Identification and characterisation of a novel immune-type receptor (NITR) gene cluster in the European sea bass, Dicentrarchus labrax, reveals recurrent gene expansion and diversification by positive selection
Identifieur interne : 002914 ( Hal/Corpus ); précédent : 002913; suivant : 002915Identification and characterisation of a novel immune-type receptor (NITR) gene cluster in the European sea bass, Dicentrarchus labrax, reveals recurrent gene expansion and diversification by positive selection
Auteurs : Serena Ferraresso ; Heiner Kuhl ; Massimo Milan ; David Ritchie ; Christopher Secombes ; Richard Reinhardt ; Lucao BargelloniSource :
- Immunogenetics [ 0093-7711 ] ; 2009-10-22.
Abstract
In the last decade, a new gene family encoding non-rearranging receptors, called novel immune-type receptors (NITRs), has been discovered in teleost fish. NITRs belong to the immunoglobulin superfamily and represent an extraordinarily divergent and rapidly evolving gene complex. Genomic analysis of a region spanning 270 kb led to the discovery of a NITR gene cluster in the European sea bass (Dicentrarchus labrax). In total, 27 NITR genes and three putative pseudogenes, organised in a tandemly arrayed cluster, were identified. Sea bass NITR genes maintain the three major genomic organisations that appear to be essentially conserved among fish species along with new features presumably involving processes of intron loss, exon deletion and acquisition of new exons. Comparative and evolutionary analyses suggest that these receptors have evolved following a "birth-and-death" model of gene evolution in which duplication events together with lineage-specific gain and loss of individual members contributed to the rapid diversification of individual gene families. In this study, we demonstrate that species-specific gene expansions provide the raw material for diversifying, positive Darwinian selection favouring the evolution of a highly diverse array of molecules.
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DOI: 10.1007/s00251-009-0398-3
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Hal:inria-00434259Le document en format XML
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Reinhardt</name></author><author><name sortKey="Bargelloni, Lucao" sort="Bargelloni, Lucao" uniqKey="Bargelloni L" first="Lucao" last="Bargelloni">Lucao Bargelloni</name></author></analytic><idno type="DOI">10.1007/s00251-009-0398-3</idno><series><title level="j">Immunogenetics</title><idno type="ISSN">0093-7711</idno><imprint><date type="datePub">2009-10-22</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the last decade, a new gene family encoding non-rearranging receptors, called novel immune-type receptors (NITRs), has been discovered in teleost fish. NITRs belong to the immunoglobulin superfamily and represent an extraordinarily divergent and rapidly evolving gene complex. Genomic analysis of a region spanning 270 kb led to the discovery of a NITR gene cluster in the European sea bass (Dicentrarchus labrax). In total, 27 NITR genes and three putative pseudogenes, organised in a tandemly arrayed cluster, were identified. Sea bass NITR genes maintain the three major genomic organisations that appear to be essentially conserved among fish species along with new features presumably involving processes of intron loss, exon deletion and acquisition of new exons. Comparative and evolutionary analyses suggest that these receptors have evolved following a "birth-and-death" model of gene evolution in which duplication events together with lineage-specific gain and loss of individual members contributed to the rapid diversification of individual gene families. In this study, we demonstrate that species-specific gene expansions provide the raw material for diversifying, positive Darwinian selection favouring the evolution of a highly diverse array of molecules.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Identification and characterisation of a novel immune-type receptor (NITR) gene cluster in the European sea bass, Dicentrarchus labrax, reveals recurrent gene expansion and diversification by positive selection</title><author role="crp"><persName><forename type="first">Serena</forename><surname>Ferraresso</surname></persName><email>serena.ferraresso@unipd.it</email><idno type="halauthor">448585</idno><orgName ref="#struct-366829"></orgName></author><author role="aut"><persName><forename type="first">Heiner</forename><surname>Kuhl</surname></persName><email></email><idno type="halauthor">448586</idno><orgName ref="#struct-366830"></orgName></author><author role="aut"><persName><forename type="first">Massimo</forename><surname>Milan</surname></persName><email></email><idno type="halauthor">448587</idno><orgName ref="#struct-366829"></orgName></author><author role="aut"><persName><forename type="first">David</forename><surname>Ritchie</surname></persName><email>Dave.Ritchie@loria.fr</email><idno type="idhal">david-ritchie</idno><idno type="halauthor">448588</idno><affiliation ref="#struct-2358"></affiliation></author><author role="aut"><persName><forename type="first">Christopher</forename><forename type="middle">J.</forename><surname>Secombes</surname></persName><email></email><idno type="halauthor">448589</idno><orgName ref="#struct-366831"></orgName></author><author role="aut"><persName><forename type="first">Richard</forename><surname>Reinhardt</surname></persName><email></email><idno type="halauthor">448590</idno><orgName ref="#struct-366830"></orgName></author><author role="aut"><persName><forename type="first">Lucao</forename><surname>Bargelloni</surname></persName><email></email><idno type="halauthor">448591</idno><orgName ref="#struct-366829"></orgName></author><editor role="depositor"><persName><forename>David</forename><surname>Ritchie</surname></persName><email>Dave.Ritchie@inria.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2009-11-21 13:56:39</date><date type="whenModified">2016-05-18 08:57:29</date><date type="whenReleased">2009-11-21 13:56:39</date><date type="whenProduced">2009-10-22</date></edition><respStmt><resp>contributor</resp><name key="145516"><persName><forename>David</forename><surname>Ritchie</surname></persName><email>Dave.Ritchie@inria.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inria-00434259</idno><idno type="halUri">https://hal.inria.fr/inria-00434259</idno><idno type="halBibtex">ferraresso:inria-00434259</idno><idno type="halRefHtml">Immunogenetics, Springer Verlag, 2009, 61 (11-12), pp.773-788. <10.1007/s00251-009-0398-3></idno><idno type="halRef">Immunogenetics, Springer Verlag, 2009, 61 (11-12), pp.773-788. <10.1007/s00251-009-0398-3></idno></publicationStmt><seriesStmt><idno type="stamp" n="CNRS">CNRS - 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NITRs belong to the immunoglobulin superfamily and represent an extraordinarily divergent and rapidly evolving gene complex. Genomic analysis of a region spanning 270 kb led to the discovery of a NITR gene cluster in the European sea bass (Dicentrarchus labrax). In total, 27 NITR genes and three putative pseudogenes, organised in a tandemly arrayed cluster, were identified. Sea bass NITR genes maintain the three major genomic organisations that appear to be essentially conserved among fish species along with new features presumably involving processes of intron loss, exon deletion and acquisition of new exons. Comparative and evolutionary analyses suggest that these receptors have evolved following a "birth-and-death" model of gene evolution in which duplication events together with lineage-specific gain and loss of individual members contributed to the rapid diversification of individual gene families. In this study, we demonstrate that species-specific gene expansions provide the raw material for diversifying, positive Darwinian selection favouring the evolution of a highly diverse array of molecules.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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