The glutathione-related detoxification pathway in the human breast: a highly coordinated system disrupted in the tumour tissues
Identifieur interne : 002065 ( Istex/Checkpoint ); précédent : 002064; suivant : 002066The glutathione-related detoxification pathway in the human breast: a highly coordinated system disrupted in the tumour tissues
Auteurs : Magali Perquin [France] ; Thierry Oster [France] ; Armand Maul [France] ; Nicolas Froment [France] ; Michel Untereiner [Luxembourg (pays)] ; Denyse Bagrel [France]Source :
- Cancer Letters [ 0304-3835 ] ; 2000.
Descripteurs français
- Wicri :
- topic : Règlement.
English descriptors
- KwdEn :
- Teeft :
- Assay, Breast cancer, Breast tumour, Breast tumours, Cancer cells, Cancer inst, Cancer letters, Cancer tissues, Class glutathione, Drug resistance, Elsevier science ireland, Enzyme activities, Expression levels, Glutathione, Glutathione contents, Glutathione pathway, Glutathione peroxidase, Glutathione peroxidases, Glutathione reductase, Glutathione system, Gpx1, Gssg, Gssg content, Gssr, Gssr activities, Gssr activity, Higher ratio, Human lung cancer tissues, Human tissues, Isoenzymes, Mammary cells, Median value, Other components, Pathway, Peritumoral, Peritumoral breast tissue, Peritumoral tissue, Peritumoral tissues, Peroxidase, Perquin, Possible relationships, Potassium phosphate buffer, Present study, Rank correlation sample size, Rank test, Redox, Redox status, Reductase, Reductase activities, Sample preparation, Sample size, Service pathologique, Statistical analyses, Statistical relationships, Tgpx, Tgsh, Tgst, Tumoral, Tumoral tissue, Tumoral tissues, Tumour.
Abstract
Abstract: Glutathione and the associated enzymes, glutathione S-transferases, peroxidases, and reductase, have been implicated in cancer chemoresistance. This pathway was investigated in paired cancerous and peritumoral breast samples from 41 women. The tumours exhibited a higher redox status as deduced from increased transferase, peroxidase, and reductase activities and from higher total and reduced glutathione contents. Several components were strongly correlated in peritumoral tissues, suggesting a highly co-ordinated glutathione pathway that appeared disrupted in breast tumours with only a few correlations left. Therefore, resistance could spontaneously result from deregulated variations in the glutathione pathway, which might be relevant to the malignant disease progression.
Url:
DOI: 10.1016/S0304-3835(00)00481-X
Affiliations:
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ISTEX:9DCA06E2A566461DEA9BCE58E523BDF2B090522ALe document en format XML
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