Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related Loci
Identifieur interne : 002A50 ( Hal/Corpus ); précédent : 002A49; suivant : 002A51Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related Loci
Auteurs : Claude Chelala ; Marie-Dominique Devignes ; Sandrine Imbeaud ; Rima Zoorob ; David Cox ; Charles Auffray ; Emmanuel Curis ; Simone BenazethSource :
- Journal of Biological Systems [ 0218-3390 ] ; 2002.
Abstract
The relationships between genetic or radiation hybrid (RH) and sequence maps of chromosome 22 have been reconsidered based on the sequence map. Integrated maps have been constructed by retaining only common markers between genetic or RH maps and the sequence map. Local inversions of markers have been detected. Ratios between either genetic or RH distances and sequence-based distances have been calculated for each map interval. Hot zones for recombination or radiation breakage have been delineated by merging together intervals displaying high distance ratios and located close to each other for sequence-constrained RH maps, and for female and male genetic maps. A statistically significant positive correlation was found between the distribution of disease-related genes and the hot zones for recombination or radiation breakage on both female genetic and Stanford-G3 RH maps. This observation indicates that investigation of chromosomal regions displaying inconsistencies between RH or genetic linkage and sequence-based maps can accelerate the initial phase of identification of disease-associated genes.
Url:
DOI: 10.1142/S0218339002000743
Links to Exploration step
Hal:inria-00000241Le document en format XML
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type="datePub">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The relationships between genetic or radiation hybrid (RH) and sequence maps of chromosome 22 have been reconsidered based on the sequence map. Integrated maps have been constructed by retaining only common markers between genetic or RH maps and the sequence map. Local inversions of markers have been detected. Ratios between either genetic or RH distances and sequence-based distances have been calculated for each map interval. Hot zones for recombination or radiation breakage have been delineated by merging together intervals displaying high distance ratios and located close to each other for sequence-constrained RH maps, and for female and male genetic maps. A statistically significant positive correlation was found between the distribution of disease-related genes and the hot zones for recombination or radiation breakage on both female genetic and Stanford-G3 RH maps. This observation indicates that investigation of chromosomal regions displaying inconsistencies between RH or genetic linkage and sequence-based maps can accelerate the initial phase of identification of disease-associated genes.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related Loci</title><author role="aut"><persName><forename type="first">Claude</forename><surname>Chelala</surname></persName><email></email><idno type="halauthor">59047</idno><affiliation ref="#struct-7107"></affiliation></author><author role="aut"><persName><forename type="first">Marie-Dominique</forename><surname>Devignes</surname></persName><email>devignes@loria.fr</email><idno type="halauthor">52674</idno><affiliation ref="#struct-2351"></affiliation></author><author role="aut"><persName><forename type="first">Sandrine</forename><surname>Imbeaud</surname></persName><email></email><idno type="halauthor">59048</idno><affiliation ref="#struct-7107"></affiliation></author><author role="aut"><persName><forename type="first">Rima</forename><surname>Zoorob</surname></persName><email></email><idno type="halauthor">59049</idno><affiliation ref="#struct-7107"></affiliation></author><author role="aut"><persName><forename type="first">David</forename><surname>Cox</surname></persName><email></email><idno type="halauthor">59050</idno></author><author role="aut"><persName><forename type="first">Charles</forename><surname>Auffray</surname></persName><email></email><idno type="halauthor">59042</idno><affiliation ref="#struct-7107"></affiliation></author><author role="aut"><persName><forename type="first">Emmanuel</forename><surname>Curis</surname></persName><email></email><idno type="halauthor">59051</idno><affiliation ref="#struct-7108"></affiliation></author><author role="aut"><persName><forename type="first">Simone</forename><surname>Benazeth</surname></persName><email></email><idno type="halauthor">59052</idno><affiliation ref="#struct-7108"></affiliation></author><editor role="depositor"><persName><forename>Marie-Dominique</forename><surname>Devignes</surname></persName><email>devignes@loria.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2005-09-16 12:40:15</date><date type="whenModified">2016-05-19 01:09:15</date><date type="whenReleased">2005-09-16 12:40:15</date><date type="whenProduced">2002</date></edition><respStmt><resp>contributor</resp><name key="103147"><persName><forename>Marie-Dominique</forename><surname>Devignes</surname></persName><email>devignes@loria.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inria-00000241</idno><idno type="halUri">https://hal.inria.fr/inria-00000241</idno><idno type="halBibtex">chelala:inria-00000241</idno><idno type="halRefHtml">Journal of Biological Systems, World Scientific Publishing, 2002, 10, pp.303-317. <10.1142/S0218339002000743></idno><idno type="halRef">Journal of Biological Systems, World Scientific Publishing, 2002, 10, pp.303-317. <10.1142/S0218339002000743></idno></publicationStmt><seriesStmt><idno type="stamp" n="INRIA">INRIA - Institut National de Recherche en Informatique et en Automatique</idno><idno type="stamp" n="UNIV-PARIS5">Université Paris Descartes (Paris 5)</idno><idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno><idno type="stamp" n="INPL">Institut National Polytechnique de Lorraine</idno><idno type="stamp" n="LORIA2">Publications du LORIA</idno><idno type="stamp" n="LORIA">LORIA - Laboratoire Lorrain de Recherche en Informatique et ses Applications</idno><idno type="stamp" n="INRIA-NANCY-GRAND-EST">INRIA Nancy - Grand Est</idno><idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno><idno type="stamp" n="INRIA-LORRAINE">INRIA Nancy - Grand Est</idno><idno type="stamp" n="LABO-LORIA-SET" p="LORIA">LABO-LORIA-SET</idno></seriesStmt><notesStmt><note type="commentary">http://www.worldscinet.com</note><note type="audience" n="1">Not set</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related Loci</title><author role="aut"><persName><forename type="first">Claude</forename><surname>Chelala</surname></persName><idno type="halAuthorId">59047</idno><affiliation ref="#struct-7107"></affiliation></author><author role="aut"><persName><forename type="first">Marie-Dominique</forename><surname>Devignes</surname></persName><email>devignes@loria.fr</email><idno type="halAuthorId">52674</idno><affiliation ref="#struct-2351"></affiliation></author><author role="aut"><persName><forename type="first">Sandrine</forename><surname>Imbeaud</surname></persName><idno type="halAuthorId">59048</idno><affiliation ref="#struct-7107"></affiliation></author><author role="aut"><persName><forename type="first">Rima</forename><surname>Zoorob</surname></persName><idno type="halAuthorId">59049</idno><affiliation ref="#struct-7107"></affiliation></author><author role="aut"><persName><forename type="first">David</forename><surname>Cox</surname></persName><idno type="halAuthorId">59050</idno></author><author role="aut"><persName><forename type="first">Charles</forename><surname>Auffray</surname></persName><idno type="halAuthorId">59042</idno><affiliation ref="#struct-7107"></affiliation></author><author role="aut"><persName><forename type="first">Emmanuel</forename><surname>Curis</surname></persName><idno type="halAuthorId">59051</idno><affiliation ref="#struct-7108"></affiliation></author><author role="aut"><persName><forename type="first">Simone</forename><surname>Benazeth</surname></persName><idno type="halAuthorId">59052</idno><affiliation ref="#struct-7108"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">15135</idno><idno type="issn">0218-3390</idno><idno type="eissn">0218-3390</idno><title level="j">Journal of Biological Systems</title><imprint><publisher>World Scientific Publishing</publisher><biblScope unit="volume">10</biblScope><biblScope unit="pp">303-317</biblScope><date type="datePub">2002</date></imprint></monogr><idno type="doi">10.1142/S0218339002000743</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="halDomain" n="sdv.bbm.gtp">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">The relationships between genetic or radiation hybrid (RH) and sequence maps of chromosome 22 have been reconsidered based on the sequence map. Integrated maps have been constructed by retaining only common markers between genetic or RH maps and the sequence map. Local inversions of markers have been detected. Ratios between either genetic or RH distances and sequence-based distances have been calculated for each map interval. Hot zones for recombination or radiation breakage have been delineated by merging together intervals displaying high distance ratios and located close to each other for sequence-constrained RH maps, and for female and male genetic maps. A statistically significant positive correlation was found between the distribution of disease-related genes and the hot zones for recombination or radiation breakage on both female genetic and Stanford-G3 RH maps. This observation indicates that investigation of chromosomal regions displaying inconsistencies between RH or genetic linkage and sequence-based maps can accelerate the initial phase of identification of disease-associated genes.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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