Clinicopathologic correlates of prednisone treatment of human immunodeficiency virus-associated nephropathy
Identifieur interne : 00BF65 ( Main/Exploration ); précédent : 00BF64; suivant : 00BF66Clinicopathologic correlates of prednisone treatment of human immunodeficiency virus-associated nephropathy
Auteurs : William A. Briggs [États-Unis] ; Somsak Tanawattanacharoen [États-Unis] ; Michael J. Choi [États-Unis] ; Paul J. Scheel Jr [États-Unis] ; Tibor Nadasdy [États-Unis] ; Lorraine Racusen [États-Unis]Source :
- American Journal of Kidney Diseases [ 0272-6386 ] ; 1996.
English descriptors
- Teeft :
- Beneficial effect, Biopsy, Case report, Clinical features, Creatinine, Defic syndr, Esrd, First report, Glucocorticoid, Histopathology, Hivan, Human immunodeficiency virus, Human immunodeficiency virus infection, Immunodeficiency, Lymphocyte, Microangiopathic, Microangiopathy, National kidney foundation, Nephropathy, Original magnification, Posttreatment, Prednisone, Prednisone dosage, Pretreatment, Pretreatment biopsy, Renal, Renal biopsies, Renal disease, Renal function, Serum creatinine, Sputum cultures, Steroid, Steroid therapy, Therapeutic intervention, Thrombotic, Thrombotic microangiopathic changes, Thrombotic microangiopathy, Zidovudine.
Abstract
Abstract: A 43-YEAR-OLD MAN with rapidly evolving renal failure from biopsy-proven human immunodeficiency virus (HIV)-associated nephropathy (HIVAN) and superimposed thrombotic microangiopathic changes was treated with prednisone. His serum creatinine decreased from 7.5 to 3.9 mg/dL, and the 24-hour protein excretion decreased from 15.7 to 6.1 g over 6 to 8 weeks. As the prednisone was tapered, however, the creatinine began to increase, and a repeat biopsy was done to assist with therapeutic decisions. The major differences from the pretreatment biopsy were marked reductions in interstitial lymphocytes and macrophages and absence of thrombotic microangiopathic lesions. This is the first report comparing pretreatment and posttreatment renal biopsy specimens and the findings provide some insight into the means by which prednisone exerts its beneficial clinical effects acutely on this disease.
Url:
DOI: 10.1016/S0272-6386(96)90477-1
Affiliations:
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His serum creatinine decreased from 7.5 to 3.9 mg/dL, and the 24-hour protein excretion decreased from 15.7 to 6.1 g over 6 to 8 weeks. As the prednisone was tapered, however, the creatinine began to increase, and a repeat biopsy was done to assist with therapeutic decisions. The major differences from the pretreatment biopsy were marked reductions in interstitial lymphocytes and macrophages and absence of thrombotic microangiopathic lesions. This is the first report comparing pretreatment and posttreatment renal biopsy specimens and the findings provide some insight into the means by which prednisone exerts its beneficial clinical effects acutely on this disease.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Briggs, William A" sort="Briggs, William A" uniqKey="Briggs W" first="William A." last="Briggs">William A. 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