Multiscale modeling of alternative splicing regulation
Identifieur interne : 007A19 ( Main/Merge ); précédent : 007A18; suivant : 007A20Multiscale modeling of alternative splicing regulation
Auteurs : Damien Eveillard ; Delphine Ropers ; Hidde De Jong ; Christiane Branlant ; Alexander BockmayrSource :
English descriptors
Abstract
Alternative splicing is a key process in post-transcriptional regulation, by which several kinds of mature RNA can be obtained from the same premessenger RNA. Using a constraint programming approach, we model the alternative splicing regulation at different scales (single site vs.\ multiple sites), thus exploiting different types of available experimental data.
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<author><name sortKey="Ropers, Delphine" sort="Ropers, Delphine" uniqKey="Ropers D" first="Delphine" last="Ropers">Delphine Ropers</name>
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<author><name sortKey="De Jong, Hidde" sort="De Jong, Hidde" uniqKey="De Jong H" first="Hidde" last="De Jong">Hidde De Jong</name>
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<author><name sortKey="Branlant, Christiane" sort="Branlant, Christiane" uniqKey="Branlant C" first="Christiane" last="Branlant">Christiane Branlant</name>
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<author><name sortKey="Bockmayr, Alexander" sort="Bockmayr, Alexander" uniqKey="Bockmayr A" first="Alexander" last="Bockmayr">Alexander Bockmayr</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>alternative splicing</term>
<term>bioinformatics</term>
<term>constraint programming</term>
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<front><div type="abstract" xml:lang="en" wicri:score="1047">Alternative splicing is a key process in post-transcriptional regulation, by which several kinds of mature RNA can be obtained from the same premessenger RNA. Using a constraint programming approach, we model the alternative splicing regulation at different scales (single site vs.\ multiple sites), thus exploiting different types of available experimental data.</div>
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