Family load estimates of schizophrenia and associated risk factors in a nation-wide population study of former child and adolescent patients up to forty years of age.
Identifieur interne : 000064 ( PubMed/Corpus ); précédent : 000063; suivant : 000065Family load estimates of schizophrenia and associated risk factors in a nation-wide population study of former child and adolescent patients up to forty years of age.
Auteurs : Dorte Helenius ; Povl Munk-J Rgensen ; Hans-Christoph SteinhausenSource :
- Schizophrenia research [ 1573-2509 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Denmark.
- diagnosis : Schizophrenia.
- epidemiology : Schizophrenia.
- genetics : Schizophrenia.
- Adolescent, Adult, Age of Onset, Chi-Square Distribution, Child, Family Health, Female, Humans, Logistic Models, Longitudinal Studies, Male, Parents, Registries, Risk Factors.
Abstract
This nation-wide register-based study investigates the family load of schizophrenia (SZ) across three generations in affected families compared to control families. Furthermore the study compares the family load in case vs. control families considering the age of onset of the disorder in the cases. In addition, the study addresses the impact of certain socio-demographic risk factors, i.e. sex, region of residence, year of birth, month of birth, and maternal and paternal age at birth.
DOI: 10.1016/j.schres.2012.05.014
PubMed: 22704640
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pubmed:22704640Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Family load estimates of schizophrenia and associated risk factors in a nation-wide population study of former child and adolescent patients up to forty years of age.</title><author><name sortKey="Helenius, Dorte" sort="Helenius, Dorte" uniqKey="Helenius D" first="Dorte" last="Helenius">Dorte Helenius</name><affiliation><nlm:affiliation>Research Unit for Child and Adolescent Psychiatry, Aalborg Psychiatric Hospital, Aarhus University Hospital, Mølleparkvej 10, 9000 Aalborg, Denmark. dorte.helenius@rn.dk</nlm:affiliation></affiliation></author><author><name sortKey="Munk J Rgensen, Povl" sort="Munk J Rgensen, Povl" uniqKey="Munk J Rgensen P" first="Povl" last="Munk-J Rgensen">Povl Munk-J Rgensen</name></author><author><name sortKey="Steinhausen, Hans Christoph" sort="Steinhausen, Hans Christoph" uniqKey="Steinhausen H" first="Hans-Christoph" last="Steinhausen">Hans-Christoph Steinhausen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1016/j.schres.2012.05.014</idno><idno type="RBID">pubmed:22704640</idno><idno type="pmid">22704640</idno><idno type="wicri:Area/PubMed/Corpus">000064</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000064</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Family load estimates of schizophrenia and associated risk factors in a nation-wide population study of former child and adolescent patients up to forty years of age.</title><author><name sortKey="Helenius, Dorte" sort="Helenius, Dorte" uniqKey="Helenius D" first="Dorte" last="Helenius">Dorte Helenius</name><affiliation><nlm:affiliation>Research Unit for Child and Adolescent Psychiatry, Aalborg Psychiatric Hospital, Aarhus University Hospital, Mølleparkvej 10, 9000 Aalborg, Denmark. dorte.helenius@rn.dk</nlm:affiliation></affiliation></author><author><name sortKey="Munk J Rgensen, Povl" sort="Munk J Rgensen, Povl" uniqKey="Munk J Rgensen P" first="Povl" last="Munk-J Rgensen">Povl Munk-J Rgensen</name></author><author><name sortKey="Steinhausen, Hans Christoph" sort="Steinhausen, Hans Christoph" uniqKey="Steinhausen H" first="Hans-Christoph" last="Steinhausen">Hans-Christoph Steinhausen</name></author></analytic><series><title level="j">Schizophrenia research</title><idno type="eISSN">1573-2509</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age of Onset</term><term>Chi-Square Distribution</term><term>Child</term><term>Denmark (epidemiology)</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Longitudinal Studies</term><term>Male</term><term>Parents</term><term>Registries</term><term>Risk Factors</term><term>Schizophrenia (diagnosis)</term><term>Schizophrenia (epidemiology)</term><term>Schizophrenia (genetics)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Denmark</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Schizophrenia</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Schizophrenia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Schizophrenia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age of Onset</term><term>Chi-Square Distribution</term><term>Child</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Longitudinal Studies</term><term>Male</term><term>Parents</term><term>Registries</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This nation-wide register-based study investigates the family load of schizophrenia (SZ) across three generations in affected families compared to control families. Furthermore the study compares the family load in case vs. control families considering the age of onset of the disorder in the cases. In addition, the study addresses the impact of certain socio-demographic risk factors, i.e. sex, region of residence, year of birth, month of birth, and maternal and paternal age at birth.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22704640</PMID><DateCreated><Year>2012</Year><Month>07</Month><Day>10</Day></DateCreated><DateCompleted><Year>2012</Year><Month>12</Month><Day>07</Day></DateCompleted><DateRevised><Year>2016</Year><Month>05</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-2509</ISSN><JournalIssue CitedMedium="Internet"><Volume>139</Volume><Issue>1-3</Issue><PubDate><Year>2012</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Schizophrenia research</Title><ISOAbbreviation>Schizophr. Res.</ISOAbbreviation></Journal><ArticleTitle>Family load estimates of schizophrenia and associated risk factors in a nation-wide population study of former child and adolescent patients up to forty years of age.</ArticleTitle><Pagination><MedlinePgn>183-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.schres.2012.05.014</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">This nation-wide register-based study investigates the family load of schizophrenia (SZ) across three generations in affected families compared to control families. Furthermore the study compares the family load in case vs. control families considering the age of onset of the disorder in the cases. In addition, the study addresses the impact of certain socio-demographic risk factors, i.e. sex, region of residence, year of birth, month of birth, and maternal and paternal age at birth.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">A total of N=2020 child and adolescent psychiatric cases born between 1969 and 1985 registered in the Danish Central Psychiatric Register (DCPR) before the age of 18 developed SZ before the age of 40. N=5982 controls without any psychiatric diagnosis before age 18 were matched for age, sex, and residential region. Psychiatric diagnoses were also obtained on the first-degree relatives, i.e. parents, siblings, and offspring as a part of the Danish Three Generation Study (3GS). A family load was obtained by using various mixed regression models.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">SZ did occur more often in case than in control families. Having a mother, father or a sibling with the disorder was proven to be a risk factor. The year of birth, the region of residence, and paternal age at birth (≥ 35) were associated with SZ. However, the family load was not dependent on age of onset of the case-proband. Furthermore, case relatives did not develop SZ earlier than control relatives.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings based on a very large and representative dataset provide further and solid evidence for the high family aggregation of SZ. The year of birth, the region of residence, and paternal age at birth play an additional role in the development of the disorder.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Helenius</LastName><ForeName>Dorte</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Research Unit for Child and Adolescent Psychiatry, Aalborg Psychiatric Hospital, Aarhus University Hospital, Mølleparkvej 10, 9000 Aalborg, Denmark. dorte.helenius@rn.dk</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Munk-Jørgensen</LastName><ForeName>Povl</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Steinhausen</LastName><ForeName>Hans-Christoph</ForeName><Initials>HC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>06</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Schizophr Res</MedlineTA><NlmUniqueID>8804207</NlmUniqueID><ISSNLinking>0920-9964</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000293">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017668">Age of Onset</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016009">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002648">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D003718">Denmark</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D005192">Family Health</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016015">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008137">Longitudinal Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010290">Parents</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D012042">Registries</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012559">Schizophrenia</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>10</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>4</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>5</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>6</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>6</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>12</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0920-9964(12)00288-5</ArticleId><ArticleId IdType="doi">10.1016/j.schres.2012.05.014</ArticleId><ArticleId IdType="pubmed">22704640</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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