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Increased risk of developing Parkinson's disease for patients with major affective disorder: a register study

Identifieur interne : 001695 ( Istex/Corpus ); précédent : 001694; suivant : 001696

Increased risk of developing Parkinson's disease for patients with major affective disorder: a register study

Auteurs : F. M. Nilsson ; L. V. Kessing ; T. G. Bolwig

Source :

RBID : ISTEX:DB13405B25CA34AA9641313B143858C385324196

English descriptors

Abstract

Objective:  To investigate whether patients with a diagnosis of affective disorder are at an increased risk of developing Parkinson's disease compared with medically ill control groups.

Url:
DOI: 10.1111/j.1600-0447.2001.00372.x

Links to Exploration step

ISTEX:DB13405B25CA34AA9641313B143858C385324196

Le document en format XML

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<hi rend="bold">Objective:</hi>
 To investigate whether patients with a diagnosis of affective disorder are at an increased risk of developing Parkinson's disease compared with medically ill control groups.</p>
<p>
<hi rend="bold">Method:</hi>
 By linkage of public hospital registers from 1977 to 1993, three study cohorts were identified: patients with affective disorder episodes (mania or depression) and patients with osteoarthritis or diabetes. Time to the first diagnosis of Parkinson's disease was estimated with the use of survival analysis.</p>
<p>
<hi rend="bold">Results:</hi>
 A total of 164 385 patients entered the study base. The risk of being given a diagnosis of Parkinson's disease was significantly increased for patients with affective disorder, odds ratio 2.2 (CI 95% 1.7–2.8) compared with osteoarthritis, and depressive disorders, odds ratio 2.2 (CI 95% 1.7–2.9) compared with osteoarthritis.</p>
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 This study supports the hypothesis of a common aetiology for major affective disorder and Parkinson's disease.</p>
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<correspondenceTo>Flemming Mørkeberg Nilsson, MD, Department of Psychiatry, O 6233, Rigshospitalet, Blegdamsvej 9, DK‐2100 Copenhagen Ø, Denmark</correspondenceTo>
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<title type="main">Increased risk of developing Parkinson's disease for patients with major affective disorder: a register study</title>
<title type="shortAuthors">Nilsson et al.</title>
<title type="short">Affective disorder and Parkinson's disease</title>
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<b>Objective:</b>
 To investigate whether patients with a diagnosis of affective disorder are at an increased risk of developing Parkinson's disease compared with medically ill control groups.</p>
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<b>Method:</b>
 By linkage of public hospital registers from 1977 to 1993, three study cohorts were identified: patients with affective disorder episodes (mania or depression) and patients with osteoarthritis or diabetes. Time to the first diagnosis of Parkinson's disease was estimated with the use of survival analysis.</p>
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<b>Results:</b>
 A total of 164 385 patients entered the study base. The risk of being given a diagnosis of Parkinson's disease was significantly increased for patients with affective disorder, odds ratio 2.2 (CI 95% 1.7–2.8) compared with osteoarthritis, and depressive disorders, odds ratio 2.2 (CI 95% 1.7–2.9) compared with osteoarthritis.</p>
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 This study supports the hypothesis of a common aetiology for major affective disorder and Parkinson's disease.</p>
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<abstract>Objective:  To investigate whether patients with a diagnosis of affective disorder are at an increased risk of developing Parkinson's disease compared with medically ill control groups.</abstract>
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<abstract>Results:  A total of 164 385 patients entered the study base. The risk of being given a diagnosis of Parkinson's disease was significantly increased for patients with affective disorder, odds ratio 2.2 (CI 95% 1.7–2.8) compared with osteoarthritis, and depressive disorders, odds ratio 2.2 (CI 95% 1.7–2.9) compared with osteoarthritis.</abstract>
<abstract>Conclusion:  This study supports the hypothesis of a common aetiology for major affective disorder and Parkinson's disease.</abstract>
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