Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI.
Identifieur interne : 000245 ( Main/Exploration ); précédent : 000244; suivant : 000246Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI.
Auteurs : Denise Bechet [France] ; Florent Auger [France] ; Pierre Couleaud [France] ; Eric Marty [France] ; Laura Ravasi [France] ; Nicolas Durieux [France] ; Corinne Bonnet ; François Plénat [France] ; Céline Frochot [France] ; Serge Mordon ; Olivier Tillement [France] ; Régis Vanderesse [France] ; François Lux [France] ; Pascal Perriat [France] ; François Guillemin [France] ; Muriel Barberi-Heyob [France]Source :
- Nanomedicine : nanotechnology, biology, and medicine [ 1549-9642 ] ; 2015.
Descripteurs français
- KwdFr :
- Angiographie par résonance magnétique, Animaux, Femelle, Gliome (), Gliome (traitement médicamenteux), Humains, Lignée cellulaire tumorale, Nanoparticules (), Nanoparticules (usage thérapeutique), Neuropiline 1 (), Neuropiline 1 (usage thérapeutique), Photosensibilisants (), Photosensibilisants (pharmacologie), Photothérapie dynamique (), Rat nude, Rats, Tumeurs du cerveau (), Tumeurs du cerveau (traitement médicamenteux).
- MESH :
- pharmacologie : Photosensibilisants.
- traitement médicamenteux : Gliome, Tumeurs du cerveau.
- usage thérapeutique : Nanoparticules, Neuropiline 1.
- Angiographie par résonance magnétique, Animaux, Femelle, Gliome, Humains, Lignée cellulaire tumorale, Nanoparticules, Neuropiline 1, Photosensibilisants, Photothérapie dynamique, Rat nude, Rats, Tumeurs du cerveau.
English descriptors
- KwdEn :
- Animals, Brain Neoplasms (drug therapy), Brain Neoplasms (radiography), Cell Line, Tumor, Female, Glioma (drug therapy), Glioma (radiography), Humans, Magnetic Resonance Angiography, Nanoparticles (chemistry), Nanoparticles (therapeutic use), Neuropilin-1 (chemistry), Neuropilin-1 (therapeutic use), Photochemotherapy (methods), Photosensitizing Agents (chemistry), Photosensitizing Agents (pharmacology), Rats, Rats, Nude.
- MESH :
- chemical , chemistry : Neuropilin-1, Photosensitizing Agents.
- chemistry : Nanoparticles.
- drug therapy : Brain Neoplasms, Glioma.
- methods : Photochemotherapy.
- chemical , pharmacology : Photosensitizing Agents.
- radiography : Brain Neoplasms, Glioma.
- therapeutic use : Nanoparticles, Neuropilin-1.
- Animals, Cell Line, Tumor, Female, Humans, Magnetic Resonance Angiography, Rats, Rats, Nude.
- mix :
Abstract
Photodynamic therapy (PDT) for brain tumors appears to be complementary to conventional treatments. A number of studies show the major role of the vascular effect in the tumor eradication by PDT. For interstitial PDT (iPDT) of brain tumors guided by real-time imaging, multifunctional nanoparticles consisting of a surface-localized tumor vasculature targeting neuropilin-1 (NRP-1) peptide and encapsulated photosensitizer and magnetic resonance imaging (MRI) contrast agents, have been designed. Nanoplatforms confer photosensitivity to cells and demonstrate a molecular affinity to NRP-1. Intravenous injection into rats bearing intracranial glioma exhibited a dynamic contrast-enhanced MRI for angiogenic endothelial cells lining the neovessels mainly located in the peripheral tumor. By using MRI completed by NRP-1 protein expression of the tumor and brain adjacent to tumor tissues, we checked the selectivity of the nanoparticles. This study represents the first in vivo proof of concept of closed-head iPDT guided by real-time MRI using targeted ultrasmall nanoplatforms. From the clinical editor: The authors constructed tumor vascular peptide targeting multifunctional silica-based nanoparticles, with encapsulated gadolinium oxide as MRI contrast agent and chlorin as a photosensitizer, as a proof of concept novel treatment for glioblastoma in an animal model.
Url:
DOI: 10.1016/j.nano.2014.12.007
PubMed: 25645959
Affiliations:
- France
- Auvergne-Rhône-Alpes, Grand Est, Hauts-de-France, Lorraine (région), Nord-Pas-de-Calais, Rhône-Alpes
- Lille, Lyon, Metz, Nancy, Vandœuvre-lès-Nancy
- Université de Lorraine
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name>
<affiliation wicri:level="4"><nlm:affiliation>LRGP UMR 7274, CNRS, Nancy, France; LRGP UMR 7274, Université de Lorraine, Nancy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>LRGP UMR 7274, CNRS, Nancy, France; LRGP UMR 7274, Université de Lorraine, Nancy</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Lorraine (région)</region>
<settlement type="city">Nancy</settlement>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Mordon, Serge" sort="Mordon, Serge" uniqKey="Mordon S" first="Serge" last="Mordon">Serge Mordon</name>
<affiliation><nlm:affiliation>INSERM U1189, Lille University Hospital, Lille.</nlm:affiliation>
<wicri:noCountry code="subField">Lille</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tillement, Olivier" sort="Tillement, Olivier" uniqKey="Tillement O" first="Olivier" last="Tillement">Olivier Tillement</name>
<affiliation wicri:level="3"><nlm:affiliation>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vanderesse, Regis" sort="Vanderesse, Regis" uniqKey="Vanderesse R" first="Régis" last="Vanderesse">Régis Vanderesse</name>
<affiliation wicri:level="4"><nlm:affiliation>LCPM FRE 3564, CNRS, Nancy, France; LCPM FRE 3564, Université de Lorraine, Nancy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>LCPM FRE 3564, CNRS, Nancy, France; LCPM FRE 3564, Université de Lorraine, Nancy</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Lorraine (région)</region>
<settlement type="city">Nancy</settlement>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Lux, Francois" sort="Lux, Francois" uniqKey="Lux F" first="François" last="Lux">François Lux</name>
<affiliation wicri:level="3"><nlm:affiliation>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perriat, Pascal" sort="Perriat, Pascal" uniqKey="Perriat P" first="Pascal" last="Perriat">Pascal Perriat</name>
<affiliation wicri:level="3"><nlm:affiliation>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guillemin, Francois" sort="Guillemin, Francois" uniqKey="Guillemin F" first="François" last="Guillemin">François Guillemin</name>
<affiliation wicri:level="4"><nlm:affiliation>CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
<settlement type="city">Vandœuvre-lès-Nancy</settlement>
<settlement type="city" wicri:auto="agglo">Nancy</settlement>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Barberi Heyob, Muriel" sort="Barberi Heyob, Muriel" uniqKey="Barberi Heyob M" first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name>
<affiliation wicri:level="4"><nlm:affiliation>CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France. Electronic address: muriel.barberi@univ-lorraine.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
<settlement type="city">Vandœuvre-lès-Nancy</settlement>
<settlement type="city" wicri:auto="agglo">Nancy</settlement>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nanomedicine : nanotechnology, biology, and medicine</title>
<idno type="eISSN">1549-9642</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Brain Neoplasms (drug therapy)</term>
<term>Brain Neoplasms (radiography)</term>
<term>Cell Line, Tumor</term>
<term>Female</term>
<term>Glioma (drug therapy)</term>
<term>Glioma (radiography)</term>
<term>Humans</term>
<term>Magnetic Resonance Angiography</term>
<term>Nanoparticles (chemistry)</term>
<term>Nanoparticles (therapeutic use)</term>
<term>Neuropilin-1 (chemistry)</term>
<term>Neuropilin-1 (therapeutic use)</term>
<term>Photochemotherapy (methods)</term>
<term>Photosensitizing Agents (chemistry)</term>
<term>Photosensitizing Agents (pharmacology)</term>
<term>Rats</term>
<term>Rats, Nude</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Angiographie par résonance magnétique</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Gliome ()</term>
<term>Gliome (traitement médicamenteux)</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Nanoparticules ()</term>
<term>Nanoparticules (usage thérapeutique)</term>
<term>Neuropiline 1 ()</term>
<term>Neuropiline 1 (usage thérapeutique)</term>
<term>Photosensibilisants ()</term>
<term>Photosensibilisants (pharmacologie)</term>
<term>Photothérapie dynamique ()</term>
<term>Rat nude</term>
<term>Rats</term>
<term>Tumeurs du cerveau ()</term>
<term>Tumeurs du cerveau (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Neuropilin-1</term>
<term>Photosensitizing Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Brain Neoplasms</term>
<term>Glioma</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Photochemotherapy</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Photosensibilisants</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Photosensitizing Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="radiography" xml:lang="en"><term>Brain Neoplasms</term>
<term>Glioma</term>
</keywords>
<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Nanoparticles</term>
<term>Neuropilin-1</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Gliome</term>
<term>Tumeurs du cerveau</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Nanoparticules</term>
<term>Neuropiline 1</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line, Tumor</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Angiography</term>
<term>Rats</term>
<term>Rats, Nude</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Angiographie par résonance magnétique</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Gliome</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Nanoparticules</term>
<term>Neuropiline 1</term>
<term>Photosensibilisants</term>
<term>Photothérapie dynamique</term>
<term>Rat nude</term>
<term>Rats</term>
<term>Tumeurs du cerveau</term>
</keywords>
<keywords scheme="mix" xml:lang="en"><term>brain tumor</term>
<term>iPDT</term>
<term>multifunctional nanoplateforms</term>
<term>real-time MRI</term>
<term>targeting</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Photodynamic therapy (PDT) for brain tumors appears to be complementary to conventional treatments. A number of studies show the major role of the vascular effect in the tumor eradication by PDT. For interstitial PDT (iPDT) of brain tumors guided by real-time imaging, multifunctional nanoparticles consisting of a surface-localized tumor vasculature targeting neuropilin-1 (NRP-1) peptide and encapsulated photosensitizer and magnetic resonance imaging (MRI) contrast agents, have been designed. Nanoplatforms confer photosensitivity to cells and demonstrate a molecular affinity to NRP-1. Intravenous injection into rats bearing intracranial glioma exhibited a dynamic contrast-enhanced MRI for angiogenic endothelial cells lining the neovessels mainly located in the peripheral tumor. By using MRI completed by NRP-1 protein expression of the tumor and brain adjacent to tumor tissues, we checked the selectivity of the nanoparticles. This study represents the first in vivo proof of concept of closed-head iPDT guided by real-time MRI using targeted ultrasmall nanoplatforms. From the clinical editor: The authors constructed tumor vascular peptide targeting multifunctional silica-based nanoparticles, with encapsulated gadolinium oxide as MRI contrast agent and chlorin as a photosensitizer, as a proof of concept novel treatment for glioblastoma in an animal model.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Grand Est</li>
<li>Hauts-de-France</li>
<li>Lorraine (région)</li>
<li>Nord-Pas-de-Calais</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Lille</li>
<li>Lyon</li>
<li>Metz</li>
<li>Nancy</li>
<li>Vandœuvre-lès-Nancy</li>
</settlement>
<orgName><li>Université de Lorraine</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Bonnet, Corinne" sort="Bonnet, Corinne" uniqKey="Bonnet C" first="Corinne" last="Bonnet">Corinne Bonnet</name>
<name sortKey="Mordon, Serge" sort="Mordon, Serge" uniqKey="Mordon S" first="Serge" last="Mordon">Serge Mordon</name>
</noCountry>
<country name="France"><region name="Grand Est"><name sortKey="Bechet, Denise" sort="Bechet, Denise" uniqKey="Bechet D" first="Denise" last="Bechet">Denise Bechet</name>
</region>
<name sortKey="Auger, Florent" sort="Auger, Florent" uniqKey="Auger F" first="Florent" last="Auger">Florent Auger</name>
<name sortKey="Barberi Heyob, Muriel" sort="Barberi Heyob, Muriel" uniqKey="Barberi Heyob M" first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name>
<name sortKey="Couleaud, Pierre" sort="Couleaud, Pierre" uniqKey="Couleaud P" first="Pierre" last="Couleaud">Pierre Couleaud</name>
<name sortKey="Durieux, Nicolas" sort="Durieux, Nicolas" uniqKey="Durieux N" first="Nicolas" last="Durieux">Nicolas Durieux</name>
<name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name>
<name sortKey="Guillemin, Francois" sort="Guillemin, Francois" uniqKey="Guillemin F" first="François" last="Guillemin">François Guillemin</name>
<name sortKey="Lux, Francois" sort="Lux, Francois" uniqKey="Lux F" first="François" last="Lux">François Lux</name>
<name sortKey="Marty, Eric" sort="Marty, Eric" uniqKey="Marty E" first="Eric" last="Marty">Eric Marty</name>
<name sortKey="Perriat, Pascal" sort="Perriat, Pascal" uniqKey="Perriat P" first="Pascal" last="Perriat">Pascal Perriat</name>
<name sortKey="Plenat, Francois" sort="Plenat, Francois" uniqKey="Plenat F" first="François" last="Plénat">François Plénat</name>
<name sortKey="Ravasi, Laura" sort="Ravasi, Laura" uniqKey="Ravasi L" first="Laura" last="Ravasi">Laura Ravasi</name>
<name sortKey="Tillement, Olivier" sort="Tillement, Olivier" uniqKey="Tillement O" first="Olivier" last="Tillement">Olivier Tillement</name>
<name sortKey="Vanderesse, Regis" sort="Vanderesse, Regis" uniqKey="Vanderesse R" first="Régis" last="Vanderesse">Régis Vanderesse</name>
</country>
</tree>
</affiliations>
</record>
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