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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Physical properties of VNTR data, and their impact on a test of allelic independence.</title><author><name sortKey="Devlin, B" sort="Devlin, B" uniqKey="Devlin B" first="B" last="Devlin">B. Devlin</name></author><author><name sortKey="Risch, N" sort="Risch, N" uniqKey="Risch N" first="N" last="Risch">N. Risch</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">8328451</idno><idno type="pmc">1682343</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682343</idno><idno type="RBID">PMC:1682343</idno><date when="1993">1993</date><idno type="wicri:Area/Pmc/Corpus">000041</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000041</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Physical properties of VNTR data, and their impact on a test of allelic independence.</title><author><name sortKey="Devlin, B" sort="Devlin, B" uniqKey="Devlin B" first="B" last="Devlin">B. Devlin</name></author><author><name sortKey="Risch, N" sort="Risch, N" uniqKey="Risch N" first="N" last="Risch">N. Risch</name></author></analytic><series><title level="j">American Journal of Human Genetics</title><idno type="ISSN">0002-9297</idno><idno type="eISSN">1537-6605</idno><imprint><date when="1993">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this article we describe the physical properties of VNTR data, as well as their effects on the two-dimensional distribution of fragment pairs. Tests of independence of alleles at a locus may confound those physical properties with allele independence. A recently proposed test by Geisser and Johnson is an example. We show that alleles can be strictly independent, yet the proposed test suggests large violations of allele independence because it is sensitive to well-known electrophoretic phenomena.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Hum Genet</journal-id><journal-title>American Journal of Human Genetics</journal-title><issn pub-type="ppub">0002-9297</issn><issn pub-type="epub">1537-6605</issn></journal-meta><article-meta><article-id pub-id-type="pmid">8328451</article-id><article-id pub-id-type="pmc">1682343</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Physical properties of VNTR data, and their impact on a test of allelic independence.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Devlin</surname><given-names>B</given-names></name></contrib><contrib contrib-type="author"><name><surname>Risch</surname><given-names>N</given-names></name></contrib></contrib-group><aff>Department of Epidemiology and Public Health, Yale University, New Haven, CT 06510.</aff><pub-date pub-type="ppub"><month>8</month><year>1993</year></pub-date><volume>53</volume><issue>2</issue><fpage>324</fpage><lpage>329</lpage><abstract><p>In this article we describe the physical properties of VNTR data, as well as their effects on the two-dimensional distribution of fragment pairs. Tests of independence of alleles at a locus may confound those physical properties with allele independence. A recently proposed test by Geisser and Johnson is an example. We show that alleles can be strictly independent, yet the proposed test suggests large violations of allele independence because it is sensitive to well-known electrophoretic phenomena.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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