Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work‐up, and treatment for patients till the age of 18 years
Identifieur interne : 000093 ( Istex/Corpus ); précédent : 000092; suivant : 000094Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work‐up, and treatment for patients till the age of 18 years
Auteurs : Riccardo Haupt ; Milen Minkov ; Itziar Astigarraga ; Eva Sch Fer ; Vasanta Nanduri ; Rima Jubran ; R. Maarten Egeler ; Gritta Janka ; Dragan Micic ; Carlos Rodriguez-Galindo ; Stefaan Van Gool ; Johannes Visser ; Sheila Weitzman ; Jean DonadieuSource :
- Pediatric Blood & Cancer [ 1545-5009 ] ; 2013-02.
English descriptors
- Teeft :
- Active disease, Additional testing, Alanine transaminase, Anna hospital, Aspartate transaminase, Assistance publique hopitaux, Biopsy, Birbeck granules, Bone involvement, Bone lesions, Bone marrow, Bone scan, Bronchoalveolar lavage, Cambridge university press, Cancer research institute, Cell histiocytosis, Cell transplantation, Cerebellar function assessment, Cerebellar syndrome, Childhood cancer survivors, Childrens hospital, Clavicular line, Clinical classification, Clinical course, Clinical findings, Coagulation studies, Complete resolution, Consensus guidelines, Costal margin, Dental development, Diabetes insipidus, Disease activity, Disease form, Disease progression, Donadieu, Dysfunction, Egeler, Euro histio, General agreement, Gritta janka, Growth failure, Growth hormone, Guideline, Haupt, Hemophagocytic syndrome, High resolution, Histiocyte society, Histiocytic, Histiocytic disorders, Histiocytosis, Hopital trousseau, Hospital universitario cruces barakaldo, Imaging, Insipidus, Intravenous immunoglobulin, Involvement, Iron deficiency, Itziar astigarraga, Jean donadieu, Langerhans, Langerhans cell histiocytosis, Lesion, Liver enzymes, Liver involvement, Lung involvement, Lymph, Lymph node, Lymph nodes, Macrophage activation, Magnetic resonance imaging, Main endpoint, Milen minkov, Multisystem, Multisystem langerhans cell histiocytosis, Neurological, Node, Nodule, Oncol, Organ involvement, Orthopedic surgeon, Other causes, Other organs, Oxaloacetic transaminase, Pediatr, Pediatr blood cancer, Pediatr oncol, Pediatr orthop, Permanent consequences, Pilot study, Pubertal development, Puberty, Pulmonary involvement, Pyruvic transaminase, Radiation therapy, Rapid growth, Rare cases, Rare disease, Research society, Risk factors, Risk lesions, Risk organ, Risk organ involvement, Risk organs, Sclerosing cholangitis, Sequela, Sheila weitzman, Sick children, Single system, Skeletal radiograph, Skin rash, Skull base, Steroid, Such patients need, Syndrome, System langerhans cell histiocytosis, Systemic therapy, Temporal bone, Tissue extension, Tomography, Topical steroids, Transaminase, Treatment options, Vasanta nanduri, Vertebra plana, Vertebral involvement, Weekly bolus, Weitzman, Wiley periodicals, Young children.
Abstract
These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work‐up, and treatment and long‐term follow‐up of LCH patients are presented. Pediatr Blood Cancer 2013;60:175–184. © 2012 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc.
Url:
DOI: 10.1002/pbc.24367
Links to Exploration step
ISTEX:04AF7C0F91AFDA48174DBCF78A4FF3B37FF99CA2Le document en format XML
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Gaslini, Genova, Italy</mods:affiliation></affiliation></author><author><name sortKey="Minkov, Milen" sort="Minkov, Milen" uniqKey="Minkov M" first="Milen" last="Minkov">Milen Minkov</name><affiliation><mods:affiliation>Children's Cancer Research Institute, St. Anna Children's Hospital, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Astigarraga, Itziar" sort="Astigarraga, Itziar" uniqKey="Astigarraga I" first="Itziar" last="Astigarraga">Itziar Astigarraga</name><affiliation><mods:affiliation>Hospital Universitario Cruces Barakaldo, Barakaldo, Spain</mods:affiliation></affiliation></author><author><name sortKey="Sch Fer, Eva" sort="Sch Fer, Eva" uniqKey="Sch Fer E" first="Eva" last="Sch Fer">Eva Sch Fer</name><affiliation><mods:affiliation>Reference Centre for Histiocytosis at Hopital Trousseau, Assistance Publique – Hopitaux de Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Nanduri, Vasanta" sort="Nanduri, Vasanta" uniqKey="Nanduri V" first="Vasanta" last="Nanduri">Vasanta Nanduri</name><affiliation><mods:affiliation>Watford General Hospital, Watford, UK</mods:affiliation></affiliation></author><author><name sortKey="Jubran, Rima" sort="Jubran, Rima" uniqKey="Jubran R" first="Rima" last="Jubran">Rima Jubran</name><affiliation><mods:affiliation>Children's Hospital of Los Angeles, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Egeler, R Maarten" sort="Egeler, R Maarten" uniqKey="Egeler R" first="R. Maarten" last="Egeler">R. Maarten Egeler</name><affiliation><mods:affiliation>Hospital for Sick Children, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Janka, Gritta" sort="Janka, Gritta" uniqKey="Janka G" first="Gritta" last="Janka">Gritta Janka</name><affiliation><mods:affiliation>University Medical Center Hamburg‐Eppendorf, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Micic, Dragan" sort="Micic, Dragan" uniqKey="Micic D" first="Dragan" last="Micic">Dragan Micic</name><affiliation><mods:affiliation>Mother and Child Health Institute of Serbia “Dr Vukan Cupic,” Belgrade, Serbia</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez Alindo, Carlos" sort="Rodriguez Alindo, Carlos" uniqKey="Rodriguez Alindo C" first="Carlos" last="Rodriguez-Galindo">Carlos Rodriguez-Galindo</name><affiliation><mods:affiliation>Dana Farber Cancer Institute, Children's Hospital Boston, Boston, Massachusetts</mods:affiliation></affiliation></author><author><name sortKey="Van Gool, Stefaan" sort="Van Gool, Stefaan" uniqKey="Van Gool S" first="Stefaan" last="Van Gool">Stefaan Van Gool</name><affiliation><mods:affiliation>University Hospital Gasthuisberg, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Visser, Johannes" sort="Visser, Johannes" uniqKey="Visser J" first="Johannes" last="Visser">Johannes Visser</name><affiliation><mods:affiliation>University Hospitals of Leicester, Leicester Children's Hospital, Leicester, UK</mods:affiliation></affiliation></author><author><name sortKey="Weitzman, Sheila" sort="Weitzman, Sheila" uniqKey="Weitzman S" first="Sheila" last="Weitzman">Sheila Weitzman</name><affiliation><mods:affiliation>Hospital for Sick Children, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Donadieu, Jean" sort="Donadieu, Jean" uniqKey="Donadieu J" first="Jean" last="Donadieu">Jean Donadieu</name><affiliation><mods:affiliation>Reference Centre for Histiocytosis at Hopital Trousseau, Assistance Publique – Hopitaux de Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: jean.donadieu@trs.aphp.fr</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Service d'Hémato Oncologie Pédiatrique, Hopital Trousseau, 26 avenue du Dr Netter, F 75012 Paris, France.===</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:04AF7C0F91AFDA48174DBCF78A4FF3B37FF99CA2</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/pbc.24367</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-JJPNL9LG-T/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000093</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000093</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work‐up, and treatment for patients till the age of 18 years<ref type="note" target="#fn1"></ref></title><author><name sortKey="Haupt, Riccardo" sort="Haupt, Riccardo" uniqKey="Haupt R" first="Riccardo" last="Haupt">Riccardo Haupt</name><affiliation><mods:affiliation>Department of Hematology and Oncology, Epidemiology and Biostatistics Section, Istituto G. Gaslini, Genova, Italy</mods:affiliation></affiliation></author><author><name sortKey="Minkov, Milen" sort="Minkov, Milen" uniqKey="Minkov M" first="Milen" last="Minkov">Milen Minkov</name><affiliation><mods:affiliation>Children's Cancer Research Institute, St. Anna Children's Hospital, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Astigarraga, Itziar" sort="Astigarraga, Itziar" uniqKey="Astigarraga I" first="Itziar" last="Astigarraga">Itziar Astigarraga</name><affiliation><mods:affiliation>Hospital Universitario Cruces Barakaldo, Barakaldo, Spain</mods:affiliation></affiliation></author><author><name sortKey="Sch Fer, Eva" sort="Sch Fer, Eva" uniqKey="Sch Fer E" first="Eva" last="Sch Fer">Eva Sch Fer</name><affiliation><mods:affiliation>Reference Centre for Histiocytosis at Hopital Trousseau, Assistance Publique – Hopitaux de Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Nanduri, Vasanta" sort="Nanduri, Vasanta" uniqKey="Nanduri V" first="Vasanta" last="Nanduri">Vasanta Nanduri</name><affiliation><mods:affiliation>Watford General Hospital, Watford, UK</mods:affiliation></affiliation></author><author><name sortKey="Jubran, Rima" sort="Jubran, Rima" uniqKey="Jubran R" first="Rima" last="Jubran">Rima Jubran</name><affiliation><mods:affiliation>Children's Hospital of Los Angeles, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Egeler, R Maarten" sort="Egeler, R Maarten" uniqKey="Egeler R" first="R. Maarten" last="Egeler">R. Maarten Egeler</name><affiliation><mods:affiliation>Hospital for Sick Children, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Janka, Gritta" sort="Janka, Gritta" uniqKey="Janka G" first="Gritta" last="Janka">Gritta Janka</name><affiliation><mods:affiliation>University Medical Center Hamburg‐Eppendorf, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Micic, Dragan" sort="Micic, Dragan" uniqKey="Micic D" first="Dragan" last="Micic">Dragan Micic</name><affiliation><mods:affiliation>Mother and Child Health Institute of Serbia “Dr Vukan Cupic,” Belgrade, Serbia</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez Alindo, Carlos" sort="Rodriguez Alindo, Carlos" uniqKey="Rodriguez Alindo C" first="Carlos" last="Rodriguez-Galindo">Carlos Rodriguez-Galindo</name><affiliation><mods:affiliation>Dana Farber Cancer Institute, Children's Hospital Boston, Boston, Massachusetts</mods:affiliation></affiliation></author><author><name sortKey="Van Gool, Stefaan" sort="Van Gool, Stefaan" uniqKey="Van Gool S" first="Stefaan" last="Van Gool">Stefaan Van Gool</name><affiliation><mods:affiliation>University Hospital Gasthuisberg, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Visser, Johannes" sort="Visser, Johannes" uniqKey="Visser J" first="Johannes" last="Visser">Johannes Visser</name><affiliation><mods:affiliation>University Hospitals of Leicester, Leicester Children's Hospital, Leicester, UK</mods:affiliation></affiliation></author><author><name sortKey="Weitzman, Sheila" sort="Weitzman, Sheila" uniqKey="Weitzman S" first="Sheila" last="Weitzman">Sheila Weitzman</name><affiliation><mods:affiliation>Hospital for Sick Children, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Donadieu, Jean" sort="Donadieu, Jean" uniqKey="Donadieu J" first="Jean" last="Donadieu">Jean Donadieu</name><affiliation><mods:affiliation>Reference Centre for Histiocytosis at Hopital Trousseau, Assistance Publique – Hopitaux de Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: jean.donadieu@trs.aphp.fr</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Service d'Hémato Oncologie Pédiatrique, Hopital Trousseau, 26 avenue du Dr Netter, F 75012 Paris, France.===</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pediatric Blood & Cancer</title><title level="j" type="alt">PEDIATRIC BLOOD AND CANCER</title><idno type="ISSN">1545-5009</idno><idno type="eISSN">1545-5017</idno><imprint><biblScope unit="vol">60</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="175">175</biblScope><biblScope unit="page" to="184">184</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2013-02">2013-02</date></imprint><idno type="ISSN">1545-5009</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1545-5009</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Active disease</term><term>Additional testing</term><term>Alanine transaminase</term><term>Anna hospital</term><term>Aspartate transaminase</term><term>Assistance publique hopitaux</term><term>Biopsy</term><term>Birbeck granules</term><term>Bone involvement</term><term>Bone lesions</term><term>Bone marrow</term><term>Bone scan</term><term>Bronchoalveolar lavage</term><term>Cambridge university press</term><term>Cancer research institute</term><term>Cell histiocytosis</term><term>Cell transplantation</term><term>Cerebellar function assessment</term><term>Cerebellar syndrome</term><term>Childhood cancer survivors</term><term>Childrens hospital</term><term>Clavicular line</term><term>Clinical classification</term><term>Clinical course</term><term>Clinical findings</term><term>Coagulation studies</term><term>Complete resolution</term><term>Consensus guidelines</term><term>Costal margin</term><term>Dental development</term><term>Diabetes insipidus</term><term>Disease activity</term><term>Disease form</term><term>Disease progression</term><term>Donadieu</term><term>Dysfunction</term><term>Egeler</term><term>Euro histio</term><term>General agreement</term><term>Gritta janka</term><term>Growth failure</term><term>Growth hormone</term><term>Guideline</term><term>Haupt</term><term>Hemophagocytic syndrome</term><term>High resolution</term><term>Histiocyte society</term><term>Histiocytic</term><term>Histiocytic disorders</term><term>Histiocytosis</term><term>Hopital trousseau</term><term>Hospital universitario cruces barakaldo</term><term>Imaging</term><term>Insipidus</term><term>Intravenous immunoglobulin</term><term>Involvement</term><term>Iron deficiency</term><term>Itziar astigarraga</term><term>Jean donadieu</term><term>Langerhans</term><term>Langerhans cell histiocytosis</term><term>Lesion</term><term>Liver enzymes</term><term>Liver involvement</term><term>Lung involvement</term><term>Lymph</term><term>Lymph node</term><term>Lymph nodes</term><term>Macrophage activation</term><term>Magnetic resonance imaging</term><term>Main endpoint</term><term>Milen minkov</term><term>Multisystem</term><term>Multisystem langerhans cell histiocytosis</term><term>Neurological</term><term>Node</term><term>Nodule</term><term>Oncol</term><term>Organ involvement</term><term>Orthopedic surgeon</term><term>Other causes</term><term>Other organs</term><term>Oxaloacetic transaminase</term><term>Pediatr</term><term>Pediatr blood cancer</term><term>Pediatr oncol</term><term>Pediatr orthop</term><term>Permanent consequences</term><term>Pilot study</term><term>Pubertal development</term><term>Puberty</term><term>Pulmonary involvement</term><term>Pyruvic transaminase</term><term>Radiation therapy</term><term>Rapid growth</term><term>Rare cases</term><term>Rare disease</term><term>Research society</term><term>Risk factors</term><term>Risk lesions</term><term>Risk organ</term><term>Risk organ involvement</term><term>Risk organs</term><term>Sclerosing cholangitis</term><term>Sequela</term><term>Sheila weitzman</term><term>Sick children</term><term>Single system</term><term>Skeletal radiograph</term><term>Skin rash</term><term>Skull base</term><term>Steroid</term><term>Such patients need</term><term>Syndrome</term><term>System langerhans cell histiocytosis</term><term>Systemic therapy</term><term>Temporal bone</term><term>Tissue extension</term><term>Tomography</term><term>Topical steroids</term><term>Transaminase</term><term>Treatment options</term><term>Vasanta nanduri</term><term>Vertebra plana</term><term>Vertebral involvement</term><term>Weekly bolus</term><term>Weitzman</term><term>Wiley periodicals</term><term>Young children</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work‐up, and treatment and long‐term follow‐up of LCH patients are presented. Pediatr Blood Cancer 2013;60:175–184. © 2012 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>histiocytosis</json:string><json:string>langerhans</json:string><json:string>pediatr</json:string><json:string>langerhans cell histiocytosis</json:string><json:string>pediatr blood cancer</json:string><json:string>guideline</json:string><json:string>lesion</json:string><json:string>insipidus</json:string><json:string>risk organs</json:string><json:string>oncol</json:string><json:string>egeler</json:string><json:string>haupt</json:string><json:string>diabetes insipidus</json:string><json:string>histiocytic</json:string><json:string>sequela</json:string><json:string>systemic therapy</json:string><json:string>donadieu</json:string><json:string>multisystem</json:string><json:string>weitzman</json:string><json:string>dysfunction</json:string><json:string>tomography</json:string><json:string>nodule</json:string><json:string>pediatr oncol</json:string><json:string>cell histiocytosis</json:string><json:string>node</json:string><json:string>permanent consequences</json:string><json:string>steroid</json:string><json:string>multisystem langerhans cell histiocytosis</json:string><json:string>magnetic resonance imaging</json:string><json:string>euro histio</json:string><json:string>disease activity</json:string><json:string>cambridge university press</json:string><json:string>histiocytic disorders</json:string><json:string>clinical findings</json:string><json:string>lung involvement</json:string><json:string>research society</json:string><json:string>transaminase</json:string><json:string>puberty</json:string><json:string>biopsy</json:string><json:string>neurological</json:string><json:string>imaging</json:string><json:string>vertebra plana</json:string><json:string>birbeck granules</json:string><json:string>sclerosing cholangitis</json:string><json:string>organ involvement</json:string><json:string>risk lesions</json:string><json:string>young children</json:string><json:string>tissue extension</json:string><json:string>other causes</json:string><json:string>macrophage activation</json:string><json:string>pulmonary involvement</json:string><json:string>temporal bone</json:string><json:string>growth hormone</json:string><json:string>bone marrow</json:string><json:string>risk factors</json:string><json:string>hopital trousseau</json:string><json:string>involvement</json:string><json:string>rare disease</json:string><json:string>skeletal radiograph</json:string><json:string>jean donadieu</json:string><json:string>alanine transaminase</json:string><json:string>pyruvic transaminase</json:string><json:string>aspartate transaminase</json:string><json:string>oxaloacetic transaminase</json:string><json:string>main endpoint</json:string><json:string>general agreement</json:string><json:string>bone scan</json:string><json:string>hospital universitario cruces barakaldo</json:string><json:string>growth failure</json:string><json:string>hemophagocytic syndrome</json:string><json:string>histiocyte society</json:string><json:string>liver enzymes</json:string><json:string>system langerhans cell histiocytosis</json:string><json:string>clinical classification</json:string><json:string>anna hospital</json:string><json:string>bronchoalveolar lavage</json:string><json:string>skull base</json:string><json:string>cancer research institute</json:string><json:string>additional testing</json:string><json:string>high resolution</json:string><json:string>assistance publique hopitaux</json:string><json:string>sick children</json:string><json:string>risk organ</json:string><json:string>lymph node</json:string><json:string>bone involvement</json:string><json:string>rare cases</json:string><json:string>cerebellar syndrome</json:string><json:string>iron deficiency</json:string><json:string>costal margin</json:string><json:string>clavicular line</json:string><json:string>bone lesions</json:string><json:string>orthopedic surgeon</json:string><json:string>vertebral involvement</json:string><json:string>disease progression</json:string><json:string>treatment options</json:string><json:string>disease form</json:string><json:string>clinical course</json:string><json:string>lymph nodes</json:string><json:string>skin rash</json:string><json:string>topical steroids</json:string><json:string>single system</json:string><json:string>complete resolution</json:string><json:string>active disease</json:string><json:string>risk organ involvement</json:string><json:string>weekly bolus</json:string><json:string>such patients need</json:string><json:string>cell transplantation</json:string><json:string>intravenous immunoglobulin</json:string><json:string>coagulation studies</json:string><json:string>consensus guidelines</json:string><json:string>radiation therapy</json:string><json:string>other organs</json:string><json:string>rapid growth</json:string><json:string>dental development</json:string><json:string>cerebellar function assessment</json:string><json:string>pubertal development</json:string><json:string>liver involvement</json:string><json:string>childhood cancer survivors</json:string><json:string>childrens hospital</json:string><json:string>wiley periodicals</json:string><json:string>sheila weitzman</json:string><json:string>gritta janka</json:string><json:string>vasanta nanduri</json:string><json:string>itziar astigarraga</json:string><json:string>milen minkov</json:string><json:string>pediatr orthop</json:string><json:string>pilot study</json:string><json:string>syndrome</json:string><json:string>lymph</json:string></teeft></keywords><author><json:item><name>Riccardo Haupt MD</name><affiliations><json:string>Department of Hematology and Oncology, Epidemiology and Biostatistics Section, Istituto G. Gaslini, Genova, Italy</json:string></affiliations></json:item><json:item><name>Milen Minkov MD</name><affiliations><json:string>Children's Cancer Research Institute, St. Anna Children's Hospital, Vienna, Austria</json:string></affiliations></json:item><json:item><name>Itziar Astigarraga MD</name><affiliations><json:string>Hospital Universitario Cruces Barakaldo, Barakaldo, Spain</json:string></affiliations></json:item><json:item><name>Eva Schäfer MSc</name><affiliations><json:string>Reference Centre for Histiocytosis at Hopital Trousseau, Assistance Publique – Hopitaux de Paris, France</json:string></affiliations></json:item><json:item><name>Vasanta Nanduri MD</name><affiliations><json:string>Watford General Hospital, Watford, UK</json:string></affiliations></json:item><json:item><name>Rima Jubran MD</name><affiliations><json:string>Children's Hospital of Los Angeles, Los Angeles, California</json:string></affiliations></json:item><json:item><name>R. 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Maarten</forename><surname>Egeler</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation><address><addrLine>Hospital for Sick Children</addrLine><addrLine>Toronto</addrLine><addrLine>Ontario</addrLine><country key="CA">CANADA</country><country key="CA"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Gritta</forename><surname>Janka</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName type="institution">University Medical Center Hamburg‐Eppendorf</orgName><address><addrLine>Hamburg</addrLine><country key="DE">GERMANY</country><country key="DE"></country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Dragan</forename><surname>Micic</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName type="institution">Mother and Child Health Institute of Serbia “Dr Vukan Cupic</orgName><address><addrLine>” Belgrade</addrLine><country key="RS">SERBIA</country><country key="RS"></country></address></affiliation></author><author xml:id="author-0009"><persName><forename type="first">Carlos</forename><surname>Rodriguez‐Galindo</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName type="institution">Dana Farber Cancer Institute</orgName><address><addrLine>Children's Hospital Boston</addrLine><addrLine>Boston</addrLine><addrLine>Massachusetts</addrLine><country key="US"></country></address></affiliation></author><author xml:id="author-0010"><persName><forename type="first">Stefaan</forename><surname>Van Gool</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName type="institution">University Hospital Gasthuisberg</orgName><address><addrLine>Leuven</addrLine><country key="BE">BELGIUM</country><country key="BE"></country></address></affiliation></author><author xml:id="author-0011"><persName><forename type="first">Johannes</forename><surname>Visser</surname><roleName type="degree">MBChB</roleName></persName><affiliation><orgName type="institution">University Hospitals of Leicester</orgName><address><addrLine>Leicester Children's Hospital</addrLine><addrLine>Leicester</addrLine><country key="GB">UNITED KINGDOM</country><country key="GB"></country></address></affiliation></author><author xml:id="author-0012"><persName><forename type="first">Sheila</forename><surname>Weitzman</surname><roleName type="degree">MD</roleName></persName><affiliation><address><addrLine>Hospital for Sick Children</addrLine><addrLine>Toronto</addrLine><addrLine>Ontario</addrLine><country key="CA">CANADA</country><country key="CA"></country></address></affiliation></author><author xml:id="author-0013" role="corresp"><persName><forename type="first">Jean</forename><surname>Donadieu</surname><roleName type="degree">MD, PhD</roleName></persName><email>jean.donadieu@trs.aphp.fr</email><affiliation><address><addrLine>Reference Centre for Histiocytosis at Hopital Trousseau</addrLine><addrLine>Assistance Publique – Hopitaux de Paris</addrLine><country key="FR">FRANCE</country><country key="FR"></country></address></affiliation><affiliation>Service d'Hémato Oncologie Pédiatrique, Hopital Trousseau, 26 avenue du Dr Netter, F 75012 Paris, France.===</affiliation></author><author xml:id="author-0014"><author><orgName>for the Euro Histio Network</orgName></author></author><idno type="istex">04AF7C0F91AFDA48174DBCF78A4FF3B37FF99CA2</idno><idno type="ark">ark:/67375/WNG-JJPNL9LG-T</idno><idno type="DOI">10.1002/pbc.24367</idno><idno type="unit">PBC24367</idno><idno type="toTypesetVersion">file:PBC.PBC24367.pdf</idno></analytic><monogr><title level="j" type="main">Pediatric Blood & Cancer</title><title level="j" type="alt">PEDIATRIC BLOOD AND CANCER</title><idno type="pISSN">1545-5009</idno><idno type="eISSN">1545-5017</idno><idno type="book-DOI">10.1002/(ISSN)1545-5017</idno><idno type="book-part-DOI">10.1002/pbc.v60.2</idno><idno type="product">PBC</idno><imprint><biblScope unit="vol">60</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="175">175</biblScope><biblScope unit="page" to="184">184</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2013-02"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. 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</p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:15455009:media:pbc24367:pbc24367-sup-0001-SupplApp"></mediaResource><caption>Supplementary Appendix</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work‐up, and treatment and long‐term follow‐up of LCH patients are presented. Pediatr Blood Cancer 2013;60:175–184. © 2012 The Authors. <i>Pediatric Blood & Cancer</i>, published by Wiley Periodicals, Inc.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn111"><p>[The copyright line for this article was updated in July 2015 after original online publication.]</p></note><note xml:id="fn1"><p>Conflict of interest: Nothing to declare.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work‐up, and treatment for patients till the age of 18 years</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Guidelines for Langerhans Cell Histiocytosis</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work‐up, and treatment for patients till the age of 18 years</title></titleInfo><name type="personal"><namePart type="given">Riccardo</namePart><namePart type="family">Haupt</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Hematology and Oncology, Epidemiology and Biostatistics Section, Istituto G. Gaslini, Genova, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Milen</namePart><namePart type="family">Minkov</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Children's Cancer Research Institute, St. Anna Children's Hospital, Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Itziar</namePart><namePart type="family">Astigarraga</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Hospital Universitario Cruces Barakaldo, Barakaldo, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eva</namePart><namePart type="family">Schäfer</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Reference Centre for Histiocytosis at Hopital Trousseau, Assistance Publique – Hopitaux de Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vasanta</namePart><namePart type="family">Nanduri</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Watford General Hospital, Watford, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rima</namePart><namePart type="family">Jubran</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Children's Hospital of Los Angeles, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. Maarten</namePart><namePart type="family">Egeler</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Hospital for Sick Children, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gritta</namePart><namePart type="family">Janka</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University Medical Center Hamburg‐Eppendorf, Hamburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dragan</namePart><namePart type="family">Micic</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Mother and Child Health Institute of Serbia “Dr Vukan Cupic,” Belgrade, Serbia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlos</namePart><namePart type="family">Rodriguez‐Galindo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dana Farber Cancer Institute, Children's Hospital Boston, Boston, Massachusetts</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stefaan</namePart><namePart type="family">Van Gool</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University Hospital Gasthuisberg, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Johannes</namePart><namePart type="family">Visser</namePart><namePart type="termsOfAddress">MBChB</namePart><affiliation>University Hospitals of Leicester, Leicester Children's Hospital, Leicester, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sheila</namePart><namePart type="family">Weitzman</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Hospital for Sick Children, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean</namePart><namePart type="family">Donadieu</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Reference Centre for Histiocytosis at Hopital Trousseau, Assistance Publique – Hopitaux de Paris, France</affiliation><affiliation>E-mail: jean.donadieu@trs.aphp.fr</affiliation><affiliation>Correspondence address: Service d'Hémato Oncologie Pédiatrique, Hopital Trousseau, 26 avenue du Dr Netter, F 75012 Paris, France.===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>for the Euro Histio Network</namePart><description>Department of Hematology and Oncology, Epidemiology and Biostatistics Section, Istituto G. Gaslini, Genova, ItalyChildren's Cancer Research Institute, St. Anna Children's Hospital, Vienna, AustriaHospital Universitario Cruces Barakaldo, Barakaldo, SpainReference Centre for Histiocytosis at Hopital Trousseau, Assistance Publique – Hopitaux de Paris, FranceWatford General Hospital, Watford, UKChildren's Hospital of Los Angeles, Los Angeles, CaliforniaHospital for Sick Children, Toronto, Ontario, CanadaUniversity Medical Center Hamburg‐Eppendorf, Hamburg, GermanyMother and Child Health Institute of Serbia “Dr Vukan Cupic,” Belgrade, SerbiaDana Farber Cancer Institute, Children's Hospital Boston, Boston, MassachusettsUniversity Hospital Gasthuisberg, Leuven, BelgiumUniversity Hospitals of Leicester, Leicester Children's Hospital, Leicester, UK</description></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="miscellaneous" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2013-02</dateIssued><dateCaptured encoding="w3cdtf">2012-05-13</dateCaptured><dateValid encoding="w3cdtf">2012-09-18</dateValid><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">5</extent><extent unit="references">60</extent><extent unit="words">8672</extent></physicalDescription><abstract lang="en">These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work‐up, and treatment and long‐term follow‐up of LCH patients are presented. Pediatr Blood Cancer 2013;60:175–184. © 2012 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc.</abstract><note type="content">*Conflict of interest: Nothing to declare.</note><subject lang="en"><genre>keywords</genre><topic>clinical work‐up</topic><topic>diagnosis</topic><topic>follow‐up</topic><topic>guidelines</topic><topic>Langerhans cell histiocytosis</topic><topic>therapy</topic></subject><relatedItem type="host"><titleInfo><title>Pediatric Blood & Cancer</title></titleInfo><titleInfo type="abbreviated"><title>Pediatr. 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