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Beta Androstenediol Mitigates the Damage of 1 GeV/n Fe Ion Particle Radiation to the Hematopoietic System

Identifieur interne : 000116 ( Ncbi/Curation ); précédent : 000115; suivant : 000117

Beta Androstenediol Mitigates the Damage of 1 GeV/n Fe Ion Particle Radiation to the Hematopoietic System

Auteurs : Roger Loria ; Mathew Beckman ; Daniel Contaifer ; Francisco Tamariz ; David Gibb ; Laura Thompson ; Peter Guida

Source :

Cancer Biotherapy & Radiopharmaceuticals [ 1084-9785 ] ; 2011.

RBID : PMC:3192055

Descripteurs français

KwdFr :
- Androstènediol (pharmacologie), Animaux, Cellules de la moelle osseuse (), Cellules de la moelle osseuse (effets des radiations), Cytométrie en flux, Fer (), Injections sous-cutanées, Ions lourds (effets indésirables), Irradiation corporelle totale, Lésions expérimentales radio-induites (), Lésions expérimentales radio-induites (étiologie), Moelle osseuse (), Moelle osseuse (effets des radiations), Mâle, Ostéoclastes (), Ostéoclastes (cytologie), Ostéoclastes (effets des radiations), Radioprotecteurs (pharmacologie), Souris, Souris de lignée C57BL, Système hématopoïétique (), Système hématopoïétique (effets des radiations).
MESH :
- cytologie : Ostéoclastes.
- effets des radiations : Cellules de la moelle osseuse, Moelle osseuse, Ostéoclastes, Système hématopoïétique.
- effets indésirables : Ions lourds.
- pharmacologie : Androstènediol, Radioprotecteurs.
- étiologie : Lésions expérimentales radio-induites.
- Animaux, Cellules de la moelle osseuse, Cytométrie en flux, Fer, Injections sous-cutanées, Irradiation corporelle totale, Lésions expérimentales radio-induites, Moelle osseuse, Mâle, Ostéoclastes, Souris, Souris de lignée C57BL, Système hématopoïétique.

English descriptors

KwdEn :
- Androstenediol (pharmacology), Animals, Bone Marrow (drug effects), Bone Marrow (radiation effects), Bone Marrow Cells (drug effects), Bone Marrow Cells (radiation effects), Flow Cytometry, Heavy Ions (adverse effects), Hematopoietic System (drug effects), Hematopoietic System (radiation effects), Injections, Subcutaneous, Iron (chemistry), Male, Mice, Mice, Inbred C57BL, Osteoclasts (cytology), Osteoclasts (drug effects), Osteoclasts (radiation effects), Radiation Injuries, Experimental (etiology), Radiation Injuries, Experimental (prevention & control), Radiation-Protective Agents (pharmacology), Whole-Body Irradiation.
MESH :
- chemical , chemistry : Iron.
- chemical , pharmacology : Androstenediol, Radiation-Protective Agents.
- adverse effects : Heavy Ions.
- cytology : Osteoclasts.
- drug effects : Bone Marrow, Bone Marrow Cells, Hematopoietic System, Osteoclasts.
- etiology : Radiation Injuries, Experimental.
- prevention & control : Radiation Injuries, Experimental.
- radiation effects : Bone Marrow, Bone Marrow Cells, Hematopoietic System, Osteoclasts.
- Animals, Flow Cytometry, Injections, Subcutaneous, Male, Mice, Mice, Inbred C57BL, Whole-Body Irradiation.

Abstract

Space exploration is associated with exposure to 1–3 Gy solar particle radiation and galactic cosmic radiation that could increase cancer rates. Effective nontoxic countermeasures to high linear energy transfer (LET) radiation exposure are highly desirable but currently not available. The aim was to determine whether a single subcutaneous injection of androstenediol (Δ⁵ androsten-3β, 17β-diol [AED]) could mitigate and restore the mouse hematopoetic system from the radiation-mediated injury of 3 Gy whole-body high LET ⁵⁶Fe²⁶⁺ exposure. The findings show that postradiation AED treatment has an overall positive and significant beneficial effect to restore the levels of hematopoeitic elements (p<0.001). Androstenediol treatment significantly increased monocyte levels at days 4, 7, and 14 and, similarly, increased red blood cell, hemoglobin, and platelet counts. Flow cytometry analysis 14 days after radiation and AED treatment demonstrated an increase (p<0.05) in bone marrow cells counts. Ex vivo osteoclastogenesis studies show that AED treatment is necessary and advantageous for the development and restoration of osteoclastogenesis after radiation exposure. These findings clearly show that androstenediol functions as a countermeasure to remedy hematopoeitic injury mediated by high LET iron ion radiation. Presently, no other agent has been shown to have such properties.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192055

DOI: 10.1089/cbr.2010.0907
PubMed: 21790310
PubMed Central: 3192055

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PMC:3192055

Le document en format XML

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<term>Injections sous-cutanées</term>
<term>Irradiation corporelle totale</term>
<term>Lésions expérimentales radio-induites</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Space exploration is associated with exposure to 1–3 Gy solar particle radiation and galactic cosmic radiation that could increase cancer rates. Effective nontoxic countermeasures to high linear energy transfer (LET) radiation exposure are highly desirable but currently not available. The aim was to determine whether a single subcutaneous injection of androstenediol (Δ<sup>5</sup>
 androsten-3β, 17β-diol [AED]) could mitigate and restore the mouse hematopoetic system from the radiation-mediated injury of 3 Gy whole-body high LET <sup>56</sup>
Fe<sup>26+</sup>
 exposure. The findings show that postradiation AED treatment has an overall positive and significant beneficial effect to restore the levels of hematopoeitic elements (<italic>p</italic>
<0.001). Androstenediol treatment significantly increased monocyte levels at days 4, 7, and 14 and, similarly, increased red blood cell, hemoglobin, and platelet counts. Flow cytometry analysis 14 days after radiation and AED treatment demonstrated an increase (<italic>p</italic>
<0.05) in bone marrow cells counts. <italic>Ex vivo</italic>
 osteoclastogenesis studies show that AED treatment is necessary and advantageous for the development and restoration of osteoclastogenesis after radiation exposure. These findings clearly show that androstenediol functions as a countermeasure to remedy hematopoeitic injury mediated by high LET iron ion radiation. Presently, no other agent has been shown to have such properties.</p>
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</front>
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Beta Androstenediol Mitigates the Damage of 1 GeV/n Fe Ion Particle Radiation to the Hematopoietic System

Beta Androstenediol Mitigates the Damage of 1 GeV/n Fe Ion Particle Radiation to the Hematopoietic System

Source :

Descripteurs français

English descriptors

Abstract

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