, The University of TexasAustin, TX 78712USA6 aut.19 aut.36 aut.J. M. AlmenaraInstituto de Astrofosica de Canarias38205 La Laguna, TenerifeESP7 aut.16 aut.41 aut.48 aut.Departamento de Astrofisica, Universidad de La Laguna38200 La Laguna, TenerifeESP7 aut.16 aut.41 aut.48 aut.R. AlonsoObservatoire de l'Université de Genève, 51 chemin des Maillettes1290 SauvernyCHE8 aut.33 aut.43 aut.M. AuvergneLESIA, UMR 8109 CNRS, Observatoire de Paris, UPMC, Université Paris-Diderot, 5 place J. Janssen92195 MeudonFRA9 aut.10 aut.45 aut.A. BaglinLESIA, UMR 8109 CNRS, Observatoire de Paris, UPMC, Université Paris-Diderot, 5 place J. Janssen92195 MeudonFRA9 aut.10 aut.45 aut.P. BargeLaboratoire d'Astrophysique de Marseille, 38 rue Frederic Joliot-Curie13388 MarseilleFRA2 aut.11 aut.12 aut.15 aut.24 aut.31 aut.34 aut.38 aut.46 aut.A. S. BonomoLaboratoire d'Astrophysique de Marseille, 38 rue Frederic Joliot-Curie13388 MarseilleFRA2 aut.11 aut.12 aut.15 aut.24 aut.31 aut.34 aut.38 aut.46 aut.P. BordeInstitut d'Astrophysique Spatiale, Université Paris XI91405 OrsayFRA13 aut.32 aut.40 aut.Sz. CsizmadiaInstitute of Planetary Research, German Aerospace Center, Rutherfordstrasse 212489 BerlinDEU14 aut.20 aut.44 aut.K. De BondtLaboratoire d'Astrophysique de Marseille, 38 rue Frederic Joliot-Curie13388 MarseilleFRA2 aut.11 aut.12 aut.15 aut.24 aut.31 aut.34 aut.38 aut.46 aut.H. J. DeegInstituto de Astrofosica de Canarias38205 La Laguna, TenerifeESP7 aut.16 aut.41 aut.48 aut.Departamento de Astrofisica, Universidad de La Laguna38200 La Laguna, TenerifeESP7 aut.16 aut.41 aut.48 aut.R. F. DiazInstitut d'Astrophysique de Paris, UMR7095 CNRS, Université Pierre & Marie Curie, 98bis Bd Arago75014 ParisFRA1 aut.17 aut.30 aut.R. DvorakUniversity of Vienna, Institute of Astronomy, Türkenschanzstr. 171180 ViennaAUT18 aut.M. EndlMcDonald Observatory, The University of TexasAustin, TX 78712USA6 aut.19 aut.36 aut.A. EriksonInstitute of Planetary Research, German Aerospace Center, Rutherfordstrasse 212489 BerlinDEU14 aut.20 aut.44 aut.S. Ferraz-MelloIAG, University of Sao PauloBRA21 aut.M. FridlundResearch and Scientific Support Department, ESTEC/ESA, PO Box 2992200 AG NoordwijkNLD22 aut.23 aut.D. GandolfiResearch and Scientific Support Department, ESTEC/ESA, PO Box 2992200 AG NoordwijkNLD22 aut.23 aut.Thüringer Landessternwarte, Sternwarte 5, Tautenburg 507778 TautenburgDEU23 aut.27 aut.28 aut.49 aut.J. C. GazzanoLaboratoire d'Astrophysique de Marseille, 38 rue Frederic Joliot-Curie13388 MarseilleFRA2 aut.11 aut.12 aut.15 aut.24 aut.31 aut.34 aut.38 aut.46 aut.N. GibsonDepartment of Physics, Denys Wilkinson Building Keble RoadOxford, OX1 3RHGBR4 aut.25 aut.M. GillonUniversity of Liege, Allée du 6 août 17, Sart TilmanLiegeBEL26 aut.E. GuentherThüringer Landessternwarte, Sternwarte 5, Tautenburg 507778 TautenburgDEU23 aut.27 aut.28 aut.49 aut.A. HazesThüringer Landessternwarte, Sternwarte 5, Tautenburg 507778 TautenburgDEU23 aut.27 aut.28 aut.49 aut.M. HavelUniversite de Nice-Sophia Antipolis, CNRS UMR 6202, Observatoire de la Côte d'Azur, BP 422906304 NiceFRA3 aut.29 aut.G. HebrardInstitut d'Astrophysique de Paris, UMR7095 CNRS, Université Pierre & Marie Curie, 98bis Bd Arago75014 ParisFRA1 aut.17 aut.30 aut.L. JordaLaboratoire d'Astrophysique de Marseille, 38 rue Frederic Joliot-Curie13388 MarseilleFRA2 aut.11 aut.12 aut.15 aut.24 aut.31 aut.34 aut.38 aut.46 aut.A. LegerInstitut d'Astrophysique Spatiale, Université Paris XI91405 OrsayFRA13 aut.32 aut.40 aut.C. LovisObservatoire de l'Université de Genève, 51 chemin des Maillettes1290 SauvernyCHE8 aut.33 aut.43 aut.A. LlebariaLaboratoire d'Astrophysique de Marseille, 38 rue Frederic Joliot-Curie13388 MarseilleFRA2 aut.11 aut.12 aut.15 aut.24 aut.31 aut.34 aut.38 aut.46 aut.H. LammerSpace Research Institute, Austrian Academy of Science, Schmiedlstr. 68042 GrazAUT35 aut.P. J. MacqueenMcDonald Observatory, The University of TexasAustin, TX 78712USA6 aut.19 aut.36 aut.T. MazehSchool of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv UniversityTel AvivISR37 aut.39 aut.C. MoutouLaboratoire d'Astrophysique de Marseille, 38 rue Frederic Joliot-Curie13388 MarseilleFRA2 aut.11 aut.12 aut.15 aut.24 aut.31 aut.34 aut.38 aut.46 aut.A. OfirSchool of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv UniversityTel AvivISR37 aut.39 aut.M. OllivierInstitut d'Astrophysique Spatiale, Université Paris XI91405 OrsayFRA13 aut.32 aut.40 aut.H. ParviainenInstituto de Astrofosica de Canarias38205 La Laguna, TenerifeESP7 aut.16 aut.41 aut.48 aut.Departamento de Astrofisica, Universidad de La Laguna38200 La Laguna, TenerifeESP7 aut.16 aut.41 aut.48 aut.M. P TzoldRheinisches Institut fur Umweltforschung an der Universitat zu Koln, Aachener Strasse 209Köln 50931DEU5 aut.42 aut.D. QuelozObservatoire de l'Université de Genève, 51 chemin des Maillettes1290 SauvernyCHE8 aut.33 aut.43 aut.H. RauerInstitute of Planetary Research, German Aerospace Center, Rutherfordstrasse 212489 BerlinDEU14 aut.20 aut.44 aut.Center for Astronomy and Astrophysics, TU Berlin, Hardenbergstr. 3610623 BerlinDEU44 aut.D. RouanLESIA, UMR 8109 CNRS, Observatoire de Paris, UPMC, Université Paris-Diderot, 5 place J. Janssen92195 MeudonFRA9 aut.10 aut.45 aut.A. SanterneLaboratoire d'Astrophysique de Marseille, 38 rue Frederic Joliot-Curie13388 MarseilleFRA2 aut.11 aut.12 aut.15 aut.24 aut.31 aut.34 aut.38 aut.46 aut.J. SchneiderLUTH, Observatoire de Paris, CNRS, Université Paris Diderot, 5 place Jules Janssen92195 MeudonFRA47 aut.B. TingleyInstituto de Astrofosica de Canarias38205 La Laguna, TenerifeESP7 aut.16 aut.41 aut.48 aut.Departamento de Astrofisica, Universidad de La Laguna38200 La Laguna, TenerifeESP7 aut.16 aut.41 aut.48 aut.G. WuchterlThüringer Landessternwarte, Sternwarte 5, Tautenburg 507778 TautenburgDEU23 aut.27 aut.28 aut.49 aut.11-01657692011PASCAL 11-0165769 INISTPascal:11-01657690012080004-6361Astron. astrophys. : (Berl., Print)Astronomy and astrophysics : (Berlin. Print)Brown dwarf starsCentral starsDwarf starsExtrasolar planetsLight curvesLow-mass starsM starsPlanetary systemRadial velocitySolar type starStandard modelSynchronizationPlanète extrasolaireNaine bruneModèle standardEtoile MEtoile naineEtoile type solaireCourbe lumièreEtoile centraleSynchronisationEtoile faible masseSystème planétaireVitesse radiale
We report the discovery by the CoRoT space mission of a transiting brown dwarf orbiting a F7V star with an orbital period of 3.06 days. CoRoT-15b has a radius of 1.12+0.30-0.15 RJup and a mass of 63.3 ± 4.1 MJup, and is thus the second transiting companion lying in the theoretical mass domain of brown dwarfs. CoRoT-15b is either very young or inflated compared to standard evolution models, a situation similar to that of M-dwarf stars orbiting close to solar-type stars. Spectroscopic constraints and an analysis of the lightcurve imply a spin period in the range 2.9-3.1 days for the central star, which is compatible with a double-synchronisation of the system.
0004-6361AAEJAFAstron. astrophys. : (Berl., Print)525p. 1Transiting exoplanets from the CoRoT space mission: XV. CoRoT-15b: a brown-dwarf transiting companionBOUCHY (F.)DELEUIL (M.)GUILLOT (T.)AIGRAIN (S.)CARONE (L.)COCHRAN (W. D.)ALMENARA (J. M.)ALONSO (R.)AUVERGNE (M.)BAGLIN (A.)BARGE (P.)BONOMO (A. S.)BORDE (P.)CSIZMADIA (Sz.)DE BONDT (K.)DEEG (H. J.)DIAZ (R. F.)DVORAK (R.)ENDL (M.)ERIKSON (A.)FERRAZ-MELLO (S.)FRIDLUND (M.)GANDOLFI (D.)GAZZANO (J. C.)GIBSON (N.)GILLON (M.)GUENTHER (E.)HAZES (A.)HAVEL (M.)HEBRARD (G.)JORDA (L.)LEGER (A.)LOVIS (C.)LLEBARIA (A.)LAMMER (H.)MACQUEEN (P. J.)MAZEH (T.)MOUTOU (C.)OFIR (A.)OLLIVIER (M.)PARVIAINEN (H.)PÄTZOLD (M.)QUELOZ (D.)RAUER (H.)ROUAN (D.)SANTERNE (A.)SCHNEIDER (J.)TINGLEY (B.)WUCHTERL (G.)Institut d'Astrophysique de Paris, UMR7095 CNRS, Université Pierre & Marie Curie, 98bis Bd Arago75014 ParisFRA1 aut.17 aut.30 aut.Observatoire de Haute Provence, CNRS/OAMP04870 St Michel l'ObservatoireFRA1 aut.Laboratoire d'Astrophysique de Marseille, 38 rue Frederic Joliot-Curie13388 MarseilleFRA2 aut.11 aut.12 aut.15 aut.24 aut.31 aut.34 aut.38 aut.46 aut.Universite de Nice-Sophia Antipolis, CNRS UMR 6202, Observatoire de la Côte d'Azur, BP 422906304 NiceFRA3 aut.29 aut.Department of Physics, Denys Wilkinson Building Keble RoadOxford, OX1 3RHGBR4 aut.25 aut.Rheinisches Institut fur Umweltforschung an der Universitat zu Koln, Aachener Strasse 209Köln 50931DEU5 aut.42 aut.McDonald Observatory, The University of TexasAustin, TX 78712USA6 aut.19 aut.36 aut.Instituto de Astrofosica de Canarias38205 La Laguna, TenerifeESP7 aut.16 aut.41 aut.48 aut.Departamento de Astrofisica, Universidad de La Laguna38200 La Laguna, TenerifeESP7 aut.16 aut.41 aut.48 aut.Observatoire de l'Université de Genève, 51 chemin des Maillettes1290 SauvernyCHE8 aut.33 aut.43 aut.LESIA, UMR 8109 CNRS, Observatoire de Paris, UPMC, Université Paris-Diderot, 5 place J. Janssen92195 MeudonFRA9 aut.10 aut.45 aut.Institut d'Astrophysique Spatiale, Université Paris XI91405 OrsayFRA13 aut.32 aut.40 aut.Institute of Planetary Research, German Aerospace Center, Rutherfordstrasse 212489 BerlinDEU14 aut.20 aut.44 aut.University of Vienna, Institute of Astronomy, Türkenschanzstr. 171180 ViennaAUT18 aut.IAG, University of Sao PauloBRA21 aut.Research and Scientific Support Department, ESTEC/ESA, PO Box 2992200 AG NoordwijkNLD22 aut.23 aut.Thüringer Landessternwarte, Sternwarte 5, Tautenburg 507778 TautenburgDEU23 aut.27 aut.28 aut.49 aut.University of Liege, Allée du 6 août 17, Sart TilmanLiegeBEL26 aut.Space Research Institute, Austrian Academy of Science, Schmiedlstr. 68042 GrazAUT35 aut.School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv UniversityTel AvivISR37 aut.39 aut.Center for Astronomy and Astrophysics, TU Berlin, Hardenbergstr. 3610623 BerlinDEU44 aut.LUTH, Observatoire de Paris, CNRS, Université Paris Diderot, 5 place Jules Janssen92195 MeudonFRA47 aut.A68.1-A68.12011ENGINIST141763540001944463806300000© 2011 INIST-CNRS. All rights reserved.1/4 p.11-0165769PAAstronomy and astrophysics : (Berlin. Print)FRAWe report the discovery by the CoRoT space mission of a transiting brown dwarf orbiting a F7V star with an orbital period of 3.06 days. CoRoT-15b has a radius of 1.12+0.30-0.15 RJup and a mass of 63.3 ± 4.1 MJup, and is thus the second transiting companion lying in the theoretical mass domain of brown dwarfs. CoRoT-15b is either very young or inflated compared to standard evolution models, a situation similar to that of M-dwarf stars orbiting close to solar-type stars. Spectroscopic constraints and an analysis of the lightcurve imply a spin period in the range 2.9-3.1 days for the central star, which is compatible with a double-synchronisation of the system.001E03Planète extrasolaire26Extrasolar planets26Naine brune27Brown dwarf stars27Modèle standard28Standard model28Etoile M29M stars29Etoile naine30Dwarf stars30Etoile type solaire31Solar type star31Estrella tipo solar31Courbe lumière32Light curves32Etoile centrale33Central stars33Synchronisation34Synchronization34Etoile faible masse35Low-mass stars35Système planétaire36Planetary system36Sistema planetario36Vitesse radiale37Radial velocity37108OTOOTOPASCAL 11-0165769 INISTTransiting exoplanets from the CoRoT space mission: XV. CoRoT-15b: a brown-dwarf transiting companionBOUCHY (F.); DELEUIL (M.); GUILLOT (T.); AIGRAIN (S.); CARONE (L.); COCHRAN (W. D.); ALMENARA (J. M.); ALONSO (R.); AUVERGNE (M.); BAGLIN (A.); BARGE (P.); BONOMO (A. S.); BORDE (P.); CSIZMADIA (Sz.); DE BONDT (K.); DEEG (H. J.); DIAZ (R. F.); DVORAK (R.); ENDL (M.); ERIKSON (A.); FERRAZ-MELLO (S.); FRIDLUND (M.); GANDOLFI (D.); GAZZANO (J. C.); GIBSON (N.); GILLON (M.); GUENTHER (E.); HAZES (A.); HAVEL (M.); HEBRARD (G.); JORDA (L.); LEGER (A.); LOVIS (C.); LLEBARIA (A.); LAMMER (H.); MACQUEEN (P. J.); MAZEH (T.); MOUTOU (C.); OFIR (A.); OLLIVIER (M.); PARVIAINEN (H.); PÄTZOLD (M.); QUELOZ (D.); RAUER (H.); ROUAN (D.); SANTERNE (A.); SCHNEIDER (J.); TINGLEY (B.); WUCHTERL (G.)Institut d'Astrophysique de Paris, UMR7095 CNRS, Université Pierre & Marie Curie, 98bis Bd Arago/75014 Paris/France (1 aut., 17 aut., 30 aut.); Observatoire de Haute Provence, CNRS/OAMP/04870 St Michel l'Observatoire/France (1 aut.); Laboratoire d'Astrophysique de Marseille, 38 rue Frederic Joliot-Curie/13388 Marseille/France (2 aut., 11 aut., 12 aut., 15 aut., 24 aut., 31 aut., 34 aut., 38 aut., 46 aut.); Universite de Nice-Sophia Antipolis, CNRS UMR 6202, Observatoire de la Côte d'Azur, BP 4229/06304 Nice/France (3 aut., 29 aut.); Department of Physics, Denys Wilkinson Building Keble Road/Oxford, OX1 3RH/Royaume-Uni (4 aut., 25 aut.); Rheinisches Institut fur Umweltforschung an der Universitat zu Koln, Aachener Strasse 209/Köln 50931/Allemagne (5 aut., 42 aut.); McDonald Observatory, The University of Texas/Austin, TX 78712/Etats-Unis (6 aut., 19 aut., 36 aut.); Instituto de Astrofosica de Canarias/38205 La Laguna, Tenerife/Espagne (7 aut., 16 aut., 41 aut., 48 aut.); Departamento de Astrofisica, Universidad de La Laguna/38200 La Laguna, Tenerife/Espagne (7 aut., 16 aut., 41 aut., 48 aut.); Observatoire de l'Université de Genève, 51 chemin des Maillettes/1290 Sauverny/Suisse (8 aut., 33 aut., 43 aut.); LESIA, UMR 8109 CNRS, Observatoire de Paris, UPMC, Université Paris-Diderot, 5 place J. Janssen/92195 Meudon/France (9 aut., 10 aut., 45 aut.); Institut d'Astrophysique Spatiale, Université Paris XI/91405 Orsay/France (13 aut., 32 aut., 40 aut.); Institute of Planetary Research, German Aerospace Center, Rutherfordstrasse 2/12489 Berlin/Allemagne (14 aut., 20 aut., 44 aut.); University of Vienna, Institute of Astronomy, Türkenschanzstr. 17/1180 Vienna/Autriche (18 aut.); IAG, University of Sao Paulo/Brésil (21 aut.); Research and Scientific Support Department, ESTEC/ESA, PO Box 299/2200 AG Noordwijk/Pays-Bas (22 aut., 23 aut.); Thüringer Landessternwarte, Sternwarte 5, Tautenburg 5/07778 Tautenburg/Allemagne (23 aut., 27 aut., 28 aut., 49 aut.); University of Liege, Allée du 6 août 17, Sart Tilman/Liege/Belgique (26 aut.); Space Research Institute, Austrian Academy of Science, Schmiedlstr. 6/8042 Graz/Autriche (35 aut.); School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University/Tel Aviv/Israël (37 aut., 39 aut.); Center for Astronomy and Astrophysics, TU Berlin, Hardenbergstr. 36/10623 Berlin/Allemagne (44 aut.); LUTH, Observatoire de Paris, CNRS, Université Paris Diderot, 5 place Jules Janssen/92195 Meudon/France (47 aut.)
Publication en série; Niveau analytique
Astronomy and astrophysics : (Berlin. Print); ISSN 0004-6361; Coden AAEJAF; France; Da. 2011; Vol. 525; No. p. 1; A68.1-A68.1; Bibl. 1/4 p.AnglaisWe report the discovery by the CoRoT space mission of a transiting brown dwarf orbiting a F7V star with an orbital period of 3.06 days. CoRoT-15b has a radius of 1.12+0.30-0.15 RJup and a mass of 63.3 ± 4.1 MJup, and is thus the second transiting companion lying in the theoretical mass domain of brown dwarfs. CoRoT-15b is either very young or inflated compared to standard evolution models, a situation similar to that of M-dwarf stars orbiting close to solar-type stars. Spectroscopic constraints and an analysis of the lightcurve imply a spin period in the range 2.9-3.1 days for the central star, which is compatible with a double-synchronisation of the system.001E03Planète extrasolaire; Naine brune; Modèle standard; Etoile M; Etoile naine; Etoile type solaire; Courbe lumière; Etoile centrale; Synchronisation; Etoile faible masse; Système planétaire; Vitesse radialeExtrasolar planets; Brown dwarf stars; Standard model; M stars; Dwarf stars; Solar type star; Light curves; Central stars; Synchronization; Low-mass stars; Planetary system; Radial velocityEstrella tipo solar; Sistema planetarioINIST-14176.35400019444638063011-0165769 001693 Probing the Galactic thick disc vertical properties and interfacesD. KatzGEPI, Observatoire de Paris, CNRS, Université Paris Diderot, 5 place Jules Janssen92190 MeudonFRA1 aut.7 aut.C. SoubiranLaboratoire d'Astrophysique de Bordeaux, CNRS - Université Bordeaux 1, 2 rue de l'Observatoire, BP 8933271 FloiracFRA2 aut.R. CayrelGEPI, Observatoire de Paris, CNRS, Université Paris Diderot, 61 avenue de l'Observatoire75014 ParisFRA3 aut.B. BarbuyUniversidade de São Paulo, IAG, Rua do Matão 122605508-900 São PauloBRA4 aut.E. FrielBoston University, 725 Commonwealth AveBoston, MA 02215USA5 aut.O. BienaymeObservatoire de Strasbourg 11, rue de l'Université67000 StrasbourgFRA6 aut.M.-N. PerrinGEPI, Observatoire de Paris, CNRS, Université Paris Diderot, 5 place Jules Janssen92190 MeudonFRA1 aut.7 aut.11-01657912011PASCAL 11-0165791 INISTPascal:11-01657910012070004-6361Astron. astrophys. : (Berl., Print)Astronomy and astrophysics : (Berlin. Print)Absolute magnitudeDisk galaxiesEffective temperatureGalactic disksGalactic planesGravityKinematicsMetallicityNorth galactic poleProper motionSpectroscopical observationStellar abundanceStellar magnitudeStellar spectraVertical gradientDisque galactiqueMétallicitéCinématiquePlan galactiqueMouvement proprePôle galactique nordObservation spectroscopiqueMagnitude stellaireSpectre stellaireTempérature effectiveGravitéMagnitude absolueGradient verticalGalaxies disquesAbondance stellaire
Aims. This work investigates the properties (metallicity and kinematics) and interfaces of the Galactic thick disc as a function of height above the Galactic plane. The main aim is to study the thick disc in a place where it is the main component of the sample. Methods. We take advantage of former astrometric work in two fields of several square degrees in which accurate proper motions were measured down to V-magnitudes of 18.5 in two directions, one near the north galactic pole and the other at a galactic latitude of 46° and galactic longitude near 0°. Spectroscopic observations have been acquired in these two fields for a total of about 400 stars down to magnitude 18.0, at spectral resolutions of 3.5 to 6.25 Å. The spectra have been analysed with the code ETOILE, comparing the target stellar spectra with a grid of 1400 reference stellar spectra. This comparison allowed us to derive the parameters effective temperature, gravity, [Fe/H] and absolute magnitude for each target star. Results. The Metallicity Distribution Function (MDF) of the thin-thick-disc-halo system is derived for several height intervals between 0 and 5 kpc above the Galactic plane. The MDFs show a decrease of the ratio of the thin to thick disc stars between the first and second kilo-parsec. This is consistent with the classical modelling of the vertical density profile of the disc with 2 populations with different scale heights. A vertical metallicity gradient, ∂[Fe/H]/∂z = -0.068 ± 0.009 dexkpc-1, is observed in the thick disc. It is discussed in terms of scenarios of formation of the thick disc.
0004-6361AAEJAFAstron. astrophys. : (Berl., Print)525p. 2Probing the Galactic thick disc vertical properties and interfacesKATZ (D.)SOUBIRAN (C.)CAYREL (R.)BARBUY (B.)FRIEL (E.)BIENAYME (O.)PERRIN (M.-N.)GEPI, Observatoire de Paris, CNRS, Université Paris Diderot, 5 place Jules Janssen92190 MeudonFRA1 aut.7 aut.Laboratoire d'Astrophysique de Bordeaux, CNRS - Université Bordeaux 1, 2 rue de l'Observatoire, BP 8933271 FloiracFRA2 aut.GEPI, Observatoire de Paris, CNRS, Université Paris Diderot, 61 avenue de l'Observatoire75014 ParisFRA3 aut.Universidade de São Paulo, IAG, Rua do Matão 122605508-900 São PauloBRA4 aut.Boston University, 725 Commonwealth AveBoston, MA 02215USA5 aut.Observatoire de Strasbourg 11, rue de l'Université67000 StrasbourgFRA6 aut.A90.1-A90.152011ENGINIST141763540001944464601200000© 2011 INIST-CNRS. All rights reserved.3/4 p.11-0165791PAAstronomy and astrophysics : (Berlin. Print)FRAAims. This work investigates the properties (metallicity and kinematics) and interfaces of the Galactic thick disc as a function of height above the Galactic plane. The main aim is to study the thick disc in a place where it is the main component of the sample. Methods. We take advantage of former astrometric work in two fields of several square degrees in which accurate proper motions were measured down to V-magnitudes of 18.5 in two directions, one near the north galactic pole and the other at a galactic latitude of 46° and galactic longitude near 0°. Spectroscopic observations have been acquired in these two fields for a total of about 400 stars down to magnitude 18.0, at spectral resolutions of 3.5 to 6.25 Å. The spectra have been analysed with the code ETOILE, comparing the target stellar spectra with a grid of 1400 reference stellar spectra. This comparison allowed us to derive the parameters effective temperature, gravity, [Fe/H] and absolute magnitude for each target star. Results. The Metallicity Distribution Function (MDF) of the thin-thick-disc-halo system is derived for several height intervals between 0 and 5 kpc above the Galactic plane. The MDFs show a decrease of the ratio of the thin to thick disc stars between the first and second kilo-parsec. This is consistent with the classical modelling of the vertical density profile of the disc with 2 populations with different scale heights. A vertical metallicity gradient, ∂[Fe/H]/∂z = -0.068 ± 0.009 dexkpc-1, is observed in the thick disc. It is discussed in terms of scenarios of formation of the thick disc.001E03Disque galactique26Galactic disks26Métallicité27Metallicity27Metalicidad27Cinématique28Kinematics28Plan galactique29Galactic planes29Mouvement propre30Proper motion30Pôle galactique nord31North galactic pole31Polo galáctico norte31Observation spectroscopique32Spectroscopical observation32Observación espectroscópica32Magnitude stellaire33Stellar magnitude33Magnitud estelar33Spectre stellaire34Stellar spectra34Température effective35Effective temperature35Gravité36Gravity36Magnitude absolue37Absolute magnitude37Magnitud absoluta37Gradient vertical38Vertical gradient38Gradiente vertical38Galaxies disques39Disk galaxies39Abondance stellaire40Stellar abundance40Abundancia estelar40108OTOOTOPASCAL 11-0165791 INISTProbing the Galactic thick disc vertical properties and interfacesKATZ (D.); SOUBIRAN (C.); CAYREL (R.); BARBUY (B.); FRIEL (E.); BIENAYME (O.); PERRIN (M.-N.)GEPI, Observatoire de Paris, CNRS, Université Paris Diderot, 5 place Jules Janssen/92190 Meudon/France (1 aut., 7 aut.); Laboratoire d'Astrophysique de Bordeaux, CNRS - Université Bordeaux 1, 2 rue de l'Observatoire, BP 89/33271 Floirac/France (2 aut.); GEPI, Observatoire de Paris, CNRS, Université Paris Diderot, 61 avenue de l'Observatoire/75014 Paris/France (3 aut.); Universidade de São Paulo, IAG, Rua do Matão 1226/05508-900 São Paulo/Brésil (4 aut.); Boston University, 725 Commonwealth Ave/Boston, MA 02215/Etats-Unis (5 aut.); Observatoire de Strasbourg 11, rue de l'Université/67000 Strasbourg/France (6 aut.)
Publication en série; Niveau analytique
Astronomy and astrophysics : (Berlin. Print); ISSN 0004-6361; Coden AAEJAF; France; Da. 2011; Vol. 525; No. p. 2; A90.1-A90.15; Bibl. 3/4 p.AnglaisAims. This work investigates the properties (metallicity and kinematics) and interfaces of the Galactic thick disc as a function of height above the Galactic plane. The main aim is to study the thick disc in a place where it is the main component of the sample. Methods. We take advantage of former astrometric work in two fields of several square degrees in which accurate proper motions were measured down to V-magnitudes of 18.5 in two directions, one near the north galactic pole and the other at a galactic latitude of 46° and galactic longitude near 0°. Spectroscopic observations have been acquired in these two fields for a total of about 400 stars down to magnitude 18.0, at spectral resolutions of 3.5 to 6.25 Å. The spectra have been analysed with the code ETOILE, comparing the target stellar spectra with a grid of 1400 reference stellar spectra. This comparison allowed us to derive the parameters effective temperature, gravity, [Fe/H] and absolute magnitude for each target star. Results. The Metallicity Distribution Function (MDF) of the thin-thick-disc-halo system is derived for several height intervals between 0 and 5 kpc above the Galactic plane. The MDFs show a decrease of the ratio of the thin to thick disc stars between the first and second kilo-parsec. This is consistent with the classical modelling of the vertical density profile of the disc with 2 populations with different scale heights. A vertical metallicity gradient, ∂[Fe/H]/∂z = -0.068 ± 0.009 dexkpc-1, is observed in the thick disc. It is discussed in terms of scenarios of formation of the thick disc.001E03Disque galactique; Métallicité; Cinématique; Plan galactique; Mouvement propre; Pôle galactique nord; Observation spectroscopique; Magnitude stellaire; Spectre stellaire; Température effective; Gravité; Magnitude absolue; Gradient vertical; Galaxies disques; Abondance stellaireGalactic disks; Metallicity; Kinematics; Galactic planes; Proper motion; North galactic pole; Spectroscopical observation; Stellar magnitude; Stellar spectra; Effective temperature; Gravity; Absolute magnitude; Vertical gradient; Disk galaxies; Stellar abundanceMetalicidad; Polo galáctico norte; Observación espectroscópica; Magnitud estelar; Magnitud absoluta; Gradiente vertical; Abundancia estelarINIST-14176.35400019444646012011-0165791 001694 Outcomes after related and unrelated umbilical cord blood transplantation for hereditary bone marrow failure syndromes other than Fanconi anemiaRenata BizzettoEurocord, Hospital Saint Louis APHP, IUHParisFRA1 aut.3 aut.13 aut.University of CampinasCampinasBRA1 aut.10 aut.12 aut.Carmen BonfimFederal University of ParanaCuritibaBRA2 aut.9 aut.Vanderson RochaEurocord, Hospital Saint Louis APHP, IUHParisFRA1 aut.3 aut.13 aut.Bone Marrow Transplant Unit, APHP, IUH, Saint Louis HospitalParisFRA3 aut.4 aut.Gérard SocieBone Marrow Transplant Unit, APHP, IUH, Saint Louis HospitalParisFRA3 aut.4 aut.Franco LocatelliIRCCS, Ospedale Bambino Gesu, Rome, University of PaviaITA5 aut.Kawah ChanTexas Transplant Institute and Methodist Children's HospitalTexasUSA6 aut.Oscar RamirezFundacion Clinica Vale del LiliCaliCOL7 aut.Joel SteinSchneider Children's Medical Center of IsraelISR8 aut.Samir NabhanFederal University of ParanaCuritibaBRA2 aut.9 aut.Eliana MirandaUniversity of CampinasCampinasBRA1 aut.10 aut.12 aut.Jakob PasswegUniversity HospitalGenevaCHE11 aut.Carmino Antonio De Souza CaUniversity of CampinasCampinasBRA1 aut.10 aut.12 aut.Eliane GluckmanEurocord, Hospital Saint Louis APHP, IUHParisFRA1 aut.3 aut.13 aut.11-01659312011PASCAL 11-0165931 INISTPascal:11-01659310012060390-6078Haematologica : (Roma)Haematologica : (Roma)AminoaciduriaBlood cellBone marrowBone marrow failureCompatibilityDe Toni-Debré-Fanconi syndromeEngraftmentHLA-SystemHematologyHematopoietic cellHereditaryHomograftMajor histocompatibility systemPrognosisStem cellUmbilical cordUnrelated donorHomogreffePronosticDonneur non apparentéInsuffisance médullaireCordon ombilicalCellule soucheSyndrome de De Toni-Debré-FanconiCellule hématopoïétiqueCellule sanguineMoelle osseuseHéréditairePrise greffeSystème HLASystème histocompatibilité majeurCompatibilitéHématologieAminoacidurieSyndrome de Fanconi
Background Allogeneic stem cell transplantation is the only curative option for patients with hereditary bone marrow failure syndromes. Umbilical cord blood is an alternative source of stem cells for allogeneic transplantation. Design and Methods This multicenter, retrospective study is based on data reported to the Eurocord Registry about patients with hereditary bone marrow failure syndrome who underwent umbilical cord blood transplantation. Results Sixty-four patients with hereditary bone marrow failure syndromes were transplanted from related (n=20) or unrelated donors (n=44). Diagnoses were Diamond-Blackfan anemia (21 patients), congenital amegakaryocytic thrombocytopenia (16 patients), dyskeratosis congenita (8 patients), Shwachman-Diamond syndrome (2 patients), severe congenital neutropenia (16 patients) and unclassified (1 patient). In the group of patients who received grafts from related donors, all patients but one received an HLA-matched sibling transplant. The median number of total nucleated cells infused was 5×107/kg. The cumulative incidence of neutrophil recovery at 60 days was 95%. Two patients had grade II-IV acute graft-versus-host disease, while the 2-year cumulative incidence of chronic graft-versus-host disease was 11 %. The 3-year overall survival rate was 95%. In the group of patients who received grafts from unrelated donors, 86% had HLA-mismatched grafts and three received two umbilical cord blood units. The median number of total nucleated cells infused was 6.1×107/kg. The cumulative incidence of neutrophil recovery at day 60 in this group was 55%. The 100-day cumulative incidence of grade II-IV acute graft-versus-host disease was 24%, while the 2-year cumulative incidence of chronic graft-versus-host disease was 53%. The 3-year overall survival rate was 61 %; better overall survival was associated with age less than 5 years (P=0.01) and 6.1×107/kg or more total nucleated cells infused (P=0.05). Conclusions In patients with hereditary bone marrow failure syndromes, related umbilical cord blood transplantation is associated with excellent outcomes while increasing cell dose and better HLA matching might provide better results in unrelated umbilical cord blood transplantation.
0390-6078Haematologica : (Roma)961Outcomes after related and unrelated umbilical cord blood transplantation for hereditary bone marrow failure syndromes other than Fanconi anemiaBIZZETTO (Renata)BONFIM (Carmen)ROCHA (Vanderson)SOCIE (Gérard)LOCATELLI (Franco)CHAN (Kawah)RAMIREZ (Oscar)STEIN (Joel)NABHAN (Samir)MIRANDA (Eliana)PASSWEG (Jakob)ANTONIO DE SOUZA CA (Carmino)GLUCKMAN (Eliane)Eurocord, Hospital Saint Louis APHP, IUHParisFRA1 aut.3 aut.13 aut.University of CampinasCampinasBRA1 aut.10 aut.12 aut.Federal University of ParanaCuritibaBRA2 aut.9 aut.Bone Marrow Transplant Unit, APHP, IUH, Saint Louis HospitalParisFRA3 aut.4 aut.IRCCS, Ospedale Bambino Gesu, Rome, University of PaviaITA5 aut.Texas Transplant Institute and Methodist Children's HospitalTexasUSA6 aut.Fundacion Clinica Vale del LiliCaliCOL7 aut.Schneider Children's Medical Center of IsraelISR8 aut.University HospitalGenevaCHE11 aut.On behalf of Eurocord and SAA-WP from EBMTAUS134-1412011ENGINIST37183540001944471102100000© 2011 INIST-CNRS. All rights reserved.34 ref.11-0165931PAHaematologica : (Roma)ITABackground Allogeneic stem cell transplantation is the only curative option for patients with hereditary bone marrow failure syndromes. Umbilical cord blood is an alternative source of stem cells for allogeneic transplantation. Design and Methods This multicenter, retrospective study is based on data reported to the Eurocord Registry about patients with hereditary bone marrow failure syndrome who underwent umbilical cord blood transplantation. Results Sixty-four patients with hereditary bone marrow failure syndromes were transplanted from related (n=20) or unrelated donors (n=44). Diagnoses were Diamond-Blackfan anemia (21 patients), congenital amegakaryocytic thrombocytopenia (16 patients), dyskeratosis congenita (8 patients), Shwachman-Diamond syndrome (2 patients), severe congenital neutropenia (16 patients) and unclassified (1 patient). In the group of patients who received grafts from related donors, all patients but one received an HLA-matched sibling transplant. The median number of total nucleated cells infused was 5×107/kg. The cumulative incidence of neutrophil recovery at 60 days was 95%. Two patients had grade II-IV acute graft-versus-host disease, while the 2-year cumulative incidence of chronic graft-versus-host disease was 11 %. The 3-year overall survival rate was 95%. In the group of patients who received grafts from unrelated donors, 86% had HLA-mismatched grafts and three received two umbilical cord blood units. The median number of total nucleated cells infused was 6.1×107/kg. The cumulative incidence of neutrophil recovery at day 60 in this group was 55%. The 100-day cumulative incidence of grade II-IV acute graft-versus-host disease was 24%, while the 2-year cumulative incidence of chronic graft-versus-host disease was 53%. The 3-year overall survival rate was 61 %; better overall survival was associated with age less than 5 years (P=0.01) and 6.1×107/kg or more total nucleated cells infused (P=0.05). Conclusions In patients with hereditary bone marrow failure syndromes, related umbilical cord blood transplantation is associated with excellent outcomes while increasing cell dose and better HLA matching might provide better results in unrelated umbilical cord blood transplantation.002B19D002B14A03Homogreffe01Homograft01Homoinjerto01Pronostic02Prognosis02Pronóstico02Donneur non apparenté03Unrelated donor03Donador no relacionado03Insuffisance médullaireNM04Bone marrow failureNM04Insuficiencia de la médulaNM04Cordon ombilical05Umbilical cord05Cordón umbilical05Cellule souche06Stem cell06Célula primitiva06Syndrome de De Toni-Debré-Fanconi07De Toni-Debré-Fanconi syndrome07De Toni-Debré-Fanconi síndrome07Cellule hématopoïétique08Hematopoietic cell08Célula hematopoyética08Cellule sanguine09Blood cell09Célula sanguínea09Moelle osseuse11Bone marrow11Médula ósea11Héréditaire12Hereditary12Hereditario12Prise greffe17Engraftment17Toma injerto17Système HLA18HLA-System18Sistema HLA18Système histocompatibilité majeur19Major histocompatibility system19Sistema histocompatibilidad mayor19Compatibilité20Compatibility20Compatibilidad20Hématologie21Hematology21Hematología21Aminoacidurie25Aminoaciduria25Aminoaciduria25Syndrome de FanconiINC86Greffe37Graft37Injerto37Hémopathie38Hemopathy38Hemopatía38Aminoacidopathie39Aminoacid disorder39Aminoacido alteración39Pathologie de l'appareil urinaire40Urinary system disease40Aparato urinario patología40Maladie métabolique41Metabolic diseases41Metabolismo patología41Pathologie du rein42Kidney disease42Riñón patología42Tubulopathie43Tubulopathy43Tubulopatía43Enzymopathie45Enzymopathy45Enzimopatía45Maladie héréditaire46Genetic disease46Enfermedad hereditaria46108OTOOTOPASCAL 11-0165931 INISTOutcomes after related and unrelated umbilical cord blood transplantation for hereditary bone marrow failure syndromes other than Fanconi anemiaBIZZETTO (Renata); BONFIM (Carmen); ROCHA (Vanderson); SOCIE (Gérard); LOCATELLI (Franco); CHAN (Kawah); RAMIREZ (Oscar); STEIN (Joel); NABHAN (Samir); MIRANDA (Eliana); PASSWEG (Jakob); ANTONIO DE SOUZA CA (Carmino); GLUCKMAN (Eliane)Eurocord, Hospital Saint Louis APHP, IUH/Paris/France (1 aut., 3 aut., 13 aut.); University of Campinas/Campinas/Brésil (1 aut., 10 aut., 12 aut.); Federal University of Parana/Curitiba/Brésil (2 aut., 9 aut.); Bone Marrow Transplant Unit, APHP, IUH, Saint Louis Hospital/Paris/France (3 aut., 4 aut.); IRCCS, Ospedale Bambino Gesu, Rome, University of Pavia/Italie (5 aut.); Texas Transplant Institute and Methodist Children's Hospital/Texas/Etats-Unis (6 aut.); Fundacion Clinica Vale del Lili/Cali/Colombie (7 aut.); Schneider Children's Medical Center of Israel/Israël (8 aut.); University Hospital/Geneva/Suisse (11 aut.)
Publication en série; Niveau analytique
Haematologica : (Roma); ISSN 0390-6078; Italie; Da. 2011; Vol. 96; No. 1; Pp. 134-141; Bibl. 34 ref.AnglaisBackground Allogeneic stem cell transplantation is the only curative option for patients with hereditary bone marrow failure syndromes. Umbilical cord blood is an alternative source of stem cells for allogeneic transplantation. Design and Methods This multicenter, retrospective study is based on data reported to the Eurocord Registry about patients with hereditary bone marrow failure syndrome who underwent umbilical cord blood transplantation. Results Sixty-four patients with hereditary bone marrow failure syndromes were transplanted from related (n=20) or unrelated donors (n=44). Diagnoses were Diamond-Blackfan anemia (21 patients), congenital amegakaryocytic thrombocytopenia (16 patients), dyskeratosis congenita (8 patients), Shwachman-Diamond syndrome (2 patients), severe congenital neutropenia (16 patients) and unclassified (1 patient). In the group of patients who received grafts from related donors, all patients but one received an HLA-matched sibling transplant. The median number of total nucleated cells infused was 5×107/kg. The cumulative incidence of neutrophil recovery at 60 days was 95%. Two patients had grade II-IV acute graft-versus-host disease, while the 2-year cumulative incidence of chronic graft-versus-host disease was 11 %. The 3-year overall survival rate was 95%. In the group of patients who received grafts from unrelated donors, 86% had HLA-mismatched grafts and three received two umbilical cord blood units. The median number of total nucleated cells infused was 6.1×107/kg. The cumulative incidence of neutrophil recovery at day 60 in this group was 55%. The 100-day cumulative incidence of grade II-IV acute graft-versus-host disease was 24%, while the 2-year cumulative incidence of chronic graft-versus-host disease was 53%. The 3-year overall survival rate was 61 %; better overall survival was associated with age less than 5 years (P=0.01) and 6.1×107/kg or more total nucleated cells infused (P=0.05). Conclusions In patients with hereditary bone marrow failure syndromes, related umbilical cord blood transplantation is associated with excellent outcomes while increasing cell dose and better HLA matching might provide better results in unrelated umbilical cord blood transplantation.002B19D; 002B14A03Homogreffe; Pronostic; Donneur non apparenté; Insuffisance médullaire; Cordon ombilical; Cellule souche; Syndrome de De Toni-Debré-Fanconi; Cellule hématopoïétique; Cellule sanguine; Moelle osseuse; Héréditaire; Prise greffe; Système HLA; Système histocompatibilité majeur; Compatibilité; Hématologie; Aminoacidurie; Syndrome de FanconiGreffe; Hémopathie; Aminoacidopathie; Pathologie de l'appareil urinaire; Maladie métabolique; Pathologie du rein; Tubulopathie; Enzymopathie; Maladie héréditaireHomograft; Prognosis; Unrelated donor; Bone marrow failure; Umbilical cord; Stem cell; De Toni-Debré-Fanconi syndrome; Hematopoietic cell; Blood cell; Bone marrow; Hereditary; Engraftment; HLA-System; Major histocompatibility system; Compatibility; Hematology; AminoaciduriaGraft; Hemopathy; Aminoacid disorder; Urinary system disease; Metabolic diseases; Kidney disease; Tubulopathy; Enzymopathy; Genetic diseaseHomoinjerto; Pronóstico; Donador no relacionado; Insuficiencia de la médula; Cordón umbilical; Célula primitiva; De Toni-Debré-Fanconi síndrome; Célula hematopoyética; Célula sanguínea; Médula ósea; Hereditario; Toma injerto; Sistema HLA; Sistema histocompatibilidad mayor; Compatibilidad; Hematología; AminoaciduriaINIST-3718.35400019444711021011-0165931 001695 Numerical study of tensile tests conducted on systems with elastic-plastic films deposited onto elastic-plastic substratesN. K. FukumasuPolytechnic School, University of Sao PauloSao PauloBRA1 aut.2 aut.4 aut.C. M. AngeloPolytechnic School, University of Sao PauloSao PauloBRA1 aut.2 aut.4 aut.M. IgnatDFI, FCFM, University of ChileSantiagoCHL3 aut.R. M. SouzaPolytechnic School, University of Sao PauloSao PauloBRA1 aut.2 aut.4 aut.11-01666162010PASCAL 11-0166616 INISTPascal:11-01666160012050257-8972Surf. coat. technol.Surface & coatings technologyComputerized simulationElastoplasticityFinite element methodGeometryRupturesStress distributionSurface treatmentsThin filmsElastoplasticitéCouche minceGéométrieMéthode élément finiSimulation ordinateurDistribution contrainteRuptureTraitement surface
In this work, a series of two-dimensional plane-strain finite element analyses was conducted to further understand the stress distribution during tensile tests on coated systems. Besides the film and the substrate, the finite element model also considered a number of cracks perpendicular to the film/substrate interface. Different from analyses commonly found in the literature, the mechanical behavior of both film and substrate was considered elastic-perfectly plastic in part of the analyses. Together with the film yield stress and the number of film cracks, other variables that were considered were crack tip geometry, the distance between two consecutive cracks and the presence of an interlayer. The analysis was based on the normal stresses parallel to the loading axis (σxx), which are responsible for cohesive failures that are observed in the film during this type of test. Results indicated that some configurations studied in this work have significantly reduced the value of σxx at the film/substrate interface and close to the pre-defined crack tips. Furthermore, in all the cases studied the values of σxx were systematically larger at the film/substrate interface than at the film surface.
0257-8972SCTEEJSurf. coat. technol.2055Numerical study of tensile tests conducted on systems with elastic-plastic films deposited onto elastic-plastic substratesProceedings of 37th International Conference on Metallurgical Coatings and Thin Films, ICMCTF 2010, San Diego, California, April 26-April 30, 2010FUKUMASU (N. K.)ANGELO (C. M.)IGNAT (M.)SOUZA (R. M.)ABADIAS (Gregory)ed.MURATORE (Chris)ed.PETROV (Ivan)ed.REBHOLZ (Claus)ed.SCHEIBE (Hans-Joachim)ed.STÜBER (Michael)ed.Polytechnic School, University of Sao PauloSao PauloBRA1 aut.2 aut.4 aut.DFI, FCFM, University of ChileSantiagoCHL3 aut.University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS Bld Marie et Pierre Curie-Teleport 286982 Chasseneuil FuturoscopeFRA1 aut.Materials and Manufactoring Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136 Wright Patterson AFBOH 45433USA2 aut.University of Cyprus Mechanical & Manufactoring Engineering 75 Kallipoleos Street1678 NicosiaCYP4 aut.Fraunhofer IWS Dresden Winterbergstrasse 2801277 DresdenDEU5 aut.Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 176344 Eggenstein-LeopoldshafenDEU6 aut.Advanced Surface Engineering Division (ASED), American Vacuum Society (AVS)USAorg-cong.1415-14192010ENGINIST159873540001936871204100000© 2011 INIST-CNRS. All rights reserved.27 ref.11-0166616PCASurface & coatings technologyNLDIn this work, a series of two-dimensional plane-strain finite element analyses was conducted to further understand the stress distribution during tensile tests on coated systems. Besides the film and the substrate, the finite element model also considered a number of cracks perpendicular to the film/substrate interface. Different from analyses commonly found in the literature, the mechanical behavior of both film and substrate was considered elastic-perfectly plastic in part of the analyses. Together with the film yield stress and the number of film cracks, other variables that were considered were crack tip geometry, the distance between two consecutive cracks and the presence of an interlayer. The analysis was based on the normal stresses parallel to the loading axis (σxx), which are responsible for cohesive failures that are observed in the film during this type of test. Results indicated that some configurations studied in this work have significantly reduced the value of σxx at the film/substrate interface and close to the pre-defined crack tips. Furthermore, in all the cases studied the values of σxx were systematically larger at the film/substrate interface than at the film surface.001B80A65001B80A15001D11G05240Elastoplasticité55Elastoplasticity55Couche mince56Thin films56Géométrie57Geometry57Méthode élément fini58Finite element method58Simulation ordinateur59Computerized simulation59Distribution contrainte60Stress distribution60Rupture61Ruptures61Traitement surface62Surface treatments62Propriété mécanique74Mechanical properties74108OTOOTOInternational Conference on Metallurgical Coatings and Thin Films (ICMCTF)37San Diego USA2010-04-26PASCAL 11-0166616 INISTNumerical study of tensile tests conducted on systems with elastic-plastic films deposited onto elastic-plastic substratesFUKUMASU (N. K.); ANGELO (C. M.); IGNAT (M.); SOUZA (R. M.); ABADIAS (Gregory); MURATORE (Chris); PETROV (Ivan); REBHOLZ (Claus); SCHEIBE (Hans-Joachim); STÜBER (Michael)Polytechnic School, University of Sao Paulo/Sao Paulo/Brésil (1 aut., 2 aut., 4 aut.); DFI, FCFM, University of Chile/Santiago/Chili (3 aut.); University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS Bld Marie et Pierre Curie-Teleport 2/86982 Chasseneuil Futuroscope/France (1 aut.); Materials and Manufactoring Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136 Wright Patterson AFB/OH 45433/Etats-Unis (2 aut.); University of Cyprus Mechanical & Manufactoring Engineering 75 Kallipoleos Street/1678 Nicosia/Chypre (4 aut.); Fraunhofer IWS Dresden Winterbergstrasse 28/01277 Dresden/Allemagne (5 aut.); Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 1/76344 Eggenstein-Leopoldshafen/Allemagne (6 aut.)
Publication en série; Congrès; Niveau analytique
Surface & coatings technology; ISSN 0257-8972; Coden SCTEEJ; Pays-Bas; Da. 2010; Vol. 205; No. 5; Pp. 1415-1419; Bibl. 27 ref.AnglaisIn this work, a series of two-dimensional plane-strain finite element analyses was conducted to further understand the stress distribution during tensile tests on coated systems. Besides the film and the substrate, the finite element model also considered a number of cracks perpendicular to the film/substrate interface. Different from analyses commonly found in the literature, the mechanical behavior of both film and substrate was considered elastic-perfectly plastic in part of the analyses. Together with the film yield stress and the number of film cracks, other variables that were considered were crack tip geometry, the distance between two consecutive cracks and the presence of an interlayer. The analysis was based on the normal stresses parallel to the loading axis (σxx), which are responsible for cohesive failures that are observed in the film during this type of test. Results indicated that some configurations studied in this work have significantly reduced the value of σxx at the film/substrate interface and close to the pre-defined crack tips. Furthermore, in all the cases studied the values of σxx were systematically larger at the film/substrate interface than at the film surface.001B80A65; 001B80A15; 001D11G05; 240Elastoplasticité; Couche mince; Géométrie; Méthode élément fini; Simulation ordinateur; Distribution contrainte; Rupture; Traitement surfacePropriété mécaniqueElastoplasticity; Thin films; Geometry; Finite element method; Computerized simulation; Stress distribution; Ruptures; Surface treatmentsMechanical propertiesINIST-15987.35400019368712041011-0166616 001696 Influence of the nitriding and TiAlN/TiN coating thickness on the sliding wear behavior of duplex treated AISI H13 steelRicardo D. TorresMechanical Engineering Departament, Pontifícia Universidade Católica do ParanáCuritibaBRA1 aut.2 aut.3 aut.Paulo C. Jr SoaresMechanical Engineering Departament, Pontifícia Universidade Católica do ParanáCuritibaBRA1 aut.2 aut.3 aut.Cleomar SchmitzMechanical Engineering Departament, Pontifícia Universidade Católica do ParanáCuritibaBRA1 aut.2 aut.3 aut.Carlos J. M. SiqueiraMechanical Engineering Departament, Universidade Federal do ParanáCuritibaBRA4 aut.11-01666202010PASCAL 11-0166620 INISTPascal:11-01666200012040257-8972Surf. coat. technol.Surface & coatings technologyAluminium nitrideAustenitic ferritic steelDual-phase steelsLayer thicknessMechanical propertiesNitridationNon metal coatingSliding wearStainless steelsSurface treatmentsTitanium nitrideTribologyNitrurationNitrure de titaneNitrure d'aluminiumRevêtement non métalliqueTraitement surfaceEpaisseur coucheTribologieUsure glissementAcier double phaseAcier austénito ferritiqueAcier inoxydablePropriété mécanique
AISI H13 die steel substrates were low pressure gas nitrided to different thicknesses and hardness values. Nitrided and non nitrided samples were subsequently coated with bi-layer TiAlN/TiN to two different thicknesses. The hardness was measured across the coating thickness and observed to be higher when a thinner coating was deposited over nitrided substrates. The hardness behavior across relatively thin (3 μm) coatings was not affected by the nitrided surface hardness or thickness of the nitride layer in the range of values examined here (80-150 μm). On the other hand, the hardness behavior of thicker coatings (8um) was affected by the nitrided layer, as the thicker coatings were soft due to their columnar structure. The specific wear rate of the duplex coatings was affected by the coating thickness and hardness distribution across the coating system.
0257-8972SCTEEJSurf. coat. technol.2055Influence of the nitriding and TiAlN/TiN coating thickness on the sliding wear behavior of duplex treated AISI H13 steelProceedings of 37th International Conference on Metallurgical Coatings and Thin Films, ICMCTF 2010, San Diego, California, April 26-April 30, 2010TORRES (Ricardo D.)SOARES (Paulo C. JR)SCHMITZ (Cleomar)SIQUEIRA (Carlos J. M.)ABADIAS (Gregory)ed.MURATORE (Chris)ed.PETROV (Ivan)ed.REBHOLZ (Claus)ed.SCHEIBE (Hans-Joachim)ed.STÜBER (Michael)ed.Mechanical Engineering Departament, Pontifícia Universidade Católica do ParanáCuritibaBRA1 aut.2 aut.3 aut.Mechanical Engineering Departament, Universidade Federal do ParanáCuritibaBRA4 aut.University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS Bld Marie et Pierre Curie-Teleport 286982 Chasseneuil FuturoscopeFRA1 aut.Materials and Manufactoring Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136 Wright Patterson AFBOH 45433USA2 aut.University of Cyprus Mechanical & Manufactoring Engineering 75 Kallipoleos Street1678 NicosiaCYP4 aut.Fraunhofer IWS Dresden Winterbergstrasse 2801277 DresdenDEU5 aut.Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 176344 Eggenstein-LeopoldshafenDEU6 aut.Advanced Surface Engineering Division (ASED), American Vacuum Society (AVS)USAorg-cong.1381-13852010ENGINIST159873540001936871203500000© 2011 INIST-CNRS. All rights reserved.17 ref.11-0166620PCASurface & coatings technologyNLDAISI H13 die steel substrates were low pressure gas nitrided to different thicknesses and hardness values. Nitrided and non nitrided samples were subsequently coated with bi-layer TiAlN/TiN to two different thicknesses. The hardness was measured across the coating thickness and observed to be higher when a thinner coating was deposited over nitrided substrates. The hardness behavior across relatively thin (3 μm) coatings was not affected by the nitrided surface hardness or thickness of the nitride layer in the range of values examined here (80-150 μm). On the other hand, the hardness behavior of thicker coatings (8um) was affected by the nitrided layer, as the thicker coatings were soft due to their columnar structure. The specific wear rate of the duplex coatings was affected by the coating thickness and hardness distribution across the coating system.001B80A65001D11C06E001D11G001D11C02E240Nitruration55Nitridation55Nitrure de titane56Titanium nitride56Titannitrid56Titanio nitruro56Nitrure d'aluminium57Aluminium nitride57Aluminiumnitrid57Aluminio nitruro57Revêtement non métallique58Non metal coating58Nichtmetallischer Ueberzug58Revestimiento no metálico58Traitement surface59Surface treatments59Epaisseur couche60Layer thickness60Schichtdicke60Espesor capa60Tribologie61Tribology61Usure glissement62Sliding wear62Gleitverschleiss62Desgaste deslizamiento62Acier double phase63Dual-phase steels63Acier austénito ferritique64Austenitic ferritic steel64Austenitisch ferritischer Stahl64Acero ferrítico austenítico64Acier inoxydable65Stainless steels65Propriété mécanique66Mechanical properties66Traitement thermochimique74Thermochemical treatment74Thermochemische Behandlung74Tratamiento termoquímico74108OTOOTOInternational Conference on Metallurgical Coatings and Thin Films (ICMCTF)37San Diego USA2010-04-26PASCAL 11-0166620 INISTInfluence of the nitriding and TiAlN/TiN coating thickness on the sliding wear behavior of duplex treated AISI H13 steelTORRES (Ricardo D.); SOARES (Paulo C. JR); SCHMITZ (Cleomar); SIQUEIRA (Carlos J. M.); ABADIAS (Gregory); MURATORE (Chris); PETROV (Ivan); REBHOLZ (Claus); SCHEIBE (Hans-Joachim); STÜBER (Michael)Mechanical Engineering Departament, Pontifícia Universidade Católica do Paraná/Curitiba/Brésil (1 aut., 2 aut., 3 aut.); Mechanical Engineering Departament, Universidade Federal do Paraná/Curitiba/Brésil (4 aut.); University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS Bld Marie et Pierre Curie-Teleport 2/86982 Chasseneuil Futuroscope/France (1 aut.); Materials and Manufactoring Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136 Wright Patterson AFB/OH 45433/Etats-Unis (2 aut.); University of Cyprus Mechanical & Manufactoring Engineering 75 Kallipoleos Street/1678 Nicosia/Chypre (4 aut.); Fraunhofer IWS Dresden Winterbergstrasse 28/01277 Dresden/Allemagne (5 aut.); Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 1/76344 Eggenstein-Leopoldshafen/Allemagne (6 aut.)
Publication en série; Congrès; Niveau analytique
Surface & coatings technology; ISSN 0257-8972; Coden SCTEEJ; Pays-Bas; Da. 2010; Vol. 205; No. 5; Pp. 1381-1385; Bibl. 17 ref.AnglaisAISI H13 die steel substrates were low pressure gas nitrided to different thicknesses and hardness values. Nitrided and non nitrided samples were subsequently coated with bi-layer TiAlN/TiN to two different thicknesses. The hardness was measured across the coating thickness and observed to be higher when a thinner coating was deposited over nitrided substrates. The hardness behavior across relatively thin (3 μm) coatings was not affected by the nitrided surface hardness or thickness of the nitride layer in the range of values examined here (80-150 μm). On the other hand, the hardness behavior of thicker coatings (8um) was affected by the nitrided layer, as the thicker coatings were soft due to their columnar structure. The specific wear rate of the duplex coatings was affected by the coating thickness and hardness distribution across the coating system.001B80A65; 001D11C06E; 001D11G; 001D11C02E; 240Nitruration; Nitrure de titane; Nitrure d'aluminium; Revêtement non métallique; Traitement surface; Epaisseur couche; Tribologie; Usure glissement; Acier double phase; Acier austénito ferritique; Acier inoxydable; Propriété mécaniqueTraitement thermochimiqueNitridation; Titanium nitride; Aluminium nitride; Non metal coating; Surface treatments; Layer thickness; Tribology; Sliding wear; Dual-phase steels; Austenitic ferritic steel; Stainless steels; Mechanical propertiesThermochemical treatmentTitannitrid; Aluminiumnitrid; Nichtmetallischer Ueberzug; Schichtdicke; Gleitverschleiss; Austenitisch ferritischer StahlTitanio nitruro; Aluminio nitruro; Revestimiento no metálico; Espesor capa; Desgaste deslizamiento; Acero ferrítico austeníticoINIST-15987.35400019368712035011-0166620 001697 Finite element and dimensional analysis algorithm for the prediction of mechanical properties of bulk materials and thin filmsSara Aida Rodriguez PulecioSurface Phenomena Laboratory, Department of Mechanical Engineering, University of São Paulo Av. Prof. Mello Moraes, 223105508-900 Sao Paulo, SPBRA1 aut.2 aut.3 aut.Research Group of Fatigue and Surfaces, Mechanical Engineering School, Universidad del Valle, Cll 13 No100-00 CaliCOL1 aut.Mar A Cristina More FariasSurface Phenomena Laboratory, Department of Mechanical Engineering, University of São Paulo Av. Prof. Mello Moraes, 223105508-900 Sao Paulo, SPBRA1 aut.2 aut.3 aut.Roberto Martins SouzaSurface Phenomena Laboratory, Department of Mechanical Engineering, University of São Paulo Av. Prof. Mello Moraes, 223105508-900 Sao Paulo, SPBRA1 aut.2 aut.3 aut.11-01666312010PASCAL 11-0166631 INISTPascal:11-01666310012030257-8972Surf. coat. technol.Surface & coatings technologyFinite element methodIndentationMechanical propertiesModellingPredictionSurface treatmentsThin filmsVickers testMéthode élément finiModélisationPrédictionPropriété mécaniqueCouche minceEssai VickersIndentationTraitement surface
In this work, the applicability of a new algorithm for the estimation of mechanical properties from instrumented indentation data was studied for thin films. The applicability was analyzed with the aid of both three-dimensional finite element simulations and experimental indentation tests. The numerical approach allowed studying the effect of the substrate on the estimation of mechanical properties of the film, which was conducted based on the ratio hmax/l between maximum indentation depth and film thickness. For the experimental analysis, indentation tests were conducted on AISI H13 tool steel specimens, plasma nitrated and coated with TiN thin films. Results have indicated that, for the conditions analyzed in this work, the elastic deformation of the substrate limited the extraction of mechanical properties of the film/substrate system. This limitation occurred even at low hmax/l ratios and especially for the estimation of the values of yield strength and strain hardening exponent. At indentation depths lower than 4% of the film thickness, the proposed algorithm estimated the mechanical properties of the film with accuracy. Particularly for hardness, precise values were estimated at hmax/l lower than 0.1, i.e. 10% of film thickness.
0257-8972SCTEEJSurf. coat. technol.2055Finite element and dimensional analysis algorithm for the prediction of mechanical properties of bulk materials and thin filmsProceedings of 37th International Conference on Metallurgical Coatings and Thin Films, ICMCTF 2010, San Diego, California, April 26-April 30, 2010RODRIGUEZ PULECIO (Sara Aida)MORE FARIAS (María Cristina)SOUZA (Roberto Martins)ABADIAS (Gregory)ed.MURATORE (Chris)ed.PETROV (Ivan)ed.REBHOLZ (Claus)ed.SCHEIBE (Hans-Joachim)ed.STÜBER (Michael)ed.Surface Phenomena Laboratory, Department of Mechanical Engineering, University of São Paulo Av. Prof. Mello Moraes, 223105508-900 Sao Paulo, SPBRA1 aut.2 aut.3 aut.Research Group of Fatigue and Surfaces, Mechanical Engineering School, Universidad del Valle, Cll 13 No100-00 CaliCOL1 aut.University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS Bld Marie et Pierre Curie-Teleport 286982 Chasseneuil FuturoscopeFRA1 aut.Materials and Manufactoring Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136 Wright Patterson AFBOH 45433USA2 aut.University of Cyprus Mechanical & Manufactoring Engineering 75 Kallipoleos Street1678 NicosiaCYP4 aut.Fraunhofer IWS Dresden Winterbergstrasse 2801277 DresdenDEU5 aut.Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 176344 Eggenstein-LeopoldshafenDEU6 aut.Advanced Surface Engineering Division (ASED), American Vacuum Society (AVS)USAorg-cong.1386-13922010ENGINIST159873540001936871203600000© 2011 INIST-CNRS. All rights reserved.36 ref.11-0166631PCASurface & coatings technologyNLDIn this work, the applicability of a new algorithm for the estimation of mechanical properties from instrumented indentation data was studied for thin films. The applicability was analyzed with the aid of both three-dimensional finite element simulations and experimental indentation tests. The numerical approach allowed studying the effect of the substrate on the estimation of mechanical properties of the film, which was conducted based on the ratio hmax/l between maximum indentation depth and film thickness. For the experimental analysis, indentation tests were conducted on AISI H13 tool steel specimens, plasma nitrated and coated with TiN thin films. Results have indicated that, for the conditions analyzed in this work, the elastic deformation of the substrate limited the extraction of mechanical properties of the film/substrate system. This limitation occurred even at low hmax/l ratios and especially for the estimation of the values of yield strength and strain hardening exponent. At indentation depths lower than 4% of the film thickness, the proposed algorithm estimated the mechanical properties of the film with accuracy. Particularly for hardness, precise values were estimated at hmax/l lower than 0.1, i.e. 10% of film thickness.001B80A65001D11G001B80A15240Méthode élément fini55Finite element method55Modélisation56Modelling56Prédiction57Prediction57Predicción57Propriété mécanique58Mechanical properties58Couche mince59Thin films59Essai Vickers60Vickers test60Vickers Versuch60Ensayo Vickers60Indentation61Indentation61Traitement surface62Surface treatments62108OTOOTOInternational Conference on Metallurgical Coatings and Thin Films (ICMCTF)37San Diego USA2010-04-26PASCAL 11-0166631 INISTFinite element and dimensional analysis algorithm for the prediction of mechanical properties of bulk materials and thin filmsRODRIGUEZ PULECIO (Sara Aida); MORE FARIAS (María Cristina); SOUZA (Roberto Martins); ABADIAS (Gregory); MURATORE (Chris); PETROV (Ivan); REBHOLZ (Claus); SCHEIBE (Hans-Joachim); STÜBER (Michael)Surface Phenomena Laboratory, Department of Mechanical Engineering, University of São Paulo Av. Prof. Mello Moraes, 2231/05508-900 Sao Paulo, SP/Brésil (1 aut., 2 aut., 3 aut.); Research Group of Fatigue and Surfaces, Mechanical Engineering School, Universidad del Valle, Cll 13 No/100-00 Cali/Colombie (1 aut.); University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS Bld Marie et Pierre Curie-Teleport 2/86982 Chasseneuil Futuroscope/France (1 aut.); Materials and Manufactoring Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136 Wright Patterson AFB/OH 45433/Etats-Unis (2 aut.); University of Cyprus Mechanical & Manufactoring Engineering 75 Kallipoleos Street/1678 Nicosia/Chypre (4 aut.); Fraunhofer IWS Dresden Winterbergstrasse 28/01277 Dresden/Allemagne (5 aut.); Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 1/76344 Eggenstein-Leopoldshafen/Allemagne (6 aut.)
Publication en série; Congrès; Niveau analytique
Surface & coatings technology; ISSN 0257-8972; Coden SCTEEJ; Pays-Bas; Da. 2010; Vol. 205; No. 5; Pp. 1386-1392; Bibl. 36 ref.AnglaisIn this work, the applicability of a new algorithm for the estimation of mechanical properties from instrumented indentation data was studied for thin films. The applicability was analyzed with the aid of both three-dimensional finite element simulations and experimental indentation tests. The numerical approach allowed studying the effect of the substrate on the estimation of mechanical properties of the film, which was conducted based on the ratio hmax/l between maximum indentation depth and film thickness. For the experimental analysis, indentation tests were conducted on AISI H13 tool steel specimens, plasma nitrated and coated with TiN thin films. Results have indicated that, for the conditions analyzed in this work, the elastic deformation of the substrate limited the extraction of mechanical properties of the film/substrate system. This limitation occurred even at low hmax/l ratios and especially for the estimation of the values of yield strength and strain hardening exponent. At indentation depths lower than 4% of the film thickness, the proposed algorithm estimated the mechanical properties of the film with accuracy. Particularly for hardness, precise values were estimated at hmax/l lower than 0.1, i.e. 10% of film thickness.001B80A65; 001D11G; 001B80A15; 240Méthode élément fini; Modélisation; Prédiction; Propriété mécanique; Couche mince; Essai Vickers; Indentation; Traitement surfaceFinite element method; Modelling; Prediction; Mechanical properties; Thin films; Vickers test; Indentation; Surface treatmentsVickers VersuchPredicción; Ensayo VickersINIST-15987.35400019368712036011-0166631 001698 Effects of mechanical properties, residual stress and indenter tip geometry on instrumented indentation data in thin filmsCarlos E. K. MadySurface Phenomena Laboratory, Department of Mechanical Engineering, Polytechnic School of the University of São Paulo, Av. Prof. Mello Moraes, 223105508-900, São PauloBRA1 aut.2 aut.3 aut.4 aut.Sara A. RodriguezSurface Phenomena Laboratory, Department of Mechanical Engineering, Polytechnic School of the University of São Paulo, Av. Prof. Mello Moraes, 223105508-900, São PauloBRA1 aut.2 aut.3 aut.4 aut.Research Group of Fatigue and Surface, Mechanical Engineering School, Universidad del Valle, Cll 13 No100-00 CaliCOL2 aut.Adriana G. GomezSurface Phenomena Laboratory, Department of Mechanical Engineering, Polytechnic School of the University of São Paulo, Av. Prof. Mello Moraes, 223105508-900, São PauloBRA1 aut.2 aut.3 aut.4 aut.Roberto M. SouzaSurface Phenomena Laboratory, Department of Mechanical Engineering, Polytechnic School of the University of São Paulo, Av. Prof. Mello Moraes, 223105508-900, São PauloBRA1 aut.2 aut.3 aut.4 aut.11-01666552010PASCAL 11-0166655 INISTPascal:11-01666550012020257-8972Surf. coat. technol.Surface & coatings technologyFinite element methodGeometryIndentationMechanical propertiesMechanical stressModellingResidual stressesSurface treatmentsThin filmsTitanium nitrideContrainte mécaniquePropriété mécaniqueContrainte résiduelleGéométrieIndentationCouche minceNitrure de titaneMéthode élément finiModélisationTraitement surface
In this work, an axisymmetric two-dimensional finite element model was developed to simulate instrumented indentation testing of thin ceramic films deposited onto hard steel substrates. The level of film residual stress (σr), the film elastic modulus (E) and the film work hardening exponent (n) were varied to analyze their effects on indentation data. These numerical results were used to analyze experimental data that were obtained with titanium nitride coated specimens, in which the substrate bias applied during deposition was modified to obtain films with different levels of σr. Good qualitative correlation was obtained when numerical and experimental results were compared, as long as all film properties are considered in the analyses, and not only σr. The numerical analyses were also used to further understand the effect of σr on the mechanical properties calculated based on instrumented indentation data. In this case, the hardness values obtained based on real or calculated contact areas are similar only when sink-in occurs, i.e. with high n or high ratio Y/E, where Y is the yield strength of the film. In an additional analysis, four ratios (R/hmax) between indenter tip radius and maximum penetration depth were simulated to analyze the combined effects of R and σr on the indentation load-displacement curves. In this case, σr did not significantly affect the load curve exponent, which was affected only by the indenter tip radius. On the other hand, the proportional curvature coefficient was significantly affected by σr and n.
0257-8972SCTEEJSurf. coat. technol.2055Effects of mechanical properties, residual stress and indenter tip geometry on instrumented indentation data in thin filmsProceedings of 37th International Conference on Metallurgical Coatings and Thin Films, ICMCTF 2010, San Diego, California, April 26-April 30, 2010MADY (Carlos E. K.)RODRIGUEZ (Sara A.)GOMEZ (Adriana G.)SOUZA (Roberto M.)ABADIAS (Gregory)ed.MURATORE (Chris)ed.PETROV (Ivan)ed.REBHOLZ (Claus)ed.SCHEIBE (Hans-Joachim)ed.STÜBER (Michael)ed.Surface Phenomena Laboratory, Department of Mechanical Engineering, Polytechnic School of the University of São Paulo, Av. Prof. Mello Moraes, 223105508-900, São PauloBRA1 aut.2 aut.3 aut.4 aut.Research Group of Fatigue and Surface, Mechanical Engineering School, Universidad del Valle, Cll 13 No100-00 CaliCOL2 aut.University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS Bld Marie et Pierre Curie-Teleport 286982 Chasseneuil FuturoscopeFRA1 aut.Materials and Manufactoring Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136 Wright Patterson AFBOH 45433USA2 aut.University of Cyprus Mechanical & Manufactoring Engineering 75 Kallipoleos Street1678 NicosiaCYP4 aut.Fraunhofer IWS Dresden Winterbergstrasse 2801277 DresdenDEU5 aut.Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 176344 Eggenstein-LeopoldshafenDEU6 aut.Advanced Surface Engineering Division (ASED), American Vacuum Society (AVS)USAorg-cong.1393-13972010ENGINIST159873540001936871203700000© 2011 INIST-CNRS. All rights reserved.24 ref.11-0166655PCASurface & coatings technologyNLDIn this work, an axisymmetric two-dimensional finite element model was developed to simulate instrumented indentation testing of thin ceramic films deposited onto hard steel substrates. The level of film residual stress (σr), the film elastic modulus (E) and the film work hardening exponent (n) were varied to analyze their effects on indentation data. These numerical results were used to analyze experimental data that were obtained with titanium nitride coated specimens, in which the substrate bias applied during deposition was modified to obtain films with different levels of σr. Good qualitative correlation was obtained when numerical and experimental results were compared, as long as all film properties are considered in the analyses, and not only σr. The numerical analyses were also used to further understand the effect of σr on the mechanical properties calculated based on instrumented indentation data. In this case, the hardness values obtained based on real or calculated contact areas are similar only when sink-in occurs, i.e. with high n or high ratio Y/E, where Y is the yield strength of the film. In an additional analysis, four ratios (R/hmax) between indenter tip radius and maximum penetration depth were simulated to analyze the combined effects of R and σr on the indentation load-displacement curves. In this case, σr did not significantly affect the load curve exponent, which was affected only by the indenter tip radius. On the other hand, the proportional curvature coefficient was significantly affected by σr and n.001B80A65001D11G001B80A15240Contrainte mécanique55Mechanical stress55Mechanische Spannung55Tensión mecánica55Propriété mécanique56Mechanical properties56Contrainte résiduelle57Residual stresses57Géométrie58Geometry58Indentation59Indentation59Couche mince60Thin films60Nitrure de titane61Titanium nitride61Titannitrid61Titanio nitruro61Méthode élément fini62Finite element method62Modélisation63Modelling63Traitement surface64Surface treatments64108OTOOTOInternational Conference on Metallurgical Coatings and Thin Films (ICMCTF)37San Diego USA2010-04-26PASCAL 11-0166655 INISTEffects of mechanical properties, residual stress and indenter tip geometry on instrumented indentation data in thin filmsMADY (Carlos E. K.); RODRIGUEZ (Sara A.); GOMEZ (Adriana G.); SOUZA (Roberto M.); ABADIAS (Gregory); MURATORE (Chris); PETROV (Ivan); REBHOLZ (Claus); SCHEIBE (Hans-Joachim); STÜBER (Michael)Surface Phenomena Laboratory, Department of Mechanical Engineering, Polytechnic School of the University of São Paulo, Av. Prof. Mello Moraes, 2231/05508-900, São Paulo/Brésil (1 aut., 2 aut., 3 aut., 4 aut.); Research Group of Fatigue and Surface, Mechanical Engineering School, Universidad del Valle, Cll 13 No/100-00 Cali/Colombie (2 aut.); University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS Bld Marie et Pierre Curie-Teleport 2/86982 Chasseneuil Futuroscope/France (1 aut.); Materials and Manufactoring Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136 Wright Patterson AFB/OH 45433/Etats-Unis (2 aut.); University of Cyprus Mechanical & Manufactoring Engineering 75 Kallipoleos Street/1678 Nicosia/Chypre (4 aut.); Fraunhofer IWS Dresden Winterbergstrasse 28/01277 Dresden/Allemagne (5 aut.); Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 1/76344 Eggenstein-Leopoldshafen/Allemagne (6 aut.)
Publication en série; Congrès; Niveau analytique
Surface & coatings technology; ISSN 0257-8972; Coden SCTEEJ; Pays-Bas; Da. 2010; Vol. 205; No. 5; Pp. 1393-1397; Bibl. 24 ref.AnglaisIn this work, an axisymmetric two-dimensional finite element model was developed to simulate instrumented indentation testing of thin ceramic films deposited onto hard steel substrates. The level of film residual stress (σr), the film elastic modulus (E) and the film work hardening exponent (n) were varied to analyze their effects on indentation data. These numerical results were used to analyze experimental data that were obtained with titanium nitride coated specimens, in which the substrate bias applied during deposition was modified to obtain films with different levels of σr. Good qualitative correlation was obtained when numerical and experimental results were compared, as long as all film properties are considered in the analyses, and not only σr. The numerical analyses were also used to further understand the effect of σr on the mechanical properties calculated based on instrumented indentation data. In this case, the hardness values obtained based on real or calculated contact areas are similar only when sink-in occurs, i.e. with high n or high ratio Y/E, where Y is the yield strength of the film. In an additional analysis, four ratios (R/hmax) between indenter tip radius and maximum penetration depth were simulated to analyze the combined effects of R and σr on the indentation load-displacement curves. In this case, σr did not significantly affect the load curve exponent, which was affected only by the indenter tip radius. On the other hand, the proportional curvature coefficient was significantly affected by σr and n.001B80A65; 001D11G; 001B80A15; 240Contrainte mécanique; Propriété mécanique; Contrainte résiduelle; Géométrie; Indentation; Couche mince; Nitrure de titane; Méthode élément fini; Modélisation; Traitement surfaceMechanical stress; Mechanical properties; Residual stresses; Geometry; Indentation; Thin films; Titanium nitride; Finite element method; Modelling; Surface treatmentsMechanische Spannung; TitannitridTensión mecánica; Titanio nitruroINIST-15987.35400019368712037011-0166655 001699 Improvement of the cavitation erosion resistance of UNS S31803 stainless steel by duplex treatmentD. H. MesaMetallurgical and Materials Engineering Department of the University of São Paulo, Av. Prof. Mello Moraes 246305508-900 São PauloBRA1 aut.3 aut.Mechanical Technology Program, Technological University of Pereira, Vereda La julitaPereira, RisaraldaCOL1 aut.C. E. PinedoUniversity of Mogi das Cruzes and Heat Tech-Technology for Heat Treatment and Surface Engineering LtdBRA2 aut.A. P. TschiptschinMetallurgical and Materials Engineering Department of the University of São Paulo, Av. Prof. Mello Moraes 246305508-900 São PauloBRA1 aut.3 aut.11-01666652010PASCAL 11-0166665 INISTPascal:11-01666650012010257-8972Surf. coat. technol.Surface & coatings technologyCavitationErosionGrain boundariesMicrostructureNitridationPlasmaStainless steelsSurface treatmentsThermochemical treatmentTribologyWearWear resistanceCavitationTribologieUsureErosionRésistance usureAcier inoxydablePlasmaTraitement thermochimiqueNitrurationJoint grainMicrostructureTraitement surface
A duplex surface treatment consisting of High Temperature Gas Nitriding (HTGN) followed by Low Temperature Plasma Nitriding (LTPN) was carried out in an UNS S31803 duplex stainless steel. The HTGN treatment was intended to produce a relatively thick and hard fully austenitic layer giving mechanical support to the thinner and much harder expanded austenite layer. HTGN was performed at 1200 °C for 3 h, in a 0.1 MPa N2 atmosphere while LTPN, was carried out in a 75% N2 + 25% H2 atmosphere, at 400 °C for 12 h, under a 250 Pa pressure, and 450 V. An expanded austenite γN layer, 2.3 μm thick, 1500 HV0.025 hard, was formed on top of a 100 μm thick, 330 HV 0.1 hard, fully austenitic layer, containing 0.9 wt% N. For comparison purposes LTPN was carried out with UNS S30403 stainless steel specimens obtaining a 4.0 μm thick, 1500 HV 0.025 hard, expanded austenite layer formed on top of a fully austenitic matrix having 190 HV 0.1. The nitrided specimens were tested in a 20 kHz vibratory cavitation-erosion testing equipment. Comparison between the duplex treated UNS S31803 steel and the low temperature plasma nitrided UNS S30403 steel, resulted in incubation times almost 9 times greater. The maximum cavitation wear rate of the LTPN UNS S30403 was 5.5 g/m2h, 180 times greater than the one measured for the duplex treated UNS S31803 steel. The greater cavitation wear resistance of the duplex treated UNS S31803 steel, compared to the LTPN treated UNS S30403 steel was explained by the greater mechanical support the fully austenitic, 330 HV 0.1 hard, 100 μm layer gives to the expanded austenite layer formed on top of the specimen after LTPN. A strong crystallographic textured surface, inherited from the fully austenitic layer formed during HTGN, with the expanded austenite layer showing {101} crystallographic planes//surface contributed also to improve the cavitation resistance o f the duplex treated steel.
0257-8972SCTEEJSurf. coat. technol.2055Improvement of the cavitation erosion resistance of UNS S31803 stainless steel by duplex treatmentProceedings of 37th International Conference on Metallurgical Coatings and Thin Films, ICMCTF 2010, San Diego, California, April 26-April 30, 2010MESA (D. H.)PINEDO (C. E.)TSCHIPTSCHIN (A. P.)ABADIAS (Gregory)ed.MURATORE (Chris)ed.PETROV (Ivan)ed.REBHOLZ (Claus)ed.SCHEIBE (Hans-Joachim)ed.STÜBER (Michael)ed.Metallurgical and Materials Engineering Department of the University of São Paulo, Av. Prof. Mello Moraes 246305508-900 São PauloBRA1 aut.3 aut.Mechanical Technology Program, Technological University of Pereira, Vereda La julitaPereira, RisaraldaCOL1 aut.University of Mogi das Cruzes and Heat Tech-Technology for Heat Treatment and Surface Engineering LtdBRA2 aut.University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS Bld Marie et Pierre Curie-Teleport 286982 Chasseneuil FuturoscopeFRA1 aut.Materials and Manufactoring Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136 Wright Patterson AFBOH 45433USA2 aut.University of Cyprus Mechanical & Manufactoring Engineering 75 Kallipoleos Street1678 NicosiaCYP4 aut.Fraunhofer IWS Dresden Winterbergstrasse 2801277 DresdenDEU5 aut.Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 176344 Eggenstein-LeopoldshafenDEU6 aut.Advanced Surface Engineering Division (ASED), American Vacuum Society (AVS)USAorg-cong.1552-15562010ENGINIST159873540001936871206500000© 2011 INIST-CNRS. All rights reserved.17 ref.11-0166665PCASurface & coatings technologyNLDA duplex surface treatment consisting of High Temperature Gas Nitriding (HTGN) followed by Low Temperature Plasma Nitriding (LTPN) was carried out in an UNS S31803 duplex stainless steel. The HTGN treatment was intended to produce a relatively thick and hard fully austenitic layer giving mechanical support to the thinner and much harder expanded austenite layer. HTGN was performed at 1200 °C for 3 h, in a 0.1 MPa N2 atmosphere while LTPN, was carried out in a 75% N2 + 25% H2 atmosphere, at 400 °C for 12 h, under a 250 Pa pressure, and 450 V. An expanded austenite γN layer, 2.3 μm thick, 1500 HV0.025 hard, was formed on top of a 100 μm thick, 330 HV 0.1 hard, fully austenitic layer, containing 0.9 wt% N. For comparison purposes LTPN was carried out with UNS S30403 stainless steel specimens obtaining a 4.0 μm thick, 1500 HV 0.025 hard, expanded austenite layer formed on top of a fully austenitic matrix having 190 HV 0.1. The nitrided specimens were tested in a 20 kHz vibratory cavitation-erosion testing equipment. Comparison between the duplex treated UNS S31803 steel and the low temperature plasma nitrided UNS S30403 steel, resulted in incubation times almost 9 times greater. The maximum cavitation wear rate of the LTPN UNS S30403 was 5.5 g/m2h, 180 times greater than the one measured for the duplex treated UNS S31803 steel. The greater cavitation wear resistance of the duplex treated UNS S31803 steel, compared to the LTPN treated UNS S30403 steel was explained by the greater mechanical support the fully austenitic, 330 HV 0.1 hard, 100 μm layer gives to the expanded austenite layer formed on top of the specimen after LTPN. A strong crystallographic textured surface, inherited from the fully austenitic layer formed during HTGN, with the expanded austenite layer showing {101} crystallographic planes//surface contributed also to improve the cavitation resistance o f the duplex treated steel.001B80A65001D11G06001D11C02E240Cavitation55Cavitation55Tribologie56Tribology56Usure57Wear57Erosion58Erosion58Résistance usure59Wear resistance59Acier inoxydable60Stainless steels60Plasma61Plasma61Traitement thermochimique62Thermochemical treatment62Thermochemische Behandlung62Tratamiento termoquímico62Nitruration63Nitridation63Joint grain64Grain boundaries64Microstructure65Microstructure65Traitement surface66Surface treatments66Propriété mécanique74Mechanical properties74108OTOOTOInternational Conference on Metallurgical Coatings and Thin Films (ICMCTF)37San Diego USA2010-04-26PASCAL 11-0166665 INISTImprovement of the cavitation erosion resistance of UNS S31803 stainless steel by duplex treatmentMESA (D. H.); PINEDO (C. E.); TSCHIPTSCHIN (A. P.); ABADIAS (Gregory); MURATORE (Chris); PETROV (Ivan); REBHOLZ (Claus); SCHEIBE (Hans-Joachim); STÜBER (Michael)Metallurgical and Materials Engineering Department of the University of São Paulo, Av. Prof. Mello Moraes 2463/05508-900 São Paulo/Brésil (1 aut., 3 aut.); Mechanical Technology Program, Technological University of Pereira, Vereda La julita/Pereira, Risaralda/Colombie (1 aut.); University of Mogi das Cruzes and Heat Tech-Technology for Heat Treatment and Surface Engineering Ltd/Brésil (2 aut.); University of Poitiers - UFR Sciences - SP2MI Laboratoire de Physique des Matériaux (PhyMat) UMR 6630-CNRS Bld Marie et Pierre Curie-Teleport 2/86982 Chasseneuil Futuroscope/France (1 aut.); Materials and Manufactoring Directorate UTC/Air Force Research Laboratory 2941 Hobson Way Room 136 Wright Patterson AFB/OH 45433/Etats-Unis (2 aut.); University of Cyprus Mechanical & Manufactoring Engineering 75 Kallipoleos Street/1678 Nicosia/Chypre (4 aut.); Fraunhofer IWS Dresden Winterbergstrasse 28/01277 Dresden/Allemagne (5 aut.); Karlsruhe Institute of Technology (KIT) Institute for Materials Research I Hermann-von-Helmoltz-Platz 1/76344 Eggenstein-Leopoldshafen/Allemagne (6 aut.)
Publication en série; Congrès; Niveau analytique
Surface & coatings technology; ISSN 0257-8972; Coden SCTEEJ; Pays-Bas; Da. 2010; Vol. 205; No. 5; Pp. 1552-1556; Bibl. 17 ref.AnglaisA duplex surface treatment consisting of High Temperature Gas Nitriding (HTGN) followed by Low Temperature Plasma Nitriding (LTPN) was carried out in an UNS S31803 duplex stainless steel. The HTGN treatment was intended to produce a relatively thick and hard fully austenitic layer giving mechanical support to the thinner and much harder expanded austenite layer. HTGN was performed at 1200 °C for 3 h, in a 0.1 MPa N2 atmosphere while LTPN, was carried out in a 75% N2 + 25% H2 atmosphere, at 400 °C for 12 h, under a 250 Pa pressure, and 450 V. An expanded austenite γN layer, 2.3 μm thick, 1500 HV0.025 hard, was formed on top of a 100 μm thick, 330 HV 0.1 hard, fully austenitic layer, containing 0.9 wt% N. For comparison purposes LTPN was carried out with UNS S30403 stainless steel specimens obtaining a 4.0 μm thick, 1500 HV 0.025 hard, expanded austenite layer formed on top of a fully austenitic matrix having 190 HV 0.1. The nitrided specimens were tested in a 20 kHz vibratory cavitation-erosion testing equipment. Comparison between the duplex treated UNS S31803 steel and the low temperature plasma nitrided UNS S30403 steel, resulted in incubation times almost 9 times greater. The maximum cavitation wear rate of the LTPN UNS S30403 was 5.5 g/m2h, 180 times greater than the one measured for the duplex treated UNS S31803 steel. The greater cavitation wear resistance of the duplex treated UNS S31803 steel, compared to the LTPN treated UNS S30403 steel was explained by the greater mechanical support the fully austenitic, 330 HV 0.1 hard, 100 μm layer gives to the expanded austenite layer formed on top of the specimen after LTPN. A strong crystallographic textured surface, inherited from the fully austenitic layer formed during HTGN, with the expanded austenite layer showing {101} crystallographic planes//surface contributed also to improve the cavitation resistance o f the duplex treated steel.001B80A65; 001D11G06; 001D11C02E; 240Cavitation; Tribologie; Usure; Erosion; Résistance usure; Acier inoxydable; Plasma; Traitement thermochimique; Nitruration; Joint grain; Microstructure; Traitement surfacePropriété mécaniqueCavitation; Tribology; Wear; Erosion; Wear resistance; Stainless steels; Plasma; Thermochemical treatment; Nitridation; Grain boundaries; Microstructure; Surface treatmentsMechanical propertiesThermochemische BehandlungTratamiento termoquímicoINIST-15987.35400019368712065011-0166665