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Enduring increased risk of developing depression and mania in patients with dementia

Identifieur interne : 000024 ( Ncbi/Checkpoint ); précédent : 000023; suivant : 000025

Enduring increased risk of developing depression and mania in patients with dementia

Auteurs : F. Nilsson ; L. Kessing ; T. Sorensen ; P. Andersen ; T. Bolwig

Source :

RBID : PMC:1757324

Abstract

Objective: To investigate the time relation between dementia and major affective disorders (major depression and mania).

Methods: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models.

Results: Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life.

Conclusions: Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.


Url:
DOI: 10.1136/jnnp.73.1.40
PubMed: 12082043
PubMed Central: 1757324


Affiliations:


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PMC:1757324

Le document en format XML

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<name sortKey="Nilsson, F" sort="Nilsson, F" uniqKey="Nilsson F" first="F" last="Nilsson">F. Nilsson</name>
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<author>
<name sortKey="Kessing, L" sort="Kessing, L" uniqKey="Kessing L" first="L" last="Kessing">L. Kessing</name>
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<name sortKey="Sorensen, T" sort="Sorensen, T" uniqKey="Sorensen T" first="T" last="Sorensen">T. Sorensen</name>
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<name sortKey="Andersen, P" sort="Andersen, P" uniqKey="Andersen P" first="P" last="Andersen">P. Andersen</name>
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<name sortKey="Bolwig, T" sort="Bolwig, T" uniqKey="Bolwig T" first="T" last="Bolwig">T. Bolwig</name>
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<name sortKey="Kessing, L" sort="Kessing, L" uniqKey="Kessing L" first="L" last="Kessing">L. Kessing</name>
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<name sortKey="Andersen, P" sort="Andersen, P" uniqKey="Andersen P" first="P" last="Andersen">P. Andersen</name>
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<name sortKey="Bolwig, T" sort="Bolwig, T" uniqKey="Bolwig T" first="T" last="Bolwig">T. Bolwig</name>
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<series>
<title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title>
<idno type="ISSN">0022-3050</idno>
<idno type="eISSN">1468-330X</idno>
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<bold>Objective:</bold>
To investigate the time relation between dementia and major affective disorders (major depression and mania). </p>
<p>
<bold>Methods:</bold>
Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models. </p>
<p>
<bold>Results:</bold>
Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life. </p>
<p>
<bold>Conclusions:</bold>
Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs. </p>
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<name sortKey="Kessing, L" sort="Kessing, L" uniqKey="Kessing L" first="L" last="Kessing">L. Kessing</name>
<name sortKey="Nilsson, F" sort="Nilsson, F" uniqKey="Nilsson F" first="F" last="Nilsson">F. Nilsson</name>
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{{Explor lien
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   |area=    LrgpV1
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   |type=    RBID
   |clé=     PMC:1757324
   |texte=   Enduring increased risk of developing depression and mania in patients with dementia
}}

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