LrgpV1, Istex, Corpus, bibRecord, 001565

The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB‐fold

Identifieur interne : 001565 ( Istex/Corpus ); précédent : 001564; suivant : 001566

The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB‐fold

Auteurs : Debanu Das ; Piotr Kozbial ; Gye Won Han ; Dennis Carlton ; Lukasz Jaroszewski ; Polat Abdubek ; Tamara Astakhova ; Herbert L. Axelrod ; Constantina Bakolitsa ; Connie Chen ; Hsiu-Ju Chiu ; Michelle Chiu ; Thomas Clayton ; Marc C. Deller ; Lian Duan ; Kyle Ellrott ; Marc-André Elsliger ; Dustin Ernst ; Carol L. Farr ; Julie Feuerhelm ; Anna Grzechnik ; Joanna C. Grant ; Kevin K. Jin ; Hope A. Johnson ; Heath E. Klock ; Mark W. Knuth ; S. Sri Krishna ; Abhinav Kumar ; David Marciano ; Daniel Mcmullan ; Mitchell D. Miller ; Andrew T. Morse ; Edward Nigoghossian ; Amanda Nopakun ; Linda Okach ; Silvya Oommachen ; Jessica Paulsen ; Christina Puckett ; Ron Reyes ; Christopher L. Rife ; Natasha Sefcovic ; Henry J. Tien ; Christine B. Trame ; Henry Van Den Bedem ; Dana Weekes ; Tiffany Wooten ; Qingping Xu ; Keith O. Hodgson ; John Wooley ; Ashley M. Deacon ; Adam Godzik ; Scott A. Lesley ; Ian A. Wilson

Source :

Acta Crystallographica Section F [ 1744-3091 ] ; 2010-10-01.

RBID : ISTEX:25D0DC6DD73A25529E07E135DB941042DDC779E9

English descriptors

Abstract

KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB‐fold and structurally similar to the bacterial Cpx‐pathway protein NlpE, single‐stranded DNA‐binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital‐acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB‐fold family.

Url:

https://api.istex.fr/document/25D0DC6DD73A25529E07E135DB941042DDC779E9/fulltext/pdf

DOI: 10.1107/S1744309109018168

Links to Exploration step

ISTEX:25D0DC6DD73A25529E07E135DB941042DDC779E9

Le document en format XML

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<sourceDesc><biblStruct><analytic><title level="a" type="main">The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from <hi rend="italic">Klebsiella pneumoniae</hi>
, reveals an OB‐fold</title>
<author><name sortKey="Das, Debanu" sort="Das, Debanu" uniqKey="Das D" first="Debanu" last="Das">Debanu Das</name>
</author>
<author><name sortKey="Kozbial, Piotr" sort="Kozbial, Piotr" uniqKey="Kozbial P" first="Piotr" last="Kozbial">Piotr Kozbial</name>
</author>
<author><name sortKey="Han, Gye Won" sort="Han, Gye Won" uniqKey="Han G" first="Gye Won" last="Han">Gye Won Han</name>
</author>
<author><name sortKey="Carlton, Dennis" sort="Carlton, Dennis" uniqKey="Carlton D" first="Dennis" last="Carlton">Dennis Carlton</name>
</author>
<author><name sortKey="Jaroszewski, Lukasz" sort="Jaroszewski, Lukasz" uniqKey="Jaroszewski L" first="Lukasz" last="Jaroszewski">Lukasz Jaroszewski</name>
</author>
<author><name sortKey="Abdubek, Polat" sort="Abdubek, Polat" uniqKey="Abdubek P" first="Polat" last="Abdubek">Polat Abdubek</name>
</author>
<author><name sortKey="Astakhova, Tamara" sort="Astakhova, Tamara" uniqKey="Astakhova T" first="Tamara" last="Astakhova">Tamara Astakhova</name>
</author>
<author><name sortKey="Axelrod, Herbert L" sort="Axelrod, Herbert L" uniqKey="Axelrod H" first="Herbert L." last="Axelrod">Herbert L. Axelrod</name>
</author>
<author><name sortKey="Bakolitsa, Constantina" sort="Bakolitsa, Constantina" uniqKey="Bakolitsa C" first="Constantina" last="Bakolitsa">Constantina Bakolitsa</name>
</author>
<author><name sortKey="Chen, Connie" sort="Chen, Connie" uniqKey="Chen C" first="Connie" last="Chen">Connie Chen</name>
</author>
<author><name sortKey="Chiu, Hsiu U" sort="Chiu, Hsiu U" uniqKey="Chiu H" first="Hsiu-Ju" last="Chiu">Hsiu-Ju Chiu</name>
</author>
<author><name sortKey="Chiu, Michelle" sort="Chiu, Michelle" uniqKey="Chiu M" first="Michelle" last="Chiu">Michelle Chiu</name>
</author>
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</author>
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</author>
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</author>
<author><name sortKey="Ellrott, Kyle" sort="Ellrott, Kyle" uniqKey="Ellrott K" first="Kyle" last="Ellrott">Kyle Ellrott</name>
</author>
<author><name sortKey="Elsliger, Marc Ndre" sort="Elsliger, Marc Ndre" uniqKey="Elsliger M" first="Marc-André" last="Elsliger">Marc-André Elsliger</name>
</author>
<author><name sortKey="Ernst, Dustin" sort="Ernst, Dustin" uniqKey="Ernst D" first="Dustin" last="Ernst">Dustin Ernst</name>
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<author><name sortKey="Farr, Carol L" sort="Farr, Carol L" uniqKey="Farr C" first="Carol L." last="Farr">Carol L. Farr</name>
</author>
<author><name sortKey="Feuerhelm, Julie" sort="Feuerhelm, Julie" uniqKey="Feuerhelm J" first="Julie" last="Feuerhelm">Julie Feuerhelm</name>
</author>
<author><name sortKey="Grzechnik, Anna" sort="Grzechnik, Anna" uniqKey="Grzechnik A" first="Anna" last="Grzechnik">Anna Grzechnik</name>
</author>
<author><name sortKey="Grant, Joanna C" sort="Grant, Joanna C" uniqKey="Grant J" first="Joanna C." last="Grant">Joanna C. Grant</name>
</author>
<author><name sortKey="Jin, Kevin K" sort="Jin, Kevin K" uniqKey="Jin K" first="Kevin K." last="Jin">Kevin K. Jin</name>
</author>
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</author>
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</author>
<author><name sortKey="Knuth, Mark W" sort="Knuth, Mark W" uniqKey="Knuth M" first="Mark W." last="Knuth">Mark W. Knuth</name>
</author>
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</author>
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</author>
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<author><name sortKey="Miller, Mitchell D" sort="Miller, Mitchell D" uniqKey="Miller M" first="Mitchell D." last="Miller">Mitchell D. Miller</name>
</author>
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</author>
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<author><name sortKey="Oommachen, Silvya" sort="Oommachen, Silvya" uniqKey="Oommachen S" first="Silvya" last="Oommachen">Silvya Oommachen</name>
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<author><name sortKey="Paulsen, Jessica" sort="Paulsen, Jessica" uniqKey="Paulsen J" first="Jessica" last="Paulsen">Jessica Paulsen</name>
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<author><name sortKey="Rife, Christopher L" sort="Rife, Christopher L" uniqKey="Rife C" first="Christopher L." last="Rife">Christopher L. Rife</name>
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<author><name sortKey="Sefcovic, Natasha" sort="Sefcovic, Natasha" uniqKey="Sefcovic N" first="Natasha" last="Sefcovic">Natasha Sefcovic</name>
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<author><name sortKey="Godzik, Adam" sort="Godzik, Adam" uniqKey="Godzik A" first="Adam" last="Godzik">Adam Godzik</name>
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<series><title level="j" type="main">Acta Crystallographica Section F</title>
<title level="j" type="alt">ACTA CRYSTALLOGRAPHICA F</title>
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<term>Acta</term>
<term>Acta cryst</term>
<term>Aromatic residues</term>
<term>Asymmetric unit</term>
<term>Biol</term>
<term>Cholera toxin</term>
<term>Coli</term>
<term>Coli nlpe</term>
<term>Coli prib</term>
<term>Cryst</term>
<term>Crystal structure</term>
<term>Crystallization solution</term>
<term>Danese</term>
<term>Data collection</term>
<term>Divergent member</term>
<term>Helix</term>
<term>Klebsiella pneumoniae</term>
<term>Krissinel henrick</term>
<term>Lipoprotein</term>
<term>Ltxxq motif</term>
<term>Lysis buffer</term>
<term>Menlo park</term>
<term>Monomer</term>
<term>National institute</term>
<term>National institutes</term>
<term>Nature struct</term>
<term>Nlpe</term>
<term>Nucleic acids</term>
<term>Oligonucleotide binding</term>
<term>Opportunistic pathogen</term>
<term>Other proteins</term>
<term>Other structures</term>
<term>Pneumoniae</term>
<term>Prib</term>
<term>Primer</term>
<term>Sequence identity</term>
<term>Shiga toxin</term>
<term>Signal peptide</term>
<term>Silhavy</term>
<term>Stanford synchrotron radiation lightsource</term>
<term>Static light</term>
<term>Structural communications</term>
<term>Structural genomics</term>
<term>Synthetase</term>
<term>Thermophilus synthetase</term>
<term>Toxin</term>
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<term>Cholera toxin</term>
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<term>Crystal structure</term>
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<term>Data collection</term>
<term>Divergent member</term>
<term>Helix</term>
<term>Klebsiella pneumoniae</term>
<term>Krissinel henrick</term>
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<term>National institute</term>
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<term>Nature struct</term>
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<term>Nucleic acids</term>
<term>Oligonucleotide binding</term>
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<term>Other proteins</term>
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<term>Prib</term>
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<term>Sequence identity</term>
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<term>Signal peptide</term>
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<term>Stanford synchrotron radiation lightsource</term>
<term>Static light</term>
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<front><div type="abstract" xml:lang="en">KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB‐fold and structurally similar to the bacterial Cpx‐pathway protein NlpE, single‐stranded DNA‐binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital‐acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB‐fold family.</div>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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<author xml:id="author-0001"><persName><forename type="first">Piotr</forename>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0002"><persName><forename type="first">Gye Won</forename>
<surname>Han</surname>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
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</author>
<author xml:id="author-0003"><persName><forename type="first">Dennis</forename>
<surname>Carlton</surname>
</persName>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
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</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0017"><persName><forename type="first">Dustin</forename>
<surname>Ernst</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0018"><persName><forename type="first">Carol L.</forename>
<surname>Farr</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0019"><persName><forename type="first">Julie</forename>
<surname>Feuerhelm</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0020"><persName><forename type="first">Anna</forename>
<surname>Grzechnik</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0021"><persName><forename type="first">Joanna C.</forename>
<surname>Grant</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0022"><persName><forename type="first">Kevin K.</forename>
<surname>Jin</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0023"><persName><forename type="first">Hope A.</forename>
<surname>Johnson</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0024"><persName><forename type="first">Heath E.</forename>
<surname>Klock</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0025"><persName><forename type="first">Mark W.</forename>
<surname>Knuth</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0026"><persName><forename type="first">S. Sri</forename>
<surname>Krishna</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0027"><persName><forename type="first">Abhinav</forename>
<surname>Kumar</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0028"><persName><forename type="first">David</forename>
<surname>Marciano</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0029"><persName><forename type="first">Daniel</forename>
<surname>McMullan</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0030"><persName><forename type="first">Mitchell D.</forename>
<surname>Miller</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0031"><persName><forename type="first">Andrew T.</forename>
<surname>Morse</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0032"><persName><forename type="first">Edward</forename>
<surname>Nigoghossian</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0033"><persName><forename type="first">Amanda</forename>
<surname>Nopakun</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0034"><persName><forename type="first">Linda</forename>
<surname>Okach</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0035"><persName><forename type="first">Silvya</forename>
<surname>Oommachen</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0036"><persName><forename type="first">Jessica</forename>
<surname>Paulsen</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0037"><persName><forename type="first">Christina</forename>
<surname>Puckett</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0038"><persName><forename type="first">Ron</forename>
<surname>Reyes</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0039"><persName><forename type="first">Christopher L.</forename>
<surname>Rife</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0040"><persName><forename type="first">Natasha</forename>
<surname>Sefcovic</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0041"><persName><forename type="first">Henry J.</forename>
<surname>Tien</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0042"><persName><forename type="first">Christine B.</forename>
<surname>Trame</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0043"><persName><forename type="first">Henry</forename>
<surname>Van Den Bedem</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0044"><persName><forename type="first">Dana</forename>
<surname>Weekes</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0045"><persName><forename type="first">Tiffany</forename>
<surname>Wooten</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0046"><persName><forename type="first">Qingping</forename>
<surname>Xu</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0047"><persName><forename type="first">Keith O.</forename>
<surname>Hodgson</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0048"><persName><forename type="first">John</forename>
<surname>Wooley</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0049"><persName><forename type="first">Ashley M.</forename>
<surname>Deacon</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0050"><persName><forename type="first">Adam</forename>
<surname>Godzik</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0051"><persName><forename type="first">Scott A.</forename>
<surname>Lesley</surname>
</persName>
<affiliation>
Joint Center for Structural Genomics, , USAStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USAProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, California, USADepartment of Molecular Biology, The Scripps Research Institute, La Jolla, California, USACenter for Research in Biological Systems, University of California, San Diego, La Jolla, California, USAProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, USAPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, California, USA<address><country key="US US US US US US US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0052"><persName><forename type="first">Ian A.</forename>
<surname>Wilson</surname>
</persName>
<affiliation>
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<profileDesc><abstract xml:lang="en" style="main"><p>KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by <hi rend="italic">Klebsiella pneumoniae</hi>
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 MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital‐acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB‐fold family.</p>
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<titleGroup><title type="main">The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from <i>Klebsiella pneumoniae</i>
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<abstractGroup><abstract type="main" xml:lang="en"><p>KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by <i>Klebsiella pneumoniae</i>
 MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB‐fold and structurally similar to the bacterial Cpx‐pathway protein NlpE, single‐stranded DNA‐binding (SSB) proteins and toxins. <i>K. pneumoniae</i>
 MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital‐acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB‐fold family.</p>
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<dateIssued encoding="w3cdtf">2010-10-01</dateIssued>
<edition>Received 16 April 2009, accepted 13 May 2009</edition>
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<abstract lang="en">KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB‐fold and structurally similar to the bacterial Cpx‐pathway protein NlpE, single‐stranded DNA‐binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital‐acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB‐fold family.</abstract>
<subject lang="en"><genre>keywords</genre>
<topic>lipoproteins</topic>
<topic>OB‐fold</topic>
<topic>NipE‐like protein</topic>
<topic>single‐stranded DNA‐binding proteins</topic>
<topic>toxins</topic>
<topic>BOF</topic>
<topic>human gut pathogens</topic>
<topic>structural genomics</topic>
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<identifier type="DOI">10.1111/(ISSN)1744-3091</identifier>
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<part><date>2010</date>
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<number>66</number>
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<accessCondition type="use and reproduction" contentType="copyright">© Das et al. 2010</accessCondition>
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The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB‐fold

The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB‐fold

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