Functionalized silica-based nanoparticles for photodynamic therapy.
Identifieur interne : 000089 ( PubMed/Checkpoint ); précédent : 000088; suivant : 000090Functionalized silica-based nanoparticles for photodynamic therapy.
Auteurs : Pierre Couleaud [France] ; Denise Bechet ; Régis Vanderesse ; Muriel Barberi-Heyob ; Anne-Charlotte Faure ; Stéphane Roux ; Olivier Tillement ; Sabine Porhel ; François Guillemin ; Céline FrochotSource :
- Nanomedicine (London, England) [ 1748-6963 ] ; 2011.
Descripteurs français
- KwdFr :
- Humains, Lignée cellulaire tumorale, Nanoparticules (), Neuropiline 1 (), Peptides (), Peptides (pharmacologie), Peptides (synthèse chimique), Photosensibilisants (), Photosensibilisants (pharmacologie), Photosensibilisants (synthèse chimique), Photothérapie dynamique (), Protéines recombinantes (), Silice (), Structure moléculaire, Survie cellulaire ().
- MESH :
- pharmacologie : Peptides, Photosensibilisants.
- synthèse chimique : Peptides, Photosensibilisants.
- Humains, Lignée cellulaire tumorale, Nanoparticules, Neuropiline 1, Peptides, Photosensibilisants, Photothérapie dynamique, Protéines recombinantes, Silice, Structure moléculaire, Survie cellulaire.
English descriptors
- KwdEn :
- Cell Line, Tumor, Cell Survival (drug effects), Humans, Molecular Structure, Nanoparticles (chemistry), Neuropilin-1 (chemistry), Peptides (chemical synthesis), Peptides (chemistry), Peptides (pharmacology), Photochemotherapy (methods), Photosensitizing Agents (chemical synthesis), Photosensitizing Agents (chemistry), Photosensitizing Agents (pharmacology), Recombinant Proteins (chemistry), Silicon Dioxide (chemistry).
- MESH :
- chemical , chemical synthesis : Peptides, Photosensitizing Agents.
- chemical , chemistry : Neuropilin-1, Peptides, Photosensitizing Agents, Recombinant Proteins, Silicon Dioxide.
- chemistry : Nanoparticles.
- drug effects : Cell Survival.
- methods : Photochemotherapy.
- chemical , pharmacology : Peptides, Photosensitizing Agents.
- Cell Line, Tumor, Humans, Molecular Structure.
Abstract
The strategy developed aims to favor the vascular effect of photodynamic therapy by targeting tumor-associated vascularization using peptide-functionalized nanoparticles. We previously described the conjugation of a photosensitizer to a peptide targeting neuropilin-1 overexpressed in tumor angiogenic vessels.
DOI: 10.2217/nnm.11.31
PubMed: 21726134
Affiliations:
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first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name></author><author><name sortKey="Faure, Anne Charlotte" sort="Faure, Anne Charlotte" uniqKey="Faure A" first="Anne-Charlotte" last="Faure">Anne-Charlotte Faure</name></author><author><name sortKey="Roux, Stephane" sort="Roux, Stephane" uniqKey="Roux S" first="Stéphane" last="Roux">Stéphane Roux</name></author><author><name sortKey="Tillement, Olivier" sort="Tillement, Olivier" uniqKey="Tillement O" first="Olivier" last="Tillement">Olivier Tillement</name></author><author><name sortKey="Porhel, Sabine" sort="Porhel, Sabine" uniqKey="Porhel S" first="Sabine" last="Porhel">Sabine Porhel</name></author><author><name sortKey="Guillemin, Francois" sort="Guillemin, Francois" uniqKey="Guillemin F" first="François" last="Guillemin">François Guillemin</name></author><author><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name></author></analytic><series><title 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()</term><term>Neuropiline 1 ()</term><term>Peptides ()</term><term>Peptides (pharmacologie)</term><term>Peptides (synthèse chimique)</term><term>Photosensibilisants ()</term><term>Photosensibilisants (pharmacologie)</term><term>Photosensibilisants (synthèse chimique)</term><term>Photothérapie dynamique ()</term><term>Protéines recombinantes ()</term><term>Silice ()</term><term>Structure moléculaire</term><term>Survie cellulaire ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Peptides</term><term>Photosensitizing Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Neuropilin-1</term><term>Peptides</term><term>Photosensitizing Agents</term><term>Recombinant Proteins</term><term>Silicon Dioxide</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="drug effects" 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moléculaire</term><term>Survie cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The strategy developed aims to favor the vascular effect of photodynamic therapy by targeting tumor-associated vascularization using peptide-functionalized nanoparticles. We previously described the conjugation of a photosensitizer to a peptide targeting neuropilin-1 overexpressed in tumor angiogenic vessels.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21726134</PMID><DateCreated><Year>2011</Year><Month>09</Month><Day>29</Day></DateCreated><DateCompleted><Year>2012</Year><Month>05</Month><Day>11</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1748-6963</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>6</Issue><PubDate><Year>2011</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Nanomedicine (London, England)</Title><ISOAbbreviation>Nanomedicine (Lond)</ISOAbbreviation></Journal><ArticleTitle>Functionalized silica-based nanoparticles for photodynamic therapy.</ArticleTitle><Pagination><MedlinePgn>995-1009</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2217/nnm.11.31</ELocationID><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">The strategy developed aims to favor the vascular effect of photodynamic therapy by targeting tumor-associated vascularization using peptide-functionalized nanoparticles. We previously described the conjugation of a photosensitizer to a peptide targeting neuropilin-1 overexpressed in tumor angiogenic vessels.</AbstractText><AbstractText Label="MATERIALS & METHODS" NlmCategory="METHODS">In this study, we have designed and photophysically characterized a multifunctional nanoparticle consisting of a surface-localized tumor vasculature targeting peptides and encapsulated photodynamic therapy and imaging agents.</AbstractText><AbstractText Label="RESULTS & CONCLUSION" NlmCategory="CONCLUSIONS">The elaboration of these multifunctional silica-based nanoparticles is reported. Nanoparticles functionalized with approximately 4.2 peptides bound to recombinant neuropilin-1 protein. Nanoparticles conferred photosensitivity to cells overexpressing neuropilin-1, providing evidence that the chlorin grafted within the nanoparticle matrix can be photoactivated to yield photocytotoxic effects in vitro.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Couleaud</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratoire Réactions et Génie des Procédés (LRGP), Nancy-University, CNRS, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bechet</LastName><ForeName>Denise</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Vanderesse</LastName><ForeName>Régis</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Barberi-Heyob</LastName><ForeName>Muriel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Faure</LastName><ForeName>Anne-Charlotte</ForeName><Initials>AC</Initials></Author><Author ValidYN="Y"><LastName>Roux</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Tillement</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Porhel</LastName><ForeName>Sabine</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Guillemin</LastName><ForeName>François</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Frochot</LastName><ForeName>Céline</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>07</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nanomedicine 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Survival</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015394">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D053758">Nanoparticles</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D039942">Neuropilin-1</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010455">Peptides</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000138">chemical synthesis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010778">Photochemotherapy</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017319">Photosensitizing Agents</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000138">chemical synthesis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011994">Recombinant Proteins</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012822">Silicon Dioxide</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>7</Month><Day>4</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>7</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>7</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>5</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.2217/nnm.11.31</ArticleId><ArticleId IdType="pubmed">21726134</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Grand Est</li><li>Lorraine (région)</li></region><settlement><li>Nancy</li></settlement></list><tree><noCountry><name sortKey="Barberi Heyob, Muriel" sort="Barberi Heyob, Muriel" uniqKey="Barberi Heyob M" first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name><name sortKey="Bechet, Denise" sort="Bechet, Denise" uniqKey="Bechet D" first="Denise" last="Bechet">Denise Bechet</name><name sortKey="Faure, Anne Charlotte" sort="Faure, Anne Charlotte" uniqKey="Faure A" first="Anne-Charlotte" last="Faure">Anne-Charlotte Faure</name><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name><name sortKey="Guillemin, Francois" sort="Guillemin, Francois" uniqKey="Guillemin F" first="François" last="Guillemin">François Guillemin</name><name sortKey="Porhel, Sabine" sort="Porhel, Sabine" uniqKey="Porhel S" first="Sabine" last="Porhel">Sabine Porhel</name><name sortKey="Roux, Stephane" sort="Roux, Stephane" uniqKey="Roux S" first="Stéphane" last="Roux">Stéphane Roux</name><name sortKey="Tillement, Olivier" sort="Tillement, Olivier" uniqKey="Tillement O" first="Olivier" last="Tillement">Olivier Tillement</name><name sortKey="Vanderesse, Regis" sort="Vanderesse, Regis" uniqKey="Vanderesse R" first="Régis" last="Vanderesse">Régis Vanderesse</name></noCountry><country name="France"><region name="Grand Est"><name sortKey="Couleaud, Pierre" sort="Couleaud, Pierre" uniqKey="Couleaud P" first="Pierre" last="Couleaud">Pierre Couleaud</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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