Is the psychological impact of genetic testing moderated by support and sharing of test results to family and friends?
Identifieur interne : 002117 ( Istex/Corpus ); précédent : 002116; suivant : 002118Is the psychological impact of genetic testing moderated by support and sharing of test results to family and friends?
Auteurs : Julie Lapointe ; Michel Dorval ; Catherine Noguès ; Roxane Fabre ; Claire Julian-ReynierSource :
- Familial Cancer [ 1389-9600 ] ; 2013-12-01.
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- KwdEn :
Abstract
Abstract: Receiving the results of genetic tests for a breast and ovarian cancer susceptibility can be a stressful experience. Here we studied the effects of social support (SS) and the sharing of test results on the psychological impact of BRCA1/2 test result disclosure. We also compared carriers and non-carriers on sharing, SS and psychological impact. Five-hundred and twenty-two unaffected women were followed prospectively for 2 years after receiving their test results. Psychological impact was measured on the impact of event scale. Multivariate multi-level models were used, and all the analyses were stratified depending on mutation status (carriers vs non-carriers). Two weeks after receiving their BRCA1/2 results, carriers had shared their test results less frequently than non-carriers (p < 0.01). Sharing test results was not significantly associated with psychological impact. Availability of SS was significantly associated with better psychological adjustment across time among carriers (p < 0.01), but not among non-carriers. For female BRCA1/2 mutation carriers, the importance of SS should be stressed, and possible ways of enlisting people in their entourage for this purpose should be discussed in the context of clinical encounters.
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DOI: 10.1007/s10689-013-9621-3
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ISTEX:8EFB58EE42CC5335083CC3AB7B2D53EC426ED215Le document en format XML
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Here we studied the effects of social support (SS) and the sharing of test results on the psychological impact of BRCA1/2 test result disclosure. We also compared carriers and non-carriers on sharing, SS and psychological impact. Five-hundred and twenty-two unaffected women were followed prospectively for 2 years after receiving their test results. Psychological impact was measured on the impact of event scale. Multivariate multi-level models were used, and all the analyses were stratified depending on mutation status (carriers vs non-carriers). Two weeks after receiving their BRCA1/2 results, carriers had shared their test results less frequently than non-carriers (p < 0.01). Sharing test results was not significantly associated with psychological impact. Availability of SS was significantly associated with better psychological adjustment across time among carriers (p < 0.01), but not among non-carriers. For female BRCA1/2 mutation carriers, the importance of SS should be stressed, and possible ways of enlisting people in their entourage for this purpose should be discussed in the context of clinical encounters.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Julie Lapointe</name><affiliations><json:string>Faculté de Pharmacie, Université Laval, 1050, avenue de la Médecine, G1V 0A6, Quebec, QC, Canada</json:string><json:string>URESP, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, 1050, chemin Ste-Foy, G1S 4L8, Quebec, QC, Canada</json:string></affiliations></json:item><json:item><name>Michel Dorval</name><affiliations><json:string>Faculté de Pharmacie, Université Laval, 1050, avenue de la Médecine, G1V 0A6, Quebec, QC, Canada</json:string><json:string>URESP, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, 1050, chemin Ste-Foy, G1S 4L8, Quebec, QC, Canada</json:string><json:string>Centre des Maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, 1050, chemin Ste-Foy, G1S 4L8, Quebec, QC, Canada</json:string></affiliations></json:item><json:item><name>Catherine Noguès</name><affiliations><json:string>Centre René Huguenin, 35, rue Dailly, 92210, Saint-Cloud, France</json:string><json:string>Institut Curie, 26, rue d’Ulm, 75005, Paris, France</json:string></affiliations></json:item><json:item><name>Roxane Fabre</name><affiliations><json:string>Inserm, U912, Marseille, France</json:string><json:string>Aix-Marseille Université, U912, Marseille, France</json:string><json:string>IRD, U912, Marseille, France</json:string></affiliations></json:item><json:item><name>Claire Julian-Reynier</name><affiliations><json:string>Inserm, U912, Marseille, France</json:string><json:string>Aix-Marseille Université, U912, Marseille, France</json:string><json:string>IRD, U912, Marseille, France</json:string><json:string>Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, BP 156, 13273, Marseille Cedex 9, France</json:string><json:string>E-mail: claire.julian-reynier@inserm.fr</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Breast and ovarian cancer</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Family communication</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Hereditary cancer</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Psychological distress</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Social support</value></json:item></subject><articleId><json:string>9621</json:string><json:string>s10689-013-9621-3</json:string></articleId><arkIstex>ark:/67375/VQC-C3LVT8CQ-3</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Receiving the results of genetic tests for a breast and ovarian cancer susceptibility can be a stressful experience. 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general</JournalSubject><SubjectCollection Code="SC3">Biomedical and Life Sciences</SubjectCollection></JournalSubjectGroup></JournalInfo><Volume OutputMedium="All"><VolumeInfo TocLevels="0" VolumeType="Regular"><VolumeIDStart>12</VolumeIDStart><VolumeIDEnd>12</VolumeIDEnd><VolumeIssueCount>4</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular" OutputMedium="All"><IssueInfo IssueType="Regular" TocLevels="0"><IssueIDStart>4</IssueIDStart><IssueIDEnd>4</IssueIDEnd><IssueArticleCount>23</IssueArticleCount><IssueHistory><OnlineDate><Year>2013</Year><Month>11</Month><Day>9</Day></OnlineDate><PrintDate><Year>2013</Year><Month>11</Month><Day>8</Day></PrintDate><CoverDate><Year>2013</Year><Month>12</Month></CoverDate><PricelistYear>2013</PricelistYear></IssueHistory><IssueCopyright><CopyrightHolderName>Springer Science+Business Media Dordrecht</CopyrightHolderName><CopyrightYear>2013</CopyrightYear></IssueCopyright></IssueInfo><Article ID="s10689-013-9621-3" OutputMedium="All"><ArticleInfo ArticleType="OriginalPaper" ContainsESM="No" Language="En" NumberingStyle="Unnumbered" TocLevels="0"><ArticleID>9621</ArticleID><ArticleDOI>10.1007/s10689-013-9621-3</ArticleDOI><ArticleSequenceNumber>3</ArticleSequenceNumber><ArticleTitle Language="En" OutputMedium="All">Is the psychological impact of genetic testing moderated by support and sharing of test results to family and friends?</ArticleTitle><ArticleCategory>Original Article</ArticleCategory><ArticleFirstPage>601</ArticleFirstPage><ArticleLastPage>610</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2013</Year><Month>2</Month><Day>25</Day></RegistrationDate><OnlineDate><Year>2013</Year><Month>3</Month><Day>9</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer Science+Business Media Dordrecht</CopyrightHolderName><CopyrightYear>2013</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1 Aff2"><AuthorName DisplayOrder="Western"><GivenName>Julie</GivenName><FamilyName>Lapointe</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1 Aff2 Aff3"><AuthorName DisplayOrder="Western"><GivenName>Michel</GivenName><FamilyName>Dorval</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff4 Aff5"><AuthorName DisplayOrder="Western"><GivenName>Catherine</GivenName><FamilyName>Noguès</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff6 Aff7 Aff8"><AuthorName DisplayOrder="Western"><GivenName>Roxane</GivenName><FamilyName>Fabre</FamilyName></AuthorName></Author><InstitutionalAuthor><InstitutionalAuthorName>GENEPSO Cohort</InstitutionalAuthorName></InstitutionalAuthor><Author AffiliationIDS="Aff6 Aff7 Aff8 Aff9" CorrespondingAffiliationID="Aff9"><AuthorName DisplayOrder="Western"><GivenName>Claire</GivenName><FamilyName>Julian-Reynier</FamilyName></AuthorName><Contact><Phone>+33-0491-223502</Phone><Fax>+33-0491-223504</Fax><Email>claire.julian-reynier@inserm.fr</Email></Contact></Author><Affiliation ID="Aff1"><OrgDivision>Faculté de Pharmacie</OrgDivision><OrgName>Université Laval</OrgName><OrgAddress><Street>1050, avenue de la Médecine</Street><City>Quebec</City><State>QC</State><Postcode>G1V 0A6</Postcode><Country Code="CA">Canada</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>URESP</OrgDivision><OrgName>Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec</OrgName><OrgAddress><Street>1050, chemin Ste-Foy</Street><City>Quebec</City><State>QC</State><Postcode>G1S 4L8</Postcode><Country Code="CA">Canada</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Centre des Maladies du sein Deschênes-Fabia</OrgDivision><OrgName>Hôpital du Saint-Sacrement</OrgName><OrgAddress><Street>1050, chemin Ste-Foy</Street><City>Quebec</City><State>QC</State><Postcode>G1S 4L8</Postcode><Country Code="CA">Canada</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgName>Centre René Huguenin</OrgName><OrgAddress><Street>35, rue Dailly</Street><Postcode>92210</Postcode><City>Saint-Cloud</City><Country Code="FR">France</Country></OrgAddress></Affiliation><Affiliation ID="Aff5"><OrgName>Institut Curie</OrgName><OrgAddress><Street>26, rue d’Ulm</Street><Postcode>75005</Postcode><City>Paris</City><Country Code="FR">France</Country></OrgAddress></Affiliation><Affiliation ID="Aff6"><OrgName>Inserm, U912</OrgName><OrgAddress><City>Marseille</City><Country Code="FR">France</Country></OrgAddress></Affiliation><Affiliation ID="Aff7"><OrgName>Aix-Marseille Université, U912</OrgName><OrgAddress><City>Marseille</City><Country Code="FR">France</Country></OrgAddress></Affiliation><Affiliation ID="Aff8"><OrgName>IRD, U912</OrgName><OrgAddress><City>Marseille</City><Country Code="FR">France</Country></OrgAddress></Affiliation><Affiliation ID="Aff9"><OrgName>Institut Paoli-Calmettes</OrgName><OrgAddress><Street>232 Boulevard Sainte Marguerite, BP 156</Street><Postcode>13273</Postcode><City>Marseille Cedex 9</City><Country Code="FR">France</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><Para>Receiving the results of genetic tests for a breast and ovarian cancer susceptibility can be a stressful experience. Here we studied the effects of social support (SS) and the sharing of test results on the psychological impact of <Emphasis Type="Italic">BRCA1</Emphasis>/<Emphasis Type="Italic">2</Emphasis> test result disclosure. We also compared carriers and non-carriers on sharing, SS and psychological impact. Five-hundred and twenty-two unaffected women were followed prospectively for 2 years after receiving their test results. Psychological impact was measured on the impact of event scale. Multivariate multi-level models were used, and all the analyses were stratified depending on mutation status (carriers vs non-carriers). Two weeks after receiving their <Emphasis Type="Italic">BRCA1</Emphasis>/<Emphasis Type="Italic">2</Emphasis> results, carriers had shared their test results less frequently than non-carriers (<Emphasis Type="Italic">p</Emphasis> < 0.01). Sharing test results was not significantly associated with psychological impact. Availability of SS was significantly associated with better psychological adjustment across time among carriers (<Emphasis Type="Italic">p</Emphasis> < 0.01), but not among non-carriers. For female <Emphasis Type="Italic">BRCA1</Emphasis>/<Emphasis Type="Italic">2</Emphasis> mutation carriers, the importance of SS should be stressed, and possible ways of enlisting people in their entourage for this purpose should be discussed in the context of clinical encounters.</Para></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Breast and ovarian cancer</Keyword><Keyword>Family communication</Keyword><Keyword>Hereditary cancer</Keyword><Keyword>Psychological distress</Keyword><Keyword>Social support</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara>The members of the GENEPSO Cohort study is given in “Appendix”.</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Is the psychological impact of genetic testing moderated by support and sharing of test results to family and friends?</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Is the psychological impact of genetic testing moderated by support and sharing of test results to family and friends?</title></titleInfo><name type="corporate"><namePart>GENEPSO Cohort</namePart></name><name type="personal"><namePart type="given">Julie</namePart><namePart type="family">Lapointe</namePart><affiliation>Faculté de Pharmacie, Université Laval, 1050, avenue de la Médecine, G1V 0A6, Quebec, QC, Canada</affiliation><affiliation>URESP, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, 1050, chemin Ste-Foy, G1S 4L8, Quebec, QC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michel</namePart><namePart type="family">Dorval</namePart><affiliation>Faculté de Pharmacie, Université Laval, 1050, avenue de la Médecine, G1V 0A6, Quebec, QC, Canada</affiliation><affiliation>URESP, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, 1050, chemin Ste-Foy, G1S 4L8, Quebec, QC, Canada</affiliation><affiliation>Centre des Maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, 1050, chemin Ste-Foy, G1S 4L8, Quebec, QC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Catherine</namePart><namePart type="family">Noguès</namePart><affiliation>Centre René Huguenin, 35, rue Dailly, 92210, Saint-Cloud, France</affiliation><affiliation>Institut Curie, 26, rue d’Ulm, 75005, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roxane</namePart><namePart type="family">Fabre</namePart><affiliation>Inserm, U912, Marseille, France</affiliation><affiliation>Aix-Marseille Université, U912, Marseille, France</affiliation><affiliation>IRD, U912, Marseille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Claire</namePart><namePart type="family">Julian-Reynier</namePart><affiliation>Inserm, U912, Marseille, France</affiliation><affiliation>Aix-Marseille Université, U912, Marseille, France</affiliation><affiliation>IRD, U912, Marseille, France</affiliation><affiliation>Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, BP 156, 13273, Marseille Cedex 9, France</affiliation><affiliation>E-mail: claire.julian-reynier@inserm.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer Netherlands</publisher><place><placeTerm type="text">Dordrecht</placeTerm></place><dateIssued encoding="w3cdtf">2013-12-01</dateIssued><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Receiving the results of genetic tests for a breast and ovarian cancer susceptibility can be a stressful experience. Here we studied the effects of social support (SS) and the sharing of test results on the psychological impact of BRCA1/2 test result disclosure. We also compared carriers and non-carriers on sharing, SS and psychological impact. Five-hundred and twenty-two unaffected women were followed prospectively for 2 years after receiving their test results. Psychological impact was measured on the impact of event scale. Multivariate multi-level models were used, and all the analyses were stratified depending on mutation status (carriers vs non-carriers). Two weeks after receiving their BRCA1/2 results, carriers had shared their test results less frequently than non-carriers (p < 0.01). Sharing test results was not significantly associated with psychological impact. Availability of SS was significantly associated with better psychological adjustment across time among carriers (p < 0.01), but not among non-carriers. For female BRCA1/2 mutation carriers, the importance of SS should be stressed, and possible ways of enlisting people in their entourage for this purpose should be discussed in the context of clinical encounters.</abstract><note>Original Article</note><subject lang="en"><genre>Keywords</genre><topic>Breast and ovarian cancer</topic><topic>Family communication</topic><topic>Hereditary cancer</topic><topic>Psychological distress</topic><topic>Social support</topic></subject><relatedItem type="host"><titleInfo><title>Familial Cancer</title></titleInfo><titleInfo type="abbreviated"><title>Familial Cancer</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2013-11-09</dateIssued><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><subject><genre>Journal-Subject-Collection</genre><topic authority="SpringerSubjectCodes" authorityURI="SC3">Biomedical and Life Sciences</topic></subject><subject><genre>Journal-Subject-Group</genre><topic authority="SpringerSubjectCodes" authorityURI="SCB">Biomedicine</topic><topic authority="SpringerSubjectCodes" authorityURI="SCB11001">Cancer Research</topic><topic authority="SpringerSubjectCodes" authorityURI="SCB12008">Human Genetics</topic><topic authority="SpringerSubjectCodes" authorityURI="SCH63000">Epidemiology</topic><topic authority="SpringerSubjectCodes" authorityURI="SCB0000X">Biomedicine general</topic></subject><identifier type="ISSN">1389-9600</identifier><identifier type="eISSN">1573-7292</identifier><identifier type="JournalID">10689</identifier><identifier type="IssueArticleCount">23</identifier><identifier type="VolumeIssueCount">4</identifier><part><date>2013</date><detail type="volume"><number>12</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="pages"><start>601</start><end>610</end></extent></part><recordInfo><recordOrigin>Springer Science+Business Media Dordrecht, 2013</recordOrigin></recordInfo></relatedItem><identifier type="istex">8EFB58EE42CC5335083CC3AB7B2D53EC426ED215</identifier><identifier type="ark">ark:/67375/VQC-C3LVT8CQ-3</identifier><identifier type="DOI">10.1007/s10689-013-9621-3</identifier><identifier type="ArticleID">9621</identifier><identifier type="ArticleID">s10689-013-9621-3</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer Science+Business Media Dordrecht, 2013</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer Science+Business Media Dordrecht, 2013</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-C3LVT8CQ-3/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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