Surfactive water-soluble copolymers for the preparation of controlled surface nanoparticles by double emulsion/solvent evaporation.
Identifieur interne : 001466 ( Main/Merge ); précédent : 001465; suivant : 001467Surfactive water-soluble copolymers for the preparation of controlled surface nanoparticles by double emulsion/solvent evaporation.
Auteurs : David Chognot [France] ; Michèle Léonard ; Jean-Luc Six ; Édith Dellacherie [France]Source :
- Colloids and surfaces. B, Biointerfaces [ 0927-7765 ] ; 2006.
Descripteurs français
- KwdFr :
- Acide lactique (), Acide lactique (pharmacocinétique), Acide lactique (synthèse chimique), Colloïdes, Eau (), Matériaux biocompatibles (), Matériaux biocompatibles (pharmacocinétique), Matériaux biocompatibles (synthèse chimique), Nanostructures, Polymères (), Polymères (pharmacocinétique), Polymères (synthèse chimique), Propriétés de surface, Solubilité, Tensioactifs (), Tensioactifs (pharmacocinétique), Tensioactifs (synthèse chimique), Tension superficielle, Volatilisation, Émulsions.
- MESH :
- pharmacocinétique : Acide lactique, Matériaux biocompatibles, Polymères, Tensioactifs.
- synthèse chimique : Acide lactique, Matériaux biocompatibles, Polymères, Tensioactifs.
- Acide lactique, Colloïdes, Eau, Matériaux biocompatibles, Nanostructures, Polymères, Propriétés de surface, Solubilité, Tensioactifs, Tension superficielle, Volatilisation, Émulsions.
English descriptors
- KwdEn :
- Biocompatible Materials (chemical synthesis), Biocompatible Materials (chemistry), Biocompatible Materials (pharmacokinetics), Colloids, Emulsions, Lactic Acid (chemical synthesis), Lactic Acid (chemistry), Lactic Acid (pharmacokinetics), Nanostructures, Polymers (chemical synthesis), Polymers (chemistry), Polymers (pharmacokinetics), Solubility, Surface Properties, Surface Tension, Surface-Active Agents (chemical synthesis), Surface-Active Agents (chemistry), Surface-Active Agents (pharmacokinetics), Volatilization, Water (chemistry).
- MESH :
- chemical , chemical synthesis : Biocompatible Materials, Lactic Acid, Polymers, Surface-Active Agents.
- chemical , chemistry : Biocompatible Materials, Lactic Acid, Polymers, Surface-Active Agents, Water.
- chemical , pharmacokinetics : Biocompatible Materials, Lactic Acid, Polymers, Surface-Active Agents.
- chemical : Colloids, Emulsions.
- Nanostructures, Solubility, Surface Properties, Surface Tension, Volatilization.
Abstract
We have already shown that polylactide (PLA) nanoparticles covered with a hydrophilic polymeric layer can be prepared by simple emulsion/solvent evaporation by using amphiphilic copolymers as surfactants during the procedure. The external layer is then constituted by the hydrophilic part of the macromolecular surfactant. This kind of nanospheres is useful for the encapsulation of lipohilic molecules. The use of amphiphilic copolymers as surfactants in the preparation of PLA nanospheres with controlled surface properties, was then applied to the double emulsion/solvent evaporation procedure. The aim was to allow the encapsulation of water-soluble bioactive molecules in PLA particles with controlled surface properties. In this paper, we describe the results obtained with three different water-soluble monomethoxypolyethylene oxide (MPEO)-b-PLA diblock copolymers used as surfactants in the preparation of nanoparticles by double emulsion/solvent evaporation. After organic solvent evaporation, the obtained nanospheres were proved to be really covered by a MPEO layer whose characteristics were determined. It was firstly shown that the MPEO-covered particles did not flocculate at 25 degrees C, even in 4 M NaCl while suspensions of bare nanospheres were destabilized for a NaCl concentration as low as 0.04 M. On the other hand, the suspensions of MPEO-covered nanoparticles in 0.3 M Na2SO4 were found to be very sensitive to temperature as they flocculated at a temperature lying between 45 and 55 degrees C depending on the MPEO-b-PLA composition. This property was attributed to the fact that MPEO is a polymer with a low critical solution temperature. The concentration of MPEO at the nanoparticle surface was then calculated for the three kinds of particles, from the initial flocculation temperature, and was found to be comparable to the value determined directly.
DOI: 10.1016/j.colsurfb.2006.04.003
PubMed: 16806853
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pubmed:16806853Le document en format XML
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B, Biointerfaces</title><idno type="ISSN">0927-7765</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biocompatible Materials (chemical synthesis)</term><term>Biocompatible Materials (chemistry)</term><term>Biocompatible Materials (pharmacokinetics)</term><term>Colloids</term><term>Emulsions</term><term>Lactic Acid (chemical synthesis)</term><term>Lactic Acid (chemistry)</term><term>Lactic Acid (pharmacokinetics)</term><term>Nanostructures</term><term>Polymers (chemical synthesis)</term><term>Polymers (chemistry)</term><term>Polymers (pharmacokinetics)</term><term>Solubility</term><term>Surface Properties</term><term>Surface Tension</term><term>Surface-Active Agents (chemical synthesis)</term><term>Surface-Active Agents (chemistry)</term><term>Surface-Active Agents (pharmacokinetics)</term><term>Volatilization</term><term>Water (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide lactique ()</term><term>Acide lactique (pharmacocinétique)</term><term>Acide lactique (synthèse chimique)</term><term>Colloïdes</term><term>Eau ()</term><term>Matériaux biocompatibles ()</term><term>Matériaux biocompatibles (pharmacocinétique)</term><term>Matériaux biocompatibles (synthèse chimique)</term><term>Nanostructures</term><term>Polymères ()</term><term>Polymères (pharmacocinétique)</term><term>Polymères (synthèse chimique)</term><term>Propriétés de surface</term><term>Solubilité</term><term>Tensioactifs ()</term><term>Tensioactifs (pharmacocinétique)</term><term>Tensioactifs (synthèse chimique)</term><term>Tension superficielle</term><term>Volatilisation</term><term>Émulsions</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Biocompatible Materials</term><term>Lactic Acid</term><term>Polymers</term><term>Surface-Active Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Biocompatible Materials</term><term>Lactic Acid</term><term>Polymers</term><term>Surface-Active Agents</term><term>Water</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Biocompatible Materials</term><term>Lactic Acid</term><term>Polymers</term><term>Surface-Active Agents</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Colloids</term><term>Emulsions</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Acide lactique</term><term>Matériaux biocompatibles</term><term>Polymères</term><term>Tensioactifs</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Acide lactique</term><term>Matériaux biocompatibles</term><term>Polymères</term><term>Tensioactifs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Nanostructures</term><term>Solubility</term><term>Surface Properties</term><term>Surface Tension</term><term>Volatilization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acide lactique</term><term>Colloïdes</term><term>Eau</term><term>Matériaux biocompatibles</term><term>Nanostructures</term><term>Polymères</term><term>Propriétés de surface</term><term>Solubilité</term><term>Tensioactifs</term><term>Tension superficielle</term><term>Volatilisation</term><term>Émulsions</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have already shown that polylactide (PLA) nanoparticles covered with a hydrophilic polymeric layer can be prepared by simple emulsion/solvent evaporation by using amphiphilic copolymers as surfactants during the procedure. The external layer is then constituted by the hydrophilic part of the macromolecular surfactant. This kind of nanospheres is useful for the encapsulation of lipohilic molecules. The use of amphiphilic copolymers as surfactants in the preparation of PLA nanospheres with controlled surface properties, was then applied to the double emulsion/solvent evaporation procedure. The aim was to allow the encapsulation of water-soluble bioactive molecules in PLA particles with controlled surface properties. In this paper, we describe the results obtained with three different water-soluble monomethoxypolyethylene oxide (MPEO)-b-PLA diblock copolymers used as surfactants in the preparation of nanoparticles by double emulsion/solvent evaporation. After organic solvent evaporation, the obtained nanospheres were proved to be really covered by a MPEO layer whose characteristics were determined. It was firstly shown that the MPEO-covered particles did not flocculate at 25 degrees C, even in 4 M NaCl while suspensions of bare nanospheres were destabilized for a NaCl concentration as low as 0.04 M. On the other hand, the suspensions of MPEO-covered nanoparticles in 0.3 M Na2SO4 were found to be very sensitive to temperature as they flocculated at a temperature lying between 45 and 55 degrees C depending on the MPEO-b-PLA composition. This property was attributed to the fact that MPEO is a polymer with a low critical solution temperature. The concentration of MPEO at the nanoparticle surface was then calculated for the three kinds of particles, from the initial flocculation temperature, and was found to be comparable to the value determined directly.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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