Enduring increased risk of developing depression and mania in patients with dementia
Identifieur interne : 000D29 ( Istex/Corpus ); précédent : 000D28; suivant : 000D30Enduring increased risk of developing depression and mania in patients with dementia
Auteurs : F M Nilsson ; L V Kessing ; T M S Rensen ; P K Andersen ; T G BolwigSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2002-07.
English descriptors
- KwdEn :
- Acta psychiatr scand, Affective, Affective disorder, Affective disorders, Affective episode, Alcohol abuse, Bipolar, Bipolar disorder, Brain function, Cohort, Confidence interval, Control group, Control groups, DNHR, Danish National Hospital Register, DPCR, Danish Psychiatric Central Register, Danish county, Danish hospital, Danish registers, Demented patients, Dementia, Dementia diabetes osteoarthritis, Depressive, Depressive disorder, Depressive episode dementia diabetes osteoarthritis, Diabetes, Diabetes mellitus, Diabetic population, Disorder, Elderly people, Entire period, First discharge, Hospital admission, Initial diagnosis, Kessing, Last calendar period, Long term, Major affective disorders, Major depression, Major depressive disorder, Manic episode, Nilsson, Osteoarthritis, Other index diagnoses, Previous studies, Proper treatment, Prospective study, Reference group, Relative intensities, Risks models, Study cohorts, Substance abuse, Substance abuser, Survival analysis, Temporal relation, Vascular dementia, Vital importance, affective disorder, dementia, survival analysis.
- Teeft :
- Acta psychiatr scand, Affective, Affective disorder, Affective disorders, Affective episode, Alcohol abuse, Bipolar, Bipolar disorder, Brain function, Cohort, Confidence interval, Control group, Control groups, Danish county, Danish hospital, Danish registers, Demented patients, Dementia, Dementia diabetes osteoarthritis, Depressive, Depressive disorder, Depressive episode dementia diabetes osteoarthritis, Diabetes, Diabetes mellitus, Diabetic population, Disorder, Elderly people, Entire period, First discharge, Hospital admission, Initial diagnosis, Kessing, Last calendar period, Long term, Major affective disorders, Major depression, Major depressive disorder, Manic episode, Nilsson, Osteoarthritis, Other index diagnoses, Previous studies, Proper treatment, Prospective study, Reference group, Relative intensities, Risks models, Study cohorts, Substance abuse, Substance abuser, Survival analysis, Temporal relation, Vascular dementia, Vital importance.
Abstract
Objective: To investigate the time relation between dementia and major affective disorders (major depression and mania). Methods: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models. Results: Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life. Conclusions: Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.
Url:
DOI: 10.1136/jnnp.73.1.40
Links to Exploration step
ISTEX:9C56EBCD71D1850E0234C6B8F7109332CB02BAACLe document en format XML
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osteoarthritis</term><term>Depressive</term><term>Depressive disorder</term><term>Depressive episode dementia diabetes osteoarthritis</term><term>Diabetes</term><term>Diabetes mellitus</term><term>Diabetic population</term><term>Disorder</term><term>Elderly people</term><term>Entire period</term><term>First discharge</term><term>Hospital admission</term><term>Initial diagnosis</term><term>Kessing</term><term>Last calendar period</term><term>Long term</term><term>Major affective disorders</term><term>Major depression</term><term>Major depressive disorder</term><term>Manic episode</term><term>Nilsson</term><term>Osteoarthritis</term><term>Other index diagnoses</term><term>Previous studies</term><term>Proper treatment</term><term>Prospective study</term><term>Reference group</term><term>Relative intensities</term><term>Risks models</term><term>Study cohorts</term><term>Substance abuse</term><term>Substance abuser</term><term>Survival analysis</term><term>Temporal relation</term><term>Vascular dementia</term><term>Vital importance</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To investigate the time relation between dementia and major affective disorders (major depression and mania). Methods: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models. Results: Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life. Conclusions: Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.</div></front></TEI><istex><corpusName>bmj</corpusName><keywords><teeft><json:string>dementia</json:string><json:string>affective</json:string><json:string>osteoarthritis</json:string><json:string>cohort</json:string><json:string>substance abuse</json:string><json:string>affective disorder</json:string><json:string>bipolar</json:string><json:string>kessing</json:string><json:string>depressive</json:string><json:string>control groups</json:string><json:string>first discharge</json:string><json:string>demented patients</json:string><json:string>nilsson</json:string><json:string>diabetes</json:string><json:string>diabetes mellitus</json:string><json:string>bipolar disorder</json:string><json:string>affective episode</json:string><json:string>acta psychiatr scand</json:string><json:string>danish registers</json:string><json:string>relative intensities</json:string><json:string>prospective study</json:string><json:string>major affective disorders</json:string><json:string>long term</json:string><json:string>study cohorts</json:string><json:string>risks models</json:string><json:string>vascular dementia</json:string><json:string>proper treatment</json:string><json:string>affective disorders</json:string><json:string>other index diagnoses</json:string><json:string>vital importance</json:string><json:string>danish hospital</json:string><json:string>major depression</json:string><json:string>reference group</json:string><json:string>temporal relation</json:string><json:string>depressive disorder</json:string><json:string>dementia diabetes osteoarthritis</json:string><json:string>confidence interval</json:string><json:string>depressive episode dementia diabetes osteoarthritis</json:string><json:string>initial diagnosis</json:string><json:string>alcohol abuse</json:string><json:string>last calendar period</json:string><json:string>entire period</json:string><json:string>manic episode</json:string><json:string>major depressive disorder</json:string><json:string>hospital admission</json:string><json:string>previous studies</json:string><json:string>elderly people</json:string><json:string>survival analysis</json:string><json:string>control group</json:string><json:string>brain function</json:string><json:string>diabetic population</json:string><json:string>danish county</json:string><json:string>substance abuser</json:string><json:string>disorder</json:string></teeft></keywords><author><json:item><name>F M Nilsson</name><affiliations><json:string>Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</json:string><json:string>Department of Psychiatric Demography, University of Aarhus, Risskov, Denmark</json:string></affiliations></json:item><json:item><name>L V Kessing</name><affiliations><json:string>Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</json:string></affiliations></json:item><json:item><name>T M Sørensen</name><affiliations><json:string>Department of Biostatistics, University of Copenhagen</json:string></affiliations></json:item><json:item><name>P K Andersen</name><affiliations><json:string>Department of Biostatistics, University of Copenhagen</json:string></affiliations></json:item><json:item><name>T G Bolwig</name><affiliations><json:string>Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Memory disorders (neurology)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Memory disorders (psychiatry)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mood disorders (including depression)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Musculoskeletal syndromes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>affective disorder</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>survival analysis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DNHR, Danish National Hospital Register</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DPCR, Danish Psychiatric Central Register</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Objective: To investigate the time relation between dementia and major affective disorders (major depression and mania). Methods: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models. Results: Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life. Conclusions: Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.</abstract><qualityIndicators><score>5.136</score><pdfVersion>1.1</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>9</keywordCount><abstractCharCount>917</abstractCharCount><pdfWordCount>3480</pdfWordCount><pdfCharCount>22958</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>138</abstractWordCount></qualityIndicators><title>Enduring increased risk of developing depression and mania in patients with dementia</title><pmid><json:string>12082043</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Journal of Neurology, Neurosurgery & Psychiatry</title><language><json:string>unknown</json:string></language><issn><json:string>0022-3050</json:string></issn><eissn><json:string>1468-330X</json:string></eissn><volume>73</volume><issue>1</issue><pages><first>40</first></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>social science</json:string><json:string>psychiatry</json:string><json:string>science</json:string><json:string>surgery</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix><inist><json:string>sciences humaines et sociales</json:string></inist></categories><publicationDate>2002</publicationDate><copyrightDate>2002</copyrightDate><doi><json:string>10.1136/jnnp.73.1.40</json:string></doi><id>9C56EBCD71D1850E0234C6B8F7109332CB02BAAC</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/9C56EBCD71D1850E0234C6B8F7109332CB02BAAC/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/9C56EBCD71D1850E0234C6B8F7109332CB02BAAC/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/9C56EBCD71D1850E0234C6B8F7109332CB02BAAC/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Enduring increased risk of developing depression and mania in patients with dementia</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://publisher-list.data.istex.fr">BMJ Publishing Group Ltd</publisher><availability><licence><p>Copyright 2002 Journal of Neurology Neurosurgery and Psychiatry</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</p></availability><date>2002-07-01</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Correspondence to:
Dr Flemming M Nilsson, Department of Psychiatry, O 6233 Neuroscience Centre, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen Ø, Denmark;
fmn@rh.dk</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Enduring increased risk of developing depression and mania in patients with dementia</title><author xml:id="author-0000"><persName><forename type="first">F M</forename><surname>Nilsson</surname></persName><affiliation>Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</affiliation><affiliation>Department of Psychiatric Demography, University of Aarhus, Risskov, Denmark</affiliation></author><author xml:id="author-0001"><persName><forename type="first">L V</forename><surname>Kessing</surname></persName><affiliation>Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</affiliation></author><author xml:id="author-0002"><persName><forename type="first">T M</forename><surname>Sørensen</surname></persName><affiliation>Department of Biostatistics, University of Copenhagen</affiliation></author><author xml:id="author-0003"><persName><forename type="first">P K</forename><surname>Andersen</surname></persName><affiliation>Department of Biostatistics, University of Copenhagen</affiliation></author><author xml:id="author-0004"><persName><forename type="first">T G</forename><surname>Bolwig</surname></persName><affiliation>Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</affiliation></author><idno type="istex">9C56EBCD71D1850E0234C6B8F7109332CB02BAAC</idno><idno type="ark">ark:/67375/NVC-MH0C59DP-D</idno><idno type="DOI">10.1136/jnnp.73.1.40</idno><idno type="href">jnnp-73-40.pdf</idno><idno type="PMID">12082043</idno><idno type="local">0730040</idno></analytic><monogr><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="pISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><idno type="PublisherID-hwp">jnnp</idno><idno type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2002-07"></date><biblScope unit="volume">73</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="40">40</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2002-07-01</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Objective: To investigate the time relation between dementia and major affective disorders (major depression and mania). Methods: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models. Results: Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life. Conclusions: Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>KWD</head><item><term>affective disorder</term></item><item><term>dementia</term></item><item><term>survival analysis</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>ABR</head><item><term>DNHR, Danish National Hospital Register</term></item><item><term>DPCR, Danish Psychiatric Central Register</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Memory disorders (neurology)</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Memory disorders (psychiatry)</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Mood disorders (including depression)</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>Musculoskeletal syndromes</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2002-07-01">Created</change><change when="2002-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/9C56EBCD71D1850E0234C6B8F7109332CB02BAAC/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">jnnp</journal-id><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-title>Journal of Neurology, Neurosurgery & Psychiatry</journal-title><abbrev-journal-title abbrev-type="publisher">J Neurol Neurosurg Psychiatry</abbrev-journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="other">0730040</article-id><article-id pub-id-type="other">jnnp;73/1/40</article-id><article-id pub-id-type="doi">10.1136/jnnp.73.1.40</article-id><article-id pub-id-type="pmid">12082043</article-id><article-id pub-id-type="other">40</article-id><article-id pub-id-type="other">jnnp.73.1.40</article-id><article-categories><subj-group subj-group-type="heading"><subject content-type="original">Papers</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Memory disorders (neurology)</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Memory disorders (psychiatry)</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Mood disorders (including depression)</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Musculoskeletal syndromes</subject></subj-group></article-categories><title-group><article-title>Enduring increased risk of developing depression and mania in patients with dementia</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Nilsson</surname><given-names>F M</given-names></name><xref rid="AFF1">1</xref><xref rid="AFF3">3</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kessing</surname><given-names>L V</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Sørensen</surname><given-names>T M</given-names></name><xref rid="AFF2">2</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Andersen</surname><given-names>P K</given-names></name><xref rid="AFF2">2</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Bolwig</surname><given-names>T G</given-names></name><xref rid="AFF1">1</xref></contrib><aff id="AFF1"><label>1</label>Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark </aff><aff id="AFF2"><label>2</label>Department of Biostatistics, University of Copenhagen </aff><aff id="AFF3"><label>3</label>Department of Psychiatric Demography, University of Aarhus, Risskov, Denmark</aff></contrib-group><author-notes><corresp>Correspondence to:
Dr Flemming M Nilsson, Department of Psychiatry, O 6233 Neuroscience Centre, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen Ø, Denmark;
<ext-link xlink:href="fmn@rh.dk" ext-link-type="email" xlink:type="simple">fmn@rh.dk</ext-link></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2002</year></pub-date><pub-date pub-type="epub"><day>1</day><month>7</month><year>2002</year></pub-date><volume>73</volume><volume-id pub-id-type="other">73</volume-id><volume-id pub-id-type="other">73</volume-id><issue>1</issue><issue-id pub-id-type="other">jnnp;73/1</issue-id><issue-id pub-id-type="other">1</issue-id><issue-id pub-id-type="other">73/1</issue-id><fpage>40</fpage><history><date date-type="accepted"><day>22</day><month>03</month><year>2002</year></date><date date-type="received"><day>12</day><month>11</month><year>2001</year></date><date date-type="rev-recd"><day>15</day><month>03</month><year>2002</year></date></history><permissions><copyright-statement>Copyright 2002 Journal of Neurology Neurosurgery and Psychiatry</copyright-statement><copyright-year>2002</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jnnp-73-40.pdf"></self-uri><abstract xml:lang="en"><p><bold>Objective:</bold> To investigate the time relation between dementia and major affective disorders (major depression and mania).</p><p><bold>Methods:</bold> Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models.</p><p><bold>Results:</bold> Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life.</p><p><bold>Conclusions:</bold> Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.</p></abstract><kwd-group kwd-group-type="KWD" xml:lang="en"><kwd>affective disorder</kwd><kwd>dementia</kwd><kwd>survival analysis</kwd></kwd-group><kwd-group kwd-group-type="ABR" xml:lang="en"><kwd>DNHR, Danish National Hospital Register</kwd><kwd>DPCR, Danish Psychiatric Central Register</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Enduring increased risk of developing depression and mania in patients with dementia</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Enduring increased risk of developing depression and mania in patients with dementia</title></titleInfo><name type="personal"><namePart type="given">F M</namePart><namePart type="family">Nilsson</namePart><affiliation>Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</affiliation><affiliation>Department of Psychiatric Demography, University of Aarhus, Risskov, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L V</namePart><namePart type="family">Kessing</namePart><affiliation>Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T M</namePart><namePart type="family">Sørensen</namePart><affiliation>Department of Biostatistics, University of Copenhagen</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P K</namePart><namePart type="family">Andersen</namePart><affiliation>Department of Biostatistics, University of Copenhagen</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T G</namePart><namePart type="family">Bolwig</namePart><affiliation>Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2002-07</dateIssued><dateCreated encoding="w3cdtf">2002-07-01</dateCreated><copyrightDate encoding="w3cdtf">2002</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Objective: To investigate the time relation between dementia and major affective disorders (major depression and mania). Methods: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models. Results: Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life. Conclusions: Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.</abstract><note type="author-notes">Correspondence to:
Dr Flemming M Nilsson, Department of Psychiatry, O 6233 Neuroscience Centre, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen Ø, Denmark;
fmn@rh.dk</note><subject lang="en"><genre>KWD</genre><topic>affective disorder</topic><topic>dementia</topic><topic>survival analysis</topic></subject><subject lang="en"><genre>ABR</genre><topic>DNHR, Danish National Hospital Register</topic><topic>DPCR, Danish Psychiatric Central Register</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neurology, Neurosurgery & Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol Neurosurg Psychiatry</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>hwp-journal-coll</genre><topic>Memory disorders (neurology)</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Memory disorders (psychiatry)</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Mood disorders (including depression)</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Musculoskeletal syndromes</topic></subject><identifier type="ISSN">0022-3050</identifier><identifier type="eISSN">1468-330X</identifier><identifier type="PublisherID-hwp">jnnp</identifier><identifier type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</identifier><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>40</start></extent></part></relatedItem><identifier type="istex">9C56EBCD71D1850E0234C6B8F7109332CB02BAAC</identifier><identifier type="ark">ark:/67375/NVC-MH0C59DP-D</identifier><identifier type="DOI">10.1136/jnnp.73.1.40</identifier><identifier type="href">jnnp-73-40.pdf</identifier><identifier type="PMID">12082043</identifier><identifier type="local">0730040</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright 2002 Journal of Neurology Neurosurgery and Psychiatry</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</recordContentSource><recordOrigin>Copyright 2002 Journal of Neurology Neurosurgery and Psychiatry</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/9C56EBCD71D1850E0234C6B8F7109332CB02BAAC/metadata/json</uri></json:item></metadata><annexes><json:item><extension>jpeg</extension><original>true</original><mimetype>image/jpeg</mimetype><uri>https://api.istex.fr/document/9C56EBCD71D1850E0234C6B8F7109332CB02BAAC/annexes/jpeg</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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