Using ontology-based annotation to profile disease research
Identifieur interne : 000134 ( Ncbi/Merge ); précédent : 000133; suivant : 000135Using ontology-based annotation to profile disease research
Auteurs : Yi Liu [États-Unis] ; Adrien Coulet [États-Unis, France] ; Paea Lependu [États-Unis] ; Nigam H. Shah [États-Unis]Source :
- Journal of the American Medical Informatics Association : JAMIA [ 1067-5027 ] ; 2012.
Abstract
Profiling the allocation and trend of research activity is of interest to funding agencies, administrators, and researchers. However, the lack of a common classification system hinders the comprehensive and systematic profiling of research activities. This study introduces ontology-based annotation as a method to overcome this difficulty. Analyzing over a decade of funding data and publication data, the trends of disease research are profiled across topics, across institutions, and over time.
This study introduces and explores the notions of research sponsorship and allocation and shows that leaders of research activity can be identified within specific disease areas of interest, such as those with high mortality or high sponsorship. The funding profiles of disease topics readily cluster themselves in agreement with the ontology hierarchy and closely mirror the funding agency priorities. Finally, four temporal trends are identified among research topics.
This work utilizes disease ontology (DO)-based annotation to profile effectively the landscape of biomedical research activity. By using DO in this manner a use-case driven mechanism is also proposed to evaluate the utility of classification hierarchies.
Url:
DOI: 10.1136/amiajnl-2011-000631
PubMed: 22494789
PubMed Central: 3392849
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PMC:3392849Le document en format XML
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<p>Profiling the allocation and trend of research activity is of interest to funding agencies, administrators, and researchers. However, the lack of a common classification system hinders the comprehensive and systematic profiling of research activities. This study introduces ontology-based annotation as a method to overcome this difficulty. Analyzing over a decade of funding data and publication data, the trends of disease research are profiled across topics, across institutions, and over time.</p>
</sec>
<sec><title>Results</title>
<p>This study introduces and explores the notions of research sponsorship and allocation and shows that leaders of research activity can be identified within specific disease areas of interest, such as those with high mortality or high sponsorship. The funding profiles of disease topics readily cluster themselves in agreement with the ontology hierarchy and closely mirror the funding agency priorities. Finally, four temporal trends are identified among research topics.</p>
</sec>
<sec><title>Conclusions</title>
<p>This work utilizes disease ontology (DO)-based annotation to profile effectively the landscape of biomedical research activity. By using DO in this manner a use-case driven mechanism is also proposed to evaluate the utility of classification hierarchies.</p>
</sec>
</div>
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Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA</aff>
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LORIA–INRIA Nancy, Vandoeuvre-lès-Nancy Cedex, France</aff>
<author-notes><corresp><bold>Correspondence to</bold>
Yi Liu, Stanford University, Stanford Center for Biomedical Informatics, 1265 Welch Road, Medical School Office Building, Room X215 Mail Code 5479, Stanford, CA 94305, USA; <email>liuyipei@stanford.edu</email>
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<abstract><sec><title>Background</title>
<p>Profiling the allocation and trend of research activity is of interest to funding agencies, administrators, and researchers. However, the lack of a common classification system hinders the comprehensive and systematic profiling of research activities. This study introduces ontology-based annotation as a method to overcome this difficulty. Analyzing over a decade of funding data and publication data, the trends of disease research are profiled across topics, across institutions, and over time.</p>
</sec>
<sec><title>Results</title>
<p>This study introduces and explores the notions of research sponsorship and allocation and shows that leaders of research activity can be identified within specific disease areas of interest, such as those with high mortality or high sponsorship. The funding profiles of disease topics readily cluster themselves in agreement with the ontology hierarchy and closely mirror the funding agency priorities. Finally, four temporal trends are identified among research topics.</p>
</sec>
<sec><title>Conclusions</title>
<p>This work utilizes disease ontology (DO)-based annotation to profile effectively the landscape of biomedical research activity. By using DO in this manner a use-case driven mechanism is also proposed to evaluate the utility of classification hierarchies.</p>
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