Physiological role and clinical utility of inositols in polycystic ovary syndrome.
Identifieur interne : 000143 ( Main/Exploration ); précédent : 000142; suivant : 000144Physiological role and clinical utility of inositols in polycystic ovary syndrome.
Auteurs : Arturo Bevilacqua [Italie] ; Mariano Bizzarri [Italie]Source :
- Best practice & research. Clinical obstetrics & gynaecology [ 1532-1932 ] ; 2016.
Abstract
During the last decades, a substantial body of research has focused on the role of the two major inositol (Ins) stereoisomers, myoinositol (myoIns) and D-chiroinositol (D-chiroIns), both second messengers of insulin, in insulin-dependent processes, including polycystic ovary syndrome (PCOS). MyoIns has been shown to affect different pathways at both ovarian and non-ovarian level. On the contrary, D-chiroIns alone is unable to exert significant improvements in the ovarian cell functions, as its beneficial effects are mainly limited to the non-ovarian tissue in which it may significantly inhibit the negative cellular consequences of hyperinsulinemia. However, both Ins isomers can be positively associated in the management of PCOS patients in a ratio corresponding to their physiological plasma ratio (40:1). This appears to exert a synergistic effect according to a multi-targeted design. In this respect, new fundamental insights into the biological mechanisms displayed by Ins, as well as clinical trials based on the myoIns + D-chiroIns formulations, have already provided encouraging results.
DOI: 10.1016/j.bpobgyn.2016.03.007
PubMed: 27117028
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000003
- to stream PubMed, to step Curation: 000003
- to stream PubMed, to step Checkpoint: 000010
- to stream Ncbi, to step Merge: 000241
- to stream Ncbi, to step Curation: 000232
- to stream Ncbi, to step Checkpoint: 000232
- to stream Main, to step Merge: 000129
- to stream Main, to step Curation: 000143
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Physiological role and clinical utility of inositols in polycystic ovary syndrome.</title><author><name sortKey="Bevilacqua, Arturo" sort="Bevilacqua, Arturo" uniqKey="Bevilacqua A" first="Arturo" last="Bevilacqua">Arturo Bevilacqua</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Section of Neuroscience, Sapienza University of Rome, via dei Marsi 78, 00185 Rome, Italy; "Research Center in Neurobiology Daniel Bovet" (CRiN), 00185 Rome, Italy. Electronic address: arturo.bevilacqua@uniroma1.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Psychology, Section of Neuroscience, Sapienza University of Rome, via dei Marsi 78, 00185 Rome, Italy; "Research Center in Neurobiology Daniel Bovet" (CRiN), 00185 Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bizzarri, Mariano" sort="Bizzarri, Mariano" uniqKey="Bizzarri M" first="Mariano" last="Bizzarri">Mariano Bizzarri</name><affiliation wicri:level="3"><nlm:affiliation>Department of Experimental Medicine, Sapienza University of Rome, viale Regina Elena 324, 00161 Rome, Italy; Systems Biology Group Lab, Sapienza University of Rome, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental Medicine, Sapienza University of Rome, viale Regina Elena 324, 00161 Rome, Italy; Systems Biology Group Lab, Sapienza University of Rome, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="doi">10.1016/j.bpobgyn.2016.03.007</idno><idno type="RBID">pubmed:27117028</idno><idno type="pmid">27117028</idno><idno type="wicri:Area/PubMed/Corpus">000003</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000003</idno><idno type="wicri:Area/PubMed/Curation">000003</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000003</idno><idno type="wicri:Area/PubMed/Checkpoint">000010</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000010</idno><idno type="wicri:Area/Ncbi/Merge">000241</idno><idno type="wicri:Area/Ncbi/Curation">000232</idno><idno type="wicri:Area/Ncbi/Checkpoint">000232</idno><idno type="wicri:Area/Main/Merge">000129</idno><idno type="wicri:Area/Main/Curation">000143</idno><idno type="wicri:Area/Main/Exploration">000143</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Physiological role and clinical utility of inositols in polycystic ovary syndrome.</title><author><name sortKey="Bevilacqua, Arturo" sort="Bevilacqua, Arturo" uniqKey="Bevilacqua A" first="Arturo" last="Bevilacqua">Arturo Bevilacqua</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Section of Neuroscience, Sapienza University of Rome, via dei Marsi 78, 00185 Rome, Italy; "Research Center in Neurobiology Daniel Bovet" (CRiN), 00185 Rome, Italy. Electronic address: arturo.bevilacqua@uniroma1.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Psychology, Section of Neuroscience, Sapienza University of Rome, via dei Marsi 78, 00185 Rome, Italy; "Research Center in Neurobiology Daniel Bovet" (CRiN), 00185 Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bizzarri, Mariano" sort="Bizzarri, Mariano" uniqKey="Bizzarri M" first="Mariano" last="Bizzarri">Mariano Bizzarri</name><affiliation wicri:level="3"><nlm:affiliation>Department of Experimental Medicine, Sapienza University of Rome, viale Regina Elena 324, 00161 Rome, Italy; Systems Biology Group Lab, Sapienza University of Rome, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental Medicine, Sapienza University of Rome, viale Regina Elena 324, 00161 Rome, Italy; Systems Biology Group Lab, Sapienza University of Rome, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><series><title level="j">Best practice & research. Clinical obstetrics & gynaecology</title><idno type="eISSN">1532-1932</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the last decades, a substantial body of research has focused on the role of the two major inositol (Ins) stereoisomers, myoinositol (myoIns) and D-chiroinositol (D-chiroIns), both second messengers of insulin, in insulin-dependent processes, including polycystic ovary syndrome (PCOS). MyoIns has been shown to affect different pathways at both ovarian and non-ovarian level. On the contrary, D-chiroIns alone is unable to exert significant improvements in the ovarian cell functions, as its beneficial effects are mainly limited to the non-ovarian tissue in which it may significantly inhibit the negative cellular consequences of hyperinsulinemia. However, both Ins isomers can be positively associated in the management of PCOS patients in a ratio corresponding to their physiological plasma ratio (40:1). This appears to exert a synergistic effect according to a multi-targeted design. In this respect, new fundamental insights into the biological mechanisms displayed by Ins, as well as clinical trials based on the myoIns + D-chiroIns formulations, have already provided encouraging results.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Bevilacqua, Arturo" sort="Bevilacqua, Arturo" uniqKey="Bevilacqua A" first="Arturo" last="Bevilacqua">Arturo Bevilacqua</name></region><name sortKey="Bizzarri, Mariano" sort="Bizzarri, Mariano" uniqKey="Bizzarri M" first="Mariano" last="Bizzarri">Mariano Bizzarri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/InforLorV4/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000143 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000143 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Lorraine
|area= InforLorV4
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27117028
|texte= Physiological role and clinical utility of inositols in polycystic ovary syndrome.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27117028" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a InforLorV4
| This area was generated with Dilib version V0.6.33. |  |