Evidence for the involvement of extinction-associated inhibitory learning in the forced swimming test.
Identifieur interne : 000063 ( PubMed/Corpus ); précédent : 000062; suivant : 000064Evidence for the involvement of extinction-associated inhibitory learning in the forced swimming test.
Auteurs : P. Campus ; V. Colelli ; C. Orsini ; D. Sarra ; S. CabibSource :
- Behavioural brain research [ 1872-7549 ] ; 2015.
English descriptors
- KwdEn :
- Amygdala (drug effects), Amygdala (physiology), Analysis of Variance, Animals, Association Learning (physiology), Extinction, Psychological (drug effects), Extinction, Psychological (physiology), Functional Laterality (drug effects), GABA-A Receptor Agonists (pharmacology), Male, Maze Learning (drug effects), Mice, Mice, Inbred DBA, Muscimol (pharmacology), Neural Inhibition (drug effects), Neural Inhibition (physiology), Reaction Time (drug effects), Swimming (psychology).
- MESH :
- chemical , pharmacology : GABA-A Receptor Agonists, Muscimol.
- drug effects : Amygdala, Extinction, Psychological, Functional Laterality, Maze Learning, Neural Inhibition, Reaction Time.
- physiology : Amygdala, Association Learning, Extinction, Psychological, Neural Inhibition.
- psychology : Swimming.
- Analysis of Variance, Animals, Male, Mice, Mice, Inbred DBA.
Abstract
The forced swimming test (FST) remains one of the most used tools for screening antidepressants in rodent models. Nonetheless, the nature of immobility, its main behavioral measure, is still a matter of debate. The present study took advantage of our recent finding that mice of the inbred DBA/2J strain require a functioning left dorsolateral striatum (DLS) to consolidate long-term memory of FST to test whether immobility is the outcome of stress-related learning. Infusion of the GABA-A agonist muscimol in the left DLS immediately after a single experience of FST prevented and infusion in the left or the right amygdala impaired recall of the acquired levels of immobility in a probe test performed 24h later. Post-training left DLS infusion of muscimol, at a dose capable of preventing retention of FST-induced immobility, did not influence 24h retention of inhibitory avoidance training or of the escape response acquired in a water T-maze. However, this same treatment prevented 24h retention of the extinction training of the consolidated escape response. These results indicate that a left DLS-centered memory system selectively mediates memory consolidation of FST and of escape extinction and support the hypothesis that immobility is the result of extinction-like inhibitory learning involving all available escape responses due to the inescapable/unavoidable nature of FST experience.
DOI: 10.1016/j.bbr.2014.10.009
PubMed: 25448432
Links to Exploration step
pubmed:25448432Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evidence for the involvement of extinction-associated inhibitory learning in the forced swimming test.</title><author><name sortKey="Campus, P" sort="Campus, P" uniqKey="Campus P" first="P" last="Campus">P. Campus</name><affiliation><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Colelli, V" sort="Colelli, V" uniqKey="Colelli V" first="V" last="Colelli">V. Colelli</name><affiliation><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Orsini, C" sort="Orsini, C" uniqKey="Orsini C" first="C" last="Orsini">C. Orsini</name><affiliation><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Sarra, D" sort="Sarra, D" uniqKey="Sarra D" first="D" last="Sarra">D. Sarra</name><affiliation><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cabib, S" sort="Cabib, S" uniqKey="Cabib S" first="S" last="Cabib">S. Cabib</name><affiliation><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy. Electronic address: simona.cabib@uniroma1.it.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25448432</idno><idno type="pmid">25448432</idno><idno type="doi">10.1016/j.bbr.2014.10.009</idno><idno type="wicri:Area/PubMed/Corpus">000063</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000063</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evidence for the involvement of extinction-associated inhibitory learning in the forced swimming test.</title><author><name sortKey="Campus, P" sort="Campus, P" uniqKey="Campus P" first="P" last="Campus">P. Campus</name><affiliation><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Colelli, V" sort="Colelli, V" uniqKey="Colelli V" first="V" last="Colelli">V. Colelli</name><affiliation><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Orsini, C" sort="Orsini, C" uniqKey="Orsini C" first="C" last="Orsini">C. Orsini</name><affiliation><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Sarra, D" sort="Sarra, D" uniqKey="Sarra D" first="D" last="Sarra">D. Sarra</name><affiliation><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cabib, S" sort="Cabib, S" uniqKey="Cabib S" first="S" last="Cabib">S. Cabib</name><affiliation><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy. Electronic address: simona.cabib@uniroma1.it.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Behavioural brain research</title><idno type="eISSN">1872-7549</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amygdala (drug effects)</term><term>Amygdala (physiology)</term><term>Analysis of Variance</term><term>Animals</term><term>Association Learning (physiology)</term><term>Extinction, Psychological (drug effects)</term><term>Extinction, Psychological (physiology)</term><term>Functional Laterality (drug effects)</term><term>GABA-A Receptor Agonists (pharmacology)</term><term>Male</term><term>Maze Learning (drug effects)</term><term>Mice</term><term>Mice, Inbred DBA</term><term>Muscimol (pharmacology)</term><term>Neural Inhibition (drug effects)</term><term>Neural Inhibition (physiology)</term><term>Reaction Time (drug effects)</term><term>Swimming (psychology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>GABA-A Receptor Agonists</term><term>Muscimol</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Amygdala</term><term>Extinction, Psychological</term><term>Functional Laterality</term><term>Maze Learning</term><term>Neural Inhibition</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Amygdala</term><term>Association Learning</term><term>Extinction, Psychological</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Swimming</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Male</term><term>Mice</term><term>Mice, Inbred DBA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The forced swimming test (FST) remains one of the most used tools for screening antidepressants in rodent models. Nonetheless, the nature of immobility, its main behavioral measure, is still a matter of debate. The present study took advantage of our recent finding that mice of the inbred DBA/2J strain require a functioning left dorsolateral striatum (DLS) to consolidate long-term memory of FST to test whether immobility is the outcome of stress-related learning. Infusion of the GABA-A agonist muscimol in the left DLS immediately after a single experience of FST prevented and infusion in the left or the right amygdala impaired recall of the acquired levels of immobility in a probe test performed 24h later. Post-training left DLS infusion of muscimol, at a dose capable of preventing retention of FST-induced immobility, did not influence 24h retention of inhibitory avoidance training or of the escape response acquired in a water T-maze. However, this same treatment prevented 24h retention of the extinction training of the consolidated escape response. These results indicate that a left DLS-centered memory system selectively mediates memory consolidation of FST and of escape extinction and support the hypothesis that immobility is the result of extinction-like inhibitory learning involving all available escape responses due to the inescapable/unavoidable nature of FST experience.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25448432</PMID><DateCreated><Year>2015</Year><Month>03</Month><Day>31</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>15</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7549</ISSN><JournalIssue CitedMedium="Internet"><Volume>278</Volume><PubDate><Year>2015</Year><Month>Feb</Month><Day>1</Day></PubDate></JournalIssue><Title>Behavioural brain research</Title><ISOAbbreviation>Behav. Brain Res.</ISOAbbreviation></Journal><ArticleTitle>Evidence for the involvement of extinction-associated inhibitory learning in the forced swimming test.</ArticleTitle><Pagination><MedlinePgn>348-55</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbr.2014.10.009</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0166-4328(14)00666-4</ELocationID><Abstract><AbstractText>The forced swimming test (FST) remains one of the most used tools for screening antidepressants in rodent models. Nonetheless, the nature of immobility, its main behavioral measure, is still a matter of debate. The present study took advantage of our recent finding that mice of the inbred DBA/2J strain require a functioning left dorsolateral striatum (DLS) to consolidate long-term memory of FST to test whether immobility is the outcome of stress-related learning. Infusion of the GABA-A agonist muscimol in the left DLS immediately after a single experience of FST prevented and infusion in the left or the right amygdala impaired recall of the acquired levels of immobility in a probe test performed 24h later. Post-training left DLS infusion of muscimol, at a dose capable of preventing retention of FST-induced immobility, did not influence 24h retention of inhibitory avoidance training or of the escape response acquired in a water T-maze. However, this same treatment prevented 24h retention of the extinction training of the consolidated escape response. These results indicate that a left DLS-centered memory system selectively mediates memory consolidation of FST and of escape extinction and support the hypothesis that immobility is the result of extinction-like inhibitory learning involving all available escape responses due to the inescapable/unavoidable nature of FST experience.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Campus</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colelli</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Orsini</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sarra</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cabib</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy. Electronic address: simona.cabib@uniroma1.it.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>10</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Behav Brain Res</MedlineTA><NlmUniqueID>8004872</NlmUniqueID><ISSNLinking>0166-4328</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D058785">GABA-A Receptor Agonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>2763-96-4</RegistryNumber><NameOfSubstance UI="D009118">Muscimol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000679">Amygdala</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000704">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001245">Association Learning</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005108">Extinction, Psychological</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007839">Functional Laterality</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D058785">GABA-A Receptor Agonists</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018782">Maze Learning</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051379">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008811">Mice, Inbred DBA</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009118">Muscimol</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009433">Neural Inhibition</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013550">Swimming</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000523">psychology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Animal model</Keyword><Keyword MajorTopicYN="N">Coping</Keyword><Keyword MajorTopicYN="N">Depression</Keyword><Keyword MajorTopicYN="N">Extinction</Keyword><Keyword MajorTopicYN="N">Memory consolidation</Keyword><Keyword MajorTopicYN="N">Stress</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>8</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>10</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>10</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>10</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25448432</ArticleId><ArticleId IdType="pii">S0166-4328(14)00666-4</ArticleId><ArticleId IdType="doi">10.1016/j.bbr.2014.10.009</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/InforLorV4/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000063 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000063 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Lorraine
|area= InforLorV4
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:25448432
|texte= Evidence for the involvement of extinction-associated inhibitory learning in the forced swimming test.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:25448432" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a InforLorV4
| This area was generated with Dilib version V0.6.33. |  |