Inorganic Nanoparticles for Photodynamic Therapy.
Identifieur interne : 000017 ( PubMed/Corpus ); précédent : 000016; suivant : 000018Inorganic Nanoparticles for Photodynamic Therapy.
Auteurs : L. Colombeau ; S. Acherar ; F. Baros ; P. Arnoux ; A Mohd Gazzali ; K. Zaghdoudi ; M. Toussaint ; R. Vanderesse ; C. FrochotSource :
- Topics in current chemistry [ 0340-1022 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Inorganic Chemicals.
- chemical , metabolism : Reactive Oxygen Species.
- Humans, Nanoparticles, Photochemotherapy.
Abstract
Photodynamic therapy (PDT) is a well-established technique employed to treat aged macular degeneration and certain types of cancer, or to kill microbes by using a photoactivatable molecule (a photosensitizer, PS) combined with light of an appropriate wavelength and oxygen. Many PSs are used against cancer but none of them are highly specific. Moreover, most are hydrophobic, so are poorly soluble in aqueous media. To improve both the transportation of the compounds and the selectivity of the treatment, nanoparticles (NPs) have been designed. Thanks to their small size, these can accumulate in a tumor because of the well-known enhanced permeability effect. By changing the composition of the nanoparticles it is also possible to achieve other goals, such as (1) targeting receptors that are over-expressed on tumoral cells or neovessels, (2) making them able to absorb two photons (upconversion or biphoton), and (3) improving singlet oxygen generation by the surface plasmon resonance effect (gold nanoparticles). In this chapter we describe recent developments with inorganic NPs in the PDT domain. Pertinent examples selected from the literature are used to illustrate advances in the field. We do not consider either polymeric nanoparticles or quantum dots, as these are developed in other chapters.
DOI: 10.1007/978-3-319-22942-3_4
PubMed: 26589507
Links to Exploration step
pubmed:26589507Le document en format XML
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Baros</name><affiliation><nlm:affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Arnoux, P" sort="Arnoux, P" uniqKey="Arnoux P" first="P" last="Arnoux">P. Arnoux</name><affiliation><nlm:affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gazzali, A Mohd" sort="Gazzali, A Mohd" uniqKey="Gazzali A" first="A Mohd" last="Gazzali">A Mohd Gazzali</name><affiliation><nlm:affiliation>LCPM, UMR CNRS-UL 7375, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zaghdoudi, K" sort="Zaghdoudi, K" uniqKey="Zaghdoudi K" first="K" last="Zaghdoudi">K. Zaghdoudi</name><affiliation><nlm:affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Toussaint, M" sort="Toussaint, M" uniqKey="Toussaint M" first="M" last="Toussaint">M. Toussaint</name><affiliation><nlm:affiliation>CRAN, CNRS UMR-UL 7039, Université de Lorraine, Campus Sciences, BP 70239, 54506, Vandœuvre Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vanderesse, R" sort="Vanderesse, R" uniqKey="Vanderesse R" first="R" last="Vanderesse">R. Vanderesse</name><affiliation><nlm:affiliation>LCPM, UMR CNRS-UL 7375, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Frochot, C" sort="Frochot, C" uniqKey="Frochot C" first="C" last="Frochot">C. Frochot</name><affiliation><nlm:affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France. Celine.frochot@univ-lorraine.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="doi">10.1007/978-3-319-22942-3_4</idno><idno type="RBID">pubmed:26589507</idno><idno type="pmid">26589507</idno><idno type="wicri:Area/PubMed/Corpus">000017</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000017</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inorganic Nanoparticles for Photodynamic Therapy.</title><author><name sortKey="Colombeau, L" sort="Colombeau, L" uniqKey="Colombeau L" first="L" last="Colombeau">L. Colombeau</name><affiliation><nlm:affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Acherar, S" sort="Acherar, S" uniqKey="Acherar S" first="S" last="Acherar">S. Acherar</name><affiliation><nlm:affiliation>LCPM, UMR CNRS-UL 7375, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Baros, F" sort="Baros, F" uniqKey="Baros F" first="F" last="Baros">F. Baros</name><affiliation><nlm:affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Arnoux, P" sort="Arnoux, P" uniqKey="Arnoux P" first="P" last="Arnoux">P. Arnoux</name><affiliation><nlm:affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gazzali, A Mohd" sort="Gazzali, A Mohd" uniqKey="Gazzali A" first="A Mohd" last="Gazzali">A Mohd Gazzali</name><affiliation><nlm:affiliation>LCPM, UMR CNRS-UL 7375, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zaghdoudi, K" sort="Zaghdoudi, K" uniqKey="Zaghdoudi K" first="K" last="Zaghdoudi">K. Zaghdoudi</name><affiliation><nlm:affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Toussaint, M" sort="Toussaint, M" uniqKey="Toussaint M" first="M" last="Toussaint">M. Toussaint</name><affiliation><nlm:affiliation>CRAN, CNRS UMR-UL 7039, Université de Lorraine, Campus Sciences, BP 70239, 54506, Vandœuvre Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vanderesse, R" sort="Vanderesse, R" uniqKey="Vanderesse R" first="R" last="Vanderesse">R. Vanderesse</name><affiliation><nlm:affiliation>LCPM, UMR CNRS-UL 7375, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Frochot, C" sort="Frochot, C" uniqKey="Frochot C" first="C" last="Frochot">C. Frochot</name><affiliation><nlm:affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France. Celine.frochot@univ-lorraine.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Topics in current chemistry</title><idno type="ISSN">0340-1022</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Inorganic Chemicals (administration & dosage)</term><term>Nanoparticles</term><term>Photochemotherapy</term><term>Reactive Oxygen Species (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Inorganic Chemicals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Nanoparticles</term><term>Photochemotherapy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Photodynamic therapy (PDT) is a well-established technique employed to treat aged macular degeneration and certain types of cancer, or to kill microbes by using a photoactivatable molecule (a photosensitizer, PS) combined with light of an appropriate wavelength and oxygen. Many PSs are used against cancer but none of them are highly specific. Moreover, most are hydrophobic, so are poorly soluble in aqueous media. To improve both the transportation of the compounds and the selectivity of the treatment, nanoparticles (NPs) have been designed. Thanks to their small size, these can accumulate in a tumor because of the well-known enhanced permeability effect. By changing the composition of the nanoparticles it is also possible to achieve other goals, such as (1) targeting receptors that are over-expressed on tumoral cells or neovessels, (2) making them able to absorb two photons (upconversion or biphoton), and (3) improving singlet oxygen generation by the surface plasmon resonance effect (gold nanoparticles). In this chapter we describe recent developments with inorganic NPs in the PDT domain. Pertinent examples selected from the literature are used to illustrate advances in the field. We do not consider either polymeric nanoparticles or quantum dots, as these are developed in other chapters.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">26589507</PMID><DateCreated><Year>2015</Year><Month>11</Month><Day>21</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>26</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">0340-1022</ISSN><JournalIssue CitedMedium="Print"><Volume>370</Volume><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Topics in current chemistry</Title><ISOAbbreviation>Top Curr Chem</ISOAbbreviation></Journal><ArticleTitle>Inorganic Nanoparticles for Photodynamic Therapy.</ArticleTitle><Pagination><MedlinePgn>113-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/978-3-319-22942-3_4</ELocationID><Abstract><AbstractText>Photodynamic therapy (PDT) is a well-established technique employed to treat aged macular degeneration and certain types of cancer, or to kill microbes by using a photoactivatable molecule (a photosensitizer, PS) combined with light of an appropriate wavelength and oxygen. Many PSs are used against cancer but none of them are highly specific. Moreover, most are hydrophobic, so are poorly soluble in aqueous media. To improve both the transportation of the compounds and the selectivity of the treatment, nanoparticles (NPs) have been designed. Thanks to their small size, these can accumulate in a tumor because of the well-known enhanced permeability effect. By changing the composition of the nanoparticles it is also possible to achieve other goals, such as (1) targeting receptors that are over-expressed on tumoral cells or neovessels, (2) making them able to absorb two photons (upconversion or biphoton), and (3) improving singlet oxygen generation by the surface plasmon resonance effect (gold nanoparticles). In this chapter we describe recent developments with inorganic NPs in the PDT domain. Pertinent examples selected from the literature are used to illustrate advances in the field. We do not consider either polymeric nanoparticles or quantum dots, as these are developed in other chapters.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Colombeau</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LCPM, UMR CNRS-UL 7375, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Acherar</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>LCPM, UMR CNRS-UL 7375, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baros</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>GDR3049 CNRS "Médicaments Photoactivables - Photochimiothérapie (PHOTOMED)", 31062, Toulouse cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arnoux</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>GDR3049 CNRS "Médicaments Photoactivables - Photochimiothérapie (PHOTOMED)", 31062, Toulouse cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gazzali</LastName><ForeName>A Mohd</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>LCPM, UMR CNRS-UL 7375, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaghdoudi</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LCPM, UMR CNRS-UL 7375, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toussaint</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>CRAN, CNRS UMR-UL 7039, Université de Lorraine, Campus Sciences, BP 70239, 54506, Vandœuvre Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vanderesse</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>LCPM, UMR CNRS-UL 7375, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>GDR3049 CNRS "Médicaments Photoactivables - Photochimiothérapie (PHOTOMED)", 31062, Toulouse cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frochot</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>LRGP, CNRS UMR-UL 7274, Université de Lorraine, ENSIC, 1 rue Grandville, BP 20451, 54001, Nancy Cedex, France. Celine.frochot@univ-lorraine.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>GDR3049 CNRS "Médicaments Photoactivables - Photochimiothérapie (PHOTOMED)", 31062, Toulouse cedex 9, France. Celine.frochot@univ-lorraine.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Top Curr Chem</MedlineTA><NlmUniqueID>0432204</NlmUniqueID><ISSNLinking>0340-1022</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007287">Inorganic Chemicals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007287">Inorganic Chemicals</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000008">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D053758">Nanoparticles</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D010778">Photochemotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017382">Reactive Oxygen Species</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Inorganic nanoparticle</Keyword><Keyword MajorTopicYN="N">Photodynamic therapy</Keyword><Keyword MajorTopicYN="N">Singlet oxygen</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>11</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>11</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1007/978-3-319-22942-3_4</ArticleId><ArticleId IdType="pubmed">26589507</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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