LrgpV1, PascalFrancis, Corpus, bibRecord, 000238

Biological activities of flavonoids from Nitraria retusa (Forssk.) Asch. and their acylated derivatives

Identifieur interne : 000238 ( PascalFrancis/Corpus ); précédent : 000237; suivant : 000239

Biological activities of flavonoids from Nitraria retusa (Forssk.) Asch. and their acylated derivatives

Auteurs : Jamila Hadj Salem ; Isabelle Chevalot ; Christelle Harscoat-Schiavo ; Cédric Paris ; Michel Fick ; Catherine Humeau

Source :

Food chemistry [ 0308-8146 ] ; 2010.

RBID : Pascal:10-0460265

Descripteurs français

Pascal (Inist)
- Activité biologique, Flavonoïde, Réaction enzymatique, Acylation, Ester, Antioxydant, Anticancéreux.

English descriptors

KwdEn :
- Acylation, Antineoplastic agent, Antioxidant, Biological activity, Enzymatic reaction, Ester, Flavonoid.

Abstract

The antioxidant activity and antiproliferative property towards Caco2 cells of water and methanol extracts/fractions of Nitraria retusa were investigated. The total phenolic and flavonoid contents of the extracts/fractions were determined, and the four major flavonoids were identified as isorhamnetin, isorhamnetin-3-0-glucoside, isorhamnetin-3-O-rutinoside and isorhamnetin-3-O-robinobioside. The results showed a relationship between the extracts/fractions activities and their flavonoid contents. Moreover, the chloroform extract which was enriched with the aglycone flavonoid isorhamnetin exhibited the highest activities. The activities of N. retusa flavonoids were compared to those of model flavonoids, quercetin, isoquercitrin and rutin. In all cases, the aglycone compounds were more active than their glycosylated derivatives. Isorhamnetin-based flavonoids presented higher antiproliferative activities than quercetin-based ones, while similar antioxidant properties were observed. The enzymatic acylation of isorhamnetin-3-O-glucoside with ethyl laurate and ethyl butyrate enhanced its capacity to inhibit xanthine oxidase and its antiproliferative activity but decreased its radical scavenging activity.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0308-8146`
A02	`01`			`@0 FOCHDJ`
A03		`1`		`@0 Food chem.`
A05				`@2 124`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Biological activities of flavonoids from Nitraria retusa (Forssk.) Asch. and their acylated derivatives`
A11	`01`	`1`		`@1 HADJ SALEM (Jamila)`
A11	`02`	`1`		`@1 CHEVALOT (Isabelle)`
A11	`03`	`1`		`@1 HARSCOAT-SCHIAVO (Christelle)`
A11	`04`	`1`		`@1 PARIS (Cédric)`
A11	`05`	`1`		`@1 FICK (Michel)`
A11	`06`	`1`		`@1 HUMEAU (Catherine)`
A14	`01`			`@1 LRGP, Nancy Université, CNRS, 2 avenue de la forêt de Haye @2 54500 Vandoeuvre-lès-Nancy @3 FRA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut.`
A14	`02`			`@1 LIBIO. Nancy Université, 2 avenue de la forêt de Haye @2 54500 Vandoeuvre-lès-Nancy @3 FRA @Z 4 aut. @Z 6 aut.`
A20				`@1 486-494`
A21				`@1 2010`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 17810 @5 354000192678640110`
A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 3/4 p.`
A47	`01`	`1`		`@0 10-0460265`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Food chemistry`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 The antioxidant activity and antiproliferative property towards Caco2 cells of water and methanol extracts/fractions of Nitraria retusa were investigated. The total phenolic and flavonoid contents of the extracts/fractions were determined, and the four major flavonoids were identified as isorhamnetin, isorhamnetin-3-0-glucoside, isorhamnetin-3-O-rutinoside and isorhamnetin-3-O-robinobioside. The results showed a relationship between the extracts/fractions activities and their flavonoid contents. Moreover, the chloroform extract which was enriched with the aglycone flavonoid isorhamnetin exhibited the highest activities. The activities of N. retusa flavonoids were compared to those of model flavonoids, quercetin, isoquercitrin and rutin. In all cases, the aglycone compounds were more active than their glycosylated derivatives. Isorhamnetin-based flavonoids presented higher antiproliferative activities than quercetin-based ones, while similar antioxidant properties were observed. The enzymatic acylation of isorhamnetin-3-O-glucoside with ethyl laurate and ethyl butyrate enhanced its capacity to inhibit xanthine oxidase and its antiproliferative activity but decreased its radical scavenging activity.
C02	`01`	`X`		`@0 002A35`
C03	`01`	`X`	`FRE`	`@0 Activité biologique @5 01`
C03	`01`	`X`	`ENG`	`@0 Biological activity @5 01`
C03	`01`	`X`	`SPA`	`@0 Actividad biológica @5 01`
C03	`02`	`X`	`FRE`	`@0 Flavonoïde @5 02`
C03	`02`	`X`	`ENG`	`@0 Flavonoid @5 02`
C03	`02`	`X`	`SPA`	`@0 Flavonoide @5 02`
C03	`03`	`X`	`FRE`	`@0 Réaction enzymatique @5 10`
C03	`03`	`X`	`ENG`	`@0 Enzymatic reaction @5 10`
C03	`03`	`X`	`SPA`	`@0 Reacción enzimática @5 10`
C03	`04`	`X`	`FRE`	`@0 Acylation @5 19`
C03	`04`	`X`	`ENG`	`@0 Acylation @5 19`
C03	`04`	`X`	`SPA`	`@0 Acilación @5 19`
C03	`05`	`X`	`FRE`	`@0 Ester @5 20`
C03	`05`	`X`	`ENG`	`@0 Ester @5 20`
C03	`05`	`X`	`SPA`	`@0 Ester @5 20`
C03	`06`	`X`	`FRE`	`@0 Antioxydant @5 24`
C03	`06`	`X`	`ENG`	`@0 Antioxidant @5 24`
C03	`06`	`X`	`SPA`	`@0 Antioxidante @5 24`
C03	`07`	`X`	`FRE`	`@0 Anticancéreux @5 26`
C03	`07`	`X`	`ENG`	`@0 Antineoplastic agent @5 26`
C03	`07`	`X`	`SPA`	`@0 Anticanceroso @5 26`
C07	`01`	`X`	`FRE`	`@0 Polyphénol @5 08`
C07	`01`	`X`	`ENG`	`@0 Polyphenol @5 08`
C07	`01`	`X`	`SPA`	`@0 Polifenol @5 08`
N21				`@1 298`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0460265 INIST
ET :	Biological activities of flavonoids from Nitraria retusa (Forssk.) Asch. and their acylated derivatives
AU :	HADJ SALEM (Jamila); CHEVALOT (Isabelle); HARSCOAT-SCHIAVO (Christelle); PARIS (Cédric); FICK (Michel); HUMEAU (Catherine)
AF :	LRGP, Nancy Université, CNRS, 2 avenue de la forêt de Haye/54500 Vandoeuvre-lès-Nancy/France (1 aut., 2 aut., 3 aut., 5 aut.); LIBIO. Nancy Université, 2 avenue de la forêt de Haye/54500 Vandoeuvre-lès-Nancy/France (4 aut., 6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Food chemistry; ISSN 0308-8146; Coden FOCHDJ; Royaume-Uni; Da. 2010; Vol. 124; No. 2; Pp. 486-494; Bibl. 3/4 p.
LA :	Anglais
EA :	The antioxidant activity and antiproliferative property towards Caco2 cells of water and methanol extracts/fractions of Nitraria retusa were investigated. The total phenolic and flavonoid contents of the extracts/fractions were determined, and the four major flavonoids were identified as isorhamnetin, isorhamnetin-3-0-glucoside, isorhamnetin-3-O-rutinoside and isorhamnetin-3-O-robinobioside. The results showed a relationship between the extracts/fractions activities and their flavonoid contents. Moreover, the chloroform extract which was enriched with the aglycone flavonoid isorhamnetin exhibited the highest activities. The activities of N. retusa flavonoids were compared to those of model flavonoids, quercetin, isoquercitrin and rutin. In all cases, the aglycone compounds were more active than their glycosylated derivatives. Isorhamnetin-based flavonoids presented higher antiproliferative activities than quercetin-based ones, while similar antioxidant properties were observed. The enzymatic acylation of isorhamnetin-3-O-glucoside with ethyl laurate and ethyl butyrate enhanced its capacity to inhibit xanthine oxidase and its antiproliferative activity but decreased its radical scavenging activity.
CC :	002A35
FD :	Activité biologique; Flavonoïde; Réaction enzymatique; Acylation; Ester; Antioxydant; Anticancéreux
FG :	Polyphénol
ED :	Biological activity; Flavonoid; Enzymatic reaction; Acylation; Ester; Antioxidant; Antineoplastic agent
EG :	Polyphenol
SD :	Actividad biológica; Flavonoide; Reacción enzimática; Acilación; Ester; Antioxidante; Anticanceroso
LO :	INIST-17810.354000192678640110
ID :	10-0460265

Links to Exploration step

Pascal:10-0460265

Le document en format XML

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<front><div type="abstract" xml:lang="en">The antioxidant activity and antiproliferative property towards Caco2 cells of water and methanol extracts/fractions of Nitraria retusa were investigated. The total phenolic and flavonoid contents of the extracts/fractions were determined, and the four major flavonoids were identified as isorhamnetin, isorhamnetin-3-0-glucoside, isorhamnetin-3-O-rutinoside and isorhamnetin-3-O-robinobioside. The results showed a relationship between the extracts/fractions activities and their flavonoid contents. Moreover, the chloroform extract which was enriched with the aglycone flavonoid isorhamnetin exhibited the highest activities. The activities of N. retusa flavonoids were compared to those of model flavonoids, quercetin, isoquercitrin and rutin. In all cases, the aglycone compounds were more active than their glycosylated derivatives. Isorhamnetin-based flavonoids presented higher antiproliferative activities than quercetin-based ones, while similar antioxidant properties were observed. The enzymatic acylation of isorhamnetin-3-O-glucoside with ethyl laurate and ethyl butyrate enhanced its capacity to inhibit xanthine oxidase and its antiproliferative activity but decreased its radical scavenging activity.</div>
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<fC01 i1="01" l="ENG"><s0>The antioxidant activity and antiproliferative property towards Caco2 cells of water and methanol extracts/fractions of Nitraria retusa were investigated. The total phenolic and flavonoid contents of the extracts/fractions were determined, and the four major flavonoids were identified as isorhamnetin, isorhamnetin-3-0-glucoside, isorhamnetin-3-O-rutinoside and isorhamnetin-3-O-robinobioside. The results showed a relationship between the extracts/fractions activities and their flavonoid contents. Moreover, the chloroform extract which was enriched with the aglycone flavonoid isorhamnetin exhibited the highest activities. The activities of N. retusa flavonoids were compared to those of model flavonoids, quercetin, isoquercitrin and rutin. In all cases, the aglycone compounds were more active than their glycosylated derivatives. Isorhamnetin-based flavonoids presented higher antiproliferative activities than quercetin-based ones, while similar antioxidant properties were observed. The enzymatic acylation of isorhamnetin-3-O-glucoside with ethyl laurate and ethyl butyrate enhanced its capacity to inhibit xanthine oxidase and its antiproliferative activity but decreased its radical scavenging activity.</s0>
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<server><NO>PASCAL 10-0460265 INIST</NO>
<ET>Biological activities of flavonoids from Nitraria retusa (Forssk.) Asch. and their acylated derivatives</ET>
<AU>HADJ SALEM (Jamila); CHEVALOT (Isabelle); HARSCOAT-SCHIAVO (Christelle); PARIS (Cédric); FICK (Michel); HUMEAU (Catherine)</AU>
<AF>LRGP, Nancy Université, CNRS, 2 avenue de la forêt de Haye/54500 Vandoeuvre-lès-Nancy/France (1 aut., 2 aut., 3 aut., 5 aut.); LIBIO. Nancy Université, 2 avenue de la forêt de Haye/54500 Vandoeuvre-lès-Nancy/France (4 aut., 6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Food chemistry; ISSN 0308-8146; Coden FOCHDJ; Royaume-Uni; Da. 2010; Vol. 124; No. 2; Pp. 486-494; Bibl. 3/4 p.</SO>
<LA>Anglais</LA>
<EA>The antioxidant activity and antiproliferative property towards Caco2 cells of water and methanol extracts/fractions of Nitraria retusa were investigated. The total phenolic and flavonoid contents of the extracts/fractions were determined, and the four major flavonoids were identified as isorhamnetin, isorhamnetin-3-0-glucoside, isorhamnetin-3-O-rutinoside and isorhamnetin-3-O-robinobioside. The results showed a relationship between the extracts/fractions activities and their flavonoid contents. Moreover, the chloroform extract which was enriched with the aglycone flavonoid isorhamnetin exhibited the highest activities. The activities of N. retusa flavonoids were compared to those of model flavonoids, quercetin, isoquercitrin and rutin. In all cases, the aglycone compounds were more active than their glycosylated derivatives. Isorhamnetin-based flavonoids presented higher antiproliferative activities than quercetin-based ones, while similar antioxidant properties were observed. The enzymatic acylation of isorhamnetin-3-O-glucoside with ethyl laurate and ethyl butyrate enhanced its capacity to inhibit xanthine oxidase and its antiproliferative activity but decreased its radical scavenging activity.</EA>
<CC>002A35</CC>
<FD>Activité biologique; Flavonoïde; Réaction enzymatique; Acylation; Ester; Antioxydant; Anticancéreux</FD>
<FG>Polyphénol</FG>
<ED>Biological activity; Flavonoid; Enzymatic reaction; Acylation; Ester; Antioxidant; Antineoplastic agent</ED>
<EG>Polyphenol</EG>
<SD>Actividad biológica; Flavonoide; Reacción enzimática; Acilación; Ester; Antioxidante; Anticanceroso</SD>
<LO>INIST-17810.354000192678640110</LO>
<ID>10-0460265</ID>
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Biological activities of flavonoids from Nitraria retusa (Forssk.) Asch. and their acylated derivatives

Biological activities of flavonoids from Nitraria retusa (Forssk.) Asch. and their acylated derivatives

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