LrgpV1, Main, Exploration, bibRecord, 000214

Esculin and its oligomer fractions inhibit adhesion and migration of U87 glioblastoma cells and in vitro angiogenesis

Identifieur interne : 000214 ( Main/Exploration ); précédent : 000213; suivant : 000215

Esculin and its oligomer fractions inhibit adhesion and migration of U87 glioblastoma cells and in vitro angiogenesis

Auteurs : Imen Mokdad-Bzeouich ; Hervé Kovacic [France] ; Kamel Ghedira ; Latifa Chebil [France] ; Mohamed Ghoul [France] ; Leila Chekir-Ghedira [Tunisie] ; José Luis [France]

Source :

Tumor Biology [ 1010-4283 ] ; 2015.

RBID : Hal:hal-01305592

Abstract

Cancer metastasis is the major cause of cancer-related death. Chemoprevention is defined as the use of natural or synthetic substances to prevent cancer formation or cancer progress. In the present study, we investigate the antitumor activity of esculin and its oligomer fractions in U87 glioblastoma cells. We showed that esculin and its oligomers reduced U87 cell growth in a dose dependent manner. They also inhibited cell adhesion to collagen IV and vitronectin by interfering with the function of their resp. receptors α2β1 and αvβ5 integrins. Furthermore, the tested samples were able to reduce migration of U87 cells towards another extracellular matrix fibronectin. Moreover, esculin and its oligomer fractions inhibited in vitro angiogenesis of endothelial cells (HMEC-1). In summary, our data provide the first evidence that esculin and its oligomer fractions are able to reduce adhesion, migration of glioblastoma cells and in vitro angiogenesis. Esculin and its oligomers may thus exert multi-target functions against cancer cells.

Url:

https://hal.archives-ouvertes.fr/hal-01305592

DOI: 10.1007/s13277-015-4209-1

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000434
to stream Hal, to step Curation: 000434
to stream Hal, to step Checkpoint: 000223
to stream Main, to step Merge: 000211
to stream Main, to step Curation: 000214

Le document en format XML

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<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Chekir Ghedira, Leila" sort="Chekir Ghedira, Leila" uniqKey="Chekir Ghedira L" first="Leila" last="Chekir-Ghedira">Leila Chekir-Ghedira</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-131523" status="INCOMING"><orgName>Unité de Pharmacognosie/Biologie Moléculaire 99/UR/07-03</orgName>
<desc><address><addrLine>Faculté de Pharmacie/Médecine Dentaire de Monastir, Rue Avicenne 5000 Monastir</addrLine>
<country key="TN"></country>
</address>
</desc>
<listRelation><relation active="#struct-323007" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-323007" type="direct"><org type="institution" xml:id="struct-323007" status="INCOMING"><orgName>Faculté de Pharmacie/Médecine Dentaire de Monastir</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Tunisie</country>
</affiliation>
</author>
<author><name sortKey="Luis, Jose" sort="Luis, Jose" uniqKey="Luis J" first="José" last="Luis">José Luis</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-46222" status="VALID"><idno type="RNSR">200816537V</idno>
<orgName>Centre de Recherches en Oncologies biologique et Oncopharmacologie</orgName>
<orgName type="acronym">CRO2</orgName>
<date type="start">2008</date>
<desc><address><addrLine>Faculté de Médecine et Faculté de Pharmacie - 27 Boulevard Jean Moulin 13385 Marseille cedex 05 </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cro2-timone.fr/</ref>
</desc>
<listRelation><relation active="#struct-5033" type="direct"></relation>
<relation active="#struct-198056" type="direct"></relation>
<relation active="#struct-300093" type="direct"></relation>
<relation name="INSERM U911" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-5033" type="direct"><org type="institution" xml:id="struct-5033" status="OLD"><idno type="IdRef">026402882</idno>
<orgName>Université de la Méditerranée - Aix-Marseille 2</orgName>
<date type="start">1969</date>
<date type="end">2011</date>
<desc><address><addrLine>58, boulevard Charles Livon - 13284 Marseille cedex 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univmed.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"><idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300093" type="direct"><org type="institution" xml:id="struct-300093" status="VALID"><orgName>CHU Hôpital de la Timone [APHM]</orgName>
<orgName type="acronym">TIMONE</orgName>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref>
</desc>
</org>
</tutelle>
<tutelle name="INSERM U911" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1007/s13277-015-4209-1</idno>
<series><title level="j">Tumor Biology</title>
<idno type="ISSN">1010-4283</idno>
<imprint><date type="datePub">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en">Cancer metastasis is the major cause of cancer-related death.  Chemoprevention is defined as the use of natural or synthetic substances to prevent cancer formation or cancer progress.  In the present study, we investigate the antitumor activity of esculin and its oligomer fractions in U87 glioblastoma cells.  We showed that esculin and its oligomers reduced U87 cell growth in a dose dependent manner.  They also inhibited cell adhesion to collagen IV and vitronectin by interfering with the function of their resp. receptors α2β1 and αvβ5 integrins.  Furthermore, the tested samples were able to reduce migration of U87 cells towards another extracellular matrix fibronectin.  Moreover, esculin and its oligomer fractions inhibited in vitro angiogenesis of endothelial cells (HMEC-1).  In summary, our data provide the first evidence that esculin and its oligomer fractions are able to reduce adhesion, migration of glioblastoma cells and in vitro angiogenesis.  Esculin and its oligomers may thus exert multi-target functions against cancer cells. </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Tunisie</li>
</country>
<region><li>Grand Est</li>
<li>Lorraine (région)</li>
<li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
<li>Metz</li>
<li>Nancy</li>
</settlement>
<orgName><li>Université d'Aix-Marseille</li>
<li>Université de Lorraine</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Ghedira, Kamel" sort="Ghedira, Kamel" uniqKey="Ghedira K" first="Kamel" last="Ghedira">Kamel Ghedira</name>
<name sortKey="Mokdad Bzeouich, Imen" sort="Mokdad Bzeouich, Imen" uniqKey="Mokdad Bzeouich I" first="Imen" last="Mokdad-Bzeouich">Imen Mokdad-Bzeouich</name>
</noCountry>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Kovacic, Herve" sort="Kovacic, Herve" uniqKey="Kovacic H" first="Hervé" last="Kovacic">Hervé Kovacic</name>
</region>
<name sortKey="Chebil, Latifa" sort="Chebil, Latifa" uniqKey="Chebil L" first="Latifa" last="Chebil">Latifa Chebil</name>
<name sortKey="Ghoul, Mohamed" sort="Ghoul, Mohamed" uniqKey="Ghoul M" first="Mohamed" last="Ghoul">Mohamed Ghoul</name>
<name sortKey="Luis, Jose" sort="Luis, Jose" uniqKey="Luis J" first="José" last="Luis">José Luis</name>
</country>
<country name="Tunisie"><noRegion><name sortKey="Chekir Ghedira, Leila" sort="Chekir Ghedira, Leila" uniqKey="Chekir Ghedira L" first="Leila" last="Chekir-Ghedira">Leila Chekir-Ghedira</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Esculin and its oligomer fractions inhibit adhesion and migration of U87 glioblastoma cells and in vitro angiogenesis

Esculin and its oligomer fractions inhibit adhesion and migration of U87 glioblastoma cells and in vitro angiogenesis

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