InforLorV4, PascalFrancis, Corpus, bibRecord, 000623

A multi-scale constraint programming model of alternative splicing regulation

Identifieur interne : 000623 ( PascalFrancis/Corpus ); précédent : 000622; suivant : 000624

A multi-scale constraint programming model of alternative splicing regulation

Auteurs : Damien Eveillard ; Delphine Ropers ; Hidde De Jong ; Christiane Branlant ; Alexander Bockmayr

Source :

Theoretical computer science [ 0304-3975 ] ; 2004.

RBID : Pascal:04-0532825

Descripteurs français

Pascal (Inist)
- Programmation logique avec contrainte, Biologie mathématique, Epissage alternatif, Modélisation, Système hybride, Virus immunodéficience humaine, Virus HIV1, Donnée expérimentale, RNA, Informatique théorique, Régulation épissage, Complexité combinatoire.

English descriptors

KwdEn :
- Alternative splicing, Combinatorial complexity, Computer theory, Constraint logic programming, Experimental data, HIV-1 virus, Human immunodeficiency virus, Hybrid system, Mathematical biology, Modeling, RNA, Splicing regulation.

Abstract

Alternative splicing is a key process in post-transcriptional regulation, by which different mature RNA can be obtained from the same premessenger RNA. The resulting combinatorial complexity contributes to biological diversity, especially in the case of the human immunodeficiency virus HIV-1. Using a constraint programming approach, we develop a model of the alternative splicing regulation in HIV-1. Our model integrates different scales (single site vs. multiple sites), and thus allows us to exploit several types of experimental data available to us.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`02`	`1`		`@1 ROPERS (Delphine)`
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A11	`04`	`1`		`@1 BRANLANT (Christiane)`
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A14	`03`			`@1 INRIA Rhône-Alpes, Helix Project, 655 avenue de l'Europe, Montbonnot @2 38334 Saint Ismier @3 FRA @Z 3 aut.`
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C01	`01`		`ENG`	@0 Alternative splicing is a key process in post-transcriptional regulation, by which different mature RNA can be obtained from the same premessenger RNA. The resulting combinatorial complexity contributes to biological diversity, especially in the case of the human immunodeficiency virus HIV-1. Using a constraint programming approach, we develop a model of the alternative splicing regulation in HIV-1. Our model integrates different scales (single site vs. multiple sites), and thus allows us to exploit several types of experimental data available to us.
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C03	`08`	`X`	`FRE`	`@0 Donnée expérimentale @5 24`
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C03	`09`	`X`	`FRE`	`@0 RNA @5 26`
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C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
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A30	`01`	`1`	`ENG`	`@1 International Workshop on Computational Methods in Systems Biology @3 Rovereto ITA @4 2003-02-24`

Format Inist (serveur)

NO :	PASCAL 04-0532825 INIST
ET :	A multi-scale constraint programming model of alternative splicing regulation
AU :	EVEILLARD (Damien); ROPERS (Delphine); DE JONG (Hidde); BRANLANT (Christiane); BOCKMAYR (Alexander); PRIAMI (Corrado)
AF :	LORIA, Université Henri Poincaré, BP 239/54506 Vandoeuvre-lès-Nancy/France (1 aut., 5 aut.); Laboratoire de Maturation des ARN et Enzymologie Moléculaire, UMR 7567 CNRS-UHP, BP 239/54506 Vandoeuvre-lès-Nancy/France (1 aut., 2 aut., 4 aut.); INRIA Rhône-Alpes, Helix Project, 655 avenue de l'Europe, Montbonnot/38334 Saint Ismier/France (3 aut.); Dipartimento di Informatica e Telecommunicazioni, Universita' di Trento, Via Sommarive, 14/Povo (TN) 38050/Italie (1 aut.)
DT :	Publication en série; Congrès; Niveau analytique
SO :	Theoretical computer science; ISSN 0304-3975; Coden TCSCDI; Pays-Bas; Da. 2004; Vol. 325; No. 1; Pp. 3-24; Bibl. 25 ref.
LA :	Anglais
EA :	Alternative splicing is a key process in post-transcriptional regulation, by which different mature RNA can be obtained from the same premessenger RNA. The resulting combinatorial complexity contributes to biological diversity, especially in the case of the human immunodeficiency virus HIV-1. Using a constraint programming approach, we develop a model of the alternative splicing regulation in HIV-1. Our model integrates different scales (single site vs. multiple sites), and thus allows us to exploit several types of experimental data available to us.
CC :	001D02A05; 001A02E18; 002A01B; 001D02A03
FD :	Programmation logique avec contrainte; Biologie mathématique; Epissage alternatif; Modélisation; Système hybride; Virus immunodéficience humaine; Virus HIV1; Donnée expérimentale; RNA; Informatique théorique; Régulation épissage; Complexité combinatoire
FG :	Lentivirus; Retroviridae; Virus
ED :	Constraint logic programming; Mathematical biology; Alternative splicing; Modeling; Hybrid system; Human immunodeficiency virus; HIV-1 virus; Experimental data; RNA; Computer theory; Splicing regulation; Combinatorial complexity
EG :	Lentivirus; Retroviridae; Virus
SD :	Programación lógica con restricción; Biología matemática; Empalme alternativo; Modelización; Sistema híbrido; Human immunodeficiency virus; HIV-1 virus; Dato experimental; RNA; Informática teórica
LO :	INIST-17243.354000120342200010
ID :	04-0532825

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Pascal:04-0532825

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</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Biología matemática</s0>
<s5>18</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Epissage alternatif</s0>
<s5>19</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Alternative splicing</s0>
<s5>19</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Empalme alternativo</s0>
<s5>19</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Modélisation</s0>
<s5>20</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Modeling</s0>
<s5>20</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Modelización</s0>
<s5>20</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Système hybride</s0>
<s5>21</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Hybrid system</s0>
<s5>21</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Sistema híbrido</s0>
<s5>21</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Virus immunodéficience humaine</s0>
<s2>NW</s2>
<s5>22</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Human immunodeficiency virus</s0>
<s2>NW</s2>
<s5>22</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Human immunodeficiency virus</s0>
<s2>NW</s2>
<s5>22</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Virus HIV1</s0>
<s2>NW</s2>
<s5>23</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>HIV-1 virus</s0>
<s2>NW</s2>
<s5>23</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>HIV-1 virus</s0>
<s2>NW</s2>
<s5>23</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Donnée expérimentale</s0>
<s5>24</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Experimental data</s0>
<s5>24</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Dato experimental</s0>
<s5>24</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>RNA</s0>
<s5>26</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>RNA</s0>
<s5>26</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>RNA</s0>
<s5>26</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Informatique théorique</s0>
<s5>27</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Computer theory</s0>
<s5>27</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Informática teórica</s0>
<s5>27</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Régulation épissage</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Splicing regulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Complexité combinatoire</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Combinatorial complexity</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Lentivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Lentivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Lentivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Retroviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Retroviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Retroviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fN21><s1>299</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
<pR><fA30 i1="01" i2="1" l="ENG"><s1>International Workshop on Computational Methods in Systems Biology</s1>
<s3>Rovereto ITA</s3>
<s4>2003-02-24</s4>
</fA30>
</pR>
</standard>
<server><NO>PASCAL 04-0532825 INIST</NO>
<ET>A multi-scale constraint programming model of alternative splicing regulation</ET>
<AU>EVEILLARD (Damien); ROPERS (Delphine); DE JONG (Hidde); BRANLANT (Christiane); BOCKMAYR (Alexander); PRIAMI (Corrado)</AU>
<AF>LORIA, Université Henri Poincaré, BP 239/54506 Vandoeuvre-lès-Nancy/France (1 aut., 5 aut.); Laboratoire de Maturation des ARN et Enzymologie Moléculaire, UMR 7567 CNRS-UHP, BP 239/54506 Vandoeuvre-lès-Nancy/France (1 aut., 2 aut., 4 aut.); INRIA Rhône-Alpes, Helix Project, 655 avenue de l'Europe, Montbonnot/38334 Saint Ismier/France (3 aut.); Dipartimento di Informatica e Telecommunicazioni, Universita' di Trento, Via Sommarive, 14/Povo (TN) 38050/Italie (1 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Theoretical computer science; ISSN 0304-3975; Coden TCSCDI; Pays-Bas; Da. 2004; Vol. 325; No. 1; Pp. 3-24; Bibl. 25 ref.</SO>
<LA>Anglais</LA>
<EA>Alternative splicing is a key process in post-transcriptional regulation, by which different mature RNA can be obtained from the same premessenger RNA. The resulting combinatorial complexity contributes to biological diversity, especially in the case of the human immunodeficiency virus HIV-1. Using a constraint programming approach, we develop a model of the alternative splicing regulation in HIV-1. Our model integrates different scales (single site vs. multiple sites), and thus allows us to exploit several types of experimental data available to us.</EA>
<CC>001D02A05; 001A02E18; 002A01B; 001D02A03</CC>
<FD>Programmation logique avec contrainte; Biologie mathématique; Epissage alternatif; Modélisation; Système hybride; Virus immunodéficience humaine; Virus HIV1; Donnée expérimentale; RNA; Informatique théorique; Régulation épissage; Complexité combinatoire</FD>
<FG>Lentivirus; Retroviridae; Virus</FG>
<ED>Constraint logic programming; Mathematical biology; Alternative splicing; Modeling; Hybrid system; Human immunodeficiency virus; HIV-1 virus; Experimental data; RNA; Computer theory; Splicing regulation; Combinatorial complexity</ED>
<EG>Lentivirus; Retroviridae; Virus</EG>
<SD>Programación lógica con restricción; Biología matemática; Empalme alternativo; Modelización; Sistema híbrido; Human immunodeficiency virus; HIV-1 virus; Dato experimental; RNA; Informática teórica</SD>
<LO>INIST-17243.354000120342200010</LO>
<ID>04-0532825</ID>
</server>
</inist>
</record>

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A multi-scale constraint programming model of alternative splicing regulation

A multi-scale constraint programming model of alternative splicing regulation

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