LrgpV1, Hal, Curation, bibRecord, 000536

Functionalized silica-based nanoparticles for photodynamic therapy,

Identifieur interne : 000536 ( Hal/Curation ); précédent : 000535; suivant : 000537

Functionalized silica-based nanoparticles for photodynamic therapy,

Auteurs : Pierre Couleaud [France] ; Denise Bechet [France] ; Régis Vanderesse [France] ; Muriel Barberi-Heyob [France] ; Anne-Charlotte Faure [France] ; Stéphane Roux [France] ; Olivier Tillement [France] ; Sabine Porhel [France] ; François Guillemin [France] ; Céline Frochot [France]

Source :

Nanomedicine [ 1743-5889 ] ; 2011-08.

RBID : Hal:hal-00585155

Abstract

Aim: The strategy developed aims to favor the vascular effect of photodynamic therapy by targeting tumor-associated vascularization using peptide-functionalized nanoparticles. We previously described the conjugation of a photosensitizer to a peptide targeting neuropilin-1 overexpressed in tumor angiogenic vessels. Materials & Methods: In this study, we have designed and photophysically characterized a multifunctional nanoparticle consisting of a surface-localized tumor vasculature targeting peptides and encapsulated photodynamic therapy and imaging agents. Results & Conclusion: The elaboration of these multifunctional silica-based nanoparticles is reported. Nanoparticles functionalized with approximately 4.2 peptides bound to recombinant neuropilin-1 protein. Nanoparticles conferred photosensitivity to cells overexpressing neuropilin-1, providing evidence that the chlorin grafted within the nanoparticle matrix can be photoactivated to yield photocytotoxic effects in vitro.

Url:

https://hal.archives-ouvertes.fr/hal-00585155

DOI: 10.2217/nnm.11.31

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Le document en format XML

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<idno type="DOI">10.2217/nnm.11.31</idno>
<series><title level="j">Nanomedicine</title>
<idno type="ISSN">1743-5889</idno>
<imprint><date type="datePub">2011-08</date>
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<front><div type="abstract" xml:lang="en">Aim: The strategy developed aims to favor the vascular effect of photodynamic therapy by targeting tumor-associated vascularization using peptide-functionalized nanoparticles. We previously described the conjugation of a photosensitizer to a peptide targeting neuropilin-1 overexpressed in tumor angiogenic vessels. Materials & Methods: In this study, we have designed and photophysically characterized a multifunctional nanoparticle consisting of a surface-localized tumor vasculature targeting peptides and encapsulated photodynamic therapy and imaging agents. Results & Conclusion: The elaboration of these multifunctional silica-based nanoparticles is reported. Nanoparticles functionalized with approximately 4.2 peptides bound to recombinant neuropilin-1 protein. Nanoparticles conferred photosensitivity to cells overexpressing neuropilin-1, providing evidence that the chlorin grafted within the nanoparticle matrix can be photoactivated to yield photocytotoxic effects in vitro.</div>
</front>
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<hal api="V3"><titleStmt><title xml:lang="en">Functionalized silica-based nanoparticles for photodynamic therapy,</title>
<author role="aut"><persName><forename type="first">Pierre</forename>
<surname>Couleaud</surname>
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<email></email>
<idno type="halauthor">354053</idno>
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</author>
<author role="aut"><persName><forename type="first">Denise</forename>
<surname>Bechet</surname>
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<email></email>
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<author role="aut"><persName><forename type="first">Régis</forename>
<surname>Vanderesse</surname>
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<email></email>
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<author role="aut"><persName><forename type="first">Muriel</forename>
<surname>Barberi-Heyob</surname>
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<email></email>
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<email></email>
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<author role="aut"><persName><forename type="first">Stéphane</forename>
<forename type="middle">G.</forename>
<surname>Roux</surname>
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<author role="aut"><persName><forename type="first">François</forename>
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<editor role="depositor"><persName><forename>Didier</forename>
<surname>Wolf</surname>
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<email>Didier.Wolf@univ-lorraine.fr</email>
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<editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2011-04-11 20:10:35</date>
<date type="whenModified">2016-06-23 01:11:37</date>
<date type="whenReleased">2011-04-11 20:10:35</date>
<date type="whenProduced">2011-08</date>
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<name key="114907"><persName><forename>Didier</forename>
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<email>Didier.Wolf@univ-lorraine.fr</email>
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<idno type="halId">hal-00585155</idno>
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<idno type="halBibtex">couleaud:hal-00585155</idno>
<idno type="halRefHtml">Nanomedicine, Future Medicine, 2011, 6 (6), pp.995-1009. <10.2217/nnm.11.31></idno>
<idno type="halRef">Nanomedicine, Future Medicine, 2011, 6 (6), pp.995-1009. <10.2217/nnm.11.31></idno>
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<idno type="stamp" n="CRAN">Centre de Recherche en Automatique de Nancy</idno>
<idno type="stamp" n="LMT" p="UPMC">Laboratoire de mécanique et technologie</idno>
<idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno>
<idno type="stamp" n="LRGP-UL">LRGP</idno>
<idno type="stamp" n="INPL">Institut National Polytechnique de Lorraine</idno>
<idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
<idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
<idno type="stamp" n="ENS-CACHAN">Ecole Normale Supérieure de Cachan</idno>
<idno type="stamp" n="VAUTRIN" p="FNCLCC">Centre Alexis Vautrin</idno>
<idno type="stamp" n="FNCLCC" p="INSERM">UNICANCER</idno>
</seriesStmt>
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<note type="popular" n="0">No</note>
<note type="peer" n="1">Yes</note>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Functionalized silica-based nanoparticles for photodynamic therapy,</title>
<author role="aut"><persName><forename type="first">Pierre</forename>
<surname>Couleaud</surname>
</persName>
<idno type="halAuthorId">354053</idno>
<affiliation ref="#struct-211875"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Denise</forename>
<surname>Bechet</surname>
</persName>
<idno type="halAuthorId">200146</idno>
<affiliation ref="#struct-101696"></affiliation>
<affiliation ref="#struct-1001"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Régis</forename>
<surname>Vanderesse</surname>
</persName>
<idno type="halAuthorId">128649</idno>
<affiliation ref="#struct-439403"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Muriel</forename>
<surname>Barberi-Heyob</surname>
</persName>
<idno type="halAuthorId">89501</idno>
<affiliation ref="#struct-101696"></affiliation>
<affiliation ref="#struct-1001"></affiliation>
<affiliation ref="#struct-73720"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Anne-Charlotte</forename>
<surname>Faure</surname>
</persName>
<idno type="halAuthorId">340883</idno>
<affiliation ref="#struct-174"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Stéphane</forename>
<forename type="middle">G.</forename>
<surname>Roux</surname>
</persName>
<idno type="halAuthorId">1361</idno>
<affiliation ref="#struct-1306"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Olivier</forename>
<surname>Tillement</surname>
</persName>
<idno type="halAuthorId">144378</idno>
<affiliation ref="#struct-174"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Sabine</forename>
<surname>Porhel</surname>
</persName>
<idno type="halAuthorId">554198</idno>
<affiliation ref="#struct-211875"></affiliation>
</author>
<author role="aut"><persName><forename type="first">François</forename>
<surname>Guillemin</surname>
</persName>
<idno type="idHal">francois-guillemin</idno>
<idno type="halAuthorId">89500</idno>
<affiliation ref="#struct-101696"></affiliation>
<affiliation ref="#struct-1001"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Céline</forename>
<surname>Frochot</surname>
</persName>
<idno type="halAuthorId">133064</idno>
<affiliation ref="#struct-211875"></affiliation>
<affiliation ref="#struct-73720"></affiliation>
</author>
</analytic>
<monogr><idno type="halJournalId" status="VALID">17282</idno>
<idno type="issn">1743-5889</idno>
<idno type="eissn">1748-6963</idno>
<title level="j">Nanomedicine</title>
<imprint><publisher>Future Medicine</publisher>
<biblScope unit="volume">6</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="pp">995-1009</biblScope>
<date type="datePub">2011-08</date>
</imprint>
</monogr>
<idno type="doi">10.2217/nnm.11.31</idno>
</biblStruct>
</sourceDesc>
<profileDesc><langUsage><language ident="en">English</language>
</langUsage>
<textClass><classCode scheme="halDomain" n="sdv.ib">Life Sciences [q-bio]/Bioengineering</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en">Aim: The strategy developed aims to favor the vascular effect of photodynamic therapy by targeting tumor-associated vascularization using peptide-functionalized nanoparticles. We previously described the conjugation of a photosensitizer to a peptide targeting neuropilin-1 overexpressed in tumor angiogenic vessels. Materials & Methods: In this study, we have designed and photophysically characterized a multifunctional nanoparticle consisting of a surface-localized tumor vasculature targeting peptides and encapsulated photodynamic therapy and imaging agents. Results & Conclusion: The elaboration of these multifunctional silica-based nanoparticles is reported. Nanoparticles functionalized with approximately 4.2 peptides bound to recombinant neuropilin-1 protein. Nanoparticles conferred photosensitivity to cells overexpressing neuropilin-1, providing evidence that the chlorin grafted within the nanoparticle matrix can be photoactivated to yield photocytotoxic effects in vitro.</abstract>
</profileDesc>
</hal>
</record>

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Functionalized silica-based nanoparticles for photodynamic therapy,

Functionalized silica-based nanoparticles for photodynamic therapy,

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