The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries.
Identifieur interne : 000740 ( Main/Exploration ); précédent : 000739; suivant : 000741The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries.
Auteurs : Laurent Calvier [France] ; Ernesto Martinez-Martinez [Espagne] ; Maria Miana [Espagne] ; Victoria Cachofeiro [Espagne] ; Elodie Rousseau [France] ; J Rafael Sádaba [Espagne] ; Faiez Zannad [France] ; Patrick Rossignol [France] ; Natalia L Pez-Andrés [Espagne]Source :
- JACC. Heart failure [ 2213-1787 ] ; 2015.
Descripteurs français
- KwdFr :
- Aldostérone (toxicité), Animaux, Antagonistes des récepteurs des minéralocorticoïdes (usage thérapeutique), Atteinte rénale aigüe (), Atteinte rénale aigüe (métabolisme), Atteinte rénale aigüe (traitement médicamenteux), Défaillance cardiaque (), Défaillance cardiaque (métabolisme), Défaillance cardiaque (traitement médicamenteux), Galectine -3 (antagonistes et inhibiteurs), Galectine -3 (biosynthèse), Immunohistochimie, Modèles animaux de maladie humaine, Mâle, Rat Wistar, Rats, Souris, Souris de lignée C57BL, Souris knockout, Spironolactone (usage thérapeutique), Test ELISA.
- MESH :
- antagonistes et inhibiteurs : Galectine -3.
- biosynthèse : Galectine -3.
- métabolisme : Atteinte rénale aigüe, Défaillance cardiaque.
- toxicité : Aldostérone.
- traitement médicamenteux : Atteinte rénale aigüe, Défaillance cardiaque.
- usage thérapeutique : Antagonistes des récepteurs des minéralocorticoïdes, Spironolactone.
- Animaux, Atteinte rénale aigüe, Défaillance cardiaque, Immunohistochimie, Modèles animaux de maladie humaine, Mâle, Rat Wistar, Rats, Souris, Souris de lignée C57BL, Souris knockout, Test ELISA.
English descriptors
- KwdEn :
- Acute Kidney Injury (chemically induced), Acute Kidney Injury (drug therapy), Acute Kidney Injury (metabolism), Aldosterone (toxicity), Animals, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Galectin 3 (antagonists & inhibitors), Galectin 3 (biosynthesis), Heart Failure (chemically induced), Heart Failure (drug therapy), Heart Failure (metabolism), Immunohistochemistry, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mineralocorticoid Receptor Antagonists (therapeutic use), Rats, Rats, Wistar, Spironolactone (therapeutic use).
- MESH :
- chemical , antagonists & inhibitors : Galectin 3.
- chemical , biosynthesis : Galectin 3.
- chemical , therapeutic use : Mineralocorticoid Receptor Antagonists, Spironolactone.
- chemical , toxicity : Aldosterone.
- chemically induced : Acute Kidney Injury, Heart Failure.
- drug therapy : Acute Kidney Injury, Heart Failure.
- metabolism : Acute Kidney Injury, Heart Failure.
- Animals, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Immunohistochemistry, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Rats, Rats, Wistar.
Abstract
This study investigated whether galectin (Gal)-3 inhibition could block aldosterone-induced cardiac and renal fibrosis and improve cardiorenal dysfunction.
DOI: 10.1016/j.jchf.2014.08.002
PubMed: 25458174
Affiliations:
- Espagne, France
- Communauté de Madrid, Grand Est, Lorraine (région)
- Madrid, Nancy, Vandœuvre-lès-Nancy
- Université complutense de Madrid
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000062
- to stream PubMed, to step Curation: 000062
- to stream PubMed, to step Checkpoint: 000030
- to stream Ncbi, to step Merge: 000179
- to stream Ncbi, to step Curation: 000173
- to stream Ncbi, to step Checkpoint: 000173
- to stream Main, to step Merge: 000729
- to stream Main, to step Curation: 000740
Le document en format XML
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Navarrabiomed-Fundación Miguel Servet, Pamplona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universidad Complutense de Madrid, Madrid, Spain; Navarrabiomed-Fundación Miguel Servet, Pamplona</wicri:regionArea><orgName type="university">Université complutense de Madrid</orgName><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Miana, Maria" sort="Miana, Maria" uniqKey="Miana M" first="Maria" last="Miana">Maria Miana</name><affiliation wicri:level="4"><nlm:affiliation>Universidad Complutense de Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universidad Complutense de Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName><orgName type="university">Université complutense de Madrid</orgName></affiliation></author><author><name sortKey="Cachofeiro, Victoria" sort="Cachofeiro, Victoria" uniqKey="Cachofeiro V" first="Victoria" last="Cachofeiro">Victoria Cachofeiro</name><affiliation wicri:level="4"><nlm:affiliation>Universidad Complutense de Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universidad Complutense de Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName><orgName type="university">Université complutense de Madrid</orgName></affiliation></author><author><name sortKey="Rousseau, Elodie" sort="Rousseau, Elodie" uniqKey="Rousseau E" first="Elodie" last="Rousseau">Elodie Rousseau</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Université de Lorraine UMR 1116, Vandoeuvre-Lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Université de Lorraine UMR 1116, Vandoeuvre-Lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Sadaba, J Rafael" sort="Sadaba, J Rafael" uniqKey="Sadaba J" first="J Rafael" last="Sádaba">J Rafael Sádaba</name><affiliation wicri:level="1"><nlm:affiliation>Navarrabiomed-Fundación Miguel Servet, Pamplona, Spain; 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Navarrabiomed-Fundación Miguel Servet, Pamplona, Spain. Electronic address: natalia.lopez.andres@navarra.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>INSERM, Université de Lorraine UMR 1116, Vandoeuvre-Lès-Nancy, France; Navarrabiomed-Fundación Miguel Servet, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author></analytic><series><title level="j">JACC. Heart failure</title><idno type="eISSN">2213-1787</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Kidney Injury (chemically induced)</term><term>Acute Kidney Injury (drug therapy)</term><term>Acute Kidney Injury (metabolism)</term><term>Aldosterone (toxicity)</term><term>Animals</term><term>Disease Models, Animal</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Galectin 3 (antagonists & inhibitors)</term><term>Galectin 3 (biosynthesis)</term><term>Heart Failure (chemically induced)</term><term>Heart Failure (drug therapy)</term><term>Heart Failure (metabolism)</term><term>Immunohistochemistry</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Mineralocorticoid Receptor Antagonists (therapeutic use)</term><term>Rats</term><term>Rats, Wistar</term><term>Spironolactone (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aldostérone (toxicité)</term><term>Animaux</term><term>Antagonistes des récepteurs des minéralocorticoïdes (usage thérapeutique)</term><term>Atteinte rénale aigüe ()</term><term>Atteinte rénale aigüe (métabolisme)</term><term>Atteinte rénale aigüe (traitement médicamenteux)</term><term>Défaillance cardiaque ()</term><term>Défaillance cardiaque (métabolisme)</term><term>Défaillance cardiaque (traitement médicamenteux)</term><term>Galectine -3 (antagonistes et inhibiteurs)</term><term>Galectine -3 (biosynthèse)</term><term>Immunohistochimie</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Rat Wistar</term><term>Rats</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Spironolactone (usage thérapeutique)</term><term>Test ELISA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Galectin 3</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Galectin 3</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Mineralocorticoid Receptor Antagonists</term><term>Spironolactone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Aldosterone</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Galectine -3</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Galectine -3</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Acute Kidney Injury</term><term>Heart Failure</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Acute Kidney Injury</term><term>Heart Failure</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Acute Kidney Injury</term><term>Heart Failure</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Atteinte rénale aigüe</term><term>Défaillance cardiaque</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Aldostérone</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Atteinte rénale aigüe</term><term>Défaillance cardiaque</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antagonistes des récepteurs des minéralocorticoïdes</term><term>Spironolactone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Immunohistochemistry</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Atteinte rénale aigüe</term><term>Défaillance cardiaque</term><term>Immunohistochimie</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Rat Wistar</term><term>Rats</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study investigated whether galectin (Gal)-3 inhibition could block aldosterone-induced cardiac and renal fibrosis and improve cardiorenal dysfunction.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>France</li></country><region><li>Communauté de Madrid</li><li>Grand Est</li><li>Lorraine (région)</li></region><settlement><li>Madrid</li><li>Nancy</li><li>Vandœuvre-lès-Nancy</li></settlement><orgName><li>Université complutense de Madrid</li></orgName></list><tree><country name="France"><region name="Grand Est"><name sortKey="Calvier, Laurent" sort="Calvier, Laurent" uniqKey="Calvier L" first="Laurent" last="Calvier">Laurent Calvier</name></region><name sortKey="Rossignol, Patrick" sort="Rossignol, Patrick" uniqKey="Rossignol P" first="Patrick" last="Rossignol">Patrick Rossignol</name><name sortKey="Rousseau, Elodie" sort="Rousseau, Elodie" uniqKey="Rousseau E" first="Elodie" last="Rousseau">Elodie Rousseau</name><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martinez Martinez, Ernesto" sort="Martinez Martinez, Ernesto" uniqKey="Martinez Martinez E" first="Ernesto" last="Martinez-Martinez">Ernesto Martinez-Martinez</name></region><name sortKey="Cachofeiro, Victoria" sort="Cachofeiro, Victoria" uniqKey="Cachofeiro V" first="Victoria" last="Cachofeiro">Victoria Cachofeiro</name><name sortKey="L Pez Andres, Natalia" sort="L Pez Andres, Natalia" uniqKey="L Pez Andres N" first="Natalia" last="L Pez-Andrés">Natalia L Pez-Andrés</name><name sortKey="Miana, Maria" sort="Miana, Maria" uniqKey="Miana M" first="Maria" last="Miana">Maria Miana</name><name sortKey="Sadaba, J Rafael" sort="Sadaba, J Rafael" uniqKey="Sadaba J" first="J Rafael" last="Sádaba">J Rafael Sádaba</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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