LrgpV1, Hal, Checkpoint, bibRecord, 000075

Nanoparticles for radiation therapy enhancement: the key parameters

Identifieur interne : 000075 ( Hal/Checkpoint ); précédent : 000074; suivant : 000076

Nanoparticles for radiation therapy enhancement: the key parameters

Auteurs : Paul Retif [France] ; Sophie Pinel [France] ; Magali Toussaint [France] ; Céline Frochot [France] ; Rima Chouikrat [France] ; Thierry Bastogne [France] ; Muriel Barberi-Heyob [France]

Source :

Theranostics [ 1838-7640 ] ; 2015-09.

RBID : Hal:hal-01174788

Descripteurs français

Wicri :
- topic : Cancer, Radiobiologie.

English descriptors

mix :
- Cancer, Nanoparticles, Photodynamic therapy, Radiation therapy, Radiobiology, Radiosensitization.

Abstract

This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.

Url:

https://hal.archives-ouvertes.fr/hal-01174788

DOI: 10.7150/thno.11642

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000810
to stream Hal, to step Curation: 000810

Links to Exploration step

Hal:hal-01174788

Le document en format XML

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<abstract xml:lang="en">This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.</abstract>
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Nanoparticles for radiation therapy enhancement: the key parameters

Nanoparticles for radiation therapy enhancement: the key parameters

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