LrgpV1, PascalFrancis, Curation, bibRecord, 000329

Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers

Identifieur interne : 000329 ( PascalFrancis/Curation ); précédent : 000328; suivant : 000330

Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers

Auteurs : D. Choguot [France] ; J. L. Six [France] ; M. Leonard [France] ; F. Bouueaux [France] ; C. Vigueron [France] ; E. Dellacherie [France]

Source :

Journal of colloid and interface science [ 0021-9797 ] ; 2003.

RBID : Pascal:04-0047642

Descripteurs français

Pascal (Inist)
- Copolymère biséquencé, Lactique acide copolymère, Ethylène oxyde copolymère, Tension superficielle, Solution aqueuse, Agent surface non ionique, Stabilisant, Emulsion huile eau, Effet composition, Préparation, Lactique acide polymère, Nanosphère.

English descriptors

KwdEn :
- Aqueous solution, Composition effect, Diblock copolymer, Ethylene oxide copolymer, Lactic acid copolymer, Lactic acid polymer, Nanosphere, Non ionic surfactant, Oil water emulsion, Preparation, Stabilizer agent, Surface tension.

Abstract

Different water-soluble MPEO-PLA diblock copolymers with various α-methoxy-ω-hydroxyl polyethylene (MPEO) and poly(lactic acid) (PLA) block lengths have been synthesized. Their surface-active properties were evidenced by surface tension (water/air) measurements. In each case the surface tension leveled down above a critical polymer concentration, which was attributed to the formation of a dense polymer layer at the liquid-air interface. The applicability of copolymers as emulsion stabilizers in the preparation of PLA nanospheres by an o/w emulsion/evaporation technique was then investigated. Four copolymers presenting sufficient water solubility and good surfactive properties were used to prepare PLA nanospheres with MPEO chains firmly anchored at the particle surface. The effect of polymer concentration in emulsion on particle size and surface coverage was examined. Whatever the copolymer characteristics, it was found that the optimal concentration to obtain a large amount of MPEO at the particle surface was similar (around 2 g/l). The effect of the copolymer composition on MPEO layer characteristics and on colloidal stability was also evaluated. The conformation of MPEO blocks at the PLA particle surface is discussed in relation to the layer thickness and the surface area occupied per molecule.

A01	`01`	`1`		`@0 0021-9797`
A02	`01`			`@0 JCISA5`
A03		`1`		`@0 J. colloid interface sci.`
A05				`@2 268`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers`
A11	`01`	`1`		`@1 CHOGUOT (D.)`
A11	`02`	`1`		`@1 SIX (J. L.)`
A11	`03`	`1`		`@1 LEONARD (M.)`
A11	`04`	`1`		`@1 BOUUEAUX (F.)`
A11	`05`	`1`		`@1 VIGUERON (C.)`
A11	`06`	`1`		`@1 DELLACHERIE (E.)`
A14	`01`			`@1 Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS-INPL 7568, Groupe ENSIC, BP 451 @2 54001 Nancy @3 FRA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 6 aut.`
A14	`02`			`@1 Laboratoire d'Hématologie-Physiologie, Faculté de Pharmacie, 5, rue Albert Lebrun @2 54000 Nancy @3 FRA @Z 4 aut. @Z 5 aut.`
A20				`@1 441-447`
A21				`@1 2003`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 4124 @5 354000118862320190`
A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
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A64	`01`	`1`		`@0 Journal of colloid and interface science`
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C01	`01`		`ENG`	@0 Different water-soluble MPEO-PLA diblock copolymers with various α-methoxy-ω-hydroxyl polyethylene (MPEO) and poly(lactic acid) (PLA) block lengths have been synthesized. Their surface-active properties were evidenced by surface tension (water/air) measurements. In each case the surface tension leveled down above a critical polymer concentration, which was attributed to the formation of a dense polymer layer at the liquid-air interface. The applicability of copolymers as emulsion stabilizers in the preparation of PLA nanospheres by an o/w emulsion/evaporation technique was then investigated. Four copolymers presenting sufficient water solubility and good surfactive properties were used to prepare PLA nanospheres with MPEO chains firmly anchored at the particle surface. The effect of polymer concentration in emulsion on particle size and surface coverage was examined. Whatever the copolymer characteristics, it was found that the optimal concentration to obtain a large amount of MPEO at the particle surface was similar (around 2 g/l). The effect of the copolymer composition on MPEO layer characteristics and on colloidal stability was also evaluated. The conformation of MPEO blocks at the PLA particle surface is discussed in relation to the layer thickness and the surface area occupied per molecule.
C02	`01`	`X`		`@0 001C01J02`
C03	`01`	`X`	`FRE`	`@0 Copolymère biséquencé @2 NK @5 01`
C03	`01`	`X`	`ENG`	`@0 Diblock copolymer @2 NK @5 01`
C03	`01`	`X`	`SPA`	`@0 Copolímero bisecuencia @2 NK @5 01`
C03	`02`	`X`	`FRE`	`@0 Lactique acide copolymère @2 NK @5 02`
C03	`02`	`X`	`ENG`	`@0 Lactic acid copolymer @2 NK @5 02`
C03	`02`	`X`	`SPA`	`@0 Láctico ácido copolímero @2 NK @5 02`
C03	`03`	`X`	`FRE`	`@0 Ethylène oxyde copolymère @2 NK @5 03`
C03	`03`	`X`	`ENG`	`@0 Ethylene oxide copolymer @2 NK @5 03`
C03	`03`	`X`	`SPA`	`@0 Etileno óxido copolímero @2 NK @5 03`
C03	`04`	`X`	`FRE`	`@0 Tension superficielle @5 05`
C03	`04`	`X`	`ENG`	`@0 Surface tension @5 05`
C03	`04`	`X`	`SPA`	`@0 Tensión superficial @5 05`
C03	`05`	`X`	`FRE`	`@0 Solution aqueuse @5 06`
C03	`05`	`X`	`ENG`	`@0 Aqueous solution @5 06`
C03	`05`	`X`	`SPA`	`@0 Solución acuosa @5 06`
C03	`06`	`X`	`FRE`	`@0 Agent surface non ionique @5 07`
C03	`06`	`X`	`ENG`	`@0 Non ionic surfactant @5 07`
C03	`06`	`X`	`SPA`	`@0 Agente superficie no iónica @5 07`
C03	`07`	`X`	`FRE`	`@0 Stabilisant @5 08`
C03	`07`	`X`	`ENG`	`@0 Stabilizer agent @5 08`
C03	`07`	`X`	`SPA`	`@0 Estabilizante @5 08`
C03	`08`	`X`	`FRE`	`@0 Emulsion huile eau @5 09`
C03	`08`	`X`	`ENG`	`@0 Oil water emulsion @5 09`
C03	`08`	`X`	`SPA`	`@0 Emulsión aceite agua @5 09`
C03	`09`	`X`	`FRE`	`@0 Effet composition @5 10`
C03	`09`	`X`	`ENG`	`@0 Composition effect @5 10`
C03	`09`	`X`	`SPA`	`@0 Efecto composición @5 10`
C03	`10`	`X`	`FRE`	`@0 Préparation @5 11`
C03	`10`	`X`	`ENG`	`@0 Preparation @5 11`
C03	`10`	`X`	`SPA`	`@0 Preparación @5 11`
C03	`11`	`X`	`FRE`	`@0 Lactique acide polymère @2 NK @5 12`
C03	`11`	`X`	`ENG`	`@0 Lactic acid polymer @2 NK @5 12`
C03	`11`	`X`	`SPA`	`@0 Láctico ácido polímero @2 NK @5 12`
C03	`12`	`X`	`FRE`	`@0 Nanosphère @5 13`
C03	`12`	`X`	`ENG`	`@0 Nanosphere @5 13`
C03	`12`	`X`	`SPA`	`@0 Nanosfera @5 13`
C07	`01`	`X`	`FRE`	`@0 Propriété surface @5 04`
C07	`01`	`X`	`ENG`	`@0 Surface properties @5 04`
C07	`01`	`X`	`SPA`	`@0 Propiedad superficie @5 04`
N21				`@1 033`
N82				`@1 PSI`

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Different water-soluble MPEO-PLA diblock copolymers with various α-methoxy-ω-hydroxyl polyethylene (MPEO) and poly(lactic acid) (PLA) block lengths have been synthesized. Their surface-active properties were evidenced by surface tension (water/air) measurements. In each case the surface tension leveled down above a critical polymer concentration, which was attributed to the formation of a dense polymer layer at the liquid-air interface. The applicability of copolymers as emulsion stabilizers in the preparation of PLA nanospheres by an o/w emulsion/evaporation technique was then investigated. Four copolymers presenting sufficient water solubility and good surfactive properties were used to prepare PLA nanospheres with MPEO chains firmly anchored at the particle surface. The effect of polymer concentration in emulsion on particle size and surface coverage was examined. Whatever the copolymer characteristics, it was found that the optimal concentration to obtain a large amount of MPEO at the particle surface was similar (around 2 g/l). The effect of the copolymer composition on MPEO layer characteristics and on colloidal stability was also evaluated. The conformation of MPEO blocks at the PLA particle surface is discussed in relation to the layer thickness and the surface area occupied per molecule.</div>
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<fC01 i1="01" l="ENG"><s0>Different water-soluble MPEO-PLA diblock copolymers with various α-methoxy-ω-hydroxyl polyethylene (MPEO) and poly(lactic acid) (PLA) block lengths have been synthesized. Their surface-active properties were evidenced by surface tension (water/air) measurements. In each case the surface tension leveled down above a critical polymer concentration, which was attributed to the formation of a dense polymer layer at the liquid-air interface. The applicability of copolymers as emulsion stabilizers in the preparation of PLA nanospheres by an o/w emulsion/evaporation technique was then investigated. Four copolymers presenting sufficient water solubility and good surfactive properties were used to prepare PLA nanospheres with MPEO chains firmly anchored at the particle surface. The effect of polymer concentration in emulsion on particle size and surface coverage was examined. Whatever the copolymer characteristics, it was found that the optimal concentration to obtain a large amount of MPEO at the particle surface was similar (around 2 g/l). The effect of the copolymer composition on MPEO layer characteristics and on colloidal stability was also evaluated. The conformation of MPEO blocks at the PLA particle surface is discussed in relation to the layer thickness and the surface area occupied per molecule.</s0>
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<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Ethylene oxide copolymer</s0>
<s2>NK</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Etileno óxido copolímero</s0>
<s2>NK</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Tension superficielle</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Surface tension</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Tensión superficial</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Solution aqueuse</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Aqueous solution</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Solución acuosa</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Agent surface non ionique</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Non ionic surfactant</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Agente superficie no iónica</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Stabilisant</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Stabilizer agent</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Estabilizante</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Emulsion huile eau</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Oil water emulsion</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Emulsión aceite agua</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Effet composition</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Composition effect</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Efecto composición</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Préparation</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Preparation</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Preparación</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Lactique acide polymère</s0>
<s2>NK</s2>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Lactic acid polymer</s0>
<s2>NK</s2>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Láctico ácido polímero</s0>
<s2>NK</s2>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Nanosphère</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Nanosphere</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Nanosfera</s0>
<s5>13</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Propriété surface</s0>
<s5>04</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Surface properties</s0>
<s5>04</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Propiedad superficie</s0>
<s5>04</s5>
</fC07>
<fN21><s1>033</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers

Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers

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