Influence of Hypo and Hyperthermia on Disposition of Morphine
Identifieur interne : 001620 ( Istex/Corpus ); précédent : 001619; suivant : 001621Influence of Hypo and Hyperthermia on Disposition of Morphine
Auteurs : Mylarrao Bansinath ; Herman Turndorf ; Margarita M. PuigSource :
- The Journal of Clinical Pharmacology [ 0091-2700 ] ; 1988-09.
English descriptors
- KwdEn :
- Anesthesia, Anesthesiology, Anesthetic, Anesthetized dogs, Arterial pressure, Body temperature, Body temperatures, Bolus injection, Cardiovascular, Cardiovascular effects, Comparable plasma morphine concentrations, Current study, Diagnostic products corporation, Femoral vein, Higher levels, Hyperthermia, Hyperthermic, Hyperthermic levels body temperature time, Hypotensive effect, Hypothermia, Hypothermic, Hypothermic dogs, Hypothermic group, Inhalation, Inhalation anesthetics, Isoflurane anesthesia, Malignant hyperthermia, Morphine, Morphine administration, Morphine levels, Morphine sulfate, Morphine sulphate, Normothermic, Normothermic animals, Opiate, Percent decrease, Pharmacokinetic parameters, Pharmacokinetics, Plasma levels, Plasma morphine levels, Residence time, Sampling time, Significant differences, Steady state, Total body clearance, York university.
- Teeft :
- Anesthesia, Anesthesiology, Anesthetic, Anesthetized dogs, Arterial pressure, Body temperature, Body temperatures, Bolus injection, Cardiovascular, Cardiovascular effects, Comparable plasma morphine concentrations, Current study, Diagnostic products corporation, Femoral vein, Higher levels, Hyperthermia, Hyperthermic, Hyperthermic levels body temperature time, Hypotensive effect, Hypothermia, Hypothermic, Hypothermic dogs, Hypothermic group, Inhalation, Inhalation anesthetics, Isoflurane anesthesia, Malignant hyperthermia, Morphine, Morphine administration, Morphine levels, Morphine sulfate, Morphine sulphate, Normothermic, Normothermic animals, Opiate, Percent decrease, Pharmacokinetic parameters, Pharmacokinetics, Plasma levels, Plasma morphine levels, Residence time, Sampling time, Significant differences, Steady state, Total body clearance, York university.
Abstract
Using morphine as a prototype opiate anesthetic, the dispositional changes and cardiovascular effects during hypothermia (30°C) and hyperthermia (40°C) in dogs under isoflurane anesthesia was assessed. Single intravenous bolus injection of 1 mg/kg morphine resulted in a significant and sustained decrease in mean arterial pressure in hypothermic, but not in hyperthermic or normothermic (37°C) conditions. Hypothermic dogs showed significantly higher levels of morphine both in plasma and in cerebrospinal fluid. In contrast, hyperthermia did not affect these levels. Body temperature did not affect the t1/2α, however t1/2β and mean residence time were significantly increased while volume of distribution at steady state and total body clearance were decreased during hypothermia. The results provide evidence that hypothermia is likely to be associated with a sustained increase in opiate levels and might be associated with a enhanced side effects. The results suggests the need for a controlled clinical trial to assess the dose of opiate anesthetics during hypothermia.
Url:
DOI: 10.1002/j.1552-4604.1988.tb03229.x
Links to Exploration step
ISTEX:FDA675F11029F8CC99D5FB16C19DB9A7132A5781Le document en format XML
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Single intravenous bolus injection of 1 mg/kg morphine resulted in a significant and sustained decrease in mean arterial pressure in hypothermic, but not in hyperthermic or normothermic (37°C) conditions. Hypothermic dogs showed significantly higher levels of morphine both in plasma and in cerebrospinal fluid. In contrast, hyperthermia did not affect these levels. Body temperature did not affect the t1/2α, however t1/2β and mean residence time were significantly increased while volume of distribution at steady state and total body clearance were decreased during hypothermia. The results provide evidence that hypothermia is likely to be associated with a sustained increase in opiate levels and might be associated with a enhanced side effects. The results suggests the need for a controlled clinical trial to assess the dose of opiate anesthetics during hypothermia.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>hypothermia</json:string><json:string>morphine</json:string><json:string>opiate</json:string><json:string>hypothermic</json:string><json:string>hyperthermia</json:string><json:string>anesthesia</json:string><json:string>pharmacokinetics</json:string><json:string>normothermic</json:string><json:string>anesthesiology</json:string><json:string>hyperthermic</json:string><json:string>inhalation anesthetics</json:string><json:string>anesthetic</json:string><json:string>body temperature</json:string><json:string>plasma morphine levels</json:string><json:string>morphine levels</json:string><json:string>cardiovascular</json:string><json:string>inhalation</json:string><json:string>plasma levels</json:string><json:string>residence time</json:string><json:string>current study</json:string><json:string>bolus injection</json:string><json:string>pharmacokinetic parameters</json:string><json:string>arterial pressure</json:string><json:string>morphine sulphate</json:string><json:string>cardiovascular effects</json:string><json:string>sampling time</json:string><json:string>percent decrease</json:string><json:string>morphine sulfate</json:string><json:string>anesthetized dogs</json:string><json:string>hyperthermic levels body temperature time</json:string><json:string>higher levels</json:string><json:string>isoflurane anesthesia</json:string><json:string>femoral vein</json:string><json:string>hypotensive effect</json:string><json:string>malignant hyperthermia</json:string><json:string>diagnostic products corporation</json:string><json:string>normothermic animals</json:string><json:string>steady state</json:string><json:string>significant differences</json:string><json:string>hypothermic group</json:string><json:string>morphine administration</json:string><json:string>total body clearance</json:string><json:string>comparable plasma morphine concentrations</json:string><json:string>hypothermic dogs</json:string><json:string>body temperatures</json:string><json:string>york university</json:string></teeft></keywords><author><json:item><name>Mylarrao Bansinath PhD</name><affiliations><json:string>Department of Anesthesiology, New York University Medical Center, New York, New York.</json:string></affiliations></json:item><json:item><name>Herman Turndorf MD</name><affiliations><json:string>Department of Anesthesiology, New York University Medical Center, New York, New York.</json:string></affiliations></json:item><json:item><name>Dr. Puig MD, PhD</name><affiliations><json:string>Department of Anesthesiology, New York University Medical Center, New York, New York.</json:string><json:string>Department of Anesthesiology, New York University Medical Center, 550 First Avenue, New York, NY 10016.</json:string></affiliations></json:item></author><articleId><json:string>JCPH3229</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>miscellaneous</json:string></originalGenre><abstract>Using morphine as a prototype opiate anesthetic, the dispositional changes and cardiovascular effects during hypothermia (30°C) and hyperthermia (40°C) in dogs under isoflurane anesthesia was assessed. Single intravenous bolus injection of 1 mg/kg morphine resulted in a significant and sustained decrease in mean arterial pressure in hypothermic, but not in hyperthermic or normothermic (37°C) conditions. Hypothermic dogs showed significantly higher levels of morphine both in plasma and in cerebrospinal fluid. In contrast, hyperthermia did not affect these levels. Body temperature did not affect the t1/2α, however t1/2β and mean residence time were significantly increased while volume of distribution at steady state and total body clearance were decreased during hypothermia. The results provide evidence that hypothermia is likely to be associated with a sustained increase in opiate levels and might be associated with a enhanced side effects. 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Single intravenous bolus injection of 1 mg/kg morphine resulted in a significant and sustained decrease in mean arterial pressure in hypothermic, but not in hyperthermic or normothermic (37°C) conditions. Hypothermic dogs showed significantly higher levels of morphine both in plasma and in cerebrospinal fluid. In contrast, hyperthermia did not affect these levels. Body temperature did not affect the t<hi rend="subscript">1/2α</hi>, however t<hi rend="subscript">1/2β</hi> and mean residence time were significantly increased while volume of distribution at steady state and total body clearance were decreased during hypothermia. The results provide evidence that hypothermia is likely to be associated with a sustained increase in opiate levels and might be associated with a enhanced side effects. The results suggests the need for a controlled clinical trial to assess the dose of opiate anesthetics during hypothermia.</p></abstract><textClass><keywords rend="tocHeading1"><term>Central Nervous System Drugs</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/FDA675F11029F8CC99D5FB16C19DB9A7132A5781/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1002/(ISSN)1552-4604</doi><issn type="print">0091-2700</issn><issn type="electronic">1552-4604</issn><idGroup><id type="product" value="JCPH"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF CLINICAL PHARMACOLOGY">The Journal of Clinical Pharmacology</title></titleGroup></publicationMeta><publicationMeta level="part" position="09109"><doi origin="wiley">10.1002/jcph.1988.28.issue-9</doi><numberingGroup><numbering type="journalVolume" number="28">28</numbering><numbering type="journalIssue" number="9">9</numbering></numberingGroup><coverDate startDate="1988-09">September 1988</coverDate></publicationMeta><publicationMeta level="unit" type="miscellaneous" position="15" status="forIssue"><doi origin="wiley">10.1002/j.1552-4604.1988.tb03229.x</doi><idGroup><id type="unit" value="JCPH3229"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Central Nervous System Drugs</title></titleGroup><copyright>1988 American College of Clinical Pharmacology</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.2.0 mode:FullText" date="2013-03-06"></event><event type="firstOnline" date="2013-03-08"></event><event type="publishedOnlineFinalForm" date="2013-03-08"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-30"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="860">860</numbering><numbering type="pageLast" number="864">864</numbering></numberingGroup><correspondenceTo>Department of Anesthesiology, New York University Medical Center, 550 First Avenue, New York, NY 10016.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JCPH.JCPH3229.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="referenceTotal" number="32"></count><count type="linksCrossRef" number="4"></count></countGroup><titleGroup><title type="main">Influence of Hypo and Hyperthermia on Disposition of Morphine</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Mylarrao</givenNames><familyName>Bansinath</familyName><degrees>PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Herman</givenNames><familyName>Turndorf</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1" corresponding="yes"><personName><honorifics>Dr.</honorifics><givenNames>Margarita M.</givenNames><familyName>Puig</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Department of Anesthesiology, New York University Medical Center, New York, New York.</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Using morphine as a prototype opiate anesthetic, the dispositional changes and cardiovascular effects during hypothermia (30°C) and hyperthermia (40°C) in dogs under isoflurane anesthesia was assessed. Single intravenous bolus injection of 1 mg/kg morphine resulted in a significant and sustained decrease in mean arterial pressure in hypothermic, but not in hyperthermic or normothermic (37°C) conditions. Hypothermic dogs showed significantly higher levels of morphine both in plasma and in cerebrospinal fluid. In contrast, hyperthermia did not affect these levels. Body temperature did not affect the t<sub>1/2α</sub>, however t<sub>1/2β</sub> and mean residence time were significantly increased while volume of distribution at steady state and total body clearance were decreased during hypothermia. The results provide evidence that hypothermia is likely to be associated with a sustained increase in opiate levels and might be associated with a enhanced side effects. The results suggests the need for a controlled clinical trial to assess the dose of opiate anesthetics during hypothermia.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Influence of Hypo and Hyperthermia on Disposition of Morphine</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Influence of Hypo and Hyperthermia on Disposition of Morphine</title></titleInfo><name type="personal"><namePart type="given">Mylarrao</namePart><namePart type="family">Bansinath</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Anesthesiology, New York University Medical Center, New York, New York.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Herman</namePart><namePart type="family">Turndorf</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Anesthesiology, New York University Medical Center, New York, New York.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">Margarita M.</namePart><namePart type="family">Puig</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Anesthesiology, New York University Medical Center, New York, New York.</affiliation><affiliation>Correspondence address: Department of Anesthesiology, New York University Medical Center, 550 First Avenue, New York, NY 10016.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="miscellaneous" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1988-09</dateIssued><copyrightDate encoding="w3cdtf">1988</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">32</extent><extent unit="linksCrossRef">4</extent></physicalDescription><abstract lang="en">Using morphine as a prototype opiate anesthetic, the dispositional changes and cardiovascular effects during hypothermia (30°C) and hyperthermia (40°C) in dogs under isoflurane anesthesia was assessed. Single intravenous bolus injection of 1 mg/kg morphine resulted in a significant and sustained decrease in mean arterial pressure in hypothermic, but not in hyperthermic or normothermic (37°C) conditions. Hypothermic dogs showed significantly higher levels of morphine both in plasma and in cerebrospinal fluid. In contrast, hyperthermia did not affect these levels. Body temperature did not affect the t1/2α, however t1/2β and mean residence time were significantly increased while volume of distribution at steady state and total body clearance were decreased during hypothermia. The results provide evidence that hypothermia is likely to be associated with a sustained increase in opiate levels and might be associated with a enhanced side effects. The results suggests the need for a controlled clinical trial to assess the dose of opiate anesthetics during hypothermia.</abstract><relatedItem type="host"><titleInfo><title>The Journal of Clinical Pharmacology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0091-2700</identifier><identifier type="eISSN">1552-4604</identifier><identifier type="DOI">10.1002/(ISSN)1552-4604</identifier><identifier type="PublisherID">JCPH</identifier><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>860</start><end>864</end><total>5</total></extent></part></relatedItem><identifier type="istex">FDA675F11029F8CC99D5FB16C19DB9A7132A5781</identifier><identifier type="ark">ark:/67375/WNG-W1KFVM72-3</identifier><identifier type="DOI">10.1002/j.1552-4604.1988.tb03229.x</identifier><identifier type="ArticleID">JCPH3229</identifier><accessCondition type="use and reproduction" contentType="copyright">1988 American College of Clinical Pharmacology</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/FDA675F11029F8CC99D5FB16C19DB9A7132A5781/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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