Synthesis and photophysical properties of the photoactivatable cationic porphyrin 5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide for anti-malaria PDT.
Identifieur interne : 000232 ( Main/Exploration ); précédent : 000231; suivant : 000233Synthesis and photophysical properties of the photoactivatable cationic porphyrin 5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide for anti-malaria PDT.
Auteurs : Aurélie Stallivieri [France] ; Florent Le Guern ; Régis Vanderesse ; Esme Meledje ; Giulio Jori ; Céline Frochot ; Samir AcherarSource :
- Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology [ 1474-9092 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Antipaludiques (pharmacologie), Antipaludiques (synthèse chimique), Composés de pyridinium (pharmacologie), Composés de pyridinium (synthèse chimique), Culicidae (), Culicidae (effets des radiations), Larve (), Larve (effets des radiations), Lumière du soleil, Lutte contre les moustiques (), Paludisme (), Porphyrines (pharmacologie), Porphyrines (synthèse chimique), Structure moléculaire.
- MESH :
- effets des radiations : Culicidae, Larve.
- pharmacologie : Antipaludiques, Composés de pyridinium, Porphyrines.
- synthèse chimique : Antipaludiques, Composés de pyridinium, Porphyrines.
- Animaux, Culicidae, Larve, Lumière du soleil, Lutte contre les moustiques, Paludisme, Structure moléculaire.
English descriptors
- KwdEn :
- Animals, Antimalarials (chemical synthesis), Antimalarials (pharmacology), Culicidae (drug effects), Culicidae (radiation effects), Larva (drug effects), Larva (radiation effects), Malaria (prevention & control), Molecular Structure, Mosquito Control (methods), Porphyrins (chemical synthesis), Porphyrins (pharmacology), Pyridinium Compounds (chemical synthesis), Pyridinium Compounds (pharmacology), Sunlight.
- MESH :
- chemical , chemical synthesis : Antimalarials, Porphyrins, Pyridinium Compounds.
- chemical , pharmacology : Antimalarials, Porphyrins, Pyridinium Compounds.
- drug effects : Culicidae, Larva.
- methods : Mosquito Control.
- prevention & control : Malaria.
- radiation effects : Culicidae, Larva.
- Animals, Molecular Structure, Sunlight.
Abstract
This article describes a new synthetic method for obtaining three water soluble porphyrins. The more sophisticated porphyrin [5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide], also named C12 porphyrin, was obtained through a three step methodology. The improvements, compared to syntheses described in the literature, mostly concern the purification procedures. The photophysical properties of the three porphyrins are described and the C12 porphyrin presents a very good (1)O2 yield compared to its chemical intermediates. This porphyrin seems to be a very promising candidate for PDT applications.
Url:
DOI: 10.1039/c5pp00139k
PubMed: 26066986
Affiliations:
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Le document en format XML
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Université de Lorraine, UMR 7274, 1 rue Grandville BP 20451, Nancy Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine, UMR 7274, 1 rue Grandville BP 20451, Nancy Cedex</wicri:regionArea><wicri:noRegion>20451, Nancy Cedex</wicri:noRegion><orgName type="university">Université de Lorraine</orgName><placeName><settlement type="city">Nancy</settlement><settlement type="city">Metz</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region></placeName></affiliation></author><author><name sortKey="Le Guern, Florent" sort="Le Guern, Florent" uniqKey="Le Guern F" first="Florent" last="Le Guern">Florent Le Guern</name></author><author><name sortKey="Vanderesse, Regis" sort="Vanderesse, Regis" uniqKey="Vanderesse R" first="Régis" last="Vanderesse">Régis Vanderesse</name></author><author><name sortKey="Meledje, Esme" sort="Meledje, Esme" uniqKey="Meledje E" first="Esme" last="Meledje">Esme Meledje</name></author><author><name sortKey="Jori, Giulio" sort="Jori, Giulio" uniqKey="Jori G" first="Giulio" last="Jori">Giulio Jori</name></author><author><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name></author><author><name sortKey="Acherar, Samir" sort="Acherar, Samir" uniqKey="Acherar S" first="Samir" last="Acherar">Samir Acherar</name></author></analytic><series><title level="j">Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology</title><idno type="eISSN">1474-9092</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antimalarials (chemical synthesis)</term><term>Antimalarials (pharmacology)</term><term>Culicidae (drug effects)</term><term>Culicidae (radiation effects)</term><term>Larva (drug effects)</term><term>Larva (radiation effects)</term><term>Malaria (prevention & control)</term><term>Molecular Structure</term><term>Mosquito Control (methods)</term><term>Porphyrins (chemical synthesis)</term><term>Porphyrins (pharmacology)</term><term>Pyridinium Compounds (chemical synthesis)</term><term>Pyridinium Compounds (pharmacology)</term><term>Sunlight</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antipaludiques (pharmacologie)</term><term>Antipaludiques (synthèse chimique)</term><term>Composés de pyridinium (pharmacologie)</term><term>Composés de pyridinium (synthèse chimique)</term><term>Culicidae ()</term><term>Culicidae (effets des radiations)</term><term>Larve ()</term><term>Larve (effets des radiations)</term><term>Lumière du soleil</term><term>Lutte contre les moustiques ()</term><term>Paludisme ()</term><term>Porphyrines (pharmacologie)</term><term>Porphyrines (synthèse chimique)</term><term>Structure moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antimalarials</term><term>Porphyrins</term><term>Pyridinium Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term><term>Porphyrins</term><term>Pyridinium Compounds</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Culicidae</term><term>Larva</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Culicidae</term><term>Larve</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mosquito Control</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antipaludiques</term><term>Composés de pyridinium</term><term>Porphyrines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Malaria</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Culicidae</term><term>Larva</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antipaludiques</term><term>Composés de pyridinium</term><term>Porphyrines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Molecular Structure</term><term>Sunlight</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Culicidae</term><term>Larve</term><term>Lumière du soleil</term><term>Lutte contre les moustiques</term><term>Paludisme</term><term>Structure moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This article describes a new synthetic method for obtaining three water soluble porphyrins. The more sophisticated porphyrin [5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide], also named C12 porphyrin, was obtained through a three step methodology. The improvements, compared to syntheses described in the literature, mostly concern the purification procedures. The photophysical properties of the three porphyrins are described and the C12 porphyrin presents a very good (1)O2 yield compared to its chemical intermediates. This porphyrin seems to be a very promising candidate for PDT applications.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Grand Est</li><li>Lorraine (région)</li></region><settlement><li>Metz</li><li>Nancy</li></settlement><orgName><li>Université de Lorraine</li></orgName></list><tree><noCountry><name sortKey="Acherar, Samir" sort="Acherar, Samir" uniqKey="Acherar S" first="Samir" last="Acherar">Samir Acherar</name><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name><name sortKey="Jori, Giulio" sort="Jori, Giulio" uniqKey="Jori G" first="Giulio" last="Jori">Giulio Jori</name><name sortKey="Le Guern, Florent" sort="Le Guern, Florent" uniqKey="Le Guern F" first="Florent" last="Le Guern">Florent Le Guern</name><name sortKey="Meledje, Esme" sort="Meledje, Esme" uniqKey="Meledje E" first="Esme" last="Meledje">Esme Meledje</name><name sortKey="Vanderesse, Regis" sort="Vanderesse, Regis" uniqKey="Vanderesse R" first="Régis" last="Vanderesse">Régis Vanderesse</name></noCountry><country name="France"><region name="Grand Est"><name sortKey="Stallivieri, Aurelie" sort="Stallivieri, Aurelie" uniqKey="Stallivieri A" first="Aurélie" last="Stallivieri">Aurélie Stallivieri</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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