LrgpV1, Main, Exploration, bibRecord, 001B20

The position of the LysNεH2‐grafted antigens along the sequential oligopeptide carrier, Ac‐(Aib‐Lys‐Aib‐Gly)n (SOCn‐II), influences the antibody recognition: Application to the Sm main autoimmune epitope

Identifieur interne : 001B20 ( Main/Exploration ); précédent : 001B19; suivant : 001B21

The position of the LysNεH2‐grafted antigens along the sequential oligopeptide carrier, Ac‐(Aib‐Lys‐Aib‐Gly)n (SOCn‐II), influences the antibody recognition: Application to the Sm main autoimmune epitope

Auteurs : Charalampos Alexopoulos [Grèce] ; Vassilios Tsikaris [Grèce] ; Catherina Rizou [Grèce] ; Maria Sakarellos-Daitsiotis [Grèce] ; Constantinos Sakarellos [Grèce] ; Manh Thong Cung [France] ; Michel Marraud (chimiste) [France] ; Panayiotis G. Vlachoyiannopoulos [Grèce] ; Haralampos M. Moutsopoulos [Grèce]

Source :

Biopolymers [ 0006-3525 ] ; 2000-07.

RBID : ISTEX:000B101A9D7ABD2439E98928916DD704029DF0AC

English descriptors

Abstract

A sequential oligopeptide carrier of antigenic peptides is presented, incorporating two Aib residues in each repetitive moiety: Ac–(Aib–Lys–Aib–Gly)n (SOCn ‐II; n = 2–4). The conformational study, by 1H‐nmr, CD, and Fourier transform ir spectroscopy, indicated that the SOCn ‐II carrier displays a pronounced 310‐helix, compared to the Ac–(Lys–Aib–Gly)n (SOCn ‐I) carrier of the same approximately backbone length, previously reported. One of the dominant autoimmune epitopes of the Sm and U1RNP cellular components, the PPGMRPP sequence, was coupled to the Lys‐NεH2 groups of the SOCn ‐II carrier and used as antigenic substrate for detecting anti‐Sm/U1RNP autoantibodies in ELISA assays. Anti‐Sm antibodies are highly specific for systemic lupus erythematosus, while anti‐U1RNP are specific for mixed connective tissue disease. The anti‐(PPGMRPP)5‐SOCn ‐II ELISA was compared with the anti‐(PPGMRPP)n –SOCn ‐I ELISA, provided that both antigenic substrates possess the same amount of the epitope replicates. The significance of the lysine positions along the oligopeptide backbone of the carrier for a favorable antibody recognition of the anchored antigens is also examined. © 2000 John Wiley & Sons, Inc. Biopoly 54: 1–10, 2000

Url:

https://api.istex.fr/document/000B101A9D7ABD2439E98928916DD704029DF0AC/fulltext/pdf

DOI: 10.1002/(SICI)1097-0282(200007)54:1<1::AID-BIP10>3.0.CO;2-7

Affiliations:

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Le document en format XML

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<author><name sortKey="Alexopoulos, Charalampos" sort="Alexopoulos, Charalampos" uniqKey="Alexopoulos C" first="Charalampos" last="Alexopoulos">Charalampos Alexopoulos</name>
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<series><title level="j" type="main">Biopolymers</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Absorbance units</term>
<term>Alexopoulos</term>
<term>Amide</term>
<term>Analytical hplc</term>
<term>Antibody recognition</term>
<term>Antigenic</term>
<term>Antigenic determinants</term>
<term>Antigenic peptides</term>
<term>Aqueous solutions</term>
<term>Binding capacity</term>
<term>Biological experiments</term>
<term>Carrier displays</term>
<term>Chemical shifts</term>
<term>Conformational study</term>
<term>Connective tissue disease</term>
<term>Consecutive lysines</term>
<term>Elisa</term>
<term>Elisa plate</term>
<term>Elisa plates</term>
<term>Epitope</term>
<term>Epitope concentration</term>
<term>Epitope ppgmrpp</term>
<term>Epitope replicates</term>
<term>Favorable antibody recognition</term>
<term>Gly3 met4 arg5 pro6 pro7 pro1 pro2</term>
<term>Greek secretariat</term>
<term>Helical</term>
<term>Helical content</term>
<term>Helical structure</term>
<term>Helicoid structure</term>
<term>High content</term>
<term>Hplc</term>
<term>Immunol methods</term>
<term>Jobin yvon</term>
<term>John wiley sons</term>
<term>Lysine</term>
<term>Lysine positions</term>
<term>Magn reson</term>
<term>Main target</term>
<term>Molar ratio</term>
<term>Oligopeptide</term>
<term>Oligopeptide backbone</term>
<term>Peptide</term>
<term>Peptide protein</term>
<term>Peptide synthesis</term>
<term>Phosphate buffer</term>
<term>Potent antigens</term>
<term>Ppgmrpp</term>
<term>Ppgmrpp epitopes</term>
<term>Ppgmrpp sequence</term>
<term>Previous studies</term>
<term>Proc natl acad</term>
<term>Repetitive moiety</term>
<term>Room temperature</term>
<term>Sakarellos</term>
<term>Same amount</term>
<term>Same backbone length</term>
<term>Scan accumulation</term>
<term>Schematic representation</term>
<term>Sequence ppgmrpp</term>
<term>Sequential</term>
<term>Sequential oligopeptide carrier</term>
<term>Sequential oligopeptide carriers</term>
<term>Socn</term>
<term>Solid state</term>
<term>Steric hindrances</term>
<term>Structural motif</term>
<term>Systemic lupus erythematosus</term>
<term>Temperature values</term>
<term>Tsikaris</term>
<term>U1rnp autoantibodies</term>
<term>U1rnp autoantigens</term>
<term>Various concentrations</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Absorbance units</term>
<term>Alexopoulos</term>
<term>Amide</term>
<term>Analytical hplc</term>
<term>Antibody recognition</term>
<term>Antigenic</term>
<term>Antigenic determinants</term>
<term>Antigenic peptides</term>
<term>Aqueous solutions</term>
<term>Binding capacity</term>
<term>Biological experiments</term>
<term>Carrier displays</term>
<term>Chemical shifts</term>
<term>Conformational study</term>
<term>Connective tissue disease</term>
<term>Consecutive lysines</term>
<term>Elisa</term>
<term>Elisa plate</term>
<term>Elisa plates</term>
<term>Epitope</term>
<term>Epitope concentration</term>
<term>Epitope ppgmrpp</term>
<term>Epitope replicates</term>
<term>Favorable antibody recognition</term>
<term>Gly3 met4 arg5 pro6 pro7 pro1 pro2</term>
<term>Greek secretariat</term>
<term>Helical</term>
<term>Helical content</term>
<term>Helical structure</term>
<term>Helicoid structure</term>
<term>High content</term>
<term>Hplc</term>
<term>Immunol methods</term>
<term>Jobin yvon</term>
<term>John wiley sons</term>
<term>Lysine</term>
<term>Lysine positions</term>
<term>Magn reson</term>
<term>Main target</term>
<term>Molar ratio</term>
<term>Oligopeptide</term>
<term>Oligopeptide backbone</term>
<term>Peptide</term>
<term>Peptide protein</term>
<term>Peptide synthesis</term>
<term>Phosphate buffer</term>
<term>Potent antigens</term>
<term>Ppgmrpp</term>
<term>Ppgmrpp epitopes</term>
<term>Ppgmrpp sequence</term>
<term>Previous studies</term>
<term>Proc natl acad</term>
<term>Repetitive moiety</term>
<term>Room temperature</term>
<term>Sakarellos</term>
<term>Same amount</term>
<term>Same backbone length</term>
<term>Scan accumulation</term>
<term>Schematic representation</term>
<term>Sequence ppgmrpp</term>
<term>Sequential</term>
<term>Sequential oligopeptide carrier</term>
<term>Sequential oligopeptide carriers</term>
<term>Socn</term>
<term>Solid state</term>
<term>Steric hindrances</term>
<term>Structural motif</term>
<term>Systemic lupus erythematosus</term>
<term>Temperature values</term>
<term>Tsikaris</term>
<term>U1rnp autoantibodies</term>
<term>U1rnp autoantigens</term>
<term>Various concentrations</term>
</keywords>
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<front><div type="abstract" xml:lang="en">A sequential oligopeptide carrier of antigenic peptides is presented, incorporating two Aib residues in each repetitive moiety: Ac–(Aib–Lys–Aib–Gly)n (SOCn ‐II; n = 2–4). The conformational study, by 1H‐nmr, CD, and Fourier transform ir spectroscopy, indicated that the SOCn ‐II carrier displays a pronounced 310‐helix, compared to the Ac–(Lys–Aib–Gly)n (SOCn ‐I) carrier of the same approximately backbone length, previously reported. One of the dominant autoimmune epitopes of the Sm and U1RNP cellular components, the PPGMRPP sequence, was coupled to the Lys‐NεH2 groups of the SOCn ‐II carrier and used as antigenic substrate for detecting anti‐Sm/U1RNP autoantibodies in ELISA assays. Anti‐Sm antibodies are highly specific for systemic lupus erythematosus, while anti‐U1RNP are specific for mixed connective tissue disease. The anti‐(PPGMRPP)5‐SOCn ‐II ELISA was compared with the anti‐(PPGMRPP)n –SOCn ‐I ELISA, provided that both antigenic substrates possess the same amount of the epitope replicates. The significance of the lysine positions along the oligopeptide backbone of the carrier for a favorable antibody recognition of the anchored antigens is also examined. © 2000 John Wiley & Sons, Inc. Biopoly 54: 1–10, 2000</div>
</front>
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<tree><country name="Grèce"><noRegion><name sortKey="Alexopoulos, Charalampos" sort="Alexopoulos, Charalampos" uniqKey="Alexopoulos C" first="Charalampos" last="Alexopoulos">Charalampos Alexopoulos</name>
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<name sortKey="Moutsopoulos, Haralampos M" sort="Moutsopoulos, Haralampos M" uniqKey="Moutsopoulos H" first="Haralampos M." last="Moutsopoulos">Haralampos M. Moutsopoulos</name>
<name sortKey="Rizou, Catherina" sort="Rizou, Catherina" uniqKey="Rizou C" first="Catherina" last="Rizou">Catherina Rizou</name>
<name sortKey="Sakarellos Aitsiotis, Maria" sort="Sakarellos Aitsiotis, Maria" uniqKey="Sakarellos Aitsiotis M" first="Maria" last="Sakarellos-Daitsiotis">Maria Sakarellos-Daitsiotis</name>
<name sortKey="Sakarellos, Constantinos" sort="Sakarellos, Constantinos" uniqKey="Sakarellos C" first="Constantinos" last="Sakarellos">Constantinos Sakarellos</name>
<name sortKey="Tsikaris, Vassilios" sort="Tsikaris, Vassilios" uniqKey="Tsikaris V" first="Vassilios" last="Tsikaris">Vassilios Tsikaris</name>
<name sortKey="Tsikaris, Vassilios" sort="Tsikaris, Vassilios" uniqKey="Tsikaris V" first="Vassilios" last="Tsikaris">Vassilios Tsikaris</name>
<name sortKey="Vlachoyiannopoulos, Panayiotis G" sort="Vlachoyiannopoulos, Panayiotis G" uniqKey="Vlachoyiannopoulos P" first="Panayiotis G." last="Vlachoyiannopoulos">Panayiotis G. Vlachoyiannopoulos</name>
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<country name="France"><region name="Grand Est"><name sortKey="Cung, Manh Thong" sort="Cung, Manh Thong" uniqKey="Cung M" first="Manh Thong" last="Cung">Manh Thong Cung</name>
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<name sortKey="Marraud, Michel" sort="Marraud, Michel" uniqKey="Marraud M" first="Michel" last="Marraud">Michel Marraud (chimiste)</name>
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The position of the LysNεH2‐grafted antigens along the sequential oligopeptide carrier, Ac‐(Aib‐Lys‐Aib‐Gly)n (SOCn‐II), influences the antibody recognition: Application to the Sm main autoimmune epitope

The position of the LysNεH2‐grafted antigens along the sequential oligopeptide carrier, Ac‐(Aib‐Lys‐Aib‐Gly)n (SOCn‐II), influences the antibody recognition: Application to the Sm main autoimmune epitope

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Abstract

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