Cytokine/Chemokine HLDA8 Workshop panel report: analysis of receptors on lymphocytes from cord blood, normal and asthmatic subjects, and HIV positive patients.
Identifieur interne : 000163 ( PubMed/Corpus ); précédent : 000162; suivant : 000164Cytokine/Chemokine HLDA8 Workshop panel report: analysis of receptors on lymphocytes from cord blood, normal and asthmatic subjects, and HIV positive patients.
Auteurs : Maria Paola Loria ; Porzia Dambra ; Laura Capuzzimati ; Adriana Dell'Osso ; Rossella Crollo ; Giacoma De Tullio ; Elena Lasaracina ; Alfredo TursiSource :
- Cellular immunology [ 0008-8749 ]
English descriptors
- KwdEn :
- Acquired Immunodeficiency Syndrome (metabolism), Adult, Antibodies, Monoclonal, Asthma (metabolism), Fetal Blood (metabolism), HIV Infections (metabolism), Humans, Lymphocytes (metabolism), Receptors, CCR5 (metabolism), Receptors, CCR7, Receptors, CXCR4 (metabolism), Receptors, Chemokine (metabolism), Receptors, Cytokine (metabolism).
- MESH :
- chemical , metabolism : Receptors, CCR5, Receptors, CXCR4, Receptors, Chemokine, Receptors, Cytokine.
- chemical : Antibodies, Monoclonal, Receptors, CCR7.
- metabolism : Acquired Immunodeficiency Syndrome, Asthma, Fetal Blood, HIV Infections, Lymphocytes.
- Adult, Humans.
Abstract
Chemokines and cytokines are involved in many processes, both physiological and pathological, particularly the recruitment, differentiation, activation, and proliferation of immune cells taking part in ontogenesis, inflammation, and cancer. It was assumed that chemokines and cytokines receptors are expressed in a regulated manner by human lymphocytes during ontogeny and later on, under the environmental stimulation of antigens they contribute to organogenesis, angiogenesis, and tissue remodeling, as well as modulating leukocyte effector functions. Using monoclonal antibodies classified by the Cytokine/Chemokine section of the 8th International Workshop on Human Leukocyte Differentiation Antigens, we analyzed human lymphocytes in blood samples drawn from the umbilical cord, normal adults, allergic and non-allergic asthma patients, HIV infected, and AIDS positive subjects. The main differences noted between adult and cord blood lymphocytes were related to CCR7 and CXCR4 receptors, which were more strongly expressed on cord blood lymphocytes, confirming the important role of these chemokines during development of the immune system. As with the HIV, CXCR4, and CCR5 co-receptors, we found no differences in CXCR4 expression between HIV and AIDS patients. However CCR5 was more strongly expressed in AIDS patients, which is likely to be associated with the evolution of disease. Further studies are needed to gain a better understanding of the functions of these molecules in the underlying pathogenesis of many diseases and to probe the use of the chemokine receptors as targets for therapeutic intervention.
DOI: 10.1016/j.cellimm.2005.08.015
PubMed: 16185672
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first="Adriana" last="Dell'Osso">Adriana Dell'Osso</name></author><author><name sortKey="Crollo, Rossella" sort="Crollo, Rossella" uniqKey="Crollo R" first="Rossella" last="Crollo">Rossella Crollo</name></author><author><name sortKey="De Tullio, Giacoma" sort="De Tullio, Giacoma" uniqKey="De Tullio G" first="Giacoma" last="De Tullio">Giacoma De Tullio</name></author><author><name sortKey="Lasaracina, Elena" sort="Lasaracina, Elena" uniqKey="Lasaracina E" first="Elena" last="Lasaracina">Elena Lasaracina</name></author><author><name sortKey="Tursi, Alfredo" sort="Tursi, Alfredo" uniqKey="Tursi A" first="Alfredo" last="Tursi">Alfredo Tursi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2005 Jul-Aug</MedlineDate></PubDate></date><idno type="doi">10.1016/j.cellimm.2005.08.015</idno><idno type="RBID">pubmed:16185672</idno><idno type="pmid">16185672</idno><idno type="wicri:Area/PubMed/Corpus">000163</idno><idno 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Capuzzimati</name></author><author><name sortKey="Dell Osso, Adriana" sort="Dell Osso, Adriana" uniqKey="Dell Osso A" first="Adriana" last="Dell'Osso">Adriana Dell'Osso</name></author><author><name sortKey="Crollo, Rossella" sort="Crollo, Rossella" uniqKey="Crollo R" first="Rossella" last="Crollo">Rossella Crollo</name></author><author><name sortKey="De Tullio, Giacoma" sort="De Tullio, Giacoma" uniqKey="De Tullio G" first="Giacoma" last="De Tullio">Giacoma De Tullio</name></author><author><name sortKey="Lasaracina, Elena" sort="Lasaracina, Elena" uniqKey="Lasaracina E" first="Elena" last="Lasaracina">Elena Lasaracina</name></author><author><name sortKey="Tursi, Alfredo" sort="Tursi, Alfredo" uniqKey="Tursi A" first="Alfredo" last="Tursi">Alfredo Tursi</name></author></analytic><series><title level="j">Cellular immunology</title><idno type="ISSN">0008-8749</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acquired Immunodeficiency Syndrome (metabolism)</term><term>Adult</term><term>Antibodies, Monoclonal</term><term>Asthma (metabolism)</term><term>Fetal Blood (metabolism)</term><term>HIV Infections (metabolism)</term><term>Humans</term><term>Lymphocytes (metabolism)</term><term>Receptors, CCR5 (metabolism)</term><term>Receptors, CCR7</term><term>Receptors, CXCR4 (metabolism)</term><term>Receptors, Chemokine (metabolism)</term><term>Receptors, Cytokine (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, CCR5</term><term>Receptors, CXCR4</term><term>Receptors, Chemokine</term><term>Receptors, Cytokine</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Receptors, CCR7</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Acquired Immunodeficiency Syndrome</term><term>Asthma</term><term>Fetal Blood</term><term>HIV Infections</term><term>Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chemokines and cytokines are involved in many processes, both physiological and pathological, particularly the recruitment, differentiation, activation, and proliferation of immune cells taking part in ontogenesis, inflammation, and cancer. It was assumed that chemokines and cytokines receptors are expressed in a regulated manner by human lymphocytes during ontogeny and later on, under the environmental stimulation of antigens they contribute to organogenesis, angiogenesis, and tissue remodeling, as well as modulating leukocyte effector functions. Using monoclonal antibodies classified by the Cytokine/Chemokine section of the 8th International Workshop on Human Leukocyte Differentiation Antigens, we analyzed human lymphocytes in blood samples drawn from the umbilical cord, normal adults, allergic and non-allergic asthma patients, HIV infected, and AIDS positive subjects. The main differences noted between adult and cord blood lymphocytes were related to CCR7 and CXCR4 receptors, which were more strongly expressed on cord blood lymphocytes, confirming the important role of these chemokines during development of the immune system. As with the HIV, CXCR4, and CCR5 co-receptors, we found no differences in CXCR4 expression between HIV and AIDS patients. However CCR5 was more strongly expressed in AIDS patients, which is likely to be associated with the evolution of disease. Further studies are needed to gain a better understanding of the functions of these molecules in the underlying pathogenesis of many diseases and to probe the use of the chemokine receptors as targets for therapeutic intervention.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16185672</PMID><DateCreated><Year>2005</Year><Month>12</Month><Day>12</Day></DateCreated><DateCompleted><Year>2006</Year><Month>02</Month><Day>16</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0008-8749</ISSN><JournalIssue CitedMedium="Print"><Volume>236</Volume><Issue>1-2</Issue><PubDate><MedlineDate>2005 Jul-Aug</MedlineDate></PubDate></JournalIssue><Title>Cellular immunology</Title><ISOAbbreviation>Cell. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Cytokine/Chemokine HLDA8 Workshop panel report: analysis of receptors on lymphocytes from cord blood, normal and asthmatic subjects, and HIV positive patients.</ArticleTitle><Pagination><MedlinePgn>105-9</MedlinePgn></Pagination><Abstract><AbstractText>Chemokines and cytokines are involved in many processes, both physiological and pathological, particularly the recruitment, differentiation, activation, and proliferation of immune cells taking part in ontogenesis, inflammation, and cancer. It was assumed that chemokines and cytokines receptors are expressed in a regulated manner by human lymphocytes during ontogeny and later on, under the environmental stimulation of antigens they contribute to organogenesis, angiogenesis, and tissue remodeling, as well as modulating leukocyte effector functions. Using monoclonal antibodies classified by the Cytokine/Chemokine section of the 8th International Workshop on Human Leukocyte Differentiation Antigens, we analyzed human lymphocytes in blood samples drawn from the umbilical cord, normal adults, allergic and non-allergic asthma patients, HIV infected, and AIDS positive subjects. The main differences noted between adult and cord blood lymphocytes were related to CCR7 and CXCR4 receptors, which were more strongly expressed on cord blood lymphocytes, confirming the important role of these chemokines during development of the immune system. As with the HIV, CXCR4, and CCR5 co-receptors, we found no differences in CXCR4 expression between HIV and AIDS patients. However CCR5 was more strongly expressed in AIDS patients, which is likely to be associated with the evolution of disease. Further studies are needed to gain a better understanding of the functions of these molecules in the underlying pathogenesis of many diseases and to probe the use of the chemokine receptors as targets for therapeutic intervention.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Loria</LastName><ForeName>Maria Paola</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Department of Clinical Medicine, Immunology and Infectious Diseases, Section of Allergy and Clinical Immunology, University of Bari, Italy. mp.loria@allergy.uniba.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dambra</LastName><ForeName>Porzia</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Capuzzimati</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Dell'Osso</LastName><ForeName>Adriana</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Crollo</LastName><ForeName>Rossella</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>De Tullio</LastName><ForeName>Giacoma</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Lasaracina</LastName><ForeName>Elena</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Tursi</LastName><ForeName>Alfredo</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2005</Year><Month>09</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell Immunol</MedlineTA><NlmUniqueID>1246405</NlmUniqueID><ISSNLinking>0008-8749</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C515370">CCR7 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019713">Receptors, CCR5</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054400">Receptors, CCR7</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019718">Receptors, CXCR4</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019707">Receptors, Chemokine</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018121">Receptors, Cytokine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000163">Acquired Immunodeficiency Syndrome</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000911">Antibodies, Monoclonal</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001249">Asthma</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005312">Fetal Blood</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015658">HIV Infections</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008214">Lymphocytes</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019713">Receptors, CCR5</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D054400">Receptors, CCR7</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019718">Receptors, CXCR4</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019707">Receptors, Chemokine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018121">Receptors, Cytokine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>2</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2005</Year><Month>6</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2005</Year><Month>9</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>9</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>2</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>9</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0008-8749(05)00161-9</ArticleId><ArticleId IdType="doi">10.1016/j.cellimm.2005.08.015</ArticleId><ArticleId IdType="pubmed">16185672</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix 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